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The drug "Metronidazole" is an analogue of "Trichopol." Trichopolum analogues and distinctive features of various forms

Trichopolum is a highly effective antimicrobial drug. This has made it popular among doctors of various specialties who use the product in their practice. At the same time, pharmaceutical market offers patients large number analogues of this remedy. They all differ significantly - in price, appearance packaging, release form, country of origin. But they have the same active ingredient – ​​metronidazole.

Are there any significant differences between the means? Is it possible to replace one drug with another of similar composition? Will the analogue be as effective? This will be discussed in today's article.

Trichopolum is an antimicrobial medicine that is active against protozoa - Trichomonas, Gardnerella, Giardia. In addition, the product is used to treat diseases caused by obligate anaerobic microorganisms.

Trichopolum is an antiprotozoal drug with an antimicrobial effect

The main ones include:

  • clostridia;
  • peptococci;
  • peptostreptococci;
  • bacteroides;
  • fusobacteria;
  • Veillonella.

The active ingredient is metronidazole. It interacts with the DNA of pathogenic microorganisms, inhibiting its synthesis. This causes the death of pathogens.

Trichopolum is quickly absorbed into gastrointestinal tract patient. The maximum concentration in the blood is observed within two hours after administration. The drug penetrates well into all tissues and biological fluids, including breast milk. 80% of the drug is excreted in the urine, the rest in feces. U healthy person the half-life is 8 hours. In case of liver pathology, which is accompanied by functional failure of the organ, this period increases. Trichopolum is also used in the form vaginal tablets, exerting a local effect on the body.

In general, Trichopolum is well tolerated. From side effects The most common symptoms are nausea, dizziness, allergic reactions, disorders of the digestive tract. The drug should not be used to treat pregnant women and during lactation, as well as patients with liver failure.

Domestic analogues

The most common analogue of trichopolum is metronidazole. It is produced at numerous pharmaceutical factories in our country.

The main forms of release include tablets and injection solution. One metronidazole tablet may contain 250 or 500 mg of active ingredient. One bottle contains 100 ml of 0.5% solution for injection. That is, each milliliter of the drug contains 5 mg of metronidazole.

Metronidazole is a cheaper analogue expensive drug Trichopolum

The drug has optimal pharmacokinetic properties. Its bioavailability, that is, the ability to reach the site of the disease, ranges from 80 to 100% compared to the concentration of the drug in the blood plasma. In the cerebrospinal fluid this figure is slightly lower. This allows the use of tablet forms of the product. TO injection forms resorted only in cases of severe illness.

Like Trichopolum, metronidazole penetrates well into all fluids and tissues of the body, reaching its maximum concentration within 2 hours after administration. The half-life ranges from 6 to 10 hours. It increases in patients with liver failure. The drug freely passes through the hematoplacental and blood-brain barrier.

Foreign analogues

The most popular foreign analogues of Trichopolum include:

  • Flagyl;
  • Metrogil;
  • Klion;
  • Metroxan;
  • Deflamon.

Flagyl is a more expensive analogue of Trichopolum produced in France

Flagyl is an original drug manufactured in France. This is the most expensive of all drugs containing metronidazole. Metrogyl - produced in India. Relatively low cost, combined with good tolerability and high efficiency, made this product one of the most popular analogues original drug. Klion is also a highly effective medicine. Produced in Hungary. Metroxan is another French drug. Deflamon is produced in Italy.

Like Trichopolum, all these drugs penetrate well into all organs and tissues of the body, reaching bactericidal concentrations where it is required.

Klion D belongs to the antiprotozoal drugs

Like Trichopolum, it foreign analogues are available in the form of tablets and solutions for injection. In addition, foreign companies produce local forms of the drug. These include:

  • vaginal suppositories;
  • vaginal tablets;
  • vaginal gel;
  • cream and gel for external use.

Metrogyl - vaginal gel

Thanks to their local effect, they have a detrimental effect on the pathogen where it is needed most. At the same time overall impact on the body is minimal, as is the risk of side effects.

Advantages and Disadvantages

Despite the fact that the active substance of the drugs is the same, it cannot be said with certainty that they all have absolutely the same effect on human body. Each of the analogues has its own advantages and disadvantages.

Domestic products differ from Trichopolum in their rather low cost. In some cases it can be 10 times lower. But this does not mean at all that regular metronidazole will be less effective than imported one.

Among the shortcomings domestic drugs You can highlight the very bitter taste of the tablets and the not very aesthetic packaging. The latter fact is one of those that explains the low cost of domestic drugs.

All analogues of foreign production differ, first of all, at a high price. This is their main disadvantage. For this reason, they are relatively rarely prescribed by domestic doctors, who, among other things, take into account the financial capabilities of patients.

Analogue drugs are similar in indications for use and their pharmacological action

The advantage of foreign medicines is the presence of a shell on the tablets. This reduces taste sensations in the patient, but significantly increases the cost. In addition, practicing doctors tend to believe that foreign-made drugs are much better tolerated by patients. They explain this by a more advanced production process and a high degree of purification of the active substance.

Another advantage of foreign analogues is the availability local forms. Thanks to them, there is no need to prescribe pills to a patient with colpitis. Instead, doctors recommend vaginal suppositories and gel. Cream and gel for external use are used for treatment acne in adolescents, rosacea, fissures anus, wounds, bedsores, trophic ulcers.

Final decision on appointment medicinal drug is taken by the attending physician. Only he can take into account all the subtleties and make right choice. Changing the drug yourself can lead to a lot of adverse events. Unsatisfactory treatment results are one of them. If the patient has any doubts or questions, he should discuss them with the doctor. This will allow you to get good result to the maximum short terms, with the least risk of side effects.

IN medicine Trichopolum's most important component and active ingredient is metronidazole. This remedy is antimicrobial, antiprotozoal. Directions for use:

  • Oral. Ingestion of tablets.
  • Intravenous. Administration by injection.
  • Superficial. Applying ointment to the skin surface.
  • Vaginal. Application vaginal suppositories.

This drug has a wide range of applications, but in most cases it is used to combat:

It can be used to treat diseases such as:

  • Trichomoniasis.
  • Bacterial vaginitis.
  • Sepsis.
  • Peritonitis.
  • Giardiasis.
  • Amoebiasis.

Contraindications to taking Trichopolum and side effects

The use of Trichopolum has its contraindications, these include:

Trichopolum acts not only on harmful microorganisms, but also on beneficial ones that are constantly present in the human body. It reduces acidity, which causes the development of an alkaline environment, which promotes the growth of dangerous fungi. This can cause thrush. When taking the drug, dizziness appears and the reaction slows down, so people working with machines and mechanisms, car drivers should be careful when taking this medicine.

Substitutes for Trichopolum

The presence of side effects and contraindications to taking Trichopolum lead to the fact that when treating the disease, it is necessary to find a replacement drug. What means can replace it? Main component Trichopolum is metronidazole, so when replacing it, you should use drugs that do not contain this component. If the patient has an intolerance to substances included in the medicine or the listed diseases, then the doctor must be warned about this. Remember that only he can decide which drug should be used.

Let's consider Trichopolum substitutes, which are prescribed for the above diseases.

Clindamycin is a drug group-owned antibiotics Lincosamides. The drug Clindamycin, like Trichopolum, actively treats diseases caused by anaerobic bacteria. These include bacterial vaginitis caused by simple gardnerella.

Clindamycin and its analogues should be taken as prescribed by a doctor. He must also draw up a schedule for taking the medication and dosage. Release form:

  • capsules for oral use;
  • solution for intramuscular and intravenous injections;
  • suppositories used vaginally;
  • ointment.

When using tablets and capsules, it is better to take Clindamycin with water. small quantity. Additionally, in consultation with your doctor, take pathogenetic agents. Clindamycin has quite a few contraindications:

  • individual intolerance to individual components of the drug;
  • kidney and liver diseases;
  • pregnancy and lactation;
  • children under 1 year of age;
  • advanced age;
  • asthma;
  • stomach ulcer.

The drug Doxycycline is part of the tetracyclines. Its use has a wide spectrum of action. Doxycycline fights a large number bacteria, including microplasmas, which cause most genitourinary diseases, as well as chlamydia, which provokes an infection of the reproductive system. The main substance of the drug is tetracycline.

The principle of action of Doxycycline, like Clindamycin, Trichopolum, is the same. To break into the bacterial cell and destabilize protein synthesis, thereby leading to its death. Its concentration in the blood remains for a day, this allows you to take Doxycycline tablets once a day. Release form: tablets and solution for intramuscular administration.

This drug has much fewer contraindications for use than its analogue, tetracycline. Their list includes:

  • Sensitivity to tetracycline.
  • Liver diseases.
  • Increased number of porphyrins in the blood.
  • Reduced number of leukocytes.
  • Pregnancy.
  • Children's age up to 8 years.

Clotrimazole is a synthetic medical product, used to treat diseases caused by fungi. Available in the form of vaginal tablets, creams and ointments, and solution. Used together with Clindamycin and Trichopolum in case of thrush. The tablets are inserted into the vagina using an applicator at night. The duration of treatment is 6 days. Clotrimazole can be used strictly as prescribed by the doctor.

Amoxiclav is a combination drug based on amoxicillin and clavulanic acid. Amoxicillin is a semi-synthetic penicillin. This is an antibiotic with a wide range of applications. Amoxiclav acid actively treats diseases caused by anaerobic bacteria. Amoxiclav is used for gynecological infections and can serve as a substitute for Trichopolum. Produced by various manufacturers in the form of:

  • powder for injections;
  • powder for making a suspension for internal use;
  • film-coated tablets.

The use of Amoxiclav simultaneously with ascorbic acid increases its absorption. Treatment with Amoxiclav should be carried out strictly as prescribed by the doctor, in compliance with the prescribed dosage. The drug has a number of contraindications:

  • Individual intolerance to the components of Amoxiclav.
  • Liver disorders.
  • Lymphocytic leukemia.
  • Infectious mononucleosis.

Tinidazole is a drug that fights anaerobic infections such as gardnerella, which causes bacterial vaginosis. It is very quickly absorbed into the gastrointestinal tract, transported throughout the body and concentrated at the site of infection. The principle of action of Tinidazole is similar to Trichopolum and Clindamycin: penetration into the bacterial cell and destruction of DNA.

It accumulates in the zone of dysbacteriosis. It is removed by the kidneys and passes through the liver. Therefore, Tinidazole is not recommended for use by people suffering from diseases of this organ. Take only with a doctor's prescription. The release form of Tinidazole is film-coated tablets. This drug has contraindications:

  • Time of pregnancy and breastfeeding.
  • Diseases of the hematopoietic organs.
  • Diseases of the nervous system.

Terzhinan contains neomycin sulfate - active substance, which helps in the fight against gardnerella, which causes bacterial vaginosis. It is produced in the form of suppositories inserted into the vagina. Effective drug, allowing for short time get rid of infection.

Usually the doctor prescribes a course of treatment for a period of 10 days. The drug must be inserted into the vagina before bed, after moistening it with water. Perform treatment regularly, without stopping it even during menstruation. The presence in the drug of a strong hormonal agent makes its use unacceptable for pregnant women. Often when treating with Terzhinan suppositories, it is prescribed joint use with Trichopolum. Use the drug only as prescribed by a doctor.

When using Terzhinan at the beginning of treatment, a burning and itching sensation is felt in the genitals, which means active influence drug for infection. To prevent a recurrence of the disease, it is necessary for both partners to undergo treatment.

Tiberal – drug with antibacterial and antiprotozoal effects. It actively fights the simplest anaerobic bacteria, including gardnerella, which causes bacterial vaginosis. The drug penetrates into the blood as quickly as possible: after 3 hours after administration, the substance accumulates in the plasma.

Tiberal fights well against anaerobic infection due to the presence of Ornidazole in its composition. Its half-life lasts 13 hours. Tiberal should be taken after meals. The appointment is carried out twice a day, the course of treatment lasts up to 7 days. Contraindications:

  • Pregnancy (first trimester).
  • Breastfeeding period.
  • Hematological pathologies.
  • Diseases of the central nervous system.
  • Intolerance to the components of the drug.

Tsifran – antimicrobial drug expanded scope. Part of the group of quinolones. It contains ciprofloxacin. It acts similarly to Trichopolum and Clindamycin. Increases the permeability of bacterial cell membranes and has a pronounced antibacterial effect. It has a detrimental effect on aerobic bacteria of various kinds.

At the same time, the instructions for its use note a certain resistance to the drug. One can note its positive property - it does not have a detrimental effect on the microflora of the intestines and vagina. Available in:

  • Film-coated tablets.
  • Solution for injection.
  • Eye drops.

The drug should be used only as prescribed by a doctor, as it has a number of contraindications:

  • Atherosclerosis of cerebral vessels.
  • Cerebral circulatory disorders.
  • Mental disorders.
  • Epilepsy.
  • Hepatic and renal pathology.
  • Advanced age.

It is recommended to use simultaneously with the drug acetylsalicylic acid in order to improve blood properties, as well as against platelet aggregation. The dosage and duration of administration are prescribed strictly individually. This takes into account: the severity of the disease, body weight, type of pathogen, age of the patient, condition of the liver and kidneys.

Another antibacterial drug is Levomycetin. Its scope is quite wide. It has proven itself in the treatment of diseases caused by chlamydia, spirochetes, brucella, hemophilus influenzae, and rickettsia.

But Levomycetin exhibits weak activity against protozoa, so it is prescribed for individual intolerance to other drugs. Levomycetin is available in the form:

  • Tablets that contain the main substance Levomycetin and additionally starch and stearic acid.
  • Powder for injection.
  • Eye drops.

Contraindicated in case of intolerance to the drug, diseases of the hematopoietic organs, skin diseases. Due to the small list of contraindications, Levomycetin is used in pediatrics. Widely used in ophthalmology.

Ivan Georgievich Safonov

The drug Trichopolum has various analogues. They have the same generic, international name or code. If a doctor has prescribed Trichopolum to a patient, it is prohibited to independently select analogues. This should only be done by the attending physician, because he knows the peculiarities of the course of the disease and the characteristics of the drugs.

Possible options

An excellent substitute for Trichopolum is the drug Dazolic. The cost of this medicine is slightly higher. It is indicated for use in a number of cases, including:

  • amoebic dysentery;
  • amoebiasis;
  • amoebic liver abscess and other extraintestinal forms of the disease;
  • giardiasis;
  • colon surgery;
  • prevention of infection caused by anaerobic bacteria;
  • performing gynecological operations.

The drug Infezol can be a substitute. High effectiveness of the drug is observed during therapy against infections ( severe forms), which constitute a significant threat human life. Such diseases are caused by pathogenic microorganisms that are highly sensitive to the substance metronidazole.

These are infections that affect the lower respiratory tract, for example, empyema, pulmonary abscess, destructive pneumonia. Infezol copes with pathologies such as peritonitis, sepsis, abscess abdominal cavity, liver, pelvic organs. Treatment is carried out if a woman has an infection after giving birth.

Infezol is indicated for the treatment of infectious diseases affecting the central nervous system. For example, brain abscess, meningitis. The effectiveness of the drug is manifested against osteomyelitis, gas gangrene, and septicemia.

The drug relieves the patient from amoebic liver abscess, intestinal amebiasis in acute form. It can be used for preventive purposes if complications are identified after surgery that are caused by anaerobic pathogenic bacteria.

Substitutes for the drug are Meradazole, Meratin. The latter remedy is indicated for use in the following cases:

  • amebiasis (intestinal and extraintestinal form);
  • trichomoniasis;
  • Giardiasis

It is permissible to use medication to achieve preventive measures, if they arise postoperative complications. The cost of the drug is relatively high.

Other options

If there are contraindications or the development of side effects after using the drug Trichopolum, you can use the drug Metrid. It must be prescribed by a doctor.

Metrid is recommended to eliminate severe infectious diseases caused by anaerobic bacteria that are sensitive to the active component of the drug. Good results are observed in the treatment of infections mixed form. In such cases, the medication is prescribed in conjunction with antibacterial drugs, which are characterized by effectiveness against microbes.

The use of the drug is indicated in the presence of abdominal infections in the body, for example, treatment of peritonitis.

Due to its combination of properties, Metrid is popular in the fight against gynecological infections, diseases affecting the central nervous system, respiratory tract, bones, and joints. Treatment of wounds that have become infected is indicated if they occur after surgery. It is also used for preventive purposes if the patient has experienced surgery to the authorities digestive system or small pelvis.

It is permissible to replace Trichopolum with the medicine Metressa. Indications for the use of this medication are similar to those presented in the instructions for to the original remedy. Due to the action of the drug, it manifests itself high efficiency against infectious diseases affecting the lungs, pleura, and central nervous system. A remedy is often prescribed against infectious disorders that affect the ENT organs and the oral cavity.

Metronidazole can be prescribed as an analogue of Trichopolum. It is capable of effectively combating a whole range of infections. It is used for therapy peptic ulcer stomach, duodenum, other diseases. Metronidazole is often used for prophylaxis when indicated. Other medications that are excellent substitutes for Trichopolum: Orzol, Tricaside, Ornigil, Ornidazole, Efloran, etc.

Regardless of the analogue chosen, you should consult your doctor.

Each of the above drugs has its own characteristics and can be prescribed as a substitute only in certain cases. Thoughtless use of medicines is strictly prohibited.


Comments

    Megan92 () 2 weeks ago

    Daria () 2 weeks ago

    Previously, they poisoned themselves with chemicals like Nemozod and Vermox. The side effects I had were terrible: nausea, stool disturbances, and a sore mouth, as if from dysbacteriosis. Now we are taking TOXIMIN, it is much easier to tolerate, I would even say without any side effects. Good remedy

    P.S. Only I’m from the city and couldn’t find it in our pharmacies, so I ordered it online.

    Megan92 () 13 days ago

    Daria () 12 days ago

    Megan92, I already indicated) Here I am attaching it again - TOXIMIN official website

    Rita 10 days ago

    Isn't this a scam? Why do they sell on the Internet?

    Yulek26 (Tver) 10 days ago

    Rita, it’s like you fell from the moon. Pharmacies are grabbers and even want to make money from it! And what kind of scam can there be if payment is made after receipt and one package can be received for free? For example, I ordered this TOXIMIN once - the courier brought it to me, I checked everything, looked at it and only then paid. At the post office it’s the same, there is also payment upon receipt. And now everything is sold on the Internet - from clothes and shoes to equipment and furniture.

    Rita 10 days ago

    I apologize, I didn’t notice the information about cash on delivery at first. Then everything is fine if payment is made upon receipt.

    Elena (SPB) 8 days ago

    I read the reviews and realized that I had to take it) I’ll go place an order.

    Dima () A week ago

    I ordered it too. They promised to deliver within a week (), so let's wait

    Guest A week ago

    How do you determine that you have worms? Do you diagnose yourself and treat yourself? Go to the doctor, get tested, let them prescribe you competent treatment. A whole council was assembled here, and they advised themselves without knowing what!

    Alexandra (Syktyvkar) 5 days ago

    Guest, don't get so excited. It’s one thing when people on the Internet ask how to treat hemorrhoids. folk remedies, but it’s completely different when they share their experience of taking dietary supplements. No one here will give you bad advice. It wouldn't hurt for you to check yourself. Unfounded neuroses are the first sign helminthic infestation

    Margo 6 days ago

    I took this drug... several hours have already passed... but there is no urge to go to the toilet... nothing comes out (((((

In this article you can find instructions for use medicinal product Trichopolum. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Trichopolum in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications were observed and side effects, perhaps not stated by the manufacturer in the annotation. Analogues of Trichopolum in the presence of existing structural analogues. Use for the treatment of vaginosis, trichomoniasis and other infectious diseases in adults, children, as well as during pregnancy and lactation. Drug dosage regimen.

Trichopolum- antiprotozoal drug with antibacterial activity, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole (the active ingredient of the drug Trichopolum) by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of microbial cells, inhibiting their synthesis nucleic acids, which leads to the death of microorganisms.

In combination with amoxicillin, it is active in regarding Helicobacter pylori (amoxicillin suppresses the development of resistance to metronidazole).

Metronidazole has no effect bactericidal action against most bacteria and facultative anaerobes, fungi and viruses. In the presence of mixed flora (aerobes and anaerobes), metronidazole exhibits synergism with antibiotics that are effective against common aerobes.

Metronidazole increases the sensitivity of tumors to radiation, causes sensitization to ethanol (alcohol) (disulfiram-like effect), and stimulates reparative processes.

Pharmacokinetics

After taking the drug orally, metronidazole is quickly and almost completely absorbed from the gastrointestinal tract. Eating reduces the rate of absorption and Cmax of metronidazole in the blood serum. Metronidazole penetrates into most body tissues and fluids, including lungs, kidneys, liver, skin, cerebrospinal fluid, brain, bile, saliva, amniotic fluid, abscess cavities, vaginal secretions, seminal fluid, breast milk, penetrates the BBB and the placental barrier. The main metabolite (2-oxymetronidazole) also has antiprotozoal and antibacterial effects. Metronidazole is excreted by the kidneys - 60-80% (20% unchanged), through the intestines - 6-15%.

In elderly patients, renal excretion of metronidazole is reduced.

Indications

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

  • trichomoniasis;
  • bacterial vaginosis;
  • all forms of amebiasis (diseases of intestinal and extraintestinal localization, including amoebic liver abscess, amoebic dysentery, as well as asymptomatic amebiasis);
  • giardiasis;
  • periodontal infections (including acute ulcerative gingivitis, acute odontogenic infections);
  • anaerobic bacterial infections(gynecological and abdominal infections CNS, bacteremia, sepsis, endocarditis, infections of bones and joints, skin and soft tissues, infections respiratory tract), caused by Bacteroides spp., Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp. and anaerobes sensitive to metronidazole;
  • treatment of Helicobacter pylori infections in gastric or duodenal ulcers in combination with bismuth preparations and an antibiotic, for example, amoxicillin;
  • prophylactic appointment before surgical intervention on the gastrointestinal tract and reproductive organs.

Release forms

Tablets 250 mg.

Vaginal tablets (popularly called suppositories for some reason) 500 mg.

Instructions for use and dosage regimen

The drug is prescribed orally, during or after meals, the tablets are taken without chewing.

Trichomoniasis

Adults and children over 10 years of age are prescribed 250 mg (1 tablet) 3 times a day or 500 mg (2 tablets) 2 times a day for 7 days. Women must additionally be prescribed metronidazole in the form of vaginal suppositories or tablets. If necessary, you can repeat the course of treatment. Between courses you should take a break of 3-4 weeks with repeated control laboratory tests.

An alternative treatment regimen is to prescribe 750 mg (3 tablets) in the morning and 1250 mg (5 tablets) in the evening or 2000 mg (8 tablets) per day once. The duration of treatment is 2 days. Treatment is carried out simultaneously for both sexual partners.

Children aged 3 to 7 years are prescribed 125 mg (1/2 tablet) 2 times a day; aged 7 to 10 years - 125 mg (1/2 tablet) 3 times a day. The course of treatment is 7 days.

Bacterial vaginosis

Adults are prescribed 500 mg (2 tablets) 2 times a day for 7 days or 2000 mg (8 tablets) per day once. Simultaneous treatment of the sexual partner is not required.

Amoebiasis

For invasive forms of intestinal amebiasis in susceptible patients (including amoebic dysentery), adults and children over 10 years of age are prescribed 750 mg (3 tablets) 3 times a day. Children aged 3 to 7 years - 250 mg (1 tablet) 4 times a day; at the age of 7 to 10 years - 375 mg (1.5 tablets) 3 times a day. The course of treatment is usually 5 days.

For intestinal amebiasis in less susceptible patients and for chronic amoebic hepatitis, adults and children over 10 years of age are prescribed 375 mg (1.5 tablets) 3 times a day. Children aged 3 to 7 years - 125 mg (1/2 tablet) 4 times a day; aged 7 to 10 years - 250 mg (1 tablet) 3 times a day. The duration of treatment is 5-10 days.

For amoebic liver abscess and other forms of extraintestinal amebiasis, adults and children over 10 years of age are prescribed 375 mg (1.5 tablets) 3 times a day. Children aged 3 to 7 years - 125 mg (1/2 tablet) 4 times a day; at the age of 7 to 10 years - 250 mg (1 tablet) 3 times a day. The course of treatment is 5 days.

For asymptomatic carriage of cysts, adults and children over 10 years of age are prescribed 375-750 mg (1.5-3 tablets) 3 times a day. Children aged 3 to 7 years - 125 mg (1/2 tablet) 4 times a day; at the age of 7 to 10 years - 250 mg (1 tablet) 3 times a day. The duration of treatment is 5-10 days.

Giardiasis

Adults and children over 10 years of age are prescribed 500 mg (2 tablets) 2 times a day for 5-7 days; or 2000 mg (8 tablets) 1 time per day for 3 days.

Children aged 3 to 7 years - 250-375 mg (1-1.5 tablets) 1 time per day for 5 days, or 500-750 mg (2-3 tablets) 1 time per day for 3 days. Children aged 7 to 10 years - 250 mg (1 tablet) 2 times a day for 5 days, or 1000 mg (4 tablets) 1 time a day for 3 days.

Infections caused by anaerobic bacteria

Treatment anaerobic infections usually start with intravenous infusions. As soon as possible, treatment should be continued with metronidazole tablets.

Adults and children over 10 years of age are prescribed 500 mg (2 tablets) 3-4 times a day. The duration of treatment should not exceed 7 days.

For children under 10 years of age, the use of metronidazole in the form of infusion solutions is recommended for the treatment of anaerobic infections.

Helicobacter pylori eradication

Prescribe 500 mg (2 tablets) 3 times a day for 7 days (in the composition combination therapy, for example, with amoxicillin 2.25 g/).

Suppositories or vaginal tablets

Intravaginally (deeply), after first releasing the tablet from the contour packaging and moistening it with boiled cooled water.

Trichomonas vaginitis: 1 tablet/day for 7-10 days in combination with taking the drug orally.

Nonspecific vaginitis, bacterial vaginosis: 1 tablet/day for 7 days (if necessary, combined with oral administration of the drug). The course of treatment is no more than 10 days and no more than 2-3 times a year.

Side effect

  • epigastric pain;
  • nausea, vomiting;
  • diarrhea, constipation;
  • intestinal colic;
  • decreased appetite;
  • anorexia;
  • taste disturbance;
  • dry mouth;
  • headache;
  • dizziness;
  • increased excitability, irritability, depression;
  • sleep disturbance, drowsiness;
  • hallucinations;
  • convulsions;
  • urinary incontinence;
  • red-brown coloring of urine;
  • excessive development of vaginal fungal flora (including vaginal candidiasis);
  • skin rash, itching, urticaria;
  • arthralgia;
  • leukopenia, agranulocytosis, neutropenia, thrombocytopenia;
  • pustular rashes.

Contraindications

  • leukopenia (including history);
  • organic lesions of the central nervous system (including epilepsy);
  • liver failure (if the drug is prescribed in high doses);
  • 1st trimester of pregnancy;
  • lactation period ( breast-feeding);
  • children under 3 years of age;
  • hypersensitivity to metronidazole or other nitroimidazole derivatives.

Use during pregnancy and breastfeeding

Metronidazole penetrates the placental barrier, therefore Trichopolum is contraindicated for use in the 1st trimester of pregnancy. The use of the drug in the 2nd and 3rd trimesters is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

Since metronidazole is released from breast milk, reaching concentrations in it close to the concentration in the blood plasma, if it is necessary to use Trichopolum during lactation, breastfeeding should be stopped.

Special instructions

Trichopolum should be prescribed with caution to patients with severe liver failure, because as a result of a slowdown in metabolism, the concentration of metronidazole and its metabolites in plasma increases.

Caution is required when prescribing Trichopolum to patients with suppression of bone marrow hematopoiesis and central nervous system functions, as well as to elderly patients. The appearance of ataxia, dizziness and any other deterioration neurological status patients require discontinuation of treatment.

With long-term therapy with metronidazole (more than 10 days), the picture should be monitored peripheral blood and liver function.

With leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process.

The use of metronidazole should be avoided in patients with porphyria.

When treating trichomonas vaginitis in women and trichomonas urethritis in men, it is necessary to abstain from sexual activity. Simultaneous treatment of sexual partners is mandatory. After treatment for trichomoniasis, control tests should be carried out during three consecutive cycles before and after menstruation.

After treatment of giardiasis, if symptoms persist, 3 stool tests should be performed after 3-4 weeks at intervals of several days (in some successfully treated patients, lactose intolerance caused by infestation may persist for several weeks or months, resembling the symptoms of giardiasis).

Patients should refrain from drinking alcohol during therapy with metronidazole, as well as for at least 48 hours after completion of treatment, due to the possibility of developing disulfiram-like reactions: cramping abdominal pain, nausea, vomiting, headache, sudden flushing of blood. face.

During treatment with metronidazole, urine may become dark or red-brown in color due to the presence of water-soluble dyes.

Trichopolum can cause immobilization of treponemes, which leads to a false-positive Nelson test.

Use in pediatrics

Impact on the ability to drive vehicles and operate machinery

Potentially, when taking this drug, avoid dangerous species activities requiring increased concentration of attention, speed of psychomotor reactions, especially driving vehicles and maintenance of mechanisms.

Drug interactions

Metronidazole enhances the effect of warfarin and other coumarin anticoagulants (with this combination, a reduction in the doses of both drugs is required).

Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the blood plasma and an increased risk of developing adverse reactions.

The simultaneous administration of drugs that stimulate the activity of microsomal liver enzymes (phenobarbital, phenytoin) can accelerate the elimination of metronidazole, which leads to a decrease in its concentration in the blood plasma.

In patients receiving long-term treatment with lithium drugs in high doses, when taking Trichopolum, it is possible to increase the concentration of lithium in the blood plasma and develop symptoms of intoxication.

When taking Trichopolum and cyclosporine in combination, an increase in the concentration of cyclosporine in the blood plasma may be observed.

Metronidazole reduces the clearance of fluorouracil, which may increase the toxicity of the latter.

When used concomitantly, metronidazole may increase plasma concentrations of bisulfan.

Sulfonamides enhance antimicrobial effect metronidazole.

Similarly to disulfiram, Trichopolum causes ethanol (alcohol) intolerance. The simultaneous use of Trichopolum with disulfiram can lead to the development of various neurological symptoms(the interval between the use of these drugs should be at least 2 weeks).

Analogues of the drug Trichopolum

Structural analogues according to active substance:

  • Bacimex;
  • Deflamon;
  • Klion;
  • Metrovagin;
  • Metrogil;
  • Metroxan;
  • Metrolacare;
  • Metron;
  • Metronidazole;
  • Metronidazole Nycomed;
  • Metronidazole-AKOS;
  • Metronidazole-Altpharm;
  • Metronidazole-UBF;
  • Metronidazole-ESCOM;
  • Metronidal;
  • Metroseptol;
  • Orvagil;
  • Rosamet;
  • Rosex;
  • Cyptrogyl;
  • Trichobrol;
  • Trichosept;
  • Flagyl;
  • Efloran.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

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Infection with protozoan microorganisms threatens a person, even with 100% indoor hygiene and personal care. It is impossible to predict that there will be no Giardia eggs in fish or meat. A helminthic infestation awaits people in minibuses, subways and shops. Therefore, infectious disease specialists recommend prophylaxis every six months. For this purpose, there are a number of drugs that can destroy all types of worm infestations. One of these is Trichopolum and its analogues.

About the drug

The dosage form Trichopolum and analogues are intended for treatment and complete freedom from the simplest microbes:

  • gardnerell;
  • Trichomonas;
  • Giardia;
  • anaerobic bacterial infections.

Untimely treatment or incorrectly selected medication (tablets, suspensions, folk recipes, suppositories) leads to disruption of the body as a whole. It also leads to the appearance of neuroses, decreased performance, chronic diseases. The most unpleasant thing is pungent odor from the oral cavity. This is the first sign of infection, even if no other signs are clearly observed.

The drug Trichopolum is produced in pharmacies in two versions. The first form of release is tablets. Reception - orally. The main actions of Trichopolum are designed to penetrate into digestive tract and absorption into tissues, organs, systems, biological fluids and blood. The process will take up to 2 hours. Only after 6-8 hours will the medication begin to be excreted independently by the body (urine and feces).

The second form of release is vaginal tablets. Trichopolum has been used in gynecology for a long time and successfully to combat microorganisms in genitourinary system. The distribution of the drug Trichopolum occurs exclusively in the tissues of the genital organs, without affecting other systems.

Prohibitions and adverse reactions

When prescribing Trichopolum to patients, the specialist must know the full clinical picture and take into account all the nuances in which the dosage form cannot be used. Studies have shown that the aerobic substance is well tolerated. But side reactions are possible. There are also a number of prohibitions:

Need to know! If you are allergic to the components of the drug Trichopolum, analogues are selected cheaper and without the presence of ingredients in the composition, such as in the original form. Only a doctor can tell what can be replaced and what analogues of Trichopolum will be safe.

Possibility of replacement

It is not so difficult to find an analogue of Trichopolum. Today, there are more than a dozen drugs that can become a cheap substitute according to indication and method of use. Divided into two types:

  • domestic origin. Any Russian analogue Trichopolum is cheap in cost, but is not inferior in quality;
  • foreign manufacturers. This option Trichopolum analogues are more expensive than Russian ones.

Metronidazole

The first and most common domestic substitute for Trichopolum is Metronidazole. The analogue of Trichopolum has two forms of release: tablets and solution for injection. For independent use tablets are prescribed; in a hospital setting, an injection solution is prescribed. Drug interactions of the analogue: complete duplication of the original product "Trichopol". Concomitant administration with other antimicrobials dosage forms prohibited. Selection of drugs that can strengthen immune system and restore the body’s microflora strictly as prescribed by the doctor. Contraindications and adverse reactions are identical to Trichopolum.

The analogue is used not only as therapy for helminthic infestations. Treatment may be prescribed if necessary:

  • alcoholism;
  • gastritis and duodenal ulcers;
  • infections reproductive system, abscesses, skin diseases;
  • trichomoniasis, leishmaniasis, trichomonas urethritis or vaginitis;
  • infectious diseases of the central nervous system, bone and joint tissue.

Tinidazole

The Trichopolum analogue has antifungal, antiprotozoal and antibacterial effects. It is recommended to buy in cases where there is an allergy to metronidazole. The main component is tinizol. The analogue copes well with giardiasis and anaerobic bacteria, diseases of infectious origin and affecting the development or worsening ulcerative lesions in the gastrointestinal tract, like Trichopolum.

The analogue is approved for use in children, but there are taboos during pregnancy and lactation. The standard dosage for a child is from 50 to 75 mg. Age and weight are taken into account. Children over 12 years of age are prescribed an analogue of Trichopolum, as are adults in the presence of anaerobic infection.

Flagyl

The drug and analogue of Trichopolum has two forms of release: tablets for oral administration and vaginal suppositories. Active ingredient Metronidazole. Trichopolum analogue actively affects most pathogenic microorganisms with their complete elimination. In addition to protozoal infections, it is used to treat sepsis, empyema, meningitis, and pneumonia.

To the adverse reactions of this analogue of Trichopolum is added

  • urinary incontinence
  • metallic taste
  • candidiasis
  • loss of appetite
  • dry mucous membranes
  • cystitis
  • When taking Flagyl, the urine becomes reddish-brown.

It should not be taken by people working with machinery, because:

  • the medicine can cause seizures,
  • weakness or increased excitability.

The course of treatment for each disease is different, usually no more than 7 days.

Klion

The actions and interactions of the Trichopolum analogue - Klion with other drugs are more accessible and extensively described in the instructions for use. High degree penetration and achievement of bactericidal concentrations in all organs and tissues of the body. The analogue is excreted by the kidneys 6-8 hours after administration.

By pharmacological properties similar to Metronidazole, and therefore Trichopolum. But the analogue is also prescribed for use by people who need to undergo radiation therapy. Since it is possible in 90% of cases to increase radiosensitization (cases of tumor resistance due to hypoxia in cellular composition growth).

Use of Trichopo analogue
La is allowed not only for adults, but also for children aged 2 years and older. The standard course of treatment is from 5 to 14 days, depending on the diagnosis and degree of the disease. Reviews left about the drug show that the presence of adverse reactions in the Trichopolum analogue is minimal (up to 3%). But you shouldn’t take it on your own. Exclusively as prescribed by a specialist.