Diphtheria-tetanus toxoid purified adsorbed liquid (ADS-anatoxin). Diphtheria-tetanus toxoid purified adsorbed liquid (ADS-anatoxin) (Anatoxinum diphterico-tetanicum purificatum adsorptum fluidum)

ADS-M toxoid is administered to children and adults in order to develop immunity against diphtheria and tetanus in their bodies.

Indications for use

The suspension has been developed for:

1. Vaccination of persons who have not previously been vaccinated with ADS-anatoxin or its analogues. IN in this case we're talking about both adults and children over seven years of age
2. Carrying out routine revaccination of children aged 7-14 years (for vaccination of children from birth to 7 years, doctors use ADS-toxoid)
3. Vaccination of children who have had strong reactions to ADS toxoid.

In some cases, urgent vaccination with a drug containing diphtheria-tetanus toxoid is required. Such situations include:

• Out-of-hospital abortions
• Animal bites
• Frostbite and burns
• Gangrene or tissue necrosis of any type
• Injuries accompanied by violations of the integrity of the skin
• Childbirth outside of medical institutions.

Composition of the drug

One dose (0.5 ml) of the ADS-toxoid and ADS-M-toxoid vaccine used for vaccination contains:

• Flocculating diphtheria-tetanus toxoid
• Antitoxin-binding tetanus toxoid
• Merthiolate
• Aluminum hydroxide.

Immunobiological properties

Diphtheria-tetanus toxoid, introduced into the body, helps to develop immunity against diphtheria and tetanus. For the first vaccination of children, in most cases, ADS-toxoid is used, and for subsequent vaccinations, ADS-M-toxoid is used. These two vaccines differ from each other in the amount of toxoids they contain; the first has more, and the second has less.

Release forms

Cost from 130-250 rubles per package

The drug is presented in the form of a white or slightly yellowish suspension. During a long stay in one position, a clear liquid and loose sediment. ADS-M toxoid can be returned to its original state by shaking.

To package the ADS-M-anatoxin suspension, pharmaceutical companies use 0.5 ml or 1.0 ml ampoules, which are packaged in boxes of 10 pieces.

Directions for use

Diphtheria-tetanus toxoid is injected into large muscles. Only in case vaccinations for adults patients, the suspension can be injected subcutaneously into subscapular region. However, this vaccination option is unacceptable when administering ADS-anatoxin to children.

According to the instructions, 0.5 ml of the drug is required for vaccination. The ampoule with the suspension is opened immediately before administration to the patient, shaking thoroughly beforehand.

During pregnancy and breastfeeding

During pregnancy and lactation, it is not recommended to vaccinate with ADS-M-anatoxin or ADS-anatoxin. Women who have undergone revaccination can plan to conceive no earlier than after 30-35 days. If pregnancy is detected within 30 days from the date of vaccination, the woman must be under strict supervision of a gynecologist throughout the entire period of waiting for the child.

Contraindications

Administration of the suspension is contraindicated in patients with:

• Convulsive syndrome
• Hypersensitivity to the components of the drug
• Fever
• Infectious diseases
• Chronic diseases in the acute stage
• An allergic reaction to ADS-M toxoid or ADS toxoid, which was used in a previous vaccination.

Precautions

Despite the fact that ADS-M toxoid is one of the least reactogenic vaccines, those vaccinated are observed by a doctor for another 30 minutes after the procedure.

Cross-drug interactions

ADS-M toxoid, like ADS toxoid, can be administered simultaneously with drugs intended to develop immunity against polio. Such vaccines include Pentaxim, Imovax Polio and Poliorix.

Side effects

After vaccination with ADS-M toxoid, patients sometimes experience:

• The occurrence of allergies
• Temperature rise
• The occurrence of skin hyperemia
• Pain at the injection site
• The appearance of edema.

To quickly get rid of swelling, read the article:

Overdose

Cases of drug overdose by medical workers have not been described.

Conditions and shelf life

According to the instructions, diphtheria-tetanus toxoid, regardless of whether it is ADS-M toxoid or ADS toxoid, should be stored at a temperature of 4-8°C in a dark place. The vaccine should not be in a place accessible to children. The drug must be protected from freezing. Shelf life under proper conditions is 3 years.

Analogues

Imovax D.T. Adultery

Aventis Pasteur (France)
Price: 300 rubles – 1 dose (0.5 ml)

The drug is available as an injection suspension in multi-dose packages, syringes or ampoules. The suspension consists of diphtheria and tetanus toxoids, aluminum hydroxide, buffer solution and thiomersal.

Pros:

• A reduced dose of diphtheria toxoid in the vaccine, which minimizes the risk of developing an allergic reaction
• Convenient release form.

Cons:

• High cost
• Impossibility of use for vaccination of children.

ADSM-anatoxin contains the main thing active substance, which is called “diphtheria-tetanus toxoid.” The medicine is produced by JSC Biomed. The pharmacy is dispensed only for medical institutions. Medicine is administered to both children and adults so that their bodies develop immunity to diphtheria and tetanus.

Indications for use

The drug was developed to inoculate patients who have not previously been vaccinated with toxoid or its analogues. Adults and children over 7 years old are vaccinated. Vaccination is routine and is given to children from 7 to 14 years old. If it is necessary to vaccinate infants and children under 7 years of age, the drug Anatoxin is used.

Children who have an increased reaction to toxoid are also vaccinated with the medicine. Some patients require vaccination with a medicine that contains diphtheria-tetanus toxoid. Situations requiring vaccination with Anatoxin are as follows:

What is the composition of the drug?

One vaccine per 0.5 ml of ADS toxoid and ADS-M toxoid, which is used for vaccination, includes the following elements: diphtheria-tetanus toxoid and aluminum hydroxide, which binds tetanus toxoid.

Main properties of toxoid ADS-M

The name ADSM stands for, that the medicine is adsorbed, diphtheria-tetanus. When vaccinating people, it is used in small quantities. In the instructions for use of the drug it is designated “ADS-M”. Vaccination is done to protect the body of adults and children from tetanus and diphtheria. In medicine, there is another drug called DTP, which includes pertussis-free elements.

The last medication is suitable for the second vaccination. When a child is given ADS-M, this makes it possible to extend the duration of the immunity already present in the baby’s body. The medicine is found in children's body 2 times. The interval between vaccines is 4 weeks. If a patient has a complicated reaction to a vaccine, then children's pediatrician decides to increase the period between vaccinations. Revaccination is prescribed for the baby after 12 months. This is stated in the instructions.

Preparing for the vaccination procedure

2 days before vaccination you should treat the child's health with special care. You should not visit places where there is a possibility of contracting various infections. You should also avoid places with large crowds of people. If a child is given exotic foods, they will put a strain on the child’s immunity.

If an adult is vaccinated, drinking alcohol is strictly prohibited. If you adhere to the rules described above, the reaction to the vaccine will be favorable, and there will be practically no side effects.

Rules for using the medication

Before using the medicine children's pediatrician in mandatory examines the child. It is necessary to additionally make sure that the main active elements of the drug are not contraindicated for the baby.

Vaccination is carried out in 2 types. The first type of vaccine is in a syringe. It contains an individual dose for the patient. Ampoule vaccination is carried out several times. Instructions for use are independent of it. In one medical instrument Several vaccines cannot be mixed; this is prohibited according to the instructions. Before vaccination, the doctor must check whether the expiration dates have been met. The drug ADS-M should be stored only in the refrigerator. If it turns out that the medication is frozen, then it cannot be used.

How is vaccination done with ADSM?

The instructions for use of the drug say that the medication is injected into a large muscle. As a rule, the baby is vaccinated in the front of the thigh, under the shoulder blade or in the shoulder. The vaccine cannot be given in the buttock, because its fatty layer will make the vaccination ineffective.

What is necessary after vaccination

You should not leave the clinic immediately after the procedure.- this is what it says in the instructions for use. After vaccination, it is necessary to stay within the hospital walls for about half an hour. This is necessary so that if the body reacts sharply to the vaccine, the patient will need medical care. If after the vaccine they appear side effects or an allergic reaction, then doctors will be able to quickly eliminate negative manifestation medicines.

Along with the vaccine, doctors may prescribe an antihistamine. It is recommended to be used in conjunction with ADSM. An antihistamine is recommended as preparation for vaccination. It is also recommended by doctors to reduce the likelihood of consequences. The instructions for use say that compresses, lotions or ointments should not be applied to the area where the vaccine was given. After the procedure, you should not use warm compresses. Because this can lead to surgical intervention and abscesses.

What reactions are possible after using the vaccine?

If vaccination is given to a child under 7 years of age, then as a side effect an increase in temperature of up to 40 degrees Celsius may be observed. If a child has a fever, he needs to be given antipyretic tablets or a suspension. If vomiting occurs as a side effect after vaccination or headache, then as auxiliary tablets you need to take appropriate medications.

Reaction to medication administration

The medication is considered one of the least reactogenic drugs.

1. Some patients may develop the following side effects within 2 days after vaccination: malaise and elevated temperature.
2. Local side effects may also occur, which include swelling, hyperemia and pain.
3. Some patients experience allergic reactions after receiving the vaccine.
4. These include angioedema, polymorphic rash or urticaria.
5. Some children experience a mild allergic reaction after vaccination.

Due to the fact that an allergic reaction may occur after taking the drug, after medical procedure the patient must remain in the hospital for 30 minutes.

What are the contraindications for ADSM?

There are almost no contraindications to the use of the drug for both children and adults. The exception is pregnant women. During acute illness They will also not be vaccinated. If the patient is sick, then after recovery he is vaccinated, 5 days later.

If the child has light form disease, then it is allowed for vaccination when the clinical effects disappear.

If the patient is chronically ill, he is vaccinated after partial remission. If an allergic reaction is detected in a baby, he is vaccinated 5 weeks after the allergy ends. If a child has a stable manifestation of the disease, for example, skin rashes or latent bronchospasm, this is not considered a contraindication to vaccination.

Vaccination will be prescribed together with medications to eliminate the disease. On the day of vaccination the patient must be examined by a doctor. If a child's vaccination is delayed for any reason, he should be under the supervision of his attending physician. When the reasons why the patient was not vaccinated are excluded, he must be vaccinated.

Release form of the medicinal product

The medication is available in the form of a white or light yellow suspension. If the ampoule for a long time was in the same position, then the presence of a transparent precipitate is allowed. If ADSM is shaken, it will return to its original state. In pharmacies, the medicine is sold in ampoules of 1 or 0.5 mm. Cardboard packages are stacked in boxes of 10 pieces.

Is it possible to administer the drug when breastfeeding and pregnancy?

If a woman is pregnant or breastfeeding, then she is not recommended to be vaccinated with ADSM or ADSM toxoid. If a woman has been vaccinated with the drug, then she can plan a pregnancy a month later. If the vaccine was given during pregnancy, the pregnant woman should be under the strict supervision of the attending physician for all 9 months.

ADSM is one of the least reactogenic vaccines. But despite this, patients should be under the supervision of a doctor after vaccination within half an hour. If the medication is in a damaged ampoule or its labeling is incorrect, the medication should not be used. It is also necessary to carefully monitor the expiration date; if the drug has expired, it can no longer be used.

Cases of drug overdose by doctors have not been described. The medication must be stored at a temperature from + 4 to + 10 in a dark place. The medication should be located in a place inaccessible to children. ADSM should not be frozen. The shelf life of the vaccine when properly stored is 3 years. The drug has analogues: Zimovka and Avensis. The cost of one dose of the analogue is 300 rubles. for 0.5 ml. Analogs are available in the form of an injection suspension in ampoules or syringes. The drugs have the following advantages:

1. The vaccine contains a reduced dose of diphtheria toxoid.
2. This allows for minimal risk in the event of allergic reactions.
3. Medicines have convenient form release.

The disadvantages include their high cost and the inability to vaccinate children under 4 years of age.

The medication Diphtheria-tetanus toxoid, which was introduced into the child’s body, helps in developing immunity against diphtheria or tetanus. When a child is first vaccinated, the ADSM toxoid vaccine is used, and for subsequent vaccinations, ADS toxoid is used. These two medications are different. ADS toxoid contains large number toxoid, and ADSM toxoid contains twice as much.

Bottom line

The medication is injected into large muscles. If an adult is subject to vaccination, then the injection is given under the shoulder blade. But this option medical product is unacceptable when vaccinating a child. As stated in the instructions for use, the drug should be administered in an amount of 0.5 ml. The ampoule with the medication is opened immediately before administration to the child.

Before administering the drug, the ampoule must be shaken thoroughly. The medication should not be prescribed to a woman who is breastfeeding or pregnant. Pregnant women are strictly prohibited from getting vaccinated, but if it turns out that the vaccine was given and the woman did not know that she was pregnant, then she should be under strict medical supervision throughout the entire period of pregnancy.

The drug has contraindications which are as follows: elevated temperature, infectious diseases, convulsions, hypersensitivity to the main elements of the drug, allergic reaction, diseases in chronic form. After vaccination, the child must remain in a medical institution. This is necessary so that if the baby is found to have an allergic reaction to ADSM, then medical staff will be able to provide him with the necessary assistance in a timely manner.

The ADS-M vaccine is produced in the form of a suspension light color. The drug is packaged in disposable syringes or ampoules of 0.5 or 1 ml, that is, for 1 or 2 vaccination doses, 10 pieces per pack.

Pharmacological action

The drug provides the body with anti-diphtheria and tetanus resistance.

Pharmacodynamics and pharmacokinetics

It should be noted that the ADS-M vaccination means: in small doses. It is also a variation, but without the pertussis component.

This vaccine is used for revaccination in adult patients and children aged 4-6 years who previously received the DPT vaccine. Therefore, in this case, the ADSM vaccination does not so much build immunity as maintain the level of antibodies at the required level.

Also, this drug is intended for children with intolerance to the pertussis component, which is contained in DTP and ADS vaccinations, for the purpose of emergency immunization, for example, according to epidemic indications.

Indications for use

Vaccination with ADS-M for children over 6 years of age and adult patients is recommended as a prophylaxis against diphtheria and tetanus.

This vaccine is also indicated for adult patients over 18 years of age with:

• primary vaccination;
• carrying out systematic revaccination against diphtheria and tetanus. The vaccine contains a reduced dosage of diphtheria toxoid to reduce the risk of developing possible reactions hypersensitivity;
• the threat of tetanus due to injury.

Contraindications

The main contraindications for ADS-M vaccination:

• intolerance to its components;
• chronic diseases and their aggravation.

Caution in use is required when acute immunodeficiency when specialist advice is needed.

Side effects

For this drug characterized by low reactogenicity, but the likelihood of developing adverse reactions should not be excluded.

It has been established that the side effects of vaccinations in adults and children can be general or local. They usually appear within 1-2 days from the moment of administration.

Local reactions include: redness, induration, loss of sensitivity and swelling at the site where the vaccine is given.

Common side effects are: temperature increase , moodiness, lethargy, indigestion and indigestion.

The appearance of such symptoms after vaccination is considered normal and does not require treatment, although the use of or is acceptable. Experts also recommend drinking plenty of fluids.

Severe complications from the ADS-M vaccine are rare, but they can occur. , .

Vaccine ADS-M instructions for use (Method and dosage)

As the instructions on ADS-M vaccine, it is administered intramuscularly. A suitable place for its insertion in children is the anterolateral part of the thigh, under the shoulder blade or in the shoulder area.

Revaccination of children is performed at 14-16 years of age and its effect lasts for 10 years.

After 10 years it is held ADS-M vaccination in adult patients, which will help maintain immunity at the required level against tetanus and diphtheria. Then revaccinations are carried out at 10-year intervals. However, no upper age limit has been established.

Overdose

There are no known cases of vaccine overdose.

Interaction

There are no known drug interactions between this vaccine and other medications. But if during vaccination or revaccination the patient takes any medications, the doctor who conducts the examination before vaccination must be warned about this.

Special instructions

Intravenous injection into the buttock is unacceptable, as this can cause damage. sciatic nerve or blood vessels.

Carrying out immunosuppressive treatment or having an immunodeficiency can reduce the intensity of the immune response to the vaccine. Therefore, it is necessary to complete the therapy or ensure complete safety for the patient. Vaccinations can be given to people with chronic immunodeficiency when concomitant illness does not interfere with the formation of even a small level of antibodies.

Terms of sale

According to the recipe.

Storage conditions

A dark, dry and cool place with a temperature of plus 2-6°C is suitable for storing the vaccine. Freezing the drug is unacceptable.

Best before date

Analogues

Level 4 ATX code matches:

Exists imported vaccine Imovax D.T.Adult , which is better tolerated and does not lead to the development of adverse reactions.

There is also monovalent vaccines , that is, separately from diphtheria - AD and tetanus - AS.

Difference between DTP and ADS-M

Between DPT vaccinations and ADS-M there are great similarities. But DTP additionally contains a component that is directed against whooping cough.

However, for children under 4 years old, everything is completely different - it’s not just dangerous disease, but can also lead to death. This disease can develop at lightning speed. And if an adult may have a prolonged cough, then in children a spasm of the respiratory muscles may occur, leading to a sudden stop in breathing. Only immediate resuscitation measures will help save life.

Alcohol

When carrying out any vaccination, drinking alcohol is prohibited for 3 days before and after it. Then for a week it is recommended to limit the use of alcohol-containing products. If you do not follow this instruction, you may experience increased side effects and a decreased immune response.

ADS-anatoxin is a serum that provides prevention of particularly dangerous diseases: diphtheria and tetanus. When the active components enter the body, an immune response is formed that prevents pathogens from becoming active. ADS, also ADS-M toxoid, is prescribed to adults and children. Serums may have side effects. Toxoids are administered from the age of 3 months. If a child has had whooping cough, the doctor advises getting vaccinated against diphtheria and tetanus. Serum is used for repeated vaccinations. The drug ADS-M can be prescribed to children who have been shown to be hypersensitive to the vaccine.

Application of serum ADS-anatoxin

Before prescribing vaccination, the doctor analyzes what contraindications there may be. To do this, he studies the patient's medical history. The serum is administered intramuscularly. Active components should penetrate large muscles. ADS-toxoid is injected into the buttock; when re-vaccinating an adult, it is injected into the area of ​​the scapula. Before using the drug, the doctor shakes the bottle and then carefully opens it.

ADS-anatoxin liquid has a light suspension. A single dosage is 0.5 ml. The interval between administrations is 1 month. To ensure the prevention of particularly dangerous diseases, ADS-toxoid must be administered twice. Some patients are prohibited from receiving repeated vaccinations. This is due to contraindications. 9 months after the vaccination course, you will need to re-vaccinate using ADS-M serum. You cannot shorten the intervals.

Side symptoms

If the patient uses toxoid serum, he may experience side effects. The most common:

• weakness;
• swelling of the skin;
• infiltrate in the injection area.

In exceptional situations appear neurological disorders. Rare consequences include seizures and encephalitis. The baby may experience continuous crying. Sometimes toxoid causes allergies. In this case, a polymorphic rash or urticaria occurs. Using the drug can lead to anaphylactic shock, but this is extremely rare.

Before using ADS-toxoid serum, you need to identify all contraindications. It is important to comply with storage conditions. The patient should be under medical supervision for half an hour after administration. If severe allergies occur, the patient is resuscitated. If side effects occur, treatment is necessary.

Contraindications for use

The instructions for ADSM toxoid contain information about all contraindications. The serum is not recommended for patients who are hypersensitive to its components, in particular toxoid, including staphylococcal. If you are allergic to diphtheria drugs or anti-tetanus toxoid drugs, such as Bubo-M, your doctor does not recommend administering this serum. Other contraindications:

• oncological pathologies;
• epilepsy accompanied by seizures;
• undergoing radiation therapy;
• taking certain medications.

Serum is not prescribed if chronic diseases are aggravated. Contraindications are viral and infectious pathologies. If chronic diseases worsen, you need to wait for remission, only then use the drug. ADS toxoid is contraindicated in patients with long-term pathologies. It is not recommended to use the medicine for tuberculosis, meningitis, viral hepatitis.

It doesn't fit with others by similar means. There is no data on overdose. ADS toxoid is stored in a dry room at a temperature from + 5 to plus 20 degrees. Do not hold the drug under straight sun rays, as well as in rooms with high humidity. If the packaging was damaged during storage, the doctor disposes of it. The suspension is used immediately after opening, the medicine is open form not intended for storage.

Similar serum "Ad-M-Biolek"

This is an immunobiological suspension that is used to prevent diphtheria. Active ingredient « Diphtheria toxoid"Participates in the formation of immunity against diphtheria. The toxoid contained in Ad-M-Biolek is in sorbed form. Auxiliary components - gel, sodium chloride, water for injection. The maximum single dosage is 5 ml. Ad-M-Biolek is used for vaccination of adults and children. The serum is recommended for people who have suffered from diphtheria.

If you have been vaccinated with Ad-M-Biolek serum, you should wait several years, after which you should repeat the procedure. Thus, the body will retain defensive reaction. The drug is not prescribed to patients who are allergic to toxoid or other serum components. Ad-M-Biolek is prohibited from use by those who have developed anaphylactic shock for drugs containing toxoid. Other contraindications:

• pathologies accompanied by encephalopathy;
• protracted neurological diseases, including epilepsy,
• immunodeficiency state;
• any aggravated pathologies.
• intestinal diseases;
• illnesses characterized by fever.

Side symptoms

If the body exhibits hypersensitivity to components of the ADS-toxoid serum, side effects may occur.

1. Children experience increased fatigue.
2. A headache may occur.
3. Body temperature rises to 38 degrees.
4. Some patients experience swelling and redness of the skin.
5. Nausea occurs.
6. Possible enlarged lymph nodes.

If side effects appear after administration of the drug, you should immediately consult a doctor. He will adjust the treatment regimen. The shelf life of the medicine is 3 years from the date of manufacture. Ad-M-Biolek is stored in a dry place with moderate humidity.

Adasel

This is another analogue of ADS toxoid. It is a combined adsorbed immunobiological drug that is used for the prevention of diphtheria, tetanus and whooping cough. Adasel contains diphtheria and tetanus toxoids, they are combined with pertussis components. The preparation contains small quantity antigen. Adacel is used for the prevention of infectious viral diseases Excipients: phosphates, formaldehyde, water for injection.

The maximum single dosage is 5 ml. The drug is prescribed to children who have reached the age of 4 years. Adacel is not recommended for elderly patients over 63 years of age. If the patient has had diphtheria or whooping cough, repeated vaccination is recommended because the body does not always produce a strong immune response. Children are re-vaccinated after 10 years. Contraindications are neurological diseases, including epilepsy. If they escalate chronic pathologies, you need to wait for regression.

The serum is not recommended for pregnant and nursing mothers. It is injected intramuscularly into the shoulder. It must not be allowed to active substances Adacel entered the blood vessels. Overdose on at the moment not recorded. Side effects:

• weakness, malaise;
• increased fatigue;
• headaches;
• skin rash;
• temperature rise.

If side effects occur, you should consult a doctor. He will adjust the vaccination schedule. The drug is stored in a dry place, out of reach of children, at an optimal temperature of + 15 degrees. Shelf life: 3 years.

Application of Trianatoxin

Patients are often interested in what the Trianatoxin vaccine is for. The suspension is administered to ensure the prevention of botulism. The drug Trinatoxin is recommended for patients over 16 years of age. However, if there is a pronounced reaction to its components, you should stop using it. The suspension has a number of contraindications.

1. It is not administered during infectious pathologies.
2. Trinatoxin is prohibited for patients diagnosed with central nervous system diseases.
3. Contraindications are pathologies that are in the acute stage.
4. The serum is prohibited for those who have a disease of the circulatory system.
5. Anti-botulism medication is not prescribed if diagnosed bronchial asthma, allergic pathologies.
6. Contraindication is an oncological process.
7. It is prohibited to use the serum during pregnancy and breastfeeding.

If there are no contraindications, the serum is administered 2 times. The interval is 30 days. Repeated vaccination carried out after 7 months. Revaccinations are carried out every 5 years. The dosage of the drug is 1 ml. Trinatoxin is intended for subcutaneous administration. You must shake it before using it. If the packaging is damaged, you should stop using the serum. Immunity after administration lasts for 5 years. The drug may cause side symptoms:

• malaise;
• lack of coordination;
• swelling of the skin;
• the appearance of infiltration.

In exceptional situations, anaphylactic shock occurs. Important to consider special instructions to the drug. If there is no appropriate marking on it, you should refuse to use it. You cannot use whey that contains dense flakes. The doctor opens the ampoules, observing the rules of antiseptics. If the ampoules are opened, the drug becomes unsuitable for storage. The patient should be under the supervision of a doctor for half an hour, as there is a possibility of severe side symptoms. If necessary, antishock medications are used. Vaccination against particularly dangerous diseases is not mandatory, however, it is recommended to increase the body’s immune response.

Diphtheria-tetanus toxoid

Composition and release form of the drug

1 ml (2 doses) - ampoules (10) - cardboard packs.

Pharmacological action

Indications

- prevention of diphtheria and tetanus in children from 6 years of age, adolescents and adults.

Contraindications

- hypersensitivity;

- pregnancy.

Dosage

IM into the upper outer quadrant of the buttock or the anterior outer part of the thigh or deep subcutaneously (adolescents and adults) into the subscapular area in a single dose of 0.5 ml.

Before administration, the drug must be shaken thoroughly until a homogeneous suspension is obtained.

For planned age-related revaccinations at 7 and 14 years of age, then every subsequent 10 years without age limitation - once.

For vaccination children 6 years and older, previously unvaccinated against diphtheria and - the vaccination course consists of two vaccinations with an interval of 30-45 days. Reducing the interval is not allowed. If it is necessary to increase the interval, the next vaccination should be carried out as soon as possible. The first revaccination is carried out 6-9 months after the completed vaccination once, the second revaccination is carried out at an interval of 5 years. Subsequent revaccinations are carried out every 10 years without age restrictions.

As a replacement for diphtheria-tetanus-pertussis vaccine (DPT vaccine) or diphtheria-tetanus toxoid with standard concentration of antigens (ADT toxoid) in children with strong general reactions (hyperthermia up to 40°C and above) or post-vaccination complications to these drugs. If the reaction develops to the first DPT vaccination(ADS), then ADS-M toxoid is administered once no earlier than after 3 months; if a reaction develops to the second vaccination, then the course of vaccination against diphtheria and tetanus is considered completed. In both cases, the first revaccination with ADS-M toxoid is carried out after 9-12 months. If a reaction has developed to the third DPT vaccination (ADS), the first revaccination with ADS-M toxoid is carried out after 12-18 months.

To carry out a course of vaccination adults, who have not previously been reliably vaccinated against diphtheria and tetanus are full course immunization (two vaccinations with ADS-M toxoid with an interval of 30 days and revaccination after 6-9 months).

IN foci of diphtheria preventive vaccinations carried out in accordance with the instructions and methodological documents of the Russian Ministry of Health.

Side effects

Rarely(in the first two days): hyperthermia, malaise, local reactions(pain, hyperemia, swelling); in isolated cases– angioedema, urticaria, polymorphic rash, minor exacerbation of allergic diseases.

Special instructions

Persons who have had acute illnesses are vaccinated 2-4 weeks after recovery. In mild forms of the disease, vaccinations are allowed after the clinical symptoms disappear.

sick chronic diseases vaccinated upon achieving complete or partial remission. Children with neurological disorders are vaccinated after progression of the process has been ruled out. Sick allergic diseases vaccinations are carried out 2-4 weeks after the end of the exacerbation, while stable manifestations of the disease (localized skin phenomena, hidden bronchospasm) are not contraindications to vaccination, which can be carried out against the background of appropriate therapy.

Immunodeficiencies, HIV infection, and supporting course therapy(including GCS) are not contraindications to vaccination.

In order to identify contraindications, on the day of vaccination, the doctor conducts a survey of parents and examines the vaccinated with mandatory thermometry. When vaccinating adults, preliminary selection of persons to be vaccinated is allowed, with their questioning medical worker on the day of vaccination, those administering the vaccination. Persons temporarily exempt from vaccination must be monitored and registered and vaccinated in a timely manner.

If epidemiologically necessary, ADS-M toxoid can be administered against the background of an acute illness. In case strong reaction Not previous dose of this drug, a repeated dose is administered against the background of the use of GCS (orally - 1-1.5 mg/kg/day the day before and immediately after vaccination).

Persons vaccinated with tetanus toxoid are vaccinated with diphtheria toxoid between revaccinations.

ADS-M toxoid can be administered a month later or simultaneously with polio vaccine and other vaccines national calendar vaccinations.

Considering the possibility of developing allergic reactions immediate type in particularly sensitive persons, vaccinated persons must be provided with medical supervision for 30 minutes. Vaccination sites must be provided with anti-shock therapy.

Persons who gave for introduction ADS-M toxoid severe forms allergic reactions, routine vaccinations the drug is stopped.

Not suitable for use in ampoules with damaged integrity, lack of markings, if changed physical properties(discoloration, presence of unbreakable flakes), improper storage.

The opening of ampoules and the vaccination procedure are carried out in strict compliance with the rules of asepsis and antiseptics. The drug cannot be stored in an opened ampoule.

The administration of the drug is registered in the established accounting forms, indicating the batch number, expiration date, manufacturer, and date of administration.

Pregnancy and lactation

Use in childhood

Application is possible according to the dosage regimen.

Children with neurological disorders are vaccinated after progression of the process has been ruled out.