Flemoklav solutab for angina in adults dosage. Flemoklav Solutab: a famous antibiotic in a unique form

Amoxicillin and clavulanic acid.

ATX

ATX code - J01C R02.

Release forms and composition

The product is available in tablet form. Dispersible tablets contain two active ingredients: amoxicillin and clavulanic acid. The amount of the first is 250 mg, the second is contained in a volume of 62.5 mg.

Initially the tablets have white. The surface is marked “422”. During storage, yellow spots may form on their surface.

Pharmacological action

The main active component of the drug is amoxicillin. It is a semi-synthetic substance antibacterial action. It has an effect on both gram-positive and gram-negative bacteria.

The active substance is subject to breakdown under the influence of beta-lactamases - enzymes that are produced by some microorganisms to protect against antibiotics. Clavulanic acid, which is contained in the drug, helps amoxicillin cope with bacteria. It inactivates beta-lactamases of microorganisms that are resistant to penicillin antibiotics.

Clavulanic acid prevents the occurrence of cross-resistance because it inhibits the activity of plasmid beta-lactamases, which are responsible for the occurrence of this type of resistance.

The acid maximizes the range of action of the product. It includes the following microorganisms:

1. Gram-positive aerobes: rods anthrax, enterococci, listeria, nocardia, streptococci, coagulose-negative staphylococci.
2. Gram-negative aerobes: Bordetella, Hemophilus influenza and parainfluenza, Helicobacter, Moraxella, Neisseria, Vibrio cholerae.
3. Gram-positive anaerobes: clostridia, peptococci, peptostreptococci.
4. Gram-negative anaerobes: Bacteroides, Fusobacteria, Prevotella.
5. Others: Borrelia, Leptospira.

The following are resistant to the drug:

• citrobacter;
• enterobacter,
• legionella;
• morganella;
• providence;
• pseudomonas;
• chlamydia;
• mycoplasma.

Pharmacokinetics

At orally of the drug, all its components are actively absorbed through the mucous membrane small intestine. The process is accelerated when taking Flemoclav at the beginning of a meal. The biological availability of the drug is about 70%. The maximum effective concentration of both components in the blood is observed after approximately 60 minutes.

Up to 25% of the active components of the drug bind to transport peptides. A certain amount of the product undergoes metabolic transformations.

Most of Flemoclav is excreted through the kidneys. Some clavulanic acid is excreted from the body through the intestines. The half-life of the drug is 60 minutes. The product completely leaves the body in about 24 hours.

What is it prescribed for?

Flemoklav Solutab is prescribed for the treatment the following pathologies caused by microorganisms sensitive to amoxicillin:

• bacterial sinusitis (after laboratory confirmation);
• bacterial lesions of the middle ear;
• diseases of the lower respiratory tract(community-acquired pneumonia, bronchitis, etc.);
• diseases of the genitourinary system (cystitis, pyelonephritis);
• bacterial lesions of the skin and its derivatives (cellulitis, abscesses);
• infectious diseases bones and joints.

Contraindications

The product is contraindicated for use in the following cases:

• the patient has individual hypersensitivity to the active substances or other components of the drug;
• presence in the patient's medical history hypersensitivity to penicillins, cephalosporins, monobactams;
• the patient has a history of jaundice or hepatobiliary tract dysfunction as a result of taking amoxicillin.

With caution

Particular care should be taken by people with liver pathologies and decreased function. urinary system.

How to take Flemoklav Solutab 250

The dosage of the drug should be selected in accordance with the severity of the disease and location pathological process. The patient's age, weight and renal function are also taken into account.

For adults and children weighing over 40 kg, the most commonly prescribed daily dosage is 1.5 g of amoxicillin and 375 mg of clavulanic acid. The drug is taken 3 times a day.

How many days to drink

The duration of therapy is determined by its effectiveness. It is necessary to monitor the eradication of pathological agents. The maximum duration of treatment is 2 weeks.

Before or after meals

Is it possible to take if you have diabetes?

The drug can be taken when diabetes mellitus. Before undergoing a course of treatment, you must consult a specialist.

Side effects

Gastrointestinal tract

The following may appear adverse reactions:

• nausea;
• vomit;
• intestinal disorder;
• pseudomembranous colitis;
• increased activity of liver enzymes;
• hepatitis;
• jaundice.

Blood-forming organs

Possible occurrence:

• transient leukopenia, neutropenia, thrombocytopenia;
• reversible agranulocytosis;
• anemia;
• increased bleeding time.

Central nervous system

May respond to therapy by:

• dizziness;
• headaches;
• sleep disorders;
• seizures;
• hyperactivity.

From the urinary system

Possible appearance:

• jade;
• crystalluria.

From the respiratory system

From the skin

May appear:

• hives;
• erythematous rash;
• exentematous pustulosis;
• pemphigus;
• dermatitis;
• epidermal necrolysis.

From the genitourinary system

No side effects were identified.

Allergies

The following pathological reactions may occur:

• anaphylactic reactions;
• angioedema;
• vasculitis;
• serum sickness.

Special instructions

Alcohol compatibility

Impact on the ability to operate machinery

Be careful when driving and complex mechanisms if any adverse reactions occur nervous system, which negatively affect reaction speed and concentration.

Use during pregnancy and lactation

There were no negative effects of the drug on the fetus during the studies. Flemoklav can also be prescribed during breastfeeding, since the antibiotic does not cause side effects in a child.

How to give Flemoclav Solutab 250 to children

The dosage for children weighing less than 40 kg is selected individually. It is calculated according to the scheme 5-20 mg of amoxicillin per 1 kg of weight. The dosage also depends on the age and severity of the patient's condition.

Dosage in old age

A standard daily dosage is prescribed. Renal function should be checked in order to adjust the dose if necessary.

Use for renal impairment

A decrease in creatinine clearance is a reason for selecting individual daily dosage. When the rate decreases to 10-30 ml/min, the patient should take 500 mg of amoxicillin 2 times a day. If clearance decreases to 10 ml/min or less, the same dose of the drug is taken 1 time per day.

Use for liver dysfunction

Overdose

The use of high doses of the drug may be accompanied by the appearance of side symptoms from the gastrointestinal tract and electrolyte imbalance. Symptoms of overdose are eliminated with symptomatic treatment. Hemodialysis may be used.

Interaction with other drugs

Aminoglycosides, glucosamine, antacids slow down absorption active ingredients drug. Vitamin C increases absorption activity.

An antagonistic effect is observed when Flemoclav Solutab is used together with bacteriostatic antibiotics. The drug synergizes with Rifampicin, Cephalosporin and other antibacterial agents with bactericidal action.

With simultaneous use of amoxicillin with methotrexate, the rate of elimination of the latter is reduced. This leads to an increase in its toxicity.

Analogues

Analogues of this drug are:

• Abiklav;
• A-Klav;
• Amoxi-Alo-Clav;
• Amoxicomb;
• Augmentin;
• Betaclave;
• Clavicillin;
• Clavamatine;
• Michaelv;
• Panclave;
• Rapiklav.

Conditions for dispensing Flemoklav 250 from pharmacies

According to the doctor's prescription.

Can I buy it without a prescription?

Price

Depends on the place of purchase.

Storage conditions of the drug

Must be stored at a temperature not exceeding +25°C.

Best before date

Suitable for use within 3 years from the date of issue.

Manufacturer Flemoklava 250

The drug is manufactured by Astellas Pharma Europe.

Flemoclav Solutab | analogues

The drug Flemaxin solutab, instructions. Diseases of the genitourinary system

The page contains instructions for use Flemoklava Solutab. It is available in various dosage forms drug (tablets 125 mg, 250 mg, 500 mg, 875 mg and 1000 mg dispersible), and also has a number of analogues. This abstract has been verified by experts. Leave your feedback on the use of Flemoclav Solutab, which will help other site visitors. The drug is used for various diseases (sore throat, bronchitis, sinusitis, otitis media and other infectious diseases). The product has a number of side effects and interactions with other substances. Doses of the drug differ for adults and children. There are restrictions on the use of the medicine during pregnancy and breastfeeding. Treatment with Flemoclav Solutab can only be prescribed by a qualified doctor. The duration of therapy may vary and depends on the specific disease.

Instructions for use and dosage

For adults and children over 12 years of age and children under 12 years of age weighing more than 40 kg, Flemoclav Solutab at a dose of 875 mg/125 mg is prescribed 2 times a day (every 12 hours).

Children under 12 years of age weighing less than 40 kg are prescribed Flemoclav Solutab in lower dosages.

For adults and children weighing more than 40 kg, the drug is prescribed 500 mg/125 mg 3 times a day. For severe, chronic, recurrent infections, this dose can be doubled.

The daily dose for children is usually 20-30 mg of amoxicillin and 5-7.5 mg of clavulanic acid per kg of body weight. Possible mode dosage for children depending on the age and body weight of the child:

• age from 3 months to 2 years - body weight from 5 to 12 kg - daily dose of tablet 125 mg/31.25 mg 2 times a day;
• age from 2 to 7 years - body weight from 13 to 25 kg - daily dose of tablet 125 mg/31.25 mg 3 times a day;
• age from 7 to 12 years - body weight from 25 to 37 kg - daily dose of tablet 250 mg/62.5 mg 3 times a day.

For severe infections, these doses can be doubled (the maximum daily dose is 60 mg amoxicillin and 15 mg clavulanic acid per kg body weight).

The duration of treatment depends on the severity of the infection and should not exceed 14 days unless necessary.

To prevent side effects from digestive system The drug is recommended to be taken at the beginning of a meal. The tablet is swallowed whole with a glass of water, or dissolved in half a glass of water (minimum 30 ml), stirring thoroughly before use (a suspension is obtained that is convenient for children to take).

Release forms

Dispersible tablets 125 mg, 250 mg, 500 mg, 625 mg, 875 mg and 1000 mg.

There are no other forms of release, be it syrup, injections in ampoules or capsules.

Compound

Amoxicillin trihydrate (Amoxicillin) + Potassium clavulanate (Clavulanic acid) + excipients.

Flemoklav solutab- broad-spectrum antibiotic; a combination drug of amoxicillin and clavulanic acid, a beta-lactamase inhibitor. Active against gram-positive and gram-negative microorganisms (including strains producing beta-lactamases).

Amoxicillin is bactericidal and inhibits the synthesis of peptidoglycan in the bacterial cell wall. Clavulanic acid inhibits beta-lactamases types 2, 3, 4 and 5. Not active against type 1 beta-lactamases produced by Enterobacter spp., Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high affinity for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases and expands its spectrum of action.

Flemoklav Solutab is active against aerobic and anaerobic gram-positive bacteria, aerobic and anaerobic gram-negative bacteria.

Pharmacokinetics

Amoxicillin

After oral administration, it is quickly absorbed from the gastrointestinal tract. Absorption of amoxicillin after oral administration is 90-94%. Concomitant food intake does not affect absorption. Amoxicillin penetrates the placental barrier and into small quantities excreted in breast milk. Approximately 60-80% of amoxicillin is excreted through the kidneys during the first 6 hours after taking the drug.

Clavulanic acid

After oral administration, it is quickly absorbed from the gastrointestinal tract. Absolute bioavailability is approximately 60%. Concomitant food intake does not affect absorption. Serum protein binding is 22%. Clavulanic acid penetrates the placental barrier. There is no reliable data on excretion in breast milk. Clavulanic acid undergoes extensive metabolism through hydrolysis and subsequent decarboxylation. Approximately 30-50% of clavulanic acid is excreted through the kidneys during the first 6 hours after taking the drug.

Indications

• bacterial infections caused by sensitive pathogens: lower respiratory tract infections (bronchitis (acute and exacerbation of chronic), pneumonia, pleural empyema, lung abscess);
• infections of the ENT organs (sinusitis, tonsillitis, tonsillitis, otitis media);
• infections of the genitourinary system and pelvic organs (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingoophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, septic abortion, postpartum sepsis, pelvioperitonitis, chancroid, gonorrhea);
• infections of the skin and soft tissues (erysipelas, impetigo, secondary infected dermatoses, abscess, cellulitis, wound infection);
• osteomyelitis;
• postoperative infections;
• prevention of infections in surgery.

Contraindications

• liver dysfunction (including jaundice) with a history of taking amoxicillin/clavulanic acid;
• infectious mononucleosis;
• lymphocytic leukemia;
• renal failure(glomerular filtration less than 30 ml/min) - for dispersible tablets 875 mg/125 mg;
• children under 12 years of age weighing less than 40 kg (for dispersible tablets 875 mg/125 mg);
• hypersensitivity to amoxicillin, clavulanic acid and other components of the drug;
• hypersensitivity to other beta-lactam antibiotics (penicillins and cephalosporins).

Special instructions

When taking Flemoclav Solutab, there is a possibility of cross-resistance and hypersensitivity with other penicillins or cephalosporins.

In case of development anaphylactic reactions the drug should be stopped immediately and appropriate therapy administered: treatment of anaphylactic shock may require urgent administration of epinephrine (adrenaline), glucocorticosteroids (GCS) and elimination of respiratory failure.

Superinfection (eg, candidiasis) may develop, especially in patients with chronic diseases and/or dysfunction immune system. If superinfection occurs, the drug is discontinued and/or antibacterial therapy is adjusted accordingly.

For patients with severe gastrointestinal disorders accompanied by vomiting and/or diarrhea, the administration of Flemoklav Solutab is not advisable until the above symptoms are eliminated, because Possible disruption of drug absorption from the gastrointestinal tract.

The appearance of severe and persistent diarrhea may be associated with the development of pseudomembranous colitis, in which case the drug is discontinued and prescribed necessary treatment. In case of development of hemorrhagic colitis, immediate discontinuation of the drug and corrective therapy are also necessary. The use of drugs that weaken intestinal motility in these cases is contraindicated.

If liver function is impaired, the drug should be prescribed with caution and under constant medical supervision. The drug should not be used for more than 14 days without assessing liver function.

In a single study prophylactic appointment amoxicillin/clavulanate in women with premature rupture of membranes increased the risk of developing necrotizing enterocolitis in newborns.

While taking the drug, an increase in prothrombin time may be observed. Therefore, Flemoklav Solutab should be prescribed with caution to patients receiving anticoagulant therapy (blood clotting parameters must be monitored).

Due to high concentration amoxicillin in the urine, it can be deposited on the walls urinary catheter Therefore, such patients require periodic catheter changes. Forced diuresis accelerates the elimination of amoxicillin and reduces its plasma concentration.

During the period of use of Flemoclav Solutab, non-enzymatic methods for determining glucose in urine, as well as a test for urobilinogen, may give false positive results.

During a course of treatment, it is necessary to monitor the functions of the hematopoietic organs, liver and kidneys.

If seizures occur during therapy, the drug is discontinued.

It should be noted that 1 dispersible tablet 875 mg/125 mg contains 25 mg of potassium.

Side effect

• thrombocytosis, hemolytic anemia, leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, anemia;
• increase in prothrombin time and bleeding time;
• dizziness;
• headache;
• convulsions;
• anxiety;
• anxiety;
• insomnia;
• disturbance of consciousness;
• aggressive behavior;
• vasculitis;
• abdominal pain;
• nausea, vomiting;
• flatulence;
• diarrhea;
• pseudomembranous colitis (in case of severe and persistent diarrhea while taking the drug or within 5 weeks after completion of therapy);
• intestinal candidiasis;
• hemorrhagic colitis;
• cholestatic jaundice;
• itching, burning and vaginal discharge;
• interstitial nephritis;
• skin rash and itching;
• morbilliform exanthema;
• hives;
• bullous or exfoliative dermatitis (multiform exudative erythema, Stevens-Johnson syndrome, toxic epidermal necrolysis);
• anaphylactic shock;
• drug fever;
• eosinophilia;
• angioedema (Quincke's edema);
• swelling of the larynx;
• serum sickness;
• hemolytic anemia;
• allergic vasculitis;
• bacterial or fungal superinfections (with long-term therapy or repeated courses of therapy).

Drug interactions

When used simultaneously with some bacteriostatic drugs (for example, chloramphenicol, sulfonamides), antagonism with amoxicillin/clavulanic acid was observed.

Flemoklav solutab should not be prescribed simultaneously with disulfiram.

Concomitant use of drugs that inhibit the renal excretion of amoxicillin (probenecid, phenylbutazone, oxyphenbutazone and, to a lesser extent, acetylsalicylic acid, indomethacin and sulfinpyrazone), helps to increase the concentration and longer presence of amoxicillin in the blood plasma and bile. The excretion of clavulanic acid is not impaired.

When used simultaneously with Flemoklav Solutab, antacids, glucosamine, laxatives, aminoglycosides slow down and reduce the absorption of amoxicillin, ascorbic acid increases the absorption of amoxicillin.

Concomitant use of Flemoclav Solutab with allopurinol may increase the risk of developing a skin rash.

Ethanol (alcohol) reduces the rate of absorption of Amoxicillin in the gastrointestinal tract.

Aminopenicillins may decrease serum concentrations of sulfasalazine.

Amoxicillin reduces the renal clearance of methotrexate, which may lead to an increased risk of methotrexate. toxic effect. At simultaneous administration with amoxicillin, monitoring of serum methotrexate concentrations is necessary.

Concomitant use of amoxicillin/clavulanic acid and digoxin may result in increased absorption of digoxin.

With the simultaneous use of Flemoclav Solutab and indirect anticoagulants possible increased risk of bleeding.

IN in rare cases While taking amoxicillin, a decrease in the effectiveness of oral contraceptives was observed, so the patient should be advised to use non-hormonal methods of contraception.

Analogues medicinal product Flemoklav solutab

Structural analogues of the active substance:

• Amovycombe;
• Amoxiclav;
• Amoxiclav Quiktab;
• Amoxicillin + Clavulanic acid Pfizer;
• Arlet;
• Augmentin;
• Bactoclav;
• Verklav;
• Clamosar;
• Liklav;
• Honeyclave;
• Panclave;
• Ranklav;
• Rapiklav;
• Taromentin;
• Fibell;
• Ecoclave.

Use during pregnancy and breastfeeding

When using Flemoklav Solutab during pregnancy, it was not observed negative influence to the fetus or newborn. The use of the drug in the 2nd and 3rd trimester of pregnancy is possible after a medical assessment of the risk/benefit. In the 1st trimester of pregnancy, the use of Flemoclav Solutab should be avoided (only for dispersible tablets 875 mg/125 mg). Dispersible tablets 125 mg/31.25 mg, 250 mg/62.5 mg, 500 mg/125 mg in the 1st trimester of pregnancy should be prescribed with caution.

Amoxicillin and clavulanic acid penetrate the blood-placental barrier and are excreted in breast milk. It is possible to use the drug during breastfeeding.

If a child develops sensitization, diarrhea or candidiasis of the mucous membranes, breastfeeding should be stopped.

Before using FLEMOCLAV SOLUTAB you should consult your doctor. These instructions for use are for informational purposes only. To get more complete information Please refer to the manufacturer's instructions.

Clinical and pharmacological group

06.007 (Broad-spectrum penicillin antibiotic with beta-lactamase inhibitor)

Release form, composition and packaging

Dispersible tablets, oblong, white to yellow with brown dotted spots, without marks, marked “421” and the company logo.

Dispersible tablets are oblong, from white to yellow in color with brown dotted spots, without marks, marked “422” and the company logo.

Excipients: microcrystalline cellulose, crospovidone, vanillin, apricot flavor, saccharin, magnesium stearate.

4 pcs. - blisters (5) - cardboard packs.

Dispersible tablets are oblong, from white to yellow in color with brown dotted spots, without marks, marked “424” and the company logo.

Excipients: microcrystalline cellulose, crospovidone, vanillin, apricot flavor, saccharin, magnesium stearate.

4 pcs. - blisters (5) - cardboard packs.

Dispersible tablets, oblong, from white to yellow, without marks, marked “425” and a graphic part of the company logo; brown dotted spots are allowed.

Excipients: dispersed cellulose, microcrystalline cellulose, crospovidone, vanillin, tangerine flavor, lemon flavor, saccharin, magnesium stearate.

7 pcs. - blisters (2) - cardboard packs.

Pharmacological action

Broad-spectrum antibiotic; a combination drug of amoxicillin and clavulanic acid, a β-lactamase inhibitor. Active against gram-positive and gram-negative microorganisms (including strains producing β-lactamases).

Amoxicillin is bactericidal and inhibits the synthesis of peptidoglycan in the bacterial cell wall. Clavulanic acid inhibits β-lactamases types II, III, IV and V. Not active against type I β-lactamases produced by Enterobacter spp., Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high affinity for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of β-lactamases and expands its spectrum of action.

Flemoclav Solutab® is active against aerobic gram-positive bacteria: Streptococcus spp., Staphylococcus spp. (except methicillin-resistant strains), Enterococcus spp., Corynebacterium spp., Bacillus anthracis, Listeria monocytogenes; anaerobic gram-positive bacteria: Clostridium spp. (except Clostridium difficile), Peptococcus spp., Peptostreptococcus spp.; aerobic gram-negative bacteria: Escherichia coli, Klebsiella spp., Proteus spp., Yersinia enterocolitica, Salmonella spp., Shigella spp., Haemophilus influenzae, Haemophilus ducreyi, Neisseria gonorrhoeae, Neisseria meningitidis, Bordetella pertussis, Moraxella catarrhalis, Gardnerella vaginalis, Brucella spp., Pasteurella multocida, Vibrio cholerae, Helicobacter pylori; anaerobic gram-negative bacteria: Bacteroides spp., including Bacteroides fragilis, Fusobacterium spp.

Pharmacokinetics

Amoxicillin

Suction

After oral administration, it is quickly absorbed from the gastrointestinal tract. Absorption of amoxicillin after oral administration is 90-94%. Absolute bioavailability reaches 94%. Concomitant food intake does not affect absorption.

Cmax in blood plasma is achieved 1-2 hours after administration. After taking a single dose of 500 mg/125 mg (amoxicillin/clavulanic acid), the average concentration of amoxicillin (after 8 hours) is 0.3 mg/l.

After a single dose of 875 mg/125 mg (amoxicillin/clavulanic acid), the Cmax of amoxicillin in blood plasma is 12 mcg/ml.

Distribution

After a single dose of 875 mg/125 mg (amoxicillin/clavulanic acid), the AUC of amoxicillin is 33 mcg x h/l. Serum protein binding is approximately 17-20%.

Amoxicillin crosses the placental barrier and is excreted in small quantities into breast milk.

Metabolism

A small part of amoxicillin is metabolized by hydrolysis of the beta-lactam ring to inactive metabolites (the main ones are penicillic and penamaldic acids).

Removal

Approximately 60-80% of amoxicillin is excreted through the kidneys during the first 6 hours after taking the drug. T1/2 is 0.9-1.2 hours.

In case of impaired renal function (creatinine clearance within 10-30 ml/min), T1/2 is 6 hours, and in the case of anuria it ranges between 10 and 15 hours. It is excreted by hemodialysis.

Clavulanic acid

Suction

After oral administration, it is quickly absorbed from the gastrointestinal tract. Absolute bioavailability is approximately 60%. Concomitant food intake does not affect absorption. Cmax in blood plasma is achieved approximately 1-2 hours after administration. After taking a single dose of 500/125 mg (amoxicillin/clavulanic acid), the average concentration of clavulanic acid reaches 0.08 mg/l (after 8 hours).

After a single dose of 875 mg/125 mg (in blood plasma is 3 mcg/ml.

Distribution

Following a single dose of 875 mg/125 mg (amoxicillin/clavulanic acid), the AUC of clavulanic acid is 6 mcg x h/L.

Serum protein binding is 22%. Clavulanic acid penetrates the placental barrier. There is no reliable data on excretion in breast milk.

Metabolism

Clavulanic acid undergoes extensive metabolism through hydrolysis and subsequent decarboxylation.

Removal

Approximately 30-50% of clavulanic acid is excreted through the kidneys during the first 6 hours after taking the drug. T1/2 is approximately 1 hour.

The total clearance for amoxicillin and clavulanic acid is 25 l/h.

Pharmacokinetics in special clinical situations

In case of impaired renal function (creatinine clearance from 20 to 70 ml/min), T1/2 is 2.6 hours, and in case of anuria it ranges from 3-4 hours. It is excreted by hemodialysis.

FLEMOCLAV SOLUTAB: DOSAGE

For adults and children over 12 years of age and children under 12 years of age weighing more than 40 kg, Flemoclav Solutab® at a dose of 875 mg/125 mg is prescribed 2 times a day (every 12 hours).

Children under 12 years of age weighing less than 40 kg are prescribed Flemoclav.

For adults and children weighing more than 40 kg, the drug is prescribed 500 mg/125 mg 3 times a day. For severe, chronic, recurrent infections, this dose can be doubled.

A possible dosage regimen for children is presented in the table. The daily dose is usually 20-30 mg of amoxicillin and 5-7.5 mg of clavulanic acid per kg of body weight.

For severe infections, these doses can be doubled (the maximum daily dose is 60 mg amoxicillin and 15 mg clavulanic acid per kg body weight).

The duration of treatment depends on the severity of the infection and should not exceed 14 days unless necessary.

Flemoclav Solutab® at a dose of 875 mg/125 mg can only be used at speed glomerular filtration more than 30 ml/min. In this case, no dose adjustment is required.

In case of liver dysfunction, the drug should be prescribed with caution. It is necessary to monitor liver function.

To prevent side effects from the digestive system, it is recommended to take the drug at the beginning of a meal. The tablet is swallowed whole with a glass of water, or dissolved in half a glass of water (minimum 30 ml), stirring thoroughly before use.

Age
Body weight
Daily dose
from 3 months to 2 years
from 5 to 12 kg
tablets 125 mg/31.25 mg 2 times/day
from 2 to 7 years
from 13 to 25 kg
tablets 125 mg/31.25 mg 3 times/day
from 7 to 12 years
from 25 to 37 kg
tablets 250 mg/62.5 mg 3 times/day
Glomerular filtration rate
Adults
Children
10-30 ml/min
500 mg 2 times/day
15 mg/kg 2 times/day
less than 10 ml/min
500 mg/day
15 mg/kg/day
hemodialysis

Overdose

Symptoms: nausea, vomiting, diarrhea with possible violations water and electrolyte balance.

Treatment: prescribed activated carbon and osmodiuretics, it is necessary to maintain water and electrolyte balance, and carry out symptomatic therapy. For convulsions, diazepam is prescribed. In case of severe renal failure, hemodialysis is performed.

Drug interactions

When used concomitantly with certain bacteriostatic drugs (for example, chloramphenicol, sulfonamides), antagonism with amoxicillin/clavulanic acid in vitro was observed.

Amoxicillin/clavulanic acid should not be co-administered with disulfiram.

The simultaneous use of drugs that inhibit the renal excretion of amoxicillin (probenecid, phenylbutazone, oxyphenbutazone and, to a lesser extent, acetylsalicylic acid, indomethacin and sulfinpyrazone) increases the concentration and longer presence of amoxicillin in the blood plasma and bile. The excretion of clavulanic acid is not impaired.

When used simultaneously with Flemoklav Solutab®, antacids, glucosamine, laxatives, aminoglycosides slow down and reduce the absorption of amoxicillin, while ascorbic acid increases the absorption of amoxicillin.

Concomitant use of Flemoclav Solutab® with allopurinol may increase the risk of developing a skin rash.

Aminopenicillins may decrease serum concentrations of sulfasalazine.

Amoxicillin reduces the renal clearance of methotrexate, which may lead to an increased risk of toxicity. When taken concomitantly with amoxicillin, monitoring of the concentration of methotrexate in the blood serum is necessary.

Concomitant use of amoxicillin/clavulanic acid and digoxin may result in increased absorption of digoxin.

With the simultaneous use of Flemoclav Solutab® and indirect anticoagulants, the risk of bleeding may increase.

In rare cases, while taking amoxicillin, a decrease in the effectiveness of oral contraceptives has been observed, so the patient should be advised to use non-hormonal methods of contraception.

Pregnancy and lactation

When using Flemoclav Solutab® during pregnancy, no negative effects on the fetus or newborn were noted. Use of the drug in II and III trimester pregnancy is possible after a medical assessment of the risks/benefits. In the first trimester of pregnancy, the use of Flemoclav Solutab® should be avoided (only for dispersible tablets 875 mg/125 mg). Dispersible tablets 125 mg/31.25 mg, 250 mg/62.5 mg, 500 mg/125 mg in the first trimester of pregnancy should be prescribed with caution.

Amoxicillin and clavulanic acid penetrate the blood-placental barrier and are excreted in breast milk. It is possible to use the drug during the period.

If a child develops sensitization, diarrhea or candidiasis of the mucous membranes, breastfeeding should be stopped.

FLEMOCLAV SOLUTAB: SIDE EFFECTS

Frequency of occurrence adverse events classified as follows: often (≥1/100,

From the hematopoietic system: rarely - thrombocytosis, hemolytic anemia; very rarely - leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, anemia. These adverse reactions are reversible and disappear after discontinuation of therapy.

From the coagulation system: very rarely - an increase in prothrombin time and bleeding time. These adverse reactions are reversible and disappear after discontinuation of therapy.

From the nervous system: rarely - dizziness, headache, convulsions (in case of impaired renal function or drug overdose); very rarely - hyperactivity, restlessness, anxiety, insomnia, impaired consciousness, aggressive behavior.

From the outside cardiovascular system: rarely - vasculitis.

From the digestive system: often - abdominal pain, nausea (more often with overdose), vomiting, flatulence, diarrhea (generally, reactions from the digestive system are transient and rarely pronounced; their intensity can be reduced by taking the drug at the beginning of treatment food); pseudomembranous colitis (in case of severe and persistent diarrhea while taking the drug or within 5 weeks after completion of therapy), in most cases caused by Clostridium difficile; rarely - intestinal candidiasis, hemorrhagic colitis, discoloration of the surface layer of tooth enamel.

From the liver: often - slight increase liver enzyme activity; rarely - hepatitis and cholestatic jaundice. Symptoms of liver dysfunction occur during treatment or immediately after stopping therapy, but in some cases they may appear several weeks after stopping the drug; more often observed in men and patients over 60 years of age; observed very rarely in children (

From the genitourinary system: infrequently - itching, burning and vaginal discharge; rarely - interstitial nephritis.

Allergic reactions: often - skin rash and itching; morbilliform exanthema, appearing 5-11 days after the start of therapy. The appearance of urticaria immediately after starting to take the drug is highly likely to be a manifestation of an allergic reaction and requires discontinuation of the drug. Rarely - bullous or exfoliative dermatitis (erythema multiforme exudative, Stevens-Johnson syndrome, toxic epidermal necrolysis), anaphylactic shock, drug fever, eosinophilia, angioedema (Quincke's edema), laryngeal edema, serum sickness, hemolytic anemia, allergic vasculitis, interstitial nephritis .

Other: uncommon - bacterial or fungal superinfections (with long-term therapy or repeated courses of therapy).

Storage conditions and periods

List B. The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 3 years. The shelf life of dispersible tablets 875 mg/125 mg is 2 years.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• infections of the upper respiratory tract and ENT organs (incl.
• otitis media,
• sinusitis,
• tonsillitis,
• pharyngitis);
• lower respiratory tract infections (incl.
• exacerbation of chronic bronchitis,
• COPD,
• community-acquired pneumonia);
• infections of bones and joints,
• incl.
• osteomyelitis (only for tablets 875 mg/125 mg);
• infections in obstetrics and gynecology (only for tablets 875 mg/125 mg);
• skin and soft tissue infections;
• kidney infections and urinary tract(incl.
• cystitis,
• pyelonephritis).

Contraindications

• liver dysfunction (incl.
• jaundice) with a history of taking amoxicillin/clavulanic acid;
• infectious mononucleosis;
• lymphocytic leukemia;
• renal failure (glomerular filtration ≤ 30 ml/min) - for dispersible tablets 875 mg/125 mg;
• children under 12 years of age weighing less than 40 kg (for dispersible tablets 875 mg/125 mg);
• hypersensitivity to amoxicillin,
• clavulanic acid and other components of the drug;
• hypersensitivity to other beta-lactam antibiotics (penicillins and cephalosporins).

The drug should be prescribed with caution in case of severe liver failure, chronic renal failure, gastrointestinal diseases (including a history of colitis associated with the use of penicillins).

Special instructions

When taking Flemoclav Solutab®, there is a possibility of cross-resistance and hypersensitivity with other penicillins or cephalosporins.

If anaphylactic reactions develop, the drug should be stopped immediately and appropriate therapy administered: treatment of anaphylactic shock may require urgent administration of epinephrine (adrenaline), corticosteroids and elimination of respiratory failure.

Superinfection (for example, candidiasis) may develop, especially in patients with chronic diseases and/or impaired immune system function. If superinfection occurs, the drug is discontinued and/or antibacterial therapy is adjusted accordingly.

For patients with severe gastrointestinal disorders accompanied by vomiting and/or diarrhea, the administration of Flemoclav Solutab® is not advisable until the above symptoms are eliminated, because Possible disruption of drug absorption from the gastrointestinal tract.

The appearance of severe and persistent diarrhea may be associated with the development of pseudomembranous colitis, in which case the drug is discontinued and the necessary treatment is prescribed. In case of development of hemorrhagic colitis, immediate discontinuation of the drug and corrective therapy are also necessary. The use of drugs that weaken intestinal motility in these cases is contraindicated.

If liver function is impaired, the drug should be prescribed with caution and under constant medical supervision. The drug should not be used for more than 14 days without assessing liver function.

In a single study, prophylactic amoxicillin/clavulanate in women with premature rupture of membranes increased the risk of neonatal necrotizing enterocolitis.

While taking the drug, an increase in prothrombin time may be observed. Therefore, Flemoklav Solutab® should be prescribed with caution to patients receiving anticoagulant therapy (blood clotting parameters must be monitored).

Due to the high concentration of amoxicillin in the urine, it can be deposited on the walls of the urinary catheter, so such patients require periodic catheter changes. Forced diuresis accelerates the elimination of amoxicillin and reduces its plasma concentration.

During the period of use of Flemoklav Solutab®, non-enzymatic methods for determining glucose in urine, as well as a test for urobilinogen, may give false positive results.

During a course of treatment, it is necessary to monitor the functions of the hematopoietic organs, liver and kidneys.

If seizures occur during therapy, the drug is discontinued.

It should be noted that 1 dispersible tablet 875 mg/125 mg contains 25 mg of potassium.

Use for renal impairment

The drug should be prescribed with caution in chronic renal failure.

If renal function is impaired, the excretion of clavulanic acid and amoxicillin by the kidneys slows down. Depending on the severity of renal failure, the dose of Flemoclav Solutab® (calculated as amoxicillin) should not exceed that presented in the table.

Creatinine clearance
Adults
Children
10-30 ml/min
500 mg 2 times/day
15 mg/kg 2 times/day
less than 10 ml/min
500 mg/day
15 mg/kg/day
hemodialysis
500 mg/day and 500 mg during and after dialysis
15 mg/kg/day and 15 mg/kg during and after dialysis

Use for liver dysfunction

The drug should be prescribed with caution in severe liver failure.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Registration numbers

tab. dispersible 875 mg+125 mg: 14 pcs. LSR-000392/09 (2026-01-09 – 0000-00-00) tab. dispersible 250 mg+62.5 mg: 20 pcs. P N016067/01 (2017-11-09 – 0000-00-00) tab. dispersible 500 mg+125 mg: 20 pcs. P N016067/01 (2017-11-09 – 0000-00-00) tab. dispersible 125 mg+31.25 mg: 20 pcs. P N016067/01 (2017-11-09 – 0000-00-00)

“Flemoklav” refers to combined broad-spectrum antibacterial agents and is actively used in therapeutic and pediatric practice, mainly for the treatment of pathologies of the human respiratory and genitourinary systems. The drug consists of two components - the penicillin antibiotic amoxicillin and the penicillinase inhibitor clavulanic acid. For the first time this combination was synthesized in 1978 by the British pharmaceutical company"Beecham." The drug began to be prescribed a few years later, and it quickly found its niche in the treatment of infectious bacterial pathologies.

Pharmaceutical properties of the drug

Amoxicillin

Amoxicillin is a semisynthetic drug from the penicillin group. By chemical structure it is close to ampicillin, from which it differs in the presence of an additional hydroxyl compound. Amoxicillin is capable of selectively inhibiting transpeptidase and disrupting the synthesis of bacterial cell membrane components, which leads to their lysis and death. This mechanism of action is called bactericidal. The following microorganisms are sensitive to the drug:

In touch with active use amoxicillin in clinical practice The following bacteria develop resistance to it:

• Klebsiella;
• Proteus;
• salmonella;
• Escherichia;
• citrobacter;
• actinobacter;
• chlamydia;
• mycoplasma;
• Coxiella.

Amoxicillin is well and quickly absorbed from the intestine when administered orally. The medication does not penetrate the blood-brain barrier well, so it is not recommended for use for meningitis.

However high content antibiotic is registered in bile, organ secretions respiratory system, pleural fluid, adipose, soft tissues and in the fetus. Amoxicillin is partially metabolized in the liver, but the rest of the drug is excreted in an active state by the kidneys within a few hours after administration.

Clavulanic acid belongs to the group of beta-lactamase inhibitors. It is able to bind and create strong complexes with penicillinase types 2, 3, 4 and 5. Thus, this substance prevents bacteria from breaking down amoxicillin. Clavulanic acid has no effect on penicillinase type 1. It significantly increases the sensitivity of streptococci, staphylococci, pneumococci, gonococci, chlamydia and legionella. But enterococci, Pseudomonas aeruginosa and some strains of Haemophilus influenzae remain resistant to it.

Clavulanic acid is well absorbed from the digestive tract, and the maximum concentration is reached after 60 minutes. It partially binds to blood proteins. It is also excreted from the body by the kidneys.

Approximately 5-6 hours after administration, only half of the initial dose of the drug remains in the body.

Combined properties of the drug

The combined use of clavulanic acid with amoxicillin allows you to expand the spectrum of antibacterial action of the drug. Studies have also shown that it also increases the activity of the body's immune system by enhancing the bactericidal activity of white blood cells.

At the same time, the body’s resistance to all microorganisms increases, and not just those producing penicillinase. Additionally, clavulanic acid enhances the processes of chemotaxis and adhesion of immune system cells to pathogenic pathogens. This action is especially important in the treatment of pneumococcal pneumonia.

The antibiotic Flemoklav Solutab has a special property - its active molecules are in the form of microspheres, which protects them from exposure to foreign substances and high acidity stomach. That's why this drug has higher bioavailability than its other analogues.

Indications for use of "Flemoklav"

"Flemoklav" is prescribed for the following bacterial inflammatory pathologies in a patient:

The combination of amoxicillin and clavulanic acid today remains the first-line drug for treatment bacterial infections respiratory system and ENT organs on an outpatient basis. Special significance The drug is suitable for children, since it can be prescribed as early as 2 years of age.

Contraindications for taking Flecoclave

Flemoclav should not be prescribed if the patient has had any previous episodes of any allergic reaction not only to the components of the drug, but also to all beta-lactam antibiotics (penicillins, cephalosporins, carbapenems and monobactams).

It is also prohibited to use the drug in persons who have acute pathology liver with a decrease in its function.

If there are symptoms of liver failure, it is necessary to approach the prescription of Flemoclav with great caution, since in such patients the half-life of the antibiotic increases. At the usual dosage, this can lead to the accumulation of the drug in the body and the appearance of overdose symptoms.

In case of mononucleosis, taking Flemoklav is strictly prohibited. Numerous cases of exanthema rash occurring in patients after prescribing medications containing amoxicillin have been described. Toxic liver damage is also sometimes observed varying degrees gravity.

For phenylketonuria ( hereditary pathology with impaired amino acid metabolism), the use of "Flemoklav" leads to increased toxic damage central nervous system.

The drug should also be prescribed with caution during pregnancy and lactation. Although it is considered virtually non-toxic to the fetus, there has not been a huge amount of research on this topic.

Side effects

In most patients, the use of Flemoklav does not cause any side effects. However, cases of the development of some undesirable symptoms have been described:

• allergic reactions varying degrees of severity (rash, anaphylactic shock, erythema);
• dyspeptic manifestations (nausea, vomiting, constipation, flatulence, heaviness in the abdomen, a feeling of bitterness in the mouth);
• toxic effects on the kidneys due to their functional failure (interstitial nephritis);
• impaired tolerance of the immune system (development of angioedema, exacerbation of systemic vasculitis);
• acute skin lesions (Stevens-Johnson syndrome);
• toxic liver damage (jaundice, decreased cognitive processes, increased body temperature, changes in the color of urine, increased size of the organ).

Of particular importance is the ability of the drug to inhibit hematopoiesis in some patients. Laboratory tests in such cases indicate a decrease in the number of blood cells (anemia, leukocytopenia, lymphocytopenia, reticulocytopenia, thrombocytopenia). Against this background, it is possible that a secondary bacterial or viral infection, the appearance of hemorrhages in the skin and mucous membranes.

With prolonged use of the drug, pseudomembranous colitis sometimes occurs. The reason for its development is the active reproduction of the anaerobic pathogen Clostridium difficile in the intestinal lumen. The severity of the disease depends on the extent of the damage digestive tract and severity of intoxication syndrome. In most cases, only fever, diarrhea, nausea and vomiting are observed. But it’s not uncommon serious complications- intestinal perforation or megalocolon.

If side effects occur, you should immediately consult your doctor. He must assess the patient’s condition and decide on the advisability of further use of Flemoclav.

Release form

Flemoklav is produced by the Dutch pharmaceutical company Astellas Pharma Europa B.V. One package contains 20 or 14 tablets for internal use. In most cases, it is usually sufficient for a course of treatment. There are several types of Flemoclav dosage:

• 250 mg amoxicillin and 62.5 mg clavulanic acid;
• 500 mg amoxicillin and 125 mg clavulanic acid;
• 875 mg amoxicillin and 125 mg clavulanic acid.

Interaction with other drugs

According to the instructions, “Flemoklav” cannot be used together with other bacteriostatic drugs (macrolides, tetracyclines and others). Their joint use reduces the effectiveness of these drugs.

Simultaneous administration with methotraxate and other cytostatics increases toxic effect on the liver, so they cannot be combined in case of insufficiency liver function. When using alopurinol, the risk of developing allergic skin reactions increases.

Flemoclav should not be prescribed together with probenecid, which is used to treat gout. This drug can reduce the excretion of amoxicillin from the body, which leads to its accumulation in tissues and the development of overdose symptoms.

When administered simultaneously with anticoagulant drugs, an increase in prothrombin time is observed. Therefore, the doctor must constantly monitor general condition similar patients.

Method of use and dosage of "Flemoklav"

The drug is recommended to be used before meals. The tablet can be swallowed whole, dissolved in a small amount of liquid before use, or chewed. It is also recommended to drink it sufficient quantity ordinary water(about a glass).

For adults and children weighing more than 40 kilograms, the antibiotic Flemoklav is usually prescribed at a dosage of 500/125 mg 3 times a day. In case of severe pathology or the development of complications, the dose of the drug can be increased to 875/125 mg. The maximum daily amount of the drug should not exceed 60 mg of amoxicillin and 15 mg of clavulanic acid per 1 kg of patient body weight. The duration of treatment is usually from 5 to 14 days.

For children weighing 25-39 kg (approximate age 7-12 years), Flemoklav should be prescribed 250/62.5 mg 2 or 3 times a day. At the same time, the duration of the course for them is similar to that for adults. With a body weight of 13-25 kg, children are given 125/31.25 mg.

A separate issue is the prescription of Flemoklav to patients with reduced glomerular filtration, which is the main indicator of functional kidney failure. At the same time, there is a slowdown in the removal of the drug from the body, therefore, if necessary, use smaller doses than usual. With a glomerular filtration rate of 10-30 ml/min, adults are given 500/125 mg twice, and if it is below 10 ml/min, only once a day.

Overdose of "Flemoklav"

An overdose of a drug develops most often when its elimination from the body is impaired due to kidney problems, or during self-medication, when the patient or his relatives select the dose incorrectly. It is usually manifested by symptoms from the digestive tract (feeling of heaviness in the abdomen, nausea, vomiting, aching pain). Sometimes, when these symptoms are severe, a disturbance in the body’s water and electrolyte balances also appears.

If symptoms of overdose appear, Flemoklav should be discontinued immediately. The patient is given sorbents (activated carbon) to take. At in serious condition The patient is undergoing hemodialysis.

Video

The video talks about how to quickly cure a cold, flu or acute respiratory viral infection. Opinion of an experienced doctor.

A common drug prescribed by specialists for many infectious and inflammatory diseases bacterial etiology, is Flemoklav Solutab. When is the medicine prescribed and how to take it? Can pregnant and nursing mothers use it? How to use Flemoclav correctly?

Composition of the drug, pharmacological group and properties

The antibiotic is based on amoxicillin trihydrate. One more active substance, which is part of the medicine, is the so-called clavulanic acid. The medicine also contains auxiliary components, such as apricot flavoring, crospovidone, microcrystalline cellulose, vanillin, saccharin and magnesium stearate.

The medicine belongs to the group antibacterial drugs who have wide range impact. This drug is an antibiotic penicillin series(beta-lactamase inhibitor).

The active components of Flemoklav actively affect gram-negative and gram-positive pathogens. They destroy the integrity of the bacterial membrane cells, as a result of which their growth and reproduction decreases as the microorganisms begin to die. The antibiotic kills especially quickly.The drug is mainly excreted in the urine. It has the ability to penetrate breast milk.

Flemoklav is available in tablets that are dispersible.

The blister contains four pieces. The color of the tablets is whitish-yellowish interspersed with a brown tint. Their shape is oblong.

Tablets are available in different dosages depending on the content of amoxicillin in them - 500, 250 or 125 mg. They are placed in blisters of five pieces. Four blister packs are placed in a cardboard box.Flemoclav is also available in tablets that contain 875 mg of amoxicillin. They are packaged in blister packs of seven or five pieces.

It is recommended to store the medicine in a place that is difficult for children to reach. The drug should not be exposed to direct sunlight. The optimal temperature for storing antibiotics is no more than twenty-five degrees.The tablets are suitable for use for three years from the date of manufacture. During this period, brown dots or marbling may appear on the tablets.In pharmaceutical institutions, the drug is sold over-the-counter.

When is an antibiotic prescribed?

Flemoklav Solutab is usually prescribed for otolaryngological diseases, infections of the skin and soft tissues. Therapists prescribe medicine for infectious and inflammatory diseases of the upper and lower respiratory system. An antibiotic is also used for genitourinary diseases.

The antibiotic is used for the following diseases respiratory tract:

• Bronchitis is acute or chronic.
• Lung abscesses.
• Empyema of the pleura.
• Pneumonia.
• Obstructive pulmonary disease.

In otolaryngology, Flemoclav is used to treat the following pathologies:

• Rhinitis acute
• Sphenoiditis
• Rhinopharyngitis

The use of antibiotics is possible for diseases that affect soft fabrics and skin:

• Impetigo
• Phlegmon
• Erysipelas
• Secondary dermatitis
• Abscesses

The drug is prescribed for infectious diseases of the urinary system and kidneys. These include:

• Nephritis
• Pyelonephritis
• Cystitis
• Urethritis

Indications for the drug may include the following: pathological conditions, such as osteomyelitis, sepsis, peritonitis, as well as infectious complications after surgical interventions.

Dosage of the drug and features of use

Flemoclav Solutab is intended for internal use.The dosage of Flemoclav is determined in each case by a specialist. It depends on the age criterion, the person’s body weight, and the nature of the disease.

The official instructions for taking the drug indicate the following doses: for children over twelve years of age and adults, the dose is 875 mg per 125 mg twice a day, that is, every 12 hours or 500 mg per 125 mg three times a day (every 8 hours).In severe cases of the disease or relapses, the dose may be increased.

For a child whose weight is up to forty kilograms, the antibiotic is prescribed in a lower dosage:

• At the age of 3 months to two years with body weight up to 12 kg - 125/31.25 mg twice a day
• Up to the age of seven and weighing less than 25 kg – 125/31.25 mg three times a day
• Children under 12 years old weighing up to 37 kg – 250/62.5 mg three times a day

The dosage for children is calculated as follows: from 20 to 30 mg of medication per 1 kilogram of weight. Having calculated the daily dose of the antibiotic, it is divided into three doses.

The duration of treatment with Flemoklav depends on the severity of the disease, but should not exceed two weeks.

It is recommended to swallow the tablet whole. It needs to be washed down a large number water. Another method of administration is also allowed - dissolving the tablet in half a cup of water. To do this, throw the tablet into water and stir thoroughly. After this, the medicine is drunk. The amount of water should be at least thirty milliliters.

Special instructions regarding taking antibiotics include:

• Use Flemoklav every 8 or twelve hours, depending on daily amount taking an antibiotic.
• The drug must be taken for at least three days after the signs of the disease disappear.
• At long-term use medications need to monitor the functioning of the kidneys, liver, and blood properties.
• For patients with a history of renal failure, the dosage should be adjusted. It depends on creatinine clearance - with a reading of ten to thirty milliliters per minute, a dose of 500 mg is prescribed twice a day. If creatinine clearance is less than ten milliliters, then this dose is taken once a day.
• When using the drug by patients operating machinery, it is better to temporarily stop working.
• The condition of patients who have catheters for urine excretion requires medical supervision. This is explained by the fact that since amoxicillin is excreted primarily in the urine, its high level in it provokes precipitation medicinal substances on the catheter walls. Therefore, it is recommended for such patients frequent change catheter.
• To prevent digestive disorders, including dysbiosis, the patient is also prescribed probiotics. These include Linex, Laktovit, Bifidumbacterin, Yogurt and others.

Before using an antibiotic, it is important to familiarize yourself with its official instructions, especially with the section on drug interactions with other medications. In addition, before prescribing a medicine, the specialist must be informed about what medications the patient is taking.

Use for the treatment of pregnant women and breastfeeding

When using Flemoklav Solutaba for the treatment of pregnant women negative impact was not observed on the fetus. However, it is important to remember that in the first three months, when the fetus is forming, the use of medications should be coordinated with a leading specialist.

Usually during this period it is not recommended to take any medications. Therefore, a specialist may advise taking more safe means alternative medicine.In the second and third trimester, the doctor takes into account the risks and benefits of the antibiotic during pregnancy before prescribing Flemoklav.

The active components of the drug pass into breast milk through the blood-placental barrier. Flemoklav Solutab can be used by nursing mothers, but if a baby develops adverse reactions, breast-feeding should be stopped temporarily.

Contraindications and side effects

There are some restrictions on the use of Flemoklav. Patients who have a history of the following pathologies are not allowed to take tablets:

• Lymphocytic leukemia.
• Mononucleosis of infectious etiology.
• Kidney failure.
• The tablets are contraindicated in patients whose liver function is impaired after taking amoxicillin, and jaundice is also observed.
• Antibiotics should not be given to children weighing less than forty kilograms.
• Contraindications are also individual intolerance to the components of the drug, hypersensitivity to penicillin and cephalosporin antibiotics.

Flemoklav Solutab is prescribed with caution for liver and kidney diseases, digestive disorders, and bronchial asthma.

The antibiotic is usually well tolerated by patients. However, the development of undesirable reactions is still possible. Most common side effects are:

• Nausea
• Gagging
• Abdominal pain
• Diarrhea
• Colitis pseudomembranous
• Flatulence
• Elevated liver enzyme levels
• Skin rashes and itching
• Changing the shade of tooth enamel
• Dry mouth
• Change in taste
• Dyspepsia

Allergic reactions include morbilliform exanthema, urticaria, dermatitis (exfoliative and bullous), Stevens-Johnson syndrome, eosinophilia, hemolytic anemia, angioedema, allergic vasculitis. If anaphylactic shock occurs and untimely assistance occurs, death can occur.

Useful video - Antibiotics for colds and flu:

In rare cases, other side effects may occur:

• From the hematopoietic and coagulation systems: hemolytic anemia, thrombocytosis, thrombocytopenia, anemia, leukopenia, pancytopenia, granulocytopenia.
• From the nervous system: headache, convulsions, dizziness, anxiety, sleep disturbance, loss of consciousness, aggressiveness and irritability.
• From the digestive system: hemorrhagic colitis, intestinal candidiasis, cholestatic jaundice, hepatitis.
• From the genital and urinary organs: burning sensation and itching of the external genitalia, the appearance of discharge, interstitial nephritis.

If these adverse reactions occur, treatment with Flemoclav should be discontinued. It is necessary to contact a specialist who will prescribe symptomatic treatment to eliminate adverse reactions, prescribe medications or an antibiotic of a suitable group for the patient.

Overdose and actions for it

Cases of overdose with Flemoclav are rare. This usually happens when the rules for taking an antibiotic are violated. Signs of an overdose are nausea, diarrhea, vomiting, intoxication of the body, and convulsions. In rare cases, hemolytic disorders, renal failure, acidosis, crystalluria, and shock may occur. If the patient experiences such reactions, stop taking the medication and contact a clinic.

The first action in case of overdose should be gastric lavage. To eliminate the symptoms of overdose, the patient needs to drink activated charcoal or osmodiuretics and enterosorbent agents. It is important in such cases to maintain electrolyte and water balance in the body.

In case of overdose, specialists prescribe medications to relieve symptoms.

If the patient experiences convulsions, they are eliminated with the help of Diazepam. For severe kidney dysfunction, hemodialysis is performed.

To prevent cases of overdose, you should not determine the dose of the medicine yourself; it is better to entrust this to a specialist. IN mandatory Compliance with all doctor's instructions and the recommended dose of antibiotic is required.

Analogues of Flemoklav Solutaba

Rapiklav

Trifamox

Theraclave

Amoklan

Clavocin

Moxiclave

Ranklav

Clavunat

These drugs belong to the penicillin group of antibacterial agents. They contain, like Flemoclav Solutab, amoxicillin and clavulanic acid, and therefore have a detrimental effect on various pathogens. The indications for use of the medicine are also identical.

The advantage of these analogues may be a smaller list of contraindications and side effects.The prices for these drugs are average, about the same as for Flemoklav. It is important to note that in pharmacies you can also buy cheaper drugs that can replace Flemoklav, but when choosing them you should focus on the composition of the antibiotic - it is still better to take a medicine that combines both active components - ampicillin and clavulanic acid.If penicillin antibiotics are not suitable for the patient, then drugs of the macrolide or cephalosporin group are prescribed.