Angina

Nice gel instructions for use. Components, release form

Inflammatory formations on the skin require the use of special preparations for external use. The action of such products is aimed at reducing unpleasant symptoms and eliminating swelling of the skin.

One of these drugs is Nise ointment, the instructions for use contain detailed information about the rules of use.

What does Nise ointment help with?

The drug Nise for external use has a general anti-inflammatory effect on the lesion and is used to eliminate symptoms of pain.

Most often prescribed for the following situations:

arthritis;
gout;
psoriatic arthritis;
osteochondrosis;
osteoarthritis;
radiculitis;
inflammatory formations on ligaments and tendons;
joint damage;
damage to soft tissues with the presence of inflammation;
unpleasant symptoms in the postoperative period;

Can be used for pain in the muscles after prolonged physical activity.

Composition and release form

The medicinal substance Nise for external use does not contain hormones and is used for complex therapy for the treatment of large numbers of diseases.

The drug Nise for external use is available in the form of a gel. white with a specific smell.

Compound medicinal substance:

nimesulide;
propylene glycol;
macrogol;
isopranol;
butylated hydroxyanisole;
dihydrogen phosphate;
menthol;
purified water.

Available in a plastic tube of 20, 50 mg, which is located in a cardboard package.

Operating principle

The drug Nise belongs to a new generation of substances for eliminating pain symptoms. When the substance is used, the active component nimesulide penetrates into the damaged area and reduces the development of the inflammatory process.

The drug quickly eliminates pain and reduces swelling of the tissue. Menthol soothes the epidermis and prevents the formation of allergic reactions. When used, additional components of the gel have an antiseptic effect. The use of Nise allows you to narrow blood vessels and eliminate unpleasant symptoms.

Good to know! During the inflammatory process, a decrease in the level of blood circulation is very often observed; the medicinal substance normalizes blood circulation, blocks further development diseases.

Instructions for use of the drug

Clean the surface of the epidermis with warm water and dry with a towel;
Apply a small amount of product to the skin, spread in a thin layer;
the medicine remains on the skin until completely absorbed;
It is recommended to apply the product 3 times a day;
at complex types diseases, the dosage can be increased by the attending physician;
The duration of treatment is no more than 10 days.

The helium structure of the substance allows the product to be evenly distributed and not clog the pores of the epidermis.

Stories from our readers!
"I cured my bad back on my own. It’s been 2 months since I forgot about the pain in my back. Oh, how I used to suffer, my back and knees hurt, lately I couldn’t really walk normally... How many times did I go to clinics, but they only prescribed expensive pills and ointments, which were of no use at all.

And now it’s been 7 weeks, and my back joints don’t bother me at all, every other day I go to the dacha to work, and it’s a 3 km walk from the bus, so I can walk easily! All thanks to this article. A must read for anyone with back pain!"

Contraindications for use

individual sensitivity to the components of the drug;
pregnancy and breastfeeding;
the presence of open wounds on the epidermis;
age up to 7 years;
liver and kidney disease;
dermatosis;
infectious rashes on the epidermis.

Let's celebrate! For elderly people, it is necessary to use the drug with caution to prevent complications of the disease.

Side effects and overdose

During Nise applications The following side symptoms may occur:

allergy;
dizziness;
swelling of the skin;
increased sweating;
nausea.

At correct use Cases of drug overdose are quite rare. However, when Nise is prescribed independently, symptoms may appear following symptoms overdose: nausea, swelling of the skin, general weakness, dizziness, rash on the epidermis in the form of blisters.

If such symptoms occur, you must stop using the product and contact a medical facility.

Pain and crunching in the back over time can lead to dire consequences- local or complete restriction of movements, up to disability.

People, taught by bitter experience, use natural remedy which orthopedists recommend...

Cost of Nise ointment

The drug in the form of a gel for external use has an average cost of 80 rubles for 20 mg, 170 rubles for a 50 mg tube.

Drug interactions

Prohibited use medicinal product Nise with the substances digoxin, phenytoin, diuretics, methotrexate. Not used in conjunction with diabetic medications.

Analogues and their cost

If there is a need to use drugs with a similar effect, you can purchase the following types:

Nimesulide - a drug in gel form has the same properties as Nise. The average cost is 130 rubles.
Nimulide - the active component of the drug nimesulide, is an analogue of the drug Nise, and is widely used to eliminate inflammation and pain symptoms. Price 120 rubles.
Naisulide is the cheapest analogue of Naise and has the property of relieving inflammation and swelling of the skin. Price 60 rubles.
Nimik - the drug has the property of deep penetration and elimination of unpleasant symptoms. Average price 150 rubles.

Note! Before using any similar drug, you should consult a doctor. Each analogue may contain additional components that can cause unexpected side symptoms.

User reviews

After undergoing surgery in the knee joint, pain appeared that was chaotic in nature. I use Nise for external use 2 times a day during periods of exacerbation of pain. Eliminates quickly discomfort and reduces swelling of the skin.

Elena, 37 years old

I'm working out active look sports and very often suffer from sprains muscle tissue. Nise comes to the rescue. After several applications, the unpleasant symptoms disappear.

Arthur, 26 years old

I used the product to eliminate lower back pain, after the second day of use the skin appeared red and itchy. Now I use medications to eliminate allergic reactions.

Margarita, 52 years old

The medicinal substance Nise has strong effect against various types of inflammatory processes in soft tissues and joints. It has a pronounced property of eliminating pain symptoms.

*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)

Registration number:

P N012824/02

Trade name: Nise ®

International nonproprietary name:

nimesulide

Chemical name: N-(4-nitro-2-phenoxyphenyl) methanesulfonanilide

Dosage form:

gel for external use

Compound:

1 g of gel contains:

active substance: nimesulide 10 mg;

excipients: N-methyl-2-pyrrolidone 250 mg, propylene glycol 100 mg, macrogol 315.5 mg, isopropanol 100 mg, purified water 200 mg, carbomer-940 20 mg, butylated hydroxyanisole 0.2 mg, thiomersal 0.1 mg, potassium dihydrogen phosphate 0 .2 mg, flavor (Narcissus-938) 4 mg.

Description: transparent gel light yellow or yellow, free from foreign particles.

Pharmacotherapeutic group:

non-steroidal anti-inflammatory drug (NSAID)

ATX Code: M01AX17

Pharmacological action

Nise ® gel is a new generation non-steroidal anti-inflammatory drug (NSAID) from the sulfonamide class. It has a local analgesic and anti-inflammatory effect.

Nimesulide - selective competitive reversible inhibitor cyclooxygenase type II (endoperoxide-prostaglandin-H 2 synthetase). Reduces the concentration of short-lived prostaglandin H2, a substrate for kinin-stimulated synthesis of prostaglandin E2, at the site of inflammation and in the ascending pathways of pain impulses in spinal cord. A decrease in the concentration of prostaglandin E 2 (a mediator of inflammation and pain) reduces the activation of EP type prostanoid receptors, which is manifested by analgesic and anti-inflammatory effects.

When applied topically, it causes a weakening or disappearance of pain at the site of application of the gel, including pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints. Helps increase range of motion.

Pharmacokinetics

When applying the gel, the concentration of the active substance in the systemic circulation is extremely low. The maximum concentration after a single application is observed at the end of the first day; its value is more than 300 times lower than that for oral dosage forms of nimesulide. No traces of the main metabolite of nimesulide, 4-hydroxynimesulide, are found in the blood.

Indications

Local symptomatic treatment of inflammatory and degenerative diseases musculoskeletal system(articular syndrome during exacerbation of gout, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteochondrosis with radicular syndrome, radiculitis, inflammatory lesion ligaments, tendons, bursitis, sciatica, lumbago).

Muscle pain of rheumatic and non-rheumatic origin.

Post-traumatic inflammation of soft tissues and the musculoskeletal system (damage and rupture of ligaments, bruises).

Contraindications

Hypersensitivity to nimesulide and the components of the drug; erosive and ulcerative lesions gastro- intestinal tract in the acute stage, bleeding from the gastrointestinal tract, dermatosis, damage to the epidermis and infection skin in the field of application; severe renal (creatinine clearance less than 30 ml/min.) or liver failure, a history of bronchospasm associated with the use of acetyl salicylic acid or other NSAIDs, pregnancy and lactation, childhood up to 7 years.

With caution

Liver failure; renal failure; severe heart failure; arterial hypertension; diabetes mellitus 2 types; elderly and children's age.

Directions for use and doses

Externally. Before applying the gel, wash and dry the skin surface. Apply a uniform thin layer of gel approximately 3 cm long to the area of maximum pain, without rubbing, 3-4 times a day.

The amount of gel and the frequency of its use (no more than 4 times a day) may vary depending on the size of the treated area and the patient’s response.

Do not use the gel for more than 10 days without consulting a doctor.

Side effect

Local reactions: itching, urticaria, peeling, transient change in skin color (not requiring discontinuation of the drug).

If any adverse reactions occur, you should stop using the drug and consult your doctor.

When applying the gel to large areas of the skin or with prolonged use, the development of systemic adverse reactions is possible: heartburn, nausea, vomiting, diarrhea, gastralgia, ulceration of the gastrointestinal mucosa, increased activity of “liver” transaminases; headache, dizziness; fluid retention, hematuria; allergic reactions (anaphylactic shock, skin rash); thrombocytopenia, leukopenia, anemia, agranulocytosis, prolongation of bleeding time.

Overdose

Cases of drug overdose have not been described. However, when large amounts of gel (exceeding 50 g) are applied to large areas of skin, the development of an overdose cannot be ruled out. There is no specific antidote. You need to see a doctor.

Interaction with other drugs

Pharmacokinetic interactions with drugs that compete for binding to plasma proteins cannot be ruled out.

Caution should be exercised when using Nise ® simultaneously with digoxin, phenytoin, lithium preparations, diuretics, cyclosporine, methotrexate, other NSAIDs, antihypertensive and antidiabetic agents.

Before using the gel, you should consult your doctor if you are using these products or are under medical supervision.

Special instructions

It is recommended to apply the drug only to intact areas of the skin, avoiding contact with open wounds. Avoid getting the gel into the eyes and other mucous membranes. Do not use the gel under airtight dressings. After applying the gel, wash your hands with soap. Close the tube tightly after using the gel.

Thomas release

Gel for external use 1%. 20 g or 50 g in a laminated aluminum tube equipped with a membrane to control the first opening. The tube is packed in a cardboard box with instructions for use.

Best before date

Do not use the drug after the expiration date indicated on the package.

Storage conditions

List B.

In a dry place, protected from light, at a temperature not exceeding 25 ° C. Do not freeze.

Keep out of the reach of children!

Conditions for dispensing from pharmacies

Over the counter.

Manufacturer

Dr. Reddy's Laboratories Ltd.

Hyderabad, Andhra Pradesh, India.

Address of production place

Dr. Reddy's Laboratories Ltd.

Plot No. 41, Nasigere Village, Kasaba Hobli, KIADB, Malur-563130, Karnataka, India.

Consumer complaints should be sent to:

Representative office of Dr. Reddy and Laboratories Ltd.:

115035, Moscow, Ovchinnikovskaya embankment, 20, building 1

The drug "Nise" - gel for local application. What kind of medicine is it, what are its indications, side effects, pharmacological action and other information you will find in the materials of this article.

Appearance of the medication

The drug "Nise" is a purely transparent 1% gel with a light yellow tint. This product has a uniform consistency, without foreign particles. The medication is available in aluminum tubes of 20 and 50 g, packed in cardboard boxes with detailed instructions.

Composition of the product

The medicine "Nise" is a gel containing active ingredients such as nimesulide, methyl salicylate, menthol and capsaicin. In addition, the presented drug includes auxiliary components:

diethylene glycol ethyl ether;
diethyl phthalate;
polyoxyl 40 hydrogenated;
propylene glycol;
castor oil;
disodium edetate;
sodium benzoate;
purified water;
carbomer-980;
trometamol;
butylated hydroxytoluene;
propylene glycol.

Pharmacological action

“Nise” is a gel, which is a non-steroidal anti-inflammatory drug for external use only. It has an analgesic effect, relieves swelling and inhibits platelet activation. When used, this medication first causes a weakening and then a complete disappearance of pain at the site of application of the drug, including pain in the joints and muscles (during movement and at rest). Among other things, Nise gel significantly reduces morning swelling and stiffness of the body, and also helps to increase the range of painless movements.

Action of active substances

As mentioned above, the drug "Nise" includes the following active substances, such as nimesulide, methyl salicylate, menthol and capsaicin. What role do they play in the presented medicine? You will get the answer to this question below.

Nimesulide is a selective cyclooxygenase-2 inhibitor. It exhibits anti-inflammatory and analgesic effects.
Methyl salicylate is a derivative of salicylic acid. It has a distracting and local irritating effect.
Menthol promotes an analgesic effect, which is accompanied by a feeling of slight chill.
Capsaicin has locally irritating properties, causes tissue hyperemia and increased blood flow at the site of application, and also promotes the removal of biological endogenous substances.

Pharmacokinetics

This form of the drug is characterized by fairly high safety of use (side effects from the gel are practically not detected). When used externally, Nise is gradually absorbed from the skin into the muscles and a balance between them is quickly achieved.

Indications for use of the drug

Gel for external use “Nise” (the description of the drug was presented above) is recommended for use for the following deviations:

psoriatic arthritis;
rheumatoid arthritis;
osteochondrosis with radicular syndrome;
ankylosing spondylitis;
articular syndrome due to gout and rheumatism;
lumbago;
post-traumatic inflammation of the musculoskeletal system, soft tissues (various ruptures and damage to ligaments, as well as bruises);
radiculitis;
osteoarthritis;
sciatica;
inflammation of tendons and ligaments, bursitis;
myalgia of non-rheumatic and rheumatic origin.

Contraindications to the use of the drug

Like any medicine intended for external use, Nise gel also has contraindications for use. These include the following:

hypersensitivity to the constituent substances of the drug;
severe impairment of kidney and liver function;
peptic ulcer of the duodenum and stomach (especially in the acute stage);
infectious diseases skin and dermatitis;
pregnancy period;
lactation period.

Special instructions for the use of the drug

Nise gel should be used externally only. It should be used with extreme caution in sick elderly people, as well as those who have significant impairments in kidney and liver function, and patients with congestive heart failure. It is advisable to apply this drug only to intact areas of the skin, while avoiding contact with the eyes, mucous membranes, open wounds and ulcers. Do not use the gel under tight or airtight bandages. Before and after using the drug, it is recommended to wash your hands well with soap. At the end of treatment, the tube with the gel should be tightly closed.

How to use the product

Before direct use gel, the surface of the skin must be washed and dried thoroughly. After this, a strip of the product about 3 centimeters long should be applied in a thin and even layer to the area of maximum pain. In this case, rubbing the gel intensively is not recommended.

Dosage of the drug

The amount of Nise and the frequency of its use should vary depending on the size painful area skin, as well as the patient's reaction. However, it is not advisable to use this medication more than 4 times a day. Maximum dose gel should be about 30 g per day. The duration of treatment (pain relief) with the presented remedy is 10 days. If you need to use the drug for a longer period of time, you should definitely consult a doctor.

Overdose

Currently, cases of overdose with this drug have not been observed. But if you use the gel in an amount of more than 50 g on large areas of the skin, the patient may experience adverse reactions. In this case, you should immediately consult a doctor.

Side effects

When applying the drug "Nise" to large areas, the following side effects may develop:

From the gastrointestinal tract: vomiting, heartburn, nausea, stomach pain, diarrhea, increased activity of liver enzymes and erosive and ulcerative lesions of the gastrointestinal tract.
From the side of the central nervous system: dizziness and severe headaches.
From the side of hematopoiesis: agranulocytosis, anemia, thrombocytopenia, prolongation of bleeding time and leukopenia.
From the urinary system: hematuria and fluid retention.
Allergic reactions: anaphylactic shock and skin rash.
Local reactions: peeling, itching, change in skin color and urticaria.

Terms and conditions of storage

The shelf life of this drug is 24 months from the date of manufacture. It is recommended to store Nise gel out of the reach of children and in a cool place at a temperature not exceeding 23°C. Freeze this remedy is strictly prohibited. It should also be noted that pharmacy chains sell it without a doctor’s prescription.

Other forms of release

This drug is available not only in the form of a gel, but also in the form of a suspension for oral administration (for children younger age). The remedy “Nise” for toothache should be used in tablet form in the amount of 1 or 2 pieces (depending on the intensity).

Cost of the drug

Depending on the form of release of the drug presented, its price can vary significantly. Thus, Nise tablets in the amount of 20 pieces (pack) in different pharmacy chains cost about 140-150 Russian rubles. As for the anesthetic gel, for a 20-gram tube you will have to pay about the same amount, but for a suspension (60 ml) pharmacists ask about 230 rubles.

Nonsteroidal anti-inflammatory drugs are used in most areas of modern medical practice, but most often they are prescribed to patients suffering from rheumatological diseases and nonspecific inflammatory processes musculoskeletal system. A prominent representative of NSAIDs is the drug Nise, created on the basis of nimesulide, which is highly effective and provides a rapid onset of analgesic effect.

This medicine is reliable way solutions to many problems with joints, interarticular cartilage tissues, tendons. It is often recommended for patients with sprains of muscle tissue, inflammation of bone joints, diseases of the spine of a degenerative-destructive nature, and the like. Nise can be used as pain relief after surgical interventions or dental treatment. This medicine has proven itself excellently as faithful assistant in the fight against inflammation of non-infectious origin. A huge advantage of the drug is the possibility of its use in childhood.

Instructions for using the medicine

This representative of the NSAID group has several types of action, including analgesia, anti-inflammatory and decongestant. In addition, the drug has a pronounced antipyretic effect, which allows it to be used to relieve fever of various origins.

What does Nise help with? The drug is used for symptomatic treatment huge amount pathological conditions, in particular, it is prescribed for diseases of the spine, pain syndrome associated with injuries, menstrual pain, headaches and toothaches. The medicine helps to quickly reduce elevated temperature, accompanying viral and bacterial infections, it reduces the ability of platelets to aggregate and prevents the formation of blood clots.

Nise is one of the medicines, the use of which is the reason for the development of numerous side effects. Long-term and regular use of the medicine can cause various allergic reactions of local and general, violations from the central nervous system and functioning disorders digestive tract in the form of gastritis, diarrhea, flatulence and the like. Often the urinary organs react to taking the medication, which is manifested by the occurrence of local swelling, hematuria, painful urination and renal failure. Often, after using the medicine, patients complain of shortness of breath, disorders heart rate, hemorrhages throughout the body, exacerbation of symptoms bronchial asthma. Rarely, after using the drug, people experience worsening vision, a decrease in temperature, and general weakness.

The drug has huge amount Contraindications that should be taken into account before starting to take it:

individual intolerance to the components of the product;
previous allergic reactions to structural analogues of the drug;
period of pregnancy and breastfeeding;
diseases of the stomach and intestinal tract in the acute phase;
the presence of bronchial asthma in a person and frequent attacks of bronchospasm of various etiologies;
hemophilia and bleeding disorders;
failure internal organs at the stage of decompensation;
alcohol dependence and drug addiction;
rehabilitation period after coronary artery bypass surgery;
gastrointestinal bleeding.

A drug overdose occurs as a result of non-compliance with the recommended doses of the drug. Its symptoms are manifested by the development of dyspepsia, nausea and vomiting, increased blood pressure, sometimes severe impairment of kidney function and convulsive syndrome. Treatment of overdose comes down to washing the patient’s stomach and taking sorbents, as well as prescribing laxatives and symptomatic therapy.

Nise: tablets for internal use

Tablets are the main form of the drug for internal reception. They are taken orally during or after main meals. This helps prevent irritation of the mucous membranes of the stomach. Regular tablets are prescribed to children over 12 years of age and adults. Taking medication in preschool and younger children school age prohibited.

There are also dispersed tablets. This form of release of the drug is intended for patients over 3 years of age. Before use, pills must be dissolved in clean water and then drink without drinking a large number liquids. Like regular tablets, the dispersed version of the medication should only be taken on a full stomach. Water for dissolution is taken in the ratio of 1 tablet per 5 ml of liquid.

The recommended dose of the drug for adults and older children, as well as people over 65 years of age, is 100 mg (2 tablets) twice a day. If necessary, it can be increased to 4000 mg per day, but this is the maximum daily dosage means. If the specified amounts are not observed, the patient may experience poisoning.

Small children take the drug in quantities calculated according to the following scheme: 3-5 mg active substance for every kilogram of the child’s body weight. The duration of taking the drug is determined by the attending physician.

Nise gel

Dosage form used for local use as a means to relieve local pain. Before applying the medication, the skin at the site of exposure should be treated soap solution and wipe with a towel. If a wound appears on the skin in the area where pain is projected and symptoms of inflammation appear or there are signs of irritation (dermatitis), then applying the gel is prohibited.

The gel is applied to the skin 3-4 times a day. To do this, you need to squeeze out about 3 cm of the product from the tube and rub it into the skin with soft massage movements. After the procedure, the treatment site can be covered with gauze or left open. Anesthetic medicine should not be covered on top with materials that do not allow air to pass through.

The use of the gel must be strictly according to the instructions. Before use, it is better to visit a doctor and decide on individual doses, duration of treatment, etc. It is not recommended to apply the product for more than four days, as after of this period the risk of side effects increases sharply. IN in some cases The gel is prescribed in courses lasting 10 days.

After applying the product to the skin, a superficial burn may occur locally, the manifestations of which go away on their own after a few days. In addition, the components of the gel can provoke itching and burning of the skin, which indicates that the patient has an individual intolerance to some components of the drug. After using the product, a person should wash their hands well to prevent the gel from getting into the eyes or mucous membranes. Maximum daily dose the product should not exceed 30 g, that is, 1.5 tubes.

Ointment Nise

The non-steroidal anti-inflammatory drug is available in tubes for topical use. This is a so-called gel that should be applied to the skin in areas of pain. Many people who do not know the subtleties of distributing medications into forms mistakenly confuse it with an ointment. It is important to understand that Nise is produced exclusively in the form of a gel and has no analogues identical in name among liniments.

Nise - composition of the medicine

The composition of the drug depends on the form of its release. Regular tablets contain:

nimesulide as the main active ingredient in the amount of 100 mg per tablet;
excipients, including talc, starch, cellulose, calcium hydrogen phosphate and others.

The tablets are white flat cylinders with a smooth surface.

The drug in the form of dispersible tablets contains:

nimesulide – 0.050 g per tablet;
talc, starch, cellulose, pineapple flavor, aspartame, silicon dioxide.

Gel for topical use contains nimesulide 1% (10 ml of gel - 1 g of nimesulide). The medicine is packaged in 20 ml tubes. This is a white gel without visible inclusions or strong odors.

Indications for use of the drug

Among the main indications for the use of the drug are:

rheumatoid arthritis of large joints and polyarthritis;
exacerbation of gouty arthritis;
arthritis of psoriatic origin with severe pain;
ankylosing spondylitis;
radicular syndrome with radiculitis, neuralgia, radiculopathy;
osteochondrosis of the spinal column;
myalgia of various origins;
inflammatory processes of the constituent parts of the joints, including aseptic inflammation during sprains, damage to the capsule and muscle structures;
pain syndrome, regardless of origin;
hyperthermia.

The drug can be used internally, as well as locally by applying to the skin. The medicine is indicated for adults and children over 12 years of age. Soluble tablets can be used in young patients who have reached the age of three.

Nise: price of the drug

Patients often ask how much it costs this drug, because it is one of the foreign medicines? Indeed, the product costs a little more domestic analogues, but still its price remains acceptable for the majority of our fellow citizens.

Today you can purchase the drug at any pharmacy. The dosage form is available without a prescription, but before use it is recommended to mandatory consult with specialists regarding dosages, frequency of administration and duration of the therapeutic course.

Analogues that can replace the drug

Mostly, patients are interested in analogues of the drug when they are looking for a cheaper replacement. In the case of Nise substitutes, the pharmaceutical market is simply replete with an abundance of drugs from the NSAID group, among which a person can purchase:

generics of the drug or its structural analogues (drugs identical in composition and main active ingredient);
analogues according to the principle of action (medicines where the main active ingredient is not nimesulide, but another NSAID).

Among the most popular drugs containing nimesulide are the drug Nimesulide itself, Aulin Ameolin, Nimesil Nimulide and others. If a person is intolerant to nimesulide, he may be offered an NSAID based on another active component in particular, Artron, Mesulide, paracetamol preparations, Diclofenac, Dikloberl, Structum and the like.

Nise gel contains nimesulide, a selective COX-2 inhibitor. It has an analgesic and anti-inflammatory effect due to the inhibition of COX-2, which leads to inhibition of the synthesis of prostaglandins, which are involved in the formation of edema and pain during inflammation. Nimesulide inhibits platelet activating factor, tumor necrosis factor alpha, the release of proteinases and histamine.
Methyl salicylate, a derivative of salicylic acid, has a local irritating and distracting effect.
Menthol has an analgesic effect, accompanied by a feeling of cold. The analgesic effect of menthol is associated with stimulation of cold receptors, stabilization of calcium ion flows through the channels of neuronal membranes.
Capsaicin has a local irritant effect, causes a local increase in blood flow and tissue hyperemia at the site of application, and promotes the release of endogenous biologically active substances.
Nise gel is characterized by high safety of use (virtually no side effects are noted). When applied externally, the gel is gradually absorbed through the skin into the underlying muscle or synovial fluid. Equilibrium concentrations between skin and muscle or synovial fluid are achieved quickly.
With local application of Nise gel, systemic absorption is insignificant, since the levels of nimesulide in the blood plasma remained below the detection limit of high-performance liquid chromatography and only after 5 hours very low concentrations (100 μg/l) of hydroxynimesulide in the blood plasma were detected.

Indications for use of the drug Nise gel

Osteoarthritis (including rheumatoid arthritis), osteoarthritis, tenosynovitis, bursitis, synovitis, lumbodynia; post-traumatic inflammation of tendons, ligaments, muscles, joints.

Use of the drug Nise gel

Apply a 3 cm long column of gel to the affected area of skin in a thin layer 2-3 times a day and rub in lightly. Before applying the gel, thoroughly wash and dry the skin surface. Do not use the gel for more than 10 days.

Contraindications to the use of the drug Nise gel

Hypersensitivity to the components of the drug; severe dysfunction of the liver and kidneys; stomach ulcer and duodenum in the acute stage, dermatitis and infectious skin diseases; period of pregnancy and lactation; patients who have acetylsalicylic acid and other NSAIDs have caused symptoms of asthma, rhinitis, angioedema or allergic rashes on the skin.

Side effects of the drug Nise gel

At the site of application of the drug, itching, erythema, rash, redness, peeling, and skin burns may be noted.

Special instructions for the use of Nise gel

The drug is intended for external use. Elderly patients with significant impairment of liver and kidney function, patients with congestive heart failure should use the drug with caution. It is recommended to apply the gel only to intact areas of the skin, avoid contact with open wounds. Do not use the gel under airtight or tight bandages. Avoid getting the gel into the eyes and mucous membranes. Wash your hands thoroughly before and after using the gel.
Indications for use of the gel in children and dosage have not been established.