Otitis

Remantadine loading dose for adults. Remantadine tablets - instructions for use

Remantadine is a well-known medical drug, which the world first saw in 1965. Since that time, it has been in wide demand in the treatment of colds. This is due to the fact that with the help of the active components of the drug it is possible to defeat the causative agent of the disease and speed up the healing process.

Benefit and action

The positive effect of taking Remantadine is due to the fact that it covers the cells of its host and thereby prevents the virus from penetrating inside. This way you can slow down the spread infectious process. The action of Remantadine is aimed at releasing the viral DNA of the cell, while the virus itself will be inside. Then the development of the disease stops.

In the photo - rimantadine for the treatment of colds

The drug in question is effective for colds, as it will help provide the following effects:

immunomodulatory;
antitoxic;
stimulates interferon synthesis;
increases cell activity.

The structure of the drug is cyclic, due to which its active components are able to move throughout the body for a long time. Thanks to this property of the medicine, it can be used not only for the treatment, but also for the prevention of colds.

With the help of Remantadine you can even early stage influenza to prevent its development. But it is important to do this provided that no more than 2 days have passed since the beginning of development. The drug is effective for the prevention of acute respiratory viral infections and influenza during an epidemic.

Taking medication with high blood pressure and atherosclerosis should be done with caution. It’s better to find out everything from your doctor before doing this. Otherwise, this can lead to an exacerbation of the disease and cause a hemorrhagic stroke.

It is extremely important for people who suffer from epileptic seizures and diabetes to obtain a doctor’s permission to take Remantadine.

On video how to take remantadine for a cold:

The drug also has the following contraindications for appointment:

Hypersensitivity to a certain component.
Pathologies of the kidneys and liver.
Active functioning of the thyroid gland.
Pregnancy.
Age up to seven years.
Epileptic seizures
Cerebral sclerosis.

After the penetration of the active components into the body, after 5 hours they begin to fight pathogenic microorganisms. And a day after the first use, the patient feels much better, as he manages to cope with the following symptoms:

the temperature drops;
the inflammatory process in the ENT organs goes away;
doesn't bother headache;
relieved nasal breathing;
swelling of the mucous membranes of the nasopharynx decreases;
muscle pain and weakness goes away.

Here's how to treat it folk remedies for colds, and which home remedies are the most effective, this article will help you understand.

How to use Acetylsalicylic acid and Paracetamol simultaneously for colds is described in great detail here in the article.

What causes of a cough without a cold can be identified independently, and which of them can be identified independently, are described in this article: http://prolor.ru/g/bolezni-g/kashel/prichiny-bez-prostudy-u-vzroslogo.html

This article will help you understand what pills to take for a cold without fever, and how to choose the right medications.

How to take

What is the dosage regimen? It is extremely important to visit a doctor before taking the drug. Only he will be able to determine the duration of therapy and the required dosage. If you are taking the drug to older people, then you need to do this with increased attention, since the patient’s condition can worsen at any time. And the reason for this is the rapid development hypertension, severe atherosclerosis and Parkinson's disease.

IN medical practice frequent cases have been recorded when a violation was observed when taking Remantadine cerebral circulation. This pathology is more typical for people over 50 years of age.

On video instructions on the use of tablets:

When treating a cold, the drug must be taken in a certain dosage, which is determined taking into account the patient’s age:

for patients aged 7-10 years – no more than 1 pill twice a day;
for patients aged 11-15 years – 1 pill three times a day;
for adults – 2 tablets 2-3 times a day

Does it help?

Remantadine is one of the most effective remedies for treating colds. Its effectiveness is due to the fact that it is able to stop the reproduction of viruses that are not yet at the initial stage of development of pathology. The active components of the drug are able to penetrate into the cell membrane of the pathogen, resulting in its death.

In addition, with the help of an antiviral agent it is possible to eliminate arboviruses. And, as is known, they lead to the development of encephalitis.

You may also be interested in learning about what antibiotic to give your child for a cold, and how to choose it.

How treatment occurs at the first signs of a cold in adults, and what home remedies should be used, is described in great detail in this article.

But how to take Paracetamol for a cold, and how effective this remedy is, is described in great detail in this article.

It will also be interesting to learn about how to use Kagocel cold tablets.

Is it possible to use Viferon suppositories for pregnant women with a cold, and what reviews exist on this matter, this article will help you understand.

Reviews

Maria, 35 years old: “Not long ago my daughter had a cold. I took a vacation and began to treat her, while I was with her all the time. After that, my husband began to get sick. But I didn’t, because I took Remantadine in a timely manner, 1 tablet per day for preventive purposes. I would like to note that the drug has repeatedly helped me out throughout the autumn-winter period. And I was destined to get sick only once. At the same time, my work involves constant contact with sick children, since I am a teacher in kindergarten. I did not find any side effects from taking the drug; the manufacturer indicates this information in the instructions.”
Angelina, 45 years old: “Last year my husband had the flu. We called a doctor to the house, she prescribed us a whole list of medications, among which I discovered Remantadine. I thought it was some kind of expensive medicine, but to my surprise the price was quite reasonable. After the first dose, my husband began to notice how his condition improved. Thus, the flu was mild, without complications. My opinion is that it was medication and drinking plenty of fluids that helped cope with this serious illness. I cannot help but note that Remantadine is well tolerated by the body. You can buy it without a prescription at the pharmacy.”
Igor, 54 years old: “I don’t really like being sick for the reason that I have to pay a decent amount of money to buy medicine. But that year I fell ill with ARVI. The disease did not proceed as usual, so I decided to call doctors at home. After their arrival, the wife went to the pharmacy and bought Remantadine and several other medications according to the treatment regimen. Imagine her surprise that the drug in question turned out to be not so expensive. But it can’t be taken away from its effectiveness. When I started taking the medicine, I noticed how the sore throat left me the very next day after using the pills. But on day 3, all the symptoms of the pathology disappeared without a trace.”

Remantadine is one of the effective antiviral drugs that can be used to successfully treat colds and flu. In addition, the medicine can be used for preventive purposes. Its composition is designed so that children can take it. Side effects and complications occur extremely rarely, which indicates high efficiency Remantadine.

Colds can come on suddenly. It is often accompanied by an increase in temperature, weakness, sore throat and aches. Often in such cases, Remantadine is taken for a cold. What kind of drug is this and how effective is it in treatment?

Remantadine belongs to the group of antiviral drugs. It is considered to be a derivative of adamantane. The main mechanism of action lies in the inhibition of the early stage of specific reproduction after viral agents enter the cell membrane.

It is often prescribed for:

herpes infection of the first and second types;
tick-borne encephalitis;
influenza infection;
colds.

This medication is not prescribed for acute respiratory diseases, because they appear in the background bacterial infection. But Remantadine does not belong to the group of antibacterial agents.

Remantadine helps with colds positive influence on the body. This process is associated with the fact that main component in the form of rimantadine prevents the viral agent from penetrating into cells. Thus, there is a slowdown inflammatory process. The effect of the drug is directed towards the release of viral DNA from the cell.

Remantadine tablets for colds are considered effective because they allow you to achieve:

immunostimulating effect;
antitoxic effect;
increasing cell activity;
stimulating the synthesis of interferons.

The structure of the drug is cyclic. Thanks to this phenomenon active ingredient Maybe long time be in the body and move freely around it. Remantadine is often used not only for colds, but also for preventive purposes.

At the first signs of a cold, it is possible to completely prevent the development of the inflammatory process and symptoms. But these actions must be performed no later than two days after the onset of symptoms.

After taking the first tablet, five hours later, the body begins to actively fight harmful microbes. After about a day, the patient feels much better, as he manages to cope with unpleasant symptoms. There is a significant decrease in temperature indicators, it goes away pathological process in the ENT organs, pain in the head ceases to bother you, nasal breathing becomes easier and swelling of tissue structures decreases.

How to take Remantadine for respiratory infection? There is a certain scheme that must be strictly followed by adults.

On the first day, take two tablets up to three times a day.

On the second and third days you need to take two tablets up to two times a day.

On the fourth and fifth days, therapy consists of taking two tablets once a day.

The medicine can be given to children over seven years of age. How to take the medicine in this case? For children, the drug is given two tablets twice a day. Duration therapeutic therapy is five days.

You can take the medicine as a preventive measure. Then the dosage is fifty milligrams up to once a day. The duration of this course ranges from ten to fifteen days.

It is recommended to take rimantadine if you are bitten by a tick. This will have therapeutic effect with encephalitis. The medication should be taken within three days. This process will help avoid the development of serious complications.

Remantadine is usually prescribed to adult patients. But in pediatrics it is also used in children over seven years of age. Elderly people are not advised to use the drug, as it can lead to poor blood circulation in the brain.

Also contraindicated for use are:

various liver diseases in acute period;
diseases of the kidney structures;
development of thyrotoxicosis;
gestation period;
increased sensitivity to the main ingredient.

Remantadine can be taken during breastfeeding. But during treatment it is worth giving up lactation.

The medication is taken with extreme caution for arterial hypertension, epileptic disorder, and atherosclerosis of blood vessels in the brain.

When using rimantadine, exacerbation of chronic diseases is possible. If the patient has group B influenza, the medicine has an antitoxic effect.

Taking the product simultaneously with alcoholic beverages is strictly prohibited. Otherwise, this process will negatively affect the liver tissue.

Remantadine should not be taken simultaneously with:

antiepileptic drugs, as their effectiveness decreases;
adsorbents, since astringent and enveloping properties reduce the absorption of rimantadine;
agents that lead to oxidation of urine. Remantadine simply does not stay in the kidneys and is released unchanged.

When using the medication, you may experience side effects in the form:

pain in the epigastric area;
development of flatulence;
raising the level of bilirubin in the blood;
dryness in oral cavity;
the occurrence of anorexia;
nausea and vomiting;
pain in the head;
insomnia;
nervousness and irritability;
dizziness and difficulty concentrating;
drowsiness and increased anxiety;
increased excitability;
fatigue;
development of allergic reactions in the form of swelling and rashes on the skin.

If such symptoms occur, the drug should be discontinued. In most cases, the drug is well tolerated.

The drug has no structural analogues, but other antiviral agents exist. Since Remantadine has a limitation in the form childhood up to seven years of age, then children are advised to give more than safe means in the form:

Anaferona. Available in tablet form;
Viferona. Sold as candles;
Cytovir-3. Sold in syrup form.

The duration of treatment is five days.

Older children, adolescents and adults are advised to take the following instead of Remantadine:

Has a good effect modern drug in the form of Polyoxidonium. It helps prevent the development of colds and herpes infections various types, influenza infection.

There are also homeopathic remedies. They are approved for use in children of any age and the elderly, as they have a minimum of restrictions and do not cause side effects.

This may include:

Treatment of colds should not be limited only to taking antiviral drugs. You also need:

take antipyretics in the form of Paracetamol, Ibuprofen, Panadol, Nurofen;
irrigate the throat with a solution of Lugol, Chlorophyllipt, Miramistin;
rinse the oropharyngeal area with saline and soda solution;
use large number liquids up to two liters per day;
take a decoction of rosehip and chamomile to provide an anti-inflammatory and immunostimulating effect.

Remantadine is good and effective means, but it has a number of limitations and can cause side effects.

International nonproprietary name

Rimantadine

Pharmgroup

Antiviral agents

Compound

Active substance: rimantadine hydrochloride - 50 mg.

Excipients: lactose monohydrate (milk sugar) - 60 mg, potato starch - 37 mg, talc - 1.5 mg, calcium stearate monohydrate - 1.5 mg.

Pharmacological action

Rimantadine is active against various strains of influenza A virus.

Being a weak base, rimantadine acts by increasing the pH of endosomes, which are membrane-bound vacuoles that surround viral particles after they enter the cell. Preventing acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thereby preventing transmission of the viral genetic material into the cytoplasm of the cell. Rimantadine also inhibits the release of viral particles from the cell, that is, it interrupts the transcription of the viral genome.

Pharmacokinetics

After oral administration, rimantadine is almost completely absorbed from the intestine. Absorption is slow. Communication with plasma proteins is about 40%. Volume of distribution: adults - 17 - 25 l/kg, children - 289 l. The concentration in nasal secretions is 50% higher than in plasma. Maximum concentration active substance in blood plasma at a dose of 100 mg once a day - 181 ng/ml, at 100 mg 2 times a day - 416 ng/ml. Metabolized in the liver. Half-life - 24 - 36 hours; 75 - 85% of the dose taken is excreted by the kidneys mainly in the form of metabolites, 15% unchanged.

For chronic renal failure the half-life increases by 2 times. May accumulate in toxic concentrations in persons with renal impairment and in the elderly unless the dose is adjusted proportionately to the decrease in creatinine clearance.

Indications for use

Treatment and prevention of influenza in adults and children over 7 years of age.

Contraindications

acute liver diseases;
acute and chronic kidney diseases;
thyrotoxicosis;
hypersensitivity to rimantadine;
pregnancy and period breastfeeding;
children under 7 years old;
for lactose deficiency, lactose intolerance, glucose-galactose malabsorption (since the drug contains lactose).

Use during pregnancy and breastfeeding

Rimantadine is contraindicated during pregnancy and breastfeeding.

With caution

Arterial hypertension, cerebral atherosclerosis, liver failure, epilepsy, diseases gastrointestinal tract.

Special instructions

When using rimantadine, exacerbation of chronic concomitant diseases. Elderly patients with arterial hypertension have an increased risk of developing hemorrhagic stroke.

If there is a history of epilepsy and ongoing anticonvulsant therapy while using rimantadine, the risk of developing epileptic seizure. In such cases, rimantadine is used at a dose of 100 mg per day simultaneously with anticonvulsant therapy.

Prophylactic administration is effective during contacts with sick people, during the spread of infection in closed groups and at a high risk of developing the disease during an influenza epidemic.
Viruses resistant to the drug may emerge.

Impact on the ability to drive vehicles and operate machinery

During the treatment period it is necessary to refrain from driving vehicles and occupations with others potentially dangerous species activities that require increased concentration and speed of psychomotor reactions.

Directions for use and doses

Inside, after meals, with water.

Treatment for influenza should begin within 24 to 48 hours of the onset of symptoms.

Adults are prescribed 100 mg 3 times a day on the first day; on the second and third days, 100 mg 2 times a day; on the fourth and fifth days, 100 mg once a day. On the first day of the disease, it is possible to use the drug once at a dose of 300 mg.

Children aged 7 to 10 years are prescribed 50 mg 2 times a day; from 11 to 14 years - 50 mg 3 times a day.
Over 14 years of age - adult doses. Take within 5 days.

To prevent influenza, adults are prescribed 50 mg once daily for up to 30 days. Children over 7 years old - 50 mg once a day for 15 days.

Side effect

From the outside digestive system: dry mouth, nausea, vomiting, loss of appetite, epigastric pain, flatulence.

From the central side nervous system: headache, dizziness, insomnia, difficulty concentrating, drowsiness, anxiety, increased excitability, fatigue.

Other: hyperbilirubinemia, allergic reactions(skin rash, itching, urticaria).

Overdose

Symptoms: agitation, hallucinations, arrhythmia.

Treatment: gastric lavage, symptomatic therapy: measures to maintain vital important functions. Rimantadine is partially eliminated by hemodialysis.

Interaction with other drugs

Rimantadine reduces the effectiveness of antiepileptic drugs.
Paracetamol and ascorbic acid reduce the maximum concentration of rimantadine in blood plasma by 11%.

Cimetidine reduces the clearance of rimantadine by 18%.

Adsorbents, binders and enveloping agents reduce the absorption of rimantadine.

Urine alkalizing agents (acetazolamide, sodium bicarbonate and others) increase the effectiveness of rimantadine due to a decrease in its excretion by the kidneys.

Release form

Pills

Storage conditions

In a dry place at a temperature not exceeding 25 °C.

Best before date

Photo of the drug

Latin name: Remantadin

ATX code: J05AC02

Active ingredient: Rimantadine

Manufacturer: Olainfarm (Latvia), Rozfarm LLC (Russia), Irbitsky HFZ OJSC (Russia), OFP Obolenskoye FP CJSC (Russia), Tatkhimfarmpreparaty OJSC (Russia), Moscow endocrine plant(Russia)

Description is valid on: 09.10.17

Remantadine - antiviral agent, which has immunomodulatory and antitoxic effects. The drug reduces the risk of influenza and, if present, promotes rapid recovery. Remantadine is also used for prevention tick-borne encephalitis.

Active ingredient

Rimantadine.

Release form and composition

Indications for use

prevention of tick-borne encephalitis;
flu prevention;
early treatment of influenza.

Contraindications

spicy and chronic diseases kidney;
acute liver diseases;
thyrotoxicosis;
hypersensitivity to the active substance or auxiliary components of the drug;
children under seven years of age;
pregnancy and lactation (breastfeeding).

The drug is prescribed with extreme caution for diseases of the digestive system, renal failure, arterial hypertension, epilepsy and cerebral atherosclerosis.

Instructions for use of Remantadine (method and dosage)

Take after eating. Treatment should begin as soon as the first symptoms of influenza appear. The duration of therapy and dosage are determined by the doctor.

On the first day of influenza, adults and adolescents take the medicine 100 mg 3 times a day. On the second and third days of illness, take 100 mg of the drug 2 times a day, and on the fourth and fifth days - 100 mg of Remantadine once.

Children from 7 to 10 years old are prescribed 50 mg 2 times a day, from 11 to 14 years old - 3 times a day. Course - 5 days.
After the bite encephalitis tick- 100 mg 2 times a day for the next 72 hours.
As prophylactic- 50 mg 1 time per day for 10–15 days.

Side effects

The use of the drug may lead to the following adverse reactions:

from the central nervous system:
insomnia, dizziness, headache, neurological reactions, anxiety, drowsiness, fatigue, impaired concentration and increased excitability;
from the digestive system: epigastric pain (in the stomach area), nausea, vomiting, flatulence, loss of appetite and dry mouth;
other: allergic reactions (urticaria, itching, skin rash) and hyperbilirubinemia.

Overdose

In case of overdose, symptoms such as arrhythmia, hallucinations and agitation are observed. Treatment of overdose includes immediate gastric lavage and symptomatic therapy.

Analogues

Analogs by ATC code: Algirem, Orvirem, Rimantadine tablets, Rimantadine.

Do not decide to change the drug on your own; consult your doctor.

Pharmacological action

Remantadine is a chemotherapy drug with antiviral activity, which is a derivative of amantadine and midantan. This medicine used as an antiparkinsonian drug.

Remantadine is active against tick-borne encephalitis virus, as well as influenza A. The drug has an effect on human body antitoxic and immunomodulatory effects.
Since long-term circulation of the drug in the body is ensured by its polymer structure, the long half-life of Remantadine makes it possible to prescribe this drug not only for therapeutic purposes, but also for the prevention of influenza and encephalitis.
The use of the drug helps to increase the functionality of lymphocytes, the production of alpha and gamma interferons, as well as the suppression of specific viral reproduction at the initial stage. This medicine prevents viral particles from leaving cells.
Reduces the risk of getting the flu. Subject to availability of this disease the above medicine helps speedy recovery. The drug is most active in the first 18 hours feeling unwell. Initial stage influenza is the main indication for Remantadine.
The drug is adsorbed in the gastrointestinal tract 2-4 hours after oral administration. Active ingredient Rimantadine is metabolized in the liver. The half-life of the drug is 25-30 hours.

Special instructions

Use with caution in cases of arterial hypertension, epilepsy, and cerebral atherosclerosis.
Rimantadine can provoke exacerbation of chronic concomitant diseases. Elderly patients with arterial hypertension have an increased risk of developing hemorrhagic stroke. In patients with epilepsy on anticonvulsant therapy, the risk of an epileptic seizure increases with the use of rimantadine. In such cases, the dose is reduced to 100 mg/day.
For influenza caused by virus B, rimantadine reduces signs of intoxication.
The drug is effective in contact with patients during influenza epidemics. But the emergence of viruses resistant to rimantadine is possible.

During pregnancy and breastfeeding

The drug is contraindicated during pregnancy.

In childhood

The drug is contraindicated in children under 7 years of age.

In old age

In elderly people, the drug may accumulate in toxic concentrations if the drug dose is not adjusted in proportion to the decrease in creatinine clearance. Elderly people with arterial hypertension have an increased risk of developing hemorrhagic stroke while taking it.

For impaired renal function

The drug is contraindicated in acute and chronic kidney diseases.

For liver dysfunction

The drug is contraindicated in acute and chronic liver diseases.

Drug interactions

Rimantadine reduces the effectiveness of antiepileptic drugs.
Adsorbents. astringents and enveloping drugs reduce the absorption of rimantadine.
The effectiveness of the drug is reduced by drugs that acidify urine, and increased by drugs that alkalize urine.
Cimetidine reduces the clearance of rimantadine.

Remantadine is a drug belonging to the group of antiviral drugs. Rimantadine - official international name, Remantadine – registered trademark. Both names, according to information from the instructions, are synthetic derivatives of amantadine. Remantadine was invented in 1963 while studying amantadine derivatives. In 1969, a group of Soviet chemists achieved an improvement in the composition, which served widespread drug.
In 2007, the Formulary Committee of the Russian Academy of Medical Sciences described this medication as “outdated, with unproven effectiveness.” Studies conducted in the USA over the past 10 years prove the low effectiveness of Remantadine against existing strains of the influenza virus, since mutations of viruses have contributed to the emergence of resistance to this drug forms Nevertheless, Remantadine is quite actively used as part of preventive and antiviral therapy due to the spectrum of action and low cost of the drug.

Indications for use

Despite the proven low effectiveness of the drug against common strains of influenza A and B, it is used for preventive and therapeutic purposes by blocking the synthesis of proteins necessary for the synthesis of viral cells, and is also used in the treatment of suspected or infected encephalitis virus and as part of antiherpes therapy.

Remantadine: instructions for use

Instructions for use differ slightly for different names of the drug, mainly due to the increased amount of active substance in Rimantadine. Standard recommendations are based on a dose of 50 mg, which corresponds to 1 tablet of Remantadine. Before use, consultation with a specialist is recommended.
Reception is carried out regardless of food. Tablets and capsules must be swallowed whole, without opening, breaking, chewing, etc., and washed down sufficient quantity liquids. It is also important to maintain equal time intervals between taking doses of the drug during the day, which is caused by the slow absorption of the active substance into the systemic circulation and the low rate of metabolism and excretion from the body. If the equivalence of time intervals is violated, manifestations of side effects or symptoms of drug overdose.

Flu prevention

For prophylactic purposes, the drug is prescribed to patients over 10 years of age without contraindications. Prevention is carried out during the season of epidemics and pandemics if there is high risk infection, contact with sick people.
Dosage of the drug: 1 tablet (50 mg) once a day for 1 month. If missed, the dose is resumed without increasing the dosage, following the usual prophylaxis regimen.
At preventive measures in patients under 10 years of age, the dosage is calculated based on the child’s body weight. To maintain the exact age dosage in children from 1 to 7 years old, syrups Orvirem, Algirem, liquid forms rimantadine, developed for early childhood.
Taking any form of amantadine derivatives by children under 1 year of age is prohibited.

Flu treatment

Therapy is effective in the early stages of the disease with initial symptoms diseases. The effect of the drug on viral cells is manifested if no more than 18 hours have passed from the moment of the first signs of infection to administration. The dosage and frequency of taking the drug depends on the age of the patient.
Children from 7 to 10 years old take 1 tablet (50 mg) twice a day.
For children aged 11-14 years, the frequency of administration is 3 times a day, 1 tablet.
For children over 14 years of age and adults, a step-by-step treatment regimen is recommended:

on the 1st day of symptoms, 6 tablets (300 mg) once or divided into 2-3 doses, but not more than 300 mg in 24 hours;
Days 2 and 3 of illness: 200 mg (4 tablets) in two doses;
Days 4 and 5: 2 tablets once a day.

Course of treatment for different types– no longer than 5 days.
Early use of the drug at the onset of the disease reduces the severity of intoxication, reduces the period of fever by 1 day compared to taking a placebo, and helps the patient recover more quickly.

Tick-borne encephalitis

Remantadine is effective in prophylactic and therapeutic use against encephalitis viral etiology. To prevent tick-borne encephalitis when visiting an area with a high probability of infection, take 1 tablet twice a day for 15 days.
In case of a tick bite, the dose is increased to 100 mg twice a day, duration of administration is 3-5 days.

Contraindications for use according to the instructions for the drug

The instructions for the drug include contraindications for prevention and therapy. There are unconditional contraindications and conditional restrictions.
Unconditional contraindications for which Remantadine should not be taken include:

enzyme and metabolic disorders: lactase deficiency, galactosemia, disturbances in the absorption of glucose and galactose;
thyrotoxicosis;
renal, liver failure;
children under 7 years of age;
gestational period (pregnancy) due to the teratogenic effect identified in animal studies active drug for the embryo and fetus.

During lactation it is not recommended to take the drug, if necessary of this type antiviral therapy should be limited or discontinued by the child breast milk, produced during treatment of the mother.
Conditional contraindications that are taken into account when prescribing the drug and assessing the risks include:

allergic reactions;
increased individual sensitivity to the components of the drug;
heart rhythm disturbances;
diseases of the cardiovascular system;
diseases of the digestive system.

Side effects when taken

Remantadine is a drug with a low number of side effects that occur with low frequency. Unlike Amantadine, dysfunction of the gastrointestinal tract has practically not been identified by studies. However, the instructions for medicine notes possible side effects from courses of prevention and treatment with Remantadine. The following side effects may occur:

dizziness, episodes of impaired concentration, psychomotor activity;
mild, unexpressed headaches;
sleep disorders;
dryness of the oral mucosa, nausea, episodes of vomiting;
increased levels of bilirubin in the blood;
abdominal pain, flatulence.

Allergic reactions when they occur are limited in most cases skin, manifested by a rash like urticaria and itchy skin.
If side effects occur, it is necessary to consult a specialist regarding the advisability of continuing the course of therapy, changing the dosage or replacing the drug/active substance.
Due to the likelihood of dizziness as a side effect, driving a car, performing work that requires increased concentration, etc. is not recommended during preventive and therapeutic courses of taking the drug.

Remantadine: consequences of taking increased doses of the drug

Reception antiviral drug should be carried out in accordance with age and individual characteristics patient at the indicated dosages. Exceeding doses and frequency of administration does not lead to increased antiviral and antitoxic effects, but may cause negative consequences. Most often, dysfunctions of the gastrointestinal tract, episodes of impaired consciousness, and severe allergic reactions are observed.
There is no specific antidote to Remantadine. Therapy is carried out by gastric lavage, if necessary - observation in a hospital, prescribing symptomatic drugs.

Remantadine in combination with other medications

Like other drugs, Remantadine should not be combined with the simultaneous use of absorbents, agents with astringent effects that coat the gastric and intestinal mucosa due to a decrease in the efficiency of absorption of the active substance.
According to the instructions for use, you should pay attention to the following effects from simultaneous use with certain groups of drugs:

antiepileptic drugs for simultaneous administration due to a decrease in the effectiveness of antiepileptic therapy;
ascorbic acid and ammonium chloride reduce the effect of amantadine derivatives and reduce the antiviral effect;
aspirin ( various names acetylsalicylic acid and drugs in which it is present), paracetamol and derivatives reduce the effectiveness of this medication by 11% due to the effect on the amount of the active substance entering the systemic circulation;
when combined with sodium bicarbonate and acetolosamide, enhancing the antiviral activity of this drug.

With the onset of cold weather, people start getting flu in droves. How to protect yourself and not catch the virus in autumn and winter? Which drug will help you stay healthy? Tablets "Remantadine" (the international name of the drug "Rimantadine") are an excellent remedy, capable of preventing and treating influenza in adults and children. Today we will consider the following main points regarding this medication: rules of administration, analogues, people’s opinions, cost.

Compound

The drug "Remantadine", the indications for use of which can be read below, has the following structure:

The active ingredient is rimantadine hydrochloride (50 mg).
Auxiliary components - lactose (74.5 mg), potato starch (24 mg), stearic acid (1.5 mg)

Mechanism of action

In order to understand how the antiviral drug “Remantadine” affects the patient, you need to find out how the body is damaged. When a virus enters a cell, it begins to actively multiply within it. Then, when the amount of the pathogen reaches a certain level, the virus leaves the cell and begins to infect a new one, and the previous one, naturally, dies.

The drug "Remantadine" blocks the M2 protein, which is responsible for the reproduction of the virus. As a result infectious agent penetrates the cell, however, it can no longer spread in it. Therefore, for the medicine to work, it must be taken both for prevention and for treatment. It is in the first day that the number of affected cells is small, so the drug will cope well with the virus and will not allow the disease to develop further.

Medicine "Remantadine": indications for use

This remedy is prescribed to eliminate the following ailments:

Flu at an early stage and its prevention;

Tick-borne viral encephalitis;

Release form

The drug is available in 50 mg pills. One package may contain 10, 20, 30, 40 and 50 tablets.

Pharmacokinetics

The drug "Remantadine", reviews of which indicate its effectiveness, is absorbed into digestive tract 2-4 hours after administration. The active substance of the drug is metabolized in the liver. The half-life of the drug from the body is about 30 hours. However, in elderly patients, the release time of the drug increases. But in children, the half-life of Remantadine, on the contrary, decreases.

How to take it correctly?

Patients should swallow the tablets and wash them down with plain boiled water. The medication is taken in courses, and the treatment regimen depends on the age of the patient.

For the treatment of adults, it is used 2 tablets according to the following scheme: 1 day - 3 times; Days 2 and 3 - 2 times; Day 4 - 1 time.

As a therapy for children: 1 pill. For children aged 7 to 10 years - 2 times a day; from 11 to 14 years - three times a day. The duration of treatment should not exceed 5 days.

Side effects

The antiviral drug "Remantadine" when used in some cases can lead to the following undesirable reactions:

From the nervous system. Fatigue, drowsiness, headache, anxiety, difficulty concentrating, increased excitability.
From the digestive organs. Pain in the stomach, nausea, vomiting, flatulence, dry mouth, loss of appetite.
Other side effects: skin rash, itching.

Positive feedback from people

The drug "Remantadine" receives mostly positive reviews from patients. This medication is quite popular. People note the fact that these tablets, when used correctly, really help cope with the flu in its initial stages. Already on the third day after treatment with this drug, patients begin to feel better, the feeling of malaise disappears, headache and fever disappear. The main thing that people advise on numerous forums about the drug “Remantadine” is to follow the instructions, and then the flu will pass quite quickly and without complications.

Also, many positive responses are left by patients who took this drug as a preventive measure. viral diseases. The effect of the drug is especially noticeable in winter period when people start getting flu in large numbers. And then the drug “Remantadine” comes to the aid of patients, which does not give the body healthy person catch a virus.

In addition to the undoubtedly effectiveness of this drug, it has another plus - price. The cost of this medicine is low, which is why people praise it, saying that for such a price the effect is simply amazing. And there is no need to purchase expensive foreign drugs, which, moreover, may not help. It is better to purchase a budget domestic product that will prevent people from getting the flu.

Negative reactions from people

The drug "Remantadine" has not only positive reviews, unfortunately, but also negative ones. Of course, there are few of them, but they still exist. Now let's try to figure out why some patients speak unflatteringly about this remedy.

Patients write that this drug did not help them cope with the flu. However, as the people themselves note, they began therapy with this remedy 3-4 days after the illness. Although the instructions for the drug clearly state that Remantadine tablets effectively fight the influenza virus at its initial stage. Therefore, the desired result was not observed.

Another thing is the dosage regimen. Patients who did not carefully read the instructions or did not open them at all, and did not take the drug according to the schedule, experienced side effects: the appearance skin rash, itching, dizziness, nausea. And such people blamed the medicine “Remantadine” for everything, although in fact the root of the evil was the patients themselves. Therefore, in order to prevent side effects from taking these pills, you must follow your doctor’s instructions and also carefully read the instructions for the medicine. And then negative reviews it won't happen at all.

Similar means

The drug "Remantadine", analogues of which can be purchased at any pharmacy, is dispensed without a doctor's prescription. This drug has several similar effects. So, similar medicine The composition is Rimantadine tablets. This drug has almost the same name, only one letter changes. The only difference is the manufacturer. There are also means where the current active substance the same as in the medicine to which the article is devoted. These are Algirem and Orvirem syrups.

According to the mechanism of influence on the human body, the drug "Remantadine" also has analogues. These are Arbidol capsules, Anaferon pills, Kagocel and Amiksin tablets.

Price

The drug "Remantadine", the price of which is quite affordable, can be purchased for an average of 60 rubles, and this is for a whole package (20 tablets). This drug is a cheap remedy compared to its analogues. Thus, Rimantadine tablets can be bought a little more expensive - on average for 100 rubles. But Algirem and Orvirem syrups are sold for 250 rubles, and Arbidol capsules cost 350 rubles.

Contraindications

To people suffering acute diseases liver, kidneys, you cannot take Remantadine tablets. What this drug can protect from was described above. But in what cases it is prohibited to carry out therapy using this remedy, we will consider below.

The medication is contraindicated for pregnant women and nursing mothers. The drug should not be prescribed to children under 7 years of age. The drug should not be taken by people who are allergic to it.

Particular caution should be used when treating with Remantadine tablets in the following cases:

If the patient has arterial hypertension(applies to older people), since taking these pills can lead to stroke.
For any chronic disease, since this remedy can cause an exacerbation of the disease.

Overdose

If the patient complies with the dosage regimen of the drug "Remantadine" prescribed by the doctor, reviews of which can be read above, then he will not have any health problems. However, if a person violated the procedure for taking this drug and took pills more often, then he may develop such characteristic features overdose: hallucinations, disturbance heart rate, hyperactivity. In this case, the patient must be urgently shown to a doctor, who should provide symptomatic therapy. And before the doctor arrives, the patient’s relatives should help him in the following way: rinse his stomach, give him something to drink activated carbon, provide peace.

Now you know what Remantadine tablets are, what they are prescribed for, and how to take them correctly. We also determined that this drug has analogues, but the drug to which the article is devoted is the cheapest medicine. And the effect of it, judging by numerous reviews from patients, is remarkable.