Yox is a broad-spectrum antiseptic antimicrobial drug. Yox Spray: instructions, description PharmPrice

Each 30 ml bottle contains: povidone-iodine 2.55 g, allantoin 0.03 g;

excipients: levomenthol, citric acid monohydrate, sodium dihydrogen citrate, ethanol 96%, propylene glycol, purified water.

Description

Transparent, slightly opalescent liquid of red-brown color, indefinitely miscible with water.

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Pharmacological action

Indications for use

Disinfection of the oral cavity and pharynx for inflammatory and infectious diseases- tonsillitis, pharyngitis, tonsillitis-pharyngitis, tonsillitis, glossitis, aphthae; when preparing a patient for surgery and postoperative period; for the treatment of oral infections arising during chemotherapy, as an additional agent to antibiotic therapy for sore throats caused by streptococci, in influenza conditions in the prodromal period.

Contraindications

The drug is contraindicated in hypersensitivity to iodine or other components of the drug, with hyperfunction thyroid gland, with decompensated heart failure, with renal failure, it is contraindicated to use the drug 2 weeks before and after studies or radioactive iodine therapy.

The active substance penetrates the placental barrier and enters mother's milk, therefore the drug is contraindicated during pregnancy and lactation.

Yox spray is contraindicated in children under 8 years of age.

Pregnancy and lactation

Pregnancy

Experience local application There is no povidone-iodine in the oral cavity of pregnant women. At vaginal use povidone-iodine, or when applied topically to the skin during pregnancy or childbirth, congenital hyperthyroidism or struma has been detected in newborns, therefore the use of Yox during pregnancy is not recommended.

Lactation

Iodine passes into mother's milk. It was found several times in the blood and urine of newborns more iodine than their mothers who used povidone-iodine. High concentration in serum can cause hypothyroidism in newborns. For this reason, Yox is contraindicated for use during lactation.

Directions for use and doses

Adults and children over 8 years of age:

Usually applied 2-4 times a day, if necessary, more often (every 4 hours): 1-3 injections into the right and left side oral cavity or directly to the affected area. The interval between individual applications of the drug should be at least 4 hours. The drug can be used a maximum of 6 times per day. The dose of the drug is determined by the attending physician. Do not inhale or swallow the sprayed solution!

Remove the protective cap and install the applicator. Press the applicator 2-3 times so that the solution enters the sprayer and sprays after pressing. After this, place the applicator tube 2-3 cm into the oral cavity, hold your breath and press the cap twice so that one irrigation is carried out to the right, and the second to the left. The applicator is washed with hot water before and after use.

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Side effect

The drug is well tolerated.

IN in some cases hypersensitivity reactions to the drug are observed, possibly local manifestation allergic reaction on iodine (itching, hyperemia, urticaria), which requires discontinuation of the drug. Rarely, mainly in children, a short-term burning sensation or a feeling of dryness in the mouth appeared at the application site.

Overdose

There is no experience of overdose with proper local use in the mouth or pharynx.

When using iodine solution orally, it is possible acute poisoning iodine

Symptoms: At first, patients notice a metallic taste in the mouth, vomiting, pain in the stomach and stool disorders. Within 1 - 2 days, anuria, swelling of the glottis leading to asphyxia, aspiration pneumonia or pulmonary edema manifests itself. In some cases, vascular insufficiency was observed.

Treatment is purely symptomatic; first, standard measures are taken to stop absorption from gastrointestinal tract. The victim is given milk and boiled starch. If the esophagus is not affected, then gastric lavage can be performed. Then he is appointed activated carbon and 1% or 5% sodium thiosulfate solution, which reduces iodine to iodide. The elimination of absorbed substances can be accelerated by osmotic diuresis. Experience with dialysis similar situations not described in the literature.

Interaction with other drugs

It is not advisable to use the preparation fn Yox simultaneously with other antiseptics, intended for local O use in the mouth and throat, especially those containing hydrogen peroxide.

The use of Iox leads to false-positive results of stool analysis for occult blood. When studying the function of the thyroid gland, the amount of protein-bound iodine may increase.

Features of application

For laryngitis, the drug can be used only if absolutely necessary.

To quickly cure cough, bronchitis, pneumonia and strengthen the immune system, you just need...

Yox - a widespread combination medicine, and Yox spray instructions for use contain instructions that this is a throat preparation with iodine, which has an antiseptic effect and has a pronounced antibactericidal and antimicrobial effect.

Yox is used for diseases of the mouth and throat, as well as in ENT practice. Produced in the form of a spray and solution.

Spray composition

The spray is based on a povidone-iodine complex.

Substance povidone- this is a sorbent, thanks to which the gradual release of active iodine occurs.

Second active ingredient drug - allantoin (contains 0.03 grams). It has anti-inflammatory, antiseptic and regeneration-stimulating effects.

Additional substances in Yox spray:

• Levomenthol;
• Ethanol (about 25% volume);
• Citric acid, its sodium salt;
• Binding component;
• Water.

The spray has the smell of alcohol and menthol, characteristic brown, taste of iodine.

Yox spray is available in glass and plastic bottles of 30 milliliters.

Yox is not an aerosol: the product does not contain a propellant. Spraying is done by pressing a mechanical sprayer.

Indications for use of the spray

The effectiveness of the drug is determined by the bactericidal properties inherent in iodine:

1. When Yox comes into contact with the mucous membranes of the mouth or throat, iodine is released from the povidone-iodine compound.
2. By interacting with microbial proteins, iodine causes them to coagulate, which leads to the death of microorganisms.
3. The substance destroys bacteria, fungi, viruses, and protozoa.
4. Microorganisms that cause respiratory infections, are not able to form resistance to the substance.

Other active substance Yoxa - allantoin - stimulates restoration processes, ending up in the mucous membrane.

According to the instructions for use, Yox is indicated for:

• Sore throat (in combination with other medications);
• Pharyngitis;
• Infectious processes that affect the oral mucosa;
• In the postoperative period;
• For preoperative treatment.

Due to its irritating effect, the product effectively eliminates sore throat.

The instructions for use contain instructions that the drug can also be used in the treatment of superinfections that occur during therapy with antibiotics, antitumor, antiviral, and antifungal drugs.

Contraindications for use and precautions

Yox spray should not be used for the following contraindications:

• Pregnancy and breastfeeding;
• Hypersensitivity to the components of the drug;
• Increased thyroid function;
• Heart failure;
• Children under 6 years old;
• Herpes form of dermatitis.

In case of laryngitis, only a doctor can prescribe the remedy.

The medication should be used very carefully in patients with renal failure.

When irrigating and rinsing, it is better not to swallow Yox.

Avoid contact of the spray with mucous membranes, and if the product gets into your eyes, rinse them thoroughly with cold water.

Yox tends to stain the mucous membranes of the mouth and teeth, and stains can be removed with ethanol.

How to use the product?

Spray application:

1. If the bottle with Yox has a removable applicator, you should remove it from the packaging and then put it on the sprayer, having previously removed the protective cap.
2. Press several times until the iodine preparation begins to spray.
3. Caution should be exercised: if the drug gets on clothing, it leaves permanent marks.
4. When using, you need to hold the bottle only vertically.
5. Insert the applicator tube shallowly into your mouth and point it to the left.
6. Hold your breath.
7. Press the spray applicator once.
8. Send to right side spray tube.
9. Click once.
10. Remove the applicator after completing the procedure and rinse with warm water.
11. If a non-removable spray device is installed on the Yox bottle, steps 2-9 should be followed.

The spray can be sprayed as needed 2-5 times a day.

Instructions for children

Such measures are based on objective grounds:

• The drug contains alcohol;
• When spraying, you need to hold your breath;
• Yox spray has an increased ability to irritate the mucous membrane of the throat.

However, the product has a significant advantage that makes it preferable to other antiseptics: Yox spray does not contain antibiotics or synthetic antimicrobials.

Iodine is a natural antiseptic and, in addition, takes part in metabolic processes.

Thus, there is no harm from Yox - provided that the child does not have hyperthyroidism.

Pregnancy and lactation

According to the instructions for use, Yox cannot be used during pregnancy and lactation. There have been no studies on the effect of the drug on children, but two components - alcohol and iodine - are absorbed from the mucous membrane.

The amounts of these substances in a spray dose are microscopic. However, the same iodine, for example, is a highly active substance, daily requirement which even in pregnant women does not exceed 0.2 milligrams. A whole bottle contains about 14 milligrams of iodine.

Despite the ban on the use of the product, doctors prescribe it during pregnancy:

1) Firstly, the substance iodine is deposited in the body: about 10 milligrams are stored in the thyroid gland, another about 5-7 milligrams are stored in other organs. The absorption of the substance from the drug is insignificant: such an amount cannot affect the balance of iodine in the body. Oversaturation of the body with iodine occurs as a result of prolonged and systematic use of drugs or foods rich in iodine.

In this case, oversaturation expresses itself with obvious signs:

• The appearance of a metallic taste,
• Edema,
• Increased salivation
• Allergic manifestations.

The use of Yox cannot lead to overdose.

2) Iodine is still necessary for a pregnant woman. In areas where consumption of seafood rich in this element is low, iodine intake is required for the health of the unborn child and pregnant woman.

3) Thirdly, Yox spray based on iodine is an extremely effective drug.

Taken together, the above factors indicate that the benefits of using the drug outweigh the possible negative consequences.

The restriction on use for lactating women is explained by the fact that the mammary gland is also involved in storing iodine. Thus, nature provided for the substance to be supplied to the child through mother’s milk.

Video

Interaction with other drugs

Yox is not allowed to be used in parallel with radioactive iodine.

Side effects

Yox is usually very well tolerated, but among adverse reactions can diagnose allergies, manifested by hyperemia and itching. With prolonged use, excessive salivation, development of throat swelling, xerostomia, and a metallic taste are possible.

Analogs of Yox spray

The medicine does not have exact analogues containing povidone-iodine and allantoin.

2 available in pharmacies medicines based on iodine (release form - solution and spray), which can be used for respiratory diseases:

Iodinol

Lugol exists in Lithuanian and Russian versions. Iodinol - drug Russian production. Active ingredient in both cases iodine appears.

In Lugol, the substance is mixed with glycerol, which gives the drug an enveloping effect. Iodinol is a water-alcohol solution of iodine.

Which is better - Yox or Lugol?

Two fundamental differences should be highlighted:

• Lugol - aqueous solution with glycerol;
• Yox is an aqueous-alcoholic solution of the povidone-iodine complex.

These differences allow us to make the following comments about the benefits of these drugs.

Benefits of Yox:

• The presence of iodine in combination with povidone promotes a longer antimicrobial effect;
• Alcohol solutions are considered more effective antiseptics than water solutions.

Lugol's advantages:

• The absence of alcohol in the composition makes the spray more appropriate for use in children;
• The substance glycerol makes the product viscous, the liquid envelops and remains on the mucous membrane for a long time.

In addition, Lugol has a more affordable price.

However, consumers who have used both drugs prefer Yox.

YOX ®

Trade name

International nonproprietary name

Dosage form

Topical spray 30 ml complete with applicator

Compound

1 ml of solution contains

active substances: povidone iodine 85 mg, allantoin 1 mg,

excipients: levomenthol, monohydrate citric acid, sodium dihydrogen citrate, ethanol 96%, propylene glycol, purified water.

Description

Transparent liquid of red-brown color, slight opalescence is possible.

Farmacotherapy group

Preparations for the treatment of throat diseases. Antiseptics.

ATC code R 02 AA

Pharmacological properties

Pharmacokinetics

When polyvidone-iodine is applied topically to intact skin and mucous membranes, iodine absorption is minimal. Iodine in the body is converted into iodides, which accumulate mainly in thyroid gland. Iodides that are not captured by the thyroid gland are excreted mainly in the urine, a small amount is excreted in feces, saliva, and sweat. They pass through the placental barrier and enter breast milk.

Armacodynamics

Povidone-iodine, upon contact with the skin and mucosal membranes, releases organic iodine,which has a wide spectrum antimicrobial action regarding bacteria, fungi, viruses, protozoa.The drug also contains allantoin, which has an anti-inflammatory effect.

The antimicrobial effect of iodine is the result of its direct effect on proteins of microorganisms.

Indications for use

Sore throats, pharyngitis, tonsilopharengitis, tonsillitis, glossitis, aphthous stomatitis

When preparing a patient for surgical intervention and in the postoperative period on the respiratory tract and oral cavity

For the treatment of oral infections caused by chemotherapy,

In streptococcal sore throats it is used as additional treatment when treated with antibiotics

Directions for use and doses

Adults and children over 8 years old.

Remove the protective cap and install the applicator. Press the applicator 2 - 3 times so that the solution enters the sprayer and sprays after pressing. After this, place the applicator tube 2-3 cm into the oral cavity, hold your breath and press the cap 1-3 times so that one irrigation is carried out to the right, and the second to the left. It is recommended to use YOX spray 2-4 times a day, one injection to the right and left of the mouth and pharynx. The interval between individual applications of the drug should be at least 4 hours. If necessary, the drug can be used more often. Do not inhale or swallow the sprayed product!

The drug can be used a maximum of 6 times per day.

The applicator is rinsed with hot water before and after use.

Side effects

Allergic reaction to iodine (itching, hyperemia, urticaria)

Rarely: a burning sensation or a feeling of dryness in the mouth at the application site

The phenomenon of iodism (long-term use): metallic taste, increased salivation, swelling of the eyes or larynx, etc.

Contraindications

Hypersensitivity to iodine or other components of the drug

Hyperfunction of the thyroid gland

Decompensated heart failure

Pregnancy and breastfeeding

Children's age up to 8 years

Simultaneous use radioactive iodine

Dühring's dermatitis herpetiformis.

Drug interactions

It is not advisable to simultaneously use the drug Yox with other antiseptics intended for topical use in the oral cavity and pharynx.

Special instructions

For laryngitis, use the drug only in case of urgent need. The drug is used with caution in patients with liver failure.

The drug contains 18.6% ethanol.

Features of the use of the drug on the ability to drive vehicles or potentially dangerous mechanisms

Use the drug with caution due to the presence of ethyl alcohol in the composition.

Overdose

Symptoms:metallic taste in the mouth, vomiting, stomach pain and diarrhea. Within 1 - 2 days, anuria, edema of the glottis may occur, leading to asphyxia, aspiration pneumonia or pulmonary edema. In some cases, vascular insufficiency may develop.

Treatment: carry out symptomatic therapy. There is no specific antidote.

Release form and packaging

30 ml of the drug in a plastic bottle equipped with a mechanical sprayer and a protective cap. Each bottle, along with an applicator and instructions for use in the state and Russian languages, is placed in a cardboard box.

Storage conditions

Store in a place protected from light at a temperature of 10 0 C to 25 0 C. Keep out of the reach of children!

Shelf life

4 years

Do not use the drug after the expiration date indicated on the package.

Vacation conditions

Over the counter

Manufacturer

Registration Certificate Holder

Teva Czech Enterprises.r.o., Ostravska29, 74779 Opava-Komarov, Czech Republic.

Address of the organization that accepts claims from consumers regarding the quality of products (goods) on the territory of the Republic of Kazakhstan

Representative office of the company

« Teva Czech Industries sro. » vRK

050000 Republic of Kazakhstan

Almaty, Al-Farabi Avenue 13,

Trade name of the drug: JOX ®

International generic name or group name:
Povidone-iodine + Allantoin&

Dosage form:

topical spray

Compound

Active substances:
Povidone-iodine 2.550 g and allantoin 0.030 g per 30 ml.

Excipients:
levomenthol, citric acid monohydrate, sodium citrate dihydrate, ethanol 96%, propylene glycol, purified water.

Description
Transparent or slightly opalescent liquid of red-brown color, indefinitely miscible with water.

Pharmacotherapeutic group:

antiseptic

ATX code: A01AD; R02AA15

Pharmacological properties
Combined preparation for topical use for diseases of the oral cavity and ENT organs. Upon contact with skin or mucous membranes, it releases iodine; has an antiseptic and anti-inflammatory effect.
The drug has a wide spectrum of antimicrobial action.
Active against bacteria, fungi, viruses, protozoa.

Indications for use
1. Infectious and inflammatory diseases of the oral cavity and pharynx: including tonsillitis, tonsillitis, tonsillopharyngitis, glossitis, stomatitis, aphthae;
2. For treating the oral cavity and pharynx during surgical interventions on respiratory tract and oral cavity and in the postoperative period;
3. For the treatment of infections of the mouth and throat that occur during chemotherapy;
4. For streptococcal sore throats, it is used as additional remedy when treated with antibiotics.

Contraindications.
- hypersensitivity to iodine and other components of the drug;
- pregnancy and lactation;
- children under 8 years old;
- dysfunction of the thyroid gland (hyperthyroidism);
- heart failure;
- dermatitis herpetiformis Dühring;
- simultaneous use of radioactive iodine.

Directions for use and doses
Locally.
Remove the protective cap and install the applicator. Press the applicator 2-3 times so that the solution enters the sprayer and sprays after pressing. After this, place the applicator tube 2 - 3 cm into the oral cavity, hold your breath and press the cap twice so that one irrigation is carried out to the right, and the second to the left. It is recommended to use Yox ® spray 2-4 times a day. If necessary, the drug can be used more often, every 4 hours. The applicator is washed with hot water before and after use.

Side effect
Yox ® spray is usually well tolerated.
In some cases, hypersensitivity reactions to the drug and an allergic reaction to iodine (itching, hyperemia) are possible, which requires discontinuation of the drug. Long-term use of the drug can cause the phenomenon of iodism (including: metallic taste, increased salivation, swelling of the eyes or larynx), if this occurs, you should stop using the drug and consult a doctor.

Interaction with other drugs
The simultaneous use of Yox ® with other antiseptics intended for topical use in the oral cavity is not recommended. and throats, especially those containing hydrogen peroxide, due to inactivation of the drug.

Special instructions
Not intended for oral administration.
The drug should not be inhaled or swallowed.

Release form
Spray for topical use.
30 ml in bottles made of PE (polyethylene) or PET (polyethylene terephthalate), equipped with a mechanical sprayer and a lid to protect the sprayer. Each bottle, complete with an applicator or an applicator with a rotary lever, is placed in a cardboard box with instructions for use.

Storage conditions
At temperatures from 10 °C to 25 °C in a place protected from light. Keep out of the reach of children.

Best before date
4 years.
Do not use after the expiration date indicated on the package!

Vacation conditions
Over the counter.

Manufacturer
Ivax Pharmaceuticals s.r.o., Czech Republic Ostravska 29, 74770 Opava-Komarov
IVAX Pharmaceuticals s.r.o., Ostravska 29, 74770 Opava-Komarov, Czech Republic

Address for receiving complaints.
119049, Moscow, st. Shabolovka, 10, building 2, Business center "Concord"

P NO 14300/01

Trade name of the drug: JOX ®

International nonproprietary name or generic name:
Povidone-iodine + Allantoin&

Dosage form:

topical solution

Compound:

Active substances:
Povidone-iodine 4.250 g and allantoin 0.050 g in 50 ml of solution. Povidone-iodine 8.500 g and allantoin 0.100 g in 100 ml of solution.

Excipients:
levomenthol, citric acid monohydrate, sodium citrate dihydrate, ethanol 96%, propylene glycol, purified water - up to the required volume of the drug in the package.

Description
Transparent or slightly opalescent liquid of red-brown color, indefinitely miscible with water.

Pharmacotherapeutic group:

antiseptic

ATX code: A01AD; R02AA15

Pharmacological properties

Combined preparation for local use for diseases of the oral cavity and ENT organs. Upon contact with skin or mucous membranes, it releases iodine; has an antiseptic and anti-inflammatory effect.
The drug has a wide spectrum of antimicrobial action.
Active against bacteria, fungi, viruses, protozoa.

Indications for use
1. Infectious and inflammatory diseases of the oral cavity and pharynx: including tonsillitis, tonsillitis, tonsillopharyngitis, glossitis, stomatitis, aphthae;
2. For treatment of the oral cavity and pharynx during surgical interventions on the respiratory tract and oral cavity and in the postoperative period;
3. For the treatment of infections of the mouth and throat that occur during chemotherapy;
4. For streptococcal sore throats, it is used as an additional remedy in antibiotic treatment.

Contraindications.

hypersensitivity to iodine and other components of the drug;

pregnancy and lactation;

children under 6 years old;

dysfunction of the thyroid gland (hyperthyroidism);

heart failure; Dühring's dermatitis herpetiformis;

simultaneous use of radioactive iodine. Directions for use and doses Locally.
Dilute the drug solution with water in a ratio of 1:20 - 1:40 (i.e. from 2.5 ml to 5 ml using the measuring cap included in the package or 1/2 - 1 teaspoon in 100 ml of water). Rinse the mouth or throat with a diluted solution.
It is recommended to use the drug Yox ® solution 2-4 times a day; if necessary, the drug can be used more often up to 6 times a day. Minimum intervals between rinses are 4 hours. Side effect
Yox ® solution is usually well tolerated.
In some cases, hypersensitivity reactions to the drug and an allergic reaction to iodine (itching, hyperemia) are possible, which requires discontinuation of the drug.
Long-term use The drug may cause the phenomenon of iodism (including a metallic taste, increased salivation, swelling of the eyes or larynx), if this occurs, you should stop using the drug and consult a doctor. Interaction with other drugs
The simultaneous use of Yox ® with other antiseptics intended for local use in the oral cavity and pharynx, especially those containing hydrogen peroxide, is not recommended due to inactivation of the drug. Special instructions
Not intended for oral administration.
The drug should not be inhaled or swallowed.
The drug contains about 19% ethanol. Release form
Solution for topical use.
50 and 100 ml in dark glass bottles with a screw-on propylene cap with tamper evident and a measuring cap. Each bottle, along with instructions for use, is placed in a cardboard box. Storage conditions
At temperatures from 10 °C to 25 °C in a place protected from light. Keep out of the reach of children. Best before date
5 years.
Do not use after the expiration date indicated on the package! Vacation conditions
Over the counter. Manufacturer
Ivax Pharmaceuticals s.r.o., Czech Republic
Ostravska 29, 74770 Opava-Komarov
IVAX Pharmaceuticals s.r.o., Ostravska 29, 74770 Opava-Komarov, Czech Republic Address for receiving complaints. 119049, Moscow, st. Shabolovka, 10, building 2, Business center "Concord"