Cough

My husband gives me caffeine injections. Medicinal reference book geotar

You can use caffeine in ampoules for cellulite not only in the salon, but also independently at home. Moreover, today ampoules, ointments and creams with this miraculous and effective fat burner can be purchased at a pharmacy without a prescription at a budget price. Regular beneficial anti-cellulite procedures will help restore smoothness and elasticity to the skin, as well as lose a couple of kilograms of weight, but you should know some rules for using caffeine, use it wisely and remember the contraindications.

Useful properties

Caffeine is a plant alkaloid found in coffee beans, tea leaves, guarana, kola nuts and some other plants. The substance is widely used in medicine and is included in medications to stimulate cardiac activity and respiration, combat migraines, and increase physical and mental activity.

In cosmetology, caffeine is included in gels, ointments, masks, scrubs and is used externally to combat visual imperfections of the skin and subcutaneous fat deposits.

Benefits of caffeine for skin include:

Stimulating the breakdown of fat deposits and, as a result, a positive effect on metabolism.
Skin moisturizing.
Antiseptic effect.
Stimulating microcirculation of blood and lymph.
Narrowing and cleansing skin pores.
Increasing the elasticity and firmness of the skin, muscle tone.
Removing excess fluid from cells and participating in their restoration.

All these properties help to successfully fight the most insidious enemy of a beautiful female body - cellulite (the orange peel effect on the skin). The combination of caffeine therapy with diet and regular physical activity gives a truly wonderful result: the skin looks healthy, elastic and smooth.

At home, you can use caffeine in combination with other active ingredients: blue and white clay, seaweed, honey, essential oils - and medications: Capsicum ointment, Papaverine ampoules, creams with camphor, menthol, rutin.

It should be taken into account that in addition to sodium caffeine benzoate, Capsicam ampoules contain additional substances: sodium hydroxide and water for injection, which together provide an amazing therapeutic and cosmetological effect.

Popular procedures

The most popular use of caffeine against cellulite is in wraps. Wrapping is a cosmetic procedure that involves applying creams, ointments and other products to problem areas of the body, followed by a tight application of cling film. Creating a greenhouse effect under the film accelerates blood circulation, sweating, removal of excess fluid and, accordingly, greatly enhances the effect of cosmetic products. Adding caffeine allows you to lose up to 1 cm of volume in just one session. Recipes for the most popular anti-cellulite wraps are presented below.

Hot touch: wrap with caffeine and Capsicam ointment. To carry out the procedure you will need:

4 ampoules of caffeine sodium benzoate;
Capsicum ointment;
1 tsp fat cream “Children”;
cling film.

In a ceramic container, mix baby cream, the contents of the ampoules and Capsicam (squeeze out a pea no more than 0.5-1 cm). Apply to problem areas (avoiding the abdomen and inner thighs) and cover with cling film. Wrap with a warm scarf. The duration of the procedure is 1 hour. When finished, rinse the mixture with water at room temperature and apply a nourishing cream.

One hour before the procedure, you should refrain from eating. The effect of Capsicam on the skin is very strong and is expressed in a rather intense burning sensation, so this procedure is not suitable for people with a low pain threshold.

Royal treatment: caffeine wrap with blue clay and essential oils. You need to prepare:

1 tbsp. white or blue clay;
2 ampoules of caffeine benzoate;
a few drops of grapefruit, orange or lemon essential oil;
1 tsp olive oil.

Pour warm water into the clay in a thin stream until a creamy mass is obtained. Add caffeine, essential and olive oil, apply to skin. Wrap the part of the body to be treated with cling film. The duration of the procedure is 40-60 minutes. Rinse off in the shower. Apply nourishing or baby cream.

Caffeine ampoules against cellulite in combination with cosmetic clay increase blood flow to problem areas and accelerate metabolic processes in skin cells. Essential oil has a relaxing effect on muscles, normalizes acid-base balance, and increases blood and lymph flow.

Honey treatment: wrap with caffeine, honey and Papaverine. To carry out the procedure you will need:

2 ampoules of Papaverine:
2 ampoules of caffeine sodium benzoate;
1 tbsp. l. honey

Mix all ingredients in a glass container. Heat slightly in a water bath. Before applying the mixture, prepare the skin for the procedure using a massage with a special brush or scrub. Apply the mixture to the prepared areas of the body, wrap with cling film and dress warmly. The duration of the procedure is 1 hour. Rinse with warm water and apply nourishing cream.

While wrapping with Papaverine, you can engage in physical exercise to enhance the effect. In this recipe, injection ampoules can, if desired, be replaced with ointment with Papaverine.

The most significant effect can be achieved if wraps are carried out in a course of 10-12 procedures. The interval between sessions should be 1-2 days. In cases of poor health, wraps can be done. To prepare masks, the same ingredients are used as for wraps, but the procedure is different. When applying the mask, cling film is not used, but it is recommended not to move until the mixture is completely dry or absorbed. Remains of the mask are removed with cosmetic wipes or washed off.

Contraindications

It should be remembered that caffeine benzoate, Capsicam, Papaverine and other ointments are still medications and have a number of contraindications for use. Caffeine wraps are contraindicated:

for cardiovascular diseases;
for oncological diseases;
during pregnancy and breastfeeding;
during menstruation;
with varicose veins;
for diabetes and endocrine diseases;
for fungal skin diseases;
for rashes of various etiologies;
for insomnia and neurological disorders.

If you have a history of health problems, you should consult your doctor before undergoing cosmetic procedures with caffeine. Wraps are contraindicated for colds, dizziness, and fever.

In any case, caution should be exercised when using ointments and medications.

A reasonable approach to anti-cellulite procedures with caffeine ampoules will delight you with excellent results without harm to health!

Solution for injection.

Basic physical and chemical properties: colorless transparent liquid.

Pharmacological group

Psychostimulants, drugs for use in attention deficit hyperactivity disorder (ADHD) and nootropics. Xanthine derivatives. ATX code N06B C01.

Pharmacological properties

Pharmacological.

Caffeine is an alkaloid found in tea leaves and coffee beans. The pharmacological properties of the drug are divided into central and peripheral. The central effects, in turn, are divided into psychostimulating and analeptic.

The psychostimulant effect of caffeine sodium benzoate is associated with its antagonism of adenosine in the mechanism of action on purinergic (adenosine) A-1 and A-2 receptors in the central nervous system (CNS). Adenosine is known to suppress central nervous system functions. Under the influence of the drug, mental activity, mental and physical performance increases. The psychostimulating effect is directly dependent on the dose. Small doses stimulate the functions of the central nervous system, large doses depress (due to depletion of nerve cells).

The analeptic effect of sodium caffeine benzoate is associated with its effect on the respiratory and hemodynamic centers of the medulla oblongata. As a result, there is an increase in the frequency and volume of inhalation.

The peripheral effects of the drug are ambiguous and related to its dose and level of influence on the vascular bed and myocardium. Coronary blood flow first increases and then decreases, renal blood flow increases, and the vessels of the abdominal cavity and skin narrow. Under the influence of the drug, central blood circulation is suppressed and cerebrospinal fluid pressure is reduced, which explains its effectiveness in migraines. The effect of the drug on the heart is ambiguous. In small doses it causes a positive inotropic effect, in higher doses it causes a positive chronotropic effect. In some people it can cause tachycardia and even arrhythmia.

Pharmacokinetics.

The drug is quickly distributed in all organs and tissues of the body. Communication with blood proteins (albumin) - 25-36%. Easily penetrates the blood-brain barrier and placenta. Passes into breast milk. The volume of distribution in adults is 0.4-0.6 l/kg, in newborns - 0.78-0.92 l/kg. More than 90% of the taken dose of the drug is metabolized in the liver, in children of the first year of life up to 10-15%. In adults, about 80% of a caffeine dose is metabolized to paraxanthine, about 10% to theobromine, and about 4% to theophylline. These combinations are demethylated into monomethylxanthines, and then into methylated uric acids. The half-life in adults is 3.9-5.3 hours (sometimes up to 10:00), in newborns (up to 4-7 months of age) - 65-130 hours. Caffeine and its metabolites are excreted by the kidneys (1-2% are excreted unchanged in adults, and up to 85% in newborns).

Indications

Infectious and other diseases accompanied by depression of the central nervous and cardiovascular systems; respiratory depression, asphyxia; poisoning with drugs and other substances that depress the central nervous system; asthenic syndrome spasms of cerebral vessels.

Contraindications

Hypersensitivity to xanthine derivatives and other components of the drug; increased excitability; insomnia, marked increase in blood pressure; atherosclerosis; organic diseases of the cardiovascular system, including acute myocardial infarction, paroxysmal tachycardia, arterial hypertension; glaucoma age over 60 years.

Special safety precautions

The effect on the central nervous system depends on the type of nervous system and can manifest itself as both excitation and inhibition of higher nervous activity.

Due to the fact that the effect of caffeine on blood pressure consists of vascular and cardiac components, both the effect of stimulating the heart and a slight inhibition of its activity can develop.

Use with caution in patients with a history of gastric and duodenal ulcers.

For apnea in newborns and infants in the postoperative period (prevention), use caffeine or caffeine citrate, but not caffeine sodium benzoate.

Interaction with other drugs and other types of interactions

When used simultaneously with other drugs, it is possible:

with alpha- and beta-adrenergic agonists, analgesics-antipyretics, clozapine, xanthine derivatives, psychostimulants, cardiac glycosides, thyroid-stimulating drugs - enhancing the effects of the above-mentioned drugs;

with anxiolytics, opioid analgesics, hypnotics and sedatives - weakening the effects of the above-mentioned drugs;

with antiarrhythmic drugs (mexiletine), hormonal oral contraceptives, disulfiram, enoxacin, erythromycin, isoniazid, methoxalen, norfloxacin, ofloxacin, cimetidine, ciprofloxacin - increased effects of caffeine

with antidepressants, barbiturates, beta-blockers, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin), cholestyramine, anticholinergics, - weakening the effects of caffeine

with medications that stimulate the central nervous system, drinks containing caffeine - excessive stimulation of the central nervous system;

with MAO inhibitors, procarbazine, furazolidone - dangerous arrhythmias or a pronounced increase in blood pressure;

with ergotamine - increased absorption of the latter from the digestive tract

with calcium preparations - weakening of absorption of the latter from the gastrointestinal tract

with lithium preparations - increased excretion of the latter in the urine;

with nicotine - increased excretion of caffeine in the urine.

The drug slightly increases the concentration of 5-hydroxyindoleacetic acid when determined in urine.

The drug slightly increases the concentration of catecholamines and vanillylmygdalic acid, which can lead to false-positive test results in the diagnosis of pheochromocytoma and neuroblastoma. The drug should not be used during tests.

The drug may lead to erroneous results when determining serum urate concentration using the Bittner method.

Features of application

Use during pregnancy or breastfeeding.

The drug should not be used during pregnancy and breastfeeding.

The ability to influence the reaction rate when driving a vehicle or working with other mechanisms.

During treatment, care should be taken when driving vehicles and operating machinery, and if side effects from the nervous system occur, refrain from potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Directions for use and doses

For adults, the drug is administered subcutaneously in a dose of 1-2 ml of a 10% solution (100-200 mg). The highest single dose is 400 mg, the maximum daily dose is 1 g.

For children over 12 years of age, the drug should be administered subcutaneously at a dose (depending on age) of 0.25-1 ml of a 10% solution (25-100 mg).

Children

The drug should not be used in children under 12 years of age.

Overdose

Symptoms: anxiety, agitation, restlessness, agitation, tremors or muscle twitching, epileptic seizures (in case of acute overdose - tonic-clonic seizures), hyperesthesia, atrial scotoma, tinnitus, headache, insomnia, confusion, delirium, delirium, tachycardia, arrhythmia, hyperthermia, frequent urination, dehydration, nausea, vomiting, sometimes with blood.

Treatment: support of pulmonary ventilation, oxygenation, maintenance of fluid and salt balance, hemodialysis, for epileptic seizures - intravenous diazepam, phenobarbital or phenytoin.

Composition and release form of the drug

1 ml - ampoules (10) - cardboard packs.
2 ml - ampoules (10) - cardboard packs.

Pharmacological action

Psychostimulant and analeptic drug, a methylxanthine derivative. Competitively blocks central and peripheral A1 and A2 adenosine receptors. Inhibits the activity of PDE in the central nervous system, heart, smooth muscle organs, skeletal muscles, adipose tissue, promotes the accumulation of cAMP and cGMP in them (this effect is observed when used only in high doses). Stimulates the centers of the medulla oblongata (respiratory and vasomotor), as well as the n.vagus center, has a direct stimulating effect on the cerebral cortex. In high doses, it facilitates interneuronal conduction in the spinal cord, enhancing spinal reflexes.

Increases mental and physical performance, stimulates mental activity, motor activity, shortens reaction time, temporarily reduces fatigue and drowsiness. In small doses the stimulating effect predominates, and in large doses the effect of depression of the nervous system predominates.

Speeds up and deepens breathing. Usually it has a positive ino-, chrono-, bathmo- and dromotropic effect (since the effect on the cardiovascular system consists of a direct stimulating effect on the myocardium and a simultaneous stimulating effect on the n.vagus centers, the resulting effect depends on the predominance of one or another action). Stimulates the vasomotor center and has a direct relaxing effect on the vascular wall, which leads to dilation of the vessels of the heart, skeletal muscles and kidneys, while the tone of the cerebral arteries increases (causes a narrowing of the blood vessels of the brain, which is accompanied by a decrease in cerebral blood flow and oxygen pressure in the brain).

Blood pressure changes under the influence of vascular and cardiac mechanisms of caffeine's influence: with normal initial blood pressure, caffeine does not change or slightly increases it; with arterial hypotension, it normalizes it.

It has an antispasmodic effect on smooth muscles (including a bronchodilator effect), and a stimulating effect on striated muscles.

Increases the secretory activity of the stomach.

It has a moderate diuretic effect, which is due to a decrease in the reabsorption of sodium and water ions in the proximal and distal renal tubules, as well as dilation of renal vessels and increased filtration in the renal glomeruli.

Reduces platelet aggregation and histamine release from mast cells.

Increases basal metabolism: increases glycogenolysis, increases lipolysis.

Indications

Diseases accompanied by depression of the central nervous system, functions of the cardiovascular and respiratory systems (including opioid poisoning, infectious diseases), cerebral vascular spasms, decreased mental and physical performance, drowsiness.

Contraindications

Arterial hypertension, organic diseases of the cardiovascular system (including severe), glaucoma, increased excitability, sleep disorders, old age.

Dosage

Administered subcutaneously or taken orally. Adults - 100-200 mg 2-3 times/day; children - 25-100 mg 2-3 times/day.

Side effects

From the side of the central nervous system: sleep disturbance, agitation, anxiety; With prolonged use, addiction is possible.

From the cardiovascular system: tachycardia, increased blood pressure, .

From the digestive system: nausea, vomiting.

Drug interactions

With simultaneous use, the effect of sleeping pills and anesthetics is reduced.

With simultaneous use, it is possible to enhance the effect of analgesics-antipyretics, salicylamide, naproxen.

With the simultaneous use of estrogens (hormonal contraceptives, drugs for HRT), it is possible to increase the intensity and duration of action of caffeine due to inhibition of the CYP1A2 isoenzyme by estrogens.

When administered concomitantly with adenosine, caffeine reduces the increased heart rate and blood pressure changes caused by adenosine infusion; reduces vasodilation caused by the action of adenosine.

With simultaneous use, it is possible to increase bioavailability, absorption rate and plasma concentration.

With simultaneous use, mexiletine reduces the clearance of caffeine and increases its plasma concentrations, apparently due to mexiletine inhibition of caffeine metabolism in the liver.

Methoxsalen reduces the excretion of caffeine from the body with a possible increase in its effect and the development of toxic effects.

Due to the induction of microsomal liver enzymes under the influence of phenytoin, its simultaneous use accelerates the metabolism and excretion of caffeine.

Fluconazole and terbinafine cause a moderate increase in the concentration of caffeine in the blood plasma, less pronounced.

The most pronounced increase in AUC and decrease in clearance are observed with simultaneous use of caffeine with enoxacin, ciprofloxacin, pipemidic acid; less pronounced changes - with pefloxacin, norfloxacin, fleroxacin.

When used simultaneously, caffeine accelerates the absorption of ergotamine.

Special instructions

It can be used as mono- or as part of combination therapy.

Included in the preparations

Included in the list (Order of the Government of the Russian Federation No. 2782-r dated December 30, 2014):

VED

ATX:

N.06.B.C.01 Caffeine

Pharmacodynamics:

Antagonism of central adenosine receptors, stimulation of the medulla oblongata centers (vagal, vasomotor and respiratory).

Stimulates the central nervous system, respiration, skeletal muscles, the secretion of pepsin and hydrochloric acid in the gastrointestinal tract, glycogenolysis. Increases the sensitivity of the respiratory center to the stimulating effect of carbon dioxide, increasing alveolar ventilation.

Increases the strength and frequency of heart contractions, cardiac output (positive inotropic effect on the myocardium and positive chronotropic effect on the sinoatrial node).

It has hypertensive and diuretic effects, stimulates cerebral vasoconstriction and reduces uterine contractility.

Pharmacokinetics:

The binding to plasma proteins is 25-36%. Biotransformation in the liver, in adults 80% of caffeine is metabolized into paraxanthine (1,7-dimethylxanthine), 10% into theobromine (3,7-dimethylxanthine) and 4% into (1,3-dimethylxanthine), compounds are demethylated into monomethylxanthines, and then into methylated uric acid derivatives. In premature babies it turns into. The half-life is 3-7 hours, in newborns - 65-130 hours, decreasing to adult levels at 4-7 months. Maximum concentration after 50-75 minutes. Excreted by the kidneys (in the form of metabolites, 1-2% unchanged), in newborns by the kidneys (85% unchanged).

Indications:

Diseases accompanied by depression of the cardiovascular and respiratory systems (including drug poisoning, infectious diseases).

CNS depression.

Spasms of cerebral vessels (including migraine).

Decreased mental and physical performance.

Enuresis in children.

Drowsiness.

Respiratory disorders (periodic breathing, idiopathic apnea) in newborns.

V.F50-F59.F51.1 Drowsiness [hypersomnia] of non-organic etiology

IX.I70-I79.I73 Other peripheral vascular diseases

VI.G40-G47.G43 Migraine

XVIII.R30-R39.R32 Urinary incontinence, unspecified

XVIII.R50-R69.R53 Malaise and fatigue

XIX.T36-T50.T40 Poisoning with drugs and psychodysleptics [hallucinogens]

XXI.Z70-Z76.Z73.6 Restrictions in activity caused by reduction or loss of ability to work

Contraindications:

Individual intolerance, including to other xanthines.

Anxiety disorders (agoraphobia, panic disorders).

Organic diseases of the cardiovascular system (including acute myocardial infarction, atherosclerosis).

Paroxysmal tachycardia, frequent ventricular extrasystole.

Arterial hypertension.

Sleep disturbances in the treatment of increased fatigue and drowsiness.

Children's age up to 12 years.

With caution:

Glaucoma.

Increased excitability.

Old age.

Epilepsy and tendency to seizures.

Pregnancy and breastfeeding.

Pregnancy and lactation:

FDA category C recommendations. Increased risk of spontaneous abortion, intrauterine growth retardation, fetal arrhythmia (high doses). Animal experiments: disturbance of skeletal development (fingers and individual phalanges) when using doses equivalent to the caffeine content of 12-24 cups of coffee per day, throughout pregnancy or with a single administration of large doses (50-100 mg/kg); in smaller doses - slowing down skeletal development.

Penetrates into breast milk (1% of its concentration in the mother's blood plasma). If a nursing mother drinks 6-8 cups of caffeine-containing drinks per day, the baby may develop hyperactivity and insomnia.

Directions for use and dosage:

Inside (regardless of food intake): adults - 0.05-0.1 g per dose 2-3 times a day (maximum daily dose - 1 g), children over 2 years old - 0.03-0.075 g per dose reception

P for migraines (often in combination with non-narcotic analgesics and ergot alkaloids) - 1-2 tablets during an attack of pain, then 1 tablet 2-3 times a day for several days (up to 1 month).

It is administered in the form of caffeine sodium benzoate subcutaneously: adults - 1 ml of 10% or 20% solution, children - 0.25-1 ml of 10% solution. To eliminate apnea in newborns - administered orally or intravenously(in the form of caffeine citrate), creating a concentration of caffeine base in the blood plasma from 3 to 10 mg/ml.

Side effects:

Nervous system: dizziness, headache, anxiety, irritability, nervousness, severe nervous excitement in newborns; tremor, sleep disturbance, muscle tension.

Cardiovascular system: rapid heartbeat.

Digestive system: diarrhea, nausea, vomiting, necrotizing enterocolitis.

Blood: hypoglycemia, hyperglycemia.

Overdose:

In case of overdose, pain in the abdomen or stomach is observed; agitation, anxiety, agitation or restlessness; confusion or delirium; dehydration; tachycardia, arrhythmia; frequent urination; headache; increased tactile or pain sensitivity; irritability; tremors or muscle twitching; nausea and vomiting, sometimes with blood; a painful, swollen belly or vomiting in newborns; ringing in the ears or sensation of other sounds; photopsia; epileptic seizures, usually clonic-tonic convulsions in acute overdose; sleep disturbance; trembling of the whole body in newborns.

Treatment is symptomatic - gastric lavage, if taken in the last 4 hours at a dose of more than 15 mg/kg and there was no vomiting caused by caffeine; , laxatives; for hemorrhagic gastritis - administration of antacid medications and gastric lavage with ice-cold 0.9% sodium chloride solution; maintaining pulmonary ventilation and oxygenation; for epileptic seizures - intravenously, - arrhythmias or severe hypertension (large doses); increased blood pressure and tachycardia (small doses).

Special instructions:

Sudden cessation of use may lead to increased inhibition of the central nervous system (drowsiness, depression).

The effect on the central nervous system depends on the type of nervous system and can manifest itself as both excitation and inhibition of higher nervous activity.

Due to the fact that the effect of caffeine on blood pressure consists of vascular and cardiac components, as a result, both the effect of stimulating the heart and inhibition (weak) of its activity can develop.

For apnea in newborns and infants in the postoperative period (prevention), either caffeine citrate is used, but not caffeine sodium benzoate. Excessive consumption during pregnancy can lead to spontaneous abortions, slowing of intrauterine development of the fetus, arrhythmia in the fetus; There may be disturbances in skeletal development when using large doses and a slowdown in skeletal development when using lower doses. Passes into breast milk in small quantities, but accumulates in infants and can cause hyperactivity and insomnia.

Instructions

Trade name of the drug: Caffeine sodium benzoate

International nonproprietary name:

caffeine

Dosage form:

solution for subcutaneous and subconjunctival administration

Compound

1 ml of solution contains 100 mg or 200 mg of sodium caffeine benzoate as an active substance and excipients - sodium hydroxide 0.1 M solution and water for injection.

Description

Transparent colorless or slightly colored liquid.

Pharmacotherapeutic group:

psychostimulant

ATX Code:

Pharmacodynamics

It has a psychostimulating and analeptic effect. It has a stimulating effect on the central nervous system (CNS), increasing excitation in the cerebral cortex, respiratory and vascular-motor centers, activates conditioned reflexes and physical performance, reduces drowsiness and fatigue, causes deepening and rapid breathing, increases heart rate, increases blood pressure pressure during hypotension, dilates the bronchi, bile ducts, blood vessels of skeletal muscles, reduces platelet aggregation, has a moderate diuretic effect, stimulates the secretion of gastric juice, increases basal metabolism and enhances glycogenolysis, causing hyperglycemia. Multiple pharmacological effects of the drug are due to the blockade of central and peripheral adenosine receptors. Inhibits phosphodiesterase, which leads to intracellular accumulation of cyclic adenosine monophosphate, under the influence of which glycogenolysis processes are enhanced, metabolic processes in organs and tissues are stimulated, including muscle tissue and the central nervous system.

When administered subconjunctivally, it improves microcirculation and activates the metabolic processes of the ciliary epithelium.

Pharmacokinetics

It is quickly distributed in all organs and tissues of the body, penetrates the blood-brain barrier and the placenta. The half-life is 3.9-5.3 hours (sometimes up to 10 hours). Communication with blood proteins (albumin) - 15%. More than 90% is metabolized in the liver, in children of the first years of life up to 10-15%. Caffeine is metabolized in the liver (the main part is demethylated and oxidized) with the formation of 5 metabolites. Caffeine and its metabolites are excreted by the kidneys (10% unchanged).

Indications for use

Decreased mental and physical performance, muscle weakness, drowsiness, migraine, moderate arterial hypotension, respiratory depression (including mild poisoning with opioid analgesics and hypnotics, carbon monoxide, asphyxia of newborns, restoration of the required level of pulmonary ventilation after the use of general anesthesia).
Hypotony of the eyeball (after abdominal eye surgery, ciliochoroidal retinal detachment, hypotonic retinal detachment).

Contraindicated

Hypersensitivity, organic diseases of the cardiovascular system (including acute myocardial infarction, atherosclerosis), arterial hypertension, glaucoma, sleep disorders, increased excitability, old age, paroxysmal tachycardia, frequent ventricular extrasystole, epilepsy and a tendency to seizures. Pregnancy and lactation period.

With caution: glaucoma, increased excitability, old age.

Directions for use and doses

Subcutaneously: adults 100 mg or 200 mg. The highest single dose for adults is 400 mg, the highest daily dose is 1 g. For children, 25-100 mg, depending on age. In ophthalmology, 30 mg is administered subconjunctivally once a day, daily. The number of injections depends on the intraocular pressure and the depth of the anterior chamber.

Side effect

From the nervous system: agitation, anxiety, tremor, headache, dizziness, epileptic seizures, increased tendon reflexes, tachypnea, insomnia. With sudden withdrawal - increased inhibition of the central nervous system, increased fatigue, drowsiness, increased muscle tone.

From the cardiovascular system: tachycardia, cardiac arrhythmia, increased blood pressure.

From the digestive system: nausea, vomiting, diarrhea, exacerbation of peptic ulcer.

Others: nasal congestion.

With long-term use, mild addiction is possible (a decrease in effect is associated with the formation of new adenosine receptors in brain cells), drug dependence.

Overdose

Symptoms: increased severity of side effects. In newborns (including premature infants) the following are possible: anxiety, tachypnea, tachycardia, tremor, increased Moro reflex, and at higher concentrations - convulsions.

Treatment: symptomatic therapy, oxygen therapy, hemodialysis. In newborns, if necessary, exchange blood transfusion.

Interaction with other drugs

With the combined use of caffeine and barbiturates, primidone, antiepileptic drugs (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase the clearance of caffeine.

Simultaneous use with cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin leads to a decrease in the metabolism of caffeine in the liver, a slowdown in its elimination and an increase in concentration in the blood.

When used with caffeinated beverages and other drugs that stimulate the central nervous system, excessive stimulation of the central nervous system is possible. Caffeine is an adenosine antagonist - large doses of adenosine may be required.

Mexiletine - reduces caffeine excretion by up to 50%; nicotine - increases the rate of caffeine elimination.

Monoamine oxidase inhibitors (MAOIs), furazolidone, procarbazine and selegiline - large doses of caffeine can cause the development of dangerous cardiac arrhythmias or a marked increase in blood pressure.

Caffeine reduces the effect of narcotic and sleeping pills. Increases the excretion of lithium preparations (Li +) in the urine.

Accelerates absorption and enhances the effect of cardiac glycosides. increases their toxicity.

Concomitant use of caffeine with beta-blockers may lead to mutual suppression of therapeutic effects; with adrenergic bronchodilators - to additional stimulation of the central nervous system and other additive toxic effects.

Caffeine may decrease the clearance of theophylline and possibly other xanthines, increasing the potential for additive pharmacodynamic and toxic effects.

Special instructions

It should be borne in mind that sudden cessation of use may lead to increased inhibition of the central nervous system (drowsiness, depression). The effect on the central nervous system can be manifested by both excitation and inhibition of higher nervous activity.

Release form

Solution for subcutaneous and subconjunctival administration 100 mg/ml or 200 mg/ml. 1 ml or 2 ml of 10% (100 mg/ml) or 20% (200 mg/ml) solution in neutral glass ampoules. 10 ampoules with instructions for use and a knife for opening ampoules or an ampoule scarifier in a cardboard box or 5 or 10 ampoules in a blister pack made of polyvinyl chloride film, 1 or 2 blister packs with instructions for use and a knife for opening ampoules or with an ampoule scarifier in a cardboard pack. When packaging ampoules with a break ring or break point, a knife for opening ampoules or an ampoule scarifier is not inserted.

Storage conditions

List B.

At temperatures from +15°C to +25°C Store out of the reach of children.

Best before date

6 years old. Do not use after the expiration date stated on the package.