What is Nise Gel ointment for? Nise gel - official* instructions for use
Nise gel is one of the options for non-steroidal anti-inflammatory drugs for topical use. The composition of this gel includes 10 mg of active substance (nimesulide) per 1 gram of gel. The product itself is light yellow in color. Available in tubes of 20 and 50 grams.
Pharmacologically, nimesulide is one of last generations anti-inflammatory drugs and is a relatively selective reversible inhibitor cyclooxygenase-2. In its action, it reduces the concentration of inflammatory cytokines, reduces the amount of synthesized pain mediators, which, in turn, leads to good analgesic and anti-inflammatory effects.
Local use Nise gel leads to a decrease pain syndrome(sometimes up to the relief of moderate pain), reduces swelling of inflamed joints, helps to increase the range of active movements by reducing pain.
Pharmacokinetically, it is practically not absorbed into the blood when applied topically. The maximum concentration is detected at the end of the first day. The concentration of nimesulide in the blood is several hundred times lower than when using tablets and powders. Metabolites are not detected in the blood at all.
Indications for use
Nise gel in neurological practice indicated primarily for vertebrogenic pain syndromes. Can also be used in rheumatological practice, in the treatment next pathology:
- Exacerbation of gout with articular syndrome.
- Arthritis of various etiologies.
- Muscle pain of various origins.
- Post-traumatic inflammation of soft tissues.
- Sprain.
- Inflammatory diseases of the ligamentous apparatus.
Contraindications
Despite the fairly high safety of using Nise gel, there are a number of contraindications for the use of the drug:
- Allergic reactions.
- Erosion and ulcer in the gastrointestinal tract in the acute phase.
- Bleeding from the gastrointestinal tract, incl. according to anamnesis.
- Skin damage in the area of intended use.
- Heavy renal failure With low level creatinine clearance (below 30 ml per minute).
- Terminal liver failure.
- Pregnancy and lactation.
- Aspirin dependent bronchial asthma, including attacks on taking NSAIDs according to anamnesis.
- Children under 7 years of age (under 18 years of age, use with caution).
It should also be used with caution in people with diabetes, with uncontrolled blood pressure, with end-stage heart failure, with unstable angina.
Dosage
For external use only. It is advisable to clean and dry the skin before use. Apply a thin layer to the area of pain, the length of the gel column is 3-4 cm. Do not rub in, use up to 4 times a day.
You should not use Nise gel for more than 10 days without consulting a healthcare professional.
Overdose
Cases of overdose have not been described in the literature. Overdose phenomena are possible when using the gel in doses over 50 grams. There is no antidote; use symptomatic treatment.
Side effects
The following side effects are possible when using the gel:
- The most common local reactions are itching, peeling, urticaria, and changes in skin color (temporarily). Most often, treatment discontinuation is not required.
- Theoretically, systemic adverse reactions when used for a long time or high doses: vomiting, stool disturbance, heartburn, ulcerative lesions of the mucous membranes, increased transaminase activity, dizziness, anaphylactic shock, prolongation of bleeding time, change in blood picture.
Special instructions
- It is not advisable to apply to damaged skin or mucous membranes. Do not use in compresses or tight bandages. Wash your hands after application. Close the lid after use.
- Use carefully in combination with digoxin, lithium preparations (psychiatric practice), cytostatics, and other non-steroidal drugs, diuretics, antihypertensive and hypoglycemic drugs for the uncontrolled course of these diseases. When a patient uses these groups of medications, it is necessary to consult a doctor.
- Store at room temperature, do not freeze. Shelf life up to two years.
Gel price
Available in pharmacies without a prescription. Prices for the drug (relevance as of December 21, 2014) vary from pharmacies’ markups and are approximately from 140 to 220 rubles per 20 gram package and from 250 to 335 rubles per 50 gram package.
The drug Nise gel is a proven remedy for eliminating inflammation, pain and swelling in many pathologies of the musculoskeletal system. After application, the composition actively acts on the affected area, but practically does not penetrate into the bloodstream, which reduces the risk adverse reactions.
In the instructions for Nise gel, the manufacturer indicates important points on the use and effect of NSAIDs. If the recommendations are followed, side effects occur infrequently, the drug actively eliminates negative symptoms.
Composition and action
Nise ointment (gel) - important element treatment of pathologies of the spine and back. The composition with nimesulide is a new generation drug for eliminating pain and inflammation in cases of damage to bone and cartilage structures, muscles and joints.
The active ingredient in Nise gel is nimesulide. 1 g of composition contains 10 mg active component. In pharmacies you can buy a tube with 50 g of the drug. The main advantage of new types of NSAIDs is their selective action, selective blocking of mediators of pain and inflammation without negative influence for the useful enzyme cyclooxygenase - 1.
After application, nimesulide gradually penetrates into the affected tissues, synovial fluid and joints, blocks the production of cyclooxygenase-2, prevents the synthesis of leukotrienes and prostaglandins, causing negative reactions. The result of therapy is a reduction in pain, swelling, and suppression of inflammation. After the disappearance of negative symptoms, the mobility of problem joints improves and the stiffness of the affected area decreases. The components of the drug based on nimesulide are completely eliminated from the body and do not affect the composition of blood plasma and the functioning of the central nervous system.
The manufacturer offers not only Nise gel, but also others dosage forms: suspension, tablets for oral administration and dispersible variety (effervescent tablets).
Indications for use
What does Nise gel help with? A local nimesulide-based remedy is effective for the following diseases:
- rheumatism;
- bursitis;
- inflammation of cartilage, joints, bone tissue after injuries and injuries;
- gout;
- osteoarthritis;
- ankylosing;
- arthralgia;
- synovitis;
- pain in the spine;
- Tenosynovitis.
What to do if from the back? Read about the symptoms and treatments for possible illnesses.
About the types of pathology, characteristic symptoms And effective methods myalgia treatment written on the page.
Contraindications
Despite the “milder” effect on the body, the drug based on nimesulide has limitations. It is important to find out the presence of contraindications before starting therapy in order to prevent side effects.
Nise gel is not prescribed if available following states and pathologies:
- erosions and ulcers of the gastrointestinal tract (with exacerbation of the process);
- excessive sensitivity to the active substance - nimesulide or other components of NSAIDs;
- bleeding in the body of any etiology and intensity;
- age up to 8 years;
- hepatitis, liver cirrhosis, high level liver enzymes;
- on the affected area there are wounds, scratches, purulent nodules, and dermatosis develops;
- pregnancy;
- severe kidney damage;
- lactation period;
- The patient had previously reported bronchospasm after using non-steroidal anti-inflammatory compounds.
Note! At high rates Blood pressure, in old age, with serious illnesses hearts, diabetes mellitus(type II) caution must be exercised when prescribing a drug based on nimesulide. The development of undesirable reactions is a reason to discontinue the drug and re-consult with the attending physician.
Instructions for use
Apply the drug Nise in gel form only externally, to painful area. The product is not suitable for treating large areas.
- Before applying the composition, wash and wipe the problem area dry;
- small amount of Nise gel ( best option- no more than 3 cm) squeeze onto the painful area, rub, but without strong pressure;
- after treatment there should be a thin layer on the surface of the epidermis local remedy;
- some patients feel a slight burning sensation, but after 5-6 minutes discomfort disappear;
- During processing, care must be taken to ensure that the drug does not get into the eyes, mouth, or mucous membranes. After the procedure, be sure to thoroughly remove any remaining gel from your hands, wash and wipe dry. skin so that no particles of the drug remain on the fingers and palms;
- the frequency of application of the anti-inflammatory composition is 3 or 4 times a day. To achieve a lasting effect, you need to apply the gel to the affected area daily;
- The maximum duration of therapy is 10 days. Important to know: if after 2 weeks there is no noticeable improvement, then you should definitely visit a vertebrologist or neurologist, choose a substitute or NSAID based on another active ingredient.
Side effects
In the background individual characteristics undesirable manifestations are possible. In most cases, negative symptoms occur when instructions are violated or when nimesulide enters the body in excess during long period. Characteristic reactions appear locally: swelling, redness, spreading of the rash in the treated area.
In case of overdose, the risk of negative symptoms is increased:
- dizziness;
- diarrhea, nausea, vomiting;
- pronounced swelling, fluid retention;
- dizziness;
- development of liver failure.
Nimesulide is poorly absorbed into deep tissues, there is practically no systemic effect: after a day the concentration active substance in the bloodstream is 300 times lower than with orally medicine. Application of Nise gel according to the instructions allows you to avoid side effects. Majority negative reactions occurs with prolonged use of the composition, processing large areas.
Drug interactions
Some groups of drugs need to be prescribed with caution during treatment with a new generation of NSAIDs. For this reason, it is prohibited to purchase medicine for external application on problem areas, if certain compositions of other categories were previously assigned.
It is not advisable to combine Nise gel with:
- diuretics;
- cyclosporines;
- drugs Phenytoin, Digoxin;
- hypoglycemic agents for oral administration;
- lithium preparations;
- compositions for lowering blood pressure;
- other types of non-steroidal compounds to eliminate inflammation, swelling and pain in cartilage, bone and muscle tissue.
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Rules of application vitamin complex Neurobex Neo included complex therapy diseases of the spine are described on the page.
Go to the address and read about the symptoms of a pinched nerve in the spine in thoracic region and about methods of treating pathology.
Price
An effective drug, Nise gel, has a selective action (new generation), but unlike many drugs in this category, the cost of the local product is suitable for most patients. The price of Nise gel ranges from 170 to 220 rubles (50 g). You do not need a prescription to purchase the anti-inflammatory composition. A room with a temperature of up to +25 C, without excessive dampness, is suitable for storage.
Gel Nise: analogues
If prescribed by a doctor, the patient can purchase another product based on Nimesulide. New generation non-steroidal anti-inflammatory drugs are safer for the body, systemic reactions occur less frequently.
Nise gel - modern drug, after the use of which patients feel relief from osteochondrosis, radiculitis, lumbago, arthralgia, myositis, after injuries and severe bruises/sprains. Nimesulide does not have any effect systemic action, negative symptoms during therapy appear in a small number of cases. The composition for external use reduces negative symptoms without negative influence on the central nervous system and circulatory system.
In this article you can find instructions for use medicinal product Nise. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Nise in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Nise in the presence of existing structural analogues. Use for the treatment of pain and inflammation in joints and muscles in adults, children, as well as during pregnancy and breastfeeding.
Nise- non-steroidal anti-inflammatory drug. Selective inhibitor of COX-2 - an enzyme involved in the synthesis of prostaglandins - mediators of edema, inflammation and pain. The drug has anti-inflammatory, analgesic and antipyretic effects.
Reversibly inhibits the formation of prostaglandin E2, both at the site of inflammation and in the ascending pathways of the nociceptive system, including the pathways of pain impulses in the spinal cord.
Reduces the concentration of short-lived prostaglandin H2, from which prostaglandin E2 is formed under the action of prostaglandin isomerase. A decrease in the concentration of prostaglandin E2 leads to a decrease in the degree of activation of EP-type prostanoid receptors, which is expressed in analgesic and anti-inflammatory effects.
It has a slight effect on COX-1 and practically does not interfere with the formation of prostaglandin E2 from arachidonic acid in physiological conditions, due to which the amount of side effects drug.
Nise suppresses platelet aggregation by inhibiting the synthesis of endoperoxides and thromboxane A2, and inhibits the synthesis of platelet aggregation factor. Suppresses the release of histamine and also reduces the degree of bronchospasm caused by exposure to histamine and acetaldehyde.
It has been shown that nimesulide ( active substance drug Nise) is able to suppress the synthesis of interleukin-6 and urokinase, thereby preventing the destruction cartilage tissue. Inhibits the synthesis of metalloproteases (elastase, collagenase), preventing the destruction of proteoglycans and collagen of cartilage tissue.
It has antioxidant properties and inhibits the formation of toxic oxygen breakdown products by reducing the activity of myeloperoxidase. Interacts with glucocorticoid receptors, activating them through phosphorylation, which also enhances the anti-inflammatory effect of the drug.
At local application causes a weakening or disappearance of pain at the site of application of the gel, incl. pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints. Helps increase range of motion.
Pharmacokinetics
After oral administration, Nise is well absorbed from the gastrointestinal tract. Eating reduces the rate of absorption without affecting its extent. Penetrates into the tissues of the female genital organs, where after a single dose the concentration of nimesulide is about 40% of the concentration in plasma. Penetrates well into the acidic environment of the inflammation site (40%) and synovial fluid (43%). Easily penetrates histo-hematological barriers. The metabolite is excreted by the kidneys (65%) and bile (35%).
Indications
- rheumatoid arthritis;
- articular syndrome with rheumatism and exacerbation of gout;
- psoriatic arthritis;
- ankylosing spondylitis;
- osteochondrosis with radicular syndrome;
- radiculitis;
- sciatica;
- lumbago;
- osteoarthritis;
- arthritis of various etiologies;
- arthralgia;
- myalgia of rheumatic and non-rheumatic origin;
- inflammation of ligaments, tendons, bursitis;
- post-traumatic inflammation of soft tissues and the musculoskeletal system (damage and rupture of ligaments, bruises);
- pain syndrome of various origins (including postoperative period, for injuries, algodismenorrhea, toothache, headache);
- fever of various origins (including infectious and inflammatory diseases).
Release forms
Tablets 100 mg.
Dispersible tablets 50 mg (can be used to prepare a suspension or syrup by dissolving in water, this form is convenient for use in children).
Gel for external use 1%.
Instructions for use and dosage
Pills
Adults are prescribed 100 mg orally 2 times a day. Maximum daily dose- 400 mg.
It is preferable to take the drug in the form of a suspension before meals, but if you feel discomfort in the stomach, you can take it at the end or after a meal.
The drug in the form of dispersible tablets should be taken at the end or after meals. Before taking, 1 tablet is dissolved in 5 ml (1 teaspoon) of water.
For children over 2 years of age, the drug is prescribed in the form of a suspension, for children over 3 years of age - in the form of dispersible tablets or suspensions, for children over 12 years of age, the drug can be prescribed in the form of tablets (100 mg 2 times a day). The recommended dose is 3-5 mg/kg body weight 2-3 times a day. Maximum dose- 5 mg/kg per day in 2-3 doses. For adolescents weighing more than 40 kg, the drug is prescribed 100 mg 2 times a day.
The maximum dose is 5 mg/kg body weight per day. The duration of use of the drug is 10 days.
Gel
Before using the gel, wash and dry the skin surface. Apply a strip of gel approximately 3 cm long in an even thin layer, without rubbing, to the area of maximum pain 3-4 times a day.
The amount of gel and the frequency of its use (no more than 4 times a day) varies depending on the size of the skin area being treated and the patient’s reaction.
The maximum dose is 5 mg/kg per day (30 g per day). The duration of use of the drug is no more than 10 days without consulting a doctor.
Side effect
- heartburn;
- nausea, vomiting;
- pain in the stomach;
- diarrhea;
- erosive and ulcerative lesions of the gastrointestinal tract;
- headache;
- dizziness;
- thrombocytopenia, leukopenia, anemia, agranulocytosis;
- skin rash;
- anaphylactic shock;
- bronchospasm;
- fluid retention;
- prolongation of bleeding time;
- hematuria (blood in the urine);
- when applying the gel - itching, urticaria, peeling, transient change in skin color (does not require discontinuation of the drug).
Contraindications
- erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
- bleeding from the gastrointestinal tract;
- "aspirin triad";
- liver dysfunction;
- severe renal failure (CK<30 мл/мин);
- pregnancy;
- lactation (breastfeeding);
- dermatoses, damage to the epidermis, skin infections in the area of application (for gel);
- children under 2 years of age;
- hypersensitivity to nimesulide and other components of the drug, acetylsalicylic acid and other NSAIDs.
Use during pregnancy and breastfeeding
Nise is contraindicated for use during pregnancy.
If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.
Special instructions
Nise should be prescribed with caution to patients with impaired renal function and visual impairment.
With long-term use, it is necessary to monitor liver and kidney functions.
When using the drug in elderly patients, no dosage adjustment is required.
Impact on the ability to drive vehicles and operate machinery
Due to the fact that Nise, when taken orally, can cause dizziness and drowsiness, the drug should be prescribed with caution to patients engaged in potentially hazardous activities that require increased concentration and rapid psychomotor reactions.
Drug interactions
Manifestations of drug interactions are possible (due to competition between drugs for binding to proteins) when taking Nise orally with digoxin, phenytoin, lithium drugs, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, and oral hypoglycemic agents.
Analogues of the drug Nise
Structural analogues of the active substance:
- Actasulide;
- Ameolin;
- Aponil;
- Aulin;
- Cockstral;
- Mesulide;
- Nemulex;
- Nimegesik;
- Nimesil;
- Nimesulide;
- Nimesulide-Pharmaplant;
- Nimika;
- Nimulid;
- Novolid;
- Prolid;
- Sulaydin;
- Flolide.
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
Nise gel is a drug for topical use, which belongs to the anti-inflammatory group of non-steroidal drugs. The medication is successfully used in the treatment of diseases of an inflammatory nature, bursitis, tendovaginitis, osteoarthritis, and osteoarthritis. The medicine can be purchased in the form of a gel, ointment or cream. It has anti-inflammatory, antipyretic and analgesic effects.
- thimerosal;
- propylene glycol;
- flavorings;
- pyrrolidone;
- isopropanol;
- potassium phosphate;
- macrogol;
- 940 carbomer.
- radiculitis;
- inflammation of tendons, sciatic nerve, ligaments;
- chondrosis;
- osteoarthritis;
- rheumatism and gout;
- ankylosing spondylitis;
- joint disease due to psoriasis and rheumatoid nature;
- pain in ligaments and muscles due to injury.
- anemia;
- fluid retention;
- burning behind the sternum and in the larynx;
- nausea and vomiting;
- digestive disorders;
- the occurrence of erosions and small ulcers on the mucous membrane;
- thrombocytopenia;
- headache, migraine and feeling of dizziness;
- change in blood test;
- the occurrence of allergies, in rare cases anaphylactic shock;
- development of liver transaminase activity.
- hypersensitivity to one of the components of the gel;
- acute damage to the digestive system by ulcers or erosions;
- stomach/intestinal bleeding;
- dermatoses of various etiologies, damage to the upper layers of the epidermis;
- infectious skin diseases;
- acute renal failure;
- pathological processes in the hematopoietic system;
- history of bronchospasms caused by the use of other anti-inflammatory drugs.
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Release form and composition
The drug is produced in tubes of 20 g and 50 g. It is in cardboard packages. The medicine is free from foreign particles and has a yellow, transparent or light yellow color.
1 g of the medicine contains 10 mg of the active ingredient nimesulide.
The composition of Nise gel, cream and ointment includes the following excipients:
Pharmacology
This anti-inflammatory drug is of non-steroidal origin and belongs to the sulfonanilide type. Nimesulide is the active element of the drug, which has antipyretic, analgesic and anti-inflammatory effects. This action is due to the selective shutdown of 2-cyclooxygenase.
Methanol has antipruritic, antiseptic, analgesic, sedative and local thinning effects. The effect of the drug is associated with reflexes that appear due to irritating effects on the mucous membranes and nerve endings of the receptors. The medicine releases and produces elements that are actively involved in vascular permeability and the regulation of pain. They provide antipruritic and distracting effects.
External and local use of the product is accompanied by a feeling of coldness and vasoconstriction. It turns into a tingling and burning effect. These processes improve vascular tone and tissue trophism.
Methyl salicylate is hydrolyzed, actively penetrates, is absorbed and converted into the salicylic acid anion. The substance reduces the production of prostaglandins and lowers cyclooxygenase. These elements are responsible for increased body temperature, soreness, inflammation and swelling. Methyl salicylate reduces pain in tissues, muscles and joints, normalizes capillary permeability.
Indications
Indications for use of Nise gel, ointment or cream - relief of inflammation and pain. The medication is used in the following cases:
Directions for use
Nise gel, cream and ointment are prescribed externally only. It is necessary to follow the dosage prescribed by the attending physician and indicated in the instructions for use. Before starting the procedure, you need to prepare the affected area. It must be dry and clean. It is necessary to squeeze out the product no more than 2 cm long. The medicine is applied to the sore spot with gentle movements and a thin layer.
The medication is allowed to be used no more than four times a day. The duration of therapy is 14 days. If after 10 days there is no positive effect from therapy, you should consult your doctor.
The drug is not recommended for use if there is damage to the skin. A few minutes after applying the ointment, gel or cream, a burning sensation may be observed. Do not allow the medicine to come into contact with mucous membranes or eyes.
For joint diseases, it must be used during a period of complete or unstable remission.
Side effects and overdose
When using Nise ointment, cream or gel, adverse reactions may occur. Quite rarely, hives, burning sensations, changes in skin color, itching, swelling or peeling occur. With such symptoms, the drug is not canceled, as they go away on their own after a few days.
If you use the medicine for a long time, the following reactions may occur:
In such cases, it is necessary to discontinue the drug and consult your doctor for advice and change the treatment regimen.
No cases of drug overdose with Nise have been identified. Negative side effects may occur due to an exceeded dosage of 50 g. There is no official antidote, so if side effects develop, it is necessary to call an ambulance and begin symptomatic treatment.
Contraindications
Contraindications include the following conditions:
The drug should not be used by pregnant women. If they have joint pain, they should consult their doctor for advice. He will prescribe similar remedies. Breastfeeding must be stopped during treatment.
1. Pharmacological action
An anti-inflammatory drug of non-steroidal origin for external use, which has an analgesic effect.2. indications for use
- Various rheumatoid;
- Various inflammatory diseases of the joints and articular components;
- Inflammatory diseases of peripheral nerves;
- Inflammatory diseases of soft tissues due to trauma.
3. Method of application
- Recommended dosage: apply a thin layer of the drug to the affected area of the body, without rubbing, no more than four times a day;
- Maximum dosage: 30 g of the drug per day;
- Recommended duration of treatment: no more than ten days.
- After use, wash your hands well with detergent;
- Should only be used on undamaged areas of the skin;
- Use in patients suffering from functional disorders of the liver or kidneys should be used with caution.
4. Side effects
- Central nervous system: dizziness, headaches;
- Urinary system: the appearance of blood in the urine, fluid retention;
- Skin damage: change in skin color, itching at the site of application;
- Digestive system: nausea, pain in the stomach, ulcerative lesions of the digestive system, increased activity of liver enzymes, erosive lesions of the digestive system, heartburn, vomiting;
- Hematopoietic system: decreased number of leukocytes, increased number of agranulocytes, decreased number of platelets, decreased amount of hemoglobin, prolongation of bleeding time;
- Hypersensitivity reactions to Nise gel: skin rashes.
5. Contraindications
- Use of Nise gel during pregnancy;
- Infectious diseases of the skin at the site of application;
- Hypersensitivity to Nise gel or its components;
- The presence of dermatoses at the site of application of Nise gel;
- Individual intolerance to Nise gel or its components;
- Damage to the skin at the site of application;
- Use of Nise gel during breastfeeding.
6. During pregnancy and lactation
During pregnancy, the use of Nise gel is contraindicated.During lactation, the use of Nise gel is contraindicated.
7. Interaction with other drugs
The simultaneous use of Nise gel with Digoxin, drugs containing lithium, drugs that lower blood pressure, blood thinning drugs, Methotrextat, Phenytoin, diuretics, non-steroidal anti-inflammatory drugs, Cyclosporine or glass melting drugs that lower blood glucose levels leads to the occurrence of drug interactions due to competition of the listed drugs with Nise gel for protein binding.8. Overdose
Cases of overdose with Nise gel have not been described.9. Release form
Gel for external use, 1% - 20 or 50 g.10. Storage conditions
Nise gel is stored out of reach.11. Composition
One gram of Nise gel:- 10 mg nimesulide;
- 50 mg menthol;
- 100 mg methyl salicylate;
- 250 mcg capsaicin.
12. Conditions for dispensing from pharmacies
The drug is available without a prescription.Found a mistake? Select it and press Ctrl + Enter
* Instructions for medical use of the drug Nise gel are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, YOU MUST CONSULT WITH A SPECIALIST
