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Medicinal reference book geotar. Talinolol (Talinolol) - instructions for use, pharmacological action, indications for use, dosage and method of administration, contraindications, side effects Side effects and effects of the drug

Name:

Talinolol (Talinololum)

Pharmacological action:

Cardioselective (selectively acting on beta-adrenergic structures of the heart) beta-blocker. It has a moderate negative inotropic and chronotropic effect on the heart (reduces the strength and frequency of heart contractions), does not affect bronchial beta2-adrenergic receptors. It has a hypotensive (blood pressure-lowering) effect without causing orthostatic hypotension (a drop in blood pressure when moving from a horizontal to a vertical position). It has an antiarrhythmic effect in case of sinus tachycardia (rapid heartbeat) and supraventricular and ventricular cardiac arrhythmias.

Indications for use:

Prescribed for angina pectoris, arterial hypertension (increased blood pressure), heart rhythm disturbances (supraventricular and ventricular extrasystole, paroxysmal tachycardia, atrial flutter and fibrillation, ventricular tachycardia).

Method of application:

Take orally, starting from 0.05 g (1 tablet 3 times a day). If necessary, increase the dose to 2 tablets 3 times a day. The maximum daily dose is 400-600 mg.

Adverse events:

Possible side effects: feeling of heat, dizziness, nausea, vomiting.

Contraindications:

Atrioventricular block II-III degree (impaired transmission of impulses through the conduction system of the heart), bradycardia, arterial hypotension, acute and chronic heart failure. Caution should be exercised when prescribing the drug to pregnant women.

Release form of the drug:

Dragee 0.05 g (50 mg) in a package of 50 pieces.

Storage conditions:

Drug from list B. Under normal conditions.

Synonyms:

Cordanum.

Drugs with similar effects:

Nebival Bicard Tenochek Acebutolol Betaxolol

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| Talinolol

Analogs (generics, synonyms)

Cordanum

Recipe (international)

Rp.: Dr. "Talinolol" 0.005 No. 10
D.S. Take 1 dr. orally 3 times a day.

Pharmacological action

Pharmacological action - antianginal, hypotensive, antiarrhythmic.
Selectively blocks beta1-adrenergic receptors of the heart. Reduces the automatism of the sinus node, exhibits moderate negative chrono-, ino- and dromotropic activity, and normalizes the baroreflex response. Lowers blood pressure (the hypotensive effect reaches a maximum after 5 hours, lasts 24 hours and stabilizes in the 2nd week of treatment).

Reduces myocardial oxygen demand, the severity of left ventricular diastolic dysfunction, and increases tolerance to physical activity. Reduces the level of plasma norepinephrine, eliminates hyperactivation of the sympathoadrenal system: dysfunction and death of cardiomyocytes (necrosis and apoptosis), deterioration of hemodynamics, decrease in the density and affinity of beta-adrenergic receptors, chronic tachycardia, myocardial hypertrophy, induction of myocardial ischemia (due to tachycardia, myocardial hypertrophy and vasoconstriction) and provocation of arrhythmias. By reducing the level of norepinephrine, it prevents increased renin synthesis and breaks the “vicious circle” of mutual activation of the renin-angiotensin-aldosterone and sympathoadrenal systems. In acute myocardial infarction, it reduces mortality and the frequency of relapses by reducing the ischemic zone and the frequency of rhythm disturbances. Does not have a negative effect on lipid metabolism.

Directions for use

For adults: Take orally, starting from 0.05 g (1 tablet) 3 times a day (before meals). If necessary, increase the dose to 2 tablets 3 times a day. For severe unstable angina, 10 mg is administered intravenously slowly.
If the effect is insufficient, after 10 minutes the administration of the drug can be repeated at the same dose. In these patients, talinolol can also be used as an intravenous drip infusion at a total dose of 30-60 mg per 200 ml of isotonic sodium chloride solution for 24 hours.

In case of acute myocardial infarction, it is prescribed from the first day of the disease - intravenously 10-20 mg/hour; total dose up to 50 mg. On the second day - intravenously at a dose of 50% of the dose of the first day.

You can prescribe the drug re ros (by mouth) in a daily dose of 100-200 mg (up to 300 mg).
For secondary prevention of myocardial infarction, 100-200 mg per os in 1 or 2 doses. Start treatment only on the recommendation of a doctor.

Indications

IHD: angina (tension, unstable)
- acute myocardial infarction (treatment and prevention);
- arterial hypertension, diastolic heart failure, supraventricular and ventricular extrasystole, paroxysmal tachycardia, atrial flutter and fibrillation, hyperkinetic cardiac syndrome, neurocirculatory dystonia of the hypertensive type

Contraindications

Hypersensitivity
- cardiogenic shock
- severe bradycardia (less than 50 beats/min)
- disturbances of AV (II–III degree) and sinoauricular conduction
- sick sinus syndrome
- heart failure (NYHA grade III–IV) with a significant decrease in left ventricular systolic function
- acute myocardial infarction with complications (bradycardia, hypotension, left ventricular failure)
- severe hypotension
- bronchial asthma
- diabetes mellitus (decompensated form)
- breastfeeding.

Side effects

From the nervous system and sensory organs: dizziness, headache, drowsiness, lethargy, sleep disorders, visual impairment, rarely - depression, hallucinations, psychosis; decreased secretion of tear fluid, hearing impairment.
- From the cardiovascular system and blood (hematopoiesis, hemostasis): sinus bradycardia, AV block, hypotension, rarely - impaired peripheral circulation (cold extremities).
- From the gastrointestinal tract: dyspeptic symptoms, abdominal pain, hypoglycemia, cholestatic hepatosis (extremely rare).
- Other: bronchospasm, convulsions, weight gain, decreased potency, alopecia, exanthema, hyperhidrosis, feeling of heat.

Release form

Dragees of 0.005 and 0.1 g (50 and 100 mg) in a package of 10 pieces; ampoules of 5 ml containing 10 mg of the drug, in a package of 10 pieces.

ATTENTION!

The information on the page you are viewing is created for informational purposes only and does not in any way promote self-medication. The resource is intended to provide healthcare workers with additional information about certain medications, thereby increasing their level of professionalism. The use of the drug "" necessarily requires consultation with a specialist, as well as his recommendations on the method of use and dosage of the medicine you have chosen.

Name: Talinolol (Talinololum)

Pharmacological effects:
Cardioselective beta-adrenergic receptor (selectively affects beta-adrenergic receptors of the heart). It has a moderate negative inotropic and chronotropic effect on the heart (reduces the strength and frequency of heart contractions), does not affect the beta2-adrenergic receptors of the bronchi. It has a hypotensive (blood pressure-lowering) effect without causing orthostatic hypotension (a drop in blood pressure when moving from a horizontal to a vertical position).

Talinolol - indications for use:

Angina pectoris, acute myocardial infarction, secondary prevention of myocardial infarction.

Talinolol - method of application:

Take orally, starting from 0.05 g (1 tablet) 3 times a day (before meals). If necessary, increase the dose to 2 tablets 3 times a day. For severe unstable angina, 10 mg is administered intravenously slowly. If the effect is insufficient, after 10 minutes the administration of the drug can be repeated at the same dose. In these patients, it is also possible to use talinolol in the form of intravenous drip infusion at a total dose of 30-60 mg per 200 ml of isotonic sodium chloride solution for 24 hours.
In case of acute myocardial infarction, 10-20 mg/hour is prescribed intravenously from the first day of the disease; total dosage up to 50 mg. On the second day - intravenously at a dose of 50% of the dosage of the first day. It is possible to prescribe the drug re ros (by mouth) in a daily dose of 100-200 mg (up to 300 mg).
For secondary prevention of myocardial infarction, 100-200 mg peros in 1 or 2 doses. Start treatment only on the recommendation of a doctor.

Talinolol - side effects:

Possible side effects: feeling of heat, dizziness, nausea, vomiting, hypotension (low blood pressure), bradycardia (low heart rate), bronchospasm (sharp narrowing of the bronchial lumen).

Talinolol - contraindications:

The drug is contraindicated in patients with sinus bradycardia (rare pulse), incomplete or complete atrioventricular block (impaired conduction of excitation through the heart), with severe right and left ventricular heart failure, with bronchial asthma and a tendency to bronchospasm, diabetes mellitus with ketoacidosis (acidification from - due to excessive levels of ketone bodies in the blood), disturbances of peripheral arterial blood flow, cardiogenic shock complicated by bradycardia, hypotension, left ventricular failure. Caution should be exercised when prescribing the medicine to pregnant women.

Talinolol - release form:

Dragees of 0.005 and 0.1 g (50 and 100 mg) in a package of 10 pieces; ampoules of 5 ml containing 10 mg of medication, in a package of 10 pieces.

Talinolol - storage conditions:

List B. Under normal conditions.

Talinolol - synonyms:

Cordanum.

Important!
Before using the medicine Talinolol you should consult your doctor. This instruction is intended for informational purposes only.

Talinolol (Talinololum)

Pharmacological action of the drug.

What is it used for? Indications for use of the drug.

Dosage and method of application.

Take orally, starting from 0.05 g (1 tablet 3 times a day). If necessary, increase the dose to 2 tablets 3 times a day. The maximum daily dose is 400-600 mg.

Side effects and actions of the drug.

Possible side effects: feeling of heat, dizziness, nausea, vomiting.

Contraindications and negative properties.

Release form. Package.

Dragee 0.05 g (50 mg) in a package of 50 pieces.

Storage conditions and periods.

List B. Under normal conditions.

Analogs of the drug.

Cordanum.

The main active ingredient of the drug.

talinolol

Important!

Description of the drug " Talinolol"on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Description

Detailed description

Detailed description

Pharmacological action

Selectively blocks beta 1-adrenergic receptors of the heart. Reduces the automatism of the sinus node, exhibits moderate negative chrono-, ino- and dromotropic activity, and normalizes the baroreflex response. Lowers blood pressure (the hypotensive effect reaches a maximum after 5 hours, lasts 24 hours and stabilizes in the 2nd week of treatment). Reduces myocardial oxygen demand, the severity of left ventricular diastolic dysfunction, and increases tolerance to physical activity. Reduces the level of plasma norepinephrine, eliminates hyperactivation of the sympathoadrenal system: dysfunction and death of cardiomyocytes (necrosis and apoptosis), deterioration of hemodynamics, decrease in the density and affinity of beta-adrenergic receptors, chronic tachycardia, myocardial hypertrophy, induction of myocardial ischemia (due to tachycardia, myocardial hypertrophy and vasoconstriction) and provocation of arrhythmias. By reducing the level of norepinephrine, it prevents increased renin synthesis and breaks the “vicious circle” of mutual activation of the renin-angiotensin-aldosterone and sympathoadrenal systems. In acute myocardial infarction, it reduces mortality and the frequency of relapses by reducing the ischemic zone and the frequency of rhythm disturbances. Does not have a negative effect on lipid metabolism.

In experimental studies on pregnant rats, short-term administration in doses of 300 mg/kg/day (orally) or 12.5 mg/kg/day (iv) was accompanied by a toxic effect on the maternal body, impaired development of the embryo and fetus (increased frequency of post-implantation death , decreased fetal or newborn body weight).

When taken orally, it is absorbed from the gastrointestinal tract by 50–70% (food intake reduces absorption). Bioavailability - 40–70%. Cmax in plasma is observed after 1.7–4 hours, AUC - 939–1703 (ng/ml) hours. The connection with plasma proteins is 50%, T1/2 is 8.7–17.8 hours. It is practically not biotransformed (less than 1%), excreted in the urine (60%) and through the intestines (40%). After intravenous administration at a dose of 30 mg, Cmax in plasma is 536–726 ng/ml, AUC is 1280–1586 (ng/ml)h. T1/2 - 7.3–18.2 hours. Volume of distribution - 2.5–3.3 l/kg. Secreted into breast milk.

Contraindications

Hypersensitivity, cardiogenic shock, severe bradycardia (less than 50 beats/min), AV disorders (grades II–III) and sinoauricular conduction, sick sinus syndrome, heart failure (NYHA grades III–IV) with a significant decrease in left ventricular systolic function , acute myocardial infarction with complications (bradycardia, hypotension, left ventricular failure), severe hypotension, bronchial asthma, diabetes mellitus (decompensated form), breastfeeding.

Use during pregnancy and breastfeeding

Possibly if the expected effect of therapy exceeds the potential risk to the fetus. Breastfeeding should be stopped during treatment.

Side effects

From the nervous system and sensory organs: dizziness, headache, drowsiness, lethargy, sleep disorders, visual impairment, rarely - depression, hallucinations, psychosis; decreased secretion of tear fluid, hearing impairment.

From the cardiovascular system and blood (hematopoiesis, hemostasis): sinus bradycardia, AV block, hypotension, rarely - impaired peripheral circulation (cold extremities).

From the gastrointestinal tract: dyspeptic symptoms, abdominal pain, hypoglycemia, cholestatic hepatosis (extremely rare).

Others: bronchospasm, convulsions, weight gain, decreased potency, alopecia, exanthema, hyperhidrosis, feeling of heat.

Interaction

Calcium antagonists (dihydropyridine derivatives) increase antianginal and hypotensive activity, but with intravenous administration they increase the likelihood of disturbances in myocardial conduction and contractility; ergotamine can increase peripheral circulatory disorders. Potentiates the negative chrono- and dromotropic effect of cardiac glycosides and class IA antiarrhythmic drugs, peripheral muscle relaxants. When combined with MAO inhibitors, arterial hypertension may develop during therapy and within 14 days after their discontinuation. NSAIDs weaken their antihypertensive properties (suppress the synthesis of PG in the kidneys and retain sodium and water). Sulfasalazine reduces plasma concentration, H 2 blockers increase (block hepatic biotransformation). Against the background of reserpine, clonidine, methyldopa, additive excess beta-adrenergic blockade is possible; beta-adrenergic agonists and methylxanthines - mutual suppression of action; phenothiazine - increased plasma concentrations of both drugs. Strengthens the inhibitory effect of alcohol and psychotropic drugs on the central nervous system, reduces the clearance of theophylline.

Overdose

Symptoms: nausea, vomiting, a sharp decrease in blood pressure with a weakening of the response to catecholamines (develop 30–240 minutes after the last dose), severe bradycardia, conduction disturbances, weakening of cardiac contractility, disturbance of intraventricular conduction, depression of the central nervous system (apathy, drowsiness, coma), convulsions, hypoxia, bronchospasm.

Treatment: gastric lavage, administration of activated charcoal and sodium sulfate, stabilization of acid-basic acid and electrolyte balance, oxygen therapy; maintaining cardiac activity (isadrin 1–4 mg IV bolus, then infusion 10 mg/100 ml; dobutamine 50–100 mcg, then infusion 300 mcg/100 ml; dopamine 0.25–0.4 mg/min, then 250 mg/100 ml; glucagon 5–10 mg over 5 minutes, then infusion 1–5 mg/hour); administration of atropine (IV, infusion, 0.5–2 mg over 8 hours), aminophylline IV 4–6 mg/kg for bronchospasm, diazepam (5–10 mg IV to relieve seizures). Temporary use of an artificial pacemaker is possible. Hemodialysis and hemoperfusion are ineffective.