Sinusitis

Can Nise gel be applied to the neck? General characteristics

Painful sensations, regardless of their origin, cause a lot of inconvenience to a person. The situation is aggravated if the problem is localized in the area of soft tissues and joints. In such cases, the body becomes stiff, and every movement causes pain.

What to do, who to turn to for help, and is it possible to get rid of these symptoms at all? It turns out that the simplest and effective way the solution to the problem is right before your eyes - instructions for use nise gel.

Nise gel is a local non-steroidal medicine that helps cope with pain and fever in diseases of various etiologies. It is actively used in the treatment of bursitis, osteoarthrosis, tendovaginitis, osteoarthritis, as well as a number of other ailments inflammatory in nature. Received the drug widespread, both for doctors and patients.

Nice gel features:

Clinical studies have confirmed that the medication is absolutely safe.
A nominal amount of active substances penetrates the surface of the skin into the main bloodstream.
The maximum concentration in the body is formed only 24 hours after using the gel.
The drug composition does not affect chemical composition blood plasma.

The medication does not accumulate in tissues, joints or internal organs, and is completely excreted through the liver.

Pharmacological group and action

Nise ointment belongs to the big pharmacological group non-steroidal anti-inflammatory drugs (sulfonanilide class) local action(NSAIDs). After application to the problem area of the body, it eliminates inflammatory processes in the joints, soft tissues, relieves painful symptoms. The main active ingredient of the drug is nimesulide, which causes a therapeutic, analgesic effect.

Mechanism of action of the drug:

Prevents the synthesis of prostaglandin in the lesion inflammatory process(without this element the formation of edema is impossible, painful sensations).
Inhibits COX, acting selectively on problem areas. IN in rare cases affects healthy cells.
Menthol in the composition of the medication helps to activate cold receptors, resulting in a calming effect.
Articular and bone tissue receive recharge in the form of calcium ions, thanks to which the affected area is quickly saturated with nutrients and oxygen.

Methyl salicylate increases the intensity of blood flow at the site of application (after hydrolysis), suppresses biochemical processes associated with the formation of edema and severe pain (including lipid oxidation). Due to which there is a local anti-inflammatory and analgesic effect, the amplitude and range of movements gradually increases

Release form and composition

The pharmaceutical drug is available in the form of a white translucent gel (for some manufacturers the color is shifted towards yellow tones). It is a homogeneous, medium-thick consistency without any foreign inclusions or substances. Available for sale in aluminum tubes of 20 and 50 g. Supplied in a separate cardboard box with annotation.

Nise composition The gel includes 4 active substances (per 1 g of product):

A number of excipients are also present: thimerosal, macrogol, isopropanol, carbomer 940, propylene glycol.

Storage conditions and shelf life of the drug

The gel is prescribed to be stored in a dark place at a temperature of 24 °C; it is important to avoid contact of the aluminum tube with direct sun rays, sources of moisture. When placed in the refrigerator and frozen, the drug loses its declared properties.

The shelf life in a sealed tube, subject to the above requirements, is 24 months from the date of manufacture indicated on the cardboard box. If the tube is damaged, the thickness of the consistency, color changes, or a pronounced odor appears, use of the medicine is strictly prohibited!

Instructions for use

It is necessary to use a pharmaceutical drug for the treatment of joint pain as prescribed by a doctor. At independent use composition, it is important to read the instructions for applying the Nise gel in detail. To achieve the desired effect, it is recommended to strictly adhere to the indicated dosage and frequency of procedures.

There is only one method of use for the drug - external, local.

Step by step instructions:

The area where the gel is applied is washed with soap and water, if possible treated with an antiseptic, and wiped dry with a towel.
The medicinal composition is applied only to “clean” skin, without inflammation, damage or ulcers.
The recommended amount of gel for application to the surface of the skin is up to 3 cm (3 g) for 1 procedure.
Medium thickness consistency evenly distributed over problem area, forming a thin layer of coating. Healthy skin not processed!
It is forbidden to rub the drug into the epithelium; the absorption process occurs naturally without outside intervention.
An anti-inflammatory, antipyretic agent is applied 1-3 times a day (every 8-12 hours), every day (no more than 10 days).

After applying the medication to the surface of the skin, it may cause itching and burning. It stops without patient intervention after 2-4 minutes. The duration of treatment is determined by the doctor, based on the characteristics of the pathology and accompanying symptoms.

Indications for use

A feature of the Nise gel is wide range actions. It is used to combat ailments musculoskeletal system, relief of painful sensations that develop against the background of increased body temperature.

Main indications for use:

Often Nise ointment prescribed for bruises, injuries, injuries, bruises, inflammations localized in cartilage and bone tissues.

Contraindications and side effects

There is not a single pharmaceutical drug that does not have contraindications. Nise gel also has restrictions on its use.

It is prohibited to apply the composition when:

open wounds, active inflammatory processes accompanied by purulent discharge;
severe renal failure;
high sensitivity to active or auxiliary substances;
internal bleeding localized in the stomach area;
extensive lesions digestive tract ulcers;
problems with blood formation;
children under 7 years of age.

Elderly patients diagnosed with hypertension, diabetes mellitus (type 2), and pathologies of the cardiovascular system should exercise extreme caution when applying the medicine.

Overdose is often accompanied by side effects (despite the lack of officially confirmed data):

migraine attacks;
erosive formations on the gastric mucosa;
nausea followed by vomiting;
burning;
problems with blood formation;
expressed allergic reactions;
local swelling;
dizziness.

If after taking the medication the patient experiences an unpleasant sensation or one of side effects, subsequent use of the medication should be discontinued. It is equally important to apply for timely medical care.

Use during pregnancy and lactation

Pregnant women are strictly prohibited from applying Nise Gel. To prevent joint pain, substitutes or analogues are used as prescribed by a doctor. Similar restrictions are imposed during lactation. If there is an urgent need to use the particular composition in question, breastfeeding is stopped until the end of the therapeutic course.

Interaction with other drugs

Nise gel is used with extreme caution if the patient is already prescribed the following drugs: lithium-containing drugs, NSAIDs, digoxin, phenytoin, cyclosporine, hypoglycemic and antihypertensive drugs. Required in mandatory notify the attending physician (if there are several, consult with each).

Directions for use and doses

Nise cream, in accordance with the instructions, is used exclusively externally. The safe dose when applying the composition is a strip 2.5-3 cm long. For children - 1.5-2 cm. Use the composition 3 to 4 times a day (children - 1 to 3 times). Treatment is limited in time to 10 days. If there is no positive dynamics within 7 days, it is recommended to consult a doctor to adjust the therapeutic course.

Special instructions

Nise ointment is applied only to clean and undamaged skin. It is important to avoid contact of the drug with open wounds, mucous membranes. It is strictly forbidden to take the medication orally.

A few important instructions:

The gel is not intended for children under 7 years of age.
Applying sealed and tight bandages with the medication in question is taboo.
After applying the thick consistency to the problem area, screw the tube cap tightly.
Before and after the procedure, hands are thoroughly washed with antibacterial soap.

It is safest to fight the disease under the supervision of a specialist. A personal treatment and therapy regimen must be prepared for each patient.

Belonging to the class of sulfonanilides. According to the classification, the drug belongs to the group of non-narcotic painkillers and anti-inflammatory drugs. The gel has a pronounced analgesic effect and is used for various types arthritis and other lesions of the musculoskeletal system to eliminate pain.

Dosage form

The product is produced in the form of a gel intended for external use, sold in tubes of 20 and 50 grams.

Description and composition

The drug is produced in tubes of 20 and 50 grams. The product has a white or pale yellow color and a uniform consistency - the presence of foreign particles is unacceptable.

The drug contains the following substances:

methyl salicylate;
matanol;
capsaicin.

The list of auxiliary components includes:

distilled water;
sodium benzoate;
disodium salt of ethylenediaminetetraacetic acid;
trometamol;
hydroxytoluene;
polyoxylcastor oil;
monoethyl diethylene glycol ether;
propylene glycol;
diethyl phthalate;
non-toxic gelling agent carbomer.

Pharmacological group

The gel belongs to the group of non-steroidal anti-inflammatory drugs, latest generation. The main active component is, which has a local analgesic effect. The composition has a local antipyretic effect, removing heat from the affected areas.

Methanol has analgesic and antipruritic effects. The effectiveness is due to the ability of the composition to irritate nerve endings, skin receptors and mucous membranes. Provides the production and release of substances involved in the processes of pain regulation.

Methyl acylate ensures increased blood circulation in the affected areas. The component eliminates swelling and relieves inflammation. The product reduces the intensity of painful sensations. Often, during use, allergic reactions occur that do not require stopping the use of the product.

Indications for use

The list of indications for use of the product is as follows:

bursitis;
synovitis;
lumbodynia;
arthritis;
osteoarthritis;
osteoarthrosis;
tendenitis;
nerve damage, various neuralgia;
myalgia;
defeats inner shells vaginas in women;
Bekhterev's disease;
rheumatism;
damage to joints and tissues manifested against the background of metabolic processes;
radiculitis;
pain manifested in the spinal column.

for adults

The gel product can be used in patients belonging to these groups who do not have contraindications to the use of the composition.

for children

The use of the composition in pediatrics is prohibited. If there are acute indications, the composition can be used for children over 7 years of age. The patient's well-being in this case should be constantly monitored. Manifestation adverse reactions– a good reason to refuse to use the product.

Gel for external use is not recommended for use during pregnancy; the active component of the composition has the ability to be absorbed into the systemic bloodstream. Using the product can cause various developmental defects in a child. Use of the product during pregnancy is not recommended.

Contraindications

All medications have a certain list of contraindications for use, and the gel is no exception. The list of contraindications includes:

hypersensitivity to the active or auxiliary components of the composition;
ulcerative or erosive lesions of the gastrointestinal tract;
stomach bleeding;
lesions of the epidermis at the site of application;
infectious skin lesions;
violation of the integrity of the skin at the site of use of the product;
acute renal failure or its chronic course;
pathologies of the hematopoietic organs;
pregnancy period;
childhood.

Increased caution is required when using the product in patients with the following lesions:

hypertension;
heart rhythm disturbances;
insulin-dependent diabetes;
old age.

The use of the product in the presence of contraindications is unacceptable. In this case, the actions will cause significant harm.

Applications and dosages

Before using the product, rinse thoroughly clean water treated area. The area where the product is applied must be free of damage. A single dosage per day should not exceed 3 cm. Apply the product only to the area with severe pain. The drug should be absorbed on its own; you should not rub it into the skin. There is also no need to use bandages; it is important to provide air access.

for adults

The product is applied to previously prepared areas of the skin. The daily dose of use is 3-4 times a day. Maximum duration course of therapy 1-2 weeks.

for children

for pregnant women and during lactation

The use of the product during pregnancy and breastfeeding is strictly prohibited. If there is an urgent need to use the composition during lactation, the issue of transferring the child to formula milk is decided.

Side effects

Adverse reactions with the use of the gel are extremely rare. If the patient has hypersensitivity to the components of the product, an allergy may develop:

peeling of the skin;
itching of the skin;
change in skin color;
burning sensation.

Reactions of this nature do not require discontinuation of the drug and disappear on their own.

Adverse reactions from the following list occur extremely rarely, in particular with prolonged and improper use:

a feeling of tightness behind the sternum;
burning sensation in the larynx;
digestive disorders;
headache and migraine;
dizziness;
nausea and;
delayed diuresis;
anemia.

If these symptoms occur, you should seek emergency medical help. In some cases, emergency refusal to use the product and its subsequent replacement is indicated. In rare cases, with prolonged use of the gel, renal failure develops, the symptom of which is disruption of the processes of removing fluid from the body.

Interaction with other drugs

It has the ability to enhance the effect of agents that inhibit the blood clotting process. Reduces the effectiveness of antihypertensive compounds and diuretics. It is not recommended to use in combination with. may increase the concentration of lithium in the patient's blood. Enhances the activity of cyclosporine.

Special instructions

Scroll special instructions looks like this:

The drug can be applied to intact skin.
Avoid contact of the composition with mucous membranes.
The drug is used exclusively externally. After use, you should wash your hands; you can use disposable gloves for application.

The composition does not affect psychomotor reactions and the ability to concentrate.

Overdose

Cases of overdose are not recorded in the official medical practice. Development risk unwanted effects increases due to non-compliance with recommended doses and rules of use. An overdose is manifested by a general deterioration in health: nausea, clouding of consciousness. An elevated temperature often occurs. A specific antidote has not been found; if you suspect an overdose, you should contact a specialist urgently. For oral consumption, gastric lavage is indicated. emergency hospitalization, hemodialysis may be used.

Storage conditions

The drug is sold to the public through a network of pharmacies for free sale; a prescription from a doctor is not required. The product should be stored in its original packaging for two years from the date of issue. The room temperature should not exceed 25 degrees. Children's access to the place where medicines are stored should be limited.

Nise is a non-steroidal drug used for inflammation. This medicine reduces swelling, pain and helps normalize body temperature. Widely used to eliminate manifestations of inflammatory reactions in diseases of the musculoskeletal system and injuries.

Nise comes in tablet and gel form. His active ingredient The substance is nimesulide.

The tablets have a flat-cylindrical biconvex shape. They are smooth to the touch, the color is almost white with a subtle yellowish tint. One tablet contains 100 mg active component.

They contain the following excipients:

calcium hydrogen phosphate;
cellulose with microcrystalline structure;
starch obtained from corn grains;
talc;
magnesium stearate;
sodium carboxymethyl starch;
colloidal silicon dioxide.

Each blister contains 10 tablets. A cardboard pack may contain 1, 2 or 10 blisters. Also produced dissolvable tablets"Nise Kid", designed primarily for children. Quantity active substance they contain 50 mg.

Gel is a thick translucent substance yellow, free from visible impurities. The concentration of nimesulide is 1%. Additional components of the gel are:

macrogol;
N-methyl-2-pyrrolidone;
propylene glycol;
isopropanol;
carbomer;
thiomersal;
butylated hydroxyanisole;
potassium dihydrogen phosphate;
aromatic component "narcissus-938";
water.

The gel is produced in laminated tubes made of aluminum. Their capacity can be 20 or 50 g. The tube with the gel is placed in a cardboard pack.

There is another form of the drug - granules intended for preparing a medicinal suspension. This form of medication is optimal for treating children.

What is it used for?

The use of the drug is indicated for:

arthritis (including rheumatoid and psoriatic);
radiculitis;
lumbago;
sciatica;
osteochondrosis;
presence of radicular syndrome;
bursitis;
osteoarthritis;
arthralgia;
ankylosing spondylitis;
inflammatory diseases ligaments and tendons;
myalgia (both rheumatic and non-rheumatic in nature);
inflammatory processes in soft tissues caused by bruises, sprains, ligament ruptures and other injuries;
pain resulting from injuries and after surgery;
headache, dental, periodic female pain;
febrile conditions, including against the background of infectious and inflammatory diseases.

The use of this product is effective when acute phases inflammation, accompanied by pain, swelling and fever.

Pharmacological action

Nise is a non-steroidal anti-inflammatory drug belonging to the sulfonanilide class. At its core, nimesulide, on which the action of the drug is based, is a selective inhibitor of COX-2 (an enzyme necessary for the synthesis of prostaglandins responsible for the development pain manifestations, swelling and inflammatory reactions).

Reversible suppression of prostaglandin E2 synthesis is observed not only in the area of inflammation, but also in the pathways of pain impulses located in the tissues spinal cord. Thanks to these properties, the drug promotes:

removing or reducing the severity of inflammation;
pain relief;
reducing elevated body temperature.

In addition, contained in medicine active substance slows down the reactions of synthesis of endoperoxides and thromboxane A2 and prevents the activation of plasminogen. This prevents the release of histamine and may reduce the severity of bronchial spasm.

The medicine slows down the effect negative factors leading to necrotic tissue changes.

Nise significantly slows down the synthesis reactions of interleukin-6, urokinase and metalloprotease, which helps prevent the destruction of cartilage tissue.

Studies have confirmed that the drug has an antioxidant effect and also promotes the activation of glucocorticoid receptors. This further enhances its therapeutic effect.

After entering the digestive tract, the tablets are well absorbed into the blood. Eating food reduces the rate of absorption, but its extent does not change. The maximum concentration of nimesulide in the blood is observed 1.5-2.5 hours after taking the medicine. The degree of binding to blood plasma proteins reaches 95%.

At the site of inflammation, the concentration of the drug is about 40% of that found in the plasma. Approximately the same high content is observed in the synovial fluid and in the female genital organs. The drug passes through the histo-hematological barriers almost unhindered.

In the liver, the drug undergoes intensive metabolism. The main metabolite is 4-hydroxynimesulide (about 25%), which has similar pharmacological properties.

The half-life of nimesulide varies between 1.5-5 hours, and 4-hydroxynimesulide - 2.9-4.8 hours. Approximately 65% of metabolites are excreted through the kidneys and 35% along with bile.

The effect of the gel is local, it is limited to the area of its application.

Instructions for use

Pills

The tablets are best taken before meals, and for patients with illnesses gastrointestinal tract It is recommended to consume them immediately after meals. An adult should drink 100 mg of the drug (1 tablet) 2 times a day. If necessary, the daily dose can be increased to 400 mg. Course of treatment without special purpose doctor should not exceed 10 days.

Gel

The gel is evenly applied in a thin layer to the skin in the affected area (you should squeeze out a strip approximately 3 cm long, but this amount may differ from that given depending on the area of pain). It should be applied without physical effort, without rubbing. It can be used a maximum of 3-4 times a day.

Before applying the gel, the area of skin in the painful area must be washed and wiped dry. You should not use the gel for more than 10 days in a row without appropriate medical advice.

Ointment

Nise is not available in ointment form. Often an ointment is mistakenly called a gel.

Contraindications and side effects

Nise should not be used for:

erosions, ulcerative lesions and inflammatory diseases of the digestive tract in the acute phase;
tendency to gastrointestinal bleeding;
increased likelihood of developing other internal hemorrhages;
liver diseases accompanied by serious disturbances in its functioning;
severe forms of renal failure or progressive kidney disease;
a history of bronchospasm caused by taking acetylsalicylic acid or another non-steroidal anti-inflammatory drug;
severe heart failure in the stage of decompensation;
hyperkalemia;
diseases, causing disruption blood clotting (including hemophilia);
alcohol or drug addiction;
hypersensitivity to nimesulide or to the auxiliary components of this medicine;
pregnancy;
breastfeeding.

If the patient has undergone coronary artery bypass surgery, use the drug in recovery period forbidden.

If there are serious chronic diseases This product can only be used as prescribed by a doctor, observing necessary measures precautions.

The drug may cause the following side effects:

problems with functioning digestive system(abdominal pain, heartburn, nausea, vomiting, diarrhea);
formation of erosions and ulcers of the gastrointestinal tract;
increased concentration of liver enzymes in the blood;
toxic hepatitis;
reactions from the central nervous system (headache, dizziness, drowsiness);
kidney failure;
retention of excess fluid in the body;
increased duration of bleeding;
deterioration of blood analysis indicators;
allergic reactions (skin rashes, urticaria, anaphylactic shock, bronchospasm);
skin itching, peeling and change in skin color (when using the gel).

If side effects occur, you should stop taking the medicine and tell your doctor. It should be borne in mind that the gel long-term use over large areas can lead to the same systemic side effects as when using forms of the drug intended for oral use.

Application for children

Tablets of 100 mg can be prescribed from 12 years of age, and gel from 7 years of age. The recommendations here are the same as for adult patients. Children from 2 to 12 years old can take “Nise Kid” tablets or suspensions with the same name orally, while a child under 3 years old can only be given a suspension.

Nise Kid 50 mg dispersible tablets are taken after eating; the tablet should first be dissolved in a teaspoon of water. It is better to drink the suspension before meals.

Children under 12 years old single dose is set at the rate of 3-5 mg of the active component per 1 kg of weight. The medicine is taken 2-3 times a day. Your doctor will help you determine the optimal dose and duration of treatment.

Special instructions

If the drug is used long time, it is necessary to regularly monitor the functioning of the liver and kidneys. After using the gel, you should wash your hands thoroughly with soap.

Avoid contact of the gel with damaged or affected areas of the skin. skin diseases, as well as on mucous membranes and eyes. Airtight dressings should not be used when using the gel.

If it is necessary to use medication during lactation breast-feeding worth pausing.

Question about controllability vehicle or other potentially dangerous mechanism is decided taking into account the patient’s tolerability of the drug.

Drug interactions

It should be noted that the use of Nise simultaneously with:

Warfarin, Acetylsalicylic acid, nonsteroidal and steroidal anti-inflammatory drugs increases the likelihood of bleeding (most often gastrointestinal);
with other non-steroidal anti-inflammatory drugs leads to an increase in the concentration of lithium in the blood plasma with possible manifestation toxic effects;
with Furosemide reduces the effectiveness of the latter;
with Methotrexate increases its concentration and enhances its toxic properties;
with cyclosporines increases the likelihood toxic damage kidney

In this situation, you may have to stop taking one of the medications or change its dosage.

Analogs

Similar medicinal properties have:

Diclofenac;
Ketonal;
Actasulide;
Dexalgin;
Nurofen;
Voltaren;
Dolgit.

It is recommended to first consult with a specialist about the possibility of replacing Nise with analogues.

Drug price

A package of regular tablets of 100 mg (20 pieces) and Nise Kid tablets of 50 mg (20 pieces) can be purchased for 205 rubles, a tube with 20 g of gel - for 195 rubles, a pack of granules for preparing suspension No. 9 (100 mg , 2 g) - for 260 rubles.

Nise cream-gel is a medicinal anti-inflammatory drug intended for external use. It helps eliminate local inflammatory processes, preventing the spread of inflammation, eliminate swelling and pain. This remedy is effective for many diseases and has wide list indications for use. The cream contains a complex of active substances that safely act on skin tissue and do not cause systemic effects.

Interesting! There are several dosage forms drug Nise. Along with the gel-like preparation for external use, tablets and a suspension for oral administration. The tablet form of the drug is available in two forms: solid form for oral administration, as well as water-soluble tablets. All dosage forms have a similar effect, helping to neutralize inflammatory processes. In addition, tablets and suspension have an antipyretic effect, so they are prescribed for elevated temperature bodies.

Indications for use

Cream-gel Nise – anti-inflammatory pharmacological drug, helping to eliminate local inflammatory processes localized in muscles and joints. Doctors prescribe this remedy for the treatment of degenerative and inflammatory processes of the musculoskeletal system, as well as for recovery muscle tissue after injuries and sprains.

Nise cream-gel is prescribed for the treatment of the following diseases:

exacerbation of gout and articular syndrome;
arthritis of rheumatoid and psoriatic type;
spondylitis;
osteoarthritis and osteochondrosis;
radiculitis;
stretching and inflammatory processes of tendons and ligaments;
sciatica;
lumbago;
pain in muscles and joints;
neuralgia and neuritis;
inflammation of soft tissues after injuries and bruises.

individual intolerance to the components included in the composition;
bleeding and erosive and ulcerative diseases of the gastrointestinal tract;
skin diseases accompanied by infection;
violation of the integrity of the epidermis and dermatosis;
renal and liver failure;
pregnancy and breastfeeding;
children under 7 years old.

This drug is prescribed with extreme caution for heart failure, increased blood pressure, diabetes mellitus, children and the elderly. In this case, the drug is used strictly under the supervision of a doctor.

Important! In rare cases, Nise cream gel can cause a number of side effects, which appear local reactions in the form of a rash, itching, peeling of the skin, as well as general reactions body (nausea, dizziness, headache).

Compound

The composition of Nise cream-gel is represented by a complex of substances consisting of an active anti-inflammatory component and a number of auxiliary components.

Active substance this drug is such a component as nimesulide. This is a non-steroidal anti-inflammatory pharmacological substance, which is a sulfonanilide derivative.

The main action performed by nimesulide is the elimination of the inflammatory process by activating the synthesis of prostaglandins. It is prostaglandins that are responsible for relieving inflammation and pain in the affected area.

In addition, this substance affects other mechanisms occurring in the human body, which allows the drug to be used for rheumatoid diseases.

Additionally, nimesulide has an analgesic effect, helping to eliminate discomfort and heaviness in the muscles and limbs. Analgesic effect of this substance quite high, and its analgesic effect begins to appear 15 minutes after applying the cream.

Nimesulide has good penetrating ability, so after just a few hours its maximum concentration is determined in the bloodstream. In addition, this component perfectly enters the site of inflammation, penetrates synovial fluid and tissues of the female genital organs. The substances contained in the gel, along with nimesulide, perfectly penetrate into the joint cavity, providing an active analgesic and anti-inflammatory effect.

What is the price? The price of Nise cream-gel is 300 rubles per 20 gram tube. In the gel form of the drug Nise, the active substance is contained in a concentration of 1%. In addition, the manufacturer produces large packaging of this drug with a volume of 50 grams.

Conclusion

Nise cream-gel is an active anti-inflammatory and analgesic agent that helps neutralize the source of inflammation and prevent its spread. The gel penetrates quickly skin barrier, eliminating inflammatory processes occurring in joints and muscles. In addition, the product has a pronounced therapeutic effect helping to heal damaged tissue and speed up their regeneration.

Instructions for use

Instructions for use of Nise cream-gel:

Pre-wash the skin at the site of the inflammatory process and dry it.
Apply a strip of gel approximately 3 cm long to the affected area and spread it in an even, thin layer.
The drug should not be rubbed in; it should be absorbed on its own.
The exact amount of product applied must be determined based on the area of the affected area and the nature of the disease.
Use this remedy up to 3 times a day.
The therapeutic course should be no more than 10 days.
The gel form of the drug Nise is NOT applied under an occlusive dressing; in addition, avoid contact of this substance with the mucous membranes.
Wash your hands thoroughly after applying the product.

Nise is an anti-inflammatory drug that can have antipyretic, antiplatelet and analgesic effects. Prescribed for inflammatory diseases. The drug belongs to the pharmacological group of NSAIDs, the main active ingredient is nimesulide.

Nise is intended for both oral and external use. Available in the form of tablets, lozenges, dispersible tablets, soluble tablets, suspension, granules (for suspension), granules (for solution), gel.

One tablet contains the main active ingredient - nimesulide - in an amount of 100 milligrams (and the dispersible tablet contains 50 milligrams) and excipients such as calcium phosphate, magnesium stearate, corn starch, talc, pineapple flavor, colloidal silicon dioxide, microcrystalline cellulose, calcium carboxymethyl starch .

Five milliliters of suspension contain the main active ingredient - nimesulide - in an amount of 50 milligrams and excipients such as purified water, sorbitol, pineapple flavor, glycerol, methylparaben, sucrose, polysorbate 80, propylparaben, citric acid, gum, yellow quinoline dye W.S. . The suspension has a characteristic taste and pleasant odor, yellow color.

One percent gel, contains the following excipients: water, thimserosal, propylene glycol, flavoring, isopropanol, potassium phosphate, butylated hydroxyanisole, N -methyl-2-pyrrolidone, carbomer-940, PEG-400.

Indications for use Nise

Nise is recommended for use for the following diseases: tendinitis, bursitis, pain syndrome, radiculitis, Bheterov's disease, febrile syndrome, myalgia, algomenorrhea, neuralgia, inflammation of soft and bone tissues due to trauma, arthritis, osteochondrosis (mainly with radicular syndrome), articular syndrome (for example, with gout), lumbago, sciatica, osteoarthritis, inflammation ligaments and tendons.

Contraindications to the use of Nise

Nise is contraindicated in patients suffering from hypersensitivity to the components of this drug, peptic ulcers stomach or intestines, liver and renal failure, stomach or intestinal bleeding, aspirin asthma, heart failure, arterial hypertension, diabetes mellitus second type. It is prohibited to take Nise in the third trimester of pregnancy, during lactation, for patients under 12 years of age (for tablets), for patients under 2 years of age (for suspensions). The gel is contraindicated if it is present on the area of application. open damage, dermatosis and other skin lesions.

Nise Use during pregnancy and children

Contraindicated during pregnancy and breastfeeding.

Drug interactions

Caution should be exercised when using nimesulide simultaneously with the following drugs(due to competition between drugs for binding to plasma proteins): digoxin, phenytoin and lithium drugs, diuretics and antihypertensive drugs, other NSAIDs, cyclosporine, methotrexate and antidiabetic agents, anticoagulants (dispersible tablets). Pills. The effect of medications that reduce blood clotting is enhanced when used simultaneously with nimesulide. Nimesulide may reduce the effect of furosemide; increase development side effects at simultaneous administration methotrexate. Plasma lithium levels increase when lithium and nimesulide are taken simultaneously. Use with GCS and SSRIs increases the risk of gastrointestinal bleeding.

Nise dosage

Nise is taken internally or externally. Tablets, suspension, granules for suspension and solution are intended for oral use. The gel is intended for external use.

It is recommended to take the tablets before meals, however, if after taking the tablets were recorded discomfort in the stomach, it is permissible to take the drug after meals. Patients over 12 years of age are prescribed from 200 to 400 milligrams per day (2-4 tablets), one tablet per dose.

Dispersible tablets are pre-dissolved in water (a teaspoon of water is required per tablet). For patients aged 3 to 12 years, the required dose of the drug is calculated based on body weight. Patients over 12 years of age are prescribed 100 milligrams (2 tablets) per dose, twice a day.

The suspension can be taken by patients over 2 years of age; for them, the dose of the drug is calculated based on body weight, as well as for all adolescents whose body weight does not exceed 40 kilograms. For patients whose body weight exceeds 40 kilograms, daily dose is 200-400 milligrams of active substance (20-40 milliliters of suspension).

The gel is applied directly to painful area, the skin of which has been thoroughly washed and dried. The gel is applied to the most painful area in a column three centimeters long, after which it is carefully distributed over the painful area in a thin layer (without rubbing). The procedure is carried out 3-4 times a day.

The maximum course of use of the drug Nise is 10 days; it is not recommended to exceed the time of taking Nise.