Sleeping pill Imovan - instructions for use, price, reviews and analogues. Drug interactions with other drugs
Prohibited during pregnancy
Prohibited when breastfeeding
Prohibited for children
Has restrictions for older people
Has limitations for liver problems
Has limitations for kidney problems
Imovan is a drug widely used in medicine as a hypnotic, tranquilizing and anticonvulsant. The country of origin of the drug is France. The drug is used exclusively on the recommendation of a doctor, but even in this case, for safe therapy, you must carefully read the instructions for use of Imovan.
General information about the drug
Imovan belongs to the class of hypnotic drugs, but its structure differs from barbiturates and benzodiazepines. The action of the drug is aimed at suppressing the central nervous system, therefore the medication is widely used to treat insomnia.
Repeated or long-term use The drug may cause tolerance and dependence.
In this case, when the drug is discontinued, a withdrawal state may be observed, characterized by loss of strength, nervousness and low performance.
Release form and prices for the drug, average in Russia
The medicine is available in the form of oral tablets, which are sold in pharmacies only with a doctor's prescription. They're covered film-coated, have an oval shape, white color and a line on one side. The tablets are packaged in blister packs of 10 or 20 pieces. Blisters are packed in cardboard boxes. One box contains one blister. The drug should be stored at room temperature and can be used for 3 years.
The price of Imovan varies slightly in different pharmacies and regions of Russia.
Compound
One tablet of Imovan contains 7.5 mg of the active ingredient zopicone. The drug also contains auxiliary components:
- wheat starch;
- calcium hydrogen phosphate;
- magnesium stearate;
- titanium dioxide;
- Dipromelose.
Pharmacodynamics and pharmacokinetics
The medication belongs to list No. 1 potent drugs PKKN belongs to the group of cyclopyrrolones. His pharmacological action manifests itself in the provision of sleeping pills, sedatives, muscle relaxants and anticonvulsant effect. These effects are due to a specific agonistic effect on GABA receptors, which inhibit the transmission of nervous excitation.
Among the effects of the drug are the following:
- Increased sleep duration and significant improvement in its quality.
- Reducing the time to fall asleep.
- Reduce awakenings in the middle of the night.
- Elimination of sleep disturbances in general.
In patients who suffer from insomnia, after taking the drug, there is a significant reduction in phase I sleep (drowsiness, transition from wakefulness to sleep) and prolongation of phase II (phase deep sleep). Along with this, the preservation and extension of phases III and IV is observed.
Imovan is quickly absorbed regardless of food intake. Highest concentration in the blood is achieved 1.5 hours after taking the drug. Imovan binds weakly to proteins in the blood, so the risk of interaction with other medications taken at the level of protein binding is very low. Repeated doses of the medicine do not contribute to its accumulation in the body. The half-life of the drug is 5 hours. The clearance of Imovan is predominantly metabolic.
Indications and contraindications
The medication is indicated if the patient has the following conditions:
- insomnia of a chronic, situational or transient nature;
- difficulty transitioning to sleep;
- frequent night and early awakenings;
- sleep problems due to mental disorders.
Types of night sleep disorders
The medicine is not intended for long-term use, as addiction may develop. Available absolute contraindications before taking this medicine:
- sensitivity or intolerance to individual components of the medication;
- autoimmune neuromuscular diseases, which are accompanied by rapid muscle fatigue;
- difficulty breathing;
- severe apnea;
- renal and liver failure;
- lactase deficiency.
Patients with drug and alcohol addiction The medication should be used with caution and only as prescribed by a doctor.
The use of Imovan is not recommended during pregnancy (the child may experience difficulty breathing and hypotension) and during lactation. If the drug is prescribed to women reproductive age, the doctor is obliged to warn that if you are planning a pregnancy, taking Imovan should be discontinued. Pediatric practice does not provide for the use of this drug, so the effect the drug has on children's body not researched.
Instructions for use
Imovan tablets are designed for oral administration. The course of treatment should be as short as the patient’s condition allows. As a rule, it does not last longer than four weeks, and subsequent extension of treatment is possible after consultation with a doctor.
The duration of treatment with Imovan depends on the type of insomnia for which the drug is mainly prescribed:
- For situational insomnia, the medicine is used for no more than 3 days.
- At chronic insomnia you need to follow the recommendations of your doctor.
- For transient insomnia (may be caused by short-term stress or emotional overload), you can take the drug for no more than 5 days.
The optimal dose for an adult is 7.35 mg (one tablet). Elderly people (over 65 years of age) and patients who have difficulty breathing should not be given a dose greater than 3.75 mg. The recommended dose should not be exceeded to avoid the risk of overdose. The drug should be discontinued gradually, slowly reducing the dose.
The time to take Imovan is immediately before bedtime. The medicine should be taken only once a day and not repeated if there is no effect. Caution must be exercised and used only as prescribed by a doctor for people with alcohol and drug addiction.
Special instructions when taking Imovan
Long-term use of the drug can provoke the development of psychological and physical dependence. The risk of its occurrence is especially high if the patient has anxiety state, alcoholism and uncontrolled dose increases.
Abrupt cessation of taking Imovan in this case causes withdrawal syndrome - deterioration of the patient’s condition or increased manifestation of the symptoms for which the drug was prescribed. Withdrawal symptoms are characterized by tremors, sleep disturbances, numbness in the extremities, and irritability. In this regard, the amount of medication taken should be reduced gradually.
It is important to take the drug before going to bed and rest for at least 6 hours, because if there is a long time gap between going to bed and taking the medicine, amnesia may develop.
Imovan is not intended for the treatment of depression and should not be used if the patient has such a disease, since this medication hides its symptoms, but does not cure it. When taking Imovan, you should limit activities that require concentration and attentiveness. Due to possible blurred vision, double vision and lethargy, it is not recommended to drive or engage in business activities.
Drug interactions
The drug is not compatible with alcohol, and it is undesirable to use it with caffeine.
Possible side effects and overdose
Taking the drug may cause several side effects. Among them:
An overdose of Imovan can manifest itself in such conditions as severe drowsiness and coma, depending on how much the dose was exceeded. Non-life-threatening consequences are apathetic state, drowsiness and loss of coordination.
However, the weakened condition of the patient, the presence serious illnesses, taking other drugs with similar composition and alcohol can greatly aggravate the situation. In more serious cases overdose, severe respiratory depression is observed, a persistent decrease in blood pressure, ataxia and coma.
In case of overdose, gastric lavage is possible, but it will only be effective if it is carried out immediately after taking the medicine. Therefore it is necessary to call ambulance and provide the patient inpatient treatment. If there is no help in case of an overdose, death cannot be ruled out.
Similar means
Imovan has several effective analogues. They all have a similar composition, effect, contraindications and side effects. The form of all analogues is tablets for oral administration. The most famous and effective analogues Imovana are as follows:
Latest update of the description by the manufacturer 31.07.2000
Filterable list
Active ingredient:
ATX
Pharmacological group
Nosological classification (ICD-10)
Composition and release form
1 film-coated tablet contains zopiclone 7.5 mg; in blister 5 and 20 pcs., in cardboard box 1 blister.
Pharmacological action
Pharmacological action- sedative, hypnotic.Activates GABAergic mechanisms of synaptic transmission in the brain.
Pharmacokinetics
T1/2 - 5.5-6 hours, long-term use is not accompanied by accumulation (including metabolites).
Clinical pharmacology
Possessing high degree affinity for binding sites on the GABA receptor complex in the central nervous system, quickly induces sleep with a normal phase composition; In the morning there is no drowsiness and fatigue. Renal dysfunction does not require dose reduction. Abrupt cessation of use does not cause withdrawal effects.
Indications of the drug Imovan ®
Insomnia: difficulty falling asleep, waking up at night, waking up early, secondary disorders sleep in mental disorders.
Contraindications
Hypersensitivity, decompensated respiratory failure, age up to 15 years.
Use during pregnancy and breastfeeding
Side effects
Sensation of bitter and metallic taste, nausea, irritability, depressed mood, confusion, allergic reactions(urticaria, rash); upon awakening - drowsiness, dizziness, loss of coordination (rarely).
Interaction
Reduces the concentration of trimipramine. Enhances the effect of alcohol and other central nervous system depressants.
Directions for use and doses
Inside, before bedtime - 1 tablet. within 4 weeks (no more). For patients suffering from severe and persistent insomnia, the dose can be increased to 2 tablets.
Treatment of elderly people should begin with a lower dose - 0.5 tablet. Depending on the effectiveness and tolerability, the dose may be increased in the future.
In patients with severe liver dysfunction, the recommended dose is 0.5 tablets.
Precautions
The day after taking it, you should drive vehicles and operate machinery with caution. Long-term use, like other sleeping pills, is not recommended. Must be avoided simultaneous administration with alcohol and central nervous system depressants.
Storage conditions for the drug Imovan ®
In a dry place, at a temperature not exceeding 30 °C.Keep out of the reach of children.
Shelf life of the drug Imovan ®
3 years.Do not use after the expiration date stated on the package.
Synonyms of nosological groups
| Category ICD-10 | Synonyms of diseases according to ICD-10 |
|---|---|
| G47.0 Disturbances in falling asleep and maintaining sleep [insomnia] | Insomnia |
| Insomnia, especially difficulty falling asleep | |
| Desynchronosis | |
| Long-term sleep disturbance | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| Insomnia | |
| Short-term and transient sleep disturbances | |
| Short-term and chronic sleep disorders | |
| Short or shallow sleep | |
| Sleep disturbance | |
| Sleep disturbance, especially during the falling asleep phase | |
| Sleep disorders | |
| Sleep disorders | |
| Neurotic sleep disorder | |
| Shallow, shallow sleep | |
| Shallow sleep | |
| Poor sleep quality | |
| Night awakening | |
| Night awakenings | |
| Sleep pathology | |
| Postsomnia disorder | |
| Transient insomnia | |
| Problems falling asleep | |
| Early awakening | |
| Early morning awakening | |
| Early awakenings | |
| Sleep disorder | |
| Sleep disorder | |
| Persistent insomnia | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| Difficulty falling asleep in children | |
| Difficulty falling asleep | |
| Difficulty falling asleep | |
| Persistent insomnia | |
| Deterioration of sleep | |
| Chronic insomnia | |
| Frequent night and/or early morning awakenings | |
| Frequent awakenings at night and a feeling of shallow sleep |
Instructions for the drug Imovan, contraindications and methods of use, side effects and reviews about this drug. Doctors' opinions and the opportunity to discuss on the forum.
MedicineInstructions for use
Directions for use and dosage Imovan
Treatment should be carried out as short as possible and not more than 4 weeks. Increasing the treatment period is possible after re-evaluating the patient's condition. The drug is taken before bedtime.
Duration of treatment transient insomnia- from 2 to 5 days, situational insomnia - from 2 to 3 weeks. At chronic insomnia The doctor determines the duration of the course of treatment individually.
Treatment of elderly patients, patients with impaired liver function or chronic pulmonary insufficiency start with a dose of 3.75 mg and, if necessary, increase it to 7.5 mg.
U patients with renal failure It is recommended to start treatment with a dose of 3.75 mg, despite the fact that in this pathology the accumulation of zopiclone and its metabolites was not detected.
Side effects Imovan
Most often: bitter taste in the mouth.
From the side of the central nervous system: dizziness, headache, residual drowsiness after awakening, possible anterograde amnesia; rarely - nightmares, irritability, confusion, hallucinations, aggressiveness, confusion, depressed mood, poor coordination of movements, depressive state, inappropriate behavior With possible development amnesia.
From the outside digestive system: dyspepsia, nausea, dry mouth; in isolated cases - slight increase activity of liver transaminases and/or alkaline phosphatase in the blood serum.
Allergic reactions:itchy skin, rash; extremely rarely - angioedema, anaphylactic reactions.
After stopping treatment: withdrawal syndrome, which manifests itself various symptoms such as rebound insomnia, anxiety, tremor, increased sweating, agitation, confusion, headache, trembling, tachycardia, delirium, nightmares, hallucinations, irritability; very rarely - seizures.
Almost all medications have side effects. This usually occurs when taking medications during maximum doses, when using the medicine for a long time, when taking several medications at once. Individual intolerance to a particular substance is also possible. This may harm your body, so if the medicine makes you sick side effect, you need to stop taking it and consult a specialist.
Overdose
Symptoms: varying degrees CNS depression from drowsiness to coma, depending on the amount of the drug taken. In mild cases, drowsiness, confusion, and apathy are observed. In more serious cases - ataxia, arterial hypotension, respiratory depression, coma.
An overdose does not pose a threat to life unless combined with the use of other drugs that have a depressant effect on the central nervous system (including alcohol). Other risk factors such as concomitant disease and the weakened condition of the patient can increase symptoms and even (very rarely) lead to death.
Treatment: Gastric lavage is effective only if performed soon after taking the drug. If necessary, symptomatic and supportive therapy in a hospital setting is recommended. Special attention should be given to maintaining respiratory and cardiovascular system. Hemodialysis is not very effective due to the large V d of zopiclone. Flumazenil can be used as an antidote.
An increased inhibitory effect on the central nervous system is possible with simultaneous administration of the drug Imovan ® with antipsychotics, sleeping pills, tranquilizers, sedatives, antidepressants, opioid analgesics, antiepileptic drugs, anesthetics, antihistamines With sedative effect, as well as with erythromycin.
Taking Imovan ® reduces the plasma concentration of trimipramine and its effect.
When co-administering Imovan ® with inhibitors of the CYP3A4 isoenzyme (erythromycin, clarithromycin, ketoconazole, ritonavir), the plasma concentration of zopiclone may increase.
When simultaneous administration of the drug Imovan ® with inducers of the CYP3A4 isoenzyme (including rifampicin, carbamazepine, phenobarbital, phenytoin), a decrease in the concentration of zopiclone in plasma is possible.
Very significant information that is not always taken into account when taking medications. If you take two or more drugs, they can either weaken or strengthen each other's effects. In the first case, you will not get the expected effect from the drug, and in the second, you risk getting an overdose or even poisoning.
A hypnotic drug from the cyclopyrrolones group. It has the following pharmacological properties: hypnotic, sedative, tranquilizing, anticonvulsant and muscle relaxant. These effects are associated with its action on the CNS receptors related to the macromolecular GABA complex, modulating the opening of channels for chloride ions.
Zopiclone has the ability to reduce the time to sleep and the frequency of night awakenings, increase the duration of sleep and improve the quality of sleep and awakening.
There is no addiction to the hypnotic effect of the drug during long period treatment up to 17 weeks.
Pharmacokinetics
Suction
Zopiclone is rapidly absorbed. Cmax in blood plasma is reached within 1.5-2 hours and is approximately 30 and 60 ng/ml after oral administration of 3.75 mg and 7.5 mg, respectively. Absorption of the drug does not depend on gender or food intake.
Distribution
The binding to plasma proteins is approximately 45%.
Metabolism
After repeated prescriptions, accumulation of zopiclone and its metabolites does not occur.
Interindividual differences are insignificant.
The main metabolites are the N-oxide derivative (pharmacologically active) and the N-desmethyl metabolite (pharmacologically inactive). T 1/2 is approximately 4.5 and 7.4 hours, respectively.
Removal
At recommended doses, half-life of unchanged zopiclone is approximately 5 hours. Zopiclone is excreted in the urine (approximately 80%), mainly in the form of metabolites; approximately 16% is excreted in feces.
Pharmacokinetics in special clinical situations
In elderly patients, despite a slight decrease in metabolism in the liver and an extension of T1/2 to approximately 7 hours, no accumulation of the drug in plasma was detected even with repeated administration.
In patients with renal failure, accumulation of zopiclone or its metabolites was not detected even after long-term use.
In patients with liver cirrhosis, the clearance of zopiclone is reduced by approximately 40%, consistent with a decrease in dimethylation.
Release form
Film-coated tablets white, oval, with a notch on one side.
Excipients: wheat starch - 60 mg, calcium hydrogen phosphate dihydrate - 60 mg, lactose monohydrate - 31.575 mg, sodium carboxymethyl starch (type A) - 4.95 mg, magnesium stearate - 0.975 mg.
Shell composition*: hypromellose - 4.95 mg, titanium dioxide (E171) - 1.65 mg, macrogol 6000 - 1.65 mg.
* - a ready-made mixture can be used to coat the tablet "Opadry OY-S-38906" - 8.25 mg (composition of "Opadry OY-S-38906": hypromellose - 60%, titanium dioxide (E171) - 20%, macrogol 6000 - 20%).
10 pcs. - blisters (2) - cardboard packs.
20 pcs. - blisters (1) - cardboard packs.
Dosage
Treatment should be carried out as short as possible and not more than 4 weeks. Increasing the treatment period is possible after re-evaluating the patient's condition. The drug is taken before bedtime.
The duration of treatment for transient insomnia is from 2 to 5 days, situational insomnia is from 2 to 3 weeks. For chronic insomnia, the doctor determines the duration of the course of treatment individually.
Treatment of elderly patients, patients with impaired liver function or chronic pulmonary failure begins with a dose of 3.75 mg and, if necessary, increases it to 7.5 mg.
Overdose
Symptoms: varying degrees of central nervous system depression from drowsiness to coma, depending on the amount of the drug taken. In mild cases, drowsiness, confusion, and apathy are observed. In more serious cases - ataxia, arterial hypotension, respiratory depression, coma.
An overdose does not pose a threat to life unless combined with the use of other drugs that have a depressant effect on the central nervous system (including alcohol). Other risk factors, such as concomitant illness and debilitated condition of the patient, can increase symptoms and even (very rarely) lead to death.
Treatment: Gastric lavage is only effective if performed soon after taking the drug. If necessary, symptomatic and supportive therapy in a hospital setting is recommended. Particular attention should be paid to maintaining the activity of the respiratory and cardiovascular systems. Hemodialysis is not very effective due to the large Vd of zopiclone. Flumazenil can be used as an antidote.
Interaction
An increased inhibitory effect on the central nervous system is possible with the simultaneous administration of Imovan ® with antipsychotics, hypnotics, tranquilizers, sedatives, antidepressants, opioid analgesics, antiepileptic drugs, anesthetics, antihistamines with a sedative effect, as well as erythromycin.
Taking Imovan ® reduces the plasma concentration of trimipramine and its effect.
When co-administering Imovan ® with inhibitors of the CYP3A4 isoenzyme (erythromycin, clarithromycin, ketoconazole, ritonavir), the plasma concentration of zopiclone may increase.
When simultaneous administration of the drug Imovan ® with inducers of the CYP3A4 isoenzyme (including rifampicin, carbamazepine, phenobarbital, phenytoin), a decrease in the concentration of zopiclone in plasma is possible.
Side effects
Most common: bitter taste in the mouth.
From the side of the central nervous system: dizziness, headache, residual drowsiness after waking up, possible anterograde amnesia; rarely - nightmares, irritability, confusion, hallucinations, aggressiveness, confusion, depressed mood, impaired coordination of movements, depression, inappropriate behavior with the possible development of amnesia.
From the digestive system: dyspepsia, nausea, dry mouth; in isolated cases - a slight increase in the activity of liver transaminases and/or alkaline phosphatase in the blood serum.
Allergic reactions: skin itching, rash; extremely rarely - angioedema, anaphylactic reactions.
After cessation of treatment: withdrawal syndrome, which is manifested by various symptoms, such as rebound insomnia, anxiety, tremor, increased sweating, agitation, confusion, headache, trembling, tachycardia, delirium, nightmares, hallucinations, irritability; very rarely - seizures.
Indications
Treatment of transient, situational and chronic insomnia in adults (including difficulty falling asleep, nighttime and early awakenings).
Contraindications
- myasthenia gravis;
- severe respiratory failure;
- severe liver failure;
- sleep apnea syndrome;
- age under 18 years;
- hypersensitivity to the components of the drug.
Features of application
Use during pregnancy and breastfeeding
It is not recommended to use the drug during pregnancy and lactation (breastfeeding).Use for liver dysfunction
Treatment of patients with impaired liver function begins with a dose of 3.75 mg and, if necessary, increases it to 7.5 mg.
Use is contraindicated in severe liver failure.
Use for renal impairment
Use in elderly patients
Treatment of elderly patients begins with a dose of 3.75 mg and, if necessary, increases it to 7.5 mg.Special instructions
When prescribing the drug Imovan ®, it is necessary to remember that although the risk is minimal, the development of addiction to zopiclone and its abuse cannot be absolutely excluded. The risk of dependence or abuse arises in cases of violation of the dose and duration of treatment; alcohol abuse and/or medicines; taken with alcohol or other psychotropic drugs.
The risk of rebound insomnia and withdrawal symptoms following abrupt cessation of zopiclone cannot be excluded, especially after long-term treatment. Therefore, it is recommended to gradually reduce the dose of Imovan and notify the patient about this.
Anterograde amnesia may develop, especially when sleep is interrupted or after a significant period of time between taking the drug and going to bed. To reduce the risk of anterograde amnesia, you must take the tablet immediately before bed; Ensure sleep duration is at least 6 hours.
The drug is not indicated for the treatment of depression and may even mask its symptoms.
Use in pediatrics
A safe and effective dose of Imovan ® in children and adolescents under 18 years of age has not been established.
Impact on the ability to drive vehicles and operate machinery
Because of pharmacological properties Zopiclone may impair driving ability vehicles and working with mechanisms, therefore during the treatment period the patient should refrain from similar types activities.
In this article you can find instructions for use medicinal product Imovan. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of the sleeping pill Imovan in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Imovan in the presence of existing structural analogues. Used to treat insomnia and difficulty falling asleep in adults, children, and during pregnancy and lactation. Composition and interaction of the drug with alcohol.
Imovan - sleeping pill from the group of cyclopyrrolones. It has the following pharmacological properties: hypnotic, sedative, tranquilizing, anticonvulsant and muscle relaxant. These effects are associated with its action on the CNS receptors related to the macromolecular GABA complex, modulating the opening of channels for chloride ions.
Zopiclone (the active ingredient of the drug Imovan) has the property of reducing the time before falling asleep and the frequency of night awakenings, increasing the duration of sleep and improving the quality of sleep and awakening.
There is no addiction to the hypnotic effect of the drug during a long period of treatment, up to 17 weeks.
Compound
Zopiclone + excipients.
Pharmacokinetics
Imovan is quickly absorbed. Absorption of the drug does not depend on gender or food intake. The binding to plasma proteins is approximately 45%. After repeated prescriptions, accumulation of zopiclone and its metabolites does not occur. Interindividual differences are insignificant. The main metabolites are the N-oxide derivative (pharmacologically active) and the N-desmethyl metabolite (pharmacologically inactive). Zopiclone is excreted in the urine (approximately 80%), mainly in the form of metabolites; approximately 16% is excreted in the feces.
In elderly patients, despite a slight decrease in liver metabolism and an extension of the half-life to approximately 7 hours, no accumulation of the drug in plasma was detected even with repeated administration.
Indications
- treatment of transient, situational and chronic insomnia in adults (including difficulties falling asleep, nighttime and early awakenings).
Release forms
Film-coated tablets 7.5 mg.
Instructions for use and effective dose
Treatment should be carried out as short as possible and not more than 4 weeks. Increasing the treatment period is possible after re-evaluating the patient's condition. The drug is taken before bedtime.
The duration of treatment for transient insomnia is from 2 to 5 days, situational insomnia is from 2 to 3 weeks. For chronic insomnia, the doctor determines the duration of the course of treatment individually.
Treatment of elderly patients, patients with impaired liver function or chronic pulmonary failure begins with a dose of 3.75 mg and, if necessary, increases it to 7.5 mg.
Side effect
- bitter taste in the mouth;
- dizziness;
- headache;
- residual drowsiness after waking up;
- possible anterograde amnesia;
- nightmares;
- irritability;
- confusion;
- hallucinations;
- aggressiveness;
- confusion;
- depressed mood;
- impaired coordination of movements;
- depression;
- inappropriate behavior with the possible development of amnesia;
- dyspepsia;
- nausea;
- dry mouth;
- skin itching;
- rash;
- angioedema;
- anaphylactic reactions;
- withdrawal syndrome, which is manifested by various symptoms, such as rebound insomnia, anxiety, tremor, excessive sweating, agitation, confusion, headache, trembling, tachycardia, delirium, nightmares, hallucinations, irritability;
- seizures.
Contraindications
- myasthenia gravis;
- severe respiratory failure;
- severe liver failure;
- sleep apnea syndrome;
- age under 18 years;
- hypersensitivity to the components of the drug.
Use during pregnancy and breastfeeding
Use in children
Contraindicated in children and adolescents under 18 years of age.
Use in elderly patients
Treatment of elderly patients begins with a dose of 3.75 mg and, if necessary, increases it to 7.5 mg.
When prescribing the drug Imovan, it is necessary to remember that although the risk is minimal, the development of addiction to zopiclone and its abuse cannot be absolutely ruled out. The risk of dependence or abuse arises in cases of violation of the dose and duration of treatment; alcohol and/or drug abuse; taken with alcohol or other psychotropic drugs.
The risk of rebound insomnia and withdrawal syndrome after abrupt cessation of zopiclone cannot be excluded, especially after long-term treatment. Therefore, it is recommended to gradually reduce the dose of Imovan and notify the patient about this.
Anterograde amnesia may develop, especially when sleep is interrupted or after a significant period of time between taking the drug and going to bed. To reduce the risk of anterograde amnesia, you must take the tablet immediately before bed; Ensure sleep duration is at least 6 hours.
The drug is not indicated for the treatment of depression and may even mask its symptoms.
Dispensed by prescription.
Impact on the ability to drive vehicles and operate machinery
Due to its pharmacological properties, zopiclone can impair the ability to drive vehicles and operate machinery, so during the treatment period the patient should refrain from such activities.
An increased depressant effect on the central nervous system is possible with the simultaneous administration of Imovan with antipsychotics, hypnotics, tranquilizers, sedatives, antidepressants, opioid analgesics, antiepileptic drugs, anesthetics, antihistamines with a sedative effect, as well as erythromycin.
Taking Imovan reduces the plasma concentration of trimipramine and its effect.
When Imovan is co-administered with inhibitors of the CYP3A4 isoenzyme (erythromycin, clarithromycin, ketoconazole, ritonavir), the plasma concentration of zopiclone may increase.
When Imovan is co-administered with inducers of the CYP3A4 isoenzyme (including rifampicin, carbamazepine, phenobarbital, phenytoin), the plasma concentration of zopiclone may decrease.
Analogues of the drug Imovan
Structural analogues according to active substance:
- Zopiclone;
- Piklodorm;
- Relaxon;
- Somnol;
- Thorson.
Analogues pharmacological group(hypnotics):
- Andante;
- Berlidorm 5;
- Bromized;
- Heminevrine;
- Hypnogen;
- Donormil;
- Dormicum;
- Zaleplon;
- Zolpidem;
- Zolsana;
- Ivadal;
- Melaxen;
- Mälarena;
- Melatonin;
- Nitrazadone;
- Nitrazepam;
- Nitram;
- Nitrest;
- Nitrosan;
- Oniria;
- Radedorm 5;
- Reladorm;
- Reslip;
- Rohypnol;
- Sanwal;
- Signopam;
- Snovitel;
- Phenobarbital;
- Flormidal;
- Circadin;
- Estazolam;
- Eunoctine.
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
