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Andipal do I need a prescription? Side effects and overdose during treatment with Andipal

Andipal is a combination drug that contains analgin, dibazole, phenobarbital and papaverine hydrochloride. Thanks to this composition, the tablets relieve pain of various origins (from migraines to spasms of the gastrointestinal tract), lower blood pressure and dilate blood vessels and have a calming effect. Adults need to take 1-2 tablets twice or thrice a day for 7-10 days. Andipal can also be taken once to relieve headaches. The drug is prohibited for children under 14 years of age, pregnant and breastfeeding mothers. Also, when taking it, it is necessary to monitor the blood picture and be careful when driving vehicles and mechanisms that require quick reactions.

Does Andipal increase or decrease blood pressure?

Andipal lowers blood pressure, but is not a drug that can be used for a long time for hypertension. He has a weak therapeutic effect Therefore, it should be used for mild forms of diseases without complicated cases. Andipal is recommended for single use to quickly reduce blood pressure and eliminate headaches. If blood pressure is above 140-160 mmHg, then the drug will not only not help, but will also provoke a greater increase in pressure. And all because of dibazole, which is included in its composition, which first tones the walls of blood vessels, causes an increase in pressure, and then after half an hour the lability of the vascular bed begins, which entails a further decrease blood pressure.

Andipal during pregnancy

The instructions for the drug clearly state that it is prohibited to use the drug during breastfeeding and in the first trimester of pregnancy. But there are cases when even during pregnancy it can be prescribed, but only under the strict supervision of a doctor. To do this you need to pass laboratory tests to view the condition of the liver and blood picture. Andipal will help the expectant mother to quickly relieve headaches caused by increased blood pressure and alleviate the condition, but it is still better to use folk remedies if possible.

As an antispasmodic, it is used for spasms of peripheral and cerebral vessels. The drug lowers blood pressure and improves collateral circulation.

The combination of myotropic antispasmodics dibazole and papaverine hydrochloride with analgin enhances the analgesic effect for headaches and migraines.

The presence of phenobarbital in the drug contributes to the manifestation of a sedative effect and enhances the effect of other components.

Andipal: Instructions for use

Composition and release form

Andipal tablets- tablets white or white with weak yellow tint colors.

Compound: 1 table analgin - 0.25 g, dibazol - 0.02 g, phenobarbital - 0.02 g, papaverine hydrochloride - 0.02 g, excipients: starch; talc; stearic acid - sufficient quantity to obtain a tablet weighing 0.37 g.

Package: In contour-free packaging 10 pcs.

Manufacturer: Akrikhin (Russia).

Description: Round tablets of white or white with a yellowish tint, flat-cylindrical, with a chamfer and a score.

Compound: 1 tablet contains: active substances: metamizole sodium (analgin) - 0.25 g, phenobarbital - 0.02 g, bendazole (dibazol) - 0.02 g, papaverine hydrochloride - 0.02 g. Excipients: potato starch - 0 .04779 g, talc - 0.00925 g, stearic acid - 0.00296 g.

Package: 10 tablets in blister or cell-free packaging without insertion into a cardboard pack.

Manufacturer: Barnaul Medical Preparations Plant LLC.

Compound: 1 tablet contains: metamizole sodium (analgin) 250 mg, phenobarbital 20 mg, bendazole (dibazol) 20 mg, papaverine hydrochloride 20 mg. Excipients: potato starch - 46 mg, talc - 7 mg, stearic acid - 3 mg, calcium stearate - 4 mg.

Package: 10 or 20 tablets.

Manufacturer: LLC "Anzhero-Sudzhensky Chemical and Pharmaceutical Plant"

Indications for use

This drug is indicated for pain caused by spasm blood vessels leading to poor blood circulation in organs. It is also prescribed for initial stage hypertension in order to dilate blood vessels, helping to lower blood pressure. Another indication for the use of Andipal is migraine. In addition, Andipal is prescribed for spasmodic pain associated with the gastrointestinal tract, as well as:

Eye pain
Hypertensive (hypertensive) disease.
Essential (primary) hypertension
Secondary hypertension
Benign intracranial hypertension
Diseases characterized by increased blood pressure
Hypertensive heart disease
Hypertensive encephalopathy
Pain in the pelvis, abdomen and perineum
Headache
Chest pain when breathing
Sore throat
Pain in the heart area
Pain associated with urination
Tenesmus bladder
Abnormal blood pressure readings without diagnosis
Atypical facial pain
Elevated blood pressure without a diagnosis of hypertension
Defeats trigeminal nerve
Trigeminal neuralgia
Constant, unrelieved pain
Acute pain
Symptoms and signs related to the digestive system and abdominal cavity
Histamine headache syndrome
Chronic post-traumatic headache
Dysuria
Gallstone disease

Directions for use and doses

For adults- 1-2 tables each. 2-3 times a day. The course of treatment is 7-10 days.

If treatment is ineffective, the drug should be replaced or combined with other drugs (to achieve a hypotensive effect).

Andipal is contraindicated for children. Prescribing Andipal to children is possible only at the age of 14 years. More early age child is a contraindication. Phenobarbital, which is part of the drug, has a negative effect on the development of brain cells. When Andipal is systematically taken by children, the phenomenon of mental deficiency may occur. Before prescribing Andipal to children, the doctor should carefully read all available additional diseases in the child and try to find alternative treatment.

Special instructions

Care should be taken when working with machinery.
At long-term use it is necessary to monitor the blood picture.

Side effects

Side effects occur quite rarely. Possible allergies (including reactions immediate type, including anaphylactic shock), dyspeptic symptoms (nausea, diarrhea or constipation). Due to the fact that Andipal contains analgin, sometimes negative phenomena such as leukopenia, thrombocytopenia or agranulocytosis occur (due to the inhibitory effect on hematopoiesis - with long-term use of the drug). Due to the presence of phenobarbital in the composition, sometimes depression or ataxia occurs (this mainly applies to weakened patients and elderly patients).

Contraindications

Hypersensitivity, severe liver failure, renal failure, glucose-6-phosphate dehydrogenase deficiency, blood diseases, as well as:

hypersensitivity to the components included in the drug;
deficiency of glucose-6-phosphate dehydrogenase;
AV conduction disturbance;
severe dysfunction of the liver and kidneys;
blood diseases;
myasthenia gravis;
porphyria;
pregnancy (first trimester);
breast-feeding.

Drug interactions

Enhances the hypotensive effect of nitrates, slow blockers calcium channels, beta-blockers, ganglion blockers, diuretics (including furosemide, hypothiazide), myotropic antispasmodics.

A mutual increase in the risk of side effects is observed when used simultaneously with opioid analgesics.

Adsorbents, astringents, and enveloping drugs reduce the absorption of the drug in the gastrointestinal tract.

Pregnancy and lactation

The effect of phenobarbital on intrauterine development the fetus is extremely negative. Even that small dose, which is part of andipal, can lead to underdevelopment of the child’s brain. The nervous system also suffers. The risk of having a child with cerebral palsy syndrome is very high. Therefore, the question of whether it is possible to take Andipal during pregnancy still remains open. Doctors in most cases leave it to the discretion of the expectant mother. It should be borne in mind that many others antihypertensive drugs have a pronounced teratogenic (fetal killing) effect. Therefore, Andipal can be taken during pregnancy, but very carefully.

Overdose

Signs of andinpal overdose - dizziness, severe drowsiness, even collapse is possible. As first aid, gastric lavage and activated charcoal are used. The following shows symptomatic treatment(to neutralize the manifestations of overdose).

Andipal price

Andipal n10 tab from 43 rub.
Andipal Avexima tablets 20 pcs. from 72 rub.

Compound

Active ingredient: 1 tablet contains metamizole sodium - 0.25 g, bendazole hydrochloride - 0.02 g, papaverine hydrochloride - 0.02 g; excipients: potato starch, calcium stearate, talc.

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Pharmacological action

Combination drug with analgesic, antispasmodic and vasodilating effects due to the specific action of its components. The drug also exhibits weak antihypertensive and antipyretic effects.

Metamizole sodium is a non-steroidal anti-inflammatory drug (NSAID) of the group of pyrazolone derivatives, has anti-inflammatory, analgesic and antipyretic effects, the mechanism of action of which is due to inhibition of COX and blocking the synthesis of prostaglandins from arachidonic acid, as well as disruption of the conduction of painful extra- and proprioceptive impulses, an increase in the threshold of thalamic excitability centers of pain sensitivity, increased heat transfer. Bendazole hydrochloride has an antispasmodic, hypotensive effect, and also has a stimulating effect on the functions of the spinal cord, promotes functional restoration peripheral nerves, has a moderate immunostimulating effect. Papaverine hydrochloride has a myotropic, antispasmodic, and hypotensive effect. Blocks phosphodiesterase, promotes the accumulation of cAMP and a decrease in calcium content in the cell, relaxes smooth muscle vessels and internal organs.

When taken orally, it is quickly and completely absorbed. In the intestinal walls it is hydrolyzed to form an active metabolite. The action develops after 20-40 minutes and reaches a maximum after 2 hours. Metabolized in the liver. Excreted by the kidneys.

Indications for use

Pain syndrome associated with vasospasm smooth muscle.

Contraindications

Increased sensitivity to the components of the drug. Arterial hypotension, atrioventricular conduction disturbances, increased tone muscles, convulsive syndrome. Blood diseases - agranulocytosis, thrombocytopenia, neutropenia, hepatoporphyria, eosinophelia, increased levels of blood transaminases, severe liver and kidney dysfunction, coma, respiratory depression, broncho-obstructive syndrome, hemolytic anemia, pregnancy, breastfeeding period, childhood up to 18 years, age over 60 years, AV block, glaucoma, glucose-6-phosphate dehydrogenase deficiency.

Pregnancy and lactation

Directions for use and doses

Take 1-2 tablets orally 2-3 times a day. Maximum daily dose makes 4 tablets. The course of treatment is no more than 1-3 days. The tablets are taken after meals with a small amount of water.

If there is no effect from treatment, you should consult a doctor!

Side effect

From the gastrointestinal tract: nausea, constipation.

From the central side nervous system: drowsiness, increased sweating.

From the outside cardiovascular system: violation heart rate, decrease cardiac output, as a result of which the electrocardiogram may deteriorate.

Allergic reactions: skin rash, itching, urticaria, Quincke's edema

Metamizole sodium:

Allergic reactions. Uncommon: rash; rarely: maculopapular exanthema, anaphylactic or anaphylactoid reactions. Occurs mainly within the first hour after administration. Usually appear as skin reactions, such as itching, burning, redness, rash, swelling, rarely - shortness of breath. May occur with more severe forms, such as: urticaria, severe angioedema (including the larynx), severe bronchospasm, cardiac arrhythmia, arterial hypotension(sometimes preceded by an increase in blood pressure); very rare: analgesic-induced bronchial asthma(including in patients with aspirin-induced asthma), Stevens-Johnson syndrome or Lyell's syndrome, shock.

If skin reactions occur, taking metamizole sodium should be stopped immediately.

Blood and lymphatic system. Rare: leukopenia, agranulocytosis or thrombocytopenia. These reactions are probably immunological. They can occur even if metamizole sodium was previously used without complications. The risk of developing agranulocytosis may be increased if metamizole sodium is taken for more than 1 week.

Agranulocytosis appears high temperature, chills, sore throat, difficulty swallowing, inflammation of the mouth, nose, throat or genitals, or anal itching. The erythrocyte sedimentation rate (ESR) is significantly accelerated, the number of granulocytes is significantly reduced or completely absent. Typically, but not always, the values of hemoglobin, red blood cells and platelets remain within normal limits.

Metamizole sodium should be discontinued immediately, even if laboratory results are absent. diagnostic tests, subject to a sudden deterioration in the patient’s general condition.

Cardiovascular system. Uncommon: hypotensive reactions during or after use of the drug. Even with hyperthermia, a decrease in blood pressure may occur without any evidence of a hypersensitivity reaction.

Kidney diseases and urinary tract. Very rare: acute deterioration renal function, after which progeinuria, oligo- or anuria and acute renal failure, acute interstitial nephritis. Discoloration of urine red.

If side effects or other unusual reactions occur, consult your doctor about further use of the drug.

Overdose

Symptoms of metamizole poisoning: hypothermia, palpitations, shortness of breath, tinnitus, nausea, vomiting, weakness, drowsiness, impaired consciousness, convulsions; possible development of acute agrunolocytosis, acute renal and liver failure. Symptoms of papaverine poisoning: diplopia, weakness, drowsiness, lethargy. Symptoms of bendazole poisoning: arterial hypotension, headache, weakness.

Treatment: discontinuation of the drug, gastric lavage, administration of activated carbon,

symptomatic therapy aimed at maintaining vital important functions. The main metabolite of metamizole - 4 N-methyl-amino-antipyrine - can be eliminated by hemodialysis. Treatment of intoxication, as well as prevention serious complications, require intensive medical monitoring and treatment.

If symptoms of overdose appear, you should immediately seek medical advice. medical care!

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Interaction with other drugs

If you are taking any other medications, be sure to consult your doctor about the further use of Andipal.
When using the drug simultaneously with antispasmodics, sedatives, diuretics enhance the hypotensive effect. The drug reduces the effect of dopegyt, increases the hypoglycemic activity of oral antidiabetic drugs, enhances the effect of ethanol, indirect anticoagulants, glucocorticosteroids (GCS) and indomethacin. When used simultaneously with cyclosporine, the concentration of the latter in the blood decreases. The effectiveness of andipal is reduced by phenylbutazone, barbiturates and other inducers of microsomal liver enzymes; simultaneous administration with other non-narcotic analgesics, tricyclic antidepressants, hormonal contraceptives and allopurine leads to an increase in the toxic effect of andipal. Sedatives and tranquilizers enhance the analgesic effect of andipal. Thiamazole and sarcolysine increase the risk of developing hematopoietic disorders. The effect of andipal is enhanced by codeine, Hg receptor blockers and propranolol. Concomitant use with chlorpromazine or other phenothiazine derivatives can lead to the development of severe hypothermia; Caution is required when using the drug simultaneously with radiopaque agents, colloidal blood substitutes and penicillin, procainamide, reserpine, quinidine, salicylates; it is possible to reduce the hypotensive effect of methyldopa and the antiparkinsonian effect of levodopa.

Features of application

The ability to influence the reaction rate when driving a vehicle or working with other mechanisms.
During treatment with the drug, you should refrain from driving vehicles or working with complex mechanisms.
Children. Contraindicated.

Precautions

Before starting treatment, consult your doctor! Do not use the drug for longer than the prescribed period without a doctor’s recommendation! If the signs of the disease do not begin to disappear or, on the contrary, the state of health worsens, or adverse events, consult your doctor for advice regarding further use of the drug!

Before starting treatment, consult your doctor!

Papaverine and dibazole:

Short courses should be prescribed with caution and it is preferable to use short courses when treating people over 60 years of age, due to the possibility of a decrease in cardiac output and deterioration of electrocardiogram (ECG) indicators,

Only small doses of the drug should be used in people with traumatic brain injury, impaired liver and kidney function, hypothyroidism, and adrenal insufficiency, since the hypotensive effect of the drug is enhanced in them. In persons with benign hyperplasia prostate gland high doses The drug can provoke the development of acute urinary retention.

Use with caution in case of renal and/or liver failure; diseases of the bronchi, accompanied by excessive accumulation of secretions; a history of gastric bleeding.

Metamizole sodium:

Special instructions.

When using the drug, agranulocytosis may develop, and therefore, if an unmotivated increase in temperature, chills, sore throat, difficulty swallowing, stomatitis, as well as inflammation of the external genitalia and anus immediate discontinuation of the drug is necessary.

The risk of potentially severe anaphylactoid reactions to metamizole sodium is significantly increased in patients with:

Asthma syndrome or angioedema for non-narcotic analgesics;

Bronchial asthma with concomitant rhinosinusitis and urticaria;

Intolerance to dyes (tartrazine) and preservatives (benzoates);

Alcohol intolerance.

When prescribed to patients with acute cardiovascular pathology Careful monitoring of hemodynamics is necessary due to the hypotensive effect. Use with caution in patients with blood pressure (BP) below 100 mmHg, with myocardial infarction, multiple trauma, with anamnestic indications of liver and kidney diseases (pyelonephritis, glumerulonephritis), during treatment with cytostatics, and blood diseases. The risk of such reactions is also increased in patients with dehydration or dehydration, unstable blood pressure, or incipient circulatory failure (eg, patients with multiple injuries or heart attack) in patients with high fever.

These patients require careful evaluation and close monitoring. Preventative measures (such as circulatory stabilization) may be necessary to reduce the risk of hypotensive reactions.

Store in original packaging at a temperature not exceeding 25 °C. Keep out of the reach of children.

Andipal belongs to combination drugs that have vasodilating and analgesic properties. This medicine is used to relieve pain when muscle spasms occur. The medicine also has an antihypertensive effect, thanks to which it is possible to stabilize blood pressure. Before using Andipal, you need to study the instructions for its use and find out at what pressure to use the drug. Only in this case will it be possible to instantly relieve headaches and reduce blood pressure.

Andipal for pressure is an anti-inflammatory and analgesic drug that also has an antipyretic and analgesic effect on the body. The effectiveness of the drug is due to the components included in its composition. The main one is metamizole sodium, which helps cope with fever. Papaverine hydrochloride is also considered an important element, which is responsible for the tone of the muscles of internal organs and dilates blood vessels.

To increase the effectiveness of the drug, some use it in combination with other drugs. For this purpose, H-blockers, barbiturates and anaprilin are used. It is not recommended to use Andipal together with Tamerkazolil, as this increases the likelihood of leukopenia several times. Therefore, before use Andipala, it is better to read the instructions for its use for high blood pressure. This will help avoid serious side effects after using the medicine.

Conditions for dispensing from pharmacies

Before using Andipal, you need to familiarize yourself with the conditions for dispensing this medicine from pharmacies. Before purchasing the drug, you will have to contact your doctor to make an accurate diagnosis and confirm the need for its use in treatment. The doctor should also provide instructions on the use of Andipal and other medications for high blood pressure.

To establish a diagnosis, a visual inspection the patient and all his complaints about his health will be taken into account. If necessary, the person is referred to additional examinations, the results of which will help identify health problems. After an examination and an accurate diagnosis, the doctor prescribes a course of treatment in which the patient will have to take the prescribed medications.

A person will be able to purchase Andipal, like many other prescribed drugs and medicinal components, Requires a doctor's prescription. This medicine will not be sold without a prescription in any pharmacy.

Prices

The therapeutic effects of Andipal help to quickly eliminate high blood pressure and get rid of headaches. That is why many go to pharmacies to buy this medicine. Most people do not know the exact cost of the drug. On average, the price of Andipal for high blood pressure is 30–40 rubles per pack. To clarify the cost, it is recommended to independently visit the nearest pharmacy that may sell such tablets.

Release form and composition

The drug is sold in the form of small flat-cylindrical tablets. They may be yellowish or white. In pharmacies you can find various packages of this medicine, which differ in the number of tablets.

Packages are available containing 10, 30 or 100 tablets. The choice of package size depends on the daily dose of Andipal. At high blood pressure and for large dosages, buy a pack of 100 tablets.

It's no secret that this drug belongs to combined means which help reduce blood pressure. Therefore, the medicine contains the following elements:

Analgin. This component is added to Andipal to get rid of pain that often appears when blood pressure increases. Analgin also helps to cope with fever and lower elevated temperatures.
Papaverine. The substance is used to reduce vascular tone and weaken muscles.
Phenobarbital. Long-term use of Andipal is addictive in some patients. To reduce the likelihood of addiction, phenobarbital was added to the drug.
Disabol. This component is one of the most important, since it is responsible for reducing pressure.

Thanks to the above components from the composition, the drug performs several important functions. It is used to reduce body temperature or relieve pain.

Pharmacological effect

Many people are interested in whether Andipal lowers or increases blood pressure. To understand this, it is recommended that before using tablets you become familiar with their pharmacological effects on the body.

The medicine has complex impact on human body what makes it different from others similar drugs. Regular consumption of Andipal helps cope with high blood pressure and constant cramps. The tablets activate the functioning of the spinal cord and improve protective functions body.

Thanks to metamizole sodium, the combination drug copes well with persistent migraines and many forms of inflammation in the body. The anti-inflammatory effect is noticeable almost immediately after taking the tablets, since metamizole is quickly absorbed.

Sometimes Andipal is taken to solve sleep problems, since the tablets have hypnotic effect. Phenobarbital, which is part of the drug, is responsible for improving sleep.

The drug also has an antispasmodic and vasodilator effect and therefore is often used to combat organ spasms.

Indications for use

Before using Andipal for high blood pressure, you should familiarize yourself with the indications for the use of this medicine. Tablets are used in the treatment of many diseases, however, they are prescribed infrequently to hypotensive patients in order to prevent the occurrence of a hypotensive crisis.

The main indication for the use of the drug is considered to be a deviation of blood pressure from the norm. Therefore, tablets are often prescribed to people who have the first symptoms of hypertension. Doctors advise using the medicine systematically to get rid of high blood pressure.

It is recommended to use the drug for people suffering from severe migraines. Thanks to the antispasmodic and analgesic effect, you will be able to get rid of dizziness and headaches. In addition, Andipal is prescribed for the treatment of the following diseases:

apathetic painful sensations in the facial area;
changes in blood pressure;
nerve damage;
headaches that appear after injuries;

The drug is also prescribed to get rid of aching pain, which appeared as a result of spasms in the gastrointestinal tract or in the area of smooth muscles.

Contraindications

When taking Andipal to reduce blood pressure, be sure to take into account all contraindications to its use. It is also recommended to monitor your blood pressure. All this will help to avoid complications and not harm your health.

The main contraindication is childhood and therefore the medicine is not given to children under eight years of age. For adolescents and older children, the drug is prescribed only in extreme cases, since the tablets contain phenobarbital. This substance negatively affects children's brain cells.

People who suffer from:

allergies to components included in the drug;
renal failure;
hyperplasia;
poor intestinal permeability;
heart failure;
tachycardia;
liver failure.

If you ignore all of the above contraindications and use Andipal, which lowers blood pressure, then a person’s health condition may deteriorate sharply.

Use during pregnancy and lactation

Many women are interested in whether the product can be used during pregnancy and lactation. Most experts do not advise nursing or pregnant women to use the drug, as it is harmful to health.

Andipal is contraindicated in pregnant girls due to the phenobarbital contained in the tablets. This substance negatively affects the development of the fetus in the womb. Even a small amount of this component can disrupt the development of the baby's brain.

In addition, the substance disrupts the functioning of the nervous system and increases the likelihood of having a baby with cerebral palsy syndrome. Because of this, some doctors still cannot answer for sure whether pregnant women should take Andipal for hypertension in order to lower blood pressure. Some experts give expectant mothers the opportunity to decide for themselves whether they need to take this drug.

Instructions for use Andipal

To normalize blood pressure with the help of such tablets, it is recommended to familiarize yourself with the features of their use.

The medicine is available in the form of tablets and therefore it is necessary to determine the optimal amount that can be taken per day. If the optimal dose is not determined, the patient will experience an overdose of the drug, which is accompanied by vomiting, nausea and severe headache. To prevent this from happening, take 1-2 tablets at a time. In this case, the medicine is taken at least three times daily.

The duration of treatment directly depends on the disease and the characteristics of the patient’s body. Therefore, for some it is enough to take the pills for just a week, while others will have to be treated with the drug longer than a month. To determine the optimal duration of the treatment course, you should consult your doctor.

When using the drug, it is recommended to regularly visit your doctor so that he can monitor the course of treatment. If the drug does not help cope with high blood pressure, he will replace the drug with another one. It is not recommended to change treatment on your own, as this can significantly worsen the situation.

Side effects

At misuse Andipal may cause side effects in some patients negative impact on the body.

The main side effect is considered to be worsening blood clotting. Experts also say that due to non-compliance with dosages, patients develop depression caused by problems in the functioning of the nervous system. Also, in people who have taken Andipal for a long time with high blood pressure, motor activity worsens.

Doctors do not recommend using tablets for self-medication as painkillers. This treatment increases drowsiness and impairs liver function. Also, due to some components in Andipal, the following side effects appear:

constipation;
nausea with vomiting;
decrease in physical activity;
redness on skin due to an allergy to components of the composition;
anaphylactic shock.

In some patients, due to side effects, the components of the drug are less absorbed. In this case, the attending physician changes the course of treatment and prescribes other medications.

Overdose

Some people incorrectly use Andipal tablets to normalize blood pressure, causing them to overdose, which will only aggravate the situation and worsen their health. The main signs of an overdose of tablets include:

impaired coordination of movements;
problems with the performance of the gastrointestinal tract;
an allergic reaction, which is manifested by itching and redness of the skin on the extremities;
depression and apathy.

Also long-term treatment and overuse medications have a negative impact on circulatory system patient. Its performance deteriorates due to the influence of analgin, which is part of the drug.

To prevent the patient’s condition from worsening due to an overdose, it is recommended to determine the dosage of the medication before treatment. This should be done with your doctor, as only he can determine optimal dosage for every patient.

Special instructions

Before taking Andipal for high blood pressure, it is recommended that you read special instructions on its use.

You should not use tablets for long-term treatment high blood pressure. The drug is produced for children and adults only for temporary use to relieve blood pressure or headaches, which often bother patients.

If you use the medicine for more than ten days you will have to monitor peripheral picture blood and monitor liver health. Therefore, experts advise using Andipal for no longer than a week. If the medicine does not start working within three days, you will have to stop taking the pills and change the course of treatment.

When taking the drug, it should be taken into account that it belongs to narcotic analgesics. Because of this, doctors do not advise driving vehicles during treatment and 2–3 days after using the product. It is also not recommended to engage in activities that require a person to concentrate or have quick psychomotor reactions.

Drug interactions

Many people are interested in how to take Andipal when treating blood pressure in combination with other drugs and whether it is even possible to combine the medicine with others medicinal products. The drug can be taken in combination with other medications to improve the hypotensive effect on the body. To do this, take medications that are included in the following pharmacological groups:

Adrenergic blockers that help cope with heart or vascular diseases.
Diuretics, which help cleanse the kidneys and improve the removal of salts from the body.
Blockers used to prevent heart failure.
Antispasmodics that help get rid of spasms in the digestive canals, blood vessels and smooth muscles.

Due to the composition of the drug, it is not used with alcohol and drugs related to opioid analgesics. This contributes to the development of side effects.

Also, tablets cannot be combined with antacid medications and activated carbon, since this impairs the absorption of the drug several times.

Modern Russians often suffer from hypertension and headaches caused by spasms. How to take the pain reliever Andipal for migraines - instructions for use for patients different ages tells in detail. The drug is an antispasmodic with sedative effect, which does not treat the cause of the symptoms. Reviews indicate the effectiveness of this product. However, before starting treatment, it is important not only to consult with a specialist, but also to learn more about the medicine.

Andipal tablets

This tool is a combined drug that has an analgesic and hypotensive effect on the body. Due to the active components, Andipal provides an antispasmodic effect and dilation of blood vessels at high blood pressure. This medicine for hypertension is prescribed for early stages to lower blood pressure. The drug is produced in tablets of 10 pcs. One package usually contains 3 blisters with instructions for use.

Composition of Andipal

The effectiveness of this analgesic is explained by its composition. The active components per 1 tablet are presented in the table below:

Pharmacodynamics and pharmacokinetics

Andipal belongs to the group of narcotic analgesics. Using tablets according to instructions does not help treat arterial hypertension, but lowers blood pressure. Active components of this medicine relieve spasms of organs and peripheral vessels, lower the patient’s blood pressure. Metamizole sodium normalizes body temperature and relieves pain.

After entering the gastrointestinal tract, the drug is absorbed into the blood within a few minutes, blocks the prostaglandin system of arachidonic acid, and affects the sensitivity threshold of the hypothalamus (part of the brain). Papaverine hydrochloride reduces the tone of the smooth muscles of internal organs and has a vasodilating effect. Due to bendazole, the medicine restores peripheral nerve endings, stimulates spinal cord. Phenobarbital has a sedative effect. In addition, this component enhances the hypotensive effect.

Andipal's capabilities are presented below:

Eliminates headaches caused by vasospasm.
Removes pain syndrome for spasms of the intestines, stomach and other internal organs (but does not eliminate the cause of the symptom).
It has a hypotensive effect, but is not used to treat hypertension.

After administration, Andipal is quickly absorbed into the body through the stomach. Maximum absorption of the active components is achieved 20 minutes after application. Metabolized active substance in the liver. Excreted completely by the kidneys in the urine within long period time. For this reason, you should not exceed the dosage of the drug, so as not to worsen your condition.

Indications for use

This drug is prescribed to patients as an analgesic to relieve pain caused by vasospasm. This condition negatively affects blood circulation and flow to internal organs useful substances, so it’s worth taking Andipal. Below are the symptoms and diseases in which this drug effective:

eye pain;
dysuria;
essential hypertension (initial stage);
intracranial hypertension (benign);
diseases associated with high blood pressure;
hypertensive encephalopathy;
migraine;
pain in the chest while breathing;
pain in the abdomen, perineum, pelvis;
bladder tenesmus;
lesions of the trigeminal nerve;
sharp pain;
chronic headache after injury.

How to take Andipal

Reviews from patients and doctors confirm the hypotensive and antispasmodic effect of Andipal. Tablets are prescribed to all patients in individual dosages, taking into account the diagnosis and other factors. Standard instructions for use of the medicine:

For high blood pressure at the initial stage of hypertension, take 1 tablet to relieve symptoms.
For headaches, without the goal of lowering blood pressure, take 2 tablets a day with an interval of 60 minutes. The maximum daily dose of Andipal according to the instructions is 5 tablets.
For vegetative-vascular disorders (hypertensive type), Andipal is used 1 tablet 2 times a day. The duration of treatment is no more than 3 days in a row. It is recommended to combine the analgesic with the use of motherwort or valerian.

Special instructions

This remedy is not used for long-term treatment. Tablets are available for symptomatic use for certain patient conditions. In cases where the use of Andipal is intended for a period longer than 1 week, it is recommended to monitor the condition of the patient’s liver and peripheral blood picture. If the drug does not produce an effect within 3 days, then stop using the medication and consult a doctor to prescribe another treatment.

It is important to remember that Andipal tablets are narcotic analgesics. In this regard, during the period of treatment with this drug, it is recommended to refrain from driving a car and performing activities that require speed of psychomotor reactions and high concentration attention. In addition, the drug is addictive due to the presence of phenobarbital in the composition. Children and adolescents from 8 to 18 years old are allowed to take Andipal strictly as prescribed by a doctor.

Andipal during breastfeeding

For young mothers, especially before starting to use any medication, it is important to consult with specialists. According to the instructions, Andipal is not prescribed to patients during pregnancy and during breastfeeding. If it is impossible to do without this drug during lactation, the child is transferred to artificial feeding. The point is that active ingredients Andipala negatively affects the baby and spoils the quality of mother's milk.

Andipal and alcohol

Most medications should not be used in combination with alcoholic drinks. Andipal enhances the effect on the body ethyl alcohol, which is very dangerous for the patient. While intoxicated or after drinking small amount This drug should not be consumed in alcoholic beverages, even if indicated.

Drug interactions

The hypotensive effect of Andipal on the body increases significantly when the drug is combined with the following medications pharmacological groups:

Calcium channel blockers (Nifedipine).
Nitrates (Nitroglycerin).
Beta blockers (Anaprilin, Metoprolol).
Diuretics (Furosemide, Lasix and others).
Myotropic antispasmodics (Eufillin and others).

The hypotensive effect of the drug is reduced if its use is combined with the following types of drugs:

Tonic (ginseng in the form of tincture or tablets, Eleutherococcus, Rhodiola rosea).
M- and N-cholinomimetics (Acetylcholine, Nicotine).
Analeptics (Cytisine, Camphor, Sulphocamphocaine).
Adrenergic agonists (Ephedrine, Adrenaline).

According to the instructions for use, simultaneous use Andipala with drugs from the group of opioid analgesics provokes the development of side effects. The drug is less absorbed in gastrointestinal tract, if you combine it with activated carbon and various medications that provide an astringent effect and have an enveloping effect. The latter include antacid medications and preparations containing bismuth.

Side effects

According to the instructions for use, the drug can cause the following side symptoms:

constipation;
allergy;
nausea;
nephritis;
drowsiness;
red color of urine;
hyperhidrosis.

With prolonged use of Andipal, the following disorders may occur:

agranulocytosis;
thrombocytopenia;
leukopenia.

Overdose

During treatment, it is important to adhere to the instructions for use. Exceeding the dosage of the drug leads to such negative consequences, How:

dizziness;
lethargy;
drowsiness;
general weakness;
anaphylactic shock.

Contraindications

Andipal is an effective medicine, but specific. Before starting a course of therapy, it is important to read the instructions for use and consult with your doctor. Contraindications for the use of Andipal are: following states:

Liver problems.
Renal dysfunction.
Decreased muscle tone.
Systemic diseases blood.
Hypotension (the drug does not increase blood pressure, but lowers it).
Increased blood clotting.
Individual intolerance.
Pregnancy.
Lactation period.
Hereditary pathologies pigment metabolism.

Terms of sale and storage

Russians can purchase Andipal according to the instructions for use without a special prescription from a doctor. When storing medicine at home, you should adhere to the following rules:

The place should be dark, dry, inaccessible to children.
The air temperature should not exceed 30 °C.
Shelf life – up to 2.5 years.

Analogues

This product has no analogues in composition. However, you can buy it at the pharmacy effective medicine, similar to this drug in properties. The following drugs are analogues of Andipal for their antispasmodic effect:

Nomigren;
Urolesan;
Papazol-UBF;
Unispaz;
No-shpalgin;
Theodibaverin.

Andipal price

The cost of Andipal tablets depends on the chosen pharmacy, the manufacturer and other factors. Below is a table with an overview of prices for the drug:

Pharmacy name	Manufacturer
	Avexima, 20 pcs.
	Pharmstandard Tomskkhimpharm, 10 pcs.
"ZdravZona"
	JSC Pharmstandard-Tomskkhimpharm
	OJSC Irbit Chemical Pharmaceutical Plant
	LLC Anzhero-Sudzhensky Chemical Plant, 10 pcs.
Pharmacy "36.6"	Pharmstandard, 10 pcs.
Pharmacy "36.6"	Avexima, LLC Anzhero-Sudzhensky Chemical Plant