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What is Nise ointment for? "Nise Gel" - instructions, composition, method of application

Self-medication can be harmful to your health.
You should consult your doctor and read the instructions before use.

Nise gel: instructions for use

Compound

1 g contains: nimesulide 10 mg

methyl salicylate 100 mg menthol 50 mg

capsaicin 0.25 mg

excipients: diethyl phthalate 50 mg, diethylene glycol monoethyl ether 50 mg, hydrogenated polyoxycastor oil 50 mg, propylene glycol 70 mg, sodium benzoate 1 mg, disodium EDTA 1 mg, butylated hydroxytoluene 0.4 mg, carbomer-980 12 mg, trometamol 2 mg, water.

Description

Pharmacological action

1. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) from the sulfonanilide class, has analgesic, anti-inflammatory and antipyretic effects.

The effect is due to the selective blockade of cyclooxygenase-2, as well as a number of other mechanisms, such as:

Suppression of platelet activating factor synthesis;

Decreased production of superoxide anion by stimulated

polymorphonuclear leukocytes through suppression of protein kinase C and phosphodiesterase type IV.

Prevention of bradykinin and cytokine-induced hyperalgesia by inhibiting the release of tumor necrosis factor a.

Neutralization of hypochloric acid

Prevention of inactivation of a-proteinase inhibitors.

Inhibition of proteases (including elastase, collagenase)

Inhibition of histamine release from basophils and mast cells

Slowing down the degradation of the cartilage matrix by inhibiting the synthesis of metalloproteases.

2. Menthol has a local irritant, analgesic, distracting, antipruritic, antiseptic, and sedative effect. The effect is mainly due to reflex reactions associated with irritation of sensitive nerve endings: irritation of skin or mucous membrane receptors stimulates the formation and release of endogenous biologically active substances (enkephalins, endorphins, peptides, kinins) involved in the regulation pain, vascular permeability and other processes, providing analgesic, distracting and antipruritic effects. Antiseptic activity
manifests itself as indiscriminate damage to microbial cells. The irritating (distracting) effect helps reduce pain. Local action accompanied by constriction of blood vessels, a feeling of cold, turning into a feeling of slight burning and tingling. Skin-visceral reflexes (the reflex arc does not affect the brain) improve tissue trophism (according to the innervation zones). Reflexively changes the tone of blood vessels, both superficial and deep in tissues and internal organs.

3. Capsaicin has an effect by reducing the content of substance P, which is a neurotransmitter that carries out pain and itching reactions from peripheral receptors nervous system to the central one. Capsaicin blocks the synthesis and transmission of substance P along the neuron, which leads to a decrease in the intensity of the pain impulse.

4. Methyl salicylate - derivative salicylic acid. When applied locally, it quickly penetrates into the deep layers of the skin, is absorbed, hydrolyzed and converted into salicylic acid anion. Non-selectively inhibits cyclooxygenase, reduces the synthesis of prostaglandins responsible for inflammation, pain, and fever. Normalizes increased capillary permeability, improves microcirculation processes, reduces swelling and infiltration of inflamed tissues, causes a decrease in pain in pathologies of joints, muscles and soft tissues. It has a local irritant effect on the skin, which helps reduce pain.

Pharmacokinetics

Nimesulide: according to international studies, the maximum

the concentration of nimesulide in the blood plasma after a single local application at a dose of 200 mg is observed 24 hours after application and reaches 9.77 ng/ml. Metabolized in the liver. No traces of the main metabolite of nimesulide, 4-hydroxynimesulide, were detected in plasma. At long-term use The concentration of nimesulide on day 8 in the blood plasma was 37.25 + 13.25 ng/ml, which is 100 times less than when taken orally at an average daily dose (200 mg/day).

Due to insignificant systemic absorption, data on the pharmacokinetics of the remaining active components at local application are missing.

Indications for use

Spicy and chronic diseases musculoskeletal system, accompanied by pain and inflammatory syndromes, including extra-articular rheumatic diseases, soft tissue bruises, pain in the lower back, tendinitis, tenosynovitis, sprains.

Pregnancy and lactation

Nimesulide is not used in pregnant and lactating women. Studies confirming its effectiveness and safety during pregnancy and lactation have not been conducted. There is no data on the effect on fetal development.

Directions for use and doses

For external use only.

The gel (in an amount corresponding to the length of a column of 3 cm) is carefully applied in a thin layer to the painful area 3-4 times a day or as directed by a doctor.

Rinse thoroughly and dry the skin area before application. Apply a thin layer of gel to the corresponding area and surrounding area, rub in light movements. It is recommended to avoid wearing constrictive clothing. Before and after the procedure, wash your hands with soap. It is not recommended to use more than 1 tube per day

Usually the course of treatment lasts 7-15 days. If necessary, repeated courses of treatment are recommended after 3-5 days.

Side effect

Topically applied nimesulide preparations are usually well tolerated.

Observed side effects include moderate or severe local irritative reactions, hyperemia, rash, desquamation, itching and associated reactions in the area of application of the drug, as a manifestation hypersensitivity to the components of the drug.

Capsaicin, which is part of the drug, in a concentration of 1% or more can cause neurotoxicity and thermal hyperalgesia, a burning sensation, and redness.

In case of adverse reactions it is necessary to stop using the drug and prescribe appropriate treatment.

No systemic adverse reactions were observed when using the drug.

Overdose

no cases of overdose with local use have been described. When applying more than 50 g to large areas of skin, an overdose (systemic adverse reactions) may develop. It is recommended to consult a doctor. There are no specific antidotes.

Interaction with other drugs

Local use of nimesulide does not cause clinically significant effects on the metabolism of other drugs.

Features of application

Do not apply the gel around the eyes, on mucous membranes, on healthy areas of the body, on wound surfaces. Do not use for dermatitis. Do not touch sensitive areas of the skin with your hands containing the gel. Avoid using the gel with airtight dressings. After applying the gel, wash your hands with soap.

After completely rubbing the drug in, redness and burning may occur. These symptoms usually go away within a few days after stopping the drug.

The drug should be used with caution in patients with increased risk development side effects associated with the intake of salicylates.

Use in pediatrics

Effect of use on drivers and workers associated with machinery:

Patients taking nimesulide orally should be warned about its side effect- dizziness. Use with caution while driving and working. No cases of dizziness have been described after topical application of nimesulide.

Mutagenicity and carcinogenicity:

In various studies, nimesulide turned out to be a non-mutagenic drug.

There is also no data on the effect of the drug on the chromosomes of lymphocytes in vitro, and the interaction with H-thymidine of cultured human lymphocytes.

Ointment Nise used to treat diseases of the joints and muscles, helps restore motor activity. It is easy to use and effective. Nise ointment is a popular remedy that is in every home medicine cabinet. This is a nonsteroidal anti-inflammatory drug (NSAID) that quickly and effectively eliminates pain in the limbs and spine and has virtually no side effects.

The ointment contains several active components that penetrate well to the site of inflammation and do not have a systemic effect on the body.

The drug is produced in the form of a yellow-gray gel, uniform in consistency. Aluminum tubes, volume – 20 and 50 g.

Nise ointment as main medicinal component contains nimesulide, related to to the last generation NSAIDs.

Composition of 1 g of the drug:

nimesulide – 10 mg;
methylpyrrolidone – 250 mg;
propylene glycol – 100 mg;
isopropanol – 100 mg;
water – 200 mg;
other components.

The name Nise is also used for tablets containing the same active ingredient nimesulide. Nimesulide content – 100 mg. Dispersing tablets quickly dissolve in the mouth and have a pronounced antipyretic effect. In addition, they eliminate inflammation, soreness of muscles and joints.

Appointed to complex therapy with ointment for faster relief of painful processes.

Nise tablets are available in blisters of 10 pcs.

Indications for use

Nimesulide belongs to the same group non-steroidal drugs, as Paracetamol, Ibuprofen.

For information: Nise belongs to a new generation of synthetic drugs (NSAIDs) of the sulfonanilide group.

Ointment, thanks to good absorption through skin, has a pronounced analgesic effect, relieves inflammation well. Nimesulide reduces the amount of prostaglandins at the site of inflammation, reduces the ability spinal cord pass pain impulses. This leads to a decrease in the synthesis of mediators inflammatory process, reduces its severity.

The new generation of NSAIDs acts on the body more selectively, without suppressing the production of COX-1, which was typical for other drugs in this group.

After applying Nise, the components quickly penetrate into the muscles and joint fluid, suppressing the action of COX-2, which helps reduce inflammatory mediators. Correct regulation of the action of two enzymes (COX-1 and COX-2) in the body is the main advantage of nimesulide.

This is the quality drug Nise distinguishes it favorably from other non-steroidal external agents, the use of which often produced many side effects.

The result of using the ointment is a decrease pain syndrome and swelling, reverse development of inflammation, return of joint mobility, increased muscle elasticity.

Let's look at what application helps with gel Nise what pathologies are treated with its help:

arthritis – rheumatoid, psoriatic;
osteoarthritis;
radiculitis;
osteochondrosis;
inflammation of soft tissues, muscles, ligaments, including traumatic ones;
muscle pain of various types;
sciatica;
lumbago;
gout;
bursitis;
spondyloarthritis (Bechterew's disease);
myositis;
neuralgia;
tenosynovitis;
arthralgia;
synovitis

The ointment is a first aid remedy for injuries, inflammatory and degenerative pathologies of the musculoskeletal system.

Nimesulide metabolites are almost not present in the blood after using the ointment. Nise for external use practically does not enter the bloodstream, which makes the drug safe for use.

Instructions for use and dosage

The ointment is used externally.

Instructions for using Nise ointment:

The area of skin before applying Nise is washed clean water, washing away dirt and remnants of previously used medications.
Take 1-3 cm of ointment. The drug should lie on the skin in a thin layer. The volume of medication is chosen depending on the size of the painful area.
Lubricate the projection of the spine or joint without rubbing, with light movements and patting until the product dries.
You need to wash your hands well when finished, removing any remaining Nise ointment. Protect eyes and mucous membranes from contact with the product.
Allowed to use 3-4 times a day.
Duration of use – up to 10 days.

A longer course must be agreed with your doctor. If there is no improvement, the drug will have to be changed after consultation with a specialist.

Nise tablets can be prescribed in complex treatment with ointment.

Contraindications

skin damage at the application site - infectious, allergic, wounds;
gastrointestinal pathologies - ulcerative, bleeding;
liver and kidney failure;
severe reactions to other NSAID drugs (bronchospasm);
during pregnancy and breastfeeding;
children under 7 years old.

The ointment requires supervision when used when cardiovascular pathologies, severe forms hypertension, diabetes mellitus without insulin dependence, as well as in elderly patients.

If there are known reactions to Aspirin, Paracetamol and other NSAID medications, you should inform your doctor when prescribing.

The negative effects of the ointment can manifest themselves in the form of skin reactions - itching, slight swelling of the skin, changes in pigmentation, peeling. If possible, the dose should be reduced; discontinuation is not required.

Possible systemic reactions:

headache;
dyspeptic symptoms – diarrhea, nausea, vomiting;
allergic manifestations (up to anaphylactic shock);
the appearance of gastrointestinal ulcers, bleeding;
anemia;
increased blood content in urine;
thrombocytopenia;
increased duration of bleeding;
leukopenia.

You should inform your doctor about any changes in your condition due to the use of Nise ointment.

Interaction

When prescribing Nise, you should warn your doctor about taking other medications. Possible interaction with the following groups of drugs:

antihypertensive;
diuretics;
hypoglycemic;
products with lithium;
Cyclosporine;
Digoxin;
NSAIDs.

The doctor may, if necessary, choose another treatment.

Price

The cost of a package of Nise gel: 20 g – from 150 rubles, 50 g – from 270 rubles.

Analogs

Nimesulide – active ingredient ointments included in the following medicines local use:

Nimulid. Available in the form of a light texture gel. Has a volume of 10, 20, 30 g. Contents active substance– 1%. Made in India. It has the same scope and features of application. Price – from 130 rubles.

It must be remembered that all analogues differ from the original in the accompanying components, so you need to consult a doctor about replacement. Each remedy has its own contraindications and negative effects.

In this article you can find instructions for use medicinal product Nise. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Nise in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Nise in the presence of existing structural analogues. Use for the treatment of pain and inflammation in joints and muscles in adults, children, as well as during pregnancy and breastfeeding.

Nise- non-steroidal anti-inflammatory drug. Selective inhibitor of COX-2 - an enzyme involved in the synthesis of prostaglandins - mediators of edema, inflammation and pain. The drug has anti-inflammatory, analgesic and antipyretic effects.

Reversibly inhibits the formation of prostaglandin E2, both at the site of inflammation and in the ascending pathways of the nociceptive system, including the pathways of pain impulses in the spinal cord.

Reduces the concentration of short-lived prostaglandin H2, from which prostaglandin E2 is formed under the action of prostaglandin isomerase. A decrease in the concentration of prostaglandin E2 leads to a decrease in the degree of activation of EP-type prostanoid receptors, which is expressed in analgesic and anti-inflammatory effects.

It has a slight effect on COX-1 and practically does not interfere with the formation of prostaglandin E2 from arachidonic acid in physiological conditions, thereby reducing the number of side effects of the drug.

Nise suppresses platelet aggregation by inhibiting the synthesis of endoperoxides and thromboxane A2, and inhibits the synthesis of platelet aggregation factor. Suppresses the release of histamine and also reduces the degree of bronchospasm caused by exposure to histamine and acetaldehyde.

It has been shown that nimesulide ( active substance drug Nise) is able to suppress the synthesis of interleukin-6 and urokinase, thereby preventing the destruction cartilage tissue. Inhibits the synthesis of metalloproteases (elastase, collagenase), preventing the destruction of proteoglycans and collagen of cartilage tissue.

It has antioxidant properties and inhibits the formation of toxic oxygen breakdown products by reducing the activity of myeloperoxidase. Interacts with glucocorticoid receptors, activating them through phosphorylation, which also enhances the anti-inflammatory effect of the drug.

When applied topically, it causes a weakening or disappearance of pain at the site of application of the gel, incl. pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints. Helps increase range of motion.

Pharmacokinetics

After oral administration, Nise is well absorbed from the gastrointestinal tract. Eating reduces the rate of absorption without affecting its extent. Penetrates into the tissues of the female genital organs, where after a single dose the concentration of nimesulide is about 40% of the concentration in plasma. Penetrates well into the acidic environment of the inflammation site (40%), synovial fluid(43%). Easily penetrates histo-hematological barriers. The metabolite is excreted by the kidneys (65%) and bile (35%).

Indications

rheumatoid arthritis;
articular syndrome with rheumatism and exacerbation of gout;
psoriatic arthritis;
ankylosing spondylitis;
osteochondrosis with radicular syndrome;
radiculitis;
sciatica;
lumbago;
osteoarthritis;
arthritis of various etiologies;
arthralgia;
myalgia of rheumatic and non-rheumatic origin;
inflammation of ligaments, tendons, bursitis;
post-traumatic inflammation of soft tissues and the musculoskeletal system (damage and rupture of ligaments, bruises);
pain syndrome of various origins(including in postoperative period, for injuries, algodismenorrhea, toothache, headache);
fever of various origins (including infectious and inflammatory diseases).

Release forms

Tablets 100 mg.

Dispersible tablets 50 mg (can be used to prepare a suspension or syrup by dissolving in water, this form is convenient for use in children).

Gel for external use 1%.

Instructions for use and dosage

Pills

Adults are prescribed 100 mg orally 2 times a day. Maximum daily dose- 400 mg.

It is preferable to take the drug in the form of a suspension before meals, but if you feel discomfort in the stomach, you can take it at the end or after a meal.

The drug in the form of dispersible tablets should be taken at the end or after meals. Before taking, 1 tablet is dissolved in 5 ml (1 teaspoon) of water.

For children over 2 years of age, the drug is prescribed in the form of a suspension, for children over 3 years of age - in the form of dispersible tablets or suspensions, for children over 12 years of age, the drug can be prescribed in the form of tablets (100 mg 2 times a day). The recommended dose is 3-5 mg/kg body weight 2-3 times a day. Maximum dose- 5 mg/kg per day in 2-3 doses. For adolescents weighing more than 40 kg, the drug is prescribed 100 mg 2 times a day.

The maximum dose is 5 mg/kg body weight per day. The duration of use of the drug is 10 days.

Gel

Before using the gel, wash and dry the skin surface. Apply a strip of gel approximately 3 cm long in an even thin layer, without rubbing, to the area of maximum pain 3-4 times a day.

The amount of gel and the frequency of its use (no more than 4 times a day) varies depending on the size of the skin area being treated and the patient’s reaction.

The maximum dose is 5 mg/kg per day (30 g per day). The duration of use of the drug is no more than 10 days without consulting a doctor.

Side effect

heartburn;
nausea, vomiting;
pain in the stomach;
diarrhea;
erosive and ulcerative lesions of the gastrointestinal tract;
headache;
dizziness;
thrombocytopenia, leukopenia, anemia, agranulocytosis;
skin rash;
anaphylactic shock;
bronchospasm;
fluid retention;
prolongation of bleeding time;
hematuria (blood in the urine);
when applying the gel - itching, urticaria, peeling, transient change in skin color (does not require discontinuation of the drug).

Contraindications

erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
bleeding from the gastrointestinal tract;
"aspirin triad";
liver dysfunction;
pronounced renal failure(QC<30 мл/мин);
pregnancy;
lactation (breastfeeding);
dermatoses, damage to the epidermis, skin infections in the area of application (for gel);
children under 2 years of age;
hypersensitivity to nimesulide and other components of the drug, acetylsalicylic acid and other NSAIDs.

Use during pregnancy and breastfeeding

Nise is contraindicated for use during pregnancy.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Special instructions

Nise should be prescribed with caution to patients with impaired renal function and visual impairment.

With long-term use, it is necessary to monitor liver and kidney functions.

When using the drug in elderly patients, no dosage adjustment is required.

Impact on the ability to drive vehicles and operate machinery

Due to the fact that Nise, when taken orally, can cause dizziness and drowsiness, the drug should be prescribed with caution to patients engaged in potentially hazardous activities that require increased concentration and rapid psychomotor reactions.

Drug interactions

Manifestations of drug interactions are possible (due to competition between drugs for binding to proteins) when taking Nise orally with digoxin, phenytoin, lithium drugs, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, and oral hypoglycemic agents.

Analogues of the drug Nise

Structural analogues of the active substance:

Actasulide;
Ameolin;
Aponil;
Aulin;
Cockstral;
Mesulide;
Nemulex;
Nimegesik;
Nimesil;
Nimesulide;
Nimesulide-Pharmaplant;
Nimika;
Nimulid;
Novolid;
Prolid;
Sulaydin;
Flolide.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Painful sensations, regardless of their origin, cause a lot of inconvenience to a person. The situation is aggravated if the problem is localized in the area of soft tissues and joints. In such cases, the body becomes stiff, and every movement causes pain.

What to do, who to turn to for help, and is it possible to get rid of these symptoms at all? It turns out that the simplest and most effective way to solve the problem is right in front of your eyes - instructions for using Nise Gel.

Nise gel is a local non-steroidal medicine that helps cope with pain and fever in diseases of various etiologies. It is actively used in the treatment of bursitis, osteoarthritis, tendovaginitis, osteoarthritis, as well as a number of other inflammatory ailments. The drug has become widespread among both doctors and patients.

Nice gel features:

Clinical studies have confirmed that the medication is absolutely safe.
A nominal amount of active substances penetrates through the surface of the skin into the main bloodstream.
The maximum concentration in the body is formed only 24 hours after using the gel.
The drug composition does not affect the chemical composition of blood plasma.

The medication does not accumulate in tissues, joints or internal organs, but is completely eliminated through the liver.

Pharmacological group and action

Nise ointment belongs to a large pharmacological group of topical nonsteroidal anti-inflammatory drugs (sulfonanilide class) (NSAIDs). After application to a problem area of the body, it eliminates inflammatory processes in joints and soft tissues, and relieves painful symptoms. The main active ingredient of the drug is nimesulide, which causes a therapeutic, analgesic effect.

Mechanism of action of the drug:

Prevents the synthesis of prostaglandin at the site of the inflammatory process (without this element the formation of edema and painful sensations is impossible).
Inhibits COX, acting selectively on problem areas. In rare cases, it affects healthy cells.
Menthol in the composition of the medication helps to activate cold receptors, resulting in a calming effect.
Joint and bone tissue are nourished in the form of calcium ions, thanks to which the affected area is quickly saturated with nutrients and oxygen.

Methyl salicylate increases the intensity of blood flow at the site of application (after hydrolysis), suppresses biochemical processes associated with the formation of edema and severe pain (including lipid oxidation). Due to which there is a local anti-inflammatory and analgesic effect, the amplitude and range of movements gradually increases

Release form and composition

The pharmaceutical drug is available in the form of a white translucent gel (for some manufacturers the color is shifted towards yellow tones). It is a homogeneous, medium-thick consistency without any foreign inclusions or substances. Available for sale in aluminum tubes of 20 and 50 g. Supplied in a separate cardboard box with annotation.

The composition of the Nice gel includes 4 active substances (per 1 g of product):

A number of excipients are also present: thimerosal, macrogol, isopropanol, carbomer 940, propylene glycol.

Storage conditions and shelf life of the drug

The gel is prescribed to be stored in a dark place at a temperature of 24 °C; it is important to avoid contact of the aluminum tube with direct sunlight and sources of moisture. When placed in the refrigerator and frozen, the drug loses its declared properties.

The shelf life in a sealed tube, subject to the above requirements, is 24 months from the date of manufacture indicated on the cardboard box. If the tube is damaged, the thickness of the consistency, color changes, or a pronounced odor appears, use of the medicine is strictly prohibited!

Instructions for use

It is necessary to use a pharmaceutical drug for the treatment of joint pain as prescribed by a doctor. When using the composition yourself, it is important to read in detail the instructions for applying the Nise gel. To achieve the desired effect, it is recommended to strictly adhere to the indicated dosage and frequency of procedures.

There is only one method of use for the drug - external, local.

Step by step instructions:

The area where the gel is applied is washed with soap and water, if possible treated with an antiseptic, and wiped dry with a towel.
The medicinal composition is applied only to “clean” skin, without inflammation, damage or ulcers.
The recommended amount of gel for application to the surface of the skin is up to 3 cm (3 g) for 1 procedure.
The consistency of medium thickness is evenly distributed over the problem area, forming a thin layer of coating. Healthy skin is not treated!
It is forbidden to rub the drug into the epithelium; the absorption process occurs naturally without outside intervention.
An anti-inflammatory, antipyretic agent is applied 1-3 times a day (every 8-12 hours), every day (no more than 10 days).

After applying the medication to the surface of the skin, it may cause itching and burning. It stops without patient intervention after 2-4 minutes. The duration of treatment is determined by the doctor, based on the characteristics of the pathology and accompanying symptoms.

Indications for use

A feature of the Nise gel is its wide spectrum of action. It is used to combat ailments of the musculoskeletal system, relieving painful sensations that develop against the background of elevated body temperature.

Main indications for use:

Nise ointment is often prescribed for bruises, injuries, bruises, inflammations localized in cartilage and bone tissue.

Contraindications and side effects

There is not a single pharmaceutical drug that does not have contraindications. Nise gel also has restrictions on its use.

It is prohibited to apply the composition when:

open wounds, active inflammatory processes accompanied by purulent discharge;
severe renal failure;
high sensitivity to active or auxiliary substances;
internal bleeding localized in the stomach area;
extensive lesions of the digestive tract with ulcers;
problems with blood formation;
children under 7 years of age.

Elderly patients diagnosed with hypertension, diabetes mellitus (type 2), and pathologies of the cardiovascular system should exercise extreme caution when applying the medicine.

Overdose is often accompanied by side effects (despite the lack of officially confirmed data):

migraine attacks;
erosive formations on the gastric mucosa;
nausea followed by vomiting;
burning;
problems with blood formation;
severe allergic reactions;
local swelling;
dizziness.

If after taking the medication the patient experiences an unpleasant sensation or one of the side effects, the subsequent use of the medication should be discontinued. It is equally important to seek medical help promptly.

Use during pregnancy and lactation

Pregnant women are strictly prohibited from applying Nise Gel. To prevent joint pain, substitutes or analogues are used as prescribed by a doctor. Similar restrictions are imposed during lactation. If there is an urgent need to use the particular composition in question, breastfeeding is stopped until the end of the therapeutic course.

Interaction with other drugs

Nise gel is used with extreme caution if the patient is already prescribed the following drugs: lithium-containing drugs, NSAIDs, digoxin, phenytoin, cyclosporine, hypoglycemic and antihypertensive drugs. It is imperative to notify the attending physician (if there are several, consult with each).

Directions for use and doses

Nise cream, in accordance with the instructions, is used exclusively externally. The safe dose when applying the composition is a strip 2.5-3 cm long. For children - 1.5-2 cm. Use the composition 3 to 4 times a day (children - 1 to 3 times). Treatment is limited in time to 10 days. If there is no positive dynamics within 7 days, it is recommended to consult a doctor for adjustment of the therapeutic course.

Special instructions

Nise ointment is applied only to clean and intact skin. It is important to avoid contact of the drug with open wounds and mucous membranes. It is strictly forbidden to take the medication orally.

A few important instructions:

The gel is not intended for children under 7 years of age.
Applying sealed and tight bandages with the medication in question is taboo.
After applying the thick consistency to the problem area, screw the tube cap tightly.
Before and after the procedure, hands are thoroughly washed with antibacterial soap.

It is safest to fight the disease under the supervision of a specialist. A personal treatment and therapy regimen must be prepared for each patient.

Nise gel - the latest description of the drug, you can read contraindications, side effects, dosage of the drug Nise gel. Reviews of Nise gel -

NSAIDs for external use.
Drug: NIZE®
Active substance of the drug: nimesulide
ATX encoding: M02AA
KFG: NSAIDs for external use
Registration number: P No. 012824/02
Registration date: 06.20.08
Owner reg. cred.: DR. REDDY`S LABORATORIES LTD. (India)

Nise gel release form, drug packaging and composition.

Gel for external use 1% is transparent, light yellow or yellow in color, free of foreign particles.

1 g
nimesulide
10 mg

Excipients: N-methyl-2-pyrrolidone, propylene glycol, macrogol, isopropanol, carbomer 940, butylated hydroxyanisole, thimerosal, potassium phosphate, water, flavor.

20 g - aluminum tubes (1) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

Pharmacological action Nise gel

NSAIDs for external use. It has a local analgesic and anti-inflammatory effect.

Nimesulide is a selective competitive reversible inhibitor of COX-2 (endoperoxide prostaglandin H2 synthetase). Reduces the concentration of short-lived prostaglandin H2, a substrate for kinin-stimulated synthesis of prostaglandin E2, at the site of inflammation and in the ascending pathways of pain impulses in the spinal cord.

A decrease in the concentration of prostaglandin E2 (a mediator of inflammation and pain) reduces the activation of EP type prostanoid receptors, which is manifested by analgesic and anti-inflammatory effects.

Pharmacokinetics of the drug.

Data on the pharmacokinetics of the drug are not provided.

Indications for use:

Articular syndrome with rheumatism and exacerbation of gout;

Rheumatoid arthritis;

Psoriatic arthritis;

Ankylosing spondylitis;

Osteoarthritis;

Osteochondrosis with radicular syndrome;

Radiculitis;

Inflammation of ligaments, tendons, bursitis;

Lumbago;

Myalgia of rheumatic and non-rheumatic origin;

Post-traumatic inflammation of soft tissues and the musculoskeletal system (damage and rupture of ligaments, bruises).

Dosage and method of administration of the drug.

Before using the gel, wash and dry the skin surface. Apply a strip of gel approximately 3 cm long in an even thin layer, without rubbing, to the area of maximum pain 3-4 times a day.

The amount of gel and the frequency of its use (no more than 4 times a day) varies depending on the size of the skin area being treated and the patient’s reaction.

The maximum dose is 5 mg/kg/day (30 g/day). The duration of use of the drug is no more than 10 days without consulting a doctor.

Side effects of Nise gel:

When applying the gel to large areas of the skin, systemic adverse reactions may develop.

From the digestive system: heartburn, nausea, vomiting, pain in the stomach, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, increased activity of liver transaminases.

From the side of the central nervous system: headache, dizziness.

From the hematopoietic system: thrombocytopenia, leukopenia, anemia, agranulocytosis, prolongation of bleeding time.

From the urinary system: fluid retention, hematuria.

Allergic reactions: skin rash, anaphylactic shock.

Local reactions: itching, urticaria, peeling, transient change in skin color (does not require discontinuation of the drug).

If any adverse reactions occur, you should stop using the drug and consult your doctor.

Contraindications to the drug:

Pregnancy;

Lactation period (breastfeeding);

Dermatoses, damage to the epidermis, skin infections in the area of application;

Hypersensitivity to nimesulide and other components of the drug.

The drug should be prescribed with caution for erosive and ulcerative lesions of the gastrointestinal tract, liver failure, renal failure (KK<30 мл/мин), застойной сердечной недостаточности, артериальной гипертензии, «аспириновой» астме, сахарном диабете типа 2 (инсулиннезависимом), у пациентов детского возраста младше 12 лет.

Use during pregnancy and lactation.

Nise is contraindicated for use during pregnancy and lactation.

Special instructions for use of Nise gel.

The drug should be applied only to intact areas of the skin, avoiding contact with open wounds. Avoid contact of the gel with the eyes and other mucous membranes, as well as use with airtight bandages.

After applying the gel, you should wash your hands with soap. The tube should be tightly closed after using the gel.

Drug overdose:

Currently, no cases of overdose of Nise have been reported.

When applying more than 50 g of gel to large areas of the skin, an overdose may develop (systemic adverse reactions).

There is no specific antidote. You should immediately consult a doctor.

Interaction of Nise gel with other drugs.

Manifestations of pharmacokinetic interaction are possible (due to competition between drugs for binding to proteins) while taking Nise orally with digoxin, phenytoin, lithium drugs, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, and oral hypoglycemic agents.