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Nise gel indications for use. "Nise Gel" - instructions, composition, method of application

Nise gel is a drug for local use that belongs to the anti-inflammatory group of non-steroidal drugs. The medication is successfully used in the treatment of diseases associated with inflammatory nature, bursitis, tendovaginitis, osteoarthritis, and osteoarthritis. The medicine can be purchased in the form of a gel, ointment or cream. It has anti-inflammatory, antipyretic and analgesic effects.

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Release form and composition

The drug is produced in tubes of 20 g and 50 g. It is in cardboard packages. The medicine is free from foreign particles and has a yellow, transparent or light yellow color.

1 g of the medicine contains 10 mg of the active ingredient nimesulide.

IN Nise composition gel, cream and ointment include the following excipients:

thimerosal;
propylene glycol;
flavorings;
pyrrolidone;
isopropanol;
potassium phosphate;
macrogol;
940 carbomer.

Pharmacology

This anti-inflammatory drug is of non-steroidal origin and belongs to the sulfonanilide type. Nimesulide is the active element of the drug, which has antipyretic, analgesic and anti-inflammatory effects. This action is due to the selective shutdown of 2-cyclooxygenase.

Methanol has antipruritic, antiseptic, analgesic, sedative and local thinning effects. The effect of the drug is associated with reflexes that appear due to irritating effects on the mucous membranes and nerve endings of the receptors. The medical product releases and produces elements that are actively involved in vascular permeability and regulation painful sensations. They provide antipruritic and distracting effects.

External and local use of the product is accompanied by a feeling of coldness and vasoconstriction. It turns into a tingling and burning effect. These processes improve vascular tone and tissue trophism.

Methyl salicylate is hydrolyzed, actively penetrates, is absorbed and converted into an anion salicylic acid. The substance reduces the production of prostaglandins and lowers cyclooxygenase. These elements are responsible for increased body temperature, soreness, inflammation and swelling. Methyl salicylate reduces pain in tissues, muscles and joints, normalizes capillary permeability.

Indications

Indications for use of Nise gel, ointment or cream - relief of inflammation and pain. Medical drug used in the following cases:

radiculitis;
tendon inflammation, sciatic nerve, ligaments;
chondrosis;
osteoarthritis;
rheumatism and gout;
ankylosing spondylitis;
joint disease due to psoriasis and rheumatoid nature;
pain in ligaments and muscles due to injury.

Directions for use

Gel, cream and Nise ointment prescribed only externally. It is necessary to follow the dosage prescribed by the attending physician and indicated in the instructions for use. Before starting the procedure, you need to prepare the affected area. It must be dry and clean. It is necessary to squeeze out the product no more than 2 cm long. The medicine is applied to the sore spot with gentle movements and a thin layer.

The medication is allowed to be used no more than four times a day. The duration of therapy is 14 days. If after 10 days there is no positive effect from therapy, you should consult your doctor.

The drug is not recommended for use if there is damage to the skin. A few minutes after applying the ointment, gel or cream, a burning sensation may be observed. Do not allow the medicine to come into contact with mucous membranes or eyes.

For joint diseases, it must be used during a period of complete or unstable remission.

Side effects and overdose

When using Nise ointment, cream or gel, adverse reactions may occur. Quite rarely, hives, burning sensations, changes in skin color, itching, swelling or peeling occur. With such symptoms, the drug is not canceled, as they go away on their own after a few days.

If you use medical product over time, the following reactions may occur:

anemia;
fluid retention;
burning behind the sternum and in the larynx;
nausea and vomiting;
digestive disorders;
the occurrence of erosions and small ulcers on the mucous membrane;
thrombocytopenia;
headache, migraine and feeling of dizziness;
change in blood test;
the occurrence of allergies, in in rare cases anaphylactic shock;
development of liver transaminase activity.

IN similar cases it is necessary to discontinue the drug and consult your doctor for advice and change the treatment regimen.

No cases of drug overdose with Nise have been identified. Negative side effects may appear due to an exceeded dosage of 50. There is no official antidote, so if side effects develop, it is necessary to call " ambulance" and begin symptomatic treatment.

Contraindications

Contraindications include the following conditions:

hypersensitivity to one of the components of the gel;
acute damage to the digestive system by ulcers or erosions;
stomach/intestinal bleeding;
dermatoses of various etiologies, damage to the upper layers of the epidermis;
infectious skin diseases;
acute renal failure;
pathological processes in the hematopoietic system;
history of bronchospasms caused by the use of other anti-inflammatory drugs.

Medicine It is prohibited to use by pregnant women. If they have joint pain, they should consult their doctor for advice. He will appoint similar means. Breastfeeding must be stopped during treatment.

Efficiency

Easy to find in pharmacies

Side effects

Average rating

Based on 3 reviews

Joint pain with various pathologies are so intense that they not only worsen the patient’s general well-being, but also significantly reduce his quality of life. Today, pharmacological companies have developed a large number of medicines that help in the fight against painful symptoms joint diseases. One of these drugs is Nise Gel, which is popular not only among patients, but also among specialists.

Pharmacological action of the drug

Nise is a non-steroidal anti-inflammatory drug latest generation, belonging to the class of sulfonanilides. Included in it nimesulide has a local analgesic, anti-inflammatory and antipyretic effect. A similar effect is caused by the selective “switching off” of cyclooxygenase-2 and some other mechanisms.

Methanol, which is also present in the drug, acts as a local thinning, analgesic, antipruritic substance. Methanol is also an antiseptic and local sedative. The effect of methanol on the application site is due to reflexes that are associated with irritation of the nerve endings of the skin receptors and mucous membranes. Stimulates the production and release of substances that are involved in the regulation of pain, vascular permeability and other processes, providing a distracting, antipruritic effect. Local external use of the substance is accompanied by vascular constriction, a feeling of coldness, which smoothly turns into a feeling of slight burning and tingling. Tissue trophism improves reflexively, tone changes blood vessels, located both on the surface and deep in tissues and organs.

Nise also contains methyl salicylate, which, when applied topically, quickly penetrates deep into the skin, is absorbed and hydrolyzed, and then turns into an anion of salicylic acid. The substance actively inhibits cyclooxygenase, reduces the synthesis of prostaglandins, which are responsible for inflammatory process, pain, swelling and fever. Normalizes capillary permeability, which is much increased during inflammation, improves microcirculation, reduces swelling and inflammation, reduces intensity pain at different pathological processes in joints, muscles and tissues.

Release form

Transparent pale yellow gel or white free of foreign particles. The drug is produced in 20 and 50 gram aluminum tubes. Each individual tube is placed in an individual cardboard box along with instructions for use of the drug.

Ask your question to a neurologist for free

Irina Martynova. Graduated from Voronezh State University medical university them. N.N. Burdenko. Clinical resident and neurologist of the BUZ VO \"Moscow Polyclinic\".

Compound

nimesulide - 10 mg;
methyl salicylate - 100 mg;
methanol - 50 mg;
capsaicin - 0.250 mg.

diethyl phthalate - 50 mg;
monoethyl diethylene glycol ether - 50 mg;
polyoxylcastor oil - 50 mg;
propylene glycol - 70 mg;
sodium benzoate - 1 mg;
disodium salt of ethylenediaminetetraacetic acid - 1 mg;
Butylated hydroxytoluene - 0.4 mg;
non-toxic gelling agent carbomer-980 - 12 mg;
trometamol - 2 mg;
distilled water.

Instructions

Indications

- inflammation bursa- bursitis;
- inflammation of the synovial joint membrane - synovitis;
- chronic pain in the lumbar region - ;
- joint inflammation -
- deforming diseases of non-inflammatory joints - osteoarthritis and osteoarthritis;
- inflammation of the tendons - tendonitis;
- pain along the nerve - ;
- muscle pain associated with hypertonicity - myalgia;
- inflammation inner shell tendon sheath - tenosynovitis;

Bekhterev's disease;
rheumatism;
pathology of tissues and joints caused by metabolic disorders - ;
pathology of the spinal nerve roots - ;
pain symptoms V spinal column, muscles and joints of unknown etiology.

Directions for use

The drug is suitable for external use only! The use of Nise Gel internally is strictly prohibited

Use for the treatment of joint pain must be strictly in accordance with official instructions for use. It is very important to follow the recommended dosage and frequency of use.

The basic rules of application are:

The area of skin to which the medicine is applied must be cleaned with water and soap and dried thoroughly with a towel.
The application site must be intact, open ulcers and various skin inflammations must be absent.
The multiple dosage of the drug should be no more than 3 cm of squeezed gel from the tube.
Apply the product only to the area where pain is felt.
The drug is applied in a thin layer; it should not be rubbed into the skin. The product should be absorbed into the skin on its own.
The frequency of use of the drug is 1 time every 8-12 hours.
The gel is not recommended for use under bandages that do not allow air to pass through.
Strictly ensure that the gel does not get on the mucous membrane of the eyes. If your eyes come into contact with the gel, rinse them a large number clean water.
After using the gel, you should wash your hands thoroughly with water and soap.
After using the drug, the tube with the gel should be tightly closed.

Contraindications

Like all medications, Nise has a number of contraindications, including:

- hypersensitivity to one of the components of the gel;
- acute damage to the digestive system by ulcers or erosions;
- stomach/intestinal bleeding;

- dermatoses of various etiologies, damage to the upper layers of the skin;
- infectious skin diseases;

violation of the integrity of the skin at the site of application of the gel;
acute renal failure;
pathological processes in the hematopoietic system;
bronchospasms caused by the use of others in the anamnesis;
period of bearing a child;
breastfeeding period;
age of patients under 7 years.

Nise Gel is used with extreme caution for cardiovascular pathologies, hypertension, diabetes mellitus Type 2, elderly patients.

Side effects

Side effects when using Nise Gel externally quite small, but, nevertheless, they take place.
Rarely, occur local reactions in the form of itching, urticaria, peeling of the skin, discoloration of the skin at the site of application of the drug, burning sensation. Similar side effects As a rule, they do not require discontinuation of the drug and go away on their own within a few days.

Using the gel on a large area of skin or prolonged use may cause a number of systemic reactions, such as:

burning sensation in the larynx, behind the sternum;
feeling of nausea with bouts of vomiting;
digestive disorders;
formations on the mucosa digestive tract ulcers and minor erosions;
increased activity of liver transaminases;
migraine and headache;
feeling dizzy;
fluid retention in the body;
manifestation of allergic reactions, up to anaphylactic shock;
thrombocytopenia, anemia, leukopenia and other abnormalities in blood tests.

If any of the above symptoms occur, you should stop using the drug and seek help from your doctor.

Overdose

The official instructions for the drug do not contain data on cases of overdose. The only thing to remember is the risk of systemic side effects that can develop with a single dose of the drug in a dosage of 50g or more. Since there is no specific antidote, if an overdose is suspected, seek medical advice. urgent help medical workers.

Use during pregnancy and lactation

The use of the gel by women carrying a fetus is prohibited. To treat joint pain in this case, you should consult a gynecologist who recommends analogues of the drug. If there is an urgent need to use Nise Gel during lactation, breastfeeding must be interrupted for the entire period of therapy.

Drug interactions

Nise Gel should be used with caution simultaneously with phenytoin, digoxin, drugs containing lithium, cyclosporine, diuretics, etc. non-steroidal drugs anti-inflammatory effects, antihypertensive drugs and hypoglycemic drugs. If the patient uses such medications, this must be reported to the attending physician who prescribes the use of the drug.

Advantages

Comparing Nise Gel with its analogues, a number of advantages can be identified:

Clinical trials of the product have shown that it is as safe as possible for use(except for cases falling under “contraindications”). Gradual absorption of active substances into muscles and synovial joint fluid provides a low concentration of components in the blood. When using this medicine according to the instructions, it does not have any negative influence on the body. All components are completely eliminated from the body by the liver..
Nise Gel meets all requirements, which, according to WHO, drugs must comply with local application, namely:

the drug has analgesic properties, which provides high efficiency therapy;
absence of local toxic reactions, allergic manifestations which the medicine may cause;
the ability to quickly reach the “hearth”, being absorbed through the layers of the skin;
the concentration of the components of the drug in the blood does not reach the level where there is a risk of side effects;
the exchange and excretion of the drug from the body are the same as for systemic use.

Price

The average price of Nise Gel 20 mg is 160-190 rubles;

The average price of Nise Gel 50 mg is 300-315 rubles.

Conditions for dispensing the drug

Nise Gel is a drug that can be purchased in pharmacy chains without a prescription.

Storage

The gel is stored in a tightly closed tube away from direct sun rays. The storage temperature of the drug should not exceed 24°C. It is impossible to allow the product to freeze, since in this case it loses all its medicinal properties.

The drug should be kept out of the reach of children.

Best before date

The drug is suitable for use within 24 months from the date of its manufacture, the date of which is indicated on the cardboard packaging.

Analogues

In terms of the active substances included in the drug, Nise Gel has the following analogues:

Sulaydin.

In terms of therapeutic effects, the following analogues of the drug exist:

Bioran Gel;
etc.

It should be noted that the use of Nise Gel and its analogues must be agreed with a specialist.

Reviews

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Efficiency

Price

Easy to find in pharmacies

Side effects

Semyon

4 months ago

Efficiency

Thanks to the substance nimesulide, the product for external use eliminates muscle pain and is used in the treatment of osteoarthritis and other diseases of the musculoskeletal system. Before use, you should read the instructions, especially the contraindications - Nise Gel is not used for itching and damage skin. The drug has 3 actions necessary in the fight against pain - it lowers fever, relieves inflammation, and relieves pain.

Nise gel - instructions for use

Medicinal gel for external use belongs to non-steroidal anti-inflammatory drugs (NSAIDs). The new generation product has an anti-inflammatory and analgesic effect. Nise shown for local symptomatic treatment degenerative and inflammatory diseases musculoskeletal system. The ointment comes in compact tubes that you can carry with you. Nise is applied to the dry affected area in a thin layer and improvement occurs within a day.

Compound

One gram of Nise - a means for external use, contains nimesulide as the main active ingredient. The anti-inflammatory and analgesic effect of the gel is due to nimesulide. In addition to distilled water, flavoring, thimerosal, isopropanol, bottled hydroxyanisole, the following substances are the auxiliary ingredients of Nise:

propylene glycol;
N-methyl-2-pyrrolidone;
PEG-400;
carbomer-940;
potassium phosphate.

Release form

The medicine Nise is available in aluminum tubes of 20, 50 g. Each tube is sold in cardboard box with attached instructions for use. It appears to be a transparent gel without foreign particles of a white or pale yellow hue. The drug Nise is available in the form of a suspension for oral administration and white tablets with yellow tint. The tablets appear to be round, biconvex, with a smooth surface.

Pharmacodynamics and pharmacokinetics

The ointment belongs to the anti-inflammatory painkillers from the sulfonamide class. Nimesulide has local action, reduces the concentration of pain mediator. At local application promotes the disappearance of pain at rest and during movement, reduces morning stiffness of joints. The maximum concentration of nimesulide after a single use is achieved by the end of the first day. Its value is 300 times greater than when using oral forms of nimesulide. When applying the gel, the concentration active substance in the systemic circulation is extremely low.

Gel Nise - indications for use

In most cases, the drug is used for joint pain. At the site of application, the gel has an anti-inflammatory effect, eliminates pain and is indicated for external local use. The ointment eliminates pain symptoms in the muscles and spinal column of unknown origin. The medication is used for pathologies of the spinal nerve roots (radiculitis), diseases of the joints and tissues (gout). According to the instructions, other indications for the use of the gel include:

Bechterew's disease (inflammation of the intervertebral joints);
bursitis;
inflammation of ligaments and tendons (tendinitis);
rheumatism;
synovitis (inflammation of the synovial membrane);
tenosynovitis (acute or chronic inflammation tendon sheath);
lumbodynia (lower back pain);
myalgia ( muscle pain);
arthritis;
neuralgia;
osteoarthritis;
osteoarthritis.

Contraindications

The gel should be used with caution in elderly patients, people with cardiovascular pathologies, type 2 diabetes mellitus, hypertension (with increased blood pressure). The drug Nise has a number of contraindications, the list of which must be studied before using the gel. The medication is not used in case of hypersensitivity to the components of Nise. Other contraindications of the gel include:

childhood up to 7 years;
violation of the integrity of the skin;
breastfeeding period;
acute renal failure;
pregnancy;
pathologies in the hematopoietic system;
bronchospasms (caused by the use of NSAIDs - non-steroidal anti-inflammatory drugs in the anamnesis, medical history);
skin infections;
erosion or stomach ulcers;
damage to the upper layers of the skin, dermatoses;
intestinal or stomach bleeding.

The gel is intended for external use. During treatment pain syndromes the drug must be used according to the official instructions. It is necessary to observe the frequency of use and the recommended dosage according to indications. The area to be applied should be washed with soap and water, and then the surface of the skin should be dried. The multiple dosage is no more than 3 cm of squeezed gel. Other recommendations for use:

Nise is applied in a thin layer to the surface of the skin without rubbing.
The frequency of use is 1 time every 8-12 hours, 2-3 times a day.
The course of treatment is no more than 10 days.

Nise - side effects

When using the gel, there are few side effects, but they do exist. In rare cases, local reactions occur, such as a burning sensation, itching, urticaria, change in skin color at the site of application of Nise, peeling of the skin. Similar symptoms disappear on their own within 24 hours and after discontinuation of the drug. Long-term use of the gel and application over a large area of skin cause a number of systemic reactions, if they occur, you should consult a doctor:

leukopenia;
burning sensation behind the sternum and in the larynx;
anemia;
nausea with bouts of vomiting;
thrombocytopenia (a condition of low platelet count);
digestive disorders;
allergic reactions(anaphylactic shock);
formation of small erosions and ulcers on the mucous membrane of the digestive tract;
fluid retention in the body;
increased activity of liver transaminases (enzymes);
dizziness;
headache;
migraine.

Overdose

According to the official instructions for use of Nise, there is no data on overdose. For single use large quantity gel (from 50 g), the risk of developing systemic side effects cannot be excluded. There is no specific antidote, so if you suspect an overdose of the drug, you should seek urgent medical attention. medical care.

Special instructions

The instructions for use of Nise indicate that the drug should not be applied under airtight bandages. After use, close the tube tightly and wash your hands thoroughly with soap. Contact with mucous membranes and eyes should be avoided. Otherwise, you need to rinse the area clean water and consult a doctor. The gel is applied only to an intact area of skin, without open wounds.

During pregnancy and breastfeeding

According to the instructions, the use of Nise by women carrying a fetus is strictly prohibited. If it is necessary to treat pain in the joints, you should consult a gynecologist about prescribing analogues of the drug approved during pregnancy. If there is an urgent need to use the gel during lactation, then breast-feeding stop for the entire therapeutic course.

Nise for children

If you need to use the product for children, you should consult a pediatrician. The instructions contain information that Nise is contraindicated for children under seven years of age. For a child over 7 years old, an anti-inflammatory drug is prescribed with caution.

For impaired renal and liver function

The gel should be prescribed with caution to patients with renal and hepatic insufficiency. According to the instructions, the drug for external use is contraindicated in renal failure severe, with creatinine clearance (an indicator that evaluates kidney function) less than 30 ml/min.

Drug interactions

The medication should be used with caution when used together with hypoglycemic drugs (antidiabetic), antihypertensive drugs (lowering blood pressure), non-steroidal anti-inflammatory drugs, diuretics. When using antiepileptic drugs with phenytoin, antiarrhythmic drugs with digoxin, powerful immunosuppressants with cyclosporine and drugs containing lithium, you must inform your doctor prescribing Nise.

Terms of sale and storage

Nise – over-the-counter drug, which can be purchased over the counter without a prescription, but it is important to consult a doctor before use. Nise must be stored at room temperature (not higher than 24 degrees) in the original tube, tightly closed. The storage location should not be exposed to direct sunlight and be accessible to children. When the product is frozen, the gel loses all its healing properties. Shelf life – 2 years from the date of manufacture indicated on the cardboard packaging.

Nise gel - the latest description of the drug, you can read the contraindications, side effects, dosage of medicine Nise gel. Reviews of Nise gel -

NSAIDs for external use.
Drug: NIZE®
Active substance of the drug: nimesulide
ATX encoding: M02AA
KFG: NSAIDs for external use
Registration number: P No. 012824/02
Registration date: 06.20.08
Owner reg. cred.: DR. REDDY`S LABORATORIES LTD. (India)

Nise gel release form, drug packaging and composition.

Gel for external use 1% transparent, light yellow or yellow, free from foreign particles.

1 g
nimesulide
10 mg

Excipients: N-methyl-2-pyrrolidone, propylene glycol, macrogol, isopropanol, carbomer 940, butylated hydroxyanisole, thimerosal, potassium phosphate, water, flavor.

20 g - aluminum tubes (1) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

Pharmacological action Nise gel

NSAIDs for external use. It has a local analgesic and anti-inflammatory effect.

Nimesulide - selective competitive reversible inhibitor COX-2 (endoperoxide prostaglandin H2 synthetase). Reduces the concentration of short-lived prostaglandin H2, a substrate for kinin-stimulated synthesis of prostaglandin E2, at the site of inflammation and in the ascending pathways of pain impulses in the spinal cord.

A decrease in the concentration of prostaglandin E2 (a mediator of inflammation and pain) reduces the activation of EP type prostanoid receptors, which is manifested by analgesic and anti-inflammatory effects.

When applied topically, it causes a weakening or disappearance of pain at the site of application of the gel, incl. pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints. Helps increase range of motion.

Pharmacokinetics of the drug.

Data on the pharmacokinetics of the drug are not provided.

Indications for use:

Articular syndrome with rheumatism and exacerbation of gout;

Rheumatoid arthritis;

Psoriatic arthritis;

Ankylosing spondylitis;

Osteoarthritis;

Osteochondrosis with radicular syndrome;

Radiculitis;

Inflammation of ligaments, tendons, bursitis;

Lumbago;

Myalgia of rheumatic and non-rheumatic origin;

Post-traumatic inflammation of soft tissues and the musculoskeletal system (damage and rupture of ligaments, bruises).

Dosage and method of administration of the drug.

Before using the gel, wash and dry the skin surface. Apply a strip of gel approximately 3 cm long in an even thin layer, without rubbing, to the area of maximum pain 3-4 times a day.

The amount of gel and the frequency of its use (no more than 4 times a day) varies depending on the size of the skin area being treated and the patient’s reaction.

The maximum dose is 5 mg/kg/day (30 g/day). The duration of use of the drug is no more than 10 days without consulting a doctor.

Side effects of Nise gel:

When applying the gel to large areas of skin, systemic symptoms may develop. adverse reactions.

From the outside digestive system: heartburn, nausea, vomiting, pain in the stomach, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, increased activity of liver transaminases.

From the side of the central nervous system: headache, dizziness.

From the hematopoietic system: thrombocytopenia, leukopenia, anemia, agranulocytosis, prolongation of bleeding time.

From the urinary system: fluid retention, hematuria.

Allergic reactions: skin rash, anaphylactic shock.

Local reactions: itching, urticaria, peeling, transient change in skin color (does not require discontinuation of the drug).

If any adverse reactions occur, you should stop using the drug and consult your doctor.

Contraindications to the drug:

Pregnancy;

Lactation period (breastfeeding);

Dermatoses, damage to the epidermis, skin infections in the area of application;

Hypersensitivity to nimesulide and other components of the drug.

The drug should be prescribed with caution when erosive and ulcerative lesions Gastrointestinal tract, liver failure, renal failure (KK<30 мл/мин), застойной сердечной недостаточности, артериальной гипертензии, «аспириновой» астме, сахарном диабете типа 2 (инсулиннезависимом), у пациентов детского возраста младше 12 лет.

Use during pregnancy and lactation.

Nise is contraindicated for use during pregnancy and lactation.

Special instructions for use of Nise gel.

The drug should be applied only to intact areas of the skin, avoiding contact with open wounds. Avoid contact of the gel with the eyes and other mucous membranes, as well as use with airtight bandages.

After applying the gel, you should wash your hands with soap. The tube should be tightly closed after using the gel.

Drug overdose:

Currently, no cases of overdose of Nise have been reported.

When applying more than 50 g of gel to large areas of the skin, an overdose may develop (systemic adverse reactions).

There is no specific antidote. You should immediately consult a doctor.

Interaction of Nise gel with other drugs.

Manifestations of pharmacokinetic interaction are possible (due to competition between drugs for binding to proteins) while taking Nise orally with digoxin, phenytoin, lithium drugs, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, and oral hypoglycemic agents.

Terms of sale in pharmacies.

The drug is approved for use as an over-the-counter product.

Storage conditions for the drug Nise gel.

List B. The drug should be stored out of the reach of children at a temperature not exceeding 25°C; do not freeze. Shelf life: 2 years.

Nise is an anti-inflammatory drug that can have antipyretic, antiplatelet and analgesic effects. Prescribed for inflammatory diseases. The drug belongs to the pharmacological group of NSAIDs, the main active ingredient is nimesulide.

Nise is intended for both oral and external use. Available in the form of tablets, lozenges, dispersible tablets, soluble tablets, suspension, granules (for suspension), granules (for solution), gel.

One tablet contains the main active ingredient - nimesulide - in an amount of 100 milligrams (and the dispersible tablet contains 50 milligrams) and excipients such as calcium phosphate, magnesium stearate, corn starch, talc, pineapple flavor, colloidal silicon dioxide, microcrystalline cellulose, calcium carboxymethyl starch .

Five milliliters of suspension contain the main active ingredient - nimesulide - in an amount of 50 milligrams and excipients such as purified water, sorbitol, pineapple flavor, glycerol, methylparaben, sucrose, polysorbate 80, propylparaben, citric acid, gum, yellow quinoline dye W.S. . The suspension has a characteristic taste and pleasant odor, yellow color.

One percent gel, contains the following excipients: water, thimserosal, propylene glycol, flavoring, isopropanol, potassium phosphate, butylated hydroxyanisole, N -methyl-2-pyrrolidone, carbomer-940, PEG-400.

Indications for use Nise

Nise is recommended for use in the following diseases: tendinitis, bursitis, pain syndrome, radiculitis, Bheterov's disease, febrile syndrome, myalgia, algodismenorrhea, neuralgia, inflammation of soft and bone tissues due to injury, arthritis, osteochondrosis (mainly with radicular syndrome), articular syndrome (for example, with gout), lumbago, sciatica, osteoarthritis, inflammation of ligaments and tendons.

Contraindications to the use of Nise

Nise is contraindicated in patients suffering from hypersensitivity to the components of this drug, peptic ulcers of the stomach or intestines, liver and kidney failure, gastric or intestinal bleeding, aspirin-induced asthma, heart failure, arterial hypertension, and type 2 diabetes mellitus. It is prohibited to take Nise in the third trimester of pregnancy, during lactation, for patients under 12 years of age (for tablets), for patients under 2 years of age (for suspensions). The gel is contraindicated in the presence of open lesions, dermatosis and other skin lesions on the area.

Nise Use during pregnancy and children

Contraindicated during pregnancy and breastfeeding.

Drug interactions

Caution should be exercised when using nimesulide simultaneously with the following drugs (due to the drugs competing for binding to plasma proteins): digoxin, phenytoin and lithium drugs, diuretics and antihypertensive drugs, other NSAIDs, cyclosporine, methotrexate and antidiabetic drugs, anticoagulants (dispersible tablets). Pills. The effect of medications that reduce blood clotting is enhanced when used simultaneously with nimesulide. Nimesulide may reduce the effect of furosemide; increase the development of side effects while taking methotrexate. Plasma lithium levels increase when lithium and nimesulide are taken simultaneously. Use with GCS and SSRIs increases the risk of gastrointestinal bleeding.

Nise dosage

Nise is taken internally or externally. Tablets, suspension, granules for suspension and solution are intended for oral use. The gel is intended for external use.

It is recommended to take the tablets before meals, however, if discomfort in the stomach was recorded after taking it, it is permissible to take the drug after meals. Patients over 12 years of age are prescribed from 200 to 400 milligrams per day (2-4 tablets), one tablet per dose.

Dispersible tablets are pre-dissolved in water (a teaspoon of water is required per tablet). For patients aged 3 to 12 years, the required dose of the drug is calculated based on body weight. Patients over 12 years of age are prescribed 100 milligrams (2 tablets) per dose, twice a day.

The suspension can be taken by patients over 2 years of age; for them, the dose of the drug is calculated based on body weight, as well as for all adolescents whose body weight does not exceed 40 kilograms. For patients whose body weight exceeds 40 kilograms, the daily dose is 200-400 milligrams of the active substance (20-40 milliliters of suspension).

The gel is applied directly to the painful area, the skin of which has been thoroughly washed and dried. The gel is applied to the most painful area in a column three centimeters long, after which it is carefully distributed over the painful area in a thin layer (without rubbing). The procedure is carried out 3-4 times a day.

The maximum course of use of the drug Nise is 10 days; it is not recommended to exceed the time of taking Nise.