Benzydamine hydrochloride: what it is, trade names. Benzydamine hydrochloride, what is it? Benzydamine drugs

Formula: C19H23N3O, chemical name: N,N-Dimethyl-3-[oxy]-1-propanamine (and as hydrochloride).
Pharmacological group: organotropic agents/gastrointestinal agents/dental agents; non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs/ other non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs.
Pharmacological action: analgesic, anti-inflammatory, antiseptic.

Pharmacological properties

Benzidamine stabilizes cell membranes, inhibits the formation of prostaglandins, and inhibits the enzyme cyclooxygenase. The antiseptic activity of benzydamine is especially pronounced against a number of microorganisms, including Gardnerella vaginalis. Benzidamine penetrates easily through mucous membranes and quickly reaches sites of inflammation. Benzydamine is excreted by the intestines and kidneys in the form of metabolites.

Indications

Inflammatory processes in the throat and oral cavity: pharyngitis, post-tonsillectomy conditions, gingivitis, aphthous ulcers, tonsillitis, stomatitis; inflammation of the oral mucosa after chemotherapy, radiation therapy and surgery; thrombophlebitis and phlebitis of the superficial veins of the lower extremities (as part of combined treatment), condition after phlebectomy and sclerosis of veins, postphlebitis syndromes; insufficiency of the leg veins, including during pregnancy; nonspecific vaginitis (occurring after radiation therapy, before and after operations in this area, the use of intrauterine pessaries), inflammatory processes in the os of the uterus, trichomonas and fungal infections, estrogen treatment in old age with an atrophied vagina.

Method of administration of benzydamine and dose

Tablets: 3 – 4 times a day, 3 mg (keep in the mouth until completely dissolved). Mouth or throat rinse: 15 ml (1 tablespoon) every 1.5 to 3 hours (do not swallow).
Aerosol (indicated for patients in the postoperative period and elderly patients in the absence of the ability to rinse their mouth) every 1.5 - 2 hours - adults - 4 - 8 doses, children under 6 years - 1 dose for every 4 kg of body weight (maximum - 4 doses), children 6 – 12 years old - 4 doses.
The gel is applied 2-3 times a day to the affected area and rubbed in with caution until completely absorbed. Vaginal rinsing is carried out 1-2 times a day: 1 sachet of powder is dissolved in 0.5 liters of water (the solution should be warm) and 140 ml is used for a single douching, the procedure must be carried out in a lying position, the liquid should be in the vagina for several minutes.
When using the gel, it is necessary to avoid contact with mucous membranes. Long-term (more than 1 week) therapy must be carried out under the supervision of a physician. Use benzydamine with caution during pregnancy and breastfeeding (aerosol, tablets, solution, powder). Avoid contact of benzydamine aerosol with the eyes.

Contraindications for use

Hypersensitivity, for tablets - phenylketonuria, for solution - age up to 12 years.

Restrictions on use

No data available.

Use during pregnancy and breastfeeding

No data available.

Side effects of benzydamine

Burning sensation and numbness of tissues in the oral cavity, dry mouth, allergic reactions (in the form of skin rash), drowsiness.

Among the drugs used simultaneously in several areas are drugs based on benzydamine hydrochloride (Benzydamine hcl). The substance has a large number of beneficial properties, which makes it effective in the treatment of various diseases. It can be used both topically and orally.

What is benzydamine hydrochloride - general information about the substance

A substance such as benzydamine (lat. Benzydaminum) is familiar to few, and not everyone knows that it is part of popular drugs.

The formula of the substance is C₁₉H₂₃N₃O. Belongs to the number of non-steroidal anti-inflammatory drugs. It also has analgesic and antipyretic properties. Benzydamine is suitable for relieving pain and swelling during injuries or after surgery, it can speed up wound healing. It is also effective for inflammatory diseases of the ENT organs.

For the treatment of infectious and inflammatory diseases, medications with this component are prescribed in combination with other drugs.

The substance is included in various types of drugs. On sale are:

1. Spray. It is prescribed for gargling and mouthwash. Available in 30 ml bottles.
2. Pills. They have a mint flavor and are designed to be sucked. They contain 0.03 g of active substance.
3. Solution (0.15%). This form of medication is used externally. Package volume is 120 ml.
4. Gel. It is used to treat wound surfaces. For wounds on the mucous membrane, this form of medication is prohibited.
5. Powder. It is supposed to be diluted to form a solution that is used for douching.

Benzydamine hydrochloride has an antiseptic and decongestant effect. It is also used as an analgesic. This allows it to be used topically as an anesthetic. The analgesic effect lasts for one and a half hours.

Destroys bacteria, suppresses the activity of Candida fungus. It is used for fungal diseases caused by reduced immunity and frequent use of antibiotics.

Benzidine hydrochloride easily penetrates mucous membranes. A small part of the substance binds to blood proteins. It is excreted by the kidneys and intestines.

Preparations containing this component are characterized by rapid action. The result of application becomes noticeable already on the first day.

Indications and contraindications

The scope of the medicine is very wide. It is used in dentistry, gynecology, and ENT practice. It is also suitable as an adjuvant for the treatment of cancer patients. Sometimes the drug is used to relieve swelling and relieve pain during surgical interventions.

The main indications for the use of benzydamine are:

• and ulcers on the mucous membranes of the mouth;
• pharyngitis;
• tonsillitis;
• laryngitis;
• surgery to remove tonsils;
• fungal infections of the reproductive system;
• trichomoniasis;
• vaginitis;
• inflammatory processes in the uterus;
• venous congestion in the legs;
• thrombophlebitis;
• problems with venous outflow;
• cancers treated with radiation therapy and chemotherapy.

The use of benzydamine is prohibited when:

• allergic reactions to the substance or other components of the drug;
• phenylketonuria (in this case you should not take benzydamine tablets);
• disturbances in the functioning of the heart;
• stomach ulcer;
• bronchial asthma.

There are no general recommendations for children, pregnant women and nursing mothers. If necessary, medications containing benzydamine should be prescribed by a doctor. Patients must strictly follow the instructions and instructions of the specialist, not exceeding the dosage and duration of the course.

Instructions for use

Features of use depend on the prescribed dosage form, disease and characteristics of the body.

Benzidamine in the form of a spray and solution is used once every 1.5-3 hours. The medicinal composition should not be swallowed.

Douching is done twice a day. For this purpose, a powder is used, which should be diluted with water.

Gel treatment is carried out up to 3 times a day. It should be applied to damaged areas of the skin until absorbed.

Precautions

The following rules must be observed:

1. Children under 12 years of age should not use the mouthwash.
2. Pregnant women and nursing mothers should be treated with such drugs only with a doctor's prescription.
3. Do not allow the medicine to come into contact with the eyes.
4. The gel should not be used on mucous membranes.
5. The usual duration of use of medications containing benzydamine is no more than 7 days. Longer treatment should be prescribed by a specialist.
6. Diseases of an infectious-inflammatory nature can be treated with this remedy only as part of combination therapy.

Side effects, drug interactions

Side effects are rarely reported.

The main ones include:

• feeling of dry mouth;
• burning at the application site;
• drowsiness;
• lethargy;
• increased sweating;
• tachycardia;
• skin rashes;
• digestive disorders (typical for children).

Minor manifestations of these symptoms do not require discontinuation of the medication. In case of severe side effects, it is necessary to adjust the treatment.

Benzidamine is often used in combination with other medications. It does not have a significant effect on their action. However, it is advisable to notify your doctor about taking any medications before prescribing.

Trade names, prices for analogue drugs

As a medicine, benzydamine is available under the trade names:

1. . This medicine is sold in tablets, sprays and as a solution. Its cost is 200-300 rubles.
2. Tantum rose. It can be found either in the form of a solution or in the form of a powder for its preparation. The price of the powder is 450-500 rubles, the solution - from 1100 rubles.
3. Tenflex. There are two forms of release of this medicine: spray and solution. It costs approximately 200 rubles.
4. Oralcept. This drug, which is based on benzydamine, is available in the form of a spray; you can buy it at a price of 250 rubles.

The following drugs can be called analogous.

1. . This is a herbal medicine. It is produced in the form of a solution and spray. Stomatofit-fresh rinses are also on sale. The cost varies from 120 to 200 rubles.
2. . The drug is presented in lozenges. It is based on medicinal plants. Its average price is 800 rubles.
3. . The medicine is released in the form of a gel. Its active component is cetylpyridinium chloride. In pharmacies the product can be purchased for an average of 300 rubles.
4. Novosept forte. The basis of the drug is the same substance as in the previous case. It is sold in the form of lozenges or spray. Its cost is 200-250 rubles.

You should select analogue medications together with your doctor. Self-medication, even with the use of natural drugs, can lead to complications.

Dosage form:  dosed topical spray Compound:

100 ml of topical spray dosed at 0.255 mg/dose contains:

Active ingredient: benzydamine hydrochloride - 0.150 g.

Excipients: glycerol, ethanol 96%, saccharin, sodium bicarbonate, methyl parahydroxybenzoate, peppermint leaf oil, polysorbate-20, purified water.

Description:

A clear, colorless solution with a characteristic mint odor.

Pharmacotherapeutic group: NSAID ATX:  

A.01.A.D.02 Benzydamine

G.02.C.C.03 Benzydamine

Pharmacodynamics:

Benzidamine is a non-steroidal anti-inflammatory drug that belongs to the indazoles group. It has an anti-inflammatory and local analgesic effect, and has an antiseptic effect against a wide range of microorganisms.

The mechanism of action of the drug is associated with the stabilization of cell membranes and inhibition of prostaglandin synthesis.

Benzidamine has an antibacterial and specific antimicrobial effect due to rapid penetration through the membranes of microorganisms with subsequent damage to cellular structures, disruption of metabolic processes and cell lysosomes.

Has an antimicrobial effect against Candidaalbicans. Causes structural modifications of the cell wall of fungi and their metabolic chains, thus preventing their reproduction, which was the basis for the use of benzydamine for inflammatory processes in the oral cavity, including infectious etiology.

Pharmacokinetics:

When applied topically, the drug is well absorbed through the mucous membranes and penetrates into inflamed tissues; it is found in the blood plasma in quantities insufficient to produce systemic effects.

Excretion of the drug occurs mainly by the kidneys, in the form of inactive metabolites or conjugation products.

Indications:

Symptomatic treatment of pain syndrome of inflammatory diseases of the oral cavity and ENT organs (of various etiologies):

• gingivitis, glossitis, stomatitis (including after radiation and chemotherapy);
• pharyngitis, laryngitis, tonsillitis;
• candidiasis of the oral mucosa (as part of combination therapy);
• calculous inflammation of the salivary glands;
• after surgical interventions and injuries (tonsillectomy, jaw fractures);
• after treatment and tooth extraction;
• periodontal disease.

For infectious and inflammatory diseases requiring systemic treatment, it is necessary to use the drug Benzidamine-Akrikhin as part of combination therapy.

Contraindications:

Hypersensitivity to benzydamine or other components of the drug.

Children under 3 years of age.

With caution:

Hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, bronchial asthma (including a history).

Pregnancy and lactation:

The drug Benzydamine-Akrikhin should not be used during pregnancy and breastfeeding.

Directions for use and dosage:

Locally, after meals.

One dose (one injection) corresponds to 0.255 mg of benzydamine.

Adults (including elderly patients) and children over 12 years of age 4-8 injections 2-6 times a day.

Children from 6 to 12 years old- 4 injections 2-6 times a day.

Children from 3 to 6 years old- 1 injection for every 4 kg of body weight, but no more than 4 injections (maximum single dose) 2-6 times a day.

The duration of treatment should not exceed 7 days. If after treatment there is no improvement within 7 days or new symptoms appear, you should consult your doctor.

Use the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.

Side effects:

The frequency of adverse reactions is given according to the following classification: very often (≥1/10), often (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10 000, <1/1000), очень редко (<1/10 000), частота не установлена (не может быть определена на основании имеющихся данных).

Local reactions: rarely - dry mouth, burning sensation in the mouth; frequency unknown - feeling of numbness in the mouth.

Allergic reactions: infrequently - photosensitivity; rarely - hypersensitivity reactions, skin rash, itching; very rarely - angioedema, laryngospasm; frequency unknown - anaphylactic reactions.

If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

Currently, no cases of overdose of Benzydamine-Akrikhin have been reported.

Symptoms : When using the drug in accordance with the instructions for use, an overdose is unlikely. If the drug is accidentally ingested, the following symptoms are possible: vomiting, abdominal cramps, anxiety, fear, hallucinations, convulsions, ataxia, fever, tachycardia, respiratory depression.

Treatment : symptomatic; empty the stomach by inducing vomiting, or flush the stomach using a gastric tube (under medical supervision); provide medical supervision, supportive care and necessary hydration. Antidote unknown.

Interaction: No interaction studies have been conducted with other drugs. Special instructions:

When using the drug Benzydamine-Akrikhin, hypersensitivity reactions may develop. In this case, it is recommended to stop treatment and consult a doctor to prescribe appropriate therapy.

In a limited number of patients, the presence of ulcers in the throat and mouth may indicate a more serious condition. If symptoms persist for more than 3 days, you should consult your doctor.

The use of Benzydamine-Akrikhin is not recommended in patients with hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs.

The drug Benzydamine-Akrikhin should be used with caution in patients with a history of bronchial asthma due to the possibility of developing bronchospasm while taking the drug.

The drug Benzydamine-Akrikhin contains parahydroxybenzoates, which can cause allergic reactions.

Impact on the ability to drive vehicles. Wed and fur.:

Does not affect the ability to drive vehicles and operate machinery.

Release form/dosage:Spray for topical use, dosed, 0.255 mg/dose. Package:

30 ml (176 doses) of the drug in a dark glass bottle, equipped with a dosing device with a spray nozzle and a transparent cap.

Gross formula

C19H23N3O

Pharmacological group of the substance Benzydamine

Nosological classification (ICD-10)

CAS code

642-72-8

Pharmacology

Pharmacological action- anti-inflammatory, analgesic, antiseptic.

Stabilizes cell membranes, inhibits cyclooxygenase, inhibits PG synthesis. Antiseptic activity is especially pronounced against a number of bacteria, incl. Gardnerella vaginalis.

Easily passes through mucous membranes, quickly penetrates into inflamed tissues. It is excreted in the form of metabolites by the kidneys and intestines.

Use of the substance Benzydamine

Inflammatory conditions of the mouth and throat: pharyngitis, aphthous ulcers, gingivitis, stomatitis, tonsillitis, post-tonsillectomy conditions; inflammation of the oral mucosa after radiation and chemotherapy, surgery; insufficiency of the veins of the lower extremities, incl. during pregnancy; phlebitis and thrombophlebitis of the superficial veins of the legs (combined therapy), condition after sclerotherapy of veins and phlebectomy, postphlebitis syndromes; nonspecific vaginitis (before and after surgery in the vaginal area, after radiation therapy, use of intrauterine pessaries), fungal and trichomonas infections, inflammation in the os of the uterus, estrogen therapy for an atrophied vagina in old age.

Contraindications

Hypersensitivity; for the solution - children's age (up to 12 years); for tablets - phenylketonuria.

Side effects of the substance Benzydamine

Numbness of tissues and a burning sensation in the mouth (lozenges), dry mouth, drowsiness, allergic reactions (skin rash).

Routes of administration

Locally.

Precautions for the substance Benzydamine

When using the gel, avoid contact with mucous membranes. Long-term (more than 7 days) treatment must be carried out under the supervision of a physician.

Prescribe with caution during pregnancy and breastfeeding (tablets, aerosol, powder, solution). Avoid contact of the aerosol with the eyes.

Interactions with other active ingredients

Trade names

Name	The value of the Vyshkowski Index ®
	0.0342
	0.0209
	0.0058
	0.0053
	0.0011

Benzydamine hydrochloride - this name is known only to a narrow circle of specialists. Patients know it as Tantum Verde. Already on the second day of its use, pain, burning, and discomfort in the throat decrease.

Operating principle

To relieve the inflammatory reaction, drugs from the group of non-steroidal anti-inflammatory drugs are prescribed.

Unlike other drugs with similar effects (analgesics, anesthetics, antipyretics), they have several advantages:

• They act simultaneously on pain, swelling, and inflammation.
• They have a wide range of applications.
• Effective for any pathologies.
• They have a minimal list of contraindications.
• Do not inhibit the functioning of the central and peripheral nervous system.
• Do not accumulate in the body.
• Convenient to use, as they are produced in any dosage forms.

Benzydamine hydrochloride belongs to the group of indazoles and, in addition to anti-inflammatory and analgesic properties, acts as an antiseptic with specific antimicrobial properties.

The main component benzydamine hydrochloride has several distinctive qualities:

• Has a high absorption rate.
• Quickly penetrates epithelial structures.
• Accumulating in the required concentration, it acts effectively at the site of inflammation.
• Local use ensures a low concentration of the substance in the blood, and this, in turn, makes it possible to avoid systemic effects on the body.
• Due to the ability to quickly penetrate cell membranes, it disrupts the metabolism of 110 types of pathogenic microorganisms and inhibits their reproduction.
• Has fungicidal properties (effective on 20 strains of fungi).
• It inhibits pain receptors locally, and at the same time affects the central parts of the brain responsible for pain sensitivity.
• It exhibits properties within 30 seconds and retains local anesthesia for about 2 hours.

And, most importantly, it gives a therapeutic effect on the first day of treatment.

There are now about 40 original patented non-steroidal anti-inflammatory drugs on the modern pharmaceutical market. But only one of them contains beznidamine hydrochloride. This is Tantum Verde - a product of the Italian pharmaceutical concern ANGELINI FRANCESCO A.C.R.A.F. S.p.A."

Application

All dosage forms of the drug are used topically, after meals, for otolaryngological and dental pathologies:

1. Lozenges (one unit contains 3 mg of active ingredient).
2. Solution for local irrigation and rinsing (1 ml – 1.5 mg) in a 120 ml bottle.
3. Spray (1 dose 2.5 mg) in a 30 ml bottle.

Dosage forms are prescribed for sore throat, pharyngitis, laryngitis, tonsillitis and candidiasis. In dentistry they are used for periodontal disease and sialadenitis.

For the treatment of infectious diseases and inflammatory processes of the throat, larynx and oral cavity of various etiologies, it is recommended to use a tablet form of the drug for resorption every 6 hours.

In case of severe pain, rinsing or irrigation every one and a half to two hours is recommended.

A metered spray is prescribed in one dose (one injection) 4 to 6 times a day.

For the treatment of children, the calculation of the daily dosage of the spray (according to the instructions) is carried out according to the formula taking into account body weight.

Tantum Verde does not contain antibiotic substances or dangerous auxiliary components, therefore the spray is actively used in pediatrics to treat children from 3 years of age.

Advantages of the form:

• Overdose of an aerosol and ingestion of the drug by a child are excluded.
• Absorption occurs gradually.
• Convenient to use at home.

Benzydamine hydrochloride is also included in the Tantum gel, which is indicated in the complex treatment of venous insufficiency. This is prescribed to patients with swelling and a chronic feeling of heaviness in the lower extremities, with nighttime muscle cramps, pain, phlebitis and thrombophlebitis. Gel Tantum is allowed to be used during pregnancy.

It is used externally, locally in the area of ​​projection of pain or swelling, by rubbing until completely absorbed four times a day.

Concern, based on benzydamine hydrochloride, produces the drug Tantum rose in the form of a powder for preparing a solution (1 sachet per 0.5 liter of water). Used in gynecological practice in the complex treatment of bacterial vaginosis, nonspecific and specific vulvovaginitis, cervicovaginitis.

For preventive purposes, it is prescribed before and after surgical interventions, as well as for hygienic procedures in the postpartum period.

Advantages

All dosage forms containing benzydamine hydrochloride meet the basic requirements for local drugs used to treat acute and chronic pathologies of the oropharynx.

Advantages:

• They have a wide spectrum of antimicrobial action.
• They do not cause a systemic toxic reaction.
• Does not irritate mucous membranes.
• Hypoallergenic.
• They can be used as single drugs and as part of combination therapy.

If other representatives of the group of non-steroidal anti-inflammatory drugs are based on weak acids, then benzydamine is a weak base. Thanks to this, the substance penetrates well into the inflammatory focus and accumulates in the required therapeutic concentration.

Due to the antimicrobial and antimycotic properties of the drugs, plaque disappears, and the mucous surfaces of the oropharynx are sanitized in the shortest possible time.

But, despite the fact that the drug is effective and safe for all age groups, only a specialist can make a rational choice in its favor and select an adequate treatment regimen.