Benalgin instructions for use, contraindications, side effects, reviews. Side effects of Benalgin

Prohibited during breastfeeding

Has restrictions for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

During illness, a person inevitably faces two symptoms - fever and pain. They are caused by the reactivity of the body and its response to inflammation. By increasing the temperature, the synthesis of interleukins is enhanced, as well as the production of leukocytes is stimulated. Despite this, an increase in body temperature reduces a person’s performance, makes him lethargic and apathetic, and lowers his mood.

A critical increase in temperature above 39 degrees leads to blood thickening and can lead to death.

There are many known ways to combat fever - cold compress, hot tea, however, in this way it will only be possible to alleviate the condition slightly, but not completely cure. For complex action you need to take medications, one of which is Benalgin. This combination remedy, effectively relieving cold symptoms. According to the instructions for use, Benalgin can be used for adults and adolescent children.

General information about the drug

The drug is produced by Bulgarian pharmaceutical company Balkanpharma-Dupnitza, AD. It has analgesic and antipyretic properties, and also has an anti-inflammatory effect. INN – Metamizole sodium+Caffeine+Thiamine. Possessing wide range therapeutic actions, the drug is used in almost all medical fields.

Release forms and prices for the drug, average in Russia

As of today, information about the price of Benalgin in the pharmacy chain in the territory Russian Federation absent. In Ukraine, the drug is sold in price category from 30 to 50 UAH. Below are the average prices for drug analogues that are available in the Russian Federation.

Composition and pharmacological properties

Benalgin consists of three components at once, each of which causes therapeutic effect, complementing and enhancing each other’s action:

The complex effect of the drug provides not only symptomatic relief, but also helps accelerate regeneration processes in the nervous system and restores normal blood supply.

The drug immediately affects 3 links in the occurrence of pain and fever. First of all, there is an effect on the source of inflammation and the level of prostaglandins E2 decreases, then the speed of transmission of the electrical impulse along the sensitive dorsal roots changes. spinal cord, which leads to a decrease in pain.

The narrowing of the lumen of blood vessels prevents the development of edema, and the effect of thiamine is accompanied by pronounced analgesia. Unfortunately, the manufacturer did not provide data regarding the pharmacokinetics of the drug.

Indications and contraindications

Benalgin has the properties of non-steroidal anti-inflammatory drugs and also affects peripheral blood flow, so it can be used in neurology, traumatology, rheumatology and gynecology. The medication is also used after surgical interventions. Indications for taking Benalgin are:

In view of large quantities components, the drug has wide list contraindications:

• hypersensitivity to components drug;
• bronchial asthma;
• anemia;
• leukopenia;
• thrombocytopenia;
• hepatic porphyria;
• uncontrolled arterial hypertension;
• decompensated renal/liver failure;
• sleep disturbance and excessive excitability;
• peptic ulcer of the stomach and duodenum;
• chronic bleeding.

The drug is contraindicated in children under 12 years of age, as well as throughout pregnancy and breastfeeding.

Instructions for use and special instructions

For safe use means it is important to familiarize yourself with detailed instructions on use and rules of safe therapy.

Dosage

The initial dosage for Benalgin is 1 tablet 2-3 times a day for febrile syndrome. At chronic pain It is recommended to take the drug 2 tablets 2-3 times a day. Daily dosage for adults is no more than 6 tablets.

When treating with Benalgin, a number of points must be taken into account:

Possible side effects and overdose

The most common side effect from taking Benalgin is the development of allergic reactions of various types:

• anaphylactic shock;
• Quincke's edema;
• bronchial asthma;
• hives;

With long-term use, there is a violation of the blood coagulation system, disturbance of sleep and the activity of heart rhythm drivers.

An overdose of Benalgin is accompanied by vomiting, nausea, mental agitation, pain in the epigastric region, tachycardia and even development convulsive syndrome. At the first symptoms of an overdose, it is necessary to take the patient to the intensive care unit, rinse the stomach, prescribe sorbents, provide constant control heart activity and respiratory system. There is no specific antidote for Benalgin.

Drug interactions

Benalgin should not be taken with other NSAIDs, as this may potentiate the drugs with each other. It can also lead to the development and progression peptic ulcer stomach and the formation of chronic bleeding.

Tricyclic antidepressants and Allopurinol slow down the metabolism of Benalgin and increase it therapeutic effect. Taking tranquilizers enhances analgesic properties medicinal substances. Reception oral contraceptives reduces the absorption of the drug, thereby reducing its bioavailability.

Similar means

Most often, instead of Benalgin, the following drugs are prescribed:

Sometimes taking multicomponent drugs is contraindicated due to a hyperreaction to its individual components. Therefore, to reduce body temperature, as well as eliminate inflammation of various etiologies, non-steroidal anti-inflammatory drugs are used as monotherapy.

Such drugs have a lower cost, but also less therapeutic activity. However, if there are risks when taking medications in this group, it is easier for the doctor and patient to monitor possible adverse reactions and make timely adjustments.

Compound medicinal product Benalgin

Dosage form

Pharmacotherapeutic group

Pharmacological properties

Indications for use Benalgin

Contraindications

Cautions for use

Interactions with drugs

Side effects

Overdose

Combined analgesics-antipyretics.

Composition Benalgin

Active substance:

• metamizole sodium,
• coffees,
• Thiamine hydrochloride.

Manufacturers

Balkanpharma-Dupnitsa AD (Bulgaria), Farmakhim (Bulgaria), Farmakhim Holding EAD, Pharmacia AD (Bulgaria)

pharmachologic effect

Benalgin is an analgesic non-narcotic drug.

Metamizole sodium has analgesic, antipyretic and anti-inflammatory effects.

Caffeine, which is part of the drug, has some anti-migraine (tones up the blood vessels of the brain) and psychostimulating effect.

Thiamine hydrochloride (vitamin B1) is involved in metabolism and helps improve neuro-reflex regulation.

Side effects of Benalgin

In therapeutic doses, the drug is usually well tolerated.

Sometimes possible allergic reactions (skin rash, itching, Quincke's edema, rarely - anaphylactic shock).

With long-term use, changes in the blood system (thrombocytopenia, leukopenia, agranulocytosis) are possible.

If you are prone to bronchospasm, it is possible to provoke an attack.

Possible sleep disturbances, palpitations, cardiac arrhythmias.

All side effects should be reported to your doctor.

Indications for use

Moderate or mild pain syndrome (headache, toothache, migraine pain, neuralgia, myalgia, joint pain, radicular syndrome, dysmenorrhea).

For mild pain of visceral origin (renal, biliary colic, intestinal spasms) in combination with atropine-like or antispasmodic drugs.

Increased body temperature due to colds and other infectious and inflammatory diseases (if diagnosed).

The advisability of using the drug is decided in each individual case, depending on the severity, nature and tolerance of the fever.

Use as prescribed by a doctor to avoid complications.

Contraindications Benalgin

Hypersensitivity to thiamine, caffeine, metamizole and other pyrazolone derivatives (butadione, tribuzone).

Severe liver or kidney dysfunction.

Bronchial asthma.

Genetic absence of glucose-6-phosphate dehydrogenase.

Diseases of the blood system (leukopenia, agranulocytosis, hemolytic anemia).

Insomnia.

Severe form of hypertension.

Severe symptoms of atherosclerosis.

Increased intraocular pressure.

The period of pregnancy and breastfeeding.

Children under 12 years old.

Directions for use and dosage

Taken orally after meals, 1 tablet 2-3 times in the morning.

Maximum single dose for adults 2 tablets, daily - 6 tablets for no more than 1-2 days.

Duration of administration is no more than 5 days.

Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Dosage for children - children aged 12 to 16 years - half or one tablet 2-3 times a day, maximum daily dose 4 tablets.

Overdose

Signs of acute poisoning are nausea, vomiting, stomach pain, mental and motor agitation, tachycardia, cardiac arrhythmias, possibly decreased diuresis and epileptiform convulsions.

You should seek immediate medical attention.

The victim should undergo gastric lavage and be prescribed adsorbents.

If necessary, carry out symptomatic treatment.

Interaction

The simultaneous use of metamizole with other non-narcotic analgesics and non-steroidal anti-inflammatory drugs can lead to mutual enhancement of toxic effects.

Tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect of metamizole.

The simultaneous use of metamizole with cyclosporine reduces the level of the latter in the blood.

Sedatives and tranquilizers enhance the analgesic effect of metamizole.

When combining BENALGIN with the above and other drugs, consultation and supervision of a doctor is necessary.

special instructions

When taking the drug in the second half of the day, sleep disturbances in the form of difficulty falling asleep are possible.

Use with caution and under medical supervision in patients with impaired liver or kidney function.

With long-term (more than a week) use of the drug, monitoring of the peripheral blood picture and the functional state of the liver is necessary.

For cupping acute pain, reducing inflammation and relaxation smooth muscle Symptomatic therapy drugs can be used.

A popular drug that has a combination effect is Benalgin.

Its action is due to the unique combination of components included in the composition.

But doctors do not recommend taking Benalgin uncontrollably. It is important to adhere to the recommendations specified in the instructions for use. Special attention given if treatment requires combining Benalgin and other medicines.

Instructions for use

Benalgin is an analgesic, antipyretic, and drug that affects the central nervous system.

pharmachologic effect

Benalgin is a combination drug. Metamizole, which is part of it, has antipyretic, analgesic and antispasmodic effect. They relax under its influence smooth muscle gallbladder and urinary tract.

Also, the components of the product have a weak anti-inflammatory effect. The thiamine contained in Benalgin is needed to improve the process of neuro-reflex regulation; caffeine has an anti-migraine effect and a psychostimulating effect.

Metamizole affects enzymes that are responsible for the process of drug absorption. Due to its presence, the pharmacokinetics of the other components of the tablets differ from what they would be if they were taken separately.

Caffeine when ingested, it promotes vasoconstriction, which affects some types of headaches and hypotension. This substance has a slight stimulating effect on the central nervous system. Under the influence of caffeine, the effect of metamizole is enhanced; it can even penetrate into brain tissue.

Vitamin B 1 provides positive influence on the nervous system, eliminating emerging inflammatory processes, enhancing the conduction of nerve impulses.

The tablets are quickly absorbed into the body. The positive effect becomes noticeable within an hour after administration.

Release form, composition

The drug Benalgin is produced in the form tablets.

Each of them includes:

• 500 mg metamizole sodium;
• 50 mg caffeine;
• 38.75 mg thiamine (vitamin B1).

Tablets are packaged in 10 pcs. in cellular packages.

Indications for use

Benalgin is prescribed for various infectious and inflammatory diseases, including colds, which are accompanied by elevated temperature, body aches, weakness.

Use tablets for mild to moderate pain syndrome for these types of pain:

• head;
• dental;
• articular.

They can reduce discomfort with migraine, neuralgia, intestinal, renal, biliary colic, radicular syndrome, and algodismenorrhea. Benalgin alleviates the condition of people with degenerative and inflammatory pathologies of the musculoskeletal system, improves the well-being of patients in the postoperative period.

Neurologists prescribe Benalgin to patients whose peripheral nervous system as a result of progression of radiculitis, neuritis, polyneuropathy, polyneuritis, plexitis.

Directions for use, dosage

Benalgin tablets should be taken after meals, washed down big amount water. In standard cases, adults are prescribed 1 tablet three times a day, but it is advisable to take them all in the first half of the day. If necessary, the dose can be increased, the maximum permissible daily amount is 6 tablets.

Children aged 12-16 years can be given ½–1 tablet three times a day. The maximum allowed quantity is 4 tablets.

The course of therapy with Benalgin should not exceed 3 days.

Interaction with other drugs

Combination with non-steroidal anti-inflammatory drugs, non-narcotic analgesics can lead to a mutual increase in toxic effects on the body.

Oral contraceptives, tricyclic antidepressants, Allopurinol can lead to increased toxicity of metamizole due to disruption of its metabolism in the liver.

Phenylbutazone, drugs from the barbiturate group weaken the effect of metamizole.

Tranquilizers, sedatives may enhance the analgesic effect of Benalgin.

The product reduces concentration cyclosporine. And as part of the blood, it can be dangerous for patients who have transplants.

Side effects

Complications may occur during treatment with Benalgin.

Side effects of the tablets include:

Disturbances in the functioning of the hematopoietic organs usually appear with long-term use of Benalgin. The occurrence of side effects should be reported to the doctor who prescribed the pills.

Overdose

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Next fact

With an overdose of Benalgin, the following symptoms appear::

In case of overdose, it is important that health care was provided immediately. The patient's stomach is washed and adsorbents are given. If necessary, carry out symptomatic therapy.

Contraindications

Before you start taking Benalgin, you should familiarize yourself with the list of contraindications for use.

• insomnia;
• arterial hypertension, which is difficult to control;
• inhibition of the process of bone marrow hematopoiesis;
• diseases of the hematopoietic system (agranulocytosis, leukopenia, hemolytic anemia);
• severe atherosclerosis;
• increased intraocular pressure;
• period of lactation and childbearing.

Tablets are not prescribed to children under 12 years of age.

During pregnancy and lactation

Benalgin is contraindicated in women who are pregnant or breastfeeding..

special instructions

Patients who suffer from atopic bronchial asthma, hay fever, hypersensitivity reactions may develop during treatment with Benalgin. Excessive consumption of tea, coffee and other caffeine-containing drinks during therapy can trigger the development of overdose symptoms.

The pills can interfere with the results of doping tests given to athletes.

Effect on concentration

Patients are advised to refrain from driving vehicles, dangerous mechanisms. You should give up all types of activities that require high concentration attention and requires a high speed of psychomotor reactions.

Use in childhood

Benalgin is not allowed to be given to children under 12 years of age. At the age of 12-16 years, you can give ½-1 tablet.

If kidney function is impaired

For patients with impaired renal function, Benalgin is prescribed with caution. The patient must be under medical supervision during the treatment period.

In case of liver dysfunction

For people whose liver does not perform all its functions, Benalgin tablets are prescribed only if it is possible to organize a permanent medical control for the patient's condition.

Storage conditions and periods

The tablets must be used within 3 years from the date of issue. They should be stored at a temperature of 15-25 °C.

Price

Benalgin is a prescription drug. But it is now difficult to find it for free sale in Russia and Ukraine. The drug is not available in pharmacies.

Analogs

The pharmaceutical equivalent of Benalgin is the drug Sedalgin Plus. These tablets have identical composition. You can buy a pack of 10 tablets of Sedalgin Plus for 95 rubles. The same components are included in the composition of Benamil-M tablets.

Substitutes for Benalgin also include the following drugs::

• Andipal-V;
• Andipal-Extra;
• Andipal-Forte;
• Analgin-Quinine;
• Kofalgin;
• Revalgin;
• 5 giraffe;
• Analgin;
• Antifen IC.

But it is better to select a replacement in consultation with the treating doctor.

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