Cough

Antiviral drugs rimantadine for children. Possible contraindications and side effects

Unfortunately, viral diseases can hardly be considered rare. Particularly susceptible to various infectious diseases Small children. What to do in such situations? What drugs can be used? Quite a popular remedy in modern medicine considered "Remantadine" for children. But what does it contain? How to take it correctly? Are there any contraindications and side effects? The answers to these questions interest many parents.

Composition and release form of the drug

It is immediately worth noting that the drug "Remantadine" for children is produced in two forms - syrup and tablets. Choice in in this case depends on the age and condition of the child and, possibly, personal preferences.

The main active substance is rimantadine hydrochloride. Each tablet contains 50 mg of this component. As for excipients, lactose monohydrate, povidone, anhydrous colloidal silicon dioxide, as well as corn starch and magnesium stearate are also used in production.

The syrup is a thick, sweet liquid that is reddish or pink in color. The medicine is sold in 100 ml dark glass bottles. The active substance, of course, is the same rimantadine hydrochloride. One teaspoon (5 ml of syrup) contains 10 mg of this component. In addition, the syrup contains sugar, purified water, sodium alginate and dye.

Basic pharmacological properties

Today, many parents prefer to use Remantadine tablets, syrup for children. Reviews indicate that the drug is really effective. It is immediately worth noting that this is a synthetic product, the active components of which are adamantane derivatives. The medicine blocks the transition of viral genetic material into the cell cytoplasm. For more late stages diseases, the drug interrupts the process of transcription of the viral genome and prevents the release of new viral particles from cells. Given medicine active against many strains of influenza virus, especially influenza A.

After oral administration, the drug is quickly absorbed by the intestinal walls and enters the blood, where it binds to plasma proteins. In the liver, the active substances are deactivated, turning into metabolites, which are then excreted by the kidneys.

Taking the medicine provides relatively quick effect- flu symptoms become less pronounced, the degree of serotological reactions decreases, and the process of recovery and restoration of the body is significantly accelerated.

Indications for use

In what cases do pediatricians prescribe the drug "Remantadine"? For children this medicine is a fairly effective antiviral agent, so it is used to treat diseases viral origin, including ARVI, influenza, etc. According to research, this drug relieves the symptoms of the disease and speeds up the child’s recovery process.

There is another purpose for using the drug Remantadine. Syrup for children is also effective as a prophylactic agent. For example, a child can take the drug even before the onset of a flu or cold epidemic - in such cases, the risk of developing the disease is much lower, even if the child is constantly in a group. Remantadine is also used for prevention tick-borne encephalitis— the drug also copes well with this task.

Syrup "Remantadine" for children: instructions

It’s worth noting right away that if you have symptoms, you should consult a doctor - under the guise of a cold, more often than not is hidden. serious illness, so an examination by a specialist is still necessary. The treating pediatrician, of course, will select the form of the drug that is suitable for the child, as well as the most effective dosage.

This medicine is not used to treat children in the first year of life, which is due to the imperfect functioning of the baby’s kidneys - there is a possibility of accumulation of dangerous metabolites in the body. What does the dosage regimen look like for children 1-3 years old? On the first day you need to take 20 ml of syrup three times. On the second and third days, the daily dose is 40 ml, divided into two doses. On days 4-5 you need to drink 20 ml of syrup at a time.

The dosage of the drug "Remantadine" for children 3 years and older looks a little different. On the first day, the syrup should be taken three times, 30 ml each. On days 2-3 the daily amount is reduced to 60 ml (divided into two doses), and on days 4-5 a single dose of 30 ml is needed.

How to take Remantadine tablets for children?

As a rule, children from 7 to 14 years old take Remantadine tablets. The dosage for children is determined by the doctor; below are only general recommendations.

Children 7-11 years of age should take one tablet twice daily. Older children (11-14 years old) need to take one tablet three times a day. The course of treatment usually lasts about five days.

If we're talking about about prevention, children are prescribed to take one tablet a day for two weeks.

Are there any contraindications?

Today, many doctors prescribe the drug "Remantadine" for children. But are there any contraindications to taking it? In fact, not all categories of patients can use this remedy. In particular, the medicine is contraindicated in children with acute or chronic kidney and liver diseases. Contraindications also include some disorders from thyroid gland, including thyrotoxicosis. And, of course, the drug should not be taken by children with hypersensitivity to any of its components.

What side effects can the drug cause?

Are there any risks if specialists prescribe the drug "Remantadine" for children? Reviews from parents and doctors indicate that the medicine is most often well tolerated by the body, without causing any complications. However, the appearance adverse reactions it's still possible.

Sometimes patients experience allergic reactions, which are accompanied by redness, skin rashes, itching, urticaria, slight swelling. Disturbances from the digestive system are also possible. Some children complain of dry mouth, flatulence, and pain in the stomach. Sometimes nausea, vomiting and diarrhea occur.

What else is Remantadine dangerous for children? In a number of cases, effects of the drug on the nervous system were noted. For example, side effects include headaches and dizziness, increased excitability, constant nervousness, sleep problems, anxiety, impaired concentration, etc.

If any disturbances occur, you should stop taking the medication for a while and consult a doctor.

Are there any good analogues?

Today, many people are interested in questions about whether it is possible to replace the drug Remantadine with something. Only the attending physician has the right to select analogues for children, since everything here depends on the age of the child, his state of health, etc. Nevertheless, there are some medicines that have the same properties.

What to do if you couldn’t get Remantadine syrup for children at the pharmacy? "Orvirem" is another drug that will provide your baby with the same result. Moreover, this medication has the same active substance- rimantadine hydrochloride.

There are others, no less effective medicines. For example, Remavir is a fairly good antiviral drug, which helps to cope with the flu in early stage. And for the children younger age(from 1 to 7 years) the drug “Algirem” is suitable, which also has antiviral properties.

The drug "Remantadine" for children: reviews from doctors and patients

Of course, when choosing the right medicine for a child, you need to pay attention to many facts. So what do doctors and patients say about the drug Remantadine for children? Reviews confirm that this remedy really copes with its task perfectly - the disease is much easier, and the recovery process goes faster. Moreover, correct use of Remantadine helps protect against colds even during an epidemic.

According to statistics, side effects occur rarely and, as a rule, are associated either with the presence of contraindications or with improper use of the drug. The drug "Remantadine" has another undoubted advantage - it is a relatively low price. But do not forget that before starting to take any drug you need to consult a doctor.

Antiviral .

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Remantadine, what are these pills for? This antiviral agent, the main mechanism of which is inhibition of the early stage of virus reproduction after its penetration into the cell, blocks the transfer of the genetic material of the virus into the cell cytoplasm.

Affects the virus influenza A and the virus tick-borne encephalitis (arbovirus). It is effective when taken at the initial stage of infection (6-7 hours), which reduces the incidence of influenza and the severity of symptoms.

Pharmacokinetics

Slowly but completely absorbed into the gastrointestinal tract. 40% binds to blood proteins. The concentration of the active substance in nasal secretions is 50% higher than the plasma concentration. Metabolism occurs in the liver. The half-life is 24-30 hours. It is excreted by the kidneys. In patients with renal failure accumulates in toxic concentrations in the absence of dose adjustment.

Indications for use of Remantadine

treatment flu in the early stages;
prevention of influenza during epidemics;
prevention caused by ticks.

Contraindications

kidney diseases;
liver diseases;
age up to 7 years;
pregnancy;

Prescribed with caution when arterial hypertension , . Elderly people with high blood pressure have an increased risk hemorrhagic stroke . With a history of epilepsy, the development of an epileptic seizure is possible.

Side effects

pain in the stomach area, anorexia , bloating, dry mouth, nausea;
headache, nervousness, insomnia, anxiety, decreased concentration, excitability, drowsiness;
allergic reactions.

Instructions for use of Remantadine (Method and dosage)

Remantadine tablets, instructions for use

The tablets are taken orally after meals. For the treatment of influenza, take according to the following scheme: 1st day - 100 mg three times, on the 2nd and 3rd days - 100 mg twice, 100 mg on the 4th day. For the purpose of prevention - 50 mg per day for 10 to 15 days.

How to take the drug if you are bitten by a tick? During the first 72 hours, take 100 mg 2 times a day.

Instructions for use Remantadine STI

For the treatment of influenza, take according to the following scheme: 1st day - 100 mg three times, on the 2nd and 3rd days - 100 mg twice, on the 4th day - 100 mg 1 time. For the purpose of prevention - 50 mg per day for 10 to 15 days. Remantadine Actitab has the same indications and is used in the same dosage regimen.

Children from 1 year of age are prescribed Remantadine in syrup. Syrup for children is produced under the name Orvirem And Algirem . The dosage method will be indicated below.

Overdose

An overdose is manifested by nausea, the appearance of a metallic taste in the mouth, and the urge to vomit. A psychedelic trip is typical, accompanied by fear, panic, delirium, hallucinations, intense thought process. Appointed intravenous administration 1-2 mg (adults) and 0.5 mg for children.

Interaction

Adsorbents And enveloping drugs reduce the absorption of the active substance.

Agents that acidify urine reduce the effectiveness of rimantadine, while agents that alkalize urine increase the effectiveness. The clearance of rimantadine decreases when taken.

Rimantadine reduces the effect of antiepileptic drugs.

Reduces the maximum concentration of the active substance in the blood simultaneous administration And acetylsalicylic acid .

Terms of sale

Over the counter.

Storage conditions

Storage temperature up to 25 °C.

Best before date

Remantadine for children

Instructions for rimantadine for children: children 7-10 years old are prescribed tablets - 50 mg twice, from 10 years old - 50 mg three times a day. In severe cases, it can be given to children 3–7 years old, but at a dose of 1.5 mg/kg/in 2 divided doses.

Syrup Algirem (rimantadine + matrix carrier alginate ) can be used for children from 1 year. has an adsorbent and detoxification effect, which enhances the antitoxic activity of the drug. Reduce its dosage and reduce the risk adverse reactions allows more long time circulation of Algirem in the blood. A teaspoon of syrup contains 10 mg of rimantadine, take it after meals, according to the scheme.

From 1 to 3 years: 2 tsp. syrup three times a day on day 1; 2 tsp each twice a day on days 2 and 3; Day 4 – 2 tsp. syrup 1 time.

From 3 to 7 years: 3 tsp. three times a day on day 1, 3 tsp. twice a day on days 2 and 3; Day 4 – 3 tsp. 1 time.
Effective when taken in the first two days from the onset of the disease. Combines well with (ointment, gel, rectal suppositories).

Antiviral drugs of other groups: can be prescribed to children over one year old - 2 mg/kg 2 times, and approved for use in children over 3 years of age.

Analogues

Level 4 ATX code matches:

Analogues having one active substance and similar antiviral effect: Remantadine Sti , Olvirem , Remantidine Actitab , Polyrem , Algirem , Arbidol , , Tamiflu .

Reviews about Remantadine

Remantadine tablets, what are they taken for? This is what suppresses the replication of the virus. It is a “long-liver” in the antiviral drug market - it has been used since 1975. Its preventive use is effective during influenza epidemics in closed groups, as reported in many reviews. However, in last years Most influenza A viruses (up to 50%) have acquired resistance to this drug, so it has lost its relevance. It is not effective against other respiratory viral diseases and the A/H1N1 virus, which causes pandemics, is resistant to it. In this connection, the Ministry of Health and Social Development of the Russian Federation does not recommend the use of rimantadine during the pandemic period.

The sensitivity of viruses to class II drugs remains: zanamivir, peramivir. Class III drugs (, camostat) have appeared recently and occupy a leading position in the treatment of influenza.

Infectious diseases predominate among other diseases. Antibiotics are used to treat viral infections when cold symptoms appear. Let's try to figure out what indications for treatment the drug Remantadine has - instructions for use; components that ensure the effectiveness of the drug; What are the possible reactions to the medication?

Antiviral Remantadine

IN medical practice The antiviral activity of the drug is used. According to instructions:

The drug is used to treat influenza A, the drug is used as prophylactic.
In case of influenza B, the drug has an antitoxic effect.
Remantadine cures viral encephalitis. Ticks are carriers of the disease in spring and summer.
Antiviral drug used for herpes infection.
The medication helps improve immunity by increasing the activity of lymphocytes and the production of alpha and gamma interferons.

Compound

The chemotherapy drug Remantadine is a derivative of adamantane. It was first synthesized from ketoxime. Antiviral effect The drug provides the active component - rimantadine hydrochloride. In relation to the influenza virus, it is more effective than adamantane and is less toxic to the body. The active element is a white crystalline powder that dissolves well in alcohol and poorly in water. Compound auxiliary elements medications depend on the form of release.

Release form

The synthetic antiviral agent is produced by the domestic pharmaceutical industry. Remantadine is available in:

tablets 50 mg;
capsules 100 mg.

Remantadine tablets white, flat, chamfered, placed in plastic ten-cell contours. One cardboard package contains two such packaging and instructions for use. In addition to rimantadine, the composition of the tablets includes Excipients:

potato starch;
magnesium stearate;
microcrystalline cellulose;
lactose monohydrate.

White gelatin capsules contain powder orange color(deviations from pink to brown shades are allowed). In addition to rimantadine, the capsule contains additional components:

gelatin shell;
lactose monohydrate;
potato starch;
stearic acid;
dye.

Pharmacodynamics and pharmacokinetics

Antiviral therapy Remantadine is based on a mechanism by which viral reproduction is disrupted at an early stage. It is effective to treat viral diseases with the drug immediately after a tick bite and when the first signs of influenza or herpes appear. Viral cells are blocked by the active component from the moment they enter the body until the start of replication (reproduction).

The active substance changes the level of acidity inside the shell (vacuole) that surrounds the viral particle after it enters the cell. The changed environment prevents the fusion of the viral particle with the vacuole membrane. After these processes, penetration of the virus into the cell cytoplasm and exit from it becomes impossible. Under the influence of Remantadine, rupture of the protective shell and further reproduction of the virus are prevented.

It is believed that the influenza A M2 gene, which is responsible for the synthesis of the viral protein, is susceptible to the active component. After changing the gene structure, the influenza virus becomes resistant (resistant) to the drug. Remantadine is completely but slowly absorbed from the intestine and metabolized by the liver. After absorption, a 50% greater concentration of the substance in nasal secretions is observed compared to plasma.

Excretion by the kidneys in adults occurs after 72 hours. The substance is eliminated more slowly in persons suffering from renal failure and with increasing age of the patient. For such patients, the risk of accumulation increases active component in the body in toxic concentrations, therefore elderly patients and people with chronic illnesses should reduce the dose of rimantadine.

Remantadine - indications for use

The instructions attached to the drug contain a list of instructions when it is advisable to take the medicine. Indications for use are:

Treatment of influenza caused by strains of virus A susceptible to the substance. The most effective remedy occurs when the first flu symptoms appear, within 48 hours. Exist positive reviews about the use of the medicine. In patients with influenza, after consuming the drug, an antitoxic effect is observed - a decrease in headache, muscle and joint pain, temperature, and recovery is accelerated.
Flu prevention. Rimantadine reduces the risk of infection during influenza epidemics or during contact with infected patients. For prophylaxis, rimantadine is recommended to be taken for two weeks to achieve an antiviral effect. The duration of action of the drug is 6 weeks.
Tick-borne encephalitis, prevention. After a tick bite, you do not need to wait for symptoms of the disease; you must take the drug immediately. As a preventive measure, it is recommended to use the medicine before going into the forest.

Contraindications

It is unacceptable to self-medicate. According to the instructions, it is not recommended to use the medicine if you have:

chronic kidney disease;
thyrotoxicosis;
chronic liver disease;
individual sensitivity to components.

The medication is contraindicated during pregnancy and childhood up to 7 years. The doctor makes the appointment and takes into account the following:

May worsen when taking medications chronic diseases.
Patients with epilepsy should take the drug with caution. He needs to be under the supervision of a doctor. Taking medication while taking antiepileptic drugs may cause epileptic seizure.
May come arterial hypertension in patients with cerebral atherosclerosis.

Directions for use and dosage

How to take Remantadine for patients is determined by the doctor. The regimen, scheme and duration of treatment are influenced by the patient’s age, his individual characteristics, presence of other diseases. The medicine is taken orally after meals and washed down with water. The instructions contain recommendations for taking:

For the treatment of influenza: 300 mg on the first day of illness (in one or three doses); 2 times 100 mg on days 2-3; 100 mg on days 4-5;
For prophylactic intake if there is a flu epidemic or there has been contact with a patient: 50 mg daily for two weeks.
For the prevention of encephalitis: immediately after a tick bite for 3 days, 200 mg/day in two doses.

Remantadine for children

Remantadine tablets are prescribed to a child after reaching 7 years of age, and capsules after 14 years of age. Remantadine is recommended for children for treatment and prevention. After a child falls ill with the flu, for children under 10 years of age the doctor prescribes 50 mg 2 times a day in the first 72 hours of illness. For a child over 10 years of age, the dose is 150 mg (in three doses) in the first three days after infection with influenza.

Drug interactions

During treatment with the drug, you should not drink alcohol, because disorders may occur. nervous system. Exist chemical compounds, capable of enhancing or suppressing each other's action. When choosing a course of treatment, the doctor takes into account:

During the period when antiepileptic drugs and Remantadine are taken simultaneously, there is a risk that anticonvulsant therapy will not be effective. Active ingredient suppresses its action.
Paracetamol and acetylsalicylic acid reduces the effectiveness of the drug due to an increase in the rate of excretion of the active substance in an acidic environment.
Sodium bicarbonate reduces the excretion of the element by the kidneys and increases the strength of its action.
Absorbents reduce the absorption and effectiveness of Remantadine.

Side effects and overdose

The instructions contain a warning about the possibility of overdose of the drug. There are reviews from patients about the body’s reaction to taking the medicine. When found side effect you must stop using the medicine and consult a doctor. After taking the drug you may experience:

drowsiness, dizziness, headache, insomnia, loss of concentration, dry mouth;
flatulence, diarrhea, loss of appetite, nausea, vomiting;
itching, rash, urticaria;
hyperbilirubinemia.

Remantadine has a medicinal effect on influenza viruses of groups A, B and A2. It is prescribed both for the treatment of viral influenza infection and for its prevention. This is especially important in the midst of epidemics, as well as for patients who have lung and heart diseases.

The drug has serious contraindications, it not recommended for use on newborns.

Description of the drug and its pharmacological action

Remantadine is a synthetic drug.

By chemical structure is a derivative of adamantane.

Remantadine inhibits the intracellular development of viruses.

It is active against influenza and encephalitis pathogens. The action of the drug inhibits the spread of viruses to other cells of the body. The acidity of the environment inside the cell, due to the action of the drug, becomes weaker. This prevents viruses from multiplying and penetrating into the cell cytoplasm. The effect of inhibiting viruses by the drug in the initial stage of the disease works well.

The medicine effectively reduces viral toxicosis. In addition, it stimulates the production of gamma and alpha interferons, which activate the body's defenses.

The drug is absorbed into the blood as it moves through gastrointestinal tract. As part of the blood, it enters directly into tissue cells.

Drug degradation in the liver and withdrawal it with urine happens in about a day. Part of the composition of the drug is excreted unchanged by the kidneys, a certain proportion comes out as products of intracellular metabolism.

If kidney function is impaired, toxic accumulation of the drug in the body in dangerous quantities is possible.

Release form of the medicine

Remantadine is available in tablets of 0.05 g. in packs of 10 and 20 pieces.

There are syrups similar action, which contain Remantadine. In particular, it is the main component in medicinal syrup Orvirem. This syrup is available in dark-colored bottles with a capacity of 100 ml.

Indications for use and dosage

The medicine is used to treat influenza infection and tick-borne encephalitis in initial stages, as well as for prophylactic use in the presence of an influenza epidemic.

For children over 7 years of age, during prophylaxis, 1 tablet is prescribed once a day for 2 weeks.

For effective treatment Remantadine should be started in the first hours of the disease.. If you start taking medicine for an illness that lasts longer than 18 hours, the treatment will not be as active. However, the infection will not be as severe.

The medicine in tablet form is approved for children over 7 years of age.

For therapeutic effect the drug should be given 1 tablet 2 times a day to children from 7 to 10 years old.

For children aged 11-14 years daily dose can be increased and treated by giving the child one tablet three times a day.

Treatment is continued for up to five days.

In the form of syrup Remandatin can be prescribed children over one year of age. From 12 months to the age of three, children are treated according to a certain regimen, starting with 2 teaspoons 3 times a day and ending with two teaspoons once a day.

Children from three to seven years of age are given the medicine in syrup, 3 teaspoons three times a day at the beginning of treatment, then the dose is reduced to 3 teaspoons once a day.

For children from birth to one year of age Remantadine contraindicated in any dosage form!

Side effects and contraindications

Among the main contraindications are:

Children under 7 years of age (medicine in tablet form).
Epilepsy.
Increased thyroid function.
Cerebral atherosclerosis.
Various forms of acute and chronic kidney and liver diseases.

Regardless of the form of release of the medicine should not be given to children with individual intolerance!

In case of hyperthyroidism, the medicine can provoke in the patient excessive irritability, tremors of limbs, sleep disturbances. In epilepsy and other forms of convulsive readiness, Remantadine contributes to the aggravation of these phenomena.

Some patients react to the drug with abdominal pain, nausea, vomiting, reluctance to eat, various negative manifestations from the gastrointestinal tract.

Undesirable side reactions may also include:

Phenomena of dizziness.
Pain in the head.
Lethargy and weakness.
Noise in ears.
The patient feels sleepy.
Depressive state.
Weakening of attention.
Swelling in the throat and, as a result, a hoarse voice.
Allergic reactions in the form of itching and other manifestations.

In all of the above cases, you must immediately stop giving your child Remantadine!

Considered quite good for children effective drug, which is used in the treatment of viral colds. This product is available both in tablets and in sweet syrups.

Children's "Remantadine": description and properties of the medicine. As already mentioned, this drug has antiviral properties. It is quite quickly absorbed by the intestinal wall, from where it enters the bloodstream and spreads throughout the tissues and organs. Processed in liver tissues. Metabolites of the drug are excreted mainly by the kidneys.

It is recommended to take the medicine "Remantadine" for children in the first hours and days of the disease - it is during this period that it is most effective. Penetrating into cells, it increases the acidity of the cytoplasm, which in turn prevents the viral particle from penetrating the genetic material. But the medicine also affects already infected cells, as it makes it impossible for the virus to enter the blood and lymph and spread to neighboring cells. cellular structures and fabrics.

The drug "Remantadine" for children: when should it be taken? Most often, this drug is prescribed as a preventive measure, especially during the period of spread and growth of the epidemic. viral diseases. Correct technique protects the child’s body from infection and neutralizes viral infection. This is very important for those children who are in a group (kindergartens, schools, clubs, etc.), since the risk of getting sick is minimized.

On the other hand, the drug "Remantadine" is also used as part of complex treatment. It is very important to start taking it no later than 18 hours from the onset of the first symptoms. Of course, medicine does not guarantee a quick cure for the disease. But it has been proven that in children taking the drug, the disease is milder and recovery occurs faster.

This medicine is used to treat and prevent influenza and tick-borne encephalitis.

The drug "Remantadine" for use

This drug, released in tablet form, is approved for use by children over seven years of age. Syrups can be used for children over one year of age.

Your pediatrician will tell you about the dosage and regimen. As a rule, it is recommended to take one tablet 2-3 times a day. The syrup should be given two teaspoons two or three times a day. The course of treatment lasts approximately five days. However, the exact dose will be determined by the doctor - it depends on the age of the child, the purpose of taking the drug (treatment or prevention) and other factors.

Medicines "Rematadine" for children: contraindications

Firstly, it is worth noting that the drug should not be given to a child under one year of age. The fact is that the kidneys at this age are not yet fully formed, so there is a risk of dangerous metabolites accumulating in the baby’s body.

In any case, this drug should not be prescribed to children with liver or kidney diseases. The fact is that these organs are involved in the metabolism of the active substances of the drug, so there is a risk severe consequences For child's body.

You should not use the drug "Remantadine" if you have hyperthyroidism, since the drug only aggravates the course of the disease and intensifies symptoms such as insomnia, irritability and tremors in the limbs. It is also not recommended to take the medicine for children with epilepsy, since the active substance can stimulate the development of seizures.

The drug "Remantadine" for children: side effects

In some cases, the child’s body reacts to taking the medicine with malfunctions digestive system. This may manifest as diarrhea, abdominal pain, nausea, vomiting, poor appetite. If all the signs are not too intense, then you should not stop taking it. If the side effects are very severe, it is recommended to stop taking the drug and seek medical advice.

Sometimes allergies in the form of rashes and hives are possible. Some children complain of drowsiness, headaches and heaviness in the body. If your child has a hard time taking this medicine, then you should stop using it and consult a doctor about analogues.