Anti-inflammatory and antiseptic - children's Panadol syrup: instructions for use for various diseases. Panadol syrup: instructions for use for children

Pharmacological action:
Panadol Baby- a medicinal product for use in pediatrics with antipyretic and analgesic effects. The drug contains active substance- paracetamol is a drug from the group of non-selective non-steroidal anti-inflammatory drugs. The mechanism of action of the drug is based on its ability to inhibit the enzyme cyclooxygenase, as a result of which the synthesis of prostaglandins is inhibited. Reducing the amount of prostaglandins in the central nervous system helps eliminate pain, and the direct effect of the drug on the thermoregulation center helps reduce elevated body temperature. The anti-inflammatory effect of the drug is insignificant, since paracetamol is inactivated by cellular peroxidases.
After oral administration the drug is well absorbed into digestive tract, the maximum plasma concentration of paracetamol is observed 15-60 minutes after oral administration. Metabolized in the liver, excreted in the urine in the form of metabolites. The half-life is from 1 to 4 hours.

Indications for use:
Preparation Panadol Baby used to relieve pain various localizations, including toothache and teething pain.
In addition, the drug is used to reduce elevated body temperature in childhood infections (including chicken pox, whooping cough, measles, mumps), ARVI and influenza. The drug can be used to treat post-vaccination hyperthermia in children.

Directions for use

Suspension for oral use containing 120 mg of active substance per 5 ml:
The drug is taken orally; it is recommended to dose the suspension using a special dosing device; it is not recommended to dissolve the suspension in water or tea, however, after administration, the suspension can be washed down with water or tea. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.
The recommended single dose of the drug is 10-15 mg/kg body weight, the daily dose is 60 mg/kg body weight. The interval between doses of the drug should be at least 4 hours. If you need to use the drug for more than 3 days in a row, you must contact your doctor.
For the treatment of post-vaccination hyperthermia, children aged 2-3 months are usually prescribed 2.5 ml of suspension. If necessary, a repeat dose of the drug is prescribed, but not earlier than 4 hours after the previous dose. If your body temperature has not returned to normal, you should consult your doctor.

Children aged 3 to 6 months are usually prescribed 4 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 6 months to 1 year are usually prescribed 5 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 1 to 2 years are usually prescribed 7 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 2 to 3 years are usually prescribed 9 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 3 to 6 years are usually prescribed 10 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 6 to 9 years are usually prescribed 14 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Children aged 9 to 12 years are usually prescribed 20 ml of the drug 3-4 times a day with an interval of at least 4 hours.
Suppositories containing 125 mg of active substance:
The drug is administered rectally. To achieve maximum therapeutic effect It is recommended to use the drug after defecation. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.
Children aged 3 months to 3 years are usually prescribed 1 suppository 3 times a day with an interval of at least 4 hours. If you need to use the drug for more than 3 days in a row, you should consult your doctor.

Side effects

Preparation Panadol Baby is usually well tolerated by patients, but in some cases the development of such side effects:
From the outside gastrointestinal tract and liver: nausea, vomiting, pain in the epigastric region, increased activity of liver enzymes, liver dysfunction. In addition, some laxative effects of the drug are possible.
From the hematopoietic system: anemia, including hemolytic anemia, sulfhemoglobinemia and methemoglobinemia.
Allergic reactions: skin rash, itching, urticaria, Stevens-Johnson syndrome, Lyell's syndrome, Quincke's edema, anaphylactic shock.
Others: bronchospasm (mainly in patients with hypersensitivity to nonsteroidal anti-inflammatory drugs), decreased blood sugar, including hypoglycemic coma.

Contraindications:
Increased individual sensitivity to the components of the drug.
Children's age is less than 2 months.
The drug is not prescribed to patients with congenital hyperbilirubinemia, glucose-6-phosphate dehydrogenase deficiency and blood diseases, including anemia and leukopenia.
The drug should not be used to treat patients suffering from pronounced violations liver and/or kidney functions.
The drug in the form of a suspension is contraindicated in patients with hereditary fructose intolerance.
The drug should be prescribed with caution to children aged 2-3 months who were born prematurely.

Interaction with other drugs

When used simultaneously, metoclopramide and domperidone increase the absorption of paracetamol.
When combined with cholestyramine, a decrease in the absorption of paracetamol is observed.
With regular combined use of the drug with coumarin anticoagulants, including warfarin, the risk of bleeding may increase.
When used simultaneously, barbiturates reduce the antipyretic effect of paracetamol.
Inducers of microsomal liver enzymes, isoniazid and drugs with hepatotoxic effects enhance the hepatotoxic effect of paracetamol.
When used simultaneously, the drug reduces the effectiveness of diuretics.
Paracetamol is not used simultaneously with ethyl alcohol.

Overdose

At long-term use high doses of the drug may develop disorders of the hematopoietic system, including thrombocytopenia, pancytopenia, neutropenia, leukopenia, agranulocytosis and aplastic anemia. In addition, when using excessive doses of the drug, the development of interstitial nephritis, papillary necrosis, pallor skin, loss of appetite, nausea, abdominal pain and liver disorders. In some cases, with an overdose of the drug, drowsiness was observed, psychomotor agitation, arrhythmias, limb tremors and seizures. In case of severe poisoning with the drug, disorders may develop carbohydrate metabolism and metabolic acidosis.
In case of overdose, gastric lavage, taking enterosorbents and symptomatic therapy. If less than 48 hours have passed since taking the drug, oral methionine is indicated and intravenous administration N-acetylcysteine. Overdose should be treated in a hospital setting.

Release form

Suspension of 100 ml in dark glass bottles, 1 bottle complete with a dosing device in a cardboard package.
Suppositories, 5 pieces in strips, 2 strips in a cardboard package.

Storage conditions:
It is recommended to store the drug in a dry place away from direct sun rays at a temperature not exceeding 25 degrees Celsius.
The shelf life of the drug in the form of a suspension for oral use is 3 years.
The shelf life of the drug in the form of suppositories is 5 years.

Synonyms

Paracetamol.

Compound

5ml oral suspension contains:
Paracetamol - 120 mg;
Excipients, including sorbitol.

1 suppository contains:
Paracetamol - 125 mg;
Excipients.

Basic parameters

Name:

PANADOL BABY

Each 5 ml of suspension contains: active ingredient - paracetamol 120 mg; inactive ingredients: malic acid, xanthan gum, glucose syrup hydrogenate (maltitol), sorbitol (E 420), citric acid anhydrous, sodium nipasept (sodium ethyl parahydroxybenzoate (E 215), sodium propyl parahydroxybenzoate (E 217), sodium methyl parahydroxybenzoate (E 219)), strawberry flavor (L10055), azorubine (E 122), water.

Description

Pink viscous liquid with a strawberry odor, containing crystals.

Pharmacological action

The drug has analgesic and antipyretic properties. Blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation. The anti-inflammatory effect is practically absent.

Pharmacokinetics

Absorption is high - paracetamol is quickly and almost completely absorbed from the gastrointestinal tract. Plasma protein binding is about 15%. Peak plasma concentrations are reached after 30-60 minutes.

The distribution of paracetamol in body fluids is relatively even. Metabolized primarily in the liver with the formation of several metabolites. In newborns in the first two days of life and in children 3-10 years of age, the main metabolite of paracetamol is paracetamol sulfate; in children 12 years of age and older, it is conjugated glucuronide. Part of the drug (approximately 17%) undergoes hydroxylation with

the formation of active metabolites that conjugate with glutathione. With a lack of glutathione, these metabolites of paracetamol can block the enzyme systems of hepatocytes and cause their necrosis.

The half-life of paracetamol when taking a therapeutic dose is 2-3 hours.

Upon admission therapeutic doses 90-100% of the dose taken is excreted in the urine within one day. The main amount of the drug is released after conjugation in the liver. No more than 3% of the received dose of paracetamol is excreted unchanged.

Indications for use

Used in children from 3 months to 12 years as:

Antipyretic - to reduce elevated body temperature against the background colds, influenza and childhood infectious diseases (chicken pox, mumps, measles, rubella, scarlet fever, etc.)

Anesthetic - for toothache, including teething, headaches, ear pain with otitis media and sore throat.

For children 2-3 months of age, a single dose is possible to reduce fever after vaccination. If the temperature does not decrease, consult a doctor.

Contraindications

Increased sensitivity to paracetamol or any other ingredient of the drug;

Severe liver or kidney dysfunction;

Hereditary fructose intolerance

Children under 2 months

Pregnancy and lactation

The drug is intended for children.

Directions for use and doses

The drug is taken orally.

The contents of the bottle should be shaken well before use. The measuring syringe placed inside the package allows you to dose the drug correctly and rationally.

The dose of the drug depends on the age and body weight of the child.

For children over 3 months of age, a single dose is 10-15 mg/kg body weight, 3-4 times a day, maximum daily dose is no more than 60 mg/kg body weight. If necessary, give your child the recommended dose every 4 to 6 hours, but no more than 4 doses in 24 hours.

In all other cases, before taking Panadol for Children, you should consult a doctor.

Duration of admission without consulting a doctor:

1. No more than 3 days.

Side effect

At recommended doses, paracetamol rarely has side effects. Sometimes nausea, vomiting, pain in the stomach, impaired liver function, allergic reactions(skin rash, itching, urticaria, Quincke's edema, syndrome Stevens-Johnson), bronchospasm in patients sensitive to acetylsalicylic acid and other NSAIDs. Rarely - anemia, thrombocytopenia, leukopenia. Sodium methyl parahydroxybenzoate, ethyl parahydroxybenzoate and propyl parahydroxybenzoate may cause allergic reactions.

When adverse reactions Stop taking the drug immediately and consult your doctor.

Overdose

Signs acute poisoning paracetamol are nausea, vomiting, stomach pain, sweating, pale skin. After 1-2 days, signs of liver damage are determined (pain in the liver area, increased activity of liver enzymes). In severe cases it develops liver failure, encephalopathy and coma.

Taking paracetamol by an adult in a dose of 10 g or more can cause liver damage. When ingesting 5 g of paracetamol or more, liver damage may occur if the patient has the following risk factors:

The patient has been taking carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, St. John's wort or other drugs that induce liver enzymes for a long time.

The patient regularly abuses alcohol,

Patients at risk of glutathione deficiency (eating disorders, cystic fibrosis, HIV infections, starvation, exhaustion).

Symptoms of overdose in the first 24 hours after taking paracetamol: pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may appear within 12 to 48 hours after taking paracetamol. Disorders of glucose metabolism may develop and metabolic acidosis. In severe poisoning, progression of liver failure can lead to the development of encephalopathy, bleeding, hypoglycemia, cerebral edema and death. Acute renal failure, caused by acute tubular necrosis, is manifested by low back pain, hematuria, proteinuria and can develop even in the absence of serious liver damage. Violations are also possible heart rate and pancreatitis. Despite the lack of obvious early symptoms, patients should be rushed to the hospital for immediate medical attention. Symptoms may be limited to nausea or vomiting and may not reflect the severity of overdose or the risk of organ damage. In case of accidental overdose, seek medical advice immediately medical care, even if the child feels well.

Treatment: Stop using the drug and consult a doctor immediately. Gastric lavage is recommended. If less than 1 hour has passed since taking paracetamol, activated charcoal should be prescribed.

Plasma concentrations of paracetamol should be assessed 4 hours and later after dosing (earlier concentration determinations are unreliable). Up to 24 hours after taking paracetamol, N-acetylcysteine ​​can be prescribed, but the maximum healing effect achieved by administering N-acetylcysteine ​​up to 8 hours after taking paracetamol. If necessary, the patient should be given intravenous administration of N-acetylcysteine, in accordance with the established dosage regimen. If the patient can be induced to vomit, methionine may be a suitable alternative for outlying areas. Treatment of patients with serious violations liver function should be carried out in specialized departments.

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Interaction with other drugs

When using Panadol for Children together with barbiturates, diphenin, anticonvulsants, rifampicin, butadione, the risk of hepatotoxicity may increase.

At simultaneous administration with chloramphenicol (chloramphenicol), the toxicity of the latter may increase.

Instructions

Panadol syrup helps relieve fever in a child, relieve pain and inflammation caused by colds. Most parents respond positively to this medicine.

Compound

The analgesic is sold in the form of a suspension for oral administration with a pleasant strawberry aroma. 5 ml of the product contains 120 mg of paracetamol, acting active substance medicines. Additional composition:

• maltitol;
• xanthan gum;
• malic acid;
• sodium nipasept;
• strawberry flavor;
• water;
• azorubine;
• citric acid;
• sorbitol.

The suspension is placed in dark glass bottles of 100 or 300 ml. The medication comes with instructions and a measuring syringe.

Pharmacological group

Antipyretics-analgesics (anilides).

Mechanism of action

Pharmacodynamics

Antipyretic-analgesic has antipyretic and analgesic effects. Suppresses the activity of cyclooxygenase in the central nervous system, influencing the center of temperature regulation and pain.

It has almost no anti-inflammatory effect. The medication does not affect the mucous membranes of the esophagus and water-salt balance, as it does not change the production of prostaglandins.

Pharmacokinetics

The drug is different high degree absorption. Paracetamol is absorbed from the gastrointestinal tract. Its highest plasma level is observed after 30-60 minutes.

The level of binding to plasma proteins reaches 15%. Evenly distributed in biofluids.

Metabolism of paracetamol occurs in the liver structures.

The half-life is from 2 to 3 hours. Stands out drug along with urine.

Indications for use

Panadol Baby syrup is prescribed to children from 3 months to 12 years in the following cases:

• to reduce fever against the background of colds and infectious pathologies (measles, mumps, scarlet fever, chicken pox, rubella, Michigan influenza);
• for the purpose of preventing rickets;
• to eliminate toothache, ear and headache, as well as throat discomfort.

In patients 2-3 months of age, a single use of the suspension may be prescribed to reduce fever after vaccination.

Contraindications

The suspension is not indicated in the following situations:

• with individual sensitivity to paracetamol and other elements of the syrup;
• newborn children (due to the risk of pathologies of physical development);
• severe pathologies of the kidneys and liver.

The medicine is prescribed carefully when severe forms blood diseases, moderate violations kidney and liver function.

The medication must not be used in combination with other drugs that contain paracetamol.

How to take Panadol syrup?

How to calculate the dose?

Dosages are calculated taking into account the weight and age of the child. For infants 2-3 months old, the medicine is prescribed with caution and under the supervision of a specialist. Approximate dosages for children (by weight):

• 3-6 months, 6-8 kg: single - from 96 mg, daily - 384 mg;
• 6-12 months and weighing 8-10 kg: single dose - from 120 mg, maximum - 480 mg;
• from 1 year to 2 years and with a weight of 10-13 kg: single - 168 mg, maximum - 672 mg;
• 2-3 years and with a body weight of 13-15 kg: single dose - 216 mg, not more than 864 mg per day;
• from 3 to 6 years with a weight of 15-21 kg: one-time - 240 mg, maximum - 960 mg;
• 6-9 years old with a weight of 21-29 kg: single dose - 336 mg, maximum - 1344 mg;
• from 9 to 12 years old with a weight of 29-42 kg: single dose - 480, not more than 1920 mg per day.

Before or after eating?

It is advisable to take the medication before meals. In this case, its absorption level will be optimal.

How long does it take for the syrup to work?

The syrup begins to act within 30-60 minutes after oral administration.

Action time

The effect of the medicine lasts up to 4-5 hours.

How to give it to a child?

Children's syrup is taken orally. Before use, the bottle of medication should be shaken thoroughly. It is recommended to select dosages using a measuring syringe.

Side effects from taking Panadol syrup

A child may experience skin rashes while using the syrup, angioedema, urticaria, vomiting, abdominal discomfort, anemia, leukopenia and heart rhythm disturbances.

In this case, you should stop taking the medication and seek help from a medical specialist.

Overdose

Signs of paracetamol poisoning: abdominal pain, nausea and vomiting, pale skin, increased sweating. After 1-2 days, lesions of the liver structures may develop. IN difficult situations liver failure, coma and encephalopathy are observed.

At chronic overdose nephrotoxic and hepatotoxic manifestations may be observed (interstitial nephritis, bacteriuria, renal colic, papillary form of necrosis).

The child is indicated for intestinal lavage and the use of Polyphepan or activated carbon(enterosorbents). Acetylcysteine ​​is an effective antidote to paracetamol.

Features of using Panadol syrup

The doctor should be informed about taking the syrup when prescribing tests to determine the concentration of glucose and uric acid in blood serum.

Abdominal pain is one of the signs of paracetamol poisoning.

When using the medicine for a course longer than 7 days, it is advisable to control the composition peripheral blood and liver function.

Is syrup ok during pregnancy and lactation?

Syrup (suspension) is used in pediatrics. Pregnant and lactating women can take the drug only as prescribed by a doctor.

For impaired renal function

The syrup is prescribed with caution for moderate disorders. In severe cases, it should not be taken.

Effect on concentration

The syrup does not interfere with psychomotor function.

Drug interactions

With other drugs

When used simultaneously with an analgesic anticonvulsants, Diphenin, barbiturates, Butadione and Rifampicin increase the likelihood of a hepatotoxic effect.

In combination with Chloramphenicol, its toxicity increases.

The anticoagulant activity of Warfarin and other coumarin derivatives increases with prolonged use of paracetamol, which can cause bleeding.

Alcohol compatibility

It is prohibited to combine the drug with alcohol-containing medications and drinks.

Storage conditions and periods

The syrup should not be frozen. A place protected from the sun and moisture, at temperatures up to +30°C, is suitable for storing it. The shelf life of the syrup is 36 months.

Conditions for dispensing from pharmacies

Is it sold without a prescription?

The syrup is an over-the-counter medicine.

What is the price?

From 87 rub. per bottle of 100 ml.

Analogs

• Panadol suppositories;
• Paracetamol (syrup, tablets and suppositories for rectal administration);
• Efferalgan ( rectal suppositories and syrup);
• Cefekon.

Composition and release form

5 ml of oral suspension contains paracetamol 120 mg; in bottles equipped with a plastic measuring spoon and a special protective cap, 100 and 300 ml, 1 set in a box.

1 rectal suppository - 125 mg; in polymer film 5 pcs., in cardboard box 2 films.

Pharmacological action

Pharmacological action- analgesic, antipyretic.

Suppresses PG synthesis in the central nervous system, reduces the excitability of the thermoregulation center in the hypothalamus, and increases heat transfer.

Pharmacodynamics

It has analgesic and antipyretic properties, the latter manifesting itself in febrile syndrome of any origin.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract. Plasma concentrations reach peak after 30-60 minutes; T1/2 plasma - 1-4 hours after taking therapeutic doses. Evenly distributed in the body. Metabolized in the liver to form paracetamol esters with glucuronic and sulfuric acids. 90-100% of the drug is excreted in the urine during the first day in the form of metabolites.

Indications for the drug Children's Panadol

Pain and fever syndromes (colds, flu, children's infectious diseases, toothache, pain during teething, ear pain with otitis media, headache, sore throat).

Contraindications

Hypersensitivity.

Side effects

Erythematous and urticarial skin rash.

Interaction

T1/2 is prolonged by barbiturates and tricyclic antidepressants. The effect is reduced by anticonvulsants.

Directions for use and doses

Suspension: orally, children from 3 months to 1 year are prescribed 1/2-1 measuring spoon (5 ml), children from 1 year to 6 years - 1-2 measuring spoons (5-10 ml), from 6 to 12 years - 2 -4 measuring spoons (10-20 ml). If necessary, re-prescribe every 4 hours (but not more than 4 doses per day).

Suppositories: rectally, children from 3 months to 3 years - 1 supp. every 4-6 hours (but no more than 3 times a day).

Overdose

In the first 24 hours: pallor, nausea, vomiting, anorexia, pain in the abdominal area. After 12-48 hours: liver damage, metabolic disorders, metabolic acidosis. In severe poisoning, liver failure may progress (with the development of encephalopathy, coma and fatal outcome). Acute renal failure with acute tubular necrosis can develop in isolation (in the absence of severe liver damage). Other disorders include cardiac arrhythmias and pancreatitis. Drug therapy: methionine orally or intravenously N-acetylcysteine ​​(in the first 2 days after an overdose).

Precautions

Cannot be used with other paracetamol-containing products. Prescribe with caution to children with impaired liver and kidney function. Before use in premature babies and children under 3 months (when taken for more than 3 days in a row), you should consult a doctor for advice.

Special instructions

Clinical (and laboratory) manifestations of hepatotoxicity can be observed in a delayed period (up to 1 week).

Storage conditions for the drug Children's Panadol

At a temperature not exceeding 30 °C (do not freeze).

Keep out of the reach of children.

Shelf life of the drug Children's Panadol

rectal suppositories for children 125 mg - 5 years.

oral suspension 120 mg/5 ml - 3 years.

syrup for children 120 mg/5 ml - 3 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Category ICD-10	Synonyms of diseases according to ICD-10
H66 Purulent and unspecified otitis media	Bacterial ear infections
	Inflammation of the middle ear
	ENT infections
	Infectious and inflammatory disease of ENT organs
	Infectious and inflammatory diseases of the ENT organs
	Infectious and inflammatory diseases of the ear
	Infectious diseases of the ENT organs with severe pain syndrome
	Ear infection
	Infectious otitis media
	Persistent inflammation of the middle ear in children
	Ear pain due to otitis media
J03.9 Acute tonsillitis, unspecified (angina agranulocytic)	Angina
	Sore throat, alimentary-hemorrhagic
	Sore throat secondary
	Primary tonsillitis
	Sore throat follicular
	Sore throats
	Bacterial tonsillitis
	Inflammatory diseases of the tonsils
	Throat infections
	Catarrhal sore throat
	Lacunar tonsillitis
	Acute sore throat
	Acute tonsillitis
	Tonsillitis
	Acute tonsillitis
	Tonsillar tonsillitis
	Follicular tonsillitis
	Follicular tonsillitis
K13.7 Other and unspecified lesions of the oral mucosa	Aspirin burn of the oral mucosa
	Sore gums when wearing dentures
	Oral inflammation
	Inflammation of the oral mucosa
	Inflammation of the oral mucosa after radiation therapy
	Inflammation of the oral mucosa after chemotherapy
	Inflammation of the oral mucosa
	Inflammation of the mucous membranes of the oral cavity
	Inflammatory diseases of the oral cavity
	Inflammatory process of the pharynx
	Disease of the oral mucosa
	Radioepithelitis
	Irritation from dentures
	Irritation of the oral mucosa by dentures and braces
	Oral wounds
	Sores from wearing dentures
	Injuries to the oral cavity and larynx
	Injuries to the oral mucosa
	Trophic diseases of the oral mucosa
	Trophic diseases of the oral mucosa
	Erosive and ulcerative periodontal lesions
	Erosive and ulcerative lesions of the oral mucosa
	Erosive and ulcerative periodontal lesions
	Erosive and ulcerative lesions of the oral mucosa
	Erosion of the oral mucosa
R50 Fever of unknown origin	Hyperthermia malignant
	Malignant hyperthermia
R51 Headache	Head pain
	Pain due to sinusitis
	Pain in the back of the head
	Headache
	Headache of vasomotor origin
	Headache of vasomotor origin
	Headache with vasomotor disturbances
	Headaches
	Neurological headache
	Serial headache
	Cephalgia
R52.2 Other persistent pain	Pain syndrome of non-rheumatic origin
	Pain syndrome with vertebrogenic lesions
	Pain syndrome with neuralgia
	Pain syndrome from burns
	Pain syndrome is mild or moderate
	Neuropathic pain
	Neuropathic pain
	Perioperative pain
	Moderate to severe pain
	Moderate or mild pain syndrome
	Moderate to severe pain syndrome
	Ear pain due to otitis media

Medicines with antipyretic effects are certainly present in the medicine cabinet of families with small children, because elevated body temperature can be called one of the most common symptoms childhood diseases

Drugs are often used to combat fever in children. based on paracetamol, because they are called one of the safest in childhood. A representative of such medications is Children's Panadol. When is it prescribed to children, in what dosages is it prescribed, is it used in infants, and what analogues are replaced if necessary?

Release form

Children's Panadol, which is also called Panadol Baby, comes in two forms:

1. Suspension. This Panadol is a sweet-tasting syrup-like liquid (due to its viscous consistency, this medicine is often called syrup) with a strawberry aroma and a pink tint. The solution is bottled in glass bottles and sold in two volumes - 100 ml and 300 ml. The bottle comes with a plastic syringe that helps you accurately measure milliliters of suspension.
2. Rectal suppositories. They are sold in a box of 5 to 20 pieces, packed in strips of 5-10 suppositories. These candles have a uniform structure, cone shape and white color. Normally, a candle released from packaging should not have physical defects or any impurities.

Compound

The main ingredient in both forms of Panadol Baby is paracetamol. In the suspension it is contained in a dose of 120 mg / 5 ml, and in one suppository - in the amount of 125 mg or 250 mg.

The only additional component of suppositories is solid fat, and liquid Panadol contains a lot excipients, among which there is maltitol, flavoring, sorbitol, malic acid, azorubine and other compounds. However There is no sugar or alcohol in the suspension.

Operating principle

Paracetamol in Children's Panadol can affect cyclooxygenase. This enzyme, which is found in the cells of the central nervous system, is responsible for the formation of prostaglandins. Its inhibition interferes with the synthesis of such substances, as a result of which the medicine affects the centers of pain and thermoregulation. This leads to a gradual decrease in temperature and disappearance of pain.

Compared to others non-steroidal drugs with the same effects, Panadol has almost no anti-inflammatory effect. This medication does not affect the synthesis of prostaglandins, which occurs in peripheral tissues. This determines no harmful effects of the drug on the digestive tract.

Paracetamol from the suspension is absorbed faster than from suppositories. The effect of the liquid drug taken orally begins in approximately 15-20 minutes, and after administration of the suppository, the effect develops within 1.5-2 hours. The duration of action of both forms is about 4 hours.

Metabolic transformations of paracetamol take place in the liver, and approximately 90% of this substance leaves the body within 24 hours in the urine.

Indications

The most common reason for using Children's Panadol is elevated temperature bodies. The medicine is given:

• with the flu;
• with scarlet fever;
• with ARVI;
• for measles;
• with chicken pox;
• with intestinal infection;
• for mumps and other childhood infections;
• when a temperature reaction to the vaccine appears.

Since Panadol is still able to relieve pain, the suspension and suppositories are also used for pain syndrome. The drug is in demand for teething, pain in the ears caused by otitis media, pain due to bruises, pain in the throat due to sore throat and so on.

From what age is it used?

It is usually not prescribed to babies under 3 months of age, but the drug can be given to an infant for 1-3 months to reduce the temperature caused by vaccination. However, such a dose should be one-time and only under the supervision of a doctor. If after one dose the medication does not bring down the temperature, you cannot give the syrup again.

The suspension is strictly contraindicated for babies in the first month of life.. The issue of using the suspension in children older than 3 months who were born ahead of schedule, the doctor decides.

Teenagers over 12 years old liquid form also not prescribed, since Panadol tablets are 500 mg per adolescence more convenient.

Panadol suppositories are not used until six months of age. At the same time, suppositories containing 125 mg of the active ingredient are prescribed to children from 6 months to 2 and a half years, and a drug with more high dose paracetamol (250 mg per suppository) is used in patients aged 3 to 6 years.

There are also weight restrictions for the use of suppositories - a drug with 125 mg is prescribed for a body weight of 8 to 12.5 mg, and suppositories of 250 mg are given to children who weigh from 13 to 20 kg.

Panadol suppositories are not prescribed to patients over 6 years of age and weighing more than 20 kg.

Contraindications

Panadol Baby should not be taken by children:

• with intolerance to paracetamol or another component of the drug;
• with impaired kidney function;
• with a genetically determined absence of glucose 6-phosphate dehydrogenase in the body;
• with severe liver diseases;
• with anemia and other blood diseases.

The suspension is also contraindicated in case of fructose intolerance, and suppositories are not used in case of inflammation of the rectum or bleeding from this part of the intestine.

Adults when carrying a child or breastfeeding take Panadol not prohibited.

Side effects

Manufacturers warn about the following possible side effects:

• When treating Panadol Baby, allergic reactions may occur. In some children they manifest themselves as rashes, in others - itching or redness of the skin, but in in rare cases may develop Quincke's edema, urticaria or anaphylactic shock.
• The use of the drug may affect the number of blood cells. A decrease in their number sometimes occurs with prolonged use of Panadol.
• If a child has increased sensitivity to NSAID drugs, then taking Panadol may cause bronchospasm.
• Very rarely, the medication disrupts liver function or causes negative symptoms from the gastrointestinal tract.

Instructions for use

The drug is used in strict accordance with the instructions in the instructions:

• A single dose of Panadol in suppositories is 1 suppository, and the method of administration of such a medicine is rectal.
• The suppositories are inserted in a supine position (it is recommended that the child be on the left side with one leg pulled up to the stomach), gently pushing them into anal hole index finger.
• Before using suppositories, you should wait for natural bowel movements or do an enema so that the drug does not leave the intestine immediately after administration.
• To dispense the suspension, it is recommended to use a measuring syringe, which is sold along with the bottle. Before drawing the solution with a syringe, you need to vigorously shake the bottle so that all the ingredients are well mixed and distributed evenly.
• The dosage of liquid Panadol is determined based on weight and age. For each individual child, you can see it in the table, which is on the box and inside the paper instructions included with the bottle. There are also marked single doses drug, and daily allowance.

• In order not to be mistaken with the maximum allowed amount of syrup, it should be calculated by body weight. In childhood, do not give more than 15 mg of paracetamol per 1 kilogram, and a child can receive a maximum of 60 mg/kg per day.
• The frequency of use of both the suspension and suppositories is 3-4 times a day. The drug is given to swallow or injected into the rectum at intervals of 4-6 hours, but Panadol should not be used more than four times a day.
• The duration of taking Panadol Baby depends on the reason for its prescription and is adjusted by the doctor. If a child has pain or fever, and it is not possible to show the baby to a doctor, it is allowed to use the medication without consultation for no longer than three days.
• If the medicine is prescribed by a doctor for a period of more than 7 days, the risk of side effects must be monitored. In particular, with such long-term use, the child needs to have blood tests and check functional state liver.