Advertising on the portal

Instructions for use of Blemaren - how to take this drug correctly.

A drug used to dissolve urinary stones. As a result of establishing the optimal urine pH value when taking the drug, favorable conditions are created to stop the growth and dissolution of uric acid and mixed stones. Reduces the secretion of calcium ions by stimulating the excretion of endogenous citrate, eliminating the conditions for the formation of stones containing calcium and making up the majority of all stones in urolithiasis.
As a result of the metabolism of citrate (a salt of a strong alkali and a weak acid), alkalization (neutralization) of urine occurs. In this case, the citrate residue is oxidized to form CO2 or bicarbonate. Excess alkali, which is formed as a result of the hydrolysis of citrates, is excreted by the kidneys and causes an increase in urine pH.
With oral administration of alkaline citrates (Blemaren citrate complex), dose-dependent neutralization or alkalinization of urine can be achieved. As a result, the degree of dissociation increases, and at the same time, the dissolution of uric acid or cystine. Litholysis of uric acid stones is confirmed by x-ray.
Serum bicarbonate concentration is a regulating factor for citrate secretion by renal tubular cells. With an excess of alkalis and an increase in intracellular pH in the cells of the renal tubules, the tubular metabolism of citrates slows down, reverse resorption decreases and citrate excretion increases. Changes in renal calcium transport as a result of alkalization lead to a significant decrease in urinary calcium excretion.
Alkalinization of urine, increased excretion of citrate and decreased excretion of calcium cause a decrease in the amount of calcium oxalate in the urine, since citrate forms a chemical compound with calcium in a weak alkaline environment. In addition, the citrate ion should be considered as the most important physiological inhibitor of the crystallization of calcium oxalate (as well as calcium phosphate) and the aggregation of these crystals.
Regarding the solubility of cytostatic agents that are excreted by the kidneys, there are similar patterns. It can be assumed that there is a correlation between the aggressiveness of metabolites (for example, cytotoxic drugs such as cyclophosphamide) and the concentration of hydrogen ions in the urine, as well as the pH-dependent solubility of the cytostatic drug or its metabolites in urine (for example, methotrexate).
When taking potassium sodium hydrogen citrate as an adjuvant agent as part of cytostatic therapy, the urine pH should be at least 7.0 in order to sufficiently reduce urotoxicity or nephrotoxic reactions that are caused by chemotherapy.
In skin porphyria tarda there is a deficiency of uroporphyrinogen decarboxylase, which promotes the conversion of uroporphyrinogen to coproporphyrinogen. By means of metabolic alkalization, it is necessary to prevent the reverse diffusion of coproporphyrin in the renal tubules to increase the clearance of coproporphyrin. Due to increased excretion of coproporphyrin, there is an increase in the synthesis of coproporphyrinogen from uroporphyrinogen, and along with this, a decrease in the level of uroporphyrin.
The bioavailability of the drug components is close to 100%. Citrate is metabolized almost completely, only 1.5-2% is excreted unchanged in the urine. When taking 4 effervescent tablets of Blemaren, 38 mmol of citrate enters the body, which corresponds to 2% of the amount of citrate that is metabolized daily in the body.
After a one-day use of the drug Blemaren, the administered amount of sodium and potassium is excreted from the body by the kidneys over 24-48 hours. With prolonged use of the drug, the daily excretion of potassium and sodium corresponds to the daily intake. When using the drug, there are no changes in the gas composition or electrolyte balance of the blood.

Indications for use of the drug Blemaren

Litholysis of urate stones in the urinary tract and prevention of their primary and re-formation; litholysis of mixed urate-oxalate stones; prevention of calcium oxalate stones (prevention of re-formation of stones and growth of residual fragments); alkalinization of urine during cytostatic therapy during the use of uricosuric drugs, during the treatment of patients with cystine stones, as well as in renal tubular acidosis with phosphate lithiasis; as an adjuvant in the treatment of hyperuricemia with xanthine oxidase inhibitors (for example, gout); as an adjuvant in combination symptomatic treatment of skin porphyria tarda.

Use of the drug Blemaren

The average daily dose is determined individually and can be 6-18 g of active substance (2-6 effervescent tablets per day). Effervescent tablets are taken after dissolving in water or fruit juice. The daily dose is divided into 3 equal parts, which are taken throughout the day (for example, at 8.00, 14.00, 21.00).
Monitoring the effectiveness of the drug is carried out by determining the pH of fresh urine 3 times a day before the next dose of the drug. To do this, use standard indicator strips included in each package. The indicator zone of the test strip should be briefly immersed in urine, then removed and after 2 minutes, compare the resulting color of the test strip with the color scale applied to the set of indicator strips, and record the determined pH values ​​in the control calendar. The dose of the drug is considered correctly selected if the pH values ​​determined 3 times a day are within the recommended limits for each pathology. To dissolve urate stones, the urine pH should be between 6.2-6.8. If the daily profile of pH values ​​is below 6.2, the dose should be increased, and if it is above 6.8, the dose should be reduced.
To dissolve urate-oxalate stones and prevent the re-formation of calcium-oxalate stones, urine pH must be maintained for a certain time at a level of 6.8 to 7.4.
Blemaren is used before external nephrolithotripsy for mixed (X-ray heterogeneous) stones to enhance its effectiveness, reduce the structural density of the stone and reduce the frequency of repeated sessions. The duration of therapy to prepare for extracorporeal lithotripsy should be at least 3 weeks.
To alkalinize the urine in patients with cystine stones, the urine pH should be between 7.5 and 8.5. This requires the use of the drug at a higher dose.
When carrying out cytostatic therapy, urine pH should not be lower than 7.0, and when treating late porphyria of the skin - 7.2-7.5.
With uricosuric therapy, as with litholysis of urate stones, the pH should be 6.2-6.8.
pH values ​​that can be determined using standard test strips are in the range of 5.4-7.4. If it is necessary to control urine pH in patients with cystine stones or with late porphyria of the skin, special indicator strips are used to determine the pH in the range of 7.2-9.7 (prescribed additionally by a doctor).
For litholysis of stones (depending on their size and composition), the duration of treatment usually ranges from 4 weeks to 6 months. To prevent relapses of nephrolithiasis, the drug is prescribed in courses, the duration and number of which are determined individually for each patient.

Contraindications to the use of the drug Blemaren

Impaired excretory function of the kidneys, acute renal failure, chronic renal failure in the decompensation phase; acute disturbances of the metabolic rate (metabolic alkalosis); urinary tract infections caused by bacteria that break down urea (risk of struvite stone formation); strict salt-free diet (for example, in severe forms of hypertension (arterial hypertension)); recurrent hyperkalemic paralysis.

Side effects of the drug Blemaren

In some cases, gastrointestinal disorders may occur in patients prone to them (belching, heartburn, abdominal pain, flatulence, diarrhea).

Special instructions for the use of the drug Blemaren

When dissolving urate stones, prolonged excessive alkalization of urine (pH 7.8) should not be allowed, given the possible appearance of a sediment of phosphate salts on the surface of the stone, which may prevent its further dissolution.
The drug can be used for compensated renal failure, which is not accompanied by potassium retention in the body. Before use, it is necessary to determine the level of electrolytes in the blood serum and check renal function. If renal tubular acidosis is suspected, a COR study should be performed.
Patients with heart failure should take into account that 1 effervescent tablet or measuring spoon of the drug contains 380 mg or 9.7 mmol of potassium, which can affect the action of cardiac glycosides (an increase in the extracellular concentration of potassium reduces the effectiveness of glycosides, and a decrease increases the arrhythmogenic effect).
For patients with uric acid metabolism disorders, it is recommended to combine the drug with allopurinol.
Persons who follow a sodium-restricted diet should take into account that 1 effervescent tablet of Blemaren contains 220 mg or 9.7 mmol of sodium.
During therapy with Blemaren, it is recommended to follow a low-protein diet, limiting the consumption of foods rich in purines (meat, sausages, offal, sardines). Every day you need to drink 2-3 liters of liquid in the form of tea, fruit juice or alkaline mineral water in order to reduce the risk of stone formation by producing a sufficient amount of urine.
The drug does not contain carbohydrates and can be used to treat patients with diabetes.
Changes in color of unused test strips do not affect pH results.
When using the drug in accordance with the instructions, no negative effects were observed during pregnancy and lactation.

Interactions of the drug Blemaren

Simultaneous use of drugs containing citrate and aluminum may cause an increase in aluminum resorption, so it is recommended to maintain a 2-hour pause between doses of such drugs.
The drug enhances the therapeutic effect of allopurinol.
Aldosterone antagonists, potassium-sparing diuretics, ACE inhibitors, as well as non-narcotic analgesics and NSAIDs may reduce potassium excretion, which should be taken into account when prescribing Blemaren simultaneously.
With long-term use of Blemaren, accumulation of quinidine in the body is possible if it is taken simultaneously, as well as a decrease in the effectiveness of nitrofurantoin, salicylates and lithium preparations.

Overdose of the drug Blemaren

With normal renal function, metabolic disturbances do not occur in case of overdose. A reduction in the dose of the drug is indicated. Measures are taken to eliminate metabolic alkalosis.

Storage conditions for the drug Blemaren

In a dry place at temperatures up to 30 ° C in tightly closed packaging.

List of pharmacies where you can buy Blemaren:

  • Saint Petersburg

Instructions

The drug is used to dissolve kidney and bladder stones. It has contraindications and side effects, so it should be used as prescribed by a doctor.

Tradename

Blemaren.

Release forms and composition

The drug is produced in different dosage forms.

Effervescent tablets

The tablets are white and round in shape. They are packaged in plastic bottles of 20 pcs. The cardboard box includes 4 bottles and instructions for use. Each tablet contains:

  • citric acid (1.1 g);
  • sodium bicarbonate (967 mg);
  • sodium citrate (835 mg);
  • auxiliary ingredients (mannitol, adipic acid, macrogol, sodium saccharinate, flavor identical to natural).

Granules

Coarse granules for preparing the solution are white in color and have a slight odor. They are packaged in polymer bags of 200 g. The kit includes a measuring spoon, a paper indicator, and a control calendar. 100 g of granules contain:

  • citric acid (40 g);
  • potassium bicarbonate (32 g);
  • sodium citrate (28 g).

pharmachologic effect

The action of Blemaren is restoring the acid-base balance, litholytic.

Pharmacodynamics

The drug is used to treat urolithiasis. Active substances dissolve stones having different compositions. This becomes possible thanks to the alkalinization of urine. The medicine reduces the amount of calcium excreted by the kidneys, which speeds up the process of dissolving oxalates. Suppresses the crystallization of salts, preventing the appearance of calcium oxalate stones.

Pharmacokinetics

Most of the active ingredients penetrate the excretory system, where reabsorption occurs after a few hours. The citrate is then converted to inactive metabolites. Potassium and sodium derivatives leave the body in the urine within 1-2 days. With normal functioning of the kidneys, these substances do not accumulate in the cells and intercellular space.

Indications for use of Blemaren

The drug is used:

  • for the prevention of urolithiasis;
  • to dissolve cystine stones;
  • for splitting calcium oxalate crystals;
  • to eliminate stones having a combined composition;
  • to restore the acid-base balance of urine in patients receiving chemotherapy or taking medications that accelerate the removal of uric acid from the blood;
  • as part of the symptomatic treatment of porphyria.

Contraindications

The drug is contraindicated in the following pathologies and conditions:

  • moderate to severe renal failure;
  • metabolic alkalosis;
  • infectious diseases of the genitourinary system caused by bacteria that destroy urea;
  • severe flu;
  • increased alkalinity of urine;
  • exacerbation of gout;
  • decompensated diabetes mellitus;
  • severe forms of arterial hypertension, requiring abstinence from salt intake;
  • individual intolerance to the ingredients of the drug.

How to take Blemaren

For the prevention of urolithiasis and symptomatic treatment of porphyria, 3 effervescent tablets per day are sufficient. The dose is divided into 3 applications, the medicine is taken after meals. The interval between doses should be at least 5 hours. The dose of the drug is increased if the urine is highly acidic.

For kidney stones

Treatment begins when the urine pH reaches 7-7.2. The daily dose is set taking into account the individual characteristics of the patient’s body and the severity of urolithiasis. In most cases, take 3-5 tablets per day.

Diet when taking Blemaren

Compliance with a special diet during treatment increases the effectiveness of Blemaren. The patient's diet should include:

  • vegetables (carrots, peeled cucumbers, pumpkin, beets);
  • vegetable broths;
  • fruits with a sweet and neutral taste (bananas, peaches, apricots);
  • melons (melons, watermelons);
  • cereals (buckwheat, pearl barley, millet, oatmeal);
  • bakery products made from 2 grades of flour;
  • sea ​​fish;
  • vegetable oils;
  • lard;
  • walnuts and pine nuts.

Completely avoid using:

  • sorrel;
  • parsley;
  • green onions;
  • spinach;
  • spicy vegetables (radish, garlic and onion);
  • Brussels sprouts;
  • bell pepper;
  • sour fruits and berries;
  • chocolate;
  • products containing gelatin.

Side effects

While taking Blemarin, the following may occur:

  • swelling of the lower extremities (associated with sodium retention in the body);
  • cloudy urine;
  • metabolic acidosis;
  • allergic skin rashes;
  • gastrointestinal disorders (nausea, vomiting, loose stools).

Overdose

There is no data on drug overdose.

Drug interactions

When used simultaneously with other drugs, the drug may affect their chemical properties.

Nausea is one of the side effects of the drug.

With other drugs

The simultaneous use of Blemaren and aluminum preparations may increase side effects. Therefore, medications must be taken with a break of 2 hours. The potassium contained in Blemaren may reduce the effectiveness of cardiac glycosides. The removal of potassium from the body is prevented by some diuretics, antihypertensives and non-steroidal anti-inflammatory drugs.

Alcohol compatibility

Taking Blemaren in combination with alcohol does not increase side effects. However, doctors recommend refraining from drinking alcohol during treatment.

Features of application

In some cases, it is necessary to reduce the dose of the drug or stop using it.

During pregnancy and lactation

Studies that can confirm or refute the safety of the drug for the fetus and a child feeding on breast milk have not been conducted. Therefore, the drug is not recommended for use during pregnancy and lactation.

In childhood

For liver dysfunction

Liver diseases are not included in the list of contraindications to the use of Blemaren.

Effect on concentration

The drug does not cause side effects that can affect concentration. It can be taken while driving a car or other vehicles.

Instructions for use of Blemaren effervescent tablets

Blemaren dissolves citrate stones in the kidneys and ureter

The drug Blemaren is intended to dissolve kidney stones formed due to the deposition of calcium salts. It is better not to take this remedy on your own; to prescribe it, you should consult a doctor. The principle of operation of the medicine is based on increasing the pH of urine to a level that dissolves the formed stones. The drug prevents the formation of stones, dissolves those that have arisen, and removes them from the body with urine.

Instructions for use of Blemaren

The drug is a medicinal product; the person taking it must carefully monitor the dosage and period of use. The doctor who prescribed the drug must describe in detail all the necessary measures for the correct use of the drug, since you can take from 2 to 6 tablets per day. The effectiveness of the course of treatment should be regularly monitored by measuring the pH balance of urine, comparing it with a scale and recording the results on paper.

Composition and release form

One tablet of the medicine contains the following active ingredients:

The product is produced in the form of effervescent (soluble) tablets, packaged in a plastic tube of 80 pieces. The package includes a control calendar to help you track your intake period and urine acidity indicator strips. There is also a form of release such as dry powder. Its packaging includes a measuring spoon.

Pharmacodynamics and pharmacokinetics

The active substances of the drug ensure changes in the acid-base balance of urine, increasing its alkalinity (pH level). The process of dissolution of calcium salts in urine improves, which does not lead to the development of urolithiasis. The drug reduces the amount of calcium salts excreted from the body, increases the solubility of calcium oxalate, and inhibits the formation of crystals.

All components that make up the Blemaren tablet are completely absorbed into the body after taking the drug. The action of the substances begins after about 20-30 minutes. Having completed the necessary work with the organs, the active components of the product leave the body along with urine. The type of substances removed does not change, it remains the same.

Indications for use

We can talk about the following indications for use:

  • the need to destroy uric acid and oxalate stones and prevent their occurrence;
  • the need to dissolve stones and their subsequent removal from the urinary system (for stones consisting of at least 25% oxalate salts);
  • increased acidity caused by taking cytostatics and threatening the appearance of stones;
  • therapy for skin porphyria.

How to take Blemaren correctly

Blemaren effervescent tablets are dissolved in any liquid before use. Fruit juice, tea and plain water are suitable. Reception is carried out after meals. As for the dosage of the drug, it depends on the required pH balance level. A value of 6.2-7 is necessary for the destruction of uric acid stones, 7.2-7.5 for the treatment of porphyria, and 7.5-8.5 for the dissolution of cystine stones. The course of treatment is approximately 46 months, during which the acid-base balance of urine must be constantly monitored.

special instructions

While undergoing therapy with this medicine, you need to monitor your diet and reduce the amount of saturated proteins. You should be careful with the dosage for people who are limited in the use of table salt and for those whose pH level exceeded 7 when removing uric acid stones. This can lead to the appearance of phosphate sediment on the stones, which will complicate dissolution. If the patient suffers from renal failure, then taking pills is allowed. During pregnancy and breastfeeding, specialist consultation is required. Your doctor will explain how to use Blemaren for gout.

Drug interactions

Blemaren is not compatible with all drugs. Drugs used to lower blood pressure (aldosterone antagonists, diuretics), analgesics reduce the removal of potassium from the body when taken simultaneously with the drug in question. The potassium content in Blemaren can worsen the effect of using cardiac glycosides. With the simultaneous use of the described drug and preparations containing aluminum, aluminum is quickly absorbed into the body.

Side effects and overdose

Exceeding the dose of the drug leads to metabolic disorders. Using this medicine may cause certain side effects:

  • manifestation of an allergy to any components of the drug, and the degree of manifestation is completely different: from a simple rash and skin itching to anaphylactic shock;
  • metabolic alkalosis;
  • the appearance of swelling of the skin (eyelids and skin around the eyes), the cause of which can be considered sodium retention;
  • dyspepsia.

Contraindications

There are a number of circumstances under which you should refuse to take Blemaren:

  • hypersensitivity to the substances contained in the drug;
  • the presence of metabolic alkalosis, the use of tablets in this case can worsen the condition;
  • renal failure in acute and chronic forms;
  • the development of infections in the urinary organs, which appear due to microorganisms that can break down lactic acid;
  • acid-base balance level is greater than 7;
  • the presence of diseases whose treatment requires adherence to a strict salt-free diet (arterial hypertension).

Terms of sale and storage

The medicine is sold in pharmacies without a prescription, but you should not prescribe it yourself; you should consult your doctor. Storage conditions are not difficult - the location of the tablets should be dry, cool and inaccessible to children.

Analogues

There are some medications that are analogues of Blemaren:

  • Urolesan, which has antiseptic, diuretic effects, relieves spasms. It differs from the drug in question in that it increases the level of urine acid.
  • Cystenal facilitates the passage of small stones. A systematic method helps turn stones into sand.
  • Phytolysin, the action of which is based on the removal of urea from the body and the prevention of the appearance of urinary stones in the kidneys. In addition, it has an anti-inflammatory effect.
  • Uronephron, which helps flush sand and small stones from the kidneys and prevents the crystallization of minerals.
  • K-Na hydrogen citrate increases urine alkalinity. Dissolves stones formed in the urinary organs, then removes them with urine.
  • Soluran, which is useful for urolithiasis. Like many of the remedies presented, it helps dissolve kidney stones and remove them from the body.

Blemaren is considered a drug whose action is aimed at “splitting” or dissolving stones located in the ureters or kidneys.

The drug is used for the treatment of stones in the urinary system.

There are several types of substitutes for this drug available on the market, but you should always consult your doctor before using them.

basic information

The drug is available in the form of large tablets; they are usually dissolved in water before use. When used correctly, the drug has the following effects on the human body:

  • normalizes the acid-base level of urine;
  • promotes the dissolution and removal of stones and sand;
  • prevents the formation of new stones by maintaining normal urine acidity.

Due to its combined action, it is prescribed to patients of various groups; it includes the following components:

  • lemon acid;
  • sodium citrate;
  • sodium bicarbonate.

These are active substances, but they also contain auxiliary substances that do not have a medicinal effect on the human body.

Blemaren is used over a long period of time, the duration of course therapy is determined individually. With long-term use, it is recommended to monitor the acidity level of urine using specialized strips.

In some cases, the use of the drug may not lead to the desired result. The effectiveness of therapy is monitored using appropriate methods ().

During treatment, it is advised to follow a salt-free diet or significantly reduce sodium intake. This will improve the effectiveness of treatment. Will have a positive effect on the effect.

Indications and contraindications

The medicine is used for several purposes; its use is advisable:

  • for kidney diseases, as part of complex therapy;
  • during the presence of stones or sand in the pelvis, bladder;
  • in the presence of high urine acidity (but not higher than 7).

But you should not resort to pills if obstruction has occurred and the ureter has been blocked by a stone. In such a situation, the medication is ineffective, since it is intended for long-term use, and in case of emergency assistance is required.

The following conditions are listed as contraindications:

  • period of pregnancy and lactation (effectiveness in this group of people is unproven);
  • metabolic alkalosis;
  • a history of inflammatory or infectious diseases of the urinary system;
  • hypersensitivity to components, individual intolerance;
  • diseases of the endocrine system (with caution in diabetes mellitus);
  • acute and chronic renal failure with impaired filtration function of organs.

If there are contraindications, the use of tablets is prohibited, since there is a high probability of developing unwanted side effects.

Similar means

There are a number of medications that have a similar effect; their use is agreed with the doctor and is advisable if it is impossible to use Blemaren for one reason or another.

Domestic substitutes

Among modern substitutes we can note

  • Phytolit, which is similar in composition and form of action, is available in capsules, tablets and solution;

Foreign new generation

There are a number of medicines that have a similar effect, but have a different composition compared to Blemaren.

The list of similar analogues can include:

  1. - Available in the form of drops, the drug is classified as a biologically active food supplement, has an anti-inflammatory, diuretic effect. With prolonged use, it dissolves stones and removes them naturally, but is most effective against sand. The cost is 400 rubles.
  2. – a natural, herbal preparation in the form of a paste with a combined effect: it stops the process of inflammation, increases the outflow of urine, and promotes the dissolution of stones. The medicine is produced in Poland. It is used to treat urolithiasis, but only in combination with other medications. The cost is 500 rubles.
  3. – a drug in tablet form, produced in India, consists of herbal components, is used in urology and nephrology to treat diseases of inflammatory, infectious and other nature. In particular, it is prescribed during the treatment of urolithiasis, in order to dissolve and remove formed sand particles or small stones from the body. The cost of the medicine is 390 rubles.
  4. Quote.
  5. Citrokas.

Instructions for use. Contraindications and release form.

Instructions
on medical use of the drug
Blémarin


Dosage form:

Granules for the preparation of solution for oral administration;

Effervescent tablets.

Compound:

100 g of the drug contains:

Citric acid - 39.90 g

Potassium bicarbonate - 32.25 g

Sodium citrate - 27.85 g

Excipients: none

Effervescent tablets:

1 tablet contains:

Citric acid - 1197.0 mg

Potassium bicarbonate - 967.5 mg

Sodium citrate - 835.5 mg

Description:

Granules for the preparation of solution for oral administration:

Coarse white granules with a slight odor

Effervescent tablets:

White, round, flat, faceted tablets with a lemon scent.

Pharmacotherapeutic group: treatment for nephrolithiasis.

ATX code: G04BC

Pharmacological properties:

Dissolves and prevents the formation of uric acid stones by alkalinizing urine to pH values ​​of 6.6 - 6.8 (with urine pH in the range of 6.6 - 6.8, the dissolution of uric acid salts significantly increases). In addition, it reduces calcium excretion, improves the solubility of calcium oxalate in urine, inhibits the formation of crystals and, therefore, prevents the formation of calcium oxalate stones.

Pharmacokinetics. Bioavailability is about 100%. Excreted by the kidneys.

Indications for use:

Dissolution of uric acid and calcium oxalate stones and prevention of their formation;

Dissolution of mixed uric acid-oxalate stones (with an oxalate content of less than 25%);

Symptomatic treatment of skin porphoria.

Contraindications:

Hypersensitivity;

Acute and chronic renal failure;

Metabolic alkalosis;

Urinary tract infections caused by microorganisms that break down urea;

Urine pH is above 7;

The need to adhere to a strictly salt-free diet (for example, in severe forms of arterial hypertension).

Directions for use and dosage:

Granules for the preparation of solution for oral administration:

Before ingestion, the granulated powder is dissolved in 200 ml of liquid (tea, fruit juices, or alkaline mineral water). Daily dose - 6-18 g (2 - 6 measuring spoons). One measuring spoon contains 3 g of granulated powder.

Effervescent tablets:

Before oral administration, the tablets are dissolved in 200 ml of liquid (tea, fruit juices, or alkaline mineral water). Daily dose - 2-6 tablets.

The daily dose is distributed evenly throughout the day and taken after meals. The dose is considered correctly selected if the pH during the day is in the range of 6.2-7.0 (to dissolve uric acid stones); 7.5-8.5 (for cystine stones); 7.2-7.5 (for the treatment of porphoria); at least 7.0 (when treated with cytostatics). If the pH value of the urine is lower than specified, the dose must be increased, if higher, it must be reduced. Duration of treatment is 4-6 months.

Efficiency monitoring (determination of urine pH) is carried out 3 times a day, before taking each single dose, using indicator paper. the resulting color on paper is compared within 2 minutes with the scale and the resulting value is entered into the control calendar.

In the presence of cystine stones and treatment of porphoria, special indicator paper with a pH value of 7.2 to 9.7 should be used to monitor effectiveness.

Side effect:

Allergic reactions, edema (sodium retention), metabolic alkalosis, dyspepsia.

Interaction with other drugs:

Concomitant use of drugs containing citrates and aluminum may lead to increased absorption of aluminum. The interval between doses of such drugs should be at least 2 hours.

The effect of cardiac glycosides may be weakened when combined with Blemaren, due to the presence of potassium in the drug.

Some drugs that lower blood pressure (aldosterone antagonists, potassium-sparing diuretics, angiotensin-converting enzyme blockers), as well as non-steroidal anti-inflammatory drugs and analgesics can reduce potassium excretion. The possibility of simultaneous use of such drugs is determined by the doctor.

Special instructions:

The average daily dose (12 g of granular powder or 4 effervescent tablets) contains about 1.5 mg of potassium and 0.9 mg of potassium (should be taken into account in patients with limited salt intake). Can be used for chronic renal failure not accompanied by potassium ion retention. Can be prescribed to patients with diabetes. When dissolving uric acid stones, the daily dose should not be exceeded, since when the pH increases above 7.0, phosphates precipitate on the uric acid crystals, which prevents their further dissolution. During treatment, you should limit your intake of foods rich in proteins and purine bases, and ensure sufficient fluid intake (at least 1.5-2 liters).