Hydrocortisone ointment - instructions for use, indications and reviews. Hydrocortisone ointment: hormonal or not (review of the drug, composition, reviews)

In 1 bottle - hydrocortisone sodium hemisuccinate powder 100 or 500 mg.

In 1 ml of suspension - hydrocortisone acetate 25 mg.

In 1 g of eye ointment - hydrocortisone acetate 10 mg or 25 mg.

Hydrocortisone Richter 1 ml contains hydrocortisone acetate 25 mg and lidocaine hydrochloride 5 mg.

Release form

Lyophilized powder in bottles for the preparation of a solution for intravenous and intramuscular injections of 100 mg and 500 mg, a solvent (alcohol) in ampoules is included.

Suspension in ampoules for intramuscular and intra-articular injections 2.5% 1 ml, 2 ml.

Ointment 1% for external use, 5, 15, 20 and 30 g in a tube.

Eye ointment 0.5% 3.5.10 g in tube.

Eye ointment Hydrocortisone POS 1%, and 2.5% in a tube.

Cream 1% in a tube of 10 ml.

Pharmacological action

Antiallergic , anti-inflammatory .

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Wikipedia defines hydrocortisone as a highly active adrenal hormone. It is similar to cortisone, but more active. It has a pronounced effect on the metabolism of carbohydrates, proteins and fats. In the liver, it enhances the deposition of glycogen and glucose synthesis, which activates the release of insulin. Increases blood glucose levels, retains sodium and water, and enhances the removal of calcium from the body.

Renders anti-inflammatory , antiallergic , anti-shock effect . Possesses immunosuppressive activity . Inhibits the development of lymphoid and connective tissue, reduces capillary permeability. IN medical practice natural hydrocortisone or its synthetic esters (acetate and sodium hemisuccinate) are used. Succinates and hemisuccinates dissolve in water and have a rapid but short-term effect when administered by injection. Acetates are suspensions insoluble in water.

Hydrocortisone acetate exhibits predominantly anti-inflammatory activity. Inhibits phospholipase A2, which leads to suppression of prostaglandin synthesis. Inhibits the migration of leukocytes macrophages and mast cells into the site of inflammation, suppresses proteolytic activity, delays the growth of fibroblasts. Inhibits the release of histamine. Reduces hypersensitivity reactions, exudative processes at the site of inflammation and hyperemia, has a slowly developing but long-lasting effect. It is used for introduction into soft fabrics and inside the joint. The effect of intra-articular injection is observed after 6-20 hours and lasts for several days and weeks. Local application of ointment suppresses inflammatory and allergic reactions anterior segment of the eye. In terms of anti-inflammatory activity, it is weaker.

Hydrocortisone hemisuccinate provides metabolic And anti-inflammatory effect. It is the drug of choice for acute adrenal insufficiency and other emergency conditions, with adrenogenital syndrome .

Pharmacokinetics

When administered intravenously, the effect is observed after 15 minutes. Binds to proteins by 40-90%. Metabolized in the liver. Excreted by the kidneys, T1/2 - 80-120 minutes. To maintain high concentrations in the blood it is administered every 4–6 hours. When administered intramuscularly, it is absorbed slowly (up to 48 hours). Penetrates well through mucous membranes. 70% is metabolized in the placenta.

Hydrocortisone ointment penetrates the epidermis and accumulates there. Slightly absorbed into the systemic circulation, providing systemic action. Absorption of the active substance increases when used over large areas, frequent use, when applied to the skin of the face and folds, under occlusive dressings. In children, absorption is more pronounced, and therefore is used in a limited area, not for long. With frequent use, the accumulation of the active substance in the skin increases. Biotransformed in the epidermis, absorbed into the systemic circulation, 90% binds to proteins, is metabolized in the liver, and excreted by the kidneys and bile.

Hydrocortisone ointment for eyes does not penetrate well through the cornea, but penetrates into the epidermis and mucosal epithelium. Penetration depends on the condition of the cornea and increases with inflammation or damage to the ocular mucosa.

Indications for use

Systemic application for replacement therapy and treatment of inflammatory processes:

• adrenal insufficiency;
• arterial hypotension ;
• cardiogenic and traumatic shock;
• thyrotoxic crisis ;
• hepatic coma ;
• collapse at Addison's disease ;
• status asthmaticus;
• serum sickness;
• hay fever ;
• swelling of the larynx;
• nephrotic syndrome;
• acute liver failure;
• exacerbation ulcerative colitis And Crohn's disease ;
• psoriatic And ;
• spicy gouty arthritis ;
• juvenile arthritis ;
• spondylitis ;
• glenohumeral periarthritis ;
• rheumatic carditis .

Intra-articular and periarticular administration:

• reactive ;
• spicy ;
• rheumatoid arthritis ;
• epicondylitis ;
• spicy tenosynovitis ;
• post-traumatic;
• carpal tunnel syndrome.

Local application of ointment:

• allergic dermatitis ;
• exfoliative dermatitis ;
• seborrheic dermatitis ;
• itchy dermatoses ;
• anogenital itching ;
• photodermatoses ;
• insect bites;
• prurigo ;
• erythroderma .

Application of eye ointment

• , blepharitis ;
• blepharoconjunctivitis ;
• eyelid dermatitis;
• and condition after suffering keratitis;
• (acute and subacute);
• iritis ;
• posterior uveitis And choroiditis ;
• thermal and chemical burns;
• condition after surgical interventions.

Contraindications

Hydrocortisone IV and IM is contraindicated for:

• hypersensitivity;
• severe course hypertension;
• Itsenko-Cushing's disease ;
• jade ;
• peptic ulcer ;
• acute psychosis;
• osteoporosis ;
• peptic ulcer ;
• active forms ;
• renal failure ;
• systemic mycoses ;
• post-vaccination period;
• up to 1 year of age.

This form of release is contraindicated during pregnancy.

Local use of ointment is contraindicated in:

• bacterial skin diseases;
• viral and fungal skin lesions;
• manifestations;
• skin tuberculosis ;
• ulcers and skin wounds;
• skin tumors;
• perioral dermatitis ;
• acne vulgaris ;
• post-vaccination period;
• under 2 years of age.

Prescribed with caution when diabetes mellitus , systemic disease tuberculosis . Use with caution on facial skin due to the possibility of side effects (telangiectasia , perioral dermatitis ), even after short-term use. To prevent infectious skin lesions, hydrocortisone ointment is recommended to be prescribed in combination with antibacterial and antifungal agents.

Eye ointment is not prescribed for:

• viral eye diseases;
• violation of the integrity of the cornea;
• tuberculosis, purulent and fungal eye infections;
• during vaccination;
• trachoma .

During pregnancy, local use is possible as prescribed by a doctor, if the expected effect outweighs the risk possible complications for the fetus. The duration of use in pregnant women should not exceed 7–10 days.

Side effects

Hydrocortisone in ampoules with intramuscular and intra-articular administration can cause:

• sodium and fluid retention;
• loss of potassium;
• congestive heart failure;
• heart rhythm disturbance;
• hypokalemic alkalosis ;
• steroid myopathy ;
• necrosis of the heads of the humerus and femurs;
• osteoporosis and pathological fractures;
• ulcerative lesions of the gastrointestinal tract;
• petechiae And ecchymoses ;
• promotion intracranial pressure;
• mental disorders;
• convulsions;
• immunosuppression;
• violation menstrual cycle;
• growth suppression in children;
• Itsenko-Cushing syndrome .

To reduce adverse reactions prescribe a diet rich in potassium and limited in sodium. Control blood pressure, blood sugar and clotting.

External use of Hydrocortisone ointment can cause:

• irritation at the site of application of the drug;
• hyperemia ;
• burning;
• itching and dryness;
• striae ;
• skin depigmentation;
• swelling;
• atrophic changes;
• hypertrichosis ;
• acne-like rash;
• secondary infectious lesions;
• telangiectasia.

At long-term use over large areas, systemic undesirable effects may occur, as a manifestation of the resorptive effect of the drug (suppression of the adrenal cortex, hyperglycemia , Cushing's syndrome , glucosuria ). To prevent infectious skin lesions, combination with antibacterial agents is necessary.

Hydrocortisone POS eye ointment, which has a higher content of active substance, causes:

• burning;
• redness of the sclera;
• dermatoconjunctivitis ;
• eczema eyelids ;
• secondary steroid glaucoma (with long-term use);
• corneal perforation (if its integrity is violated);
• addition of a secondary infection.

In this regard, the ointment can be used for up to 2 weeks.

Instructions for use of Hydrocortisone (Method and dosage)

Hydrocortisone ointment, instructions for use

Apply a thin layer to the affected areas of the skin 2-3 times a day. The duration of treatment is 6-14 days, and if the course is persistent, it is extended to 20 days. For hypertrophic manifestations, they are used under occlusive dressings, which are changed after 24-48 hours. If after a week of treatment there is no improvement, the use of the drug is stopped and further treatment agreed with the doctor. Avoid contact with eyes. Use with extreme caution on facial skin, as telangiectasia and atrophy may occur. For long-term treatment, a sodium-restricted diet is prescribed and sufficient quantity squirrel.

In children, suppression of the adrenal cortex develops more quickly, and the production of growth hormone is also reduced. Therefore, it is prescribed to children only under medical supervision. When used in children 1 year of age, limit the duration of treatment and do not use occlusive dressings. In cases where it is necessary to apply ointment to the face area under a bandage, the duration of treatment is limited to two weeks.

Unlike ointment, 1% cream (Nycomed) can be used for sunburn, photodermatitis and diaper rash in children. Can be used on the face.

Hydrocortisone eye ointment, instructions for use

Eye ointment is placed in the conjunctival sac behind the lower eyelid, and a 1-2 cm strip of ointment is applied 3 times a day. After the procedure, carefully close your eyes. The duration of treatment is up to two weeks and can be extended only as prescribed by a doctor.

Do not allow the tube to come into contact with the surface of the conjunctiva of the eye. Do not use contact lenses during treatment. When using drops simultaneously, the ointment is applied 15 minutes after instillation. When using the ointment for more than 2 weeks, intraocular pressure should be monitored.

Hydrocortisone suspension, instructions for use

Before use, shake the contents to obtain a homogeneous suspension. Hydrocortisone in ampoules is injected deep into the gluteal muscle 50-300 mg, maximum 1000-1500 mg per day. For life-threatening conditions, 150 mg is administered every 4 hours for the first two days, then after 8 hours. Children are prescribed 1-2 mg per kg of weight every 4 hours, the daily dose is up to 6-9 mg per kg of weight.

Adults and children over 14 years of age are given 5-50 mg into the joint cavity; children younger age 5-25 mg once a week. The course of treatment is 3-5 injections. The action begins within 6-20 hours and lasts several days or weeks.

Hydrocortisone Richter suspension containing hydrocortisone and lidocaine is injected only periarticularly or into the joint cavity. Adults 5-50 mg. Single dose children aged 3 months to 1 year with periarticular administration - 25 mg, up to 6 years - 25-50 mg, 6-14 years - 50 mg.

Repeated administration is carried out after 3 weeks. It is injected into the same joint no more than 3 times a year, since it affects adverse influence on hyaline cartilage. For tendinitis, the injection is made into the tendon sheath (it cannot be injected into the tendon).

Instructions for the drug in ampoules (bottles)

Lyophilized hydrocortisone hemisuccinate powder is dissolved in the supplied diluent and administered intravenously or intramuscularly. In acute conditions, intravenous hydrocortisone is prescribed. At the beginning, a dose of 100 mg is administered over 30 seconds, then increased to 500 mg within 10 minutes (according to the severity of the condition). The injections are repeated every 2-6 hours. High doses are prescribed until the condition stabilizes (usually 48-72 hours). Daily dose - 1000-1500 mg. Typically, 2/3 of the dose is administered in the morning, and 1/2 in the afternoon. If long-term corticosteroid therapy is necessary, switch to another drug that does not cause sodium retention. The dose for children is at least 25 mg per day.

Hydrocortisone sodium hemisuccinate powder, which is highly soluble in water, can be used for inhalation using a nebulizer. Technically this is feasible, but the action will not be local, but systemic. This must be taken into account, especially when inhalations with hydrocortisone are performed for children; the daily dose in this case should not exceed 25 mg of the drug. Do inhalation in the morning and evening, no more than 5 days.

Physiotherapeutic local treatment with hydrocortisone gives good results, increases efficiency and is often used in the complex treatment of many diseases.

Ultrasound with Hydrocortisone

Ultrasound has a pronounced analgesic, antispasmodic and anti-inflammatory effect, stimulates blood circulation, improves trophism. As a result, the consequences of hemorrhages, infiltrates, traumatic edema and exudates resolve faster. During ultrasound therapy, ointment or gel based medications are additionally used. Their use allows you to achieve therapeutic concentration in the problem area. A moving technique is used: the area is lubricated with 1% ointment and, pressing the vibrator head tightly, move it in a circle or longitudinal direction. Before starting the procedures, it is necessary to take into account contraindications for ultrasound with Hydrocortisone:

• systemic skin diseases;
• pustular lesions at the site of the procedure;
• skin cancer ;
• psychoneuroses ;
• pregnancy (second half);
• arterial hypertension III degree;
• expressed atherosclerosis ;
• heart rhythm disturbances;
• arterial hypotension ;
• frequent attacks angina pectoris ;
• thyrotoxicosis ;
• osteoporosis ;
• complicated peptic ulcer ;
• complicated myopia ;
• diabetes mellitus severe course.

Phonophoresis with Hydrocortisone

From a technical point of view, the procedure differs little from ultrasound exposure. In phonophoresis using high-frequency ultrasonic vibrations with an intensity of 800 to 3000 kHz, the medicinal substance is also injected into the damaged area. IN in this case a hydrocortisone suspension of 5 ml is used, myopia ;

syringomyelia .

It is worth considering general contraindications for physical procedures: cancer , bleeding, pregnancy.

Electrophoresis

This is a method of influencing the body with direct current and medicinal substances entered using it. The active electrode of the device acts on problem area, and the indifferent electrode is in the patient’s hand. During the procedure, the drug is used in ampoules.

Indications for hydrocortisone electrophoresis include:

• rheumatic diseases ;
• injuries;
• arthrosis ;
• bursitis And tendovaginitis ;
• dermatological diseases and their consequences in the form of scars (the external condition of the skin improves, scars are almost completely eliminated).

Overdose

Overdose with prolonged use of the drug intramuscularly or intravenously can manifest itself as suppression of the adrenal cortex, nausea and vomiting, hyperglycemia , bleeding, sodium and water retention, increased blood pressure, development Itsenko-Cushing syndrome , exacerbation of chronic infections.

With topical use of the ointment, an acute overdose is unlikely, but with prolonged use, symptoms may appear chronic overdose with systemic manifestations.
Treatment: symptomatic therapy, gradual withdrawal of the drug.

Interaction

The effect of the drug when administered intramuscularly or intravenously is weakened by barbiturates, antihistamines and antiepileptic drugs, and diuretics - they increase hypokalemia. The effect of hypoglycemic agents is reduced with this method of administration.

Use with NSAIDs increases the risk of ulcer formation and hepatotoxicity.

Hydrocortisone reduces blood concentrations of salicylates and activity hypoglycemic agents. Cardiac glycosides and diuretics increase hypokalemia. When prescribed with, heart failure appears.

Simultaneous use of eye ointment and drugs that cause increased intraocular pressure, contributes to a greater increase in intraocular pressure.

Terms of sale

Ointment and eye ointment are dispensed without a doctor's prescription.

Suspension for injection - according to prescription.

Storage conditions

Storage temperature for ampoules is 25°C, ointment 5-15°C.

Best before date

The drug in bottles and ampoules - 5 years.

Ointment - 3 years.

Analogs

Level 4 ATX code matches:

Reviews of Hydrocortisone

Ointments and creams containing corticosteroids have antiallergic, anti-inflammatory and antipruritic effects. What is Hydrocortisone ointment for and for what skin diseases is it used? This is primarily eczema, neurodermatitis, psoriasis, itchy and allergic dermatoses, skin manifestations of lupus erythematosus. Most often to hormone therapy resort only if other means are ineffective local treatment. Indeed, the use of this ointment gives a rapid anti-inflammatory effect; after a few days, itching and swelling disappear.

The active substance of the hormonal drug Hydrocortisone ointment is a glucocorticosteroid that has an anti-inflammatory, anti-allergic, anti-edematous effect, and also eliminates skin itching.

The product is used externally and has a number of side effects that everyone should be aware of.

Pharmacological action of the drug

The active ingredient of the product is a synthetic analogue of adrenal hormones. The ointment is available in two versions - for the eye with a concentration of 0.5% and for use on the skin - 1%.

The drug relieves the inflammatory reaction in the skin by reducing the migration of lymphocytes and leukocytes in the affected area and suppressing the production of prostaglandins - direct participants in inflammation and pain.

The next pharmacological effect of Hydrocortisone ointment is to eliminate itching and have an anti-exudative effect.

The product reduces collagen production and blocks fibroblast activity. Due to this, the risk of developing scars in the area of ​​inflammation and proliferation of connective tissue, for example, with psoriasis, is reduced.

Hydrocortisone ointment is effective for quickly eliminating swelling in acute allergic reactions. The drug retains moisture in the skin and has a keratolytic (softening) effect, so its use is effective for dry psoriatic and eczematous lesions.

After application, hydrocortisone accumulates in the granular layer of the epidermis, and here, and later in the liver, its metabolism (decomposition) begins. The substance is excreted with bile through the intestines and urine.

What is Hydrocortisone ointment used for?

The drug is used for local treatment of inflammatory and allergic skin pathologies. The instructions for use of Hydrocortisone ointment indicate the following indications:

• psoriatic lesions;
• contact and ;
• eyelid pathologies (blepharitis, conjunctivitis, keratoconjunctivitis, dermatitis);
• neurodermatitis;
• lichen planus verrucous;
• seborrhea;
• different forms of eczema.

Hydrocortisone ointment - Instructions for use

Apply a thin layer of ointment to the skin 2-4 times a day and rub in gently. If inflammatory infiltration occurs, then the product is used with an occlusive dressing - this is a hermetically sealed insulation of the skin from moisture and air.

The duration of the treatment course is 1-2 weeks, it can be changed at the discretion of the doctor depending on the severity and type of disease.

In the treatment of blepharitis and other eye diseases, 3 to 5 times a day, Hydrocortisone ointment is placed behind the lower eyelid, squeezing 1 cm of the product out of the tube. During application, you need to tilt your head back and then close your eyes.

If the ointment is injected into the conjunctival area, it is important to be careful not to touch the mucous membrane with the tube's nose.

A combination such as ultrasound with hydrocortisone ointment.

This procedure is called phonophoresis, it is effective in the treatment of post-burn scars, neuralgia, articular and gynecological pathologies, muscle atrophy, trophic ulcers, varicose lesions, diseases of the ENT organs, fractures tubular bones and painful injuries.

Hydrocortisone ointment for wrinkles

There are several theories of aging, and one of them says that age-related changes skin due to decreased production steroid hormones in the adrenal cortex. In this regard, many people are wondering whether it is possible to use Hydrocortisone ointment for wrinkles?

The fight against skin aging and anti-aging care require regularity, so the use of hydrocortisone for this purpose is not only unjustified, but also risky.

Using the ointment for 1-2 weeks will give a short-term effect, and a long period of use is fraught with at least an increase in wrinkles, and in the worst case – atrophy of the skin, disruption of work internal organs, diabetes and other systemic and endocrine problems.

To prolong youth, it is better to choose an integrated approach, including facial massage, the use of oils and special cosmetic creams, proper nutrition and taking vitamins.

Hydrocortisone ointment for children

For children, hydrocortisone ointment can be used starting from the age of two, but only as directed and under strict medical supervision. The duration of the course is also determined only by the doctor.

When applying the ointment, do not apply fixing or warming bandages, that is, it is unacceptable to enhance the absorption of hydrocortisone. Children under 12 years of age should not apply the product to the anus.

Children are often prescribed antibiotic or antifungal medications along with this drug. If within a week treatment with Hydrocortisone ointment does not bring results or at least relief, you should stop using it and consult a doctor.

IN childhood faster than in adults, suppression of the activity of the adrenal cortex and the production of growth hormones develops, so the use of any hormonal drugs must be carried out carefully.

Hydrocortisone ointment - analogues

List of analogues of Hydrocortisone ointment:

• Hydrocort;
• Courtade;
• Highton;
• Lokoid;
• Laticort;
• Hydrocortisone Nycomed;
• Akortin.

Side effects

If the drug is used as prescribed by a doctor and in strictly recommended dosages, it does not cause suppression endocrine system and development of complications. Otherwise, there is a high risk of developing allergic reactions.

Long term use side effects from Hydrocortisone ointment can be systemic due to disruption of the pituitary gland, adrenal cortex and hypothalamus.

Local side effects:

• from the skin - atrophy, stretch marks, fungal skin infections, acne, pigmentation disorders, hemorrhages and slow healing of wounds and injuries;
• from the eyes - cataracts, deterioration or loss of vision, secondary eye infections, increased intraocular pressure.

Systemic disorders:

• osteoporosis due to calcium leaching;
• cramps and muscle pain, heart failure due to potassium leaching;
• swelling due to sodium and water retention in the body;
• obesity;
• weakened immunity;
• excessive sweating;
• problems with digestion and liver function, steroid stomach ulcer;
• hypertension, thrombosis, tachycardia (accelerated heart rate).

Contraindications

The drug should not be used in case of individual intolerance to hydrocortisone and other glucocorticoids. Hydrocortisone ointment is also contraindicated for:

• tuberculosis of the eyes and skin;
• in the period after vaccination;
• skin cancer;
• under two years of age;
• viral, fungal and bacterial infections of the eyes and skin;
• impaired integrity of the skin (ulcers, wounds, abrasions) or eye epithelium;
• perioral dermatitis;
• acne vulgaris and;
• trachoma.

Storage

Hydrocortisone ointment should be stored in a place protected from children and animals at an air temperature of 10-20°C. The shelf life of the drug is 3 years.

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Characteristics of the substance Hydrocortisone

Hydrocortisone is a hormone secreted by the adrenal cortex and is a glucocorticoid. In medical practice for systemic and local application use natural hydrocortisone or its esters (hydrocortisone acetate and hydrocortisone sodium hemisuccinate).

Hydrocortisone is a white or almost white powder, odorless and bitter taste. Solubility (mg/ml) at 25 °C: water 0.28; ethanol 15.0; methanol 6.2; acetone 9.3; chloroform 1.6; propylene glycol 12.7; ether - about 0.35. Dissolves in concentrated sulfuric acid to form a fluorescent solution of intense green color. Molecular weight 362.47.

Hydrocortisone acetate is a synthetic steroid, white or white with a slightly yellowish tint, odorless crystalline powder. Slightly hygroscopic. Solubility in water: 1 mg/100 ml, in ethanol: 0.45 g/100 ml, in methanol: 3.9 mg/ml, in acetone: 1.1 mg/g, in ether: 0.15 mg/ml , in chloroform: 1 g/200 ml, soluble in dimethylformamide, soluble in dioxane. Molecular weight 404.50.

Hydrocortisone sodium hemisuccinate is a synthetic steroid, white or white with a slightly yellowish tint porous mass or amorphous hygroscopic white powder; solubility in water is approximately 500 mg/ml. Easily soluble in methanol, ethanol, slightly soluble in chloroform. Molecular weight 484.51.

Hydrocortisone 17-butyrate - molecular weight 432.55.

Pharmacology

Pharmacological action- anti-inflammatory, antiallergic, immunosuppressive, antipruritic, antishock, antiexudative, glucocorticoid.

Inhibits hypersensitivity reactions, proliferative and exudative processes in connective tissue, at the site of inflammation. Reduces local hyperemia and hyperthermia of the skin. The action is mediated through specific intracellular receptors. Prevents the activation of phospholipase A 2, stimulating the formation of its inhibitor - lipomodulin and, as a result, direct impact on cell membranes, disrupts the synthesis of PG and the release of macrophage chemotactic factor, inhibits the activation of tissue kinins. Reduces the migration of macrophages and lymphocytes to the site of inflammation. Blocks Fc receptors on the surface of macrophages for IgG and C3 complement components. Stabilizes lysosome membranes, preventing the release of lysosomal enzymes. Suppresses alteration, exudation and proliferation. In large doses, it inhibits the development of lymphoid and connective tissue, inhibits the activity of hyaluronidase, and reduces capillary permeability. Inhibits the production of collagenase and activates the synthesis of protease inhibitors. Blocks the synthesis and release of histamine and other biological substances from sensitized mast cells and basophils active substances, suppresses various stages immunogenesis without exerting a mitostatic effect. Increases the level of glycogen in the liver, inhibits the release of sodium and water, and increases potassium. Affects protein (causes negative nitrogen balance due to increased catabolism) and lipid metabolism. Increases blood volume, tissue hydrophilicity, increases blood pressure, and has an anti-shock effect. The threshold dose leading to the development of Cushing's syndrome with long-term use is about 30 mg. With long-term use, atrophy of the adrenal cortex develops, the formation of ACTH and thyroid-stimulating hormone of the pituitary gland is inhibited.

Hydrocortisone acetate is characterized by a slowly developing, but longer lasting effect than that of water-soluble drugs. Used for administration to sites of injury, joints and soft tissues, where it has a local anti-inflammatory effect, although the development of systemic effects is possible hormonal effects. Therapeutic effect when administered intra-articularly, it occurs within 6-24 hours and lasts from several days to several weeks. Hydrocortisone sodium succinate has both metabolic and anti-inflammatory activity. After intravenous administration, the effect appears after 1 hour, its duration varies. Excretion of the administered dose is carried out within 12 hours. If it is necessary to maintain high plasma concentrations, administration is recommended every 4-6 hours. This hydrocortisone salt is quickly absorbed and, with intramuscular administration, is excreted in the same way as with intravenous application.

Well absorbed after oral administration. Cmax is reached after 1 hour. After intramuscular administration, absorption occurs slowly (24-48 hours). It binds to plasma transcortin by 70-80%, to albumin by 10%, about 10% is in the form of a free fraction. Penetrates well through mucous membranes and histohematic barriers. Metabolized in the liver. It is excreted primarily through the kidneys in the form of inactive metabolites. About 70% of hydrocortisone is metabolized in the placenta to form the inactive 11-keto form.

When used, ophthalmic ointment (in the form of hydrocortisone acetate) does not penetrate well through the cornea into the intraocular fluid, but penetrates into the epidermis and epithelium of the mucous membrane. After application to the skin (in the form of hydrocortisone acetate and hydrocortisone 17-butyrate), it accumulates in the epidermis. IN small degree can be absorbed through the skin and have a systemic effect. The absorbed portion is metabolized in the epidermis and then in the liver. Metabolites and a small part of hydrocortisone are excreted in urine or bile.

Use of the substance Hydrocortisone

For systemic use: acute allergic reactions, severe attack bronchial asthma, asthmatic condition, serum sickness, hypersensitivity reactions to drug administration; emergency conditions- hypotension, incl. orthostatic, collapse in Addison's disease, myocardial infarction, hemorrhagic stroke, Morgagni-Adams-Stokes syndrome, coma due to cerebrovascular accident and inflammatory diseases brain, hypothyroid and hepatic coma, multiple bleeding, acute liver failure in case of poisoning, laryngeal edema in allergic and inflammatory lesions, burns and injuries, poisoning with vitamin D, strong acids, organophosphorus substances, quinine, chlorine, post-transfusion complications, Mendelssohn's syndrome, snake bites and scorpions; anaphylactic, hemorrhagic, cardiogenic and traumatic shock; endocrine diseases- Waterhouse-Friderichsen syndrome, primary or secondary adrenal insufficiency (preferably natural cortisone and hydrocortisone, synthetic analogues should be used in combination with mineralocorticoids), adrenogenital syndrome with sodium loss, thyroiditis; hypercalcemia associated with cancer; rheumatic diseases- psoriatic, rheumatoid, juvenile and acute gouty arthritis, ankylosing spondylitis, acute and subacute bursitis, glenohumeral periarthritis, systemic lupus erythematosus, acute rheumatic carditis, dermatomyositis; sarcoidosis, Loeffler's syndrome, berylliosis, fulminant or disseminated pulmonary tuberculosis, aspiration pneumonitis (in combination with specific chemotherapy); idiopathic thrombocytopenic purpura in adults, autoimmune hemolytic and congenital hypoplastic anemia, erythroblastopenia, palliative care leukemia and lymphomas in adults, acute leukemia in children; nephrotic syndrome without signs of uremia (to reduce proteinuria and induce diuresis), severe exacerbations of ulcerative colitis and Crohn's disease, tuberculous meningitis with subarachnoid block, trichinosis with neurological and myocardial manifestations, acute manifestations multiple sclerosis, disseminated lung cancer (additional therapy), differential diagnosis of idiopathic and drug-induced leukopenia.

Intra-articular and periarticular administration(hydrocortisone acetate): reactive synovitis (including with deforming osteoarthritis), rheumatoid arthritis, acute and subacute bursitis, acute gouty arthritis, epicondylitis, acute nonspecific tenosynovitis, carpal tunnel syndrome, post-traumatic osteoarthritis.

When applied to skin: inflammatory and allergic diseases skin of non-microbial etiology, incl. eczema, dermatitis (allergic, atopic, bullous herpetiformis, exfoliative, seborrheic, contact); pruritic dermatoses, photodermatoses, anogenital itching, insect bites, pemphigus, erythroderma, psoriasis.

In ophthalmology(hydrocortisone acetate as eye ointment): allergic conjunctivitis, blepharitis, eyelid dermatitis, keratitis, restoration of corneal transparency and suppression of neovascularization after keratitis, chemical and thermal burns(after complete epithelization of the cornea); iritis, iridocyclitis, inflammation of the anterior segment, diffuse posterior uveitis and choroiditis, sympathetic ophthalmia, condition after surgery.

V/c for keloids, localized hypertrophic, infiltrative, inflammatory damage, lichen planus, psoriatic plaques, granuloma annulare, neurodermatitis, discoid lupus erythematosus, diabetic necrobiosis lipoidica, alopecia areata, cystic tumors aponeurosis and tendons.

Contraindications

Hypersensitivity (for short-term systemic use for health reasons is the only contraindication).

For intra-articular and periarticular use: previous arthroplasty, conditions after intestinal anastomosis, pregnancy, breastfeeding.

When applied to skin: bacterial, viral and fungal skin diseases, skin manifestations of syphilis, skin tuberculosis, skin tumors, loss of integrity skin(ulcers, wounds), rosacea, acne vulgaris, perioral dermatitis, post-vaccination period, pregnancy, breastfeeding.

For eye ointment: purulent, viral, tuberculous and fungal eye diseases, trachoma, primary glaucoma, disruption of the integrity of the corneal epithelium; vaccination period, pregnancy, breastfeeding.

Use during pregnancy and breastfeeding

The use of corticosteroids during pregnancy is possible if the expected effect of therapy outweighs the potential risk to the fetus (adequate and strictly controlled safety studies have not been conducted). Women of childbearing age should be warned of the potential risk to the fetus (corticosteroids cross the placenta). It is necessary to carefully monitor newborns whose mothers received corticosteroids during pregnancy (adrenal insufficiency may develop in the fetus and newborn). Should not be used frequently, in large doses, for a long period of time long period time.

Breastfeeding women are advised to stop either breastfeeding or the use of drugs, especially in high doses (corticosteroids penetrate into breast milk and may inhibit growth, the production of endogenous corticosteroids and cause adverse effects in the newborn). When using external forms of hydrocortisone, do not apply the drug to the skin of the breast.

Side effects of the substance Hydrocortisone

The incidence and severity of side effects depend on the method, duration of use, dose used and the ability to comply with the circadian rhythm of drug administration.

Systemic effects

From the side of metabolism: retention of Na + and fluid in the body, hypokalemia, hypokalemic alkalosis, negative nitrogen balance, hyperglycemia, glucosuria, weight gain.

From the endocrine system: secondary adrenal and hypothalamic-pituitary insufficiency (especially during stressful situations such as illness, injury, surgery); Cushing's syndrome; growth suppression in children; menstrual irregularities; decreased tolerance to carbohydrates; manifestation of latent diabetes mellitus, increased need for insulin or oral antidiabetic drugs in patients with diabetes mellitus.

From the outside cardiovascular system and blood (hematopoiesis, hemostasis): increased blood pressure, development (in predisposed patients) or increased severity of chronic heart failure, hypercoagulation, thromboembolism, ECG changes characteristic of hypokalemia; in patients with acute and subacute infarction myocardium - spread of necrosis, slowing down the formation of scar tissue with possible rupture of the heart muscle, obliterating endarteritis, hematological changes.

From the musculoskeletal system: muscle weakness, steroid myopathy, loss muscle mass, osteoporosis, compression fracture spine, aseptic necrosis the heads of the femur and humerus, pathological fractures of long tubular bones, ruptures of tendons, primarily the Achilles.

From the gastrointestinal tract: steroid ulcer with possible perforation and bleeding, pancreatitis, flatulence, ulcerative esophagitis, indigestion, nausea, vomiting, increased/decreased appetite; after treatment with corticosteroids, an increase in the levels of ALT, AST and alkaline phosphatase in the blood serum was observed; Usually these changes are minor and are not associated with any clinical syndromes and are reversible after cessation of treatment.

From the skin: atrophic streaks, acne, delayed wound healing, thinning of the skin, petechiae and ecchymosis, erythema, increased sweating.

From the nervous system and sensory organs: convulsions, increased intracranial pressure with congestive nipple syndrome optic nerve(pseudotumor cerebri - more common in children, usually after reducing the dose too quickly, symptoms - headache, decreased visual acuity or double vision); vertigo, headache, malaise, mental disorders; formation of posterior subcapsular cataract, increased intraocular pressure, glaucoma; steroid exophthalmos.

Allergic reactions: generalized (allergic dermatitis, urticaria, anaphylactic shock) and locals.

Others: masking symptoms infectious diseases, withdrawal syndrome; reactions at the injection site - burning, numbness, pain, paresthesia and infection, hyper- or hypopigmentation, scarring; skin atrophy and subcutaneous tissue, sterile abscess.

When applied to the skin: irritation, burning, dry skin, local allergic reactions, incl. hyperemia, swelling, itching; with long-term use, especially under impermeable dressings or on large areas of skin - systemic side effects; steroid acne, purpura, telangiectasia; development of hypercortisolism as a manifestation of a resorptive effect (in these cases the drug is discontinued); with long-term use, it is also possible to develop secondary infectious skin lesions, atrophic changes, and hypertrichosis.

Eye ointment: allergic reactions, burning, scleral injection, increased intraocular pressure, exophthalmos; if the integrity of the corneal epithelium is violated, delayed healing and perforation of the cornea are possible; with long-term use, the development of steroid glaucoma is possible; frequent repeated courses of treatment can lead to the formation of posterior subcapsular cataracts; addition of a secondary infection.

Interaction

Barbiturates, antiepileptics and antihistamines reduce effectiveness. NSAIDs increase the risk of ulceration in the gastrointestinal tract, paracetamol - hepatotoxicity. Hydrocortisone reduces the blood level of salicylates (increases clearance) and the activity of antidiabetic drugs, changes the effectiveness of anticoagulants. Cardiac glycosides and non-potassium-sparing diuretics potentiate hypokalemia, anabolic steroids increase tissue hydrophilicity. When combined with amphotericin B, the development of dilated myocardial damage and heart failure is possible.

Routes of administration

IV, IM, orally, intra-articularly and periarticularly, IV, locally.

Precautions for the substance Hydrocortisone

During the treatment period, vaccination is not recommended (due to the immunosuppressive effect of hydrocortisone). Intra-articular injection should be carried out under conditions of strict asepsis and antisepsis and only after excluding an infectious process in the joint. IM injection is made as deep as possible into the gluteal muscle to prevent the development of muscle atrophy. During long-term therapy, monitoring of potassium levels in the blood (and its administration) and regular ECG studies are recommended. To prevent the development secondary hypocortisolism caused by discontinuation of treatment, the dose should be reduced gradually. Glucocorticoids can mask some manifestations of the infectious process; new infections may occur due to a decrease in resistance. When treated with corticosteroids or in combination with other drugs that suppress cell, humoral immunity or the function of neutrophils, various viral, bacterial, fungal, protozoal infections and helminthic infestations that were previously latent can manifest themselves. The risk of infection and its more severe course increases in proportion to the increase in the dose of the drug.

Sudden cessation of treatment may cause the development of acute adrenal insufficiency; with long-term use, the drug should not be suddenly discontinued; the dose should be reduced gradually. In case of sudden cancellation after long-term use withdrawal syndrome may develop, manifested by increased body temperature, myalgia and arthralgia, and malaise. These symptoms can appear even in cases where there is no adrenal insufficiency.

Eye ointment. If, after application of the eye ointment, clarity of vision is temporarily lost, it is not recommended to drive a car or work with complex mechanisms immediately after application. During treatment you should refrain from wearing contact lenses. With excessive and frequent use of eye ointment during the day or its use in children, a systemic effect of hydrocortisone is possible (when the drug is discontinued, the symptoms go away on their own). When using other drugs in the form eye drops the time interval between their application and the use of the ointment should be at least 15 minutes. When using the ointment for more than 2 weeks and if there is a history of open- or closed-angle glaucoma, monitoring of intraocular pressure is necessary. Children are more likely to develop systemic effects of hydrocortisone than adults. In this regard, the ointment should be used in children, if possible, in short courses (5-7 days).

Forms for external use. For children under 12 years of age, the drug is prescribed only under strict medical supervision. When using the ointment in children over 1 year of age, it should be limited total duration treatment and exclude conditions leading to increased drug resorption (warming, fixing and occlusive dressings). Avoid contact of the ointment with the eyes. The drug should be used with extreme caution on the skin of the face due to the possibility of side effects (telangiectasia, atrophy, dermatitis perioralis

The instructions for Hydrocortisone ointment indicate that it fights problem skin, allergies, inflammatory eye lesions.

Hydrocortisone is used for acute skin diseases, as well as subacute ones.

But hydrocortisone acetate is a new remedy in the fight against wrinkles.

Indications for use - what helps

Hydrocortisone eye ointment is prescribed for superficial, non-infectious, as well as skin diseases sensitive to local glucocorticosteroids.

What does hydrocortisone ointment help with when used externally:

1. Psoriasis.
2. Eczema.
3. Dermatitis, including contact, seborrheic and atopic.

When using topical hydrocortisone eye ointment:

1. Inflammation anterior section eyes without damage to the cornea.
2. Allergic lesions with severe itching and swelling.
3. After injuries and postoperative interventions.

Eye ointment - hormonal or not

It should be classified as a group of synthetic glucocorticosteroid hormonal drugs. Suitable for local external use.

Main component this drug has the following effects:

• decongestant;
• antiallergic;
• anti-inflammatory;
• antitoxic.

After the product is applied to the skin, it is quickly absorbed into the systemic bloodstream, providing a rapid therapeutic effect.


Composition: main active ingredient – ​​acetate (1 gram), petrolatum (45 grams), lanolin (10 grams), pentaerythrityl dioleate (5 grams), stearic acid (3 grams), E218 (0.08 grams), E216 (0.02 grams), water (up to 100 grams).

The presence of glucocorticosteroid hormones in the composition indicates that hormonal ointment or not. Hydrocortisone is a hormonal ointment.

The drug has a characteristic odor and a whitish-yellow color palette.

When used, acetate accumulates in the skin in the granular layer of the epidermis. After accumulation, the excess is excreted through the kidneys and intestines.

The product can be stored for no more than 3 years after opening the package, at a temperature not exceeding 25 degrees. Available without a prescription.

How many days can you use for external use - instructions

The product is gently rubbed onto problem areas of the skin in a thin layer. The procedure is carried out a maximum of twice a day. To ensure better absorption, rub in with light massage movements.

The course of treatment can range from 6 to 14 days. If health improvements are observed, then the use of the ointment is reduced to 2-3 times every 7 days. If the use of the drug does not show positive results within 7 days, treatment is canceled.

Hydrocortisone ointment for eyes is placed in the conjunctival sac behind the lower eyelid, applied in a layer of 1-2 centimeters three times a day. After the procedure is completed, the eyes are closed.

The course of treatment is up to 14 days. An extension can only be prescribed by a doctor. How many days you can use depends on the severity of the problem and the doctor’s instructions.

The tube should not be allowed to come into contact with the surface of the conjunctiva of the eyes. During treatment use contact lenses prohibited.

If treatment is accompanied by the use of drops, then the ointment is applied after instillation after 15 minutes.

If the product is used for more than 14 days, it is strongly recommended to control eye pressure.

You should not stop using the ointment abruptly; drug withdrawal is carried out according to a certain scheme, which implies a reduction in use. Otherwise, dermatitis may develop, which is accompanied by redness of the skin and burning.

During pregnancy and lactation

To date, experts have not fully studied the effect of hydrocortisone ointment on the health of a pregnant woman and fetus. It is strongly recommended to avoid long-term treatment and high dosage. Otherwise there is a danger negative influence on the baby in the womb, as it tends to be absorbed into the bloodstream.

During breastfeeding, hydrocortisone should not be used, or lactation should be completed.

For children and babies

Hydrocortisone can be used on children from 6 months of age. It should be taken into account that folds, a diaper or a diaper, can have a similar effect to an occlusive dressing. It is also taken into account that children’s skin is not yet mature; the ratio of the skin to the child’s weight matters.

To reach positive result, for children the smallest dosage is sufficient. The course of treatment lasts no more than 7 days. Exceeding the dosage will lead to developmental and growth disorders.

What is it used for in the nose?

What is hydrocortisone nasal ointment used for? Hydrocortisone is also used to treat allergic runny nose, severe swelling and itching in the nasal cavities. It is applied in small quantities in a thin layer to the nose.

Release forms - 1%, 2.5%, 0.5% and Lokoid

The drug is available in the following dosage forms:

1. 1. Ointment for external use 1 percent, can be 5 grams and 10 grams.
   2. Eye ointment 0.5% in a tube can be 3 grams, 5 grams, 10 grams. 1% tube contains 2.5 grams.
   3. Locoid: 0.1%, lipocrem, emulsion (Locoid Crelo, lotion)

The drug arrives on pharmacy shelves in the form of aluminum tubes, which are placed in cardboard box. Instructions must be included.

Pharmacy analogues of this product

Analogs of hydrocortisone ointment are as follows:

1. 1. 1. Solu-Cortef. A white (almost white) powder, the main component of which is hydrocortisone. Prescribed for diseases of the endocrine system, skin, connective tissues, allergies, rheumatic and eye diseases, oncology.
      2. Pimafukort. Contains natamycin, neomycin and micronized hydrocortisone. The release form is cream and ointment. Prescribed for skin mycoses, dermatoses caused by fungal infection, secondary infections(candidiasis), otomycosis.
      3. Laticort. Available in the form of ointment, cream and lotion. Main active ingredient is hydrocortisone. Discharged when the following diseases: dermatitis (atopic and seborrheic), psoriasis, contact eczema, lichen (lichen planus). Recommended for various insect bites.
      4. Cortimycin. Available in the form of an ointment, the main component is hydrocortisone. Prescribed for the treatment of diseases of the organs of vision, for example, allergic conjunctivitis, keratitis, herpes, iritis, cyclitis, chemical burn. The drug can be used as prophylactic after surgery.

Interaction with other drugs

Interaction of hydrocortisone with various drugs may be fraught with consequences:

1. 1. 1. Use with cardiac glycosides increases the toxicity of the drug.
      2. When used with acetylsalicylic acid, elimination is accelerated and its concentration in the blood plasma decreases.
      3. Use with paracetamol increases the risk of developing hepatotoxic (liver) effects.
      4. Use with cyclosporine - the side effects of hydrocortisone increase.
      5. Use with ketoconazole also increases the side effects of hydrocortisone.

Hydrocortisone reduces the effect of hypoglycemic drugs. A large dose of the drug reduces the effect of somatotropin.

The information is general and informative. Before taking the drug, consultation with a specialist is necessary.

Use in cosmetology - facial ointments

Female representatives noticed hydrocortisone ointment for skin care. There are no such indications in the standard instructions, but this method of use still exists. Due to the fact that the main component of the drug is the hormone cortisol, it can moisturize the skin regardless of its type.

Hydrocortisone is responsible for water balance. Due to lack of moisture, the skin becomes flabby, its elasticity decreases significantly, which leads to the appearance of wrinkles.

Anti-wrinkle facial skin

Hydrocortisone saturates the facial skin with moisture, which helps smooth out wrinkles.

Method of use:

1. 1. 1. Before the procedure, the facial skin is cleansed with tonic or lotion.
      2. After the skin has dried, the product is applied to it in a very thin layer.
      3. It is recommended to apply the procedure twice a day (in the morning and before bed). The course should not exceed 10 days. You can repeat it at least in a month.

Some female representatives compare the use of ointment with a Botox injection.

Experts do not approve of this method of getting rid of wrinkles. First, hydrocortisone does not bring long-term results, but only helps for a short period of time.

Second, frequent use such a remedy may entail negative consequences, for example, atrophy of the epidermis. In cosmetology, professionals do not use this product for the skin; it can be used at home.

Helps with acne

Also very popular drug used to combat acne. The problem of rashes, acne can occur not only in adolescents, but also in adults (cause, for example, hormonal imbalance, stress).

Judging by the reviews, the result is quite good. The drug is applied in a small amount (spot application) to the affected area before bedtime.

Possible side effects

Thanks to repeated observations, we can conclude that hydrocortisone ointment can cause the following side effects:

1. 1. • itching at the site of application, burning sensation;
      • redness, most often caused by individual intolerance;
      • glaucoma;
      • cataract;
      • exophthalmos.

There have been cases of overdose, but they are extremely rare.

If you use the ointment for more than 10 days in a row, the following problems may appear:

1. 1. 1. The level of glucose in the blood increases.
      2. A woman's menstrual cycle may be disrupted.
      3. When the drug is used in pediatrics, growth retardation is no exception.
      4. Problems with the adrenal glands.
      5. Allergic reaction.
      6. The functions of the visual organs are impaired.
      7. Due to the long period of getting used to the drug, the wounds take a long time to heal.

Contraindications to the use of eye ointment

Hydrocortisone ointment is contraindicated in the following cases:

1. 1. 1. Tuberculosis of the skin.
      2. Oncology.
      3. Pregnancy.
      4. Skin ulcer.
      5. Acne.
      6. Colds (even cough and runny nose).
      7. Fungal infections of the skin.
      8. Individual intolerance to components.

Hydrocortisone ointment is a steroidal anti-inflammatory agent intended for application to the skin, treatment of the maxillary cavity, and external auditory canal.

The drug is similar to cortisone, but is more active. Mainly used for acute adrenal insufficiency, status asthmaticus, acute allergic reactions.

On this page you will find all the information about Hydrocortisone ointment: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews from people who have already used Hydrocortisone ointment. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

GCS for local use.

Conditions for dispensing from pharmacies

Dispensed without a doctor's prescription.

Prices

How much does Hydrocortisone ointment cost? Average price in pharmacies it is at the level of 37 rubles.

Release form and composition

The drug Hydrocortisone is available in several dosage forms:

• Hydrocortisone eye ointment;
• Bottles with powder for the preparation of solution for injection;
• Hydrocortisone ointment;
• Eye drops;
• Pills;
• Suspension for intramuscular and intraarticular injections.

Main active substance The drug is the hormone hydrocortisone.

Hydrocortisone ointment 1% is available in aluminum tubes of 3 or 5 g in a cardboard box with attached instructions.

Pharmacological effect

The active component, hydrocortisone acetate, when applied externally, has anti-inflammatory, immunosuppressive and antiallergic effects.

1. The anti-inflammatory effect is associated with inhibition of the production of inflammatory mediators, a decrease in the activity of leukocytes and macrophages - blood cells migrating to the site of inflammation, narrowing small vessels, a decrease in the release of fluid from the bloodstream and the formation of inflammatory edema.
2. The antiallergic effect includes suppression of the production of antibodies and the destruction of mast cell granules, the contents of which are the main mediators of allergy - histamine and leukotrienes.
3. The immunosuppressive effect is achieved by suppressing the activity immune cells blood - T and B lymphocytes, interferon, interleukins and other mediators, excessive production and pathologically enhanced work of which occurs during autoimmune processes.

Indications for use

The drug is used against skin diseases non-infectious nature. The drug helps against diseases:

• dermatoses;

Hydrocortisone eye ointment application:

• - inflammatory change mucous membrane of the eye - conjunctiva;
• blepharitis - inflammation of the eyelid;
• blepharoconjunctivitis - inflammation of the mucous membrane and eyelid;
• iritis - inflammation of the iris, acute and chronic forms;
• iridocyclitis - inflammation of the iris and ciliary body of the eye;
• keratitis - inflammation of the cornea;
• burns visual organ of any origin.

Contraindications

Hydrocortisone should not be taken if you are hypersensitive to its components, severe forms hypertension, Itsenko-Cushing's disease, psychosis, nephritis, osteoporosis, gastric ulcer and duodenum, active forms of tuberculosis in the absence of specific treatment, diabetes mellitus, systemic fungal diseases. The drug is not recommended to be taken after recent surgery.

Use during pregnancy and lactation

The use of the drug during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus. It is recommended to take the drug during pregnancy for no more than 7-10 days.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Instructions for use

The ointment is sold in two versions - for treatment of the eye mucosa (5%) and for application to the skin (1%). Use medications strictly according to instructions, after consulting with your doctor. Features of use are described below medicines for the treatment of diseases.

1. Ointment 1%. Apply the drug spotwise for acne, or locally, spreading a thin layer directly onto the affected area, then wash your hands. Use the product 2-3 times during the day. The duration of treatment depends on the characteristics of the disease and can vary from 4 days to 2 weeks. It is not recommended to use more than 60 g. ointments for a period of one week. For inflammatory infiltration, psoriatic plaques on the elbows and knees, diseases of the joints and ENT organs, injuries, scars and ulcers, the drug is applied under an occlusive dressing. Change the dressing at least once a day to avoid side effect drug.
2. Ointment 5%. Pharmacological agent It is used only locally, it is unacceptable to take it internally. Place 1 cm of hydrocortisone ointment under the lower eyelid (conjunctival sac), then close your eyes and massage your eyelids to distribute the medicine over eyeball. Carry out the procedure 2-3 times a day, and the duration of the treatment course should not exceed 2 weeks. In some cases, the dosage and period of use of the product is varied by the attending physician, taking into account the overall picture of the disease.

Side effects

Sometimes there is hyperemia, swelling and itching in the areas of application.

Long-term use of the drug can provoke the development of secondary infectious skin lesions, as well as atrophic changes in the skin and hypertrichosis. In addition, prolonged use of the ointment in combination with an occlusive dressing on large areas of skin lesions can cause the development of symptoms characteristic of hypercortisolism, which is due to the manifestation of the resorptive activity of hydrocortisone.

Overdose

As a rule, an overdose of ointment occurs very rarely. When using hydrocortisone ointment for more than 10 days, the patient may develop the following disorders:

1. Disturbance in the functioning of the adrenal glands;
2. Allergic skin reactions;
3. Impaired visual function (when using hydrocortisone ophthalmic ointment);
4. Increased blood glucose levels;
5. Menstrual dysfunction in women;
6. Growth retardation (when using the drug in pediatric practice);
7. Poor wound healing due to addiction to the drug.

In addition, with prolonged use of hydrocortisone ointment, the patient may experience a persistent increase in blood pressure, the development of vasculitis, and disturbances in water-electrolyte metabolism.

Special instructions

If there is no expected effect during treatment with ointment already 1-2 days from the start of therapy, the patient should consult a doctor again in order to clarify the diagnosis and the adequacy of the prescribed therapy.

Drug interactions

The risk of developing cataracts increases when antipsychotics (neuroleptics), carbutamide and azathioprine are used against the background of corticosteroids.

Simultaneous use of GCS with anticholinergics (incl. antihistamines, tricyclic antidepressants) and nitrates increases intraocular pressure.