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Canesten suppositories and vaginal tablets: instructions for use. Canesten: instructions for use of cream and suppositories

Kanesten– a synthetic antifungal drug for external use.
Clotrimazole, when used topically, inhibits the growth of the fungus by inhibiting protein synthesis in the cell. In addition, it inhibits the synthesis of membrane components - ergosterol, which leads to disruption of the integrity of the microbial cell and its further death. Pathogenic dermatophytes, yeasts and molds are sensitive to the action of canesten. When used topically, the substance is practically not absorbed into the blood, which makes Canesten safe for use in pregnant women and women during lactation. The active substance Canesten has a wide spectrum of antimycotic action, as well as fungistatic activity, which depends on the concentration at the site of infection. Canesten in any dosage forms is active against molds, yeast-like fungi, dermatophytes, pathogens of pityriasis versicolor and erythrasma. In addition to being antimycotic, Canesten has an antimicrobial effect against Trichomonas vaginalis, gram-positive and gram-negative microorganisms.

Indications for use

Spray and cream Kanesten recommended for use when:
Fungal diseases of the skin and mucous membranes, which are caused by molds, yeast-like fungi, dermatophytes, as well as other pathogens that are sensitive to clotrimazole: Mycoses of the hands, feet, skin folds and torso; Pityriasis versicolor and erythrasma.
Canesten vaginal cream and suppositories are used for: Candidiasis vulvitis; Balanitis; Vulvovaginitis. Canesten suppositories are also used according to the instructions for sanitizing the birth canal before childbirth.

Directions for use

Solution Kanestena used for douching, washing, applications, washing wounds.
Cream Kanesten Apply a thin layer to the affected areas 2-3 times a day. Depending on the type of lesion, the course of treatment with Canesten can range from 3 days for thrush to 4 weeks for erythrasma or lichen versicolor.
Vaginal tablets Kanesten injected deep into the vagina once a day, the duration of the course depends on the dosage, for example, 500 mg tablets of Canesten are administered once, 200 mg - once a day for 3 days, 100 mg - once a day for 6-7 days.

Side effects

Preparation Kanesten, as a rule, is well tolerated. But local reactions may occur in the form of burning, swelling, itching, redness, and the appearance of rashes (urticaria, blisters) at the site of application. Sometimes headache, nausea, vomiting, and abdominal pain may appear, which are signs of intolerance to clotrimazole.

Contraindications

Kanesten should not be used if you are hypersensitive to the components of the cream or tablets. The drug should not be used during menstruation or in the 1st trimester of pregnancy.

Interaction with other drugs

Concomitant use of amphotericin, nystatin or natamycin reduces the effectiveness of action Kanestena.

Pregnancy

You cannot use the drug Kanesten in the 1st trimester of pregnancy.

Overdose

Spray application Kanesten in higher doses does not cause any life-threatening reactions.

Storage conditions

Store at a temperature not exceeding 25°C, out of the reach of children. Shelf life - 3 years.

Release form

There are several forms of release of canesten:
Cream Kanesten 20 g in a tube containing 10 mg of clotrimazole per 1 g;
Vaginal tablets Kanesten(suppositories) containing 100, 200 and 500 mg of clotrimazole;
Solution for external use Kanesten.

Compound

Cream for external use 1% homogeneous, white - 1 g
clotrimazole 10 mg
Excipients: benzyl alcohol, cetyl palmitate, cetostearyl alcohol, purified water, 2-octyldodecanol, polysorbate 60, sorbitan stearate.
Spray for external use 1% in the form of a clear solution from colorless to slightly yellowish - 1 ml
clotrimazole 10 mg
Excipients: isopropyl myristate, macrogol 400, isopropanol.

Basic parameters

Name:	KANESTEN
ATX code:	D01AC01 -

Latin name: Canesten
ATX code: D01AC01
Active ingredient: Clotrimazole
Manufacturer: Bayer, Germany
Conditions for dispensing from a pharmacy: Over the counter

Canesten is a topical antifungal agent. Its versatility lies in its ability to treat genitourinary infections caused by various microorganisms - Candida fungi, staphylococci, streptococci, vaginal gardnerella and gram-negative bacteria. The active component of the drug destroys the membranes of fungal cells, and they die.

Indications for use

Canesten is used in the treatment of sexually transmitted infections caused by organisms sensitive to clotrimazole. The main indications for its use are:

Balanitis
Dermatomycosis
Erythrasmas
Athlete's foot
Trichophytosis
Microscoporia
Stomatitis
Fungal erosion of fingers
Lichen
Trichomoniasis
Vulvitis
Candidiasis
Mycoses.

Canesten is also used in preparation for childbirth.

Compound

One Canesten suppository may contain 100, 200 or 500 mg of active substance. Other components of the drug include:

Crospovidone
Calcium lactate
Microcrystalline cellulose
Lactic acid
Hypromelose
Lactose monohydrate
Anhydrous colloidal silicon dioxide;
Magnesium stearate
Cornstarch.

The composition does not change in different forms of the drug.

Medicinal properties

In addition to the antimycotic effect, the product has an antimicrobial effect due to the suppression of ergosterol. It destroys gram-negative and gram-positive microbes. The product has a fungistatic or fungicidal effect. This depends on the degree of its concentration at the site of the disease.

The drug effectively destroys yeast-like and mold fungi, dermatophytes, staphylococci, streptococci, pathogens of erythrasma, Bacteroides, pityriasis, vaginal trichomonas and gardnerella.

Once in the circulatory system, clotrimazole is quickly eliminated from the body, providing only a local effect.

Release forms

The cost is about 2200 rubles.

Canesten can be found in the pharmacy in the following forms:

Spray 1% in 30 ml bottles
Cream 1% in tubes of 5, 20, 35 or 50 g
Cream 2% in tubes of 20 g
Vaginal cream 10% in tubes of 35 g
Vaginal suppositories of 100, 200 and 500 mg.

The spray is a transparent, colorless or yellowish solution.

Directions for use

A small amount of spray is sprayed onto the affected areas twice a day until the symptoms of the disease completely disappear. It can also be used vaginally by douching.

Suppositories are inserted into the vagina once a day. The duration of therapy is affected by the dosage:

100 mg suppositories are used for 5-7 days
200 mg suppositories are used for 3 days
500 mg suppositories are used once.

Canesten in the form of a white cream costs about 466 rubles. per tube 15 g.

Canesten in the form of suppositories or vaginal cream is inserted deep into the vagina every night. It is convenient to carry out the procedure using an applicator.

Canesten cream for external use is used twice a day, applying a small amount to the problem area and rubbing it into the skin. On average, treatment lasts a month, but for the following diseases the course is:

Dermatomycosis – 3-4 weeks
Candidiasis of the genital organs – 7-14 days
Erythrasma – from 2 weeks to a month
Ringworm - 3 weeks.

The price for a package of candles is 1320 rubles.

Pregnancy and lactation

There is no evidence that the drug affects the fetus, but it is still not recommended to use it during the first 3 months of pregnancy. At the same time, the drug can be used the rest of the time, but in the case of vaginal suppositories, they should be administered without the help of an applicator.

Contraindications

Contraindications for the use of the drug Canesten according to the instructions for use are:

Intolerance to clotrimazole and other components
Children up to 12 years old
The intravaginal form is not used during menstruation.

A doctor can prescribe vaginal suppositories to a girl over 11 years old, but they will need to be used without an applicator.

Precautions

You should be careful when using the drug, adhering to the following rules:

Treat both sexual partners simultaneously
Avoid contact of the cream with the mucous membranes of the eyes.
Do not use the product vaginally during menstruation
Patients with liver pathologies should have their function checked during treatment with the drug.
When used externally, do not apply bandages.
If signs of allergy appear, treatment with the drug is stopped
If there is no effect for a month, the diagnosis should be checked.

When treating onychomycosis, the nail plates are cut short, and their surface should be rough for better penetration of the active substances.

Drug interactions

Intravaginal forms of Canesten can increase the plasma concentration of the immunosuppressive drug Tacrolimus. Therefore, when treating both drugs simultaneously, the level of Tacrolimus in the blood serum must be taken into account and monitored.

Canesten reduces the effectiveness of other antifungal drugs and antibiotics, such as Natamycin or Nystatin.

Side effects

Intravaginal use of the drug is fraught with the occurrence of allergic reactions, which are expressed in noticeable weakness, shortness of breath and urticaria. The following symptoms may appear in the vagina and external genitalia:

Burning
Discharge
Swelling
Hyperemia
Discomfort

When applying the drug Canesten to the skin and mucous membranes, the following side effects are noted:

Swelling
Peeling skin
Skin rashes
Blisters.

Rarely, the patient may experience abdominal pain. Frequent urination, gastralgia, signs of cystitis, pain during sexual intercourse, as well as pain in the partner’s genitals are noted.

Overdose

Since the drug has no local effect and does not affect the body as a whole, there are usually no signs of overdose.

Conditions and shelf life

The medicine is stored for no more than 3 years in a dark place. No special temperature conditions are required.

Analogs

Candide is an antifungal drug manufactured by Glenmark Pharmaceuticals Ltd, India. The main active ingredient is clotrimazole.

The drug is available in several forms:

2% white vaginal gel
1% clear colorless solution
1% white or light yellow powder with a characteristic odor
White, biconvex vaginal tablets
1% white cream, uniform in consistency.

Price the drug is about 300 rubles. per solution, 125 rub. – gel, 350 rub. – powder, 260 rub. – cream and 80 rub. - pills.

All forms of the drug are used exclusively externally or intravaginally.

Candide is used in the treatment of fungal infections of the skin and mucous membranes. The main principle of action is to block the synthesis of proteins, ergosterol and nucleic acids in fungal cells. The drug is effective against molds, dimorphic and yeast-like fungi, trichomonas, dermatophytes and actinomycetes of the genus Nocardia.

Main advantages of the drug are:

Safety, possibility of use even for thrush in newborns
Quick elimination of unpleasant symptoms - itching, redness, burning and swelling
Almost complete absence of side effects.

The product also has its own flaws:

Regardless of the form of release, the drug has an exclusively local effect, destroying the fungus locally without affecting the cause of the disease.
In advanced forms of thrush, when the fungus has managed to penetrate deep into the mucous membrane, the remedy will have to be combined with other drugs.

Kanizon is a topical antifungal drug from the group of imidazole derivatives. This is another analogue produced by Agio Pharmaceuticals, India. The active substance is clotrimazole.

The drug has a pronounced fungicidal, bactericidal and desensitizing effect. It destroys dermatophytes, molds, staphylococci and streptococci, fungi of the genus Candida Corynebacterium minutissimum, pathogens of erythrasma, seborrhea, pityriasis versicolor, and vaginal trichomonas.

Kanizon is produced in the form of a white ointment and solution for external use, as well as vaginal cream and white oblong tablets.

Price vaginal cream – 60-70 rubles, solution – 95 rubles, tablets – 13 rubles. The ointment, which is applied externally, costs about 450 rubles.

Pros:

Single use
Efficiency
Can be used throughout the menstrual cycle.

Cons:

Price.

Clotrimazole

Clotrimazole is a topical antifungal agent produced by Synmedic Laboratories, India. The drug is used in the fight against actinomycetes of the genus Nocardia, dermatophytes, dimorphic, yeast-like and mold fungi. It destroys staphylococci and other gram-positive bacteria, Corynebacterium minutissimus and vaginal Trichomonas. The active substance is clotrimazole.

Clotrimazole is available in the form of cream, vaginal tablets, aerosol, and solution.

Price vaginal tablets are about 60 rubles, creams – 300 rubles. for 30 g, solution - 200 rubles. for 15 ml, aerosol – 75 rub.

Pros:

Minimal side effects
Can be used once.

Cons:

The therapeutic effect is achieved only with a mild course of the disease.

Canesten is available in various forms such as tablets, creams and suppositories. Belongs to the group of antimycotic drugs. Its action is aimed at destroying the disease-causing agent.

General characteristics

Consists of main and additional substances. The active compound is clotrimazole. 1 tablet contains 100 mg of this medicine. The mechanism of action is based on reducing the development of fungal microflora. It reduces the production of the main cell wall substance ergosterol. For this reason, there is no further development of fungi in the vagina. It acts only on vegetative forms. That is, the impact on disputes is very limited. That is why there are special treatment regimens for this medicine.

After contact with mucous membranes, the substance is absorbed into. Only a quarter of the drug enters the blood. The rest acts locally. The medicine will travel through the blood to the liver. There it is neutralized. It is released by the kidneys after a day.

It has a detrimental effect on various types of mycotic cells. First of all, its action destroys yeast-like fungi of the genus Candida. Actively influences the following groups:

types of mold fungi;
dermtophytes and trichophytes;
some gram-positive and gram-negative bacteria;
has an effect in high concentrations on Gardanelly vaginalis.

The duration of treatment depends on the stage and extent of the disease.

Candles

Canesten suppositories are used to treat thrush in women. They are produced in the form of an oblong shape of a yellowish color. The active substance clotrimazole has a detrimental effect on fungi of the genus Candida. The peculiarity is the absence of inhibition of the growth of its microflora. This means that after treatment with these suppositories there is no need to use various biotic substances to normalize the vaginal microflora.

It is recommended to use candles once a day for a week. It is advisable to carry out treatment before bedtime. This will ensure the formation of the desired effect on the fungal flora. Candles should be used in accordance with the recommendations:

the suppository must be inserted in a lying position;
the candle should be inserted as far as possible;
this ensures maximum absorption of the substance from the vaginal mucosa;
After administration, you should lie down for 10-15 minutes so that the candle does not leak back.

Suppositories are often used as complex therapy. The price of Canesten candles is within 300 rubles. One package is enough for the entire course of treatment. There are several types depending on the amount of the main substance. The maximum concentration is 500 mg. Only 1 suppository is available in this dose. It is intended for loading dose. It is used for severe vaginal candidiasis.

The 100 mg release contains 6 suppositories. The course of treatment in this case is 6 days. The treatment regimen is chosen by the doctor.

Indications and contraindications for the use of suppositories

Suppositories are used to treat the following diseases:

candidiasis of the vaginal mucosa or in another way;
inflammation in the form of vaginitis caused by fungi of the genus Candida;
long-term antibiotic therapy, in this case suppositories act as a preventive measure for the formation of thrush.

Contraindications include intolerance to drug components. If after insertion into the vagina itching and burning develop, you should stop taking it. This condition means that you are having an allergic reaction.

Special instructions for use

During treatment with suppositories, sexual activity should be limited. Therapy is always carried out simultaneously for both partners. This drug may reduce the barrier function of latex. Treatment with suppositories is not carried out at the time of menstruation. Since the drug is not absorbed in the required concentrations.

Ointment

Canesten ointment is used for fungal infections of the skin and mucous membranes. It has a detrimental effect on various types of mushrooms. When applied to the skin, a small part is absorbed into the blood. Most of it remains unchanged. This means that its use does not cause systemic side effects.

Use only for local purposes. It is used for fungal infections of the skin and mucous membranes of the vagina. Recommended for men for the treatment of balanitis associated with Candida fungi.

How to use the ointment correctly?

It is necessary to wash the affected area before applying. Then, with clean hands, take a small amount of cream and spread on the skin. It should be applied in a very thin layer. The cream should be used about 3 times during the day.

When treating candidiasis of the external genitalia in women, apply the cream to the skin in a thin layer. It is recommended to carry out therapy in the perineal area. In men, the cream is used for balanitis. In this case, a small part of the ointment is applied to the head of the genital organ and foreskin. If redness or burning occurs during application, rinse the cream with water and stop using.

Usually the course depends on the type of fungi that caused the disease. For candidiasis it is usually about 7 days. In some cases, therapy may be increased.

Indications for use of ointment

This dosage form is prescribed for the following diseases:

candidiasis of the external genitalia in men and women;
perineal candidiasis;
and skin folds;
diseases in the form of mycoses of the hands and skin of the body;
dermatomycosis and trichophytosis.

During pregnancy, it is not recommended for use during the first half. During lactation you should also refrain from using this medicine. It is often prescribed in complex therapy with similar suppositories for women. The price of Kanesten ointment is within 200 rubles. One tube is enough for the full course of therapy.

Analogs

For intolerance, there are similar drugs. These include Clotrimazole and Kandin cream. Indications for use remain the same as for the main medicine. You can buy medications at the pharmacy as prescribed by your doctor.

Conclusions:

Are you really happy with life with this disease? With its side effects? Are you ready to endure itching, hiding your feet from others, suffering from pain, losing your nails?

After all, a solution has long been invented, a drug that has saved thousands of people from such suffering -

Canesten is an antifungal drug (international name Clotrimazole). The drug belongs to the group of Imidazole derivatives for external and local use. Active against pathogenic dermatophytes Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, Epidermophyton floccosum, yeast and mold fungi of the genus Candida, Torulopsis glabrata, Malassezia furfur, Rhodotorula, as well as pathogens of erythrasma, pityriasis versicolor, gram-positive (Streptococcus, Staphylococcus, Corynebacterium minut issimum) and gram-negative bacteria (Gardnerella vaginalis, Bacteroides), as well as Trichomonas vaginalis.

Dosage form:

Vaginal cream.
Cream for external use.
Ointment for external use.
Powder for external use.
Vaginal tablets.
Solution for external use.

Indications for use of the drug

Canesten is used for the following diseases:

Fungal infections of mucous membranes and skin.
Dermatomycosis, dermatophytosis, trichophytosis, epidermophytosis, microsporia.
Candidiasis.
Stomatitis.
Interdigital fungal erosion, fungal paronychia.
Mycosis complicated by secondary pyoderma.
Candidiasis vulvitis, vulvovaginitis, balanitis.
Trichomoniasis.
Pityriasis versicolor, pityriasis versicolor.
Erythrasma.
Sanitation of the birth canal before childbirth.

Contraindications to the use of Canesten

Contraindications for this drug are as follows:

Hypersensitivity to the components of the drug.
Menstruation period for vaginal forms.
First trimester of pregnancy and lactation period.

Side effects

Canesten has the following side effects:

Burning, swelling, irritation and peeling of the skin.
Paresthesia, erythematous rashes, blistering.
Allergic reactions in the form of urticaria and itching.
Intravaginal administration: itching, burning, hyperemia, swelling of the mucous membrane, vaginal discharge.
Headache, gastralgia, frequent urination.
Intercurrent cystitis.
A burning sensation in the partner’s penis and pain during intercourse.

Directions for use and doses

Externally. Cream, ointment, solution is applied in a thin layer to the affected areas of the skin and mucous membranes 2-3 times a day and rubbed in slowly. The surface area for lubrication is 10 cm, and the cream column is 5 mm. The course is about 4 weeks and another 14 days.
Erythrasma is treated for 2-4 weeks. Tinea versicolor – 1-3 weeks. Before lubricating the feet, wash them with warm water and soap and dry them with a towel. After fungal therapy for the skin of the legs, continue treatment for another 2-3 weeks to avoid relapse.
Vaginal gel or cream is administered in portions of 5 g as deep as possible into the vagina once a day. Course – 3 days.
For candidal vulvitis and balanitis - 2-3 times a day. Course – 1-2 weeks. Vaginal tablets are administered as deep as possible into the vagina, 500 mg once, or 200 mg, course - 3 days, or 100 mg, course - 6-7 days (morning and evening). At the same time, therapy is combined with treatment of the external genitalia with ointment, cream or solution.
When sanitizing the birth canal, a single administration of one tablet is recommended.
For urethritis, the solution is instilled into the urethra. Course – 6 days.

Special instructions for use

When treating with Canesten you need to know:

Treatment of both sexual partners is required to stop the infection.
The second and third trimester of pregnancy does not involve treatment using a vaginal applicator.
When treating trichomoniasis, it is necessary to include treatment with chemotherapy drugs.
Occlusive dressings should not be applied to areas where the cream is applied.
Avoid contact of the cream with the mucous membranes of the eyes.
In patients with liver failure, liver condition should be monitored. If undesirable symptoms appear, stop treatment with the drug.
If there is no effect of treatment within 4 weeks, it is necessary to undergo a study and confirm the diagnosis.

Interaction with other drugs

With the simultaneous use of Amphotericin B, Nystatin, Natamycin with Clotrimazole, the therapeutic effect of the latter is reduced.

The drug is available without a prescription.

Kanisten must be stored at a temperature not exceeding 25º C away from children. The shelf life of the drug is 3 years.

Like any drug that has a number of side effects and contraindications, Kanisten should not be taken without a comprehensive study and diagnosis. Only a qualified doctor can guarantee successful treatment.

Canesten suppositories, the instructions for which give a clear idea of the purpose of the drug, are one of the most effective means of normalizing the microflora and eliminating all the negative manifestations of its growth.

The full functioning of the body is based on the interaction of many specific processes that form its structure. At the same time, the influence of fungal organisms takes a certain step in this endless process, participating in digestion and helping in the breakdown of products. This state of affairs is natural and inherent in nature itself. However, sometimes, as a result of certain failures of the immune system, the fungus begins to grow rapidly, having a negative impact on humans. In such conditions, restoring its natural concentration is a top priority.

Range of applications

Canesten is a strong antifungal drug based on clotrimazole, which, in turn, is an imidazole derivative. This substance has a wide spectrum of action on various types of fungal formations. Due to the effectiveness and relative safety of clotrimazole, drugs based on it are widely used in modern practice. This high popularity is due to the positive impact in the presence of the following categories of fungal formations:

moldy;
dermatophytes;
yeast;
actinomycetes.

These types of fungal infections are the causes of the formation of most ailments of the corresponding nature. At the same time, the positive dynamics of Canesten in relation to such infections determines its fairly widespread use. Based on this, we can highlight a list of diseases that can be treated with this remedy:

pityriasis versicolor;
candidal lesions;
dermatophytosis;
erythrasmas;
vulvitis;
balanitis;
vaginitis

This list of diseases allows you to understand how effective Canesten and its analogs produced on the basis of clotrimazole are. The effectiveness of this product speaks for itself. Using the drug as part of complex therapy can give positive results in the shortest possible time. At the same time, clotrimazole-containing drugs, and in particular Canesten, show the best results in the treatment of thrush.

Indications and contraindications

To perform procedures aimed at eliminating the effects of candidiasis, suppositories or vaginal tablets are used.

The instructions for using the drug in this case are quite simple. Canesten is inserted into the vagina mechanically once a day at night. In this case, the time of use of the drug depends on the intensity of damage to the mucous membranes and its depth. The initial stages of the disease require fairly quick and simple treatment, while its advanced stages require long-term use of the drug in combination with other methods.

Despite the relative safety of the drug Canesten, the instructions provide a list of contraindications, in the presence of which the use of the drug should be limited:

hypersensitivity to components;
presence of menstruation;
first trimester of pregnancy;
lactation period.

The presence of the above conditions is a reason to discontinue the drug. Moreover, its very appointment should only be carried out by a specialist observing the woman. It is he who determines the rules for taking the drug and the intensity of therapy. This is done on the basis of the clinical picture of the disease, observations and tests taken from the woman. Thus, vaginal localization of candidiasis implies suppositories or tablets, while the growth of infection on the external skin requires the use of other forms of medication, such as ointment or cream. The latter are applied in a thin layer to the affected areas. In this case, healthy skin should not be affected to avoid further spread of infection to it.

Therapy and side effects

Canesten itself is easily tolerated by the body. However, in some cases, some side effects are observed due to the individual characteristics of the body. They look like this:

irritation of the mucous membranes of the vagina;
swelling;
burning;
appearance of specific secretions.

The presence of the above symptoms indicates intolerance to the components of the drug and their non-acceptance by the body. Such a situation and the detection of at least one of these signs is a kind of signal, and also requires immediate notification of the doctor and replacement of the drug with other similar drugs. Moreover, similar symptoms can be observed in both women and men undergoing therapy.

Separately, treatment of vaginal manifestations of candidiasis should be considered. It involves not only relieving a woman of the symptoms of the disease, but also carrying out similar measures in relation to a man. This approach is necessary, since the man is most likely also a carrier of the infection. This statement applies only to a regular sexual partner, who is at greatest risk. As a rule, to implement this type of treatment, a cream or ointment is used that has a local effect. Therefore, it should be remembered that treating thrush is an important activity that requires a responsible approach. This is the only way to ensure the recovery of both the woman and her sexual partner, as well as guarantee their full recovery from the consequences of the disease.