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Mefenamic acid composition. Mefenamic acid is a great assistant in relieving pain.

Mefenamic acid is a non-steroidal anti-inflammatory and anti-rheumatic drug used for diseases of the musculoskeletal system, mild and moderate pain, as well as fever.

pharmachologic effect

Mefenamic acid has anti-inflammatory, antipyretic and analgesic properties.

The anti-inflammatory effect of mefenamic acid is due to its ability to inhibit the synthesis of prostaglandins and serotonin, which take an important part in the processes of inflammation. The ability to reduce the production of prostaglandins and influence the thermoregulation center explains the antipyretic effect of mefenamic acid. The analgesic effect of the drug is due to its influence on the central and peripheral mechanisms of pain sensitivity.

Mefenamic acid can increase the activity of T-lymphocytes, which play a significant role in the functions of the immune system, and stimulate the production of interferon, which suggests its anti-inflammatory effect. After oral administration, the maximum concentration of mefenamic acid in the blood can be observed after 2-4 hours. The half-life of the drug is 3 hours. About 67% of mefenamic acid is excreted in the urine, and the rest in feces.

Indications for use

Mefenamic acid, the instructions confirm, is effective for such inflammatory diseases of the musculoskeletal system as:

  • rheumatism (a disease that affects the cardiovascular system and connective tissue);
  • gout (a disease of the joints caused by the accumulation of uric acid in them);
  • rheumatoid arthritis (destructive damage to large and small joints of the extremities);
  • Ankylosing spondylitis (limited mobility of the spine and possible involvement in the inflammatory process of the lungs, kidneys, heart and other internal organs).

It is advisable to use mefenamic acid to eliminate pain in neuralgia, radiculitis, menstruation, childbirth, and cancer.

Mefenamic acid is also effective for mild or moderate headaches and toothaches, pain in muscles, joints, bones, pain during menstruation, febrile syndrome accompanying infectious and colds.

Instructions for use of mefenamic acid


Mefenamic acid is available in the form of a powder substance and tablets (250 mg or 500 mg). It is recommended to take the drug orally after meals with milk. Adults are usually prescribed 250-500 mg 3-4 times a day, while the maximum daily dose should not exceed 3 grams, the recommended daily dose after achieving a therapeutic effect is 1 gram.

Mefenamic acid for children 5-10 years old is prescribed in a single dose of 250 mg, and for children over 10 years old - 300 mg, the frequency of doses for these age groups is 3-4 times a day.

The instructions recommend taking mefenamic acid for 20-45 days, but if necessary, the course can be extended to 2 months or more.

Locally, mefenamic acid is used in the form of a 1% paste or 0.1-0.2% solution. The paste is recommended to be injected into periodontal pockets after 1-2 days (6-8 sessions), and applications should be made with an aqueous solution 1-2 times a day for ulcerative lesions of the oral mucosa.

Side effects

According to the instructions, mefenamic acid can provoke the manifestation of such undesirable effects as:

  • gastrointestinal discomfort, indigestion, heartburn, nausea, loss of appetite, diarrhea, flatulence, constipation, gastrointestinal bleeding;
  • increased blood pressure, heart rhythm disturbances, peripheral edema;
  • nonspecific inflammation of the kidneys, hematuria (the presence of blood in the urine in an amount exceeding the norm), albuminuria (protein excretion in the urine);
  • bronchospasm, shortness of breath;
  • drowsiness, blurred vision, general weakness, insomnia, nervousness;
  • allergic skin reactions;
  • with high concentrations in the blood - vomiting, convulsions, muscle twitching;
  • with long-term use - impaired hematopoiesis, decreased hematocrit (the ratio of red blood cell volume to blood volume), hemolytic anemia (a disease caused by increased destruction of red blood cells).

Contraindications to the use of mefenamic acid

Mefenamic acid is not prescribed for hypersensitivity, peptic ulcers, inflammatory processes of the digestive tract, blood diseases and impaired renal and liver function.

Mefenamic acid is contraindicated for children under 5 years of age and for pregnant and lactating women.

Additional Information

Mefenamic acid will be suitable for use for 3 years, provided it is stored in a dry and dark place where the air temperature does not exceed 250C.

Sincerely,


Compound

active substance: mefenamic acid

1 capsule contains mefenamic acid 250 mg or 500 mg

Excipients:

250 mg capsules talc lactose monohydrate, corn starch sodium lauryl sulfate; silicon dioxide; magnesium stearate

500 mg capsules talc, stearic acid, corn starch, sodium lauryl sulfate, crospovidone.

Dosage form

Basic physical and chemical properties: hard gelatin capsules of size “0”, with a light blue cap and a light yellow body, or vice versa, the contents of the capsules are white or almost white powder.

Pharmacological group

Non-steroidal anti-inflammatory drugs. Fenamata.

ATX code M01A G01.

Pharmacological properties

Pharmacological.

NSAIDs (NSAIDs). Has anti-inflammatory, analgesic and antipyretic effects. Suppresses the synthesis of inflammatory mediators (prostaglandins, serotonin, kinins), reduces the activity of lysosome proteases involved in the inflammatory response. Affects the phases of exudation and proliferation. Stabilizes protein ultrastructures and cell membranes, reduces vascular permeability and tissue swelling. Inhibits cell proliferation at the site of inflammation; increases cell resistance and stimulates wound healing. The antipyretic effect is due to the inhibition of prostaglandin synthesis and the effect on the thermoregulation center. Stimulates the formation of interferon.

Pharmacokinetics.

After oral administration, it is quickly and almost completely absorbed from the digestive tract. The maximum concentration in the blood is reached after 2-4 hours. The blood level is proportional to the dose. In the vascular bed it binds to albumin. The half-life is 3:00. Forms a number of metabolites in the liver. 67% of the dose taken is excreted unchanged in the urine, 20-25% in feces.

Indications

Acute respiratory viral infections and influenza.

Primary dysmenorrhea. Dysfunctional menorrhagia.

Inflammatory diseases of the musculoskeletal system: rheumatoid arthritis, rheumatism, ankylosing spondylitis.

Pain syndrome of low and medium intensity: muscle, joint, traumatic, dental, headache of various etiologies, postoperative and postpartum pain.

Contraindications

Hypersensitivity to the components of the drug. Bronchospasm, Quincke's edema, rhinitis, bronchial asthma, urticaria in history, which occurred after the use of acetylsalicylic acid or other NSAIDs. Simultaneous administration of specific COX-2 inhibitors. Peptic ulcer of the stomach and duodenum is present or in history, inflammatory bowel diseases, diseases of the hematopoietic organs, severe heart failure, severe liver or kidney dysfunction, gastrointestinal bleeding or perforation caused by taking non-steroidal anti-inflammatory drugs, treatment of pain after coronary artery bypass surgery.

Interaction with other drugs and other types of interactions

Thiamine, pyridoxine hydrochloride, barbiturates, phenothiazine derivatives, narcotic analgesics, caffeine, diphenhydramine increase the analgesic effect of the drug.

Methotrexate: with the simultaneous use of mefenamic acid and methotrexate, there may be a potential increase in the level of methotrexate in the blood plasma and an increase in its toxic effect.

Probenecid: decreased metabolism, delayed removal of probenecid from the body.

Antihypertensives (ACE inhibitors and angiotensin II receptor antagonists): decreased antihypertensive effect, increased risk of renal failure, especially in elderly patients. Patients should drink enough fluids. It is also necessary to assess renal function at the beginning of treatment and during concomitant therapy.

Diuretics: decreased diuretic effect. Diuretics may increase the nephrotoxicity of NSAIDs.

Cardiac glycosides: NSAIDs may worsen heart failure, reduce glomerular filtration rate and increase plasma levels of cardiac glycosides. Cyclosporines: increased risk of developing nephrotoxicity.

Mefipristone: NSAIDs should not be taken within 8-12 days after taking mefipristone; NSAIDs may reduce the effect of mefipristone.

Corticosteroids: increased risk of developing gastrointestinal ulcers and bleeding. Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding.

Fluoroquinolones: NSAIDs increase the risk of seizures.

Aminoglycosides: NSAIDs increase the risk of nephrotoxicity.

Tacrolimus: there may be an increased risk of developing a nephrotoxic effect.

Zidovudine: NSAIDs increase the risk of hematological toxicity. The risk of joint hemorrhage and hematoma increases in HIV-positive hemophiliacs who are simultaneously treated with zidovudine.

Lithium preparations decreased excretion of lithium and increased risk of developing lithium toxicity.

Oral anticoagulants mefenamic acid increases the activity of oral anticoagulants , therefore, their simultaneous use increases the risk of bleeding. It is possible to reduce the dose of the anticoagulant. Concomitant use of mefenamic acid with oral anticoagulants requires careful monitoring of prothrombin time. It is considered dangerous to take NSAIDs with warfarin or heparin; medical examination is necessary.

Concomitant use with other NSAIDs increases the anti-inflammatory effect and the likelihood of side effects from the gastrointestinal tract.

Features of application

Mefenamic acid should be used in patients who have previously experienced hypersensitivity reactions (for example, asthma, bronchospasm, rhinitis, angioedema or urticaria.

Do not use in dehydrated patients who have lost fluid due to vomiting, diarrhea, or increased urination.

For long-term treatment of headaches, you should consult your doctor.

Prescribe with caution to patients with acute cardiovascular failure, arterial hypertension, and coronary heart disease. Mefenamic acid may be associated with a small increase in the risk of heart attack or stroke. Any risk is associated with increasing the dose of the drug or long-term treatment. When treating mefenamic acid, patients with cardiovascular and cerebrovascular diseases should seek medical advice and not increase the recommended dose or duration of treatment.

Prescribe with caution to patients with epilepsy.

When using mefenamic acid, moderate impairment of liver and kidney function may occur. For patients who experience such disorders, the drug should be discontinued. Patients using mefenamic acid for a long time should be monitored due to the possibility of liver and kidney dysfunction.

NSAIDs should be taken with caution in patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease, inflammatory bowel disease), since exacerbation of the disease is possible. If the use of mefenamic acid leads to gastrointestinal bleeding and perforation, treatment should be discontinued.

Elderly patients generally have an increased risk of developing gastrointestinal side effects, especially gastrointestinal bleeding and perforation, which can be fatal, so treatment should begin at dosage itself.

Patients with systemic lupus erythematosus and mixed connective tissue diseases may be at increased risk of aseptic meningitis.

Mefenamic acid should be used with caution in patients at high risk of serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis. At the first manifestations of a skin rash, lesions of the mucous membrane or any signs of hypersensitivity, the drug should be discontinued.

With long-term use of the drug, it is necessary to monitor blood counts, since mefenamic acid can cause pathological changes in the blood. If manifestations of any dyscrasia occur, it is necessary to discontinue drug therapy.

Taking mefenamic acid may cause gastrointestinal problems (eg diarrhea). They can occur either immediately after using the drug or after long-term use. If such symptoms occur, you must stop using the drug.

Caution should be exercised when using mefenamic acid in patients receiving therapy with drugs that may increase the risk of bleeding - corticosteroids, anticoagulants (warfarin) and aspirin.

Taking mefenamic acid may impair female fertility and is not recommended for women who are trying to become pregnant. When used by women with symptoms of dysmenorrhea and menorrhagia and the absence of a therapeutic effect, it is necessary to consult a doctor.

Mefenamic acid, 250 mg capsules, contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.

Use during pregnancy or breastfeeding

The drug should not be used by women during pregnancy.

The drug should not be used by women during breastfeeding.

The ability to influence the reaction rate when driving vehicles or other mechanisms

Caution should be exercised when driving vehicles or working with mechanisms that require increased attention, since sometimes the use of the drug can cause drowsiness, blurred vision, and convulsions.

Directions for use and doses

Use the drug orally after slush.

For adults and children over 12 years of age, prescribe 250-500 mg 3-4 times a day. If necessary, the dose can be increased to 3 g per day. After achieving a therapeutic effect, the daily dose should be reduced to 1 g.

The course of treatment for joint diseases can last from 20 days to 2 months or more. When treating pain syndrome, the course of treatment lasts up to 7 days.

Children

Overdose

Symptoms: epigastric pain, nausea, vomiting, drowsiness, headache, rarely - diarrhea, disorientation, agitation, tinnitus, loss of consciousness, sometimes convulsions (mefenamic acid tends to induce tonic-clonic seizures in overdose). In severe cases - gastrointestinal bleeding, respiratory depression, arterial hypertension, twitching of individual muscle groups, coma. In cases of significant poisoning, renal and liver failure are possible.

Treatment: There is no specific antidote. Gastric lavage with a suspension of activated carbon. Alkalinization of urine, forced diuresis. Symptomatic therapy. Hemosorption and hemodialysis are ineffective due to the strong binding of mefenamic acid to blood proteins. Kidney and liver function should be carefully monitored. Frequent or prolonged seizures should be treated with diazepam.

Adverse reactions

From the gastrointestinal tract: epigastric pain, anorexia, heartburn, nausea, flatulence, vomiting, enterocolitis, colitis, exacerbation of colitis and Crohn's disease, gastritis, hepatotoxicity, steatorrhea, cholestatic jaundice, hepatitis, pancreatitis, hepatorenal syndrome, hemorrhagic gastritis, ulcer with/without bleeding, melena, ulcerative stomatitis. Gastrointestinal bleeding, dyspepsia, constipation, diarrhea; perforation or gastrointestinal bleeding, sometimes fatal, especially in elderly patients. Increased levels of liver enzymes in blood plasma.

From the cardiovascular system: arterial hypertension, arrhythmia, rarely - congestive heart failure, peripheral edema, fainting, arterial hypotension, palpitations, shortness of breath, thrombotic complications (for example, myocardial infarction or stroke).

From the respiratory system: shortness of breath, bronchospasm.

From the urinary system: dysuria, cystitis. Impaired renal function, albuminuria, hematuria, oliguria or polyuria, renal failure, including papillary necrosis, acute interstitial nephritis, nephrotic syndrome, allergic glomerulonephritis, hyponatremia, hyperkalemia.

From the blood side: aplastic anemia, autoimmune hemolytic anemia, increased bleeding time, eosinophilia, leukopenia with risk of infection, sepsis or disseminated intravascular coagulation, thrombocytopenia, decreased hematocrit, thrombocytopenic purpura, agranulocytosis, neutropenia, pancytopenia, bone marrow hypoplasia.

From the nervous system and psyche: drowsiness or insomnia, weakness, irritability, agitation, headache, blurred vision, convulsions, confusion, depression, hallucinations, optic neuritis, paresthesia, dizziness, stiff neck, fever, disorientation.

From the senses: tinnitus, ear pain, otalgia, visual disturbances, reverse color loss, eye irritation.

From the immune system: purpura, hypersensitivity reactions including rash, pruritus, facial swelling, allergic rhinitis, angioedema, laryngeal edema, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, urticaria, bullous pemphigus, photosensitivity, asthma, anaphylactic shock.

Other: impaired glucose tolerance in patients with diabetes mellitus, aseptic meningitis, sweating, increased fatigue, malaise, multiple organ failure, hyperthermia, positive reaction in some tests for the presence of mefenamic acid and metabolites in bile and urine.

Flamingo Pharmaceuticals Ltd.

Mefenamic acid: instructions for use and reviews

Latin name: Mefenamic acid

ATX code: M01AG01

Active substance: mefenamic acid

Manufacturer: Flamingo Pharmaceuticals Ltd., India

Updating the description and photo: 13.08.2019

Mefenamic acid is a drug with analgesic, antipyretic and anti-inflammatory effects.

Release form and composition

Mefenamic acid is produced in the form of tablets (in blister packs of 10 pcs., 1 or 2 packs in a cardboard box).

1 tablet contains:

  • Active substance: Mefenamic acid – 0.5 g;
  • Auxiliary components: octadecanoic acid, potato starch, methylcellulose, croscarmellose sodium, magnesium stearate.

Pharmacological properties

Pharmacodynamics

Mefenamic acid is a derivative of anthranilic acid and belongs to the group of antirheumatic and nonsteroidal anti-inflammatory drugs. The drug is able to reduce the intensity of the body's production of specific inflammatory mediators - prostaglandins and serotonin. Mefenamic acid affects both the central mechanisms of increasing pain sensitivity and processes occurring in the periphery, and also suppresses the activity of lysosome proteases.

Mefenamic acid helps stabilize cell membranes and protein ultrastructures, eliminates swelling and reduces capillary permeability. The antipyretic effect of the active component of the drug is explained by its ability to influence the thermoregulation center located in the brain and suppress the production of inflammatory mediators.

Mefenamic acid is also characterized by a moderate antiviral effect due to stimulation of interferon synthesis and an increase in the concentration of T-lymphocytes and T-helper cells.

Pharmacokinetics

After oral administration of mefenamic acid, its maximum concentration in the blood is reached after approximately 3 hours. The content of the substance in the blood plasma directly depends on the dose taken (there is a linear relationship). Mefenamic acid is highly protein bound and metabolized in the liver. The half-life is 120–240 minutes, and the drug is excreted in urine and feces.

Indications for use

  • Symptomatic treatment of pain syndrome;
  • Influenza and acute respiratory viral infections (simultaneously with other drugs);
  • Feverish conditions (as an antipyretic);
  • Inflammatory disorders of the osteoarticular system: rheumatism, rheumatoid arthritis, ankylosing spondylitis;
  • Pain, inflammation and swelling developing in the post-traumatic and postoperative periods;
  • Blood loss during menorrhagia, which is caused by ovulatory dysfunctional bleeding in the absence of pathologies of the pelvic organs;
  • Functional dysmenorrhea.

Contraindications

  • Functional disorders of the kidneys and liver;
  • Inflammatory diseases of the gastrointestinal tract;
  • Peptic ulcer of the stomach and duodenum;
  • Blood diseases;
  • Age up to 5 years;
  • Pregnancy and lactation (breastfeeding);
  • Hypersensitivity to the components of the drug.

Instructions for use of Mefenamic acid: method and dosage

Mefenamic acid is taken orally after meals.

A single dose is determined by age:

  • Adults and children over 12 years of age: 0.25-0.5 g (maximum daily dose – 3 g, with improvement, reduce the dose to 1 g);
  • Children 5-12 years old: 0.25 g.

The frequency of taking the drug is 3-4 times a day.

The doctor determines the duration of treatment individually (on average 20-60 days). When carrying out symptomatic treatment of pain syndrome, the drug is usually used for up to 7 days.

Side effects

Most often, during the use of Mefenamic acid, gastrointestinal disorders occur, manifested as dyspepsia, gastrointestinal discomfort, epigastric pain, diarrhea, and increased levels of liver enzymes. Taking the drug can lead to the development of stomach ulcers and gastrointestinal bleeding.

The following side effects may also occur during therapy:

  • Cardiovascular system: increased blood pressure, rhythm disturbances, peripheral edema; rarely – congestive heart failure;
  • Central nervous system: very rarely – irritability, sleep disturbance;
  • Genitourinary system: nonspecific inflammation of the kidneys, functional disorders of the kidneys, dysuria, albuminuria, hematuria;
  • Respiratory system: bronchospasm, dyspnea;
  • Hematological effects: eosinophilia, agranulocytosis, thrombocytopenic purpura or thrombocytopenia, hemolytic anemia;
  • Allergic reactions: urticaria, skin rash.

Overdose

Symptoms of an overdose of Mefenamic acid include drowsiness, decreased blood pressure, nausea, vomiting, gastrointestinal bleeding, pain in the abdomen, depression of the respiratory center, convulsions, coma.

The active component of the drug does not have a specific antidote. When taking too high doses of Mefenamic acid, it is recommended to rinse the stomach and take enterosorbents. Acidification of urine and forced diuresis are also indicated. The effectiveness of hemodialysis in this case remains insignificant.

special instructions

According to the instructions, Mefenamic acid should not be taken by patients with allergies to aspirin and non-steroidal anti-inflammatory drugs, severe heart failure, ulcers, intestinal perforation, severe liver cirrhosis, or after heart surgery.

The drug should be taken with caution by elderly patients, as well as by epilepsy, dehydration, allergies, asthma, diabetes, circulatory disorders, risk of stroke, angina pectoris, bleeding disorders, porphyria, decreased liver or kidney function. This group of patients may require a dose reduction or change in therapy regimen.

To reduce irritation of the gastric mucosa, the drug is recommended to be taken with meals. It is also possible to reduce the dose taken if necessary. If skin rashes or diarrhea develop, the drug should be interrupted.

With prolonged treatment, blood counts and kidney and liver function should be monitored.

While using Mefenamic acid, it is not recommended to drive vehicles or perform work that requires high attention and quick psychomotor reactions.

Use in childhood

Mefenamic acid is not prescribed to children under the age of 5 years.

The maximum daily dose of Mefenamic acid for children aged 5 to 12 years is 1 g. Usually prescribed 250 mg 3-4 times a day. The duration of therapy is determined by the doctor.

Drug interactions

When using Mefenamic acid simultaneously with certain medications, undesirable effects may occur:

  • Opioid analgesics, dicoumarin, vitamins B6, B1, phenothiazine derivatives: increased effect of Mefenamic acid;
  • Anticoagulants, vitamin K antagonists: enhancing their effect;
  • Methotrexate: strengthening of its negative effects;
  • Warfarin, non-steroidal anti-inflammatory drugs: increased risk of gastrointestinal disorders;
  • Antacids: increased bioavailability of Mefenamic acid, increased side effects.

Analogs

Analogues of Mefenamic acid are: Mefenamic acid-Darnitsa, Jenospa.

Terms and conditions of storage

Store out of reach of children at temperatures up to 25 °C.

Mefenamic acid is a non-steroidal, anti-inflammatory, antipyretic, antiviral drug.

Compound

In 1 tab. - 500 mg. mefenamic acid.

Auxiliary ingredients: stearic acid, croscarmellose sodium, methylcellulose, magnesium stearate, potato starch.

The tablets are grayish in color with a greenish tint, convex in shape with a score line.

Pharmacological properties

Refers to anti-inflammatory, analgesic, antipyretic drugs. Affects the central and peripheral mechanisms of pain sensitivity, weakens local inflammation.

Stabilizes cell membranes, reduces the permeability of the vascular wall. At the site of inflammation, it reduces cell proliferation and stimulates healing.

Affects the thermoregulation center, which contributes to the antipyretic effect. Increases the activity of T lymphocytes, which play an important role in the function of the immune system, stimulates the production of interferon, which has an anti-inflammatory effect. It is quickly absorbed into the gastrointestinal tract, the effect of the drug occurs after two or three hours. Metabolized in the liver. This drug is excreted mainly in urine, and in a small percentage in feces.

Instructions for use

  • Rheumatoid arthritis;
  • Postoperative pain;
  • Rheumatism;
  • Neuralgia;
  • Myalgia;
  • Gouty arthritis;
  • Headache;
  • Cancer pain;
  • For fever and colds;
  • With a viral infection;
  • Traumatic pain;
  • Periodontal disease.

Dosage

Children from 5 to 12 years old are usually prescribed 250 mg three, possibly four times a day. Duration of treatment is 20 - 60 days.

For adolescents over 12 years of age and adult patients, this drug is prescribed, as a rule, from 250 to 500 mg 3-4 times a day. If there is a need, it is possible to increase the dosage to 3000 mg; if positive results are obtained, the dose should be reduced to 1000 mg. For symptomatic treatment in case of pain, use for up to one week.

Overdose

This drug tends to provoke ulcers, as well as erosion of the gastrointestinal tract, and rarely, tonic-clonic convulsions.

Symptoms: vomiting, stomach pain; very rarely - gastric bleeding, impaired blood pressure, depressed breathing, coma.

Treatment: induce vomiting, take sorbents. Forced diuresis. Treatment is symptomatic. Due to the strong binding of mefenamic acid to albumin, hemodialysis will not be effective.

Side effects

  • The most common (at the beginning of treatment) side effect is disruption of the gastrointestinal tract;
  • peripheral edema;
  • sleep disturbance, increased irritability;
  • dysuric manifestations;
  • discomfort in the gastrointestinal tract;
  • abdominal pain;
  • tachycardia;
  • bronchospasm;
  • blood pressure disorder;
  • kidney dysfunction;
  • skin rash, sometimes urticaria.

Contraindications

  • Blood disease;
  • Individual intolerance to drug components;
  • For peptic ulcer disease;
  • In inflammatory processes of the gastrointestinal tract;
  • Impaired functioning of the kidneys and liver;
  • Pregnancy and breastfeeding period;
  • Children under 5 years old.

Interaction of Mefenamic acid with other drugs.

When mefenomic acid is used together with methatroxate, the toxic properties of methatroxate may increase.

Taking it with warfarin may increase the risk of gastrointestinal bleeding.

special instructions

Mefenamic acid should not be prescribed to patients who have undergone heart surgery, or have severe liver disease (cirrhosis), or intestinal perforation.

With extreme caution, this drug is prescribed to elderly patients suffering from epilepsy, asthma, those with a tendency to allergies, diabetes mellitus, blood clotting disorders, and impaired kidney and liver function. For these patients, the dosage should be adjusted, the dose may be reduced, this is decided by the doctor.

To reduce irritation of the gastric mucosa, take the drug with meals, or perhaps reduce the dose.

If skin rashes or other signs of side effects occur, Mefenamic acid should be discontinued.

During long-term treatment with the drug, it is necessary to constantly monitor the blood count, kidney function, and liver function.

The drug is prescribed with extreme caution to patients who are intolerant to acetylsalicylic acid and other anti-inflammatory drugs.

Patients suffering from cardiac dysfunction, gastric ulcers.

This drug is contraindicated in pregnant women due to the possibility of premature closure of the ductus botallus.

During breastfeeding, if there is a need to take the drug, then breastfeeding should be discontinued.

When driving a vehicle, the drug can affect the speed of reactions, so you should refrain from driving during treatment with this drug.

Children under 5 years of age are not allowed to take the drug.

When taken simultaneously with antacids, the concentration of mefenamic acid in the blood plasma may increase.

Taken together with other non-steroidal drugs may increase the risk of side effects from the gastrointestinal tract.

Drugs such as thiamine, antithrombotic agents, phenothiazine derivatives, pyridoxine can enhance the effect of mefenamic acid.

Analogs

  • Aponil;
  • Artrum;
  • Voltaren;
  • Had;
  • Ketonal;

Price

In Ukraine

  • Capsules 250 mg No. 20 - 18 UAH.
  • Capsules 500 mg No. 29 - 29 UAH.

For residents of Russia

  • Capsules 250 mg. No. 20 - 120 rub.

Shelf life of this drug: in a dry place at temperatures up to 25 degrees. - 5 years.

Mefenamic acid has anti-inflammatory and antipyretic properties. It helps reduce the inflammatory process. This drug improves wound healing. The antipyretic effect of the drug is explained by the fact that Mefenamic acid reduces the production of prostaglandins. The product has an antiviral effect because it improves the process of interferon formation.

In what cases should it be used?

Mefenamic acid is used for inflammatory joint diseases. The drug reduces swelling and relieves inflammation. It can be used for rheumatism and arthritis. The duration of course treatment for joint pathologies can reach two months. Mefenamic acid is effective in the complex treatment of influenza and viral infections.

The medication will help with female problems: it should be used for dysfunctional dysmenorrhea and prolonged uterine bleeding. The drug can be taken for headaches, muscle pain, and postoperative pain.

What dosages are provided?

Mefenamic acid should be taken orally after meals. The medicine should be taken with milk. Children over 12 years of age should drink 250–500 mg of the drug three times a day. The maximum daily dosage is 3000 mg. When positive dynamics are achieved, the dose is reduced to 1000 mg. Children aged five to twelve years should take 250 mg of mefanamic acid no more than four times a day. The duration of treatment is about a month. When therapeutically treating a pain symptom, the drug must be used for at least a week.

What can you say about side effects?

Mefenamic acid causes adverse changes in the body's digestive system. Often when using the drug, abdominal pain, diarrhea and nausea occur. The drug can cause internal bleeding, stomach ulcers, and pancreatitis. It often increases the level of liver enzymes in the blood. Acid also affects the body’s hematopoietic system: it can lead to anemia and thrombocytopenia. This medication may increase blood pressure and change heart rhythm. In rare cases, after taking the medicine, heart failure develops and edema appears.

The acid can cause bronchial spasms and an allergic reaction. It worsens the condition of the kidneys and nervous system. When taking the medicine, the patient's sleep is often disturbed and he becomes irritable. The drug has a negative effect on the senses: when taking this medication, you may experience tinnitus, vision problems, and eye inflammation.

Who is this medicine contraindicated for?

In some cases this medication should not be used:

  • Mefenamic acid should not be taken if you are hypersensitive to the components of the product.
  • This medicine is prohibited for use in cases of gastric ulcers and inflammatory processes in the intestines.
  • It should not be prescribed for severe blood diseases, serious pathologies of the liver and kidneys.
  • Children under five years of age should not take this medicine.
  • The drug should not be used during pregnancy or breastfeeding. The medicine increases the heart rate of the unborn baby.
  • The medication should not be taken by women who are planning to become pregnant in the near future, since after its use problems with conception may appear.

Be careful!

This medicine has a large number of side effects. When treating with this drug, you must exercise caution:

  • This medication should not be used by people who have had heart surgery.
  • The use of this medication is not recommended if you are allergic to Aspirin.
  • Elderly patients may experience adverse complications during treatment.
  • The risk group also includes patients with diabetes, epilepsy, and angina pectoris. Such patients need to reduce the recommended dosage of the drug.
  • If a person has systemic lupus erythematosus, taking the drug is not recommended due to the high likelihood of meningitis.
  • Treatment should be stopped if skin rash and diarrhea appear. With long-term use of the drug, it is necessary to monitor blood parameters and kidney function.
  • This medication dulls the body's natural reaction; when treating with this drug, you need to be careful when operating a car.

Doctor Komarovsky's opinion

A well-known pediatrician does not recommend using Mefenamic acid in the treatment of children. The pediatrician believes that this medicine is highly effective and quickly reduces fever. But the drug contains a large amount of harmful substances, so many developed countries have abandoned the use of this drug as an antipyretic.

Komarovsky writes that to reduce the temperature it is better to use Paracetamol and Ibuprofen. These medicines meet all the necessary requirements. They are effective and suitable for treating young patients.

How to use medicinal paste correctly?

The paste and medicinal solution containing Mefenamic acid must be used within several days, so they should be prepared before use. The paste is used to relieve toothache. The therapeutic course involves at least seven sessions. For ulcers on the oral mucosa, applications are made using an aqueous solution of the product. Such procedures should be carried out up to two times a day.

Useful product based on Mefenamic acid

In addition to this acid, Mephenate ointment contains vilinin. It has a bacteriostatic effect. Vilinin is effective for wound healing. It can be used for trophic ulcers, purulent wounds, burns. This remedy is also prescribed for eczema, boils, and severe cracks in the lips.

The structure of the ointment also contains polyethylene oxide. It reduces the inflammatory process and promotes deep penetration of the ointment into the skin.

The ointment has a local effect, it gives a long-lasting effect. The average duration of action is 10 hours.

The product should be applied to the affected part of the body using a gauze pad twice a day. The product has a slight analgesic effect. The duration of treatment is about 14 days. Sometimes there is irritation in the area where the ointment was applied. The redness usually goes away after a few days.

How does the drug interact with other drugs?

If you use this drug in parallel with taking Analgin, the inflammatory process in the patient will go away much faster. It is not recommended to take other non-steroidal anti-inflammatory drugs. Some doctors believe that in the treatment of acute respiratory diseases, in addition to Mefenamic acid, Immusstat should be used. As research results have shown, these two drugs interact well with each other: they quickly eliminate the unpleasant manifestations of the disease and reduce the likelihood of complications.

Mefenamic acid is a fairly serious medicine, so you should consult your doctor before starting a course of treatment. Under no circumstances should you exceed the recommended dosage of the drug!