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Captopril blood pressure tablets: how to take correctly for hypertension and other cardiovascular diseases? Antihypertensive drug Captopril: instructions for use, price, reviews, analogues.

Active ingredient stands Captopril . Additional substances: lactose, anhydrous colloidal silicon dioxide, corn starch, hydrogenated castor oil.

Release form

Captopril is available in tablet form. The dosage depends on the manufacturer. Acceptable dosages: 12.5, 25, 50 and 100 mg. The tablets are packaged in blisters of 10 pieces. Each cardboard pack contains 2 blisters and instructions from the manufacturer.

Pharmacological action

The medicine provides hypotensive effect . The active substance inhibits angiotensin-converting enzyme, which prevents the transition of angiotensin I to form II. It is angiotensin II that is the basic component of the renin-angiotensin system, which has a pronounced vasoconstrictor effect. Due to a decrease in the level of angiotensin II, a decrease in production and due to the accumulation of the vasodilator substance bradykinin, a hypotensive effect is achieved.

The medication reduces the overall resistance of blood vessels to blood flow, reduces the level of afterload and pressure in the pulmonary circulation. Blood pressure medications may additionally lower aldosterone levels in the adrenal glands.

Pharmacodynamics and pharmacokinetics

About 75% of the active substance is quickly absorbed from digestive system. Eating can reduce absorption by 30-40%. The maximum level of the active substance in the blood is recorded after 30-90 minutes. The active substance binds to albumin by 25-30%.

Captopril is excreted in milk during lactation. carried out in hepatic system. Metabolites do not have pharmacological activity. 95% of the drug is excreted through the renal system, almost half - in its original form, the rest - in the form of metabolites. In case of severe kidney pathology, an effect is observed cumulation (accumulations).

Indications for use of Captopril

What are Captopril tablets for? The medication is used mainly for relief hypertensive crisis , reduction.

Main indications for the use of Captopril

renal hypertension ;
essential hypertension (increase in blood pressure of unknown etiology);
malignant (with resistance to other medications).

What is Captopril Akos used for? Indications for use Captopril Akos

diabetic nephropathy in patients with (type 1);
left ventricular dysfunction in patients who have undergone and achieved a clinically stable condition.

Contraindications

Captopril tablets for blood pressure are widely used in cardiological practice, but have certain contraindications for use:

narrowing of the aorta;
primary hyperaldosteronism ;
narrowing of the mitral valve;
condition after kidney transplant;
gestation;
renal artery stenosis ;
tendency to form edema;
myocardiopathy ;

IN pediatric practice The medication can only be prescribed after reaching 14 years of age. Patients are advised to refrain from work that requires concentration.

Side effects

From the outside nervous system The following side effects may occur:

paresthesia;
asthenia;
fatigue.

Cardiovascular system:

rapid heartbeat;
orthostatic hypotension.

Digestive tract:

cholestasis;
stool disorders (or);
epigastric pain;
violation of taste perception;
nausea;
level up ;
increase in ALT and AST.

Hematopoietic system:

decrease in number;
anemia ;
neutropenia;
agranulocytosis (in the presence of autoimmune pathology).

Metabolism:

acidosis;
increasing K+ levels in the body.

Urinary system:

disorders of the kidneys;
detection of protein in urine.

In some cases, a dry, nonproductive cough is recorded. Possible:

bronchospasm;
presence of antinuclear antibodies;
lymphadenopathy ;
serum sickness .

When registering other negative reactions A doctor's consultation and temporary self-discontinuation of the drug Captopril are required.

Instructions for use (Method and dosage)

The tablets are intended for oral administration. The medicine quickly reduces blood pressure. Only your doctor can prescribe Captopril tablets. Instructions for use during hypertensive crises: a 25 mg tablet is placed under the tongue, which provides a faster hypotensive effect. Instructions for use Captopril Akos with renovascular form of hypertension : 12.5 mg three times a day. The effectiveness of the drug increases when taken on an empty stomach.

How to take the medicine for heart failure: three times a day, 12.5-25 mg. The maximum daily dosage is 150 mg.

At what blood pressure should I take Captopril? The drug belongs to the group of “first aid” medications and is recommended for use in in case of emergency, when during treatment standard scheme There was an increase in blood pressure to high levels due to stress and physical activity.

Overdose

If you take the pills incorrectly, an overdose can occur, which is manifested by a pronounced decrease in blood pressure. The patient's condition may become more complicated thromboembolism , myocardial infarction.

It is recommended to place the patient in a horizontal position, elevate lower limbs, try to restore blood pressure by intravenous infusion of saline solution. Peritoneal dialysis does not give the expected effect. There is a positive trend in the background.

Interaction

Together with the use of cytostatics and immunosuppressants, it can develop leukopenia . Hyperkalemia may develop with simultaneous therapy with potassium-sparing diuretics:

Amiloride;
Triamterene .

During treatment, anemia may develop due to decreased activity. IN medical literature Cases of diagnosing leukopenia associated with additive bone marrow hematopoiesis have been described. may increase the severity of hematological effects. can reduce the hypotensive effect of Captopril. The medication can increase concentration. More often drug interactions manifests itself in patients with severe pathology of the renal system. Captopril is not contraindicated.

Terms of sale

Storage conditions

Best before date

Special instructions

Which is better Captopril or Kapoten ? These two drugs are absolutely identical, because active substance In them, the INN is Captopril. The main difference between Capoten and Captopril is in the manufacturer.

During treatment, a false positive reaction may be recorded when determining acetone in the urine. In pediatric practice, the medication can be used in the absence of the effect of other antihypertensive drugs.

Analogues of Captopril

Level 4 ATX code matches:

Structural analogues of Captopril:

Alkadil.

Captopril and alcohol

Alcohol can enhance the hypotensive effect of the medication. There is a joint negative impact on the functioning of the hepatic system.

Reviews about Captopril

This is one of the most discussed antihypertensive drugs on the Internet. Many patients share and celebrate their many years of experience with Captopril treatment high efficiency in emergency cases, when regular daily therapy does not help and the pressure remains at high levels.

There are reviews about Captopril, among which quite often a side effect is described, such as, which is characteristic of all medications of the ACEI group. In general, patient reviews of Captopril are positive.

Captopril price, where to buy

Captopril is considered the most affordable antihypertensive drug, which can be found in home medicine cabinet every hypertensive person. The cost of the medication depends on the dosage, manufacturer and region of sales. The price of Captopril in Russia varies in the range of 20-140 rubles (Captopril Akos - 20 rubles, Captopril Sandoz - 140 rubles).

Online pharmacies in Russia Russia
Online pharmacies in Ukraine Ukraine
Online pharmacies in Kazakhstan Kazakhstan

WER.RU

Captopril Sandoz tablets 25 mg 40 pcs. Sandoz [Sandoz]

Captopril tablets 25 mg. 20 pcs. Sandoz [Sandoz]

Captopril tablets 50 mg 20 pcsPharmacor Production

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Captopril-akos 25 mg 40 tablets SYNTHESIS

Captopril 50 mg 20 tablets Pranapharm

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Captopril 25 mg 20 tablets Sintez OJSC

Captopril 25 mg 40 tablets Ozone LLC

Nowadays, there are quite a lot of different medications that help cope with certain problems.

For each disease, there are more than 10 different medications that have completely different effects on the body and help in a given situation.

Each person is individual, and the selection of medications should be exactly the same. Therefore, you should take any remedy only after visiting a doctor. In such cases, the dosage and the drug itself will be selected correctly, especially if it concerns tablets that reduce or increase.

These medications can be classified as such. This medicine has been used by doctors for a long time and is often prescribed to patients who have difficulties with blood pressure. So what is Captopril for, and how should it be taken?

Captopril acts as a stabilizing and blood pressure lowering agent, which in its mechanism is related to competitive.

The drug itself is an inhibitor that is prescribed to patients with severe and other diseases that occur against the background of unstable blood pressure.

This remedy quickly helps to reduce the rate of change in angiotensin 1 and its conversion to the 2nd form. This medicine causes a vasoconstrictor effect by stimulating aldosterone in the cortex.

The drug can be taken as permanent remedy for patients with high blood pressure or cardiac instability. However, the appointment is made only by the doctor after full examination sick.

Continuous reception of this medicine does not allow bradykinin to decompose, while creating it, which guarantees excellent resistance in absolutely all vessels of the body.

The drug can help reduce and also prevent an increase in heart failure and improve blood circulation, reduce platelet aggregation.

Medicine Captopril: what does it help with?

Captopril has proven itself in the fight against heart disease and is widely used to reduce the load on the heart. Due to this, the drug is used in arterial hypertensive therapy, as well as for cardiac weakness and diabetic nephropathy.

The drug is mainly prescribed to people for the following symptoms and diseases:

a form of coronary heart disease and unstable functioning of the left ventricle, but only in cases where the patient has stable dynamics of the disease;
complex treatment for heart failure;
cardiomyopathy various types, but at the same time you need to correctly and accurately select the required dosage for each person individually.

In any case, Captopril has been used by many doctors for quite a long time, because the medicine has been tested for a long time clinical trials and showed excellent results in the fight against hypertension and heart failure. Thanks to this, we can safely say that the remedy is necessary for most patients with various forms hypertension.

If necessary, tablets are also taken for other diseases in combination with other drugs. This complex is prescribed only by the attending physician based on the patient’s individual characteristics.

Contraindications

Captopril should not be taken; it is also contraindicated for women during planning, at any stage of gestation and when breastfeeding.

Captopril is contraindicated in the following diseases and disorders:

liver diseases and dysfunctions;
renal artery stenosis;
last stage of left ventricular failure;
rehabilitation period after liver transplantation;
allergies or increased sensitivity to the components of the drug.

With the above diseases and disorders, this drug is strictly prohibited for any person. Taking Captopril tablets must be fully approved by your doctor.

At wrong method treatment and non-compliance with the instructions, the medicine can worsen the patient’s condition and reduce his blood pressure. This will lead to severe diseases and consequences.

Instructions for use

Tablets are taken only after a doctor’s prescription and after a complete examination of the patient. It is available in tablets - 40 pieces of 25 mg each, which must be taken orally. For better effect the tablet is placed, which increases the absorption of beneficial elements and substances.

This leads to a rapid decrease in blood pressure and its normalization. In any case, when using Captopril, you should consult your doctor and only then start taking these tablets.

Captopril tablets

In order to treat persistent high blood pressure, the drug is prescribed at an initial dose of 12.5 mg 3 times a day. If the result is bad, then the volume can be increased over time with an interval of 1-3 weeks. Upon reaching optimal effect the dose can be reduced.

When flowing calmly arterial hypertension Usually a maintenance dose of 37.5 mg per day is taken. The maximum intake in such cases may be 50 mg 2 times a day. At maximum dose may be 50 mg 3 times daily.

The limit dose in 24 hours for any person can be no more than 150 mg.

It is most effective to take the tablet on an empty stomach. If there is a need for a rapid hypotensive effect, then it is necessary to take the medicine in a dose of 25 mg, placing the tablet under the tongue.

This will speed up the process of lowering blood pressure several times and quickly improve the patient’s well-being. For heart weakness, tablets are prescribed if they do not cause positive effect. Minimum dose is 6.25 mg 2 times a day, which can be increased over time over 2 weeks.

The maintenance dose is 25 mg 2-3 times a day. The maximum dose for any patient can be 150 mg per day. For those suffering from heart failure and hypertension, the drug is prescribed on an individual basis. Most often, you need to start taking it with 6.25 mg per day.

It is necessary to increase the intake slowly, reaching a maximum result of 150 mg per day.

If blood pressure is sufficiently high, older people are prescribed additional drugs that are combined with Captopril.

This joint course may continue to be accepted long time, it all depends on the progress of the disease and the patient’s condition. This drug applies, it must be taken in extremely urgent cases.

If the patient’s blood pressure has risen above the norm, which was determined by the doctor, then the tablet can be taken earlier than written in the instructions, but taking more than the prescribed norm is not recommended.

Side effects

According to the instructions, of this product has its side effects.

First of all, these are redness of the face and pallor, slight irritation on the hands and other areas of the skin, insomnia, hair loss, drowsiness, and vomiting.

IN in rare cases Dermatological rash, impaired renal function, stomach discomfort, and dry mouth may appear. In very rare cases, there is a change or loss of taste, profuse taste, and blurred vision.

If the medication causes severe negative reactions, then you should stop taking it and consult your doctor as soon as possible.

Due to the fact that the drug can cause dizziness and dizziness, you should avoid dangerous species classes and work.

Video on the topic

Video review of drugs Capoten and Captopril:

Captopril is an ACE inhibitor that has an antihypertensive effect.

Release form and composition

Dosage form Captopril - tablets (10 pcs. in blister packs, 1, 2, 3, 4, 5 or 10 packs in a cardboard box; in polymer cans 20, 30 or 40 pcs., 1 can in a cardboard box ).

The active ingredient of the drug is captopril; 1 tablet may contain 12.5, 25 or 50 mg.

Excipients: talc, corn starch, lactose and magnesium stearate.

Indications for use

Arterial hypertension (including renovascular);
Chronic heart failure (as part of combination therapy);
Left ventricular dysfunction after suffered a heart attack myocardium, subject to the patient’s clinically stable condition;
Diabetic nephropathy due to diabetes mellitus Type I (with albuminuria more than 30 mg per day).

Contraindications

Arterial hypotension;
Mitral stenosis, aortic stenosis and other pathologies that impede the outflow of blood from the left ventricle of the heart;
History of angioedema (including hereditary), incl. developed after the use of other ACE inhibitors;
Severe liver dysfunction;
Severe renal dysfunction, hyperkalemia, azotemia, bilateral stenosis renal arteries or stenosis of a single kidney with progressive azotemia, primary hyperaldosteronism, condition after kidney transplantation;
Cardiogenic shock;
Pregnancy;
Breastfeeding;
Age under 18 years (due to the lack of data on the safety and effectiveness of use in this age category of patients);
Hypersensitivity to captopril, any auxiliary component of the drug or other ACE inhibitors.

Elderly people, patients on hemodialysis, people on a sodium-restricted diet, as well as patients diagnosed with severe autoimmune diseases (including systemic lupus erythematosus and scleroderma), cerebral ischemia, coronary artery disease should be under constant supervision during the treatment period. heart, diabetes mellitus, bone depression cerebral circulation and conditions accompanied by a decrease in blood volume (including diarrhea and/or vomiting).

Directions for use and dosage

Captopril should be taken orally one hour before meals.

Treatment of arterial hypertension (AH) begins with a dose of 25 mg 2 times a day. If therapeutic effect is not enough, it is gradually (at intervals of 2-4 weeks) increased. Maximum permissible daily dose for severe hypertension – 150 mg (50 mg 3 times a day).

For chronic heart failure, Captopril is prescribed in cases where the previous use of diuretics could not provide the desired effect. Treatment begins with a dose of 6.25 mg 2-3 times a day. Subsequently, it is gradually (at minimum intervals of 2 weeks) increased to 25 mg 2-3 times a day. If in this case the therapeutic effect is not enough, a further gradual increase to the maximum permissible daily dose of 150 mg (50 mg 3 times a day) is possible.

Patients with moderate degree impaired renal function (with CC of at least 30 ml/minute/1.73 m2), the drug can be used in a daily dose of 75-100 mg. With more pronounced violations renal function, Captopril should be started with a dose of 12.5-25 mg/day. If necessary, further increases in the dose are possible, but at fairly long intervals. In this case, the maximum dose should be less than the usual daily dose for patients without renal impairment.

The dose of Captopril for older people is selected individually. Treatment begins with 6.25 mg 2 times a day and, if possible, try to maintain it at this level.

Side effects

Cardiovascular system: marked decrease in blood pressure (BP), peripheral edema, orthostatic hypotension, tachycardia;
Urinary system: proteinuria, functional disorders kidneys (increased levels of creatinine and urea in the blood);
Central nervous system: paresthesia, ataxia, drowsiness, headache, blurred vision, asthenia, dizziness, feeling tired;
Digestive system: dry mouth, loss of appetite, stomatitis, disorder taste sensations, nausea; rarely – abdominal pain, diarrhea, hyperbilirubinemia, increased activity of liver transaminases, hepatitis;
Respiratory system: dry cough (in most cases disappears after discontinuation of Captopril), bronchospasm, pulmonary edema;
Hematopoietic system: rarely - anemia, agranulocytosis, neutropenia, thrombocytopenia;
Dermatological reactions: increased photosensitivity, itching, rash (usually maculopapular, less often bullous and vesicular);
Allergic and immunopathological reactions: lymphadenopathy, serum sickness, angioedema of the extremities, face, tongue, mucous membranes, lips, pharynx and/or larynx; rarely - intestinal edema, the appearance of antinuclear antibodies in the blood;
Laboratory indicators: hyponatremia, hyperkalemia, acidosis. Known individual cases the development of hypoglycemia in patients with diabetes mellitus receiving oral hypoglycemic drugs and insulin;
Other: paresthesia.

Symptoms of captopril overdose: pronounced decrease in blood pressure, up to collapse, acute disorder cerebrovascular accident, myocardial infarction, thromboembolic complications. In the event that the patient has taken too much high dose drug, you should lay it in a horizontal position and slightly raise your lower limbs. Treatment of overdose is symptomatic. Measures aimed at restoring blood pressure are prescribed. If necessary, hemodialysis is performed. Peritoneal dialysis is ineffective.

Special instructions

Before prescribing the drug, it is necessary to conduct an examination of kidney function and then monitor it throughout the entire period of treatment.

Captopril is prescribed with extreme caution to patients receiving immunosuppressants, procainamide or allopurinol, especially if they have impaired renal function, as well as to patients with systemic vasculitis And diffuse diseases connective tissue. Before starting treatment, every 2 weeks for the first 3 months and periodically throughout the subsequent period of therapy, it is necessary to monitor the peripheral blood picture.

If the effect of using Captopril alone is insufficient, additional doses may be prescribed loop diuretics, but not thiazide ones!

The drug should be used with caution in patients with a history of kidney disease, since they have a high risk of developing proteinuria. During the first 9 months of treatment, they need to monitor the concentration of protein in their urine monthly. If the level exceeds 1 g/day, the doctor must decide whether continued use of Captopril is appropriate.

Probability of development arterial hypotension can be reduced if diuretics are discontinued 4-7 days before starting Captopril or their dose is significantly reduced.

After taking the drug, symptomatic arterial hypotension may develop. In this case, you should take a horizontal position with your legs raised.

If the level of creatinine or urea in the blood increases in patients with renal artery stenosis, the dose of the drug is reduced, and in some cases it is discontinued altogether.

When prescribing hemodialysis to patients receiving Captopril, dialysis membranes with high permeability should not be used, because the risk of developing anaphylactoid reactions increases.

During development angioedema Captopril is discontinued and careful medical examination. If there is swelling of the face, special treatment, as a rule, is not required, can be prescribed to reduce symptoms antihistamines. If the swelling extends to the larynx, pharynx and tongue or there is a threat of obstruction respiratory tract, immediate subcutaneous administration of epinephrine is indicated.

Captopril may cause a false-positive urine test for acetone.

During treatment with this drug, you should refrain from engaging in potentially hazardous activities, including driving a car.

Captopril is contraindicated during pregnancy. It should be borne in mind that when taken in the second and third trimesters, the drug may cause serious violations development and even death of the fetus.

If pregnancy is confirmed during treatment, the drug should be discontinued immediately.

Drug interactions

The hypotensive effect of captopril is enhanced by vasodilators and diuretics, pergolide, minoxidil, nitroprusside, and reduced by estrogens, erythropoietins, indomethacin and, presumably, other non-steroidal anti-inflammatory drugs.

The antihypertensive effect of the drug may be slowed down by clonidine.

When used simultaneously with lithium salts, Captopril may increase the concentration of lithium in the blood serum.

At combined use with potassium preparations, potassium-sparing diuretics, salt substitutes and dietary supplements containing potassium, trimethoprim there is a risk of developing hyperkalemia (especially in patients with impaired renal function); with insulin and oral hypoglycemic agents – hypoglycemia; with allopurinol and procainamide – Stevens-Johnson syndrome and/or neutropenia; with immunosuppressants and cytostatics – hematological disorders; with interleukin-3 – arterial hypotension; with anesthesia – severe arterial hypotension; with procainamide – leukopenia; with chlorpromazine – orthostatic hypotension; with azathioprine – anemia; with interferon alpha-2a or interferon beta – severe granulocytopenia.

When taking captopril, a false-positive urine test reaction to acetone may occur.

There are reports of the development of a symptom complex, including nausea, vomiting, facial flushing and decreased blood pressure, in patients who simultaneously took gold preparations (sodium aurothiomalate) with Captopril.

The renal clearance of captopril is reduced with the use of probenecid.

Orlistat may significantly reduce the effectiveness of the drug, which may lead to increased blood pressure and hypertensive crisis. There is a known case of cerebral hemorrhage.

Captopril may increase the concentration of digoxin in the blood plasma, the risk is especially high in patients with impaired renal function.

The bioavailability of captopril is reduced by magnesium carbonate, magnesium hydroxide and aluminum hydroxide.

Terms and conditions of storage

Store at temperatures up to 30 ºС in a dry place, out of reach of children.

Shelf life – 3 years.

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Captopril – remedy, used when necessary to reduce blood pressure and to prevent other diseases. The drug is available in the form of tablets, which contain “captopril”, and the medicine was named after this substance. Captopril helps lower blood pressure and also reduces the strain on the heart.

The medicine must be used to prevent diseases such as:

Arterial hypertension. If this disease occurs, tablets should be taken as additional treatment, together with other drugs;
Heart failure;
Impaired functioning of the left ventricle (in the presence of myocardial infarction);
Occurring in the presence of diabetes, diabetic nephropathy;
Autoimmune nephropathies (scleroderma, lupus erythematosus);
Cardiomyopathy.

Benefits of the drug

This drug is one of the best for the treatment of hypertension and other types of diseases. The main advantage of the tablets is that it significantly reduces the risk of death from cardiovascular diseases. Also, one of the advantages of the drug is its safety. People can even take captopril old age. The drug does not affect the male genital organs. Thanks to Captopril, the incidence of cancer is reduced.
The drug is much cheaper than its analogues, but at the same time it has good quality. Efficacy of the drug. Captopril as a medicine was prescribed to treat hypertension and heart failure in the 90s of the 20th century. Many people have noted it as an excellent drug when it is necessary to lower blood pressure almost immediately.

There are many new treatments available to treat the same conditions that Captopril treats. However, most studies have shown that medicine Captopril lowers blood pressure and prevents mortality several times better than the newly invented drugs. The drug copes well with treatment, providing high quality, but also has a low cost.

Treatment and effect

This drug has a noticeable effect when taken regularly. It significantly reduces the pressure in the arteries and keeps it at values not exceeding the norm. Usually, as soon as about an hour passes after taking the drug, Captopril significantly reduces blood pressure. But to consolidate this result, you need to take the drug for a month. If necessary, reduce the load on the heart, the drug provides required action, due to vasodilation.

With the help of Captopril, endurance and tolerance of any stress increases in people who have suffered from heart failure or suffered a heart attack. It is also worth noting that the drug can increase renal blood flow. This property is used to treat diabetic nephropathy.

Reviews

Almost 100% of reviews about the drug are positive. This is explained high quality and the effectiveness of the medicine for the diseases that it eliminates. Reviews contain information about the speed and quality of blood pressure reduction with this drug.

The drug is an indispensable medicine for blood pressure. Does not exclude the remedy and negative reviews. They are associated with the appearance side effects, due to which people were forced to stop taking the medicine.

Directions for use and dosage

It should be consumed about an hour before meals, washed down a large number liquids. The medicine has an individual dosage. When taking the drug, it is necessary to constantly monitor the body's reaction in order to increase or decrease the dose. The maximum dose per day is 290 mg. If this dose is exceeded, the effect of the drug will not increase, but side effects may appear.

The drug is usually started with a dose of 24 mg per day. Depending on the change in the person’s condition, after a couple of weeks you can increase or not change the dosage. If a person suffers from hypertension, the dosage of the drug is usually 24 mg 2 times a day. In severe cases of the disease, it is worth increasing the dosage to 60-90 mg. For effective treatment of blood pressure, Captopril is taken 3 times a day, 5-13 mg. If no effect is observed, then after a week you can increase the dose to 24 mg.

For heart failure, the drug is also taken at a dosage of 5-13 mg. The dose can only be increased to 24 mg. For this disease, the drug must be taken together with other drugs. After a heart attack, the drug can be taken three days later. Initially, the dose should not be more than 6 mg, but it should be increased after a couple of days. The dosage of Captopril for diabetic nephropathy is 24 mg per day or 60 mg a couple of times a day.

For children under 18 years of age, the drug can only be used in rare and extreme cases. The dose of the drug is calculated depending on body weight. Typically 1.5-3 mg per kg of body weight during the day. While taking the drug, it is necessary to monitor the functioning of the kidneys so that there is no serious complications. When high concentration If there is protein in the urine, it is advisable to stop taking the medication.

If a person has diseases such as vasculitis, connective tissue diseases, renal artery stenosis, the drug should be taken with extreme caution.

Contraindications

Low blood pressure;
Severe renal dysfunction;
Kidney failure and other kidney-related diseases;
Increased potassium levels in the blood.

Also, the medicine is strictly prohibited during pregnancy and cases when a girl is breastfeeding. Prohibited for children under 18 years of age. The drug is contraindicated in case of allergic reactions to substances included in the drug, as well as in cases of hereditary edema.

All these contraindications are reasons to prohibit taking this medicine. However, with the slightest restrictions, you can take the drug, but with extreme caution and consultation with your doctor. These indicators include low levels of leukocytes, platelets in the blood, cerebral ischemia, age over 70 years, renal dysfunction, lupus erythematosus, cardiomyopathy and others.

Overdose

In case of an overdose of the drug, the following symptoms are observed:

Hypotension
A sharp decrease in pressure;
State of shock;
Being in a stupor;
Heart rate decreases (less than 60 beats per minute);
Poor blood circulation in the brain;
Kidney failure;
Angioedema.

In order to eliminate the symptoms of an overdose, it is necessary to prohibit taking the drug, and also to rinse the stomach. In order to replenish blood volume, it is necessary to administer saline. intravenous solution. Also, to eliminate symptoms, they carry out symptomatic therapy. This therapy helps support the functioning important organs for a person. Adrenaline is used for this. If you need to take the drug with other drugs, you should pay attention to drugs that increase potassium in the blood.

You should be careful with painkillers and alcohol, as Captopril significantly enhances their effect. Many drugs significantly enhance the effect of Captopril. These include diuretics and vasodilators. Because of them, blood pressure may decrease.

When taking Captopril with immune drugs there is an increase in the risk of a decrease in the level of leukocytes, as well as the occurrence of other diseases.

Side effects

The drug can cause various side effects, if any of which occur it is necessary to stop taking the drug. First of all, side effects affect the nervous system. A person experiences high fatigue, dizziness, headaches, fainting, frequent drowsiness, depression, possible seizures, and impaired functioning of the senses.

Side effects associated with cardiovascular system and blood circulation are manifested in hypotension of various complexities, the formation of angina pectoris and arrhythmia, cerebral circulatory disorders, chest pain, the occurrence of a heart attack, a decrease in platelet content and other diseases.

The respiratory system when taking the drug gives the following side effects: shortness of breath, pneumonia, bronchitis, as well as rhinitis and cough without sputum.

The drug may cause side effects associated with gastrointestinal tract. Such as the appearance of anorexia, ulcers, taste disturbances, inflammation of the tongue, vomiting, nausea, stomatitis, bloating, sensations of heaviness, pancreatitis and others.

The reproductive and urinary systems also have side effects after using the drug. They are impaired kidney function, an increase or decrease in the volume of urine below the accepted norm, the appearance of protein in the urine, and impotence.

Side effects concern the skin and allergic reactions. They manifest themselves in the appearance of redness or rashes on the body and facial skin, erythroderma and other diseases, urticaria, anaphylactic shock and the appearance of Quincke's edema.

The drug may also cause the following side effects: increased body temperature, chills, joint and muscle pain, blood poisoning, increased potassium levels. decreased amount of sodium and glucose in the blood, decreased hemoglobin, acidosis and others.

Pharmacological action

Angiotensin-II contained in the drug is a hormone that has the property of constricting blood vessels. This hormone helps increase sodium retention in the human body. Captopril is a drug that belongs to the group of ACE inhibitors. Consequently, it can stop enzyme activity and reduce the concentration of the hormone in the blood. Thanks to this, it is possible to reduce vascular resistance and increase cardiac endurance. The drug helps increase blood flow in the vessels that nourish the heart and kidneys.

How the drug can lower blood pressure:

Reduces the activity of angiotensin-converting enzyme;
Stimulates the synthesis of bradykinin - a natural vasodilator (relaxes blood vessels);
Promotes increased synthesis of nitric oxide in tissues;
Minimizes the release of adrenaline and norepinephrine in the blood.
Stops aldosterone synthesis;
Strengthens the elasticity of the arteriolar wall.
Stabilizes blood circulation in the brain in patients hypertension with symptoms of cerebrovascular insufficiency.

How does the drug protect the heart:

Affects the reduction of the mass of hypertrophied left ventricular myocardium, this is most often expressed when combined with calcium channel blockers;
Reduces preload and afterload of the myocardium;
Reduces the frequency of ventricular arrhythmias;
Does better condition coronary circulation;

Captopril is a drug used as an inhibitor drug aimed at lowering blood pressure. The medicine is used in the treatment of arterial hypertension and heart failure.

Currently, the drug is produced in several varieties; they are practically no different from each other, but only indicate the production of the drug at a particular plant. The form of the medicinal product is the same for all types of release.

In this article we will look at why doctors prescribe Captopril, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS People who have already used Captopril can be read in the comments.

Composition and release form

The active ingredient is Captopril. Additional substances: lactose, anhydrous colloidal silicon dioxide, corn starch, hydrogenated castor oil.

Clinical and pharmacological group: ACE inhibitor.

Indications for use of Captopril, at what pressure

Captopril is used to treat following states and diseases:

Arterial hypertension (including renovascular);
Chronic heart failure (as part of combination therapy);
Left ventricular dysfunction after myocardial infarction, provided the patient is in a clinically stable condition;
Diabetic nephropathy caused by type I diabetes mellitus (with albuminuria more than 30 mg per day).

At what pressure is it taken? Captopril is an ACE inhibitor. It has a hypotensive (reduces pressure), vasodilator, cardioprotective, natriuretic effect. Prevents the transition of angiotensin I to angiotensin II and prevents the inactivation of endogenous vasodilators.

Pharmacological action

The effect of Captopril is to suppress the activity of the enzyme that ensures the conversion of angiotensin I to angiotensin II, therefore the drug is classified as an ACE inhibitor (angiotensin-converting enzyme).

Due to the action of the drug, the body does not produce angiotensin II, a substance that has a powerful vasoconstrictor effect and, accordingly, increases blood pressure. When angiotensin II is not produced, blood vessels remain dilated and, accordingly, blood pressure is normal and not elevated.

Thanks to the effect of Captopril, when taken regularly, blood pressure decreases and is kept within acceptable and acceptable limits. The maximum decrease in pressure occurs 1 - 1.5 hours after taking Captopril. But to achieve a lasting reduction in blood pressure, the drug must be taken for at least several weeks (4 – 6).

Instructions for use

According to the instructions for use, Captopril is intended for oral administration. The medicine quickly reduces blood pressure. Only your doctor can prescribe Captopril tablets.

For the treatment of chronic heart failure, captopril is prescribed in cases where the use of diuretics does not provide an adequate effect. The initial dose is 6.25 mg 2-3 times a day, which is then gradually (with an interval of at least 2 weeks) increased. The average maintenance dose is 25 mg 2-3 times/day. In the future, if necessary, the dose is gradually increased (with an interval of at least 2 weeks). The maximum dose is 150 mg/day.
For arterial hypertension, the drug is prescribed at an initial dose of 25 mg 2 times a day. If necessary, the dose is gradually increased (with an interval of 2-4 weeks) until the optimal effect is achieved. For mild or moderate arterial hypertension, the usual maintenance dose is 25 mg 2 times / day; maximum dose – 50 mg 2 times/day. For severe arterial hypertension, the maximum dose is 50 mg 3 times a day. The maximum daily dose is 150 mg.

In old age, the dose of Captopril is selected individually; it is recommended to start therapy with a dose of 6.25 mg 2 times a day and, if possible, maintain it at this level.

Contraindications

Captopril is not intended for use by children under 18 years of age, as well as by women during pregnancy and lactation.
Captopril is also contraindicated in the presence of:

Liver dysfunction;
Arterial hypotension;
Angioneurotic and cardiogenic shock;
Mitral stenosis, aortic stenosis;
Hypersensitivity to the components of the drug.

Captopril should be taken with caution in patients with severe autoimmune diseases, circulatory depression bone marrow, cerebral ischemia, diabetes mellitus, coronary disease heart, as well as people on a sodium-restricted diet and elderly patients.

Side effects

According to the instructions, after using the drug Captopril, patients may experience the following adverse reactions:

facial redness, pallor,
insomnia,
hair loss,
paresthesia;
hyperkalemia,
arterial hypotension (dizziness, vertigo, headache, weakness and fatigue), tachycardia, palpitations, angina pectoris,
skin rash (which may be accompanied by itching or fever, eosinophilia and muscle and joint pain),
renal dysfunction, proteinuria, decreased or increased diuresis, renal failure,
loss of appetite, gastrointestinal disorders(nausea, vomiting, abdominal discomfort, diarrhea, constipation, dry mouth),
loss or change in the sense of taste and a dry cough, which usually disappears a few weeks after stopping treatment with Captopril.
very rarely - neutropenia, agranulocytosis and angioedema.

When treated with Captopril, minor liver dysfunction may occur, and very rarely, jaundice. These disturbances usually disappear after cessation of therapy. Lupus-like syndromes (fever, myalgia and arthralgia, serositis, vasculitis, leukocytosis and eosinophilia) have been reported.

Since Captopril can cause dizziness, during its use it is recommended to avoid potentially dangerous activities that require high reaction speed and concentration.