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Pentalgin green tablets. Active ingredients and dosage form

Today, pharmaceutical companies produce several varieties medicine Pentalgin - the composition of medications varies depending on the full name. The effectiveness of each drug is assessed according to the causes of pain.

Composition of Pentalgin tablets

The type of pain reliever in question is the only type that is available without a prescription. Its formula has recently been improved so as to eliminate pain not only due to inflammatory processes and nervous tension, but also due to vascular spasms.

New or green Pentalgin has a codeine-free composition and:

naproxen;
drotaverine;
paracetamol;
pheniramine maleate;
anhydrous caffeine.

The combination of these 5 components provides an antispasmodic, anti-inflammatory, analgesic and mild antipyretic effect.

It is important to note that the possibility of purchasing such Pentalgin over-the-counter does not exclude the need to consult with your doctor. The fact is that the ingredients of the medicine produce a lot of negative side effects, especially for the digestive and cardiovascular system. Moreover, the caffeine content in high concentration provokes an increase blood pressure, which is unacceptable for people suffering from hypertension.

Composition of Pentalgina Plus

This type of drug differs in the content of an additional analgesic – propyphenazone. This ingredient has low anti-inflammatory activity, but has pronounced analgesic and antipyretic properties. Combination with other components of the drug allows you to achieve maximum quick effect even with very severe pain.

Full composition:

codeine phosphate;
phenobarbital;
caffeine;
propyphenazone.

As a rule, the described type of Pentalgin is prescribed for diseases and injuries of joints, muscles, pinched nerves, toothache and headaches. It is sometimes used to relieve the symptoms of febrile syndrome.

Composition of the drug Pentalgin-ICN

The presented form of the line of analgesics refers to high-intensity painkillers. Combination of active chemical compounds provides stable and fast cupping pain syndrome even with chronic diseases cardiovascular and nervous system. Pentalgin-ICN successfully relieves clinical manifestations migraines, spasms smooth muscle.

The drug consists of the following ingredients:

metamizole sodium;
codeine phosphate;
paracetamol;
caffeine;
phenobarbital.

Like the previous version of Pentalgin, the medicine in question is dispensed only with a prescription written by a doctor.

Composition of Pentalgin N or Neo

Latest form medication produced without paracetamol. This Pentalgin has excellent antispasmodic and analgesic properties, but has less pronounced anti-inflammatory and antipyretic activity. This is achieved thanks to the inclusion of naproxen, a non-steroidal substance with high analgesic properties.

Pentalgin is a modern and very effective antispasmodic analgesic. It helps relieve pain of various origins, bring down the temperature during a cold and reduce the severity of inflammation.

Active ingredients and dosage form

The combined drug Pentalgin is produced in the form of tablets for oral administration. They contain non-steroidal anti-inflammatory components (and naproxen), a myotropic antispasmodic (drotaverine hydrochloride), a histamine and muscarinic receptor blocker (pheniramine maleate) as well as caffeine, which has psychostimulating and adaptogenic properties.

Light green tablets are supplied in blisters of 4, 6, 10 and 12 pieces.

Pentalgin: what do pills help with?

Pentalgin has analgesic, antispasmodic, anti-inflammatory and antipyretic properties.

Paracetamol blocks the enzyme cyclooxygenase in the central nervous system, and affects the centers of thermoregulation and pain, which determines its analgesic and antipyretic effect.

The NSAID naproxen reduces the activity of cyclooxygenase, thereby reducing the release of inflammatory mediators - prostaglandins.

Drotaverine helps relieve spasms of smooth muscle elements by suppressing the activity of the phosphodiesterase-4 enzyme.

Pheniramine has a mild sedative effect, reduces spasms and blocks specific histamine receptors. Under its influence, inflammatory exudation decreases.

Caffeine tones and dilates blood vessels and increases the bioavailability of other components.

A single dose for pain relief is 1 tablet, and the frequency of administration is 1-3 times a day.. Acceptable daily dose– 4 tablets. However, you should not use this drug for more than 5 days in a row. As an antipyretic (antipyretic) for colds, Pentalgin is taken for up to 3 days. If there is a need to continue treatment, you should consult your doctor.

Indications

Pentalgin is indicated for pain (including spastic origin) and increased temperature due to colds.

Contraindications

Pentalgin should not be taken by patients with the so-called. the “aspirin triad,” which includes salicylate intolerance and recurrent polyposis of the nose and nasal sinuses.

Other contraindications include:

individual hypersensitivity to active or auxiliary ingredients of drugs;
in the organs of the digestive system;
erosions and ulcers of the gastrointestinal tract (during exacerbation);
inhibition of hematopoiesis;
severe functional failure of the liver (including with and) and (or) kidneys;
carried out;
ventricular extrasystole;
spicy ;
high levels of potassium in the blood (hyperkalemia).

Pentalgin is not prescribed to children and adolescents under 18 years of age.

Pentalgin during pregnancy

Pentalgin is contraindicated for women during pregnancy and breastfeeding.. The active components of the drug are able to bypass the hematoplacental barrier and are found in breast milk. If treatment is necessary during lactation, the question is raised about temporarily transferring the baby to artificial feeding or replacing the drug with a safer one.

Side effects

As a hypersensitivity reaction develops, skin rashes () may appear and swelling may develop.

Possible side effects of Pentalgin:

If at least one of the listed symptoms develops, treatment with the drug should be stopped and the doctor should be informed about side effects.

Overdose

In case of an overdose, the liver can be seriously damaged (even hepatonecrosis, i.e., tissue death, cannot be ruled out). Signs appear 12-48 hours after taking a large dose of Pentalgin. Encephalopathy progresses against its background.

If the dose is significantly exceeded, the patient is impaired heart rate and kidney function, and the pancreas is affected.

Coma and death are possible.

In case of Pentalgin poisoning, you should call an ambulance, urgently perform a gastric lavage and give it to the victim.

An effective antidote for paracetamol is Acetylcysteine, but its use this drug makes sense only within 8 hours after poisoning.

If bleeding occurs in the gastrointestinal tract, the patient is advised to take antacids and additional gastric lavage with a cooled isotonic solution. For cupping epileptic seizures give an injection of Diazepam (iv). Overdose may cause depression respiratory function, therefore, additional oxygenation (the victim is given an oxygen cushion) and mechanical ventilation may be required. Intravenously administered saline solutions to normalize water and electrolyte balance.

Interaction with other medications

It is important to exclude the parallel use of Pentalgin with Rifampicin and drugs from the tricyclic and groups, since they increase the risk toxic damage liver. For the same reason, reception was excluded ethanol(incl. pharmaceutical tinctures alcohol based).

Paracetamol present in the combined drug potentiates the effect indirect anticoagulants , worsening blood clotting. Diflunisal increases the hepatotoxic effect of paracetamol by increasing its concentration in the serum by one and a half times.

Another active ingredient, naproxen, reduces the effectiveness of the diuretic. Furosemide and increases toxicity antibacterial agents from the group of sulfonamides. It also slows down the excretion of lithium.

The antispasmodic component drotaverine reduces the effectiveness of the remedy for - Levodopa.

Pheniramine has a depressant effect on the central nervous system in combination with sleeping pills And.

The biotransformation of caffeine in the body slows down when taken birth control pills,-fluoroquinolones Norfloxacin and Ciprofloxacin, as well as Medicines for treatment Disulfiram. Caffeine metabolism accelerates when taken in parallel anticonvulsants and antiepileptic drugs(in particular Primidone) and barbiturates.

Reception psychostimulants(including drinks containing caffeine) leads to excessive stimulation of the central nervous system (overexcitation and increased reflexes or, conversely, inhibition).

You should not take Pentalgin and others at the same time non-steroidal anti-inflammatory drugs(especially those containing paracetamol).

Additionally

Particular caution should be observed when prescribing Pentalgin to persons with the following pathologies:

Patients suffering from these diseases are strongly recommended to consult with their doctor before starting treatment.

If symptomatic treatment lasts more than 5-7 days, monitoring of liver function indicators is required. Analysis is also needed peripheral blood(UAC).

Alcohol intake should be avoided during treatment!

Patients taking Pentalgin should be careful when administering vehicles. It is advisable to temporarily refrain from working with potentially dangerous mechanisms, since the ability to concentrate may be reduced.

Table of contents: Active components And dosage form Pentalgin: what do pills help with? Recommended dosages Indications Contraindications Pentalgin during pregnancy Side effects Overdose Interaction with others medicines Additionally, conditions for storage and dispensing from pharmacies Pentalgin analogues

Active ingredients and dosage form

The combined drug Pentalgin is produced in the form of tablets for oral administration. They contain non-steroidal anti-inflammatory components (paracetamol and naproxen), a myotropic antispasmodic (drotaverine hydrochloride), a histamine and muscarinic receptor blocker (pheniramine maleate) as well as caffeine, which has psychostimulating and adaptogenic properties.

Light green tablets are supplied in blisters of 4, 6, 10 and 12 pieces.

Pentalgin: what do pills help with?

Pentalgin has analgesic, antispasmodic, anti-inflammatory and antipyretic properties.

Paracetamol blocks the enzyme cyclooxygenase in the central nervous system, and affects the centers of thermoregulation and pain, which determines its analgesic and antipyretic effect.

The NSAID naproxen reduces the activity of cyclooxygenase, thereby reducing the release of inflammatory mediators - prostaglandins.

Drotaverine helps relieve spasms of smooth muscle elements by suppressing the activity of the phosphodiesterase-4 enzyme.

Pheniramine has a mild sedative effect, reduces spasms and blocks specific histamine receptors. Under its influence, inflammatory exudation decreases.

Caffeine tones and dilates blood vessels and increases the bioavailability of other components.

A single dose for pain relief is 1 tablet, and the frequency of administration is 1-3 times a day.. Permissible daily dose – 4 tablets. As an analgesic, this drug should not be used for more than 5 days in a row. As an antipyretic (antipyretic) for colds, Pentalgin is taken for up to 3 days. If there is a need to continue treatment, you should consult your doctor.

Indications

Pentalgin is indicated for pain (including spastic origin) and increased temperature due to colds.

myalgia;
arthralgia;
neuralgia;
radiculitis;
painful periods;
background pain chronic inflammation gallbladder (including calculous cholecystitis);
renal colic;
postoperative pain syndrome;
toothache due to pulpitis and periodontitis;
colds with a feverish reaction.

Contraindications

Pentalgin should not be taken by patients with the so-called. “aspirin triad”, which includes salicylate intolerance, bronchial asthma and recurrent polyposis of the nose and nasal sinuses.

Other contraindications include:

individual hypersensitivity to active or auxiliary ingredients of drugs;
bleeding in the organs of the digestive system;
erosions and ulcers of the gastrointestinal tract (during exacerbation);
inhibition of hematopoiesis;
severe functional failure of the liver (including with cirrhosis and hepatitis) and (or) kidneys;
performed coronary artery bypass grafting;
hypertension;
ventricular extrasystole;
acute heart attack;
high levels of potassium in the blood (hyperkalemia).

Pentalgin is not prescribed to children and adolescents under 18 years of age.

Pentalgin during pregnancy

Pentalgin is contraindicated for women during pregnancy and breastfeeding.. The active components of the drug are able to bypass the hematoplacental barrier and are found in breast milk. If treatment is necessary during lactation, the question of temporarily transferring the baby to artificial feeding or replacing the drug with a safer one is raised.

Side effects

With the development of a hypersensitivity reaction, skin rashes (urticaria) may appear and Quincke's edema may develop.

Possible side effects of Pentalgin:

inhibition of hematopoiesis (manifested by anemia, thrombocytopenia and leukopenia);
arterial hypertension (high blood pressure);
heart rhythm disturbances;
heartbeat;
tachycardia;
psycho-emotional arousal;
unmotivated feeling of anxiety;
hyperreflexia;
shiver;
dizziness;
headache;
insomnia;
impaired ability to concentrate;
dyspeptic disorders;
damage to the mucous membranes of the digestive organs (erosions and ulcers);
decreased functional activity of the liver and (or) kidneys;
pain in the abdominal area;
tinnitus;
decreased acuity of auditory perception;
rapid breathing;
skin inflammatory reactions (dermatitis).

If at least one of the listed symptoms develops, treatment with the drug should be stopped and the doctor should be informed about side effects.

Overdose

In case of an overdose, the liver can be seriously damaged (even hepatonecrosis, i.e., tissue death, cannot be ruled out). Signs liver failure appear 12-48 hours after taking a large dose of Pentalgin. Encephalopathy progresses against its background.

If the dose is significantly exceeded, the patient’s heart rhythm and kidney function are disrupted, and the pancreas is affected.

Coma and death are possible.

In case of Pentalgin poisoning, you should call an ambulance, urgently perform gastric lavage and give the victim enterosorbents.

An effective antidote for paracetamol is Acetylcysteine, but the use of this drug makes sense only within 8 hours after poisoning.

If bleeding occurs in the gastrointestinal tract, the patient is advised to take antacids and additional gastric lavage with a cooled isotonic solution. To stop epileptic seizures, an injection of Diazepam (iv) is given. Against the background of an overdose, respiratory function may be depressed, so additional oxygenation (the victim is given an oxygen cushion) and mechanical ventilation may be required. Saline solutions are administered intravenously to normalize water and electrolyte balance.

Interaction with other medications

It is important to exclude the parallel use of Pentalgin with Rifampicin and drugs from the groups of tricyclic antidepressants and barbiturates, since they increase the risk of toxic liver damage. For the same reason, reception was excluded ethanol(including alcohol-based pharmaceutical tinctures).

Paracetamol present in the combined drug potentiates the effect indirect anticoagulants, worsening blood clotting. Diflunisal increases the hepatotoxic effect of paracetamol by increasing its concentration in the serum by one and a half times.

Another active ingredient, naproxen, reduces the effectiveness of the diuretic. Furosemide and increases the toxicity of antibacterial agents from the sulfonamide group. It also slows down the excretion of lithium.

The antispasmodic component drotaverine reduces the effectiveness of the drug for Parkinson's disease - Levodopa.

Pheniramine has a depressant effect on the central nervous system in combination with sleeping pills and tranquilizers.

The biotransformation of caffeine in the body slows down when taken birth control pills, fluoroquinolone antibiotics Norfloxacin and Ciprofloxacin, as well as Medicines for the treatment of alcoholism Disulfiram. Caffeine metabolism accelerates when taken in parallel anticonvulsants and antiepileptic drugs(in particular Primidone) and barbiturates.

Reception psychostimulants(including drinks containing caffeine) leads to excessive stimulation of the central nervous system (overexcitation and increased reflexes or, conversely, inhibition).

You should not take Pentalgin and others at the same time non-steroidal anti-inflammatory drugs(especially those containing paracetamol).

Additionally

Particular caution should be observed when prescribing Pentalgin to persons with the following pathologies:

cerebral vascular lesions;
hepatitis (viral and alcoholic);
epilepsy;
angle-closure glaucoma;
peripheral arterial disease;
benign hyperbilirubinemia.

Patients suffering from these diseases are strongly recommended to consult with their doctor before starting treatment.

If symptomatic treatment continues for more than 5-7 days, monitoring of liver function tests is required. A peripheral blood test (PBC) is also required.

Alcohol intake should be avoided during treatment!

Patients taking Pentalgin should be careful when driving. It is advisable to temporarily refrain from working with potentially dangerous mechanisms, since the ability to concentrate may be reduced.

Caution when taking Pentalgin should be observed in elderly and senile patients.

Conditions for storage and release from pharmacies

A doctor's prescription is not required to purchase Pentalgin.

Tablets should be kept in places protected from sun rays at a temperature of no more than +25°C.

Keep away from children!

The shelf life of the drug is 2 years from the date of release (marked on the packaging). Do not use after expiration date!

Analogues of Pentalgin

Analogs of the drug Pentalgin are:

Sedal-M;
Pentamyalgin;
Spazgan;
Pentalfen;
Efferalgan;
Sedalgin-Neo.

Plisov Vladimir, doctor, medical observer

Introducing New Pentalgin®- an analgesic with analgesic, anti-inflammatory and antispasmodic effects!

The combination of active components in the new Pentalgin makes it possible to reduce their dose, which improves the safety profile of the drug.

An absolute innovation of the new Pentalgin is the introduction of drotaverine into the antispasmodic composition, which expands the range of use of the drug and enhances its effect in pain syndrome associated with spasm of smooth muscles.

New Pentalgin is produced in accordance with European standards quality.

New Pentalgin does not contain codeine and is available without a prescription.

New Pentalgin is available in several forms - 4, 12 and 24 tablets (the concept of “to go”, “to work”, “for home”).

Indications for use

Pain syndrome of various origins, including pain in joints, muscles, radiculitis, menstrual pain, neuralgia, dental pain and headaches (including headaches caused by cerebral vasospasm). Pain syndrome associated with spasm of smooth muscles, including chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic. Post-traumatic and postoperative pain syndrome, including those accompanied by inflammation. Colds accompanied by fever (as symptomatic therapy).

Question-Answer

You produce several drugs called Pentalgin. Please explain how they differ and how to choose which drug is better to take?

The Pharmstandard company produces several drugs called Pentalgin, but they differ in full name"Pentalgin-N", "Pentalgin-ICN", "Pentalgin Plus" and "Pentalgin". Currently full description drug compositions are presented on the company’s website.

These drugs have different compositions of active ingredients, different shapes and the color of the tablets. All drugs contain 5 components, and the main indication for their use is pain of various origins.

Because sensitivity to pain medications different classes each person is individual, the presence of several drugs in the Pentalgin line allows you to choose the most suitable analgesic for each consumer.

The table below contains a comparative description of the compositions of the drugs in the Pentalgin line.

paracetamol 325 mg	paracetamol 300 mg	naproxen 100 mg	paracetamol 300 mg
naproxen 100 mg	propyphenazone 250 mg	metamizole sodium 300 mg	metamizole sodium 300 mg
caffeine anhydrous 50 mg	caffeine 50 mg	caffeine 50 mg	caffeine 50 mg
drotaverine HCl 40 mg	codeine phosphate 8 mg	codeine 8 mg	codeine phosphate 8 mg
pheniramine maleate 10 mg	phenobarbital 10 mg	phenobarbital 10 mg	phenobarbital 10 mg

Which Pentalgin is most effective for headaches?

All drugs in the Pentalgin line are intended to relieve pain of various origins, including headaches. Due to the fact that headaches can be caused by for various reasons, it is impossible to determine it yourself and decide in advance which painkiller will be the most effective. It may be optimal to choose a drug that affects different possible reasons occurrence of headache. Therefore, the drugs in the Pentalgin line contain different components with different mechanisms of action. The “new” Pentalgin contains drotaverine, which has an antispasmodic effect and therefore can be used for headaches caused by cerebral vasospasm. If you experience headaches regularly, you should consult a specialist to conduct an examination and determine the exact cause of the headache.

Can children and adolescents take Pentalgin?

The drugs Pentalgin-N, Pentalgin Plus and Pentalgin-ICN are approved for use in adults and children over 12 years of age, Pentalgin is approved for use only in adults (over 18 years of age), because There have been no studies of the effectiveness and safety of the drug in childhood and adolescence.

Please explain, are Pentalgins now available with or without a prescription?

Currently, only Pentalgin, coated tablets are available over-the-counter film-coated. It contains paracetamol, naproxen, caffeine, drotaverine and pheniramine. The drugs Pentalgin-N, Pentalgin-ICN, Pentalgin-plus are available with a doctor's prescription.

Pentalgin-N and Pentalgin-ICN contain phenobarbital and codeine - can this affect the results of blood and urine tests when determining the content of narcotic substances in the blood (for example, if you suspect driving under the influence of drugs)?

Pentalgin-N contains analgin (metamizole sodium), naproxen, caffeine, phenobarbital and codeine. The elimination period for half the dose of the Pentalgin N phenobarbital component, according to literature sources, is 3-4 days, so trace amounts of barbiturates (phenobarbital) can remain in the body sometimes up to 2-3 weeks, even after a single dose of any drug containing phenobarbital.

Therefore, the instructions for use of Pentalgin N and Pentalgin-ICN indicate that when taking the drug it is recommended to refrain from potentially dangerous species activities that require increased attention and speed of psychomotor reactions, which include driving vehicles. The period of abstinence from driving depends on the individual reaction and the speed of removal of components from the patient’s body. The ability to drive and the presence of signs of intoxication can only be assessed through a medical examination.

In which part of the gastrointestinal tract do Pentalgin tablets dissolve? And can they be used to relieve stomach pain?

Pentalgin tablets are film-coated, which dissolves no more than 30 minutes after administration - i.e. dissolution occurs in the stomach. However, the drug Pentalgin is not intended to relieve stomach pain.

Indications for taking Pentalgin include:

Pain syndrome of various origins, including pain in the joints, muscles, radiculitis, menstrual pain, neuralgia, dental pain and headaches (including headaches caused by cerebral vasospasm).
Pain syndrome associated with spasm of smooth muscles, including chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic.
Post-traumatic and postoperative pain syndrome, including those accompanied by inflammation.
Colds accompanied by fever (as symptomatic therapy).

To relieve stomach pain, special medications are used, the choice of which depends on accurate diagnosis.
We recommend that you contact a gastroenterologist for examination, diagnosis and decision on the need for this or that therapy.

How long can you continuously take Pentalgin preparations containing codeine?

According to approved instructions for medical use, the drugs Pentalgin-N, Pentalgin Plus and Pentalgin-ICN should not be taken for more than 5 days as an analgesic and for more than 3 days as an antipyretic without a doctor’s prescription.

Is it possible to take Pentalgin while breastfeeding a baby?

Taking the drug Pentalgin during lactation is contraindicated, the release of drug components from breast milk and their effect on the child has not been studied. If it is necessary to use the drug during lactation, you must stop breastfeeding.

The most purchased drugs in all pharmacies are painkillers. Moreover, people often choose them without consulting a doctor. Some medications are more popular, others are purchased less frequently. What does this depend on? People are influenced primarily by recommendations from friends, own experience, as well as the price. Many patients are accustomed to Pentalgin. Having tried the drug once, they buy only it to relieve pain. But in recent years are increasingly looking for more cheap replacement usual medications. Therefore, pharmacies ask what analogue of Pentalgin is available. People are interested in cheaper, but the same effective medicine. Moreover, after the ban on codeine, Pentalgin became less effective.

Generic and analogue: what is it?

To put a drug on the market, you need a patent for it. Its design, creation of original packaging - all this costs a lot of money. Therefore, branded drugs are quite expensive. But after 20 years, in most cases, the patent expires, and others pharmaceutical companies can release similar drugs. Such drugs are called analogues or generics. They usually cost less but have the same active substance, so they have the same effect. Thus, several drugs with the same composition, but different in price, appear on sale. Some patients know about this and try to buy cheaper analogues instead of original drugs. In most cases, they are just as effective, but sometimes it happens that the quality of the components included in them is lower. Many patients try to find an analogue of Pentalgin. This drug relieves any pain so effectively that for some, nothing else helps.

What is Pentalgin from?

These tablets are used for pain of various origins:

Arthritis, osteochondrosis, myalgia and radiculitis;

For headaches, even those caused by vasospasm;

For toothache;

The drug is effective for post-traumatic or postoperative syndrome;

Quickly relieves renal colic, pain due to cholecystitis, pancreatitis or cholelithiasis;

Pentalgin is used to alleviate symptoms of ARVI and influenza: it slightly reduces the temperature and relieves pain.

Features of composition and action

How can one explain this effectiveness of the drug? Only by its unique composition. It contains five active components, which is reflected in the name itself. Initially the drug contained two narcotic substances: codeine and phenobarbital. Because of them, the analgesic effect was more powerful. Of the analgesics, it contained metamizole sodium. But now “Pentalgin” is produced with the following composition:

Paracetamol, which affects pain and thermoregulation centers in the brain;

Naproxen is a strong non-steroidal anti-inflammatory drug;

Caffeine - dilates the blood vessels of the heart and kidneys, eliminates drowsiness and fatigue, and increases the absorption of analgesics;

Drotaverine is a strong antispasmodic;

Pheniramine maleate - has antispasmodic, antihistamine and mild sedative effects.

Not all patients who are looking for an analogue of Pentalgin know that its composition has changed. Now the drug with metamizole sodium, phenobarbital and codeine can only be purchased with a prescription, and even then not everywhere.

How to replace Pentalgin

There are a lot of painkillers in pharmacies. But “Pentalgin” stands out among them. There are cheaper analogues, but not all of them are as effective. When choosing a medicine to replace Pentalgin, you should definitely consult with your doctor and carefully study the instructions. You also need to know that other drugs will not necessarily be effective, even with the same composition as Pentalgin. A replacement - analogues and generics of this medicine - may be as follows:

"Pentalfen" - drug Russian production, but is available by prescription as it contains narcotic analgesics.
“Pentamyalgin” also contains phenobarbital and codeine and is not much cheaper than the original.
“Plivalgin” is cheaper than the original, but its composition is slightly different: along with paracetamol, it contains the analgesic propyphenazone.
The drug "Sedal M" has similar composition with the original “Pentalgin” and costs no less than it.
Bulgarian-made Sedalgin Plus is slightly less effective, since it does not contain antispasmodics.

In addition, there are several drugs that can also replace Pentalgin. Analogs that are cheaper are Spazgan, Ibuprofen, Drotaverine, Paracetamol, Novigan, Solpadeine and others. These medications are more likely to be synonymous with Pentalgin, because they have a slightly different composition, but a similar effect.

Russian analogues of the drug

In recent years, the price of imported medicines has increased greatly. And in these conditions, the question became relevant: is there Russian analogue"Pentalgina". In our country, several drugs are produced, which contain five active ingredients.

1. "Pentamialgin" is complete analogue"Pentalgina" with codeine and phenobarbital. Therefore, it can only be purchased with a doctor's prescription. And the price for this drug is not small - about 130 rubles.

2. A similar drug produced in Russia is Pentalfen. Its composition and indications are the same, but it is almost impossible to find in pharmacies.

3. Another Russian analogue of Pentalgin in tablets is Santotitralgin. It is inexpensive - about 40 rubles, but the content of codeine and phenobarbital in its composition makes it inaccessible to many patients.

4. But perhaps the most popular Russian substitute"Pentalgina" is "Citramon". Its effect is a little weaker, but it costs less - 30-40 rubles. Its constituents, caffeine and aspirin, not only relieve pain, but also reduce fever and increase performance.

The cheapest analogues of "Pentalgin"

1. “Andipal” is close in composition to “Pentalgin”. It also contains an analgesic, antispasmodic and phenobarbital, which enhances their effect. You can buy “Andipal” for 40-50 rubles.

2. Another cheap analogue of Pentalgin is Spazgan. It contains two antispasmodics and metamizole sodium. Therefore, it is very effective for spasms, colic and migraines. You can purchase the drug for 40 rubles.

3. A drug very close in composition to Pentalgin is Caffetin. It also contains paracetamol, caffeine and an antispasmodic and is effective for vascular spasms, colic and other pain. The drug costs a little less than Pentalgin - about 80 rubles.

4. Those who are looking for a cheap analogue of Pentalgin should pay attention to such drugs as:

"Paracetamol" - price about 20 rubles,
"Drotaverine" - about 50 rubles,
“Ibuprofen” - 30 rubles.

These drugs are not complex; they contain one active ingredient. But in most cases, with pain of moderate intensity, they help.

How to choose the right analogue

Of course, many of those who often suffer from pain are looking for cheaper drugs. But when choosing analogues, you need to know that they may differ only in composition, but also in the amount of active ingredient. Even drugs containing the same components as Pentalgin may not be as effective. This depends on the degree of purification of the active substances and their concentration. Therefore, Pentalgin analogues may be poorly absorbed, have more side effects, or may not have any effect at all. desired effect. First of all, when choosing a medicine, you need to consult a doctor. Usually a specialist can offer several options that differ in cost. It rarely happens that only Pentalgin can relieve pain. Usually its cheaper counterparts are just as effective. But you should always carefully study the instructions and take the medicine in a small dose for the first time. In addition, you need to know the cause of the pain and use specific medications:

for migraines - “Migrenol”,
for colic - “No-Shpu” or “Drotaverine”,
when the temperature rises - Aspirin or Paracetamol.

There are currently many new drugs available. Some of them are dispensed by pharmacies without a doctor's prescription, others - strictly by prescription. It is useful for people to know what Pentalgin tablets are - instructions for use, how the medicine works, in what cases it helps, whether it can be given to children, what warnings there are.

What is Pentalgin

The release form of the drug is in the form of tablets. In the photo, Pentalgin tablets are capsules coated with a green, embossed shell. The cut of the tablets is green, sometimes with white splashes. Pentalgin is packaged in blister packs of 2, 4, 12 tablets. Outer packaging – carton. You can buy Pentalgin in a pharmacy without a doctor's prescription. The shelf life of the tablets is two years from the date of manufacture; the medicine must be stored in a dry, unlit place.

What does Pentalgin help with?

The drug has a combined pharmacological effect: analgesic; antipyretic (lowers temperature, relieves inflammation); antispasmodic effect. Pentalgin helps eliminate pain of various natures:

in joints, muscles;
dental, headache;
with spasm of smooth muscles internal organs;
postoperative, caused by inflammation;
symptomatic with feverish conditions during a cold.

For toothache

Good result is achieved when Pentalgin is used for toothache. The drug thanks to the combined pharmacological action simultaneously relieves pain and fights the inflammatory process of pulpitis. The effect is achieved half an hour after taking the medicine, but if the medicine does not help, the dose should not be increased. It is necessary to see a dentist for treatment of inflammation.

For headaches

The drug is an analgesic. Doctors recommend using Pentalgin for headaches. For migraines, the drug has the ability to dilate blood vessels, which helps improve blood supply to the brain and the patient’s well-being. The effect of pain relief is increased by blocking receptors with the drug pain, so Pentalgin received positive reviews in the fight against headaches.

During menstruation

The occurrence of pain in the lower abdomen during algodismenorrhea (menstruation) is associated with excessive synthesis of prostaglandins: they cause contraction of the uterus and spasm of the pelvic vessels. Due to stagnation of blood, tissues do not receive enough oxygen, and this is the cause of excitation pain receptors. Pentalgin for pain during menstruation relieves pain by regulating the synthesis of prostaglandins, reducing the frequency of uterine muscle contractions and by blocking pain receptors.

From temperature

The use of Pentalgin for colds is effective. It helps eliminate all symptoms of flu and sore throat: normalize temperature, fight inflammation in the body and relieve pain during feverish conditions. Combined action The drug is the reason that doctors often prescribe Pentalgin for fever.

Instructions for use of Pentalgin

The medicine is produced by the manufacturer with annotation on its use. Instructions for use of the drug Pentalgin contain:

description pharmacological properties;
information about the active and auxiliary substances that are part of the drug;
a list of patient conditions when the drug can be used;
a warning about side effects that may occur when using the drug;
contraindications for use.

Compound

The combined effect of Pentalgin is due to the properties of five active substances. The composition of Pentalgin tablets depends on the type of drug. The manufacturer produces the drug with four names: this allows you to select the appropriate drug for a person’s individual sensitivity to analgesics. Pentalgin of all four varieties necessarily includes paracetamol.

It begins to relieve pain, affecting the centers of thermoregulation and pain, and relieves spasms. Together with the analgesic, it has an anti-inflammatory and antipyretic effect. In combination with paracetamol, the manufacturer uses other active substances. Pentalgin additionally contains four substances, the names of which are indicated in the instructions. The active elements of the drug together with paracetamol may be:

Naproxen. This non-steroidal substance regulates the synthesis of prostaglandins, which are responsible for muscle contraction. It relieves spasm, inflammation, and lowers temperature.
Caffeine. It has the ability to dilate blood vessels, increases brain activity, relieves signs of fatigue, drowsiness, and increases the effect of other painkillers.
Drotaverine hydrochloride. Relieves spasm smooth muscles genitourinary system, gastrointestinal tract, biliary tract, blood vessels.
Pheniramine maleate. It blocks the synthesis of histamine, has a sedative effect, and fights inflammatory processes. The substance relieves spasms, increases the effect of paracetamol and naproxen.
Propyphenazone.
Codeine. It is a narcotic element. Affects opioid receptors and changes the perception of pain. Reduces the degree of excitation of the center responsible for coughing, enhances the effect of anti-inflammatory and sedative substances. Long-term use may cause drug addiction.
Phenobarbital. Refers to barbiturates, increases the analgesic effect of paracetamol and metamizole.
Metamizole sodium. Non-steroidal drug, has an analgesic effect.

Indications for use

The instructions for the medicine contain recommendations on when the tablets can be taken. Indications for use of Pentalgin are as follows:

for pain in muscles and bones caused by arthralgia, myalgia, neuralgia, algodismenorrhea, migraine, ankylosing spondylitis, radiculitis, rheumatoid arthritis, spina bifida;
for pain caused by spasm, for diseases: chronic cholecystitis, cholelithiasis, renal colic;
after surgery, if pain and inflammation occur;
with chills, high temperature, inflammatory process for colds.

Dosage

How to take Pentalgin? The instructions contain limit standards taking the medicine. The dosage of Pentalgin is one tablet half an hour before or after a meal with consumption large quantity water, daily norm– three tablets, in special cases four. It is necessary to maintain an interval of four hours between doses of the medicine. When using the drug to normalize the temperature, the course of treatment is three days; for pain relief, it is not recommended to use tablets for longer than five days. The duration of treatment and the number of appointments are determined by the doctor.

Side effects

The instructions warn that there is a risk of a reaction to the use of the drug from internal organs and systems. Side effects Pentalgin can be as follows:

allergic manifestations in the form skin itching, rashes, urticaria;
changes in blood composition, anemia;
increased heart rate, arrhythmia, increased blood pressure;
dizziness, increased agitation, anxiety, sleep disturbance, decreased attention;
pain in the stomach, diarrhea, nausea, constipation, vomiting, loss of appetite;
decreased hearing, visual acuity, tinnitus;
disruption of the liver and kidneys.

Contraindications

People should not take the medicine on their own, because there are contraindications to the use of Pentalgin:

increased sensitivity, allergies to active substances;
pregnancy;
lactation period with breastfeeding child;
children under 12 years of age;
gastrointestinal bleeding;
serious violations kidney function, renal failure;
paroxysmal tachycardia;
hypertension;
diabetes mellitus;
inhibition of bone marrow hematopoiesis;
respiratory depression, asthma;
myocardial infarction.

It is not recommended to use tablets while taking other medications, because in combination with other active substances The toxicity of the drug may increase or the effect of the drug may decrease. It is forbidden to use Pentalgin and alcohol; you cannot take pills while driving, because they reduce attention. Pentalgin should be taken with caution by older people, patients viral hepatitis, alcoholic liver damage, with epilepsy.

In this medical article you can read: medicine Pentalgin. The instructions for use will explain in what cases the tablets can be taken, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Pentalgin, from which you can find out whether the medicine helped in the treatment of headaches, toothaches and fever in adults and children, for which it is also prescribed. The instructions list analogues of Pentalgin, prices of the drug in pharmacies, as well as its use during pregnancy. Describes the conditions for over-the-counter and prescription depending on the presence of components prohibited for general sale.

Anti-inflammatory and antispasmodic drug - Pentalgin. Instructions for use suggest taking N, ICN, Plus, green tablets without codeine for pain syndromes of various origins and colds accompanied by fever.

Release form and composition

The drug Pentalgin is available in the form of tablets (green over-the-counter) for oral administration, covered with a green protective film shell. On one side of the tablet there is an inscription in Latin letters(name of the drug). The tablets are packaged in contour cell shells of 2, 6, 10 and 12 pieces in a cardboard box; instructions with a detailed description are attached to the drug.

They also produce tablets (H, ICN, Plus).

The tablets contain:

Paracetamol + Naproxen + Caffeine + Drotaverine hydrochloride + Pheniramine maleate + excipients(tablets are green, do not contain codeine and are sold without a prescription).
Paracetamol + Metamizole sodium + Caffeine + Phenobarbital + Codeine phosphate + excipients (Pentalgin ICN).
Metamizole sodium + Naproxen + Caffeine + Phenobarbital + Codeine (in phosphate form) + excipients (Pentalgin N).
Paracetamol + Propyphenazone + Caffeine + Codeine phosphate + Phenobarbital + excipients (Pentalgin Plus).

Pharmacological action

Pentalgin has analgesic, antispasmodic, anti-inflammatory, and antipyretic effects. The therapeutic effect of the drug is due to the properties of the active substances that are part of the drug:

Paracetamol has an antipyretic and analgesic effect, which is due to the blockade of COX in the central nervous system, as well as an inhibitory effect on the centers of pain and thermoregulation.

Caffeine, which is part of Pentalgin, causes dilation of the blood vessels of skeletal muscles, heart and kidneys, tones the blood vessels of the brain and eliminates drowsiness. In addition, caffeine increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, which enhances the therapeutic effect of the drug.

Drotaverine has an effect on the smooth muscles of the gastrointestinal tract, genitourinary system, blood vessels and biliary tract.

Naproxen is pharmacological substance, which refers to non-steroidal anti-inflammatory drugs. This component has a pronounced antipyretic, anti-inflammatory and analgesic effect, which is associated with the normalization of prostaglandin synthesis.

Pheniramine has antispasmodic and mild sedative activity, and also enhances the analgesic effect of naproxen and paracetamol. Since some active ingredients penetrate the placental barrier, it is not advisable to use Pentalgin during pregnancy.

Indications for use

What does Pentalgin help with? The tablets have the following readings for use:

colds with fever;
various types of pain syndromes, for example, radiculitis, articular, muscle pain, during menstruation, neuralgia, algomenorrhea;
post-traumatic and postoperative pain, including with inflammatory phenomena;
pain due to spasm of smooth muscles caused by chronic cholecystitis, cholelithiasis, renal colic, postcholecystectomy syndrome.

The drug is also used as a cure for toothache and migraines.

Instructions for use

Pentalgin tablets are intended for oral use. Adult patients are prescribed 1 tablet 1 to 3 times a day, depending on the indications and severity of pain. An adult can take no more than 4 tablets per day, and the interval between doses should be at least 6 hours.

The duration of the course of drug therapy is determined by the doctor depending on the indications, however, it is not recommended to take the tablets for more than 3 days, since in this case the risk of developing side effects and drug ulcers increases.

IN in some cases Treatment with the drug can be continued for up to 5 days with the permission of a doctor and under his supervision. In the absence therapeutic effect During treatment with Pentalgin tablets, during the first 24 hours the patient should consult a specialist to clarify the diagnosis and select another remedy.

Contraindications

severe renal failure;
severe arterial hypertension;
children's and adolescence up to 18 years old;
lactation period (breastfeeding);
complete or incomplete combination bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance acetylsalicylic acid or other NSAIDs (including in history);
condition after coronary artery bypass surgery;
frequent ventricular extrasystole;
glaucoma;
hyperkalemia;
severe liver failure;
erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
anemia, leukopenia;
heavy organic diseases cardiovascular system (including acute myocardial infarction);
inhibition of bone marrow hematopoiesis;
hypersensitivity to the components of the drug;
deficiency of glucose-6-phosphate dehydrogenase;
pregnancy;
alcohol intoxication;
paroxysmal tachycardia;
gastrointestinal bleeding.

Side effects

When treated with Pentalgin, they may develop unwanted effects, For example, allergic reactions, disorders of the nervous, cardiovascular, digestive, genitourinary and hematopoietic systems, as well as sensory organs.

This may be accompanied by symptoms such as:

anxiety, tremor;
pain, erosive and ulcerative disorders of the gastrointestinal tract;
increased blood pressure;
abnormalities in kidney function;
dizziness;
methemoglobinemia, agitation;
itching, skin rash;
nausea, vomiting;
constipation;
irregular heartbeat, arrhythmia;
thrombocytopenia, agranulocytosis;
hearing loss;
sleep problems;
urticaria, angioedema;
leukopenia, anemia;
headache.

Children, pregnancy and breastfeeding

Contraindicated during pregnancy and lactation. Contraindicated for children under 18 years of age.

Special instructions

Pentalgin should not be prescribed with other drugs based on paracetamol or containing NSAIDs, drugs to relieve symptoms of colds, flu and nasal congestion. Taking the drug for more than 5-7 days requires monitoring peripheral blood counts and liver function.

Paracetamol interferes with glucose test results and uric acid in blood plasma. If determination of 17-ketosteroids is required, Pentalgin is discontinued 48 hours before the test. It should be borne in mind that naproxen increases bleeding time.

The influence of caffeine in the drug can have both an exciting and inhibitory effect on the central nervous system. You should not drink alcohol during treatment. You should be careful when driving vehicles.

Drug interactions

Barbiturates received by the patient for a long time reduce the effectiveness of paracetamol. Diflunisal increases the plasma concentration of paracetamol by 50%, resulting in an increased risk of developing hepatotoxicity. Paracetamol reduces the effect of uricosuric drugs and enhances the effect of indirect anticoagulants.

Oral contraceptives, disulfiram, cimetidine, norfloxacin and ciprofloxacin reduce the metabolism of caffeine in the liver, thereby slowing down its elimination and increasing its concentration in the blood.

Drotaverine, which is part of Pentalgin, may weaken the antiparkinsonian effect of levodopa.

Hydantoin-derived anticonvulsants (especially phenytoin), barbiturates, and primidone may increase the metabolism and clearance of caffeine.

With the simultaneous use of other drugs that stimulate the central nervous system, or drinking caffeine-containing drinks may cause excessive stimulation of the central nervous system.

Pheniramine - one of the active ingredients of Pentalgin - when interacting with ethanol, monoamine oxidase inhibitors, tranquilizers and sleeping pills enhances the inhibitory effect on the central nervous system.

Concomitant use of ethanol, tricyclic antidepressants, barbiturates or rifampicin increases the risk of liver toxicity, so such combinations should be avoided.

Another active ingredient in Pentalgin, naproxen, can reduce the diuretic effect of furosemide, enhance the effect of indirect anticoagulants, increase the toxicity of methotrexate and sulfonamides, reduce the excretion of lithium and increase its concentration in the blood plasma.

Ethanol taken during treatment with Pentalgin increases the risk of developing acute pancreatitis. Inhibitors of microsomal oxidation (for example, cimetidine) reduce the likelihood of hepatotoxicity of paracetamol.

Analogues of the drug Pentalgin

Paracetamol.
Ibuprofen.
Plivalgin.
Pentalgin Plus.
Pentalffen.
Pentamialgin.
Analgin.
Cardiomagnyl.
Sedalgin.
Amizon.
Pentalgin FS.

Vacation conditions and price

The average cost of Pentalgin (tablets No. 4) in Moscow is 90 rubles. Green tablets can be purchased at pharmacies without a prescription. Other forms are according to the recipe.

Tablets should be kept in a cool, dark place out of the reach of children. The expiration date is indicated on the packaging; do not use the drug after this period has expired.