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Adsorbed diphtheria-tetanus toxoid (ADT toxoid). Diphtheria-tetanus toxoid purified adsorbed liquid (ADS-anatoxin)

Some, even enough educated people They believe that vaccinations are necessary for children and give them at a tender age. However, the information is fundamentally incorrect and there are situations where vaccination is mandatory in adult patients. One of these injections is ADS-M, which prevents the development of diphtheria and tetanus in people at risk.

What is a vaccine

The letters ADS-M are an abbreviation that has the following meaning: “Diphtheria-Tetanus Anatoxin.” The prefix "M" means low concentration active substances. As a result, the patient receives a full-fledged vaccine, but with a reduced number of active antigens.

ADS-M is an injection that protects a person from such dangerous diseases as tetanus and diphtheria. Moreover, adults need vaccination just as much as small children, in some situations. The injection consists of diphtheria and tetanus toxoids. The substances are weakened pathogens of dangerous diseases. At the same time, they can affect the human body just enough so that the immune system begins to actively produce antibodies against “aliens,” but without harming health.

How does the injection affect the body?

Most patients, when they are offered an injection, do not understand what they are getting the ADS-M vaccine for. During the injection, live but weakened toxins are introduced into the body of an adult. They retain their special immunogenic properties, but negative influence unable to provide. As a result, the body detects their presence and begins to actively produce antibodies. Subsequently, if a real infection occurs, it is these substances that will fight the causative agent of tetanus or diphtheria.

Experts will explain that vaccination leads to an erased form of the present disease. But the difference is that there is no threat to health and life, and the person gains immunity for many years.

Who is the injection indicated for?

ADS-M vaccination is indicated for adults. The doctor can tell you in detail why it is done. An injection is required to protect the patient from dangerous manifestations tetanus and diphtheria and is diagnosed every ten years of a person’s life. If the recommended regimen is violated and more than twenty years have passed since the last vaccination, then for complete protection the injection should be given twice. In medical practice it looks like this:

  • the patient is injected with the vaccine and his condition is monitored;
  • if there are no complications, a repeat dose is administered after forty days.

There are situations when the patient has never been vaccinated at all. In this case the following diagram is shown:

  • after the examination, they give the first injection and observe the reaction;
  • if there are no symptoms of intolerance, a second vaccine is given after forty days;
  • To consolidate the result, it is important to make a third injection after a year.

Special cases

The ADS-M vaccine can also be given in in case of emergency By medical indications. If a person is diagnosed with injuries and wounds that have received soil and the vaccination was done more than five years ago, then an injection will be a mandatory procedure.

Elderly people especially need revaccination (repeated injections). They often have an increased susceptibility to infections due to reduced immunity. Therefore, doctors advise this category of patients not to neglect vaccination and not to refer to the presence of chronic diseases. Moreover, similar pathologies are a direct indication for mandatory vaccination.


ADS-M. What is the vaccine for and where is it given?

Tetanus and diphtheria toxoid is produced in the form of a white suspension, which during storage separates into sediment flakes and a white liquid. Therefore, before opening the ampoule, it is recommended to shake it vigorously until smooth.

The ADS-M vaccine has quite mixed reviews. Why and where the injection is given causes multiple disputes between patients. You can often find responses from people who claim that they were given an injection in the buttock. Others claim that vaccination took place under the shoulder blade.

Doctors clarify this situation and they claim that the ADS-M toxoid can be placed both in the scapular part of the back and in the buttocks area. Moreover, there is also a third option. The injection is allowed to be given in middle third outer thigh. A single dosage of the medicine is 0.5 ml.

Vaccination may cause an allergic reaction. Therefore, the patient is not recommended to leave the treatment room where he is being monitored for half an hour. To be able to provide first aid, anti-shock therapy medications must be available in the office.


Vaccination procedure

ADS-M vaccination requires compliance with certain rules. Why and where the injection is given is discussed above; the procedure should only be performed by a specially trained medical worker in a treatment room. In this case, the basic conditions must be adhered to.

The injection is performed only with a disposable, sterile syringe. At the same time as vaccination against tetanus and diphtheria, a person can be vaccinated against other diseases. However, the use of BCG is prohibited. It is also unacceptable to mix all substances in one syringe. Each injection is given separately and in different parts of the body.

Before starting the procedure, the nurse must carefully examine the ampoule to ensure its suitability. If there is no information about the vaccine on the bottle, or it is damaged and the contents have a suspicious consistency, then it is prohibited to administer it. It is important to comply with storage conditions and pay attention to expiration dates.

The procedure is carried out under conditions that fully comply with antiseptic requirements. The ampoule is opened, drawn into a syringe and used entirely. If for some reason it was not possible to use all the contents, the bottle is discarded. It can no longer be stored.

It is necessary to enter patient data into a special registration journal. The following information is also entered there:

  • vaccine serial number;
  • date of its production;
  • date of vaccination;
  • reaction to the injection.

The patient's condition should be closely monitored. If after thirty minutes the state of health is beyond doubt, then you can leave the medical facility.

Contraindications for injection

To serious medical drugs refers to ADS-M. The instructions clearly state situations when it is prohibited to give an injection. Contraindications for unvaccinated adult patients include:

  • severe diseases associated with immunodeficiency;
  • allergic reaction to vaccine components;
  • negative reaction to the previous injection.

In addition, there are restrictions on injection. It is necessary to postpone the procedure in women during pregnancy and lactation. If the patient has had acute infectious infections, then a medical exemption is given for two weeks.

Side effects

The ADS-M vaccine has quite mixed reviews. Not all patients like where the injection is given. In addition, the location may vary. If they were injected under the shoulder blade, patients complain of the inability to raise their arm, if in the buttock, then sometimes it hurts to sit down. The responses are all different. Some feel nothing, others develop a fever. Frequent complaints is:

  • redness at the injection site;
  • runny nose and general malaise;
  • muscle pain at the injection site.

However, doctors claim that such a reaction to the vaccine is normal occurrence. Similar conditions indicate the body’s struggle against “aliens” and the development of stable immunity. Usually after some time negative symptoms pass on their own. After all this vaccination considered one of the less reactogenic.


Side effects may occur easy character, but sometimes manifest themselves in a more severe form. It is especially important to monitor the patient's condition in the first 48 hours. At this time, the temperature often rises, redness and swelling appear at the injection site. If a lump appears, there is no need to panic. It resolves on its own within a couple of weeks. However, doctors warn that in order to avoid suppuration, heating this place is prohibited.

Experts emphasize that even a severe reaction to a vaccine is not considered a pathology. There will be no consequences for health, even if a person feels very uncomfortable in the first days. However, it is worth considering the possibility of a persistent allergic reaction, which may serve as a contraindication to revaccination.


Vaccine analogues

The ADS-M vaccine has several analogues. What it is given for is a priority in choosing the appropriate injection. Analogues have similar composition, mechanism of action. Differences in the country of origin.

  • "D.T. Wax." French pharmaceutical company.
  • "Imovax D.T. Adultery." French production.

Of course, the choice will depend on the availability or absence of a particular drug in a medical facility. You can purchase the vaccine you want yourself, but as reviews show, Russian product no worse than imported analogues.


Dosage form:  suspension for intramuscular injection Compound:

ADS toxoid consists of a mixture of purified diphtheria and tetanus toxoids adsorbed on aluminum hydroxide.

1 dose (0.5 ml) contains: 30 flocculating units(Lf) diphtheria toxoid and 10 binding units (EC) of tetanus toxoid; Excipients: no more than 0.55 mg of aluminum hydroxide (in terms of aluminum), from 42.5 to 57.5 mcg of thiomersal and no more than 50 mcg of formaldehyde.

 Description:

The suspension is yellowish-white in color, separating upon settling into a clear supernatant liquid and a yellowish-white loose sediment, completely breaking up when shaking.

 Pharmacotherapeutic group: MIBP-anatoxin ATX:  

J.06.A.A Immune serums

J.06.A.A.02 Tetanus antitoxin

J.06.A.A.01 Diphtheria antitoxin

Pharmacodynamics:Administration of the drug in accordance with the approved regimen causes the formation of specific antitoxic immunity against diphtheria and tetanus. Indications: Prevention of diphtheria and tetanus in children. Contraindications:

WITHsevere reaction or post-vaccination complication to a previous vaccine administration

- acute infectious and non-communicable diseases- vaccinations are carried out no earlier than 2-4 weeks after recovery. For mild forms of disease (rhinitis, mild hyperemia of the pharynx, etc.), vaccination is allowed after disappearance clinical symptoms;

- chronic diseases - vaccinations are carried out upon achieving complete or partial remission;

- neurological changes - vaccinated after the progression of the process has been ruled out;

- allergic diseases - vaccinations are carried out 2-4 weeks after the end of the exacerbation, while stable manifestations of the disease (localized skin phenomena, hidden bronchospasm, etc.) are not contraindications to vaccination, which can be carried out against the background of appropriate therapy.

Pregnancy and lactation: Directions for use and dosage:

ADS toxoid is administered intramuscularly in the anterior outer part of the thigh in a dose of 0.5 ml. Before vaccination, the ampoule must be thoroughly shaken until a homogeneous suspension is obtained.

ADS toxoid is used:

1. Children who have had whooping cough (from 3 one month old before reaching 6 years of age).

2. Children who have contraindications to the administration of DTP vaccine.

3. Children aged 4-5 years inclusive, who have not previously been vaccinated against diphtheria and tetanus.

The vaccination course consists of two vaccinations with an interval of 30 days. Reducing the interval is not allowed. If it is necessary to increase the interval, the next vaccination should be carried out as soon as possible, determined by the child’s health condition. Revaccination with ADS toxoid is carried out once every 6-12 months.after the completed course of vaccination. The first revaccination of children over 6 years of age, as well as subsequent age-related revaccinations, are carried out with ADS-M toxoid.

ADS toxoid can be administered a month later or simultaneously with polio vaccine and other drugs national calendar preventive vaccinations.

Note.If a child who has had whooping cough has previously received three or two vaccinations with DPT vaccine, the course of vaccination against diphtheria and tetanus is considered complete. In the first case, revaccination with ADS toxoid is carried out after 12-18 months, and in the second - 9-12 months after the last administration of the drug. If a child has received one vaccination with the DTP vaccine, he is subject to a second vaccination with the DTP toxoid vaccine, followed by revaccination after 9-12 months. Subsequent age-related revaccinations are carried out with ADS-M toxoid.

The administration of the drug is recorded in the established accounting forms, indicating the batch number, expiration date, manufacturer, date of administration, and the nature of the reaction to the administration of the drug.

 Side effects:

ADS-toxoid is a weakly reactogenic drug. Some vaccinated people may develop short-term general (fever, malaise) and local (pain, hyperemia, swelling) reactions in the first two days. Considering the possibility of development allergic reactions immediate type(Quincke's edema, urticaria, polymorphic rash) in particularly sensitive persons, vaccinated persons must be provided with medical supervision for 30 minutes. Vaccination sites must be provided with anti-shock therapy.

Note. If a child develops a strong general reaction (temperature rise to 40 °C or higher) or a post-vaccination complication, further vaccinations with ADS toxoid are stopped. If a child has received two vaccinations with ADS-toxoid, the vaccination course is considered complete; if the child has received one vaccination with ADS-toxoid, then vaccination can be continued with ADS-M-toxoid, which is administered once no earlier than 3 months later. In both cases, the first revaccination is carried out with ADS-M toxoid 9-12 months after the last vaccination.

Subsequent revaccinations are carried out at 6-7 and 14 years of age with ADS-M toxoid.

When the temperature rises above 38.5 °C in more than 1% of vaccinated people or when severe local reactions occur (swelling of soft tissues with a diameter of more than 5 cm, infiltrates with a diameter of more than 2 cm) in more than 4% of vaccinated people, as well as with the development of severe post-vaccination complications of vaccination the drug in this series is discontinued.

 Overdose: Not installed. Interaction: Not established. Special instructions:

Immunodeficiencies, HIV infection, and supporting course therapy, including steroid hormones and psychopharmaceuticals are not contraindications to vaccination.

In order to identify contraindications, the doctor (paramedic at the FAP) on the day of vaccination conducts a survey and examination of the vaccinated with mandatory thermometry. At vaccinations for adults preliminary selection of persons to be vaccinated is allowed, with their questioning medical worker vaccinating on the day of vaccination. Persons temporarily exempt from vaccination must be monitored and registered and vaccinated in a timely manner.

Vaccinations according to epidemiological indications: non-immune persons with the diseases specified in the section “Contraindications for use”, who are in direct contact with patients with diphtheria (family, class, dorm room, etc.), can be vaccinated according to the conclusion of a specialist until recovery (remission) ) against the background of appropriate therapy.

Precautions for use.

The drug is not suitable for use in ampoules with damaged integrity, lack of labeling, if physical properties(change in color, presence of unbreakable flakes), when expired expiration date, improper storage.

The opening of ampoules and the vaccination procedure are carried out in strict compliance with the rules of asepsis and antiseptics. The drug cannot be stored in an opened ampoule.

 Impact on the ability to drive vehicles. Wed and fur.:

Not applicable because this drug intended for use in children.

 Release form/dosage:Suspension for intramuscular administration. Package:

In ampoules of 0.5 ml (one vaccination dose) or 1 ml (two vaccination doses). 10 ampoules per box with instructions for use and a scarifier, or 5 ampoules in a blister pack made of polyvinyl chloride or polystyrene film, 2 ampoules per pack with instructions for use and a scarifier.

FSUE NPO Microgen, Ministry of Health of the Russian Federation, JSC Biomed, Russia

  • Release form: 1 ampoule / 2 doses No. 10.
  • Vaccination schedule: prevention of diphtheria and tetanus according to the National Vaccination Calendar in children from 6 years of age, adolescents and adults.

Instructions for use

Registration Certificate Holder:

NPO MICROGEN, Federal State Unitary Enterprise (Russia)

ATX code: J07AM51 (Tetanus toxoid, combinations with diphtheria toxoid)

Dosage form

reg. No.: LS-000283 from 04/27/10 - Indefinitely

Release form, composition and packaging

0.5 ml (1 dose) - ampoules (10) - cardboard packs.

Clinical and pharmacological group: Immunological drug. Anatoxin

Pharmacotherapeutic group: MIBP-anatoxin

Given scientific information is general and cannot be used to make a decision about the possibility of using a specific drug.

pharmachologic effect

Forms specific immunity against diphtheria and tetanus.

Indications

  • prevention of diphtheria and tetanus in children from 6 years of age, adolescents and adults.
    ICD-10 codes

Dosage regimen

IM into the upper outer quadrant of the buttock or the anterior outer part of the thigh or deep subcutaneously (adolescents and adults) into subscapular region in a single dose of 0.5 ml.

Before administration, the drug must be shaken thoroughly until a homogeneous suspension is obtained.

For planned age-related revaccinations at 7 and 14 years of age, then every subsequent 10 years without age limitation - once.

For vaccination children 6 years and older, previously unvaccinated against diphtheria and tetanus - the vaccination course consists of two vaccinations with an interval of 30-45 days. Reducing the interval is not allowed. If it is necessary to increase the interval, the next vaccination should be carried out as soon as possible. The first revaccination is carried out 6-9 months after the completed vaccination once, the second revaccination is carried out at an interval of 5 years. Subsequent revaccinations are carried out every 10 years without age restrictions.

As a replacement for diphtheria-tetanus-pertussis vaccine (DPT vaccine) or diphtheria-tetanus toxoid with standard concentration of antigens (ADT toxoid) in children with strong general reactions(hyperthermia up to 40°C and above) or post-vaccination complications to these drugs. If the reaction develops to the first DPT vaccination(ADS), then ADS-M toxoid is administered once no earlier than 3 months later; if a reaction develops to the second vaccination, then the course of vaccination against diphtheria and tetanus is considered completed. In both cases, the first revaccination with ADS-M toxoid is carried out after 9-12 months. If a reaction has developed to the third DPT vaccination (ADS), the first revaccination with ADS-M toxoid is carried out after 12-18 months.

To carry out a course of vaccination adults, who have not previously been reliably vaccinated against diphtheria and tetanus are full course immunization (two vaccinations with ADS-M toxoid with an interval of 30 days and revaccination after 6-9 months).

IN foci of diphtheria preventive vaccinations carried out in accordance with the instructions and methodological documents of the Russian Ministry of Health.

Side effect

Rarely(in the first two days): hyperthermia, malaise, local reactions(pain, hyperemia, swelling); in isolated cases- angioedema, urticaria, polymorphic rash, minor exacerbation of allergic diseases.

Contraindications for use

  • hypersensitivity;
  • pregnancy.

Use during pregnancy and breastfeeding

Contraindicated for use during pregnancy.

Use in children

Application is possible according to the dosage regimen.
Children with neurological disorders are vaccinated after progression of the process has been ruled out.

special instructions

Persons who have suffered acute diseases are vaccinated 2-4 weeks after recovery. In mild forms of the disease, vaccinations are allowed after the clinical symptoms disappear.

Patients with chronic diseases are vaccinated upon achieving complete or partial remission. Children with neurological disorders are vaccinated after progression of the process has been ruled out. Sick allergic diseases vaccinations are carried out 2-4 weeks after the end of the exacerbation, while stable manifestations of the disease (localized skin phenomena, hidden bronchospasm) are not contraindications to vaccination, which can be carried out against the background of appropriate therapy.

Immunodeficiencies, HIV infection, as well as maintenance course therapy (including GCS) are not contraindications to vaccination.

In order to identify contraindications, on the day of vaccination, the doctor conducts a survey of parents and examines the vaccinated with mandatory thermometry. When vaccinating adults, preliminary selection of persons to be vaccinated is allowed, with their interview by the medical worker conducting the vaccination on the day of vaccination. Persons temporarily exempt from vaccination must be monitored and registered and vaccinated in a timely manner.

If epidemiologically necessary, ADS-M toxoid can be administered against the background acute illness. In case of a strong reaction, do not previous dose of this drug, a repeated dose is administered against the background of the use of corticosteroids (oral prednisolone - 1-1.5 mg/kg/day the day before and immediately after vaccination).

Persons vaccinated with tetanus toxoid are vaccinated with diphtheria toxoid between revaccinations.

ADS-M toxoid can be administered a month later or simultaneously with the polio vaccine and other vaccines in the national vaccination schedule.

Considering the possibility of developing immediate allergic reactions in particularly sensitive individuals, vaccinated individuals must be provided with medical supervision for 30 minutes. Vaccination sites must be provided with anti-shock therapy.

Persons who have given severe forms of allergic reactions to the administration of ADS-M toxoid, routine vaccinations the drug is stopped.

Not suitable for use in ampoules with damaged integrity, lack of labeling, changes in physical properties (change in color, presence of unbreakable flakes), or improper storage.

The opening of ampoules and the vaccination procedure are carried out in strict compliance with the rules of asepsis and antiseptics. The drug cannot be stored in an opened ampoule.

The administration of the drug is registered in the established accounting forms, indicating the batch number, expiration date, manufacturer, and date of administration.

Rotavirus infection: what is important to know?

There are several types of the virus, but serotypes A, B, C are pathogenic for humans, and the most common type is A. This virus affects not only humans, but also different types mammals and birds. Group A rotavirus is considered one of the most common reasons emergence infectious diarrhea in children.

Poliomyelitis is acute infection person, which is accompanied by defeat nervous system, development of paresis and paralysis. Polio mainly affects children under 5 years of age. 1 in 200 infections results in permanent paralysis. Among those paralyzed, 5% to 10% die when their breathing muscles become immobile.

Many parents panic, confusing rotavirus, dysentery and poisoning. Doctors warn that one of the main differences is stool character.

IN last years the world is developing ambivalence to vaccinations. Despite the fact that universal vaccination against some diseases has led to their almost complete disappearance, the ranks of opponents mandatory vaccinations grow. This is facilitated by wide use misconceptions regarding vaccination.

In organism healthy person There are a trillion beneficial (85%) and one hundred and fifty billion pathogenic (15%) microorganisms. Throughout their lives they compete with each other. If the balance shifts towards pathogenic bacteria, the microflora is destroyed, dysbacteriosis occurs, a person’s well-being worsens, and the question arises “how to restore health.”

Sorbed on. Preservative – merthiolate.

Release form

Colorless liquid with a slightly yellowish or white precipitate.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

After administration, Diphtheria-Tetanus Anatoxin (ADT-anatoxin) helps to develop persistent immunity To tetanus And diphtheria , preventing the occurrence of these diseases. It is a solution with weakened bacterial toxins. These substances, entering the body, trigger a series of biochemical reactions that activate the formation of the pathogen.

However, the drug, as a rule, does not provoke the development of the disease itself. Its use, on the contrary, helps suppress infections , so that foreign agents entering the body do not cause disease.

IN medical institutions In addition, specialists use -anatoxin. It also promotes the production immunity against pathogens diphtheria And tetanus , but its content is reduced.

Indications for use

The drug is used for the following purposes:

  • Planned revaccination patients from 7 years old.
  • Injections patients over 7 years of age who have already had vaccinations from diphtheria And tetanus .
  • Vaccination patients for whom there is no reliable data on vaccinations from tetanus And diphtheria .

Contraindications

It is contraindicated to do injections with exacerbation of chronic diseases and. When acute infectious diseases vaccinations are given 2-4 weeks after recovery.

Side effects

IN in rare cases after injections observed painful sensations at the injection site, swelling , increased body temperature, exacerbation, general weakness, hyperemia , .

Due to the risk of developing severe allergic manifestations After vaccination, patients should be monitored for 30 minutes. In venues injections must be provided antishock therapy .

If allergic reactions occur in severe forms course of injections is interrupted.

Instructions for use (Method and dosage)

ADS toxoid is administered in a single dose of 0.5 ml intramuscularly into the anterior outer part of the thigh or under the shoulder blade, deep subcutaneously.

Before the injection, the ampoule with the drug should be shaken well.

Conduct planned age-related revaccination at 7 and 14 years old, and then vaccinations done every 10 years.

Course of injections includes two vaccinations, the interval between which is 30-45 days. This interval cannot be shortened. If it needs to be increased, the next vaccination is given as soon as possible.

After the completed one-time vaccinations first revaccination carried out after 6-9 months. Second revaccination must be carried out after 5 years.

If a negative reaction to ADS toxoid develops, once inject ADS-M toxoid after at least three months. In cases where unwanted side effects appeared on the second vaccination , course of injections don't continue.

For vaccinations adult patients who have not previously been reliably vaccinated against diphtheria And tetanus use ADS-M toxoid. Make two vaccinations with an interval of 30 days. Revaccination carried out after 6-9 months.

Overdose

Data on overdose are not provided.

Interaction

ADS-M-anatoxin injected in a month or together with polio vaccine .

Terms of sale

This drug is not sold in pharmacies. It is supplied only to medical institutions.

Storage conditions

It is necessary to store ampoules in a dry and dark place. The optimal temperature is about 6°C. The drug should not be frozen.

Best before date

ADS-anatoxin should not be stored in closed ampoules for longer than 36 months.

Reviews: 20

In the understanding of many people, vaccinations should be carried out once or at most three times. This is enough to develop immunity. But there are vaccines that are given constantly, until old age at certain intervals. Such a vaccine is ADS-M - a vaccine against diphtheria and tetanus.

What kind of injection is this and why do it throughout your life? What is the ADS-M vaccine for and how often is it given?

Why get vaccinated against diphtheria and tetanus?

Several decades ago, the words diphtheria and tetanus terrified not only people whose family had such illnesses. Doctors were afraid to diagnose these particular diseases. They are from the category of those for which it is much easier to prevent than to cure. If a person is lucky enough to survive one of these diseases, then complications often bother him for the rest of his life. Nowadays, cases of morbidity are becoming less common thanks to vaccination against diphtheria and tetanus.

Diphtheria and tetanus belong to the group of acute bacterial infectious diseases. The source of infection is a sick person, and in the case of tetanus, animals can also be carriers of the infection.

Diphtheria affects the upper Airways. Clinical manifestations with the following:

  • slight increase temperature, weakness, increase cervical lymph nodes;
  • sore throat, swelling of the neck tissue, difficulty swallowing food, including liquid food;
  • inflammation of the pharyngeal mucosa, enlarged tonsils;
  • distinctive prognostic signs The disease is the appearance of plaque on the tonsils, which can spread to neighboring tissues.

Complications of diphtheria: heart damage, paralysis of the neck muscles and soft tissues, disruption of the nervous system. In heavy and advanced cases- death. At what age do you get vaccinated against diphtheria? The introduction of the first complex vaccine begins three months after the birth of the child.

The symptoms of tetanus differ because the nervous tissue is more affected. The disease is characterized by:

  • elevated temperature, weakness;
  • tension and spastic contractions of the facial muscles;
  • muscle tension in the neck, torso and limbs;
  • difficulty breathing;
  • death may occur due to a sharp spasm of the respiratory muscles.

Both diseases affect nervous tissue and cannot be treated with conventional or even super-strong treatments. antibacterial drugs. Diseases are much easier to tolerate or cases occur less frequently if vaccination is completed in a timely manner. For this purpose, children and adults are vaccinated with ADS-M. According to the calendar, the first injections (DTP - complex vaccine with whooping cough) are carried out at 3, 4.5 and 6 months. The first revaccination should be at 18 months. The second revaccination with ADS-M should be at 7 years of age, then at 14. After which it is repeated every 10 years throughout life. Age is not a limitation for the prevention of such serious illnesses- Diphtheria and tetanus can affect a person at any time in his life.

What kind of vaccine is ADS-M?

Various options There are so many prophylactics for diphtheria and tetanus that you can’t help but wonder - is each of them necessary? What is the composition of the ADS-M vaccine and what does each symbol mean? One dose of the ADS-M vaccine - 0.5 ml of substance contains:

  • 5 units of diphtheria toxoid;
  • 5 tetanus toxoid binding units;
  • excipients: thiomersal, formaldehyde, aluminum hydroxide.

The usual packaging of ADS-M contains ampoules of 1 ml, that is, each contains 10 units of each toxoid.

What is different about this particular vaccine? ADS - these symbols indicate purified adsorbed liquid diphtheria-tetanus toxoid. The capital “M” refers to reduced levels of antigens.

The ADS vaccine, for example, contains 60 units of diphtheria and 20 units of tetanus toxoids. That is, the number of active units against each disease is significantly increased. How else is ADS different from ADS-M? These are indications for use. For each of these drugs there are clear criteria for administration.

ADS-M instructions

The ADS-M vaccine is produced in the form of a yellowish-white suspension. Each ampoule contains 1 ml of the substance - this is a double dose of toxoid. According to the instructions for the ADS-M vaccine, it is used:

  • for the prevention of diphtheria and tetanus in children from the age of six;
  • used in adolescents and adults every 10 years;
  • the ADS-M vaccine is administered to adults who have not received a vaccine in the last 20 years;
  • in rare cases, the ADS-M vaccine is given as a replacement for DPT or ADS vaccines in children with strong reactions or post-vaccination complications to these drugs;
  • children of four years of age who have not previously received DPT.

The ADS-M vaccine is a drug that is used to support immunity throughout life.

Where is the ADS-M vaccine given? According to the new instructions, the drug is administered intramuscularly into the anterior outer part of the thigh or deep subcutaneously into the subscapular region (adolescents and adults).

Contraindications for the use of ADS-M

There are both permanent and temporary contraindications for ADS-M vaccination.

Permanent contraindications include:

  • a pronounced reaction to the ADS-M vaccine during its previous administration;
  • complications after the first or subsequent vaccinations.

Temporary contraindications are as follows.

In the event that the vaccination schedule has been disrupted, a half dose of the drug is administered, and then a revaccination is given - RV2 a month later and RV3 at least 30–45 days after the previous one.

Reaction to ADS-M vaccination

After administration of toxoid, some local or general reactions.

All the most serious complications according to the type of damage to the nervous system, inflammation of the meninges and collapse could occur in the case of administration of the whooping cough vaccine - DTP.

ADS-M is well tolerated; complications and reactions to this vaccine occur due to improper behavior of the person himself. They are possible when scratching the injection site, if a person, contrary to the ban, wet it, or visited crowded places within two days after vaccination. In such cases, the reaction may not have occurred to the vaccine itself. The most frequently asked question to doctors is whether it is possible to wash after vaccination against diphtheria and tetanus? In general, it is possible, but not possible, to wet the injection site of the toxoid.

Similar vaccines for diphtheria and tetanus

There are several analogues of the diphtheria and tetanus vaccine:

  • ADS-M anatoxin (Russia);
  • "Imovax D.T. Adult" (France);
  • “D.T. Wax" (France).

Complications for any of these vaccinations are minimal and often depend on the human factor. All of them are well tolerated. The substances include the same toxoids, but the stabilizers may be different.

Let's summarize. When should you get the ADS-M vaccine? To build immunity against diphtheria and tetanus. All adults are vaccinated starting from the age of 14 or 16 (old calendar) and every 10 years in the absence of contraindications. Any unvaccinated person belongs to the risk group - these people not only can get sick themselves, they will infect other people, including children who still have weak immunity. One ADS-M vaccination will not easily get rid of yet another paperwork in the clinic, but it may save loved one from death!

You can rate the article:

    Why does the article omit information about the presence in the ADS-M vaccine of the merthiolate preservative, which is poisonous? chemical compound, especially neurotoxic in combination with the aluminum contained in the vaccine?

    Tatyana Vitalievna, the article talks about merthiolate, only it is designated in it under a different name trade name- Thiomersal. It is used as a preservative and its amount in the vaccine is tiny - 0.05 mcg (microgram), the effect on the body is negligible.

    Hello, help me figure it out, the child was treated with Ads 2 times before the age of one year, now the child is 1 year and 10 months old, the pediatrician said that Ads should be done again. Is this true and how many times should I do it? I thought that it was already done at the age of 7.

    The child was given ADMS at school, notified in September, vaccinated almost two months later in November, the daughter recently suffered from ARVI, had herpes on her lips, and despite all this, she was vaccinated. Now we have conjunctivitis, a sore throat, the temperature reaches 40.5, an increase in the number of herpes, and in childhood we also had complications after DPT vaccinations. What to do, where to go to have your child examined, to get good treatment!

    Good afternoon Very useful article, Thank you. It so happened that we were mistakenly given both Pentaxim and our Russian DTP vaccine on the same day. The child tolerated it normally, tell me how to proceed with the vaccination, and what consequences there may be in the future due to the double dose of DPT and different drugs, thank you in advance.

    What to do? A 56-year-old woman, after a tetanus vaccination, developed angioedema and a temperature of 38 within an hour; on the 11th day she developed tachycardia, fever, weakness and drowsiness. Today, on the 15th day after vaccination, hives all over the body. Should I do the rest of the vaccination or is it dangerous to life and health?

    Svetlana, you should definitely inform your doctor about such a reaction, and he will decide whether or not you can do the “remaining part of the vaccination.” Although it is not clear what this “remaining part” is, since this vaccination in adulthood is done once every 10 years.

    Roman, thank you for your response. Vaccination in three steps: the first stage is a test, the second (in half an hour) is the vaccination itself, and they also told you to come back in a month for the third vaccination.

    “Insignificant” influence? Is it methylmercury, aluminum hydroxide and formaldehyde? What does reference literature tell us about them? A..., are especially toxic, even when inhaled and eaten, cause necrosis skin(death of skin). Lizards, snakes and other visual aids “preserved in alcohol” are stored in formaldehyde. What about direct entry into the bloodstream - and from there directly into the brain - of methylmercury, aluminum hydroxide and formaldehyde? What is going to be there? Where can you read about this? For example, links to studies, experiments on rabbits, vaccinated for 3-5 generations in a row. Do you have them ;)? And autism (brain damage), you say, has nothing to do with vaccinations?
    I personally checked the antibody titer - it turned out to be very high - while “re-vaccination” is not only not required, but CONTRAINDICATED! The analysis is not very expensive. And health is priceless!

    Contraindicated until you or your family are sick with diphtheria and suffer from it. If you are not able to read authoritative foreign sources (oh yes... Further cut out by the site administrator - insult, incitement to hatred and enmity), but also simply calculate the probability of dying from a sore and getting any complications from vaccination (spoiler: the chances are one in several hundred thousand) - that’s where you’re headed.

    Inna, yes, in Russia they “go crazy” - I will/won’t get vaccinated. It is clear that the situation in Ukraine is different and there are simply no vaccines - I would be glad to supply them, but there is nothing or it is very expensive)))

    Please don't argue! There is definitely harm. And many children remain disabled with impaired brain function. It's just hidden! They don't advertise. There is a risk. And before getting vaccinated, you need to take tests, examine the child, and collect a complete medical history. They didn’t just look down your throat and send you for vaccination. And by the way, please note that the vaccinations that are administered to children have not previously been experimented on animals.

    Maya, why can’t we argue? For example, “a lot of children become disabled” - how many exactly? There is evidence that statistics side effects hiding? Where does the data come from that experiments are not being carried out?

    I am interested in the time interval between the first DPT revaccination and the second DPT-M revaccination.

    Maya, people with brain disorders are born, not after vaccination. And the reason is the total alcoholism of our fellow citizens. For some reason this doesn’t stop anyone from using it.

    What total alcoholism, what nonsense! You are busting your ass over vaccinations because you were lucky enough not to face any real problems after it! After the DPT revaccination, my son started having problems. Born healthy, 9 points on the scale, developed wonderfully (we lead correct image life, we don’t smoke or drink with my husband), BUT after it the child lost all acquired skills, he stopped talking!!! We were diagnosed with autism at age 2! And you don’t need to write to me that he was born this way, he was healthy BEFORE the vaccination. Doctors shrug their shoulders and say, well, you are one of the 3% of children who were affected by the vaccine in this way. So those who are tearing their throats out here and expressing bewilderment as to why we are “getting crazy,” I want to say, you live under the slogan “is your child not disabled yet? Then we go to you!"
    As a mother, I wish you with all my heart that you do not fall into these 3%... You can’t even imagine what I had to experience. Ingeborga dapkunaite (?), this is not a childhood vaccine... Children are given DPT. Are you sure you're not making things up?

    I believe that vaccinations should be done, but not all in a row, based on various factors. For example, I don’t see the point in sculpting Ads-m vaccination, especially in adulthood, if for example a person received open wound, somewhere working in the field he should do antitetanus serum, if there are no outbreaks of diphtheria in the region, why should they be given to children over seven years old... I vaccinate my son, because we travel a lot to Asian countries, here you will never know who you came into contact with at the airport and what diseases you can pick up in India , V in this case“It’s better to be safe than sorry.” Regarding complications, there is a lot of talk about autism now, and the statistics are disappointing, and it is not clear whether this condition manifests itself after vaccinations or whether it is still congenital and the vaccination already spurs the disease. Regarding preservatives - they, of course, contain a lot active ingredients and you need to know about this, although they are in microscopic doses, and some of the commentators are already poisoning rabbits with formaldehyde - they also compared, if you live in the city, you are poisoned much more every day, but for some reason you are only worried about the vaccine... Regarding statistics As for side effects, I personally believe that no one keeps statistics, side effects, I won’t even talk about a banal increase in temperature - this is just the norm, considering that it is a disease that is being administered, not vitamins. But there are complications and this depends, first of all, on the quality of the vaccination. My friend’s child couldn’t get up for two days and was screaming, who recorded this for statistics? They just installed a medical outlet and that’s it... And I’m against vaccinations from birth, even in the maternity hospital they diagnose hepatitis - it’s unlikely that in a normal family a child will encounter this disease in infancy, and if he breastfeeding he already has protection. I gave the first vaccination at 8 months, although it could have been a couple of months later, based on the fact that the child begins to walk and come into contact with environment more actively... Those who categorically refuse vaccinations are still advised to do them in cases where there are outbreaks of one of the diseases in the region or if you are planning to travel (before the trip, the vaccination must be done very well in advance) because these are fatal diseases that are difficult to treat...

    In principle, I am in favor of vaccinations, but of course you need to look at your own and your child’s condition. I gave my daughter all the vaccinations, but not our Russian ones, because the first DTP given at the clinic, due to my ignorance, even then caused an unpleasant reaction, as described above - the child was simply replaced, for a week I didn’t know what to do with it and where run, the child did not eat, did not sleep, cried, constantly sat in our arms, so we gave the rest of the vaccinations Pentaxim and there were no more such reactions.