Sinusitis

Liv 52 causes cancer. Interaction with other drugs

This article will tell you about a prominent representative of hepatoprotective type drugs - Liv 52. We will tellabout its benefits and harm to the liver,nuances of use,methods of application.

This hepatoprotector is recognized as one of the best in its class and has helped many people regain health and prevent the occurrence of severe forms of liver and biliary tract diseases.

Description of the drug

Liv 52 is a combination medicine of herbal origin. Is:

hepatoprotective;
choleretic;
antioxidant;
antianorexic agent.

Applicable:

in the early stages of development of hepatitis A and B (B);
with alcoholic and toxic damage to liver cells;
digestive disorders;
deterioration of food digestibility.

Forms of release of the drug

Round tablets of green-gray color with dark inclusions, 100 tablets in a plastic bottle.
Liv 52 capsules, 100 pieces per bottle.

Many people are interested in the question of what Liv 52 tablets are needed for and what they help with, if there are more effective forms - capsules and drops? Tablets are used to take in smaller doses, since the dosage in a capsule is much more difficult to calculate. Photo: tablets

Composition of the medicine

The effectiveness and benefits of Liv 52 are due to a unique combination of beneficial properties of a number of medicinal plants and their derivatives.

Each tablet contains the following active ingredients:

pharmachologic effect

A complex of biologically active substances that are part of the drug:

normalize liver function;
contribute to the active restoration of its cells;
better digestibility of food;
activate digestion.

The medicine also has a preventive mechanism to protect liver cells from the effects of alcohol, drugs and harmful environmental influences.

Pharmacodynamics and pharmacokinetics

Conducting studies on pharmacodynamics and pharmacokinetics is not possible. This is due to the fact that the therapeutic effect of Liv 52 for liver cells is due to a wide range of effects:

various medicinal plants;
biologically active substances.

Indications for use

Liv 52 is indicated for use as a preventive and therapeutic agent for patients with:

acute form of hepatitis A with severe course of the disease;
chronic form of hepatitis C and B;
exhaustion of the body due to poor digestibility of food;
alcoholic fatty liver;
living in areas with unfavorable environmental conditions.

with prolonged treatment with antibiotics;
as a preventive measure against exhaustion of the body during chemotherapy, for example, for cancer or metastases in the liver;
as a hepatoprotector during long-term use of oral contraceptives.

The drug can help with weight gain in case of anorexia.

How to take Liv 52 or instructions for use

For preventive purposes, the drug is used 2 tablets 2 times a day.
When using the medicine in children over eight years of age, it is not recommended to take more than 2 tablets per day in two doses.
When taking the drug for medicinal purposes by adults, prescribe 2 tablets 2-3 times a day.
Taking Liv 52 drops by children is not recommended. Adults are prescribed 80-100 drops 2 times a day.
In all cases, the course lasts from 2 to 3 months with breaks of 3 weeks throughout the year.
It is not recommended to take the drug before meals. Although, according to the instructions, it does not matter how to take Liv 52 - before or after meals.

Overdose

There were no cases of overdose when using the medication. However, there is a possibility of various allergic reactions with prolonged use of Liv 52 in large quantities.

Contraindications

Allergy to the components of the drug.
Pregnancy.
Diseases of the biliary tract.
Acute forms of intestinal diseases.
Stomach diseases.
Individual intolerance to the components of the drug.

Side effects

With moderate use, no side effects were found, however, with prolonged use, allergic reactions and dyspepsia may occur. Photo: drops

Drug interactions

While taking the drug, drinking alcohol is strictly prohibited. Also, when using the medicine Liv 52 and its analogues, it is not recommended to use antibiotics of the tetracycline group, as this will reduce the effectiveness of the medicine. In other cases, the drug does not have a significant effect on other drugs.

When taking Liv 52 on your own, you must read the instructions for use.

Terms and conditions of storage

Store in a dry place, out of reach of children, at a temperature of +10 to +30°C.

Analogues

There are currently no analogues of the product in terms of structural components, however, there are many analogues in the pharmacological group. For example, Holenzym. Most of them are also made from natural raw materials and have a lot of positive reviews. In this case, only price plays a role. At the same time, Liv 52 is inferior in this indicator to many of its analogues. Here is just a small list of the most famous of them:

Silymarin;
Phosphonciale;
Holenzim.

Opinion and reviews about the drug

Until now, the effectiveness of the product has not been proven directly through laboratory studies. There are various rumors about the advisability of its use. A number of studies have shown that it should be used only for preventive purposes, and for therapeutic purposes - for non-acute forms of diseases.

In this article you can read the instructions for use of the drug Liv 52. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Liv 52 in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Liv 52 in the presence of existing structural analogues. Use for the treatment of hepatitis, cirrhosis and other liver diseases in adults, children, as well as during pregnancy and lactation. Composition of the drug.

Liv 52- combined herbal preparation. It has hepatoprotective, antitoxic, anti-inflammatory, choleretic, antioxidant, antianorexic effects. Helps improve the process of digestion and absorption of food.

The hepatoprotective effect of Liv 52 is due to the antioxidant and membrane-stabilizing properties of its constituent components. The drug increases the level of endogenous tocopherols in hepatocytes and the level of cytochrome P450. Liv 52 stimulates the biosynthesis of proteins and phospholipids. Promotes the restoration of hepatocytes, reduces degenerative, fatty and fibrotic changes, enhances intracellular metabolism.

The drug regulates the level of plasma proteins in the blood, normalizing the albumin/globulin ratio. Provides normalization of the level of plasma transaminases, cholesterol, triglycerides, reducing the manifestations of dyslipidemia. Reduces bilirubin and alkaline phosphatase levels. Increases the liver's ability to store glycogen.

Improves the colloidal properties of bile, prevents the formation of gallstones. Improves the contractile function of the gallbladder.

Stimulates hematopoiesis.

In case of alcoholic liver damage, the drug reduces the level of ethanol in the blood and urine; increases the activity of acetaldehyde dehydrogenase, which helps reduce the level of acetaldehyde; prevents the binding of acetaldehyde to cell proteins and accelerates its elimination. By preventing the damaging effect of acetaldehyde on hepatocytes, the drug reduces the risk of developing a “hangover” syndrome.

Prickly caper root powder + Chicory seed powder + Iron oxide (mandur basma) + Black nightshade powder + Terminalia arjuna bark powder + Western cassia seed powder + Yarrow herb powder + Tamarix Gali powder + Steamed extracts from a mixture of medicinal raw materials: eclipta white, Philanthus niruri, Berhavia spreading, Tinospora cordifolia, Radish sativum, Emblika officinalis, Ceylon giltweed, Currant embelia, Terminalia hebula (myrobalan tree), Fumyana officinalis + excipients (Liv 52 tablets).

Prickly caper root extract + Common chicory seed extract + Black nightshade extract + Terminalia arjuna bark extract + Occidental cassia seed extract + Common yarrow herb extract + Tamarix Gali extract + Steamed aqueous extract (1:10) from a mixture of medicinal raw materials (taken in equal quantities of 0.64 mg): Eclipta alba, Philanthus niruri, roots of Berhavia spreading, stems of Tinospora cordifolia, seeds of radish, fruits of Emblica officinalis, roots of Ceylon vinum, fruits of Embelia currant, peel of Terminalia hebula fruits, fumaria officinalis + excipients (Liv drops 52 K).

The therapeutic effect of Liv 52 is due to the combined action of its components, so kinetic observations are not possible.

acute and chronic infectious, toxic and drug-induced hepatitis; liver cirrhosis in adults; fatty hepatosis; anorexia; prevention of toxic liver damage (caused by antibiotics, anti-tuberculosis drugs, antipyretics).

Release forms

Drops for oral administration Liv 52 K (sometimes mistakenly called syrup).

Instructions for use and dosage regimen

For preventive purposes, the drug is prescribed 2 tablets 2 times a day.

For therapeutic purposes, children over 6 years of age are prescribed 1-2 tablets 2-3 times a day, adults - 2-3 tablets 2-3 times a day.

The drug in the form of drops is prescribed for therapeutic and prophylactic purposes for children over 2 years old, 10-20 drops 2 times a day, for adults - 80-160 drops (1-2 teaspoons) 2 times a day.

Side effect

allergic reactions; dyspepsia. hypersensitivity to the components of the drug; pregnancy; lactation.

Use during pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy and lactation.

Use in children

For therapeutic purposes, children over 6 years of age are prescribed 1-2 tablets 2-3 times a day.

The drug in the form of drops is prescribed for therapeutic and prophylactic purposes to children over 2 years old, 10-20 drops 2 times a day.

special instructions

The drug should be prescribed with caution to patients with acute diseases of the stomach and intestines.

Liv 52 K (dosage form - drops) does not contain ethyl alcohol (alcohol) and can be used in children with diseases of the liver and biliary tract.

Drug interactions

Drug interactions with Liv 52 have not been described.

Analogues of the drug Liv 52

The drug Liv 52 has no structural analogues for the active substance.

Analogs by pharmacological group (hepatoprotectors):

D, L-Methionine; L-Methionine; S-Adenosylmethionine; Alpha lipoic acid; Antraliv; Berlition; Betaine citrate UPSA; Brenziale forte; Vitanorm; Gepa Merz; Hepatosan; Hepatofalk planta; Heptor; Heptral; Geptrong; Glutargin; Glutargin alkocline; Cawehol; Karsil; Karsil Forte; Cryomelt MN; L-ornithine-L-aspartate; Legalon 140; Legalon 70; Livodex; Livolife Forte; Lipoic acid; Lipoid PPL 400; Lipoid C 100; Maxar; Methionine; Metrop GP; Mylife; Molixan; Octolipen; Ornitsetil; Result Pro; Silegon; Silibinin; Silimar; Silymarin; Silymarina Sediko; Sirepar; Thiolipon; Thiotriazolin; Tykveol; Urdoxa; Urso 100; Ursodez; Ursodeoxycholic acid; Ursodex; Ursolive; Ursor; Ursosan; Ursofalk; Phosphonciale; Hepabos; Choludexan; Betaine Citrate Bofur; Exhol; Erbisol; Espa Lipon; Essentiale N; Essentiale forte N; Essential phospholipids; Essliver.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps and look at the available analogues for the therapeutic effect.

Liv-52 is a multicomponent drug that has a hepatoprotective effect, which is determined by the individual properties of each herbal ingredient included in its composition. What components are included in this complex drug?

Tablet form:

Chicory (dry extract); Caper bark; Nightshade; Terminalia arjuna; Cassia occidentalis; Tamarix gallicis; Yarrow seed; Iron oxide. Chicory seed extract; Caper bark; Nightshade; Terminalia arjuna; Cassia occidentalis; Tamarix gallicis; Yarrow seed.

What does Liv-52 help with? As a hepatoprotector, the drug protects hepatocytes from damage and promotes their active regeneration. In addition, Liv-52 increases the activity of the biosynthetic function of liver cells, inhibits the oxidation of lipid components, protecting cell membranes from the negative effects of oxidation products on them. The action of the drug is also aimed at binding toxins and other harmful substances that have entered the body and negatively affect the functions of hepatocytes. The drug Liv-52 successfully combats congestion in the biliary tract, eliminating dyskinesia and normalizing the digestive process, increasing the patient's appetite. To the above properties of the drug you can also add choleretic, antioxidant and mild diuretic effects.

Main indications for use of Liv-52:

Diffuse liver damage (prevention and treatment); Toxic lesions of hepatocytes; Fatty liver degeneration; Hepatitis of various origins; Prevention of liver damage during the period of taking chemically aggressive medications, for example, antitumor drugs, antibiotics, etc.; Prevention of liver damage during radiological treatment (irradiation); Dyskinesia of the bile ducts; Cholecystitis, cholecystocholangitis; Paraproteinemia (presence of functionally defective proteins in the blood); Anorexia, weight loss in children.

Contraindications to taking the drug

Contraindications to treatment with Liv-52 are hypersensitivity to any ingredient of the drug, pregnancy and breastfeeding. The drug is not recommended for use in children under five years of age.

If during treatment with Liv-52 any allergic manifestations are observed - rashes, itching, skin hyperemia, or diarrhea occurs, then you must immediately stop using the drug and consult your doctor about the possibility of further continuing the course.

How to take Liv-52 correctly

Tablets: Adult patients are recommended to take two to three tablets 3-4 times a day. For children over six years of age, the dosage is one or two tablets, also 3-4 times a day. Like all homeopathic remedies, Liv-52 is taken either half an hour before meals or an hour after it. For the purpose of prevention, it is enough to take the drug twice a day, two tablets.

Liquid: for adult patients, take 80 to 160 drops of the drug (1-2 teaspoons) twice a day. Preventive dose – 80 drops per day at a time. Children from six years old – 10-20 drops twice a day.

Interaction with other medications

Before starting treatment with Liv-52, you must carefully read the instructions for its use in order to prevent adverse events in the form of adverse reactions of the body to this drug. The following factors should be taken into account:

The combination of Liv-52 with ibuprofen reduces the therapeutic effect of the latter; Using the drug together with tetracycline antibiotics reduces their effectiveness; Drinking alcohol is not recommended during the course of treatment.

Cost and analogues

The price of Liv-52 ranges from 280-350 rubles. You can get accurate information about how much the drug costs immediately before purchasing from the pharmacy chain in your locality.

In any case, due to certain factors, the patient has the opportunity to choose for himself a suitable analogue of Liv-52:

Hepatophyte; Gepabene; Karsil; Essentiale; Rezalut about; Antral; Enerliv; Heptral and others.

Reviews from experts

It should be noted that reviews of Liv-52 are quite contradictory. A number of specialists highly appreciate the therapeutic properties of this drug, while other hepatologists are skeptical about it. There is information in the medical literature that the properties of Liv-52 declared by the manufacturer do not correspond to reality. If clinical trials of the drug for the treatment of viral hepatitis demonstrated a decrease in bilirubin levels and a slight loss of body weight in patients, then during the treatment of alcoholic hepatitis the effect of using Liv-52 was almost equal to placebo. In addition, the intoxication indicator of the drug was also not noted.

Experts also refer to some cases of the use of Liv-52 in acute pathological conditions of the liver, when there was a significant deterioration in the patient’s condition. The use of the drug for liver failure had no effect on the mortality rate of patients, and in some cases even worsened it.

Taking into account all of the above, it is advisable before using Liv-52 to consult with your doctor and strictly follow his recommendations.

Price from 280 to 350 rubles.

Compound

One Liv 52 tablet contains: 65 mg of root powder prickly capers, 65 mg seed powder common chicory, 33 mg iron oxide, 32 mg powder black nightshade, 32 mg bark powder arjuna terminalia, 16 mg seed powder Western Cassia, 16 mg herb powder common yarrow, 16 mg powder Gali tamarix.

The specified ingredients are treated with steam extract from a mixture of the following medicinal raw materials: Philanthus niruri, radish sativum, berhavia, Tinospora cordifolia, Ceylon giltweed, Eclipta alba, Emblica officinalis, Terminalia chebula, Embelia currant, Fumitaria officinalis.

Additional substances: microcrystalline cellulose, magnesium stearate, sodium carboxymethylcellulose, croscarmellose sodium.

One milliliter of Liv 52 K contains: 17 mg of prickly caper extract, 17 mg of seed extract common chicory, 8 mg extract black nightshade, 8 mg bark extract arjuna terminalia, 4 mg seed extract Western Cassia, 4 mg herb extract common yarrow, 4 mg extract Gali tamarix.

These ingredients are steamed with an extract from a mixture of the following medicinal raw materials: Philanthus niruri, radish sativum, Tinospora cordifolia, Berhavia prostrata, Ceylon vinaria, Eclipta alba, Emblicus officinalis, Terminalia chebula, Embelia currant, Fumyaria officinalis.

Additional substances: sodium propylparaben, sodium citrate, sucrose, sodium methylparaben, water, peach flavor.

Release form

Green-gray biconvex round tablets with inclusions. 100 tablets in a plastic bottle - one bottle in cardboard packs. Dark brown drops for oral use. 60 ml in a dark glass bottle - one bottle with a dispenser pipette in a cardboard box.

pharmachologic effect

Hepatoprotective, choleretic action.

Pharmacodynamics and pharmacokinetics

Combined herbal medicine. It has antitoxic, hepatoprotective, choleretic, anti-inflammatory, antianorexic, antioxidant effects. Promotes the absorption of food and stimulates the digestion process. The hepatoprotective effect is due to the membrane-stabilizing and antioxidant properties of the drug components. The drug increases the content endogenous tocopherols in liver cells and concentration cytochrome P450. Stimulates the production of phospholipids and proteins. Helps restore hepatocytes, inhibits fatty, degenerative and fibrotic changes, activates intracellular metabolism.

The drug normalizes plasma protein levels blood regulating the attitude globulins And albumin. Provides normalization of concentration triglycerides, cholesterol, plasma transaminases, suppressing manifestations dyslipidemia. Lowers the level alkaline phosphatase And bilirubin. Increases the liver's ability to store glycogen.

In case of alcoholic damage to liver tissue, the drug lowers the level ethyl alcohol in urine and blood; enhances activity acetaldehyde dehydrogenase, which accelerates the decrease in concentration acetaldehyde; stops the reaction acetaldehyde with cell proteins, accelerates its evacuation from the body. Preventing damaging effects acetaldehyde on liver cells, the drug reduces the risk of “hangover” syndrome.

Improves colloidal indicators of bile, prevents the production of gallstones. Stimulates gallbladder peristalsis and hematopoiesis.

Indications for use

The following are indications for use of Liv 52:

toxic, infectious and medicinal hepatitis acute and chronic; fatty hepatosis; cirrhosis of the liver in adults; anorexia; prevention of toxic changes in the liver (caused by anti-tuberculosis drugs, antibiotics, antipyretics).

Contraindications

Pregnancy or lactation. Hypersensitivity to the components of the drug.

Side effects

Skin reactions: edema skin, rash, hyperemia, itching, skin reactions, including epidermal toxic necrolysis. Digestive reactions: nausea, dyspeptic symptoms, loose stools. When using the drug, it is possible to develop hypersensitivity reactions.

Instructions for use of Liv 52 (Method and dosage)

The drug should be taken orally regardless of meals.

Liv 52 tablets, instructions for use

For preventive purposes, the medicine is taken 2 tablets twice a day. For therapeutic purposes, children over 6 years old take 1-2 tablets three times a day, and adult patients take 2-3 tablets up to three times a day.

How to take the drug in the form of drops?

The drug in the form of drops is taken for preventive and therapeutic purposes. Children over 2 years old are recommended to take 11-20 drops twice a day, adults - 82-160 drops (1 or 2 teaspoons) twice a day.

Overdose

There are no data on cases of drug overdose.

Interaction

Features of pharmacological interactions with other drugs have not been studied.

Terms of sale

Over the counter.

Storage conditions

Keep away from children. Store in a dry place at room temperature.

Best before date

special instructions

It is recommended to prescribe the drug with caution to patients with acute diseases of the digestive system.
Liv 52 does not contain ethyl alcohol and is approved for use in children with lesions of the biliary tract and liver.

Liv 52 in bodybuilding

The drug is often used in bodybuilding as hepatoprotector with long-term courses of drug and hormonal stimulation of muscle growth and athletic capabilities.

Analogues

Level 4 ATX code matches:

The most accessible analogues: Karsil, Bonjigar, VG-5, Hepa-Merz, Hepatoxan, Heptrong, Cryomelt MN, Laennec, Metrop GP, Gemaxol, Thiotriazolin, Phosphogliv, Hofitol, Silibinin, Silimar, Legalon, Essentiale.

Which is better: Karsil or Liv 52?

Karsil, like Liv 52, is a herbal preparation with similar pharmacodynamic parameters and indications for use. Patients have differing opinions about which drug is best, and there are no credible studies on the comparative effectiveness of these drugs. The choice must be made based on the doctor’s recommendations and individual sensitivity.

For children

For therapeutic purposes, children over 6 years old take Liv 52 1-2 tablets three times a day.

For therapeutic or prophylactic purposes, children over 2 years old take Liv 52 K, 11-20 drops twice a day.

During pregnancy and lactation

The drug is contraindicated for use during these periods.

Liv 52 is a plant-based drug that belongs to the group of hepatoprotectors. The main indication for its use is liver disease. The medicine has gained particular popularity as a means of helping to relieve hangover syndrome. Can Liv 52 be taken with alcohol?

Features of the composition

To understand how a medicine affects the body, you should carefully familiarize yourself with its constituent components. The active substances are:

herbaceous caper;
chicory;
hay leaves;
yarrow;
nightshade;
cassia occidentalis;
terminalia;
iron oxide.

Before becoming part of the drug composition, all components are processed, as a result of which microdoses of active compounds are formed. A characteristic feature of such microdoses is the possibility of adverse reactions.

The drug contains components that are harmful to the liver

Many patients are confused by the content of components such as hay, nightshade and caperberry in the drug. They are popularly known for their harmful effects on the liver. In addition, the composition includes chicory and yarrow, known for their choleretic effect. Terminalia also belongs to the choleretic substances, but it has an antioxidant function. When all these substances enter the body in small doses, they activate protective functions, namely, they stabilize cell membranes, block apoptosis and eliminate active radicals.

Long-term use increases protein production. This determines the anabolic effect of the drug. That is, during treatment, significantly more proteins are produced than those that undergo breakdown. This can be determined even by the patient’s appearance. He has an increase in muscle mass.

How the drug works

The medicine is a combination remedy due to the inclusion of a large number of plant components. One of the main components is capers, enriched with the following substances:

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steroid saponins;
ascorbic acid;
quercetin;
thioglycosides;
routine

Herbaceous capers have the following properties:

anesthetic;
diuretic;
hepatostimulating;
hepatoprotective;
increase appetite.

Western Cassia has choleretic, laxative, and antitoxic properties. It promotes the normal discharge of bile. The plant has a tonic effect on the gastrointestinal tract.

Terminalia is known for its diuretic properties. Yarrow is enriched with vitamin K, essential oils, and tannins. The plant helps to enlarge the bile ducts, which ensures the correct process of bile secretion. At the same time, there is no pain in the intestinal area, due to the fact that the plant has a tonic effect. These properties of the drug allow it to be used in the following cases:

peptic ulcer;
gastritis;
flatulence;
kidney diseases;
liver dysfunction;
ulcerative colitis.

Iron oxide ensures intensification of the circulatory system.

Alcohol addiction

Taking the drug stimulates improvement in the digestive system. Patients experience a decrease in the degradation of cell membranes and an increase in the concentration of antioxidants.

The antitoxic property plays a special role in chronic alcoholism. Prevents lipids from entering liver tissue. This vital organ acquires full protection from possible destruction in the future.
Correct use of the medicine leads to an increase in protein and restores liver functionality.

The combination of medicinal components is selected in such a way that the drug is able to act comprehensively. If a person often associates with alcohol, then taking this medicine is a direct indication for him.

Indications for use

Liv 52 can be used in treatment only if prescribed by a specialist. Despite the fact that the product consists almost entirely of plant components, it is necessary to exclude possible intolerance by the body. In this way, it will be possible to avoid the occurrence of a negative reaction to taking the medicine. The main indications for prescription are the following diseases:

Hepatitis with different forms of the disease.
Treatment and prevention of liver function. Lesions associated with ingestion of chemical irritants.
. Such cases include alcohol poisoning.
Cirrhosis of the liver.
Changes in the structure of the liver preceding the development of cirrhosis.
Pathological exhaustion, up to anorexia.
Hypoproteinemia.
Fatty hepatosis.
Sharp weight loss.
Rehabilitation therapy after surgery.
Rehabilitation after a course of chemotherapy.
Cholecystitis.
Biliary dyskinesia.

The following cases should be noted as contraindications:

Hypersensitivity to individual components of the drug.
Acute forms of gastrointestinal diseases (allowed, but with extreme caution).
Pregnancy period.
Lactation.

Combination of the drug with alcohol intake

This remedy is often used as a drug to relieve hangover syndrome. True, there has been little research on this topic in humans. But experiments carried out on animals show that during alcohol intoxication of the body, Liv 52 helps to reduce the activity of enzymes that destroy the liver. Thanks to this, the liver ceases to experience constant stress, and glutathione reserves are preserved and maintained. Thus, the drug plays a protective role in the oxidative process from alcohol. That is, we can conclude that there is compatibility between Liv 52 and alcohol.

All studies conducted speak exclusively of the positive effects of the drug. All patients note a significant improvement in their well-being, and severe hangover symptoms are suppressed. Such indicators also apply to those people who often drink alcohol.

If there are no contraindications for taking the drug, then it can be used in complex treatment, combined with other medications. If the therapeutic effect of the drug for hangover syndrome is insignificant, treatment can be supplemented with similar drugs.

The drug Liv 52 helps with alcohol poisoning

How does the drug affect alcohol poisoning?

The medicine has a large number of positive properties, which actively manifest themselves when relieving poisoning as a result of regular intake of alcohol. How does the drug affect the body when the body is poisoned?

Possible consequences

If a person has an individual intolerance to certain components of the drug, and he does not suspect it, then by taking the medicine, he can provoke allergic reactions, including severe attacks of suffocation. In addition, the digestive system and organs of the gastrointestinal tract will suffer. At the first suspicion of an adverse reaction of the body, you should immediately stop using the drug and contact a specialist for advice on replacing the medication.

There are cases where patients diagnosed with hepatitis develop epidermal necrolysis. The course of the disease can take different forms, but the most dangerous is if the symptoms are acute and difficult to treat.

Since the medication is contraindicated for use during pregnancy and lactation, there is no data on the use of the drug in the treatment of pregnant women. During this period of life, it is better to avoid this medication. If there is nothing to replace it with, and Liv 52 is the only salvation, the use of the drug is allowed with a change in dosage and under the strict supervision of the treating specialist.

Long-term use of the drug or its accidental overdose does not in any way affect the appearance of the effect of toxic poisoning. But this does not mean that it is permissible to allow unauthorized deviations from the medication regimen. To avoid side effects and serious consequences, you should strictly follow the instructions given by the doctor.

If the medicine is taken simultaneously with Ibuprofen, there is a noticeable decrease in the concentration of the latter.

Experts' opinion

Numerous reviews from doctors are quite contradictory. Some of them note the positive properties of the drug, while others are convinced of its low effectiveness. They cite its detrimental effects on the liver in some known treatment cases. During drug therapy with Liv 52, the condition of the liver worsened. But these are rather isolated cases, and such effects could have been facilitated by intolerance to the components of the drug, which was not known to doctors and patients.

High efficiency in relieving hangover syndrome and eliminating intoxication of the body has been proven many times. There is a rapid recovery of the patient's strength, and the structure of the liver improves.

Briefly: Liv-52 is a herbal remedy that has been used to treat hepatitis since the mid-20th century. Now the drug is positioned as a choleretic agent. The latest studies conducted according to the canons of evidence-based medicine do not find confirmation of the effectiveness of the drug (including for the treatment of alcoholic liver disease). But there may be side effects, so do not take Liv-52 without a doctor's recommendation.

Use of Liv-52 in the past and now

Liv-52 is a drug well known to domestic consumers. In the modern world, it was proposed for the treatment of viral hepatitis in 1955. The history of the use of Liv-52 in Soviet and then Russian practice in the treatment of diseases accompanied by liver damage goes back at least 40 years. In the United States, the drug is prohibited from being sold as a medicine.

On the other hand, the latest studies conducted according to the canons of evidence-based medicine do not find confirmation of the effectiveness of the drug and sometimes even demonstrate its danger.

Since its invention, the drug has undergone a kind of rebranding: if initially in the instructions for use Liv-52 was positioned as a classic hepatoprotector capable of completely or almost completely restoring damaged liver tissue, now it is spoken of mainly as a choleretic drug. Apparently, this is due to the complex composition of the drug and poor knowledge of its mechanism of action, the difficulty of conducting and interpreting the results of clinical trials. However, in this respect, it is no different from other hepatoprotectors of plant origin: in order to understand exactly how and what exactly they help with, people still have to study and research them.

We study the instructions for Liv-52. Composition and effect of the drug

In the instructions for Liv-52, the manufacturer calls the main components:

caper,
chicory,
iron oxide
nightshade,
yarrow,
terminalia
and senna (western cassia).

The main components enter the preparation after steaming the extract of about a dozen other plants. But such processing leads to the appearance of microdoses of other active substances of these plants along with the main components (the main difference between the action of microdoses and regular doses should be considered the possibility of the opposite effect).

When assessing the composition, attention is drawn to the presence of:

components toxic to the liver (nightshade, senna and caperberry)
and choleretic components (yarrow and chicory).

Terminalia, depending on the dose, can act as both a choleretic and an antioxidant agent. According to the advertisement, the intake of liver poisons in small doses simultaneously with antioxidants leads to the body actively engaging in protective reactions, including membrane stabilization, blocking apoptosis (programmed cell death) and neutralization of active radicals.

Subsequently, protein synthesis reactions in hepatocytes intensify, which determines the popularly known anabolic effect of Liv-52. This means that the synthesis of substances in the body begins to prevail over decay. This is primarily noticeable by weight gain, including due to muscle tissue and bones.

Will the liver protect against alcohol?

For readers of our site, the effect of the drug when drinking alcohol should be especially interesting. Separate experiments on animals have shown that in case of alcoholic liver damage, the use of Liv-52 can prevent the alcohol-induced increase in the activity of the enzymes gamma-glutamyl transpeptidase (GGTP) and superoxide dismutase (the activity of these enzymes increases with the destruction of working liver cells - hepatocytes).

This means that the load on the mechanisms that prevent the action of active radicals is reduced. And this, in turn, helps maintain glutathione reserves and suppress lipid peroxidation (the building material of cell membranes) in the liver and protect against oxidative stress.

However, there are no high-quality human studies confirming the benefits of Liv-52 in this case.

Is there any benefit for alcoholic liver disease?

Whether a person gets better or not depends on Liv-52. This is evidenced by the results of a study conducted by Sri Lankan scientists in 1998-1999: H. A. de Silva, P. A. M. Saparamadu, M. I. Tabrev and others.

The experiment involved 80 patients with alcoholic liver disease. Half of them were prescribed to take three Liv-52 tablets twice a day for 6 months. The other half of the patients (the control group) were assigned to take placebo in exactly the same order. The patients did not know which of them took Liv-52 and which took placebo.

Participants in the experiment underwent blood tests and liver function tests three times: at the very beginning, after a month and after 6 months of therapy. Age, amount of alcohol consumed and initial liver condition were approximately the same.

Scientists found that there was no significant difference either in the tests or in the well-being of the patients, regardless of whether they took Liv-52 or not. There were no side effects from the drug either. From this study, it can be concluded that the drug is ineffective for the treatment of alcoholic liver disease.

Is the drug safe?

A group of European scientists conducted a study in 1997, the results of which were not encouraging. They treated half of their patients with alcoholic hepatitis with the drug Liv-52 (given 1200 mg), and the remaining patients were given a placebo. By the end of the experiment, among those who received the placebo, 86% of patients remained alive. And among those receiving Liv-52 - only 74%.

The situation was even worse with the treatment of hepatitis C. During treatment, 22 of 23 patients receiving Liv-52 died. All of these cases were associated with liver failure or bleeding. While in the control group (who did not receive Liv-52), fewer people died: 3 out of 11.

Liv-52 is, first of all, a choleretic drug. About how to overcome a hangover with the help of choleretic drugs, whether you can drink alcohol if you have problems with bile flow, and what to do if you vomit bile during a hangover - about all this.

You can ask a hepatologist a question in the comments. Don't hesitate to ask!

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Composed of one Liv 52 tablets includes: 65 mg root powder prickly capers , 65 mg seed powder common chicory , 33 mg iron oxide , 32 mg powder black nightshade , 32 mg bark powder arjuna terminalia , 16 mg seed powder Western Cassia , 16 mg herb powder common yarrow , 16 mg powder Gali tamarix .

Additional substances: microcrystalline cellulose, magnesium stearate, sodium carboxymethylcellulose, croscarmellose sodium.

In one milliliter drug Liv 52 K contains: 17 mg prickly caper extract, 17 mg seed extract common chicory , 8 mg extract black nightshade , 8 mg bark extract arjuna terminalia , 4 mg seed extract Western Cassia , 4 mg herb extract common yarrow , 4 mg extract Gali tamarix .

Additional substances: sodium propylparaben, sodium citrate, sucrose, sodium methylparaben, water, peach flavor.

Release form

Green-gray biconvex round tablets with inclusions. 100 tablets in a plastic bottle - one bottle in cardboard packs.
Dark brown drops for oral use. 60 ml in a dark glass bottle - one bottle with a dispenser pipette in a cardboard box.

pharmachologic effect

Hepatoprotective , choleretic action.

Pharmacodynamics and pharmacokinetics

Combined herbal medicine. It has antitoxic, hepatoprotective, choleretic, anti-inflammatory, antianorexic, antioxidant action. Promotes the absorption of food and stimulates the digestion process. The hepatoprotective effect is due to the membrane-stabilizing and antioxidant properties of the drug components. The drug increases the content endogenous tocopherols in liver cells and concentration cytochrome P450 . Stimulates the production of phospholipids and proteins. Helps restore hepatocytes, inhibits fatty, degenerative and fibrotic changes, activates intracellular.

The drug normalizes the level of plasma proteins by regulating the ratio globulins And . Provides normalization of concentration triglycerides, plasma transaminases , suppressing manifestations dyslipidemia . Lowers the level alkaline phosphatase And bilirubin . Increases the liver's ability to store glycogen .

In case of alcoholic damage to liver tissue, the drug lowers the level ethyl alcohol in urine and blood; enhances activity acetaldehyde dehydrogenase , which accelerates the decrease in concentration acetaldehyde ; stops the reaction acetaldehyde with cell proteins, accelerates its evacuation from the body. Preventing damaging effects acetaldehyde on liver cells, the drug reduces the risk of “hangover” syndrome.

Improves colloidal indicators of bile, prevents the production of gallstones. Stimulates gallbladder peristalsis and hematopoiesis.

Indications for use

The following are indications for use of Liv 52:

toxic, infectious and medicinal hepatitis acute and chronic;
fatty hepatosis;
in adults;
anorexia;
prevention of toxic changes in the liver (caused by anti-tuberculosis drugs, antipyretics).

Contraindications

or .
Hypersensitivity to the components of the drug.

Side effects

Reactions from the outside skin: skin, rash, hyperemia , skin reactions, including epidermal toxic necrolysis.
Reactions from the outside digestion: nausea, loose stools.
When using the drug, it is possible to develop hypersensitivity reactions .

Instructions for use of Liv 52 (Method and dosage)

The drug should be taken orally regardless of meals.

Liv 52 tablets, instructions for use

How to take the drug in the form of drops?

Overdose

There are no data on cases of drug overdose.

Interaction

Features of pharmacological interactions with other drugs have not been studied.

Terms of sale

Over the counter.

Storage conditions

Keep away from children. Store in a dry place at room temperature.

Best before date

special instructions

Liv 52 in bodybuilding

The drug is often used in bodybuilding as hepatoprotector with long-term courses of drug and hormonal stimulation of muscle growth and athletic capabilities.

Analogues

Which is better: Karsil or Liv 52?

For children

For therapeutic purposes, children over 6 years old take Liv 52 1-2 tablets three times a day.

For therapeutic or prophylactic purposes, children over 2 years old take Liv 52 K, 11-20 drops twice a day.

During pregnancy and lactation

The drug is contraindicated for use during these periods.

Reviews about Liv 52

Patients characterize the drug Liv 52 extremely well. And reviews from specialists, mainly reviews from hepatologists and gastroenterologists, are less optimistic and indicate a weak evidence base and the presence of an effect only for unexpressed liver disorders.

Price of Liv 52 in the pharmacy, where to buy

The price of Liv 52 (tablets) No. 100 is 245-310 rubles. This is the standard price for Russia.

The price of Liv 52 of the same release form in Ukraine is approaching 114 hryvnia.

Buying this drug in the form of drops will cost approximately the same price.

Online pharmacies in Russia Russia
Online pharmacies in Ukraine Ukraine

Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university he headed the Council of the Student Scientific Society. Advanced training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".

Experience: Worked in a general medical network for 3 years as a surgeon (Vitebsk Emergency Hospital, Liozno Central District Hospital) and part-time as a district oncologist and traumatologist. Worked as a pharmaceutical representative for a year at the Rubicon company.

Presented 3 rationalization proposals on the topic “Optimization of antibiotic therapy depending on the species composition of microflora”, 2 works took prizes in the republican competition-review of student scientific works (categories 1 and 3).

NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug Liv 52, be sure to consult your doctor.

Alexsa | 20:15 | 11.09.2018

This drug helped me. I had to take it while taking oral contraceptives. OK, I took it for quite a long time and even a little pigmentation appeared. Then I went to the doctor to find out what the reason was and it turned out that this was an OK effect, but Liv 52 corrected the situation, the liver symptoms went away.

Claudia | 9:21 | 25.01.2018

My husband, having suffered hemolytic hepatitis, restored his liver with Liv 52, using it daily after illness for 2 years, and now 2 times a year. In the ward, the guys he was with had already died of cirrhosis, some after a year, some after 3 years, later the rest died, his liver was in excellent condition. He no longer trusts any drugs like him. And she also loves Chinese Cordyceps.