Sinusitis

Lyoton: instructions for use of the gel and its analogues. Lyoton gel: detailed instructions and recommendations for use, composition, review of analogues and reviews Lyoton is a hormonal drug or not

In the article we will look at the instructions and analogues for the Lyoton gel.

It is a medical preparation with an antithrombotic effect and is intended for topical use. It has an antiexudative and moderate anti-inflammatory effect.

Compound

According to the instructions for "Lioton", active component It contains sodium heparin. Its dosage in each gram of the drug is 1000 IU.

In addition to the main component, auxiliary ingredients such as purified water, ethanol, triethanolamine, carbomer 940, essential oils neroli and lavender, propyl p-hydroxybenzoate, methyl p-hydroxybenzoate.

Pharmacological forms

The only dosage form of "Lioton" is a gel intended for external use. The gel is a slightly yellowish, colorless or almost transparent viscous mass.

The gel is packaged in aluminum tubes, each of which can hold 30, 50, 100 grams of the substance.

Pharmacokinetics and pharmacodynamics

As the instructions for the Lyoton gel indicate, when it comes into contact with the skin, it allows you to relieve swelling, reduce the permeability of the walls of blood vessels, prevent the release of exudate (liquid) into nearby tissues, stop the process of inflammation, and suspend the activity of the blood coagulation system.

After using Lyoton, heparin enters the blood plasma and is stored for 24 hours. Concentration in plasma reaches a maximum 8 hours after application.

Heparin and its metabolites are removed from the body primarily by the kidneys. Heparin, when applied to the skin, does not affect hemocoagulation parameters.

Indications for use

In accordance with the instructions, "Lioton" is indicated for use in patients who have diseases of the superficial veins, complicated, including:

Phlebothrombosis (a pathology in which a thrombus forms in the lumen of a vein, attached to its wall and which completely or partially obstructs the vessel).
Thrombophlebitis, i.e. thrombosis, which is accompanied by inflammation of the vessel wall and blocking of its lumen by a thrombus.
Superficial periphlebitis, which is a chronic inflammation of the venous wall.

The use of "Lioton" can be considered advisable in order to eliminate complications that arose as a result of surgical intervention on the veins, sprains and injuries of the musculotendinous and capsular-ligamentous apparatus, damage musculoskeletal system and soft tissues.

The drug very effectively eliminates localized tissue swelling, inflammatory infiltrates, and allows for accelerated healing of subcutaneous hematomas.

This is confirmed by the instructions for Lyoton 1000.

Contraindications for use

There are several contraindications, in the presence of which experts do not recommend using Lyoton. Among them:

Individual sensitivity to any component included in the gel.
Necrotic as well as ulcerative changes in the skin in those areas where the drug is supposed to be applied.
Traumatic violations of the integrity of the skin.
Reduced hemocoagulation.
Thrombocytopenia.

The instructions for the Lyoton 1000 gel are very detailed.

Side effects

List of probable unwanted effects problems arising from the use of the gel are not so extensive. When using the gel, only allergic skin reactions may occur.

Use, dosage and treatment regimens

In accordance with the instructions for using the medicine, a single dose of Lyoton for an adult is considered to be a column 3-10 cm long. The amount of Lyoton recommended for use depends on the extent of the lesion. After application to the skin, the ointment should be rubbed in with light, gentle movements.

Overdose

The instructions for Lyoton state that there are no registered cases of overdose of this medication. It is believed that the likelihood of an overdose when the gel is applied externally is extremely low. This is due to the fact that systemic absorption of the active component with this type of use is insignificant.

If the gel was accidentally swallowed by a child, he may experience nausea and vomiting. In this case, it is important to perform gastric lavage and prescribe symptomatic therapy, if such a need exists.

The main antidote for sodium heparin is protamine sulfate.

Interaction with other medications

What else can you learn from the instructions for use of Lyoton ointment? With the concurrent use of heparin and oral anticoagulants, there is a possibility of an increase in prothrombin time.

Mixing Lyoton and other external preparations is prohibited.

Concurrent use with antihistamines, tetracycline antibiotics and NSAIDs is contraindicated.

As the instructions for the Lyoton ointment indicate, among the auxiliary components there are propyl p-hydroxybenzoate and methyl p-hydroxybenzoate. In this regard, you should not use the specified medical product patients with a diagnosed allergic reaction to parabens.

Patients with hemorrhagic symptoms It is important to carefully evaluate the feasibility of using Lyoton.

The use of the drug is prohibited if the patient has bleeding and purulent skin lesions. Do not apply Lyoton to the skin around the eyes, any mucous membranes, open wounds and infected skin. It is important to avoid getting the product into your eyes.

If the patient has a hemocoagulation disorder, it is recommended not to use the drug on large areas of the skin. If Lyoton is used for the treatment of phlebitis, rubbing the gel into the skin is contraindicated.

Doesn't exist today sufficient quantity data on the use of Lyoton in children, and therefore the use of the gel in this category of patients is not recommended.

Effects on management ability vehicles the medication does not cause, does not slow down motor and mental activity.

This is confirmed by the instructions.

Analogues of "Lioton"

The following medications are structural analogues, that is, generics: “Heparin”, “Trombless”, “Laventum”, “Heparin-Acrigel”.

The following have a similar mechanism of action medical supplies: “Troxevasin Neo”, “Trombless Plus”, “Venabos”, “Kontraktubeks”, “Dolobene”, “Hepatrombin”, “Heparoid Zentiva”, “Heparin ointment”, “Venolife”, “Venitan forte”.

The most popular analogues Russian production are: “Heparin ointment”, “Heparin-Acrigel”, “Heparin”.

The average cost of analogues starts from 35 rubles. For about the same price you can buy Russian “Heparin ointment” in a 25 gram tube.

"Lioton" and his cheap analogue"Heparin ointment" are direct anticoagulants. Their main effect - antithrombotic - is based on the suppression of thrombin. The main active component of Lyoton is sodium heparin, which is contained in a much lower concentration in Heparin Ointment (about 10 times). However, “Heparin Ointment,” along with sodium heparin, contains the antiplatelet agent benzyl nicotinate and benzocaine, which is a local anesthetic with a wide spectrum of effects. When assessing the effectiveness of these two drugs, patients report approximately the same impact, and therefore decisive factor when choosing a product, its cost is important - “Heparin ointment” costs an order of magnitude cheaper than “Lioton”. The instructions do not contain such information.

Use during pregnancy

Experts admit the possibility of using the gel during pregnancy and lactation, but there must be significant indications for this.

Most often, when prescribing Lyoton to pregnant women, a certain treatment regimen is used - the gel should be used in a course lasting 1 month, then you need to take a month break and repeat the course of use. And so on throughout pregnancy, and sometimes after it.

It is important to carry out the first application of the drug with caution, since a woman’s body during pregnancy is more susceptible to a variety of allergens, and therefore the risk of developing an allergic reaction sharply increases.

If such unpleasant symptoms as burning, itching and redness appear, the woman should stop using Lyoton and consult a doctor.

P N012107/01 dated 07/14/2006

Trade patent name: Lyoton ® 1000

International generic name(INN): heparin sodium

Dosage form:

gel for external use 1000 IU/g

Compound:

1 g of gel contains:
Active ingredient: heparin sodium salt 1000IU
Excipients: methyl parahydroxybenzoate, propyl parahydroxybenzoate, carbomer 940, ethyl alcohol 96%, neroli oil, lavender oil, triethanolamine, purified water.

Description:
Colorless or with a slightly yellowish tint, almost transparent gel of viscous consistency.

Pharmacotherapeutic group:

direct anticoagulant for local use.

ATH CODE: S05BA03

Pharmacological properties
It has a moderate anti-inflammatory and anti-edematous effect, prevents the formation of blood clots (forms a complex with antithrombin III and disrupts the transition of prothrombin to thrombin, inhibits the activity of thrombin, reduces platelet aggregation), weakens the activity of hyaluronidase, increases the fibrinolytic properties of the blood, and has a hypolipidemic effect.

Pharmacokinetics
The maximum concentration in the blood is reached 8 hours after application and returns to normal level in 12-24 hours. It is excreted mainly in the urine.

Indications for use

Thrombophlebitis of superficial veins;
localized infiltrates and swelling of soft tissues;
injuries to tendons and joints, bruises of soft tissues and joints;
subcutaneous hematomas.

Contraindications
Famous increased sensitivity to the components of the gel, ulcerative-necrotic changes in the skin in the areas where the gel is supposed to be applied, traumatic disorder integrity of the skin, decreased blood clotting, thrombocytopenia.

Directions for use and doses
Externally, the gel is applied in a thin layer to the affected area at the rate of 3-5 cm of gel per area of skin with a diameter of 3-5 cm and the ointment is carefully rubbed into the skin 1-3 times a day.
The duration of use is on average from 3 to 7 days (until the inflammatory phenomena disappear).
The duration of treatment is determined by the doctor.

Side effects
Skin allergic reactions, skin hyperemia.

Overdose
Overdose is unlikely due to the low absorption of the gel components.

Interaction with other drugs
It is not recommended to mix with other agents for external use; do not prescribe topically at the same time as non-steroidal anti-inflammatory drugs, tetracyclines, or antihistamines.

Release form
Gel for external use 1000 IU/g.
30, 50 or 100 g of the drug in tubes made of soft aluminum, coated on the inside with epoxy resin with a screw-on perforator cap (polyethylene/polypropylene).
1 tube along with instructions for use is placed in a cardboard box.

Best before date
5 years.
Do not use after expiration date.

Storage conditions
At a temperature not higher than 25 °C.
Keep out of the reach of children.

Release from pharmacies
Over the counter.

Manufacturer:
A. Menarini Industrie Pharmaceutical Riunite S.r.L. produced by A. Menarini Manufacturing Logistics and Services S.r.L., Italy
Distributor company: Berlin-Chemie/Menarini Pharma GmbH, Germany

Berlin-Chemie AG

Tempelhofer Veg 83

12347 Berlin, Germany

Address for filing claims:

123317 Moscow, Presnenskaya embankment, 10, BC "Tower on Naberezhnaya", Block B

Lyoton gel is a proven remedy for varicose veins, and it also helps prevent blood clots and remove bruises.

Since the product contains heparin, it perfectly eliminates inflammation and pain, thins the blood and prevents the formation of clots.

The drug gel Lyoton 1000 helps relieve swelling, reduces vascular permeability and relieves inflammatory process. When applied to the skin, after 8 hours the content of active components in the blood reaches a maximum. Fully therapeutic effect decreases only after 24 hours, and the excretion and breakdown of heparin is controlled by the kidneys.

Conditions for dispensing from pharmacies

Available without a prescription.

Prices

How much does Lyoton 1000 cost? Average price in pharmacies it is at the level of 350 rubles.

Release form and composition

The dosage form of Lyoton is presented as a gel for external use. It is produced in tubes:

30 grams;
50 grams;
100 grams.

One gram contains 1000 IU of sodium heparin and auxiliary agents:

Carbomer 940;
96% ethanol;
Methyl parahydroxybenzoate;
Propyl parahydroxybenzoate;
Triethanolamine;
Lavender and neroli oil;
Water.

Lyoton production belongs to A.Menarini Manufacturing Logistics and Services, Italy.

Pharmacological effect

The drug is used in the treatment of venous and arterial thrombosis. Gel Lyoton 1000 actively affects blood clotting and destroys fibrin, which is the basis of blood clots, thus preventing the formation of blood clots and hematomas. This occurs due to the presence of anticoagulants in the composition (heparin), which also prevents the growth of existing blood clots.

In addition, the effect of the gel is also aimed at reducing the vulnerability of blood vessels, it prevents the formation of soft tissue edema by improving its metabolism and acts as an anti-inflammatory agent. Lyoton 1000 improves blood circulation in tissues and the body.

Indications for use

According to the instructions, Lyoton is indicated in the following cases:

Phlebothrombosis, thrombophlebitis of superficial veins;
Edema and localized infiltrates;
Superficial mastitis;
Varicose veins in the legs;
Various complications after vein operations;
Subcutaneous hematomas;
Bruises and injuries muscle tissue, tendons or joints;
Hemorrhoids, including postpartum.

Also, Lyoton, according to reviews, is effective as a prophylaxis for thrombophlebitis of superficial veins in the treatment of post-infusion and post-injection phlebitis.

Contraindications

Lyoton 1000 is contraindicated for use in the presence of hypersensitivity to the components of the drug.

In case of increased bleeding, the drug should be used with caution.

Use during pregnancy and lactation

Dosage and method of administration

The instructions for use indicate that Lyoton 1000 is used externally, applying the gel to the affected area and gently rubbing, 1-3 times a day. Single dose – 3-10 cm of gel.

Side effects

During the use of Lyoton 1000, development of side effects, manifested in the form allergic reactions.

Overdose

No information available.

Special instructions

Before you start using the drug, read the special instructions:

IM administration of heparin is not recommended due to the possibility of hematoma development, as well as IM administration of other drugs during heparin treatment.

Drug interactions

Reviews

We have selected some reviews from people who have used Lyoton 1000 gel:

Alexander. I've been using it for a week, it helps a lot. They discovered varicose veins and thrombosis on one leg, my calves hurt badly, I started applying it, and after 2 days all the pain went away. I thought it wasn’t because of Lyoton, and didn’t use it for one day, but that was not the case, the pain returned. Nothing hurts when using Lyoton.
Dmitry. I am pleased to leave a review about Lyoton. The gel perfectly relieves swelling, fights the symptoms of varicose veins, and treats bruises. In our family, everyone uses the ointment except the child. None of the relatives have ever had allergies or other side effects. The medicine is used economically; we buy it at the pharmacy once every 2 months.
Victoria. I was prescribed Lyoton for incipient varicose veins, in combination with compression stockings. In general, the impressions of the gel are good, it’s quite pleasant to use, it smells normal, light structure, does not stain clothes. And my legs feel much better after it, fatigue and swelling go away, even, it seems to me, spider veins decreased.
Marina. I really like the smell of Lyoton - it smells very nice of lavender)))) The doctor prescribed me to smear spider veins on your feet. I just bought it - I’ve only been using it for three days, I can’t say anything about the effectiveness, but it’s a fact that very pleasant sensations arise when applied.

Analogs

Gel Lyoton is a highly effective product thanks to active substance heparin. On pharmaceutical market a number of cheaper analogues of the drug are presented. Before replacing Lyoton with another product, you should consult your doctor. The most common analogue of Lyoton is Heparin ointment.

Other similar medications include:

Hepatrombin;
Viatromb;
Heparin;
Troxevasin;
Trombless;
Trombles.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store at a temperature not exceeding 25 °C. Keep away from children. Shelf life – 5 years.

Compound

The composition of Lyoton as an active substance includes heparin sodium at a concentration of 1000 IU/gram.

The auxiliary components of the gel include: methyl and propyl p-hydroxybenzoate, neroli and lavender oils, carbomer 940, triethanolamine, ethanol, purified water.

Release form

The dosage form of the drug is a gel for external use. The product is an almost transparent, colorless or slightly yellowish, viscous mass.

Lyoton 1000 gel is sold in aluminum tubes of 30, 50 or 100 grams.

Pharmacological action

Antithrombotic, anti-exuential, moderate anti-inflammatory.

Pharmacodynamics and pharmacokinetics

When applied to the skin, Lyoton gel relieves puffiness and eliminates increased permeability vascular walls and prevents the release of fluid (exudate) into adjacent tissues, stops the inflammatory process, inhibits the activity of the blood coagulation system (has an anticoagulant anticoagulant effect).

After using the drug heparin found in blood plasma over the next 24 hours, while the plasma concentration reaches maximum values in 8 hours.

Excretion of the substance and its metabolites carried out mainly kidneys. When applied to skin heparin does not affect parameters hemocoagulation.

Indications for use

Ointment Lyoton 1000 is recommended for use in diseases superficial veins, including complicated phlebothrombosis(a condition that is associated with the formation in the lumen of the vein fixed to its wall thrombus, partially or completely obstructing the vessel), thrombophlebitis (thrombosis, which is accompanied by inflammation of the vascular wall and blocking of the lumen of the vessel thrombus) or superficial periphlebitis(spicy or chronic inflammation vein walls).

It is considered advisable to use Lyoton ointment to eliminate complications caused by surgery on veins, consequences of injuries and sprains capsular-ligamentous and musculotendinous apparatus, damage soft tissue and musculoskeletal system.

The product effectively removes localized tissue swelling, eliminates inflammatory infiltrate, accelerates the resorption of subcutaneous hematoma.

Contraindications

You should not use Lyoton 1000 cream if:

known individual sensitivity to its components;
availability ulcerative and necrotic changes skin in areas where the product is intended to be applied;
traumatic violations of the integrity of the skin;
reduced hemocoagulation;
thrombocytopenia.

Side effects

Allergic reactions.

Gel Lyoton, instructions for use

The instructions for use of Lyoton indicate that single dose for an adult corresponds to the volume of gel contained in a strip 3 to 10 cm long (depending on the extent of the lesion). After applying the ointment to the skin, rub it in gently with light movements.

Frequency of applications - from 1 to 3 times a day.

According to the instructions for Lyoton 1000, the duration of treatment depends on the indications and severity pathological process.

Overdose

To date, there have been no reports of overdose cases. Since systemic absorption heparin sodium is extremely insignificant, the danger of overdose with local application absent.

If the gel is accidentally swallowed, a child may experience nausea and vomiting. To help the victim, the stomach should be rinsed and, if necessary, symptomatic treatment should be prescribed.

The antidote is protamine sulfate.

Interaction

Application heparin in combination with anticoagulants for oral administration may cause prolongation of prothrombin time.

Lyoton should not be mixed with other drugs for external use.

It is contraindicated to prescribe the drug in combination with NSAIDs, tetracycline antibiotics, antihistamines.

Terms of sale

Over the counter.

Storage conditions

Best before date

The product is considered suitable for use for 5 years after the date of issue.

Special instructions

The gel contains methyl and propyl p-hydroxybenzoate as auxiliary components, therefore Lyoton is contraindicated in persons with known allergies on parabens.

In patients with hemorrhagic symptoms the feasibility of using the product should be carefully considered.

The drug should not be used for bleeding or skin lesions. purulent process, apply to infected areas of the skin and open wounds, mucous membranes, skin around the eyes. It is also necessary to avoid getting the gel in the eyes.

For patients with disorders hemocoagulation It is not recommended to treat large areas of the skin with the drug. During treatment phlebitis, it is contraindicated to rub the ointment into the skin.

Since experience with Lyoton in children is limited, the drug should not be prescribed for the treatment of this category of patients.

The drug does not affect the ability to drive vehicles and does not slow down mental and motor activity.

Analogs Lyoton 1000

Level 4 ATX code matches:

Structural analogues of Lyoton 1000 gel (generics) are drugs Heparin-Acrigel 1000, Laventum, Trombless, Heparin.

The group of drugs with similar mechanisms of action include: Venitan Forte, Venolife, Heparin ointment, Heparoid Zentiva, Hepatrombin, Dolobene, Contractubex, Venabos, Trombless Plus, Troxevasin Neo.

Russian analogues of Lyoton: Heparin, Heparin-Acrigel, Heparin ointment.

Price of analogues - from 35 Russian rubles(purchase of a tube of Heparin ointment 25 g produced Russian company JSC "Biosintez" will cost approximately 35-60 rubles).

Lyoton or Heparin ointment?

Gel and its analogue Heparin ointment- these are straight anticoagulants. Their main mechanism antithrombotic action associated with suppression thrombin.

Sodium salt heparin, which is the active component of Lyoton, in the composition Heparin ointment is present in a lower concentration - 100 IU/gram (in Lyoton its concentration in one gram of the product is 1000 IU). However, in addition to heparin sodium V Heparin ointment also contains benzocaine (local anesthetic wide range actions) and antiplatelet agent benzyl nicotinate.

Assessing the effectiveness of both drugs, patients note that the effect of their use is expressed approximately equally, therefore, for many, when choosing a drug, the price becomes the deciding factor - Heparin ointment much cheaper than its counterpart.

Lyoton during pregnancy

Gel Lyoton during pregnancy and during the period breastfeeding(lactation) is allowed to be used only for strict indications.

Typically, pregnant women are prescribed to use the drug throughout the entire period of pregnancy (and sometimes after the birth of the child) in courses according to the scheme: a month of use, a month of break.

Caution should be exercised when first applying the product, as during pregnancy the body becomes more susceptible to allergens, and the probability of occurrence allergic reactions increases.

Therefore, if treatment is accompanied by such unpleasant symptoms such as itching, redness of the skin, burning, etc., you should stop using the drug and consult a doctor.

As for reviews of the use of Lyoton by pregnant women, they are very diverse. Some did not see results even after several months of treatment, while others, on the contrary, noted high efficiency medicines.

Reviews about Lyoton 1000

Reviews about Lyoton 1000 gel are mostly positive, as can be judged by the fairly high rating of the product on specialized Internet resources - 4-4.5 points out of 5.

Thanks to high concentration heparin ointment prevents the appearance spider veins, relieves heaviness in the legs, eliminates swelling and pain, is effective for bruises and sprains. Many women see the drug as practically the only salvation for tired legs after a whole day on their feet (and often in high heels).

Very often the drug is prescribed to pregnant women, since during pregnancy the likelihood of problems associated with pregnancy increases significantly. venous insufficiency.

During pregnancy - reviews are eloquent confirmation of this - Lyoton effectively fights stagnation venous blood, prevents the occurrence thrombophlebitis And severe swelling, improves the tone of vascular walls, relieves fatigue.

Negative reviews about the gel are due to the fact that after quite a long time of using this drug, patients were unable to cure varicose veins or notice obvious improvements in the condition of your legs.

Commenting on such statements, experts never tire of repeating that Lyoton does not cure varicose veins, but is only a supporting agent, the use of which allows to slow down the progression of the pathological process and prevent the development of its complications.

For the effect of using the cream to be noticeable, treatment should be supplemented with wearing compression hosiery, contrast shower for legs, swimming, hiking.

It is equally important to stop crossing your legs, instill in yourself the habit of regularly resting your feet (at least try to keep them in an elevated position more often), and give preference to comfortable shoes.

You can also often find them on the Internet positive reviews about Lyoton when used on the face. Despite the fact that the main indication for use is venous diseases, the range of use of the drug is much wider.

For the face, the gel is indicated as a decongestant, firming, toning and refreshing agent. Some women even use it as a base for makeup, and plastic surgeons and cosmetologists often recommend ointment to normalize the condition of facial skin after a series of beauty procedures or, for example, blepharoplasty.

Price of gel Lyoton 1000

Price Lyoton 1000 in Ukraine

Price of Lyoton gel in Kharkov, Kyiv and others major cities Ukraine differs slightly.

The price of the ointment produced in 30 g tubes is from 90 UAH. You can buy a 50 g tube of cream for an average of 160 UAH.

How much does the gel cost in Russian pharmacies?

The cost of the drug depends on the volume of the tube. Buying a 30 g tube will cost approximately 350 rubles. The average price of Lyoton in 50 g tubes is 450 rubles, in 100 g tubes - 700 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

WER.RU

Lyoton 1000 gel 1000 units/g 50 gBerlin-Chemie/A. Menarini

Lyoton 1000 gel 1000 units/g 100 gBerlin-Chemie/A. Menarini

Lyoton 1000 gel 1000 units/g 30 gBerlin-Chemie/A. Menarini

ZdravZona

Lyoton 1000 100g gelA.Menarini Manufacturing Logistics

Lyoton 1000 50g gelA.Menarini Manufacturing Logistics

Lyoton 1000 30g gelA.Menarini Manufacturing Logistics

Pharmacy IFC

Lyoton 1000Berlin-Chemie/ Menarini Group, Italy

Pharmacy24

Lyoton 1000Menarirni Manufacturing (Italy)

Lyoton gel 30gBerlin-Chemie (Germany)

PaniPharmacy

Lyoton gel 30gBerlin-Chemie

BIOSPHERE

Lyoton 1000 100 g external gel A. Menarini Manufacturing Logistics and Services S.r.L. for Astellas Pharma Inc., Japan (Italy)

Lyoton 100000 units/100 g 50 g external gel. (Promotion 2+1)A. Menarini (Italy)

Lyoton 100000 units/100 g 50 g external gel.A. Menarini (Italy)

Lyoton 100000 units/100 g 30 g external gel.A. Menarini (Italy)

PLEASE NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before use medicinal product Lyoton, be sure to consult with your doctor.

Pharmacological action

Anticoagulant direct action, belongs to the group of medium molecular heparins. In blood plasma, it activates antithrombin III, accelerating its anticoagulant effect. It disrupts the transition of prothrombin to thrombin, inhibits the activity of thrombin and activated factor X, and to some extent reduces platelet aggregation.

For unfractionated standard heparin, the ratio of antiplatelet activity (antifactor Xa) to anticoagulant activity (APTT) is 1:1.

Increases renal blood flow; increases cerebral vascular resistance, reduces the activity of cerebral hyaluronidase, activates lipoprotein lipase and has a hypolipidemic effect. Reduces the activity of surfactant in the lungs, suppresses excessive synthesis of aldosterone in the adrenal cortex, binds adrenaline, modulates the ovarian response to hormonal stimuli, and increases the activity of parathyroid hormone. As a result of interaction with enzymes, it can increase the activity of brain tyrosine hydroxylase, pepsinogen, DNA polymerase and reduce the activity of myosin ATPase, pyruvate kinase, RNA polymerase, pepsin.

There is evidence that heparin has immunosuppressive activity.

In patients with coronary artery disease (in combination with ASA) it reduces the risk of developing acute thrombosis coronary arteries, myocardial infarction and sudden death. Reduces the frequency of recurrent infarctions and mortality in patients who have had myocardial infarction. IN high doses effective against thromboembolism pulmonary artery And venous thrombosis, in small cases - for the prevention of venous thromboembolism, incl. after surgical operations.

With intravenous administration, blood coagulation slows down almost immediately, with intramuscular injection - after 15-30 minutes, with subcutaneous administration - after 20-60 minutes, after inhalation the maximum effect is within a day; the duration of the anticoagulant effect is respectively 4-5, 6, 8 hours and 1-2 weeks, the therapeutic effect - prevention of thrombus formation - lasts much longer. Deficiency of antithrombin III in plasma or at the site of thrombosis may reduce the antithrombotic effect of heparin.

When used externally, it has a local antithrombotic, antiexudative, and moderate anti-inflammatory effect. Blocks the formation of thrombin, inhibits the activity of hyaluronidase, and activates the fibrinolytic properties of the blood. Heparin penetrating through the skin reduces the inflammatory process and has an antithrombotic effect, improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and blood clots and reducing tissue swelling.

Pharmacokinetics

After subcutaneous administration, the Cmax of the active substance in plasma is observed after 3-4 hours. Heparin penetrates poorly through the placenta due to its high molecular weight. Not excreted in breast milk.

T1/2 from plasma is 30-60 minutes.

Indications

Prevention and therapy: deep vein thrombosis, pulmonary embolism (including in diseases of peripheral veins), coronary artery thrombosis, thrombophlebitis, unstable angina, acute heart attack myocardium, atrial fibrillation(including accompanied by embolism), disseminated intravascular coagulation syndrome, prevention and therapy of microthrombosis and microcirculation disorders, renal vein thrombosis, hemolyticouremic syndrome, mitral valve disease heart (prevention of thrombosis), bacterial endocarditis, glomerulonephritis, lupus nephritis.

Prevention of blood clotting during operations using extracorporeal circulatory methods, during hemodialysis, hemosorption, peritoneal dialysis, cytapheresis, forced diuresis, when flushing venous catheters.

Preparation of non-clotting blood samples for laboratory purposes and blood transfusions.

Contraindications

Bleeding, diseases accompanied by impaired blood clotting processes, suspicion of intracranial hemorrhage, cerebral aneurysm, hemorrhagic stroke, dissecting aortic aneurysm, antiphospholipid syndrome, malignant arterial hypertension, subacute bacterial endocarditis, erosive and ulcerative lesions Gastrointestinal tract, severe damage to the liver parenchyma, liver cirrhosis with varicose veins veins of the esophagus, malignant neoplasms in the liver, shock conditions, recent surgical interventions on the eyes, brain, prostate gland, liver and biliary tract, condition after puncture spinal cord, menstruation, threatened miscarriage, childbirth (including recent), increased sensitivity to heparin.

Do not apply to open wounds, mucous membranes, and do not use in ulcerative-necrotic processes.

Dosage

Individual, depending on the application dosage form, indications, clinical situation and age of the patient.

Side effects

possible gastrointestinal bleeding and urinary tract, bleeding at the injection site, in areas exposed to pressure, from surgical wounds, as well as hemorrhages in other organs, hematuria, thrombocytopenia.

From the outside digestive system: nausea, loss of appetite, vomiting, diarrhea, increased activity of liver transaminases.

Allergic reactions: skin hyperemia, drug fever, urticaria, rhinitis, itchy skin and a feeling of heat in the soles, bronchospasm, collapse, anaphylactic shock.

From the blood coagulation system: thrombocytopenia (can be severe up to fatal outcome) with the subsequent development of skin necrosis, arterial thrombosis, accompanied by the development of gangrene, myocardial infarction, and stroke.

From the musculoskeletal system: at long-term use- osteoporosis, spontaneous fractures, soft tissue calcification.

Local reactions: irritation, pain, hyperemia, hematoma and ulceration at the injection site.

Others: transient alopecia, hypoaldosteronism.

Drug interactions

The anticoagulant effect of heparin is enhanced by the simultaneous use of anticoagulants, antiplatelet agents and NSAIDs.

Ergot alkaloids, thyroxine, tetracycline, antihistamines, as well as nicotine reduce the effect of heparin.

Special instructions

Use with caution in patients suffering from polyvalent allergies (including bronchial asthma), at arterial hypertension, dental procedures, diabetes mellitus, endocarditis, pericarditis, in the presence of an intrauterine contraceptive device, with active tuberculosis, radiation therapy, liver failure, chronic renal failure, in elderly patients (over 60 years old, especially women).

Use externally with caution for bleeding and conditions of increased bleeding, thrombocytopenia.

During treatment with heparin, monitoring of blood clotting parameters is necessary.

To dilute heparin, only saline solution is used.

If severe thrombocytopenia develops (a decrease in the platelet count by 2 times the initial number or below 100,000/μl), it is necessary to urgently stop using heparin.

The risk of bleeding can be minimized with careful assessment of contraindications, regular laboratory monitoring of blood clotting, and adequate dosing.

Pregnancy and lactation

Use during pregnancy is possible only according to strict indications, under close medical supervision.

Possible use during lactation (breastfeeding) according to indications.

For impaired renal function

Use with caution in patients with chronic renal failure.

For liver dysfunction

Contraindicated in cases of severe damage to the liver parenchyma, cirrhosis of the liver with varicose veins of the esophagus, malignant neoplasms in the liver, after recent surgical interventions on the liver and bile ducts. Use with caution in case of liver failure.

Use in old age

Use with caution in elderly patients (over 60 years of age, especially women).

The description of the drug LIOTON 1000 is based on the officially approved instructions for use and approved by the manufacturer.

Lyoton – universal remedy, which has an anti-inflammatory effect, prevents the formation of blood clots and effectively fights painful sensations. For feet Lyoton is useful for different forms venous pathologies.

When you plan to purchase Lyoton, instructions for use of the gel according to which it will be used are studied in mandatory to prevent misuse.

Trombless;
Venolife;
Venitan Forte;
Russian analogues: Heparin, Heparin-Acrigel.

It is often customary to choose between Trombless gel or Lyoton or to argue that Dolobene is better. All of these drugs are aimed at suppressing thrombin, so you can choose based on personal preferences and price category.

In terms of the characteristics of the medicinal formula, the drugs are similar. First, you can clarify the opinion of specialist doctors who will help you choose the appropriate drug for each specific case.

After purchasing Lyoton ointment, many people noted it positive effect. But at the same time, considering the differences between heparin and the differences, Heparin ointment has the same effect. The cost of Heparin ointment is different (it is cheaper), so many people prefer to use this Russian analogue.

Each of these two ointments is good and therefore the deciding factor is the price. Both drugs are anticoagulants and their list of effects is the same - preventing the formation of blood clots.

Lyoton gel is a medicine for external use. Viscous mass with an aromatic odor, colorless or slightly yellow. This drug received widespread due to excellent anti-clotting properties.

Pharmacological action

Gel is anticoagulant. The composition is based on heparin (a substance that prevents the formation of blood clots, found in the kidneys in the human body). Once in the blood, it causes blood protein to accelerate its anti-clotting effect.

Prevents accelerated formation of clots. Heparin gradually released from the ointment, entering through the skin, penetrates the organs and blood.

Thanks to it, blood flow in the kidneys increases, vascular resistance increases, and the risk of developing thrombosis and myocardial infarction decreases.

Promotes the resorption of skin growths. Does not affect blood clotting.

Pharmacokinetics

The absorption rate is insignificant. It enters the bloodstream 8 hours after application. The gel substances continue to be observed in the blood for 24 hours after use.

The drug substances are excreted from the body by the kidneys, along with urine. What is very important for pregnant and lactating women, through breast milk doesn't stand out.

Indications for use

Often used as a pain reliever.

Doctors prescribe it for varicose veins, thrombophlebitis (inflammation of the vein wall and the formation of blood clots), the formation of hematomas under the skin (accumulation of blood in the tissues - bruises), swelling, tumors, pain, injuries and bruises (fractures), complications after operations on the veins (formation of seals, no identified infections).

Contraindications for taking the drug

Not for use on mucous membranes(causes irritation), with bleeding and purulent processes.

The drug should not be applied to open wounds, in case of impaired blood clotting, cirrhosis of the liver, menstruation, threat of miscarriage or before childbirth, states of shock, as well as recent operations on the eyes, brain, bile ducts (bleeding is possible).

Mechanism of action

Upon entry into the body (blood, soft fabrics) person through the skin, active substances The drug begins to act approximately eight hours from the moment of application. The action of the gel is aimed at reducing blood clotting, which leads to improved blood flow and prevents the formation of blood clots.

Instructions for use

We invite you to read the detailed instructions for using Lyoton gel.

For bruises and abrasions, doctors advise applying the gel to the skin using circular, soft movements of the fingers. In case of thrombosis, most often, bandages with a gel applied to them are applied.

For open ulcers, the skin around the ulcer itself should be treated. For hemorrhoids, the gel is used on a tampon for insertion into the anus.

Directions for use

The drug is available exclusively in gel form.

The drug is used externally, applied directly to the damaged area, except in cases trophic ulcers or mechanical damage skin.

Dosage depending on concomitant disease

For swelling, injuries and bruises, applied one to three times a day. The course lasts until the bruises and swelling completely disappear.
At initial stage varicose veins(heaviness in the legs, burning along the veins, the appearance of small capillaries on the surface of the skin), the course of use is from one to three weeks.
For chronic venous insufficiency (varicose veins, thrombophlebitis) the drug is recommended to be used from a month to six months.

Release forms

Gel for external use 1000 IU/g.

Lyoton 1000 gel is available in tubes coated inside with epoxy resin, made of soft aluminum, with a screw cap, in dosages of 30, 50, and 100 grams of the drug.

The composition includes cardboard packaging, a tube of gel, and instructions.

Overdose and additional instructions

An overdose is unlikely, since the low absorption of the drug does not allow it to be administered too much. Does not affect the control of vehicles and various mechanisms.

In case of contact with mucous surfaces, rinse with water.

If a child has used the drug orally, it is necessary to immediately induce vomiting and rinse the stomach.

Lyoton is available in pharmacies without a prescription.

Side effects

With prolonged use, redness, itching, and dryness are possible, which are removed with regenerating creams or lotions. This is not an allergy, but the result of long-term use of the gel components.

Special instructions

Key tips include:

stop taking it if you are allergic to any of the components of the drug;
do not use if a disease causing bleeding is detected;
Do not use the gel if you have bleeding disorders;
do not rub into the skin when treating phlebitis.

Interactions with other drugs

This drug is often used in complex therapy varicose diseases.

Therefore, when using drugs that affect blood composition (aspirin, declofenac, etc.), you should consult a doctor, as bleeding is possible.

Use during pregnancy and breastfeeding

The instructions for the drug indicate that it is not excreted in milk, so it can be used during lactation.

Pregnant women are not advised to use the drug if there is a threat of miscarriage and immediately before birth.

In all cases, the use of the drug is possible only as directed by a doctor.

Reviews from patients and doctors

Reviews from doctors about Lyoton gel on medical forums positive.

“The result is obvious from the first days of use, lightness appears in the legs, disappears vascular network. Abrasions and bruises after injuries heal after 5 days of use.

After surgical interventions for the purpose of postoperative prevention, interaction with the most the best remedy. The preparation contains the most great content heparin compared to other products available on the market. It is able to quickly penetrate tissues and organs through the skin and begin to act in them.”