Nise gel- a recent description of the drug, you can read the contraindications, side effects, dosage of medicine Nise gel. Reviews of Nise gel -

NSAIDs for external use.
Drug: NIZE®
Active substance of the drug: nimesulide
ATX encoding: M02AA
KFG: NSAIDs for external use
Registration number: P No. 012824/02
Registration date: 06.20.08
Owner reg. cred.: DR. REDDY`S LABORATORIES LTD. (India)

Nise gel release form, drug packaging and composition.

Gel for external use 1% transparent, light yellow or yellow, free from foreign particles.

1 g
nimesulide
10 mg

Excipients: N-methyl-2-pyrrolidone, propylene glycol, macrogol, isopropanol, carbomer 940, butylated hydroxyanisole, thimerosal, potassium phosphate, water, flavor.

20 g - aluminum tubes (1) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

Pharmacological action Nise gel

NSAIDs for external use. It has a local analgesic and anti-inflammatory effect.

Nimesulide - selective competitive reversible inhibitor COX-2 (endoperoxide prostaglandin H2 synthetase). Reduces the concentration of short-lived prostaglandin H2, a substrate for kinin-stimulated synthesis of prostaglandin E2, at the site of inflammation and in the ascending pathways of pain impulses in the spinal cord.

A decrease in the concentration of prostaglandin E2 (a mediator of inflammation and pain) reduces the activation of EP type prostanoid receptors, which is manifested by analgesic and anti-inflammatory effects.

At local application causes a weakening or disappearance of pain at the site of application of the gel, incl. pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints. Helps increase range of motion.

Pharmacokinetics of the drug.

Data on the pharmacokinetics of the drug are not provided.

Indications for use:

Articular syndrome with rheumatism and exacerbation of gout;

Rheumatoid arthritis;

Psoriatic arthritis;

Ankylosing spondylitis;

Osteoarthritis;

Osteochondrosis with radicular syndrome;

Radiculitis;

Inflammation of ligaments, tendons, bursitis;

Lumbago;

Myalgia of rheumatic and non-rheumatic origin;

Post-traumatic inflammation of soft tissues and the musculoskeletal system (damage and rupture of ligaments, bruises).

Dosage and method of administration of the drug.

Before using the gel, wash and dry the skin surface. Apply a strip of gel approximately 3 cm long in an even thin layer, without rubbing, to the area of ​​maximum pain 3-4 times a day.

The amount of gel and the frequency of its use (no more than 4 times a day) varies depending on the size of the skin area being treated and the patient’s reaction.

The maximum dose is 5 mg/kg/day (30 g/day). The duration of use of the drug is no more than 10 days without consulting a doctor.

Side effects of Nise gel:

When applying the gel to large areas of skin, systemic symptoms may develop. adverse reactions.

From the outside digestive system: heartburn, nausea, vomiting, pain in the stomach, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, increased activity of liver transaminases.

From the side of the central nervous system: headache, dizziness.

From the hematopoietic system: thrombocytopenia, leukopenia, anemia, agranulocytosis, prolongation of bleeding time.

From the urinary system: fluid retention, hematuria.

Allergic reactions: skin rash, anaphylactic shock.

Local reactions: itching, urticaria, peeling, transient change in skin color (does not require discontinuation of the drug).

If any adverse reactions occur, you should stop using the drug and consult your doctor.

Contraindications to the drug:

Pregnancy;

Lactation period (breastfeeding);

Dermatoses, damage to the epidermis, skin infections in the area of ​​application;

Hypersensitivity to nimesulide and other components of the drug.

The drug should be prescribed with caution for erosive and ulcerative lesions of the gastrointestinal tract, liver failure, renal failure(QC<30 мл/мин), застойной сердечной недостаточности, артериальной гипертензии, «аспириновой» астме, сахарном диабете типа 2 (инсулиннезависимом), у пациентов детского возраста младше 12 лет.

Use during pregnancy and lactation.

Nise is contraindicated for use during pregnancy and lactation.

Special instructions for use of Nise gel.

The drug should be applied only to intact areas of the skin, avoiding contact with open wounds. Avoid contact of the gel with the eyes and other mucous membranes, as well as use with airtight bandages.

After applying the gel, you should wash your hands with soap. The tube should be tightly closed after using the gel.

Drug overdose:

Currently, no cases of overdose of Nise have been reported.

When applying more than 50 g of gel to large areas of the skin, an overdose may develop (systemic adverse reactions).

There is no specific antidote. You should immediately consult a doctor.

Interaction of Nise gel with other drugs.

Manifestations of pharmacokinetic interaction are possible (due to competition between drugs for binding to proteins) while taking Nise orally with digoxin, phenytoin, lithium drugs, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, and oral hypoglycemic agents.

Terms of sale in pharmacies.

The drug is approved for use as an over-the-counter product.

Storage conditions for the drug Nise gel.

List B. The drug should be stored out of the reach of children at a temperature not exceeding 25°C; do not freeze. Shelf life: 2 years.

Instructions

Nise gel is a medicine that has a local anesthetic effect. The drug has contraindications and side effects, so it must be used as prescribed by a doctor.

Nise gel is a medicine that has a local anesthetic effect.

Compound

1 g of gel contains:

• active ingredient - nimesulide (10 mg);
• propylene glycol;
• isopranol;
• potassium phosphate;
• distilled water;
• carbomer;
• flavoring

Pharmacological group

Mechanism of action

Pharmacodynamics

The drug has the following pharmacological properties:

1. Reduces the activity of type 2 cyclooxygenase, which is involved in the synthesis of prostaglandins. The drug prevents the accumulation of inflammatory mediators in the affected areas and nearby nerve endings.
2. Reduces the speed of pain impulses in the spinal cord.
3. Suppresses the activity of prostanoid receptors. This effect is explained by a decrease in the amount of prostaglandin E2. The drug has analgesic and anti-inflammatory effects.
4. Helps reduce the intensity or completely eliminate pain in areas of inflammation when applied externally. Relieves the feeling of stiffness, restores joint mobility, eliminates swelling.

Pharmacokinetics

When applied to small areas of the skin, nimesulide is absorbed into the blood slowly, it practically does not accumulate in the body.

What does Nise gel help with?

The drug is used for:

• inflammatory and degenerative changes in joints (arthritis and arthrosis);
• psoriatic lesions of the musculoskeletal system;
• Bekhterev's disease;
• gouty arthritis during exacerbation;
• sprains and inflammation of ligaments and tendons;
• osteochondrosis accompanied by radicular syndrome;
• sciatica and radiculitis;
• rheumatic lesions of soft tissues;
• rheumatoid arthritis;
• post-traumatic pain syndrome (after bruises, ligament ruptures and bone fractures).

Contraindications

Nise is not used for:

• individual intolerance to nimesulide and auxiliary ingredients of the gel;
• exacerbation of peptic ulcer of the stomach and duodenum;
• gastrointestinal bleeding;
• the presence of wounds, ulcers and cracks in the skin of the affected areas;
• bacterial, viral and fungal skin infections;
• dermatitis and dermatoses;
• bronchospasm that occurs when using non-steroidal anti-inflammatory drugs;
• decompensated diabetes mellitus;
• hypertensive crisis;
• acute heart failure.

How to apply Nise gel?

The gel is applied to intact areas of the skin located above the inflammatory focus. Before using the drug, the skin is washed and dried with a towel. 1-2 g of gel are evenly distributed over the area of ​​maximum pain. There is no need to rub the drug in. The procedure is repeated 3-4 times a day. The amount of gel used and the frequency of application depend on the area of ​​the affected area and the intensity of the discomfort. It is not recommended to be treated for more than 10 days without medical supervision.

For bruises

Before using Nise-gel for bruises, apply a cold compress, which reduces swelling and prevents the spread of hematoma. After applying the drug, the joint is fixed with a tight bandage and the injured limb is provided with rest.

For pain

For osteochondrosis

Before using the ointment, it is recommended to take a warm bath, which will facilitate the penetration of nimesulide into the site of inflammation. 2-3 g of the product is applied to the skin, rubbing in a circular motion. The back is covered with a woolen scarf. The procedures are carried out in the morning and evening.

Can the gel be used for children?

Nise is contraindicated for children under 7 years of age. When treating older patients, use caution.

Does Nise gel cause side effects?

When using Nise Gel, the following may occur:

• itching and burning of the skin;
• increased temperature in affected areas;
• transient redness of the skin that does not require cessation of treatment.

Treatment of large areas of skin may result in:

• nausea and vomiting;
• loose stools;
• swelling of the face and lower extremities;
• increased levels of ALT and AST;
• dizziness;
• blood in urine;
• signs of dysfunction of the hematopoietic system (decrease in the number of platelets, granulocytes and leukocytes);
• bleeding disorders;
• skin rashes like urticaria.

Overdose

There have been no cases of acute overdose of Nise gel. A single application of more than 50 g increases side effects. Treatment in this case is symptomatic.

Features of application

During pregnancy and lactation

The safety of the drug for the fetus and breastfed child has not been proven, therefore the gel is not recommended for use during pregnancy and lactation.

For impaired renal function

For liver dysfunction

For persons with severe liver failure, Nise is prescribed only for severe pain.

Drug interactions

With other drugs

It is not recommended to use Nise in combination with cardiac glycosides, lithium preparations, Cyclosporine, immunosuppressants and diuretics. The drug enhances the effectiveness of other NSAIDs. Nimesulide may suppress the effect of hypoglycemic and antihypertensive drugs.

Alcohol compatibility

Storage conditions and periods

The drug is kept in a dry, cool place, avoiding freezing. Shelf life is 24 months from the date of issue.

Conditions for dispensing from pharmacies

Is it sold without a prescription?

What is the price?

50 g of gel will cost 300-350 rubles.

Nise (tablets, gel, suspension) – instructions for use, analogues, reviews, price

Thank you

Nise is a non-narcotic anesthetic And antipyretic drug from the group of non-steroidal anti-inflammatory drugs (NSAIDs). Nise is used as a symptomatic drug as part of complex therapy for various conditions and diseases accompanied by elevated body temperature, pain and inflammation. The main areas of application of Nise are the treatment of osteoarthritis and osteoarthritis, as well as the relief of pain of various etiologies and localizations (for example, injuries, toothache, menstrual pain, diseases of the ear, nose and throat, etc.) and the reduction of body temperature during infections.

Names, varieties and forms of release

Currently, Nise is available in the following dosage forms:

• Tablets for oral administration;
• Dispersible tablets (soluble in a small amount of water) for oral administration;
• Suspension for oral administration;
• Gel for external use.

These dosage forms are conventionally considered varieties of the drug Nise. Of course, it is correct to classify the listed drug variants as different dosage forms, but for everyday use the term “varieties” is quite suitable, provided that all participants in the discussion mean the same thing by it.

Tablets for oral administration are simply called tablets or "Nise 100", and various terms are often used to refer to the suspension, such as syrup, solution and others, which are united by the fact that they imply a liquid dosage form intended for oral administration. The suspension is also called “Nise for children”, since this particular form of the drug is approved for use in children from 2 years of age. Dispersible tablets are sometimes called soluble tablets because they are intended to be taken orally after first dissolving in a small amount of water. These tablets differ from the usual ones in a lower dosage of the active substance, as well as a minimal risk of irritation of the gastric mucosa.

Gel for external use is often mistakenly called ointment. However, since Nise is not available in this dosage form, when people say “Nise ointment,” they mean the gel.

Nise - composition

As an active substance, all dosage forms of Nise include nimesulide in the following different dosages:

• Tablets for oral administration – 100 mg of nimesulide per tablet;
• Dispersible tablets – 50 mg of nimesulide per tablet;
• Suspension – 50 mg of nimesulide per 5 ml of solution;
• Gel – 1% (10 mg nimesulide per 1 g).

Excipients of all dosage forms of Nise are given in the table.

Auxiliary components of Nise tablets	Auxiliary components of Nise dispersible tablets	Auxiliary components of Nise suspension	Auxiliary components of Nise gel
Microcrystalline cellulose		Sucrose	Methyl salicylate
Cornstarch		Sorbitol	Diaethyl phthalate
Magnesium stearate		Methylparaben	Propylene glycol
Talc		Propylparaben	Sodium benzoate
Colloidal silicon anhydrate	Pineapple flavor	Pineapple flavor	Diethylene glycol monoethyl ether
Sodium glycogen glycollate	Sodium carboxymethyl starch	Quinoline yellow dye	Polyoxyl 40 from castor oil
Calcium hydrogen phosphate	Calcium phosphate	Xanthan gum	Carbomer 940
	Silicon dioxide	Polysorbate 80	Disodium edetate
	Aspartame	Citric acid	Water
		Glycerol	Butylated hydroxytoluene
		Water	Capsaicin
			Menthol
			Trometamol

Therapeutic effect

Nise is a drug from the group of non-steroidal anti-inflammatory drugs(NSAIDs) and has three main therapeutic effects:

• Analgesic effect (analgesic);
• Antipyretic effect (reduces body temperature);
• Anti-inflammatory effect.

All three therapeutic effects are due to the ability of the active substance Nise to block the work cyclooxygenase – an enzyme that synthesizes prostaglandins and leukotrienes. Prostaglandins and leukotrienes are substances that activate and maintain the inflammatory process, causing tissue damage, swelling, pain and redness. In turn, inflammation provokes cell death and the formation of large amounts of toxic substances that enter the systemic bloodstream and provoke an increase in body temperature.

Nise, by blocking the work of cyclooxygenase, prevents the formation of leukotrienes and prostaglandins, which, in turn, stops the active course of the inflammatory process. Since the inflammatory process is minimized, the associated pain, heat, swelling and redness are relieved. The functioning of the affected organ is also facilitated.

Since Nise has a nonspecific effect, it is able to provide a therapeutic effect in the inflammatory process, regardless of the location and nature of the cause that caused it. That is why Nise is able to relieve pain during menstruation, joint diseases, injuries, neuralgia, headaches, toothaches, etc. The drug also perfectly reduces body temperature during a viral or bacterial infection, and also reduces the severity of any inflammatory process, regardless of what exactly it is caused by (for example, infection, autoimmune disease, injury, etc.).

In terms of the severity of the anti-inflammatory effect, Nise is superior to Indomethacin, Diclofenac, Ibuprofen and Piroxicam. The analgesic effect of Nise is the same as that of Ibuprofen, but less pronounced compared to Indomethacin. Antipyretic Nise action and more powerful than that of Indomethacin, Ibuprofen, Aspirin and Paracetamol.

Since Nise can exert its effects locally and systemically, it is used in various dosage forms depending on the location of the inflammatory process and pain. For example, when pain and inflammation are localized in internal organs and mucous membranes, it is necessary to take Nise orally so that the drug can reach all affected cells and tissues through the bloodstream. And if the pain is localized in the muscles or skin, you can not take Nise orally, but apply it externally, directly to the affected area, so that the active substances penetrate to the source of inflammation through the skin structures. Often, to enhance the therapeutic effect, the drug is simultaneously taken orally and applied externally, especially for chronic joint diseases.

In addition to the antipyretic, anti-inflammatory and analgesic effects, Nise has a number of other, less significant and less pronounced effects. Thus, the drug reduces the ability of platelets to stick together (aggregate) and form blood clots by suppressing platelet activity factor.

Nise - indications for use

Let's consider the indications for the use of forms for oral and external use in children and adults.

Tablets, dispersible tablets and Nise suspension

All dosage forms of Nise for oral administration are indicated for use in adults with the following diseases or conditions:

• Rheumatoid arthritis;
• Joint damage due to rheumatism;
• Periods of exacerbation of gout;
• Psoriatic arthritis;
• Ankylosing spondylitis;
• Osteochondrosis;
• Radiculitis;
• Sciatica;
• Lumbago;
• Osteoarthritis;
• Arthritis of any cause;
• Joint pain (arthralgia);
• Muscle pain (myalgia);
• Inflammation of ligaments and tendons (tendonitis, tendovaginitis, etc.);
• Bursitis;
• Traumatic inflammation of the soft tissues of the musculoskeletal system (for example, after bruises, ruptures and sprains, etc.);
• Pain of various origins and localization (menstrual, dental, joint, headache, pain after surgery, with gynecological and ENT diseases, etc.);
• Increased body temperature of any origin.

Nise suspension is indicated for use in children with the following diseases or conditions:

• Increased body temperature due to any disease, including after vaccination;
• Inflammatory process of the ENT organs and respiratory tract during viral or bacterial infections;
• Relief of pain after operations, injuries, soft tissue injuries, etc.

It should be remembered that in children and adults Nise is a symptomatic remedy that does not cure the disease, but can only relieve pain, relieve fever and reduce inflammation, thereby easing and improving the general condition of a person. Therefore, it should always be used in combination with other medications, the effects of which are aimed at curing pathology or achieving remission.

Nise gel (ointment)

The gel is used externally in adults and children over 7 years of age with the following diseases or conditions:

• Inflammatory or degenerative diseases of bones, joints, ligaments, muscles and tendons, such as gout, rheumatism, arthritis, osteoarthritis, osteochondrosis, radiculitis, lumbago, bursitis, tendinitis, sciatica, etc.;
• Muscle pain of any origin;
• Traumatic inflammation of the musculoskeletal system (for example, bruises, tears or sprains of muscles, ligaments, etc.).

The gel, like the oral forms, is intended exclusively for symptomatic therapy, that is, relieving pain, fever and reducing inflammation. The gel will not cure a torn ligament, but will only relieve the symptoms of this condition. Therefore, in combination with Nise gel, it is necessary to use drugs or manipulations whose action is aimed at curing the disease.

Instructions for use

Let's consider the rules for using different dosage forms of Nise separately to avoid confusion.

Nise tablets - instructions for use

The tablets should be taken immediately after meals. The tablet is swallowed whole, without biting, chewing or crushing in any other way, but with a small amount of water (100 - 200 ml). It is not recommended to take Nise tablets before meals, as this may cause irritation or discomfort in the stomach.

Nise tablets can be given to children from 12 years of age.

Nise is given to children over 12 years of age in the same dosages as adults. Elderly people over the age of 65 should also take Nise in standard, unreduced dosages. In case of renal failure with creatinine clearance determined by the Rehberg test of at least 30 ml/min, there is also no need to reduce the dosage of the drug. If creatinine clearance is below 30 ml/min, then Nise cannot be used in any dosage.

To relieve pain, relieve fever or reduce the severity of inflammation, it is recommended to take Nise 1 tablet (100 mg) twice a day. It is advisable to take the tablets at regular intervals, for example every 12 hours. If necessary, you can increase the number of tablets to 4 tablets per day, which can be taken at intervals of at least 6 hours. The maximum permissible daily dosage of Nise is 400 mg, exceeding which can provoke an overdose.

The duration of taking Nise is determined by the speed of healing and reduction in the severity of painful symptoms. That is, in each specific case, the duration of the course of therapy is determined individually and can range from several days to several weeks.

Instructions for use of Nise dispersible tablets

Dispersible tablets must be taken either with or immediately after a meal. It is not recommended to take the drug in this form before meals, since there is a high risk of developing side effects from the digestive tract.

Before taking, one tablet is dissolved in a teaspoon of water. If you need to take two tablets at once, it is optimal to dissolve them both in a tablespoon of water. In general, to calculate the required amount of water, you can use the following ratio - one tablet per 5 ml of water (1 teaspoon).

Dissolved tablets are taken without additional water or any other drinks. If a person has a desire to wash away the feeling and taste of tablets from the oral mucosa, then they can take a large sip of clean water.

Dispersible tablets can be given to children from three years of age.

To relieve pain, fever and inflammation in various diseases, adults and adolescents over 12 years of age should take Nise 100 mg (2 dispersible tablets) twice a day. If necessary, you can increase the frequency of taking tablets up to 4 times a day, keeping at least 6-hour intervals between them. The maximum permissible daily dosage of Nise for adults and children over 12 years of age is 400 mg.

In elderly people over 65 years of age and with renal failure with a creatinine clearance of at least 30 ml/min, Nise is used in normal dosages, which do not need to be reduced. In case of renal failure with creatinine clearance below 30 ml/min, Nise cannot be used in principle.

For children aged 3 – 12 years, the daily dosage of Nise is calculated individually according to body weight, based on the ratio of 3 – 5 mg per 1 kg of weight. For example, a child weighing 20 kg should take Nise at a dosage of 3 * 20 = 60 mg and 5 * 20 = 120 mg, that is, 60 – 120 mg per day. The daily dosage calculated in this way is divided into 2 - 3 equal parts for administration 2 - 3 times a day at approximately equal intervals. The maximum permissible daily dosage of Nise is 5 mg per 1 kg of child’s body weight. If the child weighs more than 40 kg, but is under 12 years old, then he is given Nise in an adult dosage of 100 mg twice a day.

The duration of use of Nise is determined individually depending on the speed of disappearance of symptoms.

Instructions for use of Nise suspension

It is recommended to take the suspension before meals, however, if any unpleasant sensations occur in the stomach, you must switch to taking the drug immediately after finishing the meal.

Before use, shake the bottle with the suspension so that its contents become homogeneous, then pour the required amount into a measuring cup or syringe and drink. If necessary, you can wash down the suspension with a small amount of water.
Nise in the form of a suspension can be used for children from two months in the following dosages:

• Children aged 2 months - 2 years - the dosage of the suspension is calculated individually according to body weight, based on the ratio of 1.5 mg per 1 kg of weight. That is, a child weighing 10 kg needs 1.5 * 10 = 15 mg of Nise per day. The calculated daily amount of the drug is divided into 2 - 3 equal parts and given to the child 2 - 3 times a day. In our example, 15 mg/3 = 5 mg, that is, the child needs to be given a Nise suspension of 5 mg (which corresponds to 0.5 ml or 13 drops) three times a day;
• Children aged 2 – 5 years – take 2.5 ml of suspension 2 – 3 times a day;
• Children 5 – 12 years old – take 5 ml of suspension 2 – 3 times a day;
• Children over 12 years old - take the drug in an adult dosage in any dosage form, that is, 100 mg 2 times a day, which corresponds to 10 ml of suspension, 1 regular tablet or 2 dispersible tablets.

The suspension can be used not only for children, but also for adults who, for some reason, cannot or do not want to take tablets. In all cases, for a person of any age there are no restrictions on the use of the Nise suspension; it is only necessary to dose the drug correctly. The only category of people who are undesirable to take Nise in the form of a suspension due to the presence of sucrose in it are patients with diabetes mellitus.

The duration of taking Nise suspension is different and depends on the speed of normalization of the person’s condition and the disappearance of symptoms. For acute conditions, it is recommended to use Nise for no more than 5–10 days.

Gel (ointment) Nise - instructions for use

The gel is applied to previously washed and dried areas of the skin in the area of ​​direct projection of pain and inflammation. If the wound is not open, then wash the skin with warm water and soap and dry it well with a soft towel. If there is an open wound on the skin, symptoms of dermatitis or any damage, then Nise gel should not be applied.

For a one-time application, squeeze out approximately 3 cm of gel from the tube and, without rubbing, distribute it evenly over the affected surface. Then leave for 1 - 2 minutes so that the composition is absorbed into the skin. After this, you can apply a regular gauze bandage to the damaged area or leave it uncovered. Airtight dressings should not be applied over the gel.

The gel is applied to the skin 3 – 4 times a day. It is not recommended to apply the gel more than 4 times a day, as this may cause the development of side effects. The maximum allowable amount of gel that can be used per day is 30 g, which corresponds to 1.5 tubes of 20 g.

The duration of use of the gel is determined individually depending on the speed of disappearance of unpleasant symptoms. It is not recommended to use Nise gel for more than 10 days in a row without consulting a doctor.

When rubbing the gel into the surface of the skin, a burn may occur, which will go away on its own within a few days. If irritation appears in the area where the gel is applied, you should stop using Nise.

Capsaicin, which is part of the gel, can provoke a burning sensation and redness of the skin in the area of ​​application. In rare cases, the burning sensation does not disappear, but turns into increased sensitivity of this area of ​​the skin. These effects are a normal skin reaction to the gel and do not require discontinuation of the drug.

When using the gel, it is necessary to avoid contact with the eyes, as well as the mucous membranes of the nose, mouth and other organs. After using the drug, close the tube tightly and wash your hands with soap.

Special instructions

Nise in the form of tablets, dispersible tablets and suspensions should be used with caution in people suffering from eye, kidney and liver diseases. If creatinine clearance against the background of renal failure is less than 30 ml/min, then Nise cannot be used. In other cases, with renal failure, the drug is allowed for use, but with caution and under the close supervision of a doctor. During the entire period of therapy, if it lasts more than a week, the functioning of the liver and kidneys should be monitored. If there is a deterioration in the condition or function of the kidneys or liver, then Nise should be discontinued and any drugs containing nimesulide should not be used in the future.

Nise should also be used with caution by people suffering from cardiovascular diseases, dehydration, asthenia, metabolic disorders and diseases of the digestive tract.

Since Nise is able to reduce blood clotting, it should be used with caution by people prone to bleeding, taking anticoagulants and suffering from hemorrhagic diathesis. If these conditions are present, blood clotting parameters (platelet count, fibrinogen, APTT, PTI, INR, TV, etc.) should be monitored during the entire course of using Nise.

In order to reduce the risk of side effects, it is necessary to use Nise in the minimum effective dosage. If a person’s condition does not improve within 2–3 days while using Nise, then you should stop taking the drug and consult a doctor.

If, while taking Nise tablets or suspension, a person experiences nausea, anorexia, vomiting, abdominal pain, dark urine, yellowing of the skin, increased activity of AST and ALT, as well as fatigue, then you should immediately stop using the drug and consult a doctor, since these symptoms indicate the development of liver damage. In the future, a person who experiences similar symptoms should not take Nise or any other medications containing nimesulide.

Impact on the ability to operate machinery

Gel Nise does not impair the ability to operate machinery. Nise tablets and suspension can cause dizziness and drowsiness, therefore, while taking these dosage forms of the drug, you should refrain from any activities that require a high reaction rate and concentration.

Overdose

The gel, as a rule, does not cause an overdose. However, when applying more than 50 g of gel at a time, this is possible. When using tablets and suspensions, an overdose is also possible, and it is manifested by the following symptoms:

• Apathy;
• Drowsiness;
• Nausea;
• Increased pressure;
• Impaired kidney function (swelling, urinary retention, increased concentration of urea, creatinine in the blood, etc.);
• Irritation of the digestive tract;
• Gastrointestinal bleeding;
• Respiratory depression;

Treatment of overdose consists of gastric lavage, taking sorbents (activated carbon, Polysorb, Polyphepan, Enterosgel, etc.) and laxatives, followed by maintaining the normal functioning of organs and systems.

Interaction with other drugs

Nise reduces the effect of Furosemide and enhances the effects of anticoagulants, Cyclosporine and lithium compounds. The risk of side effects increases when Nise is used simultaneously with Methotrexate, glucocorticosteroids and serotonin reuptake inhibitors.

Nise for children

Nise is approved for use in children only as prescribed by a doctor because, although in rare cases, it can cause severe side effects. Depending on the age of the child, it is recommended to use different forms of the drug:

• Children under 3 years old - only Nise suspension can be given;
• Children 3 – 12 years old – you can give dispersible tablets or Nise suspension;
• Children over 12 years old - Nise can be given in any form.

Dosages of the drug for children are also determined by age:

• Children aged 2 months - 2 years - the dosage of the suspension is calculated individually according to body weight, based on the ratio of 1.5 mg per 1 kg of weight. The calculated daily amount of the drug is divided into 2 - 3 equal parts and given to the child 2 - 3 times a day;
• Children aged 2 – 5 years – take 2.5 ml of suspension 2 – 3 times a day. The dosage of dispersible tablets is calculated individually according to the ratio of 3 – 5 mg per 1 kg of weight;
• Children 5 – 12 years old – take 5 ml of suspension or 1 dispersible tablet 2 – 3 times a day;
• Children over 12 years of age - take the drug in an adult dosage in any dosage form, that is, 100 mg (10 ml suspension, 1 regular tablet or 2 dispersible tablets) 2 times a day.

Use during pregnancy and breastfeeding

Nise can have a negative effect on fertility, pregnancy and fetal development, so the drug is not recommended for use during the entire period of gestation, as well as at the stage of pregnancy planning. The use of Nise is also contraindicated during breastfeeding, since it is unknown whether the drug is excreted in milk.

Nise for pain, including dental

For pain of various localizations, Nise should be taken in the form of tablets or suspension a maximum of every 6 hours, that is, 4 times a day. Adults and children over 12 years of age are recommended to take 100 mg at a time, children 5–12 years old – 50 mg, and children 2–5 years old – 25 mg. Nise relieves pain well, but if the effect of the drug is not enough, then you should not take it often and a lot (for example, 2 - 3 tablets every 1 - 2 hours), but replace it with another that has a stronger analgesic effect, for example, Ketorol or Ketonal.

Nise by temperature

Nise perfectly lowers the temperature, keeping it within normal limits for a fairly long period of time. However, since the drug can cause severe side effects, Nise should not be used, especially in children, as a first-line drug to reduce body temperature. It is recommended to use Nise as a last-line remedy when Paracetamol and Ibuprofen are ineffective and the body temperature does not return to normal after taking them.

Alcohol compatibility

Since both alcohol and Nise have a toxic effect on the liver, their combined use is not advisable. When drinking alcoholic beverages while taking Nise, the risk of liver damage and the development of toxic hepatitis significantly increases.

Side effects of Nise

Regular and dispersible tablets, as well as Nise suspension, can provoke the following side effects from various organs and systems:
1. Allergic reactions:

• Skin rash;
• Bronchospasm;

2. Central nervous system:

• Dizziness;
• Feeling of fear;
• Nightmares;
• Drowsiness;
• Reye's syndrome.

3. Leather:

• Rash;
• Dermatitis;
• Hives;
• Swelling;
• Exudative erythema multiforme;
• Lyell's syndrome;
• Stevens-Johnson syndrome.

4. Urinary system:

• Edema;
• Urinary retention;
• Increased potassium concentration in the blood;
• Kidney failure;
• Decreased amount of urine;
• Interstitial nephritis.

5. Digestive tract:

• Nausea;
• Vomit;
• Abdominal pain;
• Tarry stools;
• Bleeding from the gastrointestinal tract;
• Stomach or intestinal ulcer.

6. Liver and bile ducts:

• Increased activity of AST and ALT;
• Hepatitis;

Belonging to the class of sulfonanilides. According to the classification, the drug belongs to the group of non-narcotic painkillers and anti-inflammatory drugs. the gel has a pronounced analgesic effect and is used for various types of arthritis and other lesions of the musculoskeletal system to eliminate pain.

Dosage form

The product is produced in the form of a gel intended for external use, sold in tubes of 20 and 50 grams.

Description and composition

The drug is produced in tubes of 20 and 50 grams. The product has a white or pale yellow color and a uniform consistency - the presence of foreign particles is unacceptable.

The drug contains the following substances:

• methyl salicylate;
• matanol;
• capsaicin.

The list of auxiliary components includes:

• distilled water;
• sodium benzoate;
• disodium salt of ethylenediaminetetraacetic acid;
• trometamol;
• hydroxytoluene;
• polyoxylcastor oil;
• monoethyl diethylene glycol ether;
• propylene glycol;
• diethyl phthalate;
• non-toxic gelling agent carbomer.

Pharmacological group

The gel belongs to the group of non-steroidal anti-inflammatory drugs of the latest generation. The main active component is, which has a local analgesic effect. The composition has a local antipyretic effect, removing heat from the affected areas.

Methanol has analgesic and antipruritic effects. The effectiveness is due to the composition’s ability to irritate nerve endings, skin receptors and mucous membranes. Provides the production and release of substances involved in the processes of pain regulation.

Methyl acylate ensures increased blood circulation in the affected areas. The component eliminates swelling and relieves inflammation. The product reduces the intensity of painful sensations. Often, during use, allergic reactions occur that do not require stopping the use of the product.

Indications for use

The list of indications for use of the product is as follows:

• bursitis;
• synovitis;
• lumbodynia;
• arthritis;
• osteoarthritis;
• osteoarthrosis;
• tendenitis;
• nerve damage, various neuralgia;
• myalgia;
• lesions of the internal membranes of the vagina in women;
• Bekhterev's disease;
• rheumatism;
• damage to joints and tissues manifested against the background of metabolic processes;
• radiculitis;
• pain manifested in the spinal column.

for adults

The gel product can be used in patients belonging to these groups who do not have contraindications to the use of the composition.

for children

The use of the composition in pediatrics is prohibited. If there are acute indications, the composition can be used for children over 7 years of age. The patient's well-being in this case should be constantly monitored. The occurrence of adverse reactions is a good reason for refusing to use the product.

Gel for external use is not recommended for use during pregnancy; the active component of the composition has the ability to be absorbed into the systemic bloodstream. Using the product can cause various developmental defects in a child. Use of the product during pregnancy is not recommended.

Contraindications

All medications have a certain list of contraindications for use, and the gel is no exception. The list of contraindications includes:

• hypersensitivity to the active or auxiliary components of the composition;
• ulcerative or erosive lesions of the gastrointestinal tract;
• stomach bleeding;
• lesions of the epidermis at the site of application;
• infectious skin lesions;
• violation of the integrity of the skin at the site of use of the product;
• acute renal failure or its chronic course;
• pathologies of the hematopoietic organs;
• pregnancy period;
• childhood.

Increased caution is required when using the product in patients with the following lesions:

• hypertension;
• heart rhythm disturbances;
• insulin-dependent diabetes;
• old age.

The use of the product in the presence of contraindications is unacceptable. In this case, the actions will cause significant harm.

Applications and dosages

Before using the product, rinse the treated area thoroughly with clean water. The area where the product is applied must be free of damage. A single dosage per day should not exceed 3 cm. Apply the product only to the area with severe pain. The drug should be absorbed on its own; you should not rub it into the skin. There is also no need to use bandages; it is important to provide air access.

for adults

The product is applied to previously prepared areas of the skin. The daily dose of use is 3-4 times a day. The maximum duration of therapy is 1-2 weeks.

for children

for pregnant women and during lactation

Use of the product during pregnancy and breastfeeding is strictly prohibited. If there is an urgent need to use the composition during lactation, the issue of transferring the child to formula milk is decided.

Side effects

Adverse reactions with the use of the gel are extremely rare. If the patient has hypersensitivity to the components of the product, an allergy may develop:

• peeling of the skin;
• itching of the skin;
• change in skin color;
• burning sensation.

Reactions of this nature do not require discontinuation of the drug and disappear on their own.

Adverse reactions from the following list occur extremely rarely, in particular with prolonged and improper use:

• a feeling of tightness behind the sternum;
• burning sensation in the larynx;
• digestive disorders;
• headache and migraine;
• dizziness;
• nausea and;
• delayed diuresis;
• anemia.

If these symptoms occur, you should seek emergency medical help. In some cases, emergency refusal to use the product and its subsequent replacement is indicated. In rare cases, with prolonged use of the gel, renal failure develops, the symptom of which is disruption of the processes of removing fluid from the body.

Interaction with other drugs

It has the ability to enhance the effect of agents that inhibit the blood clotting process. Reduces the effectiveness of antihypertensive compounds and diuretics. It is not recommended to use in combination with. may increase the concentration of lithium in the patient's blood. Enhances the activity of cyclosporine.

Special instructions

The list of special instructions is as follows:

1. The drug can be applied to intact skin.
2. Avoid contact of the composition with mucous membranes.
3. The drug is used exclusively externally. After use, you should wash your hands; you can use disposable gloves for application.

The composition does not affect psychomotor reactions and the ability to concentrate.

Overdose

Cases of overdose have not been recorded in official medical practice. The risk of developing undesirable effects increases due to non-compliance with recommended doses and rules of use. An overdose is manifested by a general deterioration in health: nausea, clouding of consciousness. An elevated temperature often occurs. A specific antidote has not been found; if you suspect an overdose, you should contact a specialist as an emergency. If consumed orally, gastric lavage is performed, emergency hospitalization is indicated, and hemodialysis can be used.

Storage conditions

The drug is sold to the public through a network of pharmacies for free sale; a prescription from a doctor is not required. The product should be stored in its original packaging for two years from the date of issue. The room temperature should not exceed 25 degrees. Children's access to the place where medicines are stored should be limited.

Painful sensations, regardless of their origin, cause a lot of inconvenience to a person. The situation is aggravated if the problem is localized in the area of ​​soft tissues and joints. In such cases, the body becomes stiff, and every movement causes pain.

What to do, who to turn to for help, and is it possible to get rid of these symptoms at all? It turns out that the simplest and most effective way to solve the problem is right in front of your eyes - instructions for using Nise Gel.

Nise gel is a local non-steroidal medicine that helps cope with pain and fever in diseases of various etiologies. It is actively used in the treatment of bursitis, osteoarthritis, tendovaginitis, osteoarthritis, as well as a number of other inflammatory ailments. The drug has become widespread among both doctors and patients.

Nice gel features:

1. Clinical studies have confirmed that the medication is absolutely safe.
2. A nominal amount of active substances penetrates through the surface of the skin into the main bloodstream.
3. The maximum concentration in the body is formed only 24 hours after using the gel.
4. The drug composition does not affect the chemical composition of blood plasma.

The medication does not accumulate in tissues, joints or internal organs, but is completely eliminated through the liver.

Pharmacological group and action

Nise ointment belongs to a large pharmacological group of topical nonsteroidal anti-inflammatory drugs (sulfonanilide class) (NSAIDs). After application to a problem area of ​​the body, it eliminates inflammatory processes in joints and soft tissues, and relieves painful symptoms. The main active ingredient of the drug is nimesulide, which causes a therapeutic, analgesic effect.

Mechanism of action of the drug:

• Prevents the synthesis of prostaglandin at the site of the inflammatory process (without this element the formation of edema and painful sensations is impossible).
• Inhibits COX, acting selectively on problem areas. In rare cases, it affects healthy cells.
• Menthol in the composition of the medication helps to activate cold receptors, resulting in a calming effect.
• Joint and bone tissue are nourished in the form of calcium ions, thanks to which the affected area is quickly saturated with nutrients and oxygen.

Methyl salicylate increases the intensity of blood flow at the site of application (after hydrolysis), suppresses biochemical processes associated with the formation of edema and severe pain (including lipid oxidation). Due to which there is a local anti-inflammatory and analgesic effect, the amplitude and range of movements gradually increases

Release form and composition

The pharmaceutical drug is available in the form of a white translucent gel (for some manufacturers the color is shifted towards yellow tones). It is a homogeneous, medium-thick consistency without any foreign inclusions or substances. Available for sale in aluminum tubes of 20 and 50 g. Supplied in a separate cardboard box with annotation.

The composition of the Nice gel includes 4 active substances (per 1 g of product):

A number of excipients are also present: thimerosal, macrogol, isopropanol, carbomer 940, propylene glycol.

Storage conditions and shelf life of the drug

The gel is prescribed to be stored in a dark place at a temperature of 24 °C; it is important to avoid contact of the aluminum tube with direct sunlight and sources of moisture. When placed in the refrigerator and frozen, the drug loses its declared properties.

The shelf life in a sealed tube, subject to the above requirements, is 24 months from the date of manufacture indicated on the cardboard box. If the tube is damaged, the thickness of the consistency, color changes, or a pronounced odor appears, use of the medicine is strictly prohibited!

Instructions for use

It is necessary to use a pharmaceutical drug for the treatment of joint pain as prescribed by a doctor. When using the composition yourself, it is important to read in detail the instructions for applying the Nise gel. To achieve the desired effect, it is recommended to strictly adhere to the indicated dosage and frequency of procedures.

There is only one method of use for the drug - external, local.

Step by step instructions:

1. The area where the gel is applied is washed with soap and water, if possible treated with an antiseptic, and wiped dry with a towel.
2. The medicinal composition is applied only to “clean” skin, without inflammation, damage or ulcers.
3. The recommended amount of gel for application to the surface of the skin is up to 3 cm (3 g) for 1 procedure.
4. The consistency of medium thickness is evenly distributed over the problem area, forming a thin layer of coating. Healthy skin is not treated!
5. It is forbidden to rub the drug into the epithelium; the absorption process occurs naturally without outside intervention.
6. An anti-inflammatory, antipyretic agent is applied 1-3 times a day (every 8-12 hours), every day (no more than 10 days).

After applying the medication to the surface of the skin, it may cause itching and burning. It stops without patient intervention after 2-4 minutes. The duration of treatment is determined by the doctor, based on the characteristics of the pathology and accompanying symptoms.

Indications for use

A feature of the Nise gel is its wide spectrum of action. It is used to combat ailments of the musculoskeletal system, relieving painful sensations that develop against the background of elevated body temperature.

Main indications for use:

Nise ointment is often prescribed for bruises, injuries, bruises, inflammations localized in cartilage and bone tissue.

Contraindications and side effects

There is not a single pharmaceutical drug that does not have contraindications. Nise gel also has restrictions on its use.

It is prohibited to apply the composition when:

• open wounds, active inflammatory processes accompanied by purulent discharge;
• severe renal failure;
• high sensitivity to active or auxiliary substances;
• internal bleeding localized in the stomach area;
• extensive lesions of the digestive tract with ulcers;
• problems with blood formation;
• children under 7 years of age.

Elderly patients diagnosed with hypertension, diabetes mellitus (type 2), and pathologies of the cardiovascular system should exercise extreme caution when applying the medicine.

Overdose is often accompanied by side effects (despite the lack of officially confirmed data):

• migraine attacks;
• erosive formations on the gastric mucosa;
• nausea followed by vomiting;
• burning;
• problems with blood formation;
• severe allergic reactions;
• local swelling;
• dizziness.

If after taking the medication the patient experiences an unpleasant sensation or one of the side effects, the subsequent use of the medication should be discontinued. It is equally important to seek medical help promptly.

Use during pregnancy and lactation

Pregnant women are strictly prohibited from applying Nise Gel. To prevent joint pain, substitutes or analogues are used as prescribed by a doctor. Similar restrictions are imposed during lactation. If there is an urgent need to use the particular composition in question, breastfeeding is stopped until the end of the therapeutic course.

Interaction with other drugs

Nise gel is used with extreme caution if the patient is already prescribed the following drugs: lithium-containing drugs, NSAIDs, digoxin, phenytoin, cyclosporine, hypoglycemic and antihypertensive drugs. It is imperative to notify the attending physician (if there are several, consult with each).

Directions for use and doses

Nise cream, in accordance with the instructions, is used exclusively externally. The safe dose when applying the composition is a strip 2.5-3 cm long. For children - 1.5-2 cm. Use the composition 3 to 4 times a day (children - 1 to 3 times). Treatment is limited in time to 10 days. If there is no positive dynamics within 7 days, it is recommended to consult a doctor for adjustment of the therapeutic course.

Special instructions

Nise ointment is applied only to clean and intact skin. It is important to avoid contact of the drug with open wounds and mucous membranes. It is strictly forbidden to take the medication orally.

A few important instructions:

1. The gel is not intended for children under 7 years of age.
2. Applying sealed and tight bandages with the medication in question is taboo.
3. After applying the thick consistency to the problem area, screw the tube cap tightly.
4. Before and after the procedure, hands are thoroughly washed with antibacterial soap.

It is safest to fight the disease under the supervision of a specialist. A personal treatment and therapy regimen must be prepared for each patient.