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Isofra spray: instructions for use. Isofra or Polydex - which is better for children? Shelf life of the drug Framycetin

Isofra spray is an antibiotic for local treatment acute and chronic sinusitis.

Used in otolaryngology. Has bactericidal properties. Active against pathogens localized in the upper respiratory tract.

On this page you will find all the information about Isofra: full instructions as applied to this medicine, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews from people who have already used Isofra spray. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibacterial drug for topical use in ENT practice.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

Prices

How much does Isofra cost? Average price in pharmacies it is at the level of 300 rubles.

Release form and composition

The medicine Isofra for the runny nose and some other infections of the ENT organs is available in the form of a spray. The manufacturer, the French pharmaceutical company Laboratoires Bouchara-Recordati, offers the medicine in 15 ml plastic bottles with a spray dispenser, additionally packaged in cardboard boxes.

The composition of the drug includes active substance framycetin in an amount of 12.5 mg per milliliter, as well as auxiliary components: distilled water, citric acid, sodium chloride and citrate, methylparaben. The average cost of one package in pharmacies is 300 rubles.

Pharmacological effect

Isofra has bactericidal effect, that is, destructive to pathogenic microorganisms. This drug affects many bacteria, both gram-positive and gram-negative.

Isofra is used in cases of damage to the upper respiratory tract by staphylococcus, Escherichia coli, Haemophilus influenzae, and Klebsiella.

Indications for use

Can be used in complex therapy infectious pathologies of the nasopharynx, namely:

Rhinopharyngitis.
(runny nose bacterial nature(for “green snot”).
(, etmoindit,).

The antibiotic is used in postoperative period to avoid inflammation, for example, with remote .

Contraindications

The use of drops and spray is contraindicated due to individual intolerance to antibiotics from the aminoglycoside group.

Use during pregnancy and lactation

Isofra during pregnancy can be prescribed by a doctor if there is potential benefit and the risk does not exceed the risk to the mother and fetus. The absorption of the antibiotic into the blood practically does not occur; therefore, the drug, as a rule, is not contraindicated in pregnant and lactating women.

Instructions for use

The instructions for use indicate that the spray is injected into each nostril after rinsing or cleansing the nose. The bottle should not be tilted while pressing the dispenser.

For adult patients, press the dispenser once four to six times a day.
For babies, press the dispenser once in each nostril three times a day.
Duration of use – up to ten days.

Drops should be administered into each nostril, one to two drops, four to six times a day into each nostril no more than once every two hours.

How to properly inject

To get maximum effect effect of the spray, it is necessary to first apply vasoconstrictor drops or sprays such as Naphthyzin, Galazolin, Xymelin 15-20 minutes before. When breathing becomes freer, try to clear the nasal passages by blowing your nose. Isofra spray is administered under strictly vertical position bottle. The dispenser is first inserted into one nostril and one injection is made into the nose, then the same is repeated on the opposite side.

You should not make several injections at once. This artificially increases the dosage of the antibiotic and provokes side effects. The course of treatment with Isofra for sinusitis is no more than a week. If there is no improvement, the drug is discontinued and another one is prescribed.

Side effects

Relative rarity side effects is explained by the local method of using Isofra, in which its adsorption capacity, and, consequently, its effect does not extend to the entire body as a whole. In reviews of Isofra, which accumulated during post-marketing studies, only allergic reactions. Overdose with adequate use of the drug is practically excluded.

Overdose

Overdose with adequate use of the drug is practically excluded.

Special instructions

At long-term use(more than 10 days), the possibility of disturbing the balance of the natural microflora of the nasopharynx should be taken into account. Should not be used for rinsing paranasal sinuses nose It should be remembered that during treatment, resistant strains of microorganisms may appear.

Drug interactions

It was not detected in laboratory conditions. However, the drug may reduce the effectiveness antifungal agents local action.

Reviews

We have selected some people's reviews about the drug Isofra:

Anastasia . Can be taken from 6 months. My son was also prescribed yellow snot, the snot went away quickly. But be prepared for the fact that the next time you have a runny nose, no drops will help you other than isofra. Antibiotic kills everything! Now my son and I are suffering from snot, we only treat it with antibiotics! It’s a shame I didn’t listen to the pharmacist and recommended not to take the terrible drops.
Elena. My son is 1.7 years old. I recently bought isofra because... The snot had been going on for 3 weeks already, it helped almost immediately, but on the 2nd day a terrible rash appeared all over my body and face, it stopped giving and everything went away. But the drug is very good, it cured my eldest son’s snot for a month in 2 days.
Alina. Isofroy always treats “complex green” snot in myself and my children - when ordinary nasal drops are powerless, it helps. It’s just important not to get carried away, because Isofra still contains an antibiotic.

Analogs

There are drugs with similar effects, which allows you to choose a cheaper, but no less effective drug.

Polydexa. Unlike Isofra, it contains two antibiotics at once, which expands the spectrum of action of the drug. Each component affects a specific group pathogenic microorganisms, which makes it possible to achieve more pronounced therapeutic effect. The product is available in the form of a nasal spray and ear drops.
Dioxidin. This antimicrobial agent It is produced in the form of a solution, which is sometimes recommended to be dripped for a runny nose or otitis media. In some cases, the doctor prescribes complex drops with this component.
Grippferon. Nasal drops that have antiseptic effect and quickly relieve the inflammatory process. The active ingredient in the drug is recombinant human interferon. The cost of the drops is 200-250 rubles.
Framinazine. A cheap synonym for Isofra, costing from 30 to 60 rubles. The drug contains the antibiotic framinazine. Children under 6 years of age and pregnant women can take the medicine, but with caution and under the supervision of a doctor.
Rhinostop. Cheap analogue Isofra, which also has antibacterial properties, relieves inflammation and can be used to treat respiratory infections. The cost of the drug is from 35 rubles.

Before using analogues, consult your doctor.

Isofra or Polydex – which is more effective?

Sometimes an analogue of Isofra is considered to be Polydex nasal spray. The same manufacturer - the French Laboratory Bouchard-Recordati, similar packaging design. However, these drugs are not the same thing. If you use nasal antibiotics, then you need to know how Isofra and Polydexa differ.

Polydexa contains two antibiotics, not one. Accordingly, the range of its application is wider than that of single-component Isofra;

Polydexa contains phenylephrine, an element with a vasoconstrictor effect;
Polydexa contains the corticosteroid dexamethasone with anti-inflammatory and antihistamine effects;
Polydexa, in addition to a nasal spray, is made in the form of ear drops and is successfully used in the treatment of otitis media.

Thus, Polydexa is more powerful complex drug with antibacterial, anti-inflammatory, vasoconstrictor effects. Therefore, it is impossible to say unequivocally what is better and more effective. But it is logical to start treatment with more simple drug, i.e. from Isofra. If it is ineffective, switch to Polydexa with the doctor’s permission.

Storage conditions and shelf life

The shelf life of Isofra spray is 3 years from the date of its manufacture. The drug must be stored out of the reach of children at an air temperature no higher than +25° C.

Analogues of the drug framycetin* are presented, in accordance with medical terminology, called “synonyms” - drugs that are interchangeable in their effects on the body, containing one or more identical active ingredients. When selecting synonyms, consider not only their cost, but also the country of production and the reputation of the manufacturer.

Description of the drug

Framycetin*- Antibiotic of the aminoglycoside group for local use in otorhinolaryngology. Has a wide range antibacterial action. Acts bactericidal. Active against a number of gram-positive and gram-negative bacteria. Resistance to framycetin develops slowly and to a small extent.

List of analogues

Pay attention! The list contains synonyms Framycetin* (Framycetin*), having similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from Eastern Europe: KRKA, Gedeon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Reviews

Below are the results of surveys of site visitors about the drug framycetin*. They reflect the personal feelings of those surveyed and cannot be used as an official recommendation for treatment with this drug. We strongly recommend that you contact a qualified medical specialist to select a personal course of treatment.

Visitor survey results

Visitor Performance Report

Two visitors reported side effects

	Participants		%
No side effects	2		100.0%

Visitor Cost Estimation Report

Information has not yet been provided

One visitor reported the frequency of intake per day

How often should I take Framycetin*?
Most respondents most often take this drug 2 times a day. The report shows how often other survey participants take this drug.

	Participants		%
2 times a day	1		100.0%

Visitor Dosage Report

Information has not yet been provided

Visitor start date report

Information has not yet been provided

Visitor report on reception time

Information has not yet been provided

Fourteen visitors reported the patient's age

Visitor reviews

There are no reviews yet

Official instructions for use

There are contraindications! Read the instructions before use

ISOFRA

Drug dossier

Registration number:
P N015454/01
Trade name: ISOFRA
INN: Framycetin*
Dosage form:
nasal spray
Compound per 100 ml
Active ingredient:
Framycetin sulfate...800,000 ME
Excipients: methylparaben, sodium chloride, sodium citrate, citric acid, purified water
Description: clear liquid
ATX code:
Pharmacotherapeutic group:
antibiotic from the aminoglycoside group

Pharmacological properties

Antibiotic from the group of aminoglycosides for topical use in otolaryngology.
Acts bactericidal. Active against most gram-positive and gram-negative bacteria ( Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae), causing development infectious processes in the upper sections respiratory tract.

Indications for use

Included combination therapy for infectious and inflammatory diseases of the upper respiratory tract, including:
- rhinitis;
- rhinopharyngitis;
- sinusitis (in the absence of damage to the septum).
Prevention and treatment inflammatory processes after surgical interventions.

Contraindications

Hypersensitivity to framycetin and other aminoglycoside antibiotics. The drug should not be used to rinse the paranasal sinuses. Pregnancy and period breastfeeding.

Directions for use and doses

For adults: one injection into each nostril 4-6 times a day.
For children: one spray into each nostril 3 times a day.
The duration of treatment is no more than 7 days.
When used, the bottle should be kept in an upright position.

Side effects

Allergic reactions are possible.

Drug interactions

No clinically significant interactions of the drug with other drugs have been identified.

Overdose

Due to the low degree of absorption into the systemic circulation, an overdose is unlikely.

Special instructions

It should be remembered that during treatment, resistant strains of microorganisms may appear.
PREGNANCY AND BREASTFEEDING
Contraindicated during pregnancy and breastfeeding.

Release form

Nasal spray: 15 ml light-proof polyethylene bottle with spray tip and polyethylene screw cap cardboard box.

Best before date

3 years.
Do not use after the expiration date stated on the packaging.

Storage conditions

List B.
At a temperature not exceeding 25 °C, out of the reach of children.

Vacation conditions

By doctor's prescription.
Manufacturer:

"BUSHARA-RECORDATI Laboratories"
68, rue Marjolin - 92300
Levallois-Perret France
Representative office in Moscow:
Krasnopresnenskaya embankment, 12,
WTC, "International-2".

The information on the page was verified by physician-therapist E.I. Vasilyeva.

Runny nose, sinusitis, sinusitis, pharyngitis - all this serious illnesses that require immediate treatment. They arise due to infection on the mucous membranes of the nose and paranasal sinuses. To eliminate these and other ailments, the most various means, including the drug “Isofra”, reviews of which say that it has repeatedly proven its effectiveness.

Characteristics of the drug "Isofra"

This medicine belongs to the class of antibiotics. It is used in the treatment of runny nose various forms and severity, as well as in the treatment of a number of other diseases of the upper respiratory tract. The spray is indicated for use by both children and adults. It has anti-inflammatory and antibacterial effects.

Release form and composition

The drug "Isofra", the reviews of which are very different, is produced in the form of a nasal spray with a dispenser that regulates the uniform intake medicinal substance into the nasal cavity. Thanks to this form, the medicine can reach the most hard to reach places. The drug contains the active ingredient - framycetin sulfate in the amount of 12.5 ml per 800,000 units. The volume of the bottle is 15 ml. The manufacturer of the drug is the French pharmaceutical company Bouchard-Recordati Laboratories.

The complete set includes:

paper box;
15 ml plastic container with the drug “Isofra”;
instructions.

Reviews about this product say that it can be bought at every pharmacy, it is sold only with a doctor's prescription and costs about 150 rubles.

Russian analogues

Many patients, before using Isofra spray, reviews of which are very diverse, look for Russian analogue, containing the same active ingredient, but the price of which is significantly lower. This category of people will be disappointed, because at the moment complete analogue this drug in Russia no.

In its properties, the medicine is similar to Bioparox, which contains an antibiotic component - fusafungin, and also has common features with Polidex, which contains antibiotics such as neomycin, polymyxin B and the corticosteroid dexamethasone. The latter also has a vasoconstrictor, antiseptic and antihistamine effect, which is very effective for allergies. Framinazin has a similar composition, which provides similar effect. This drug causes the death of pathogenic microbes and has an antiseptic effect.

A replacement for the drug “Isofra” can be “Protargol”, which is a good cure for runny nose and sinusitis. This medicine has a completely opposite composition and contains silver ions. "Protargol" is recommended for those people who are allergic to Isofra spray. Vibracil is no less effective for combating diseases of the upper respiratory tract. It relieves allergic nasal congestion and cures rhinitis different shapes, however, it has a lot of contraindications - these are vascular and heart diseases, diabetes mellitus, atrophy of the nasal mucosa, closed glaucoma and much more.

So if the doctor prescribed Isofra, then you should buy this particular drug. And you should not replace it yourself with another product.

Pharmacology of the spray

The bactericidal effect on pathogenic microorganisms is characteristic of the drug "Isofra". Reviews say that this process affects gram-positive and gram-negative bacteria. The drug has found its purpose in acute viral diseases upper respiratory tract associated with staphylococcal, Escherichia coli and Haemophilus influenzae, Klebsiella, Shigella, Proteus and a number of similar infections. The drug "Isofra", unfortunately, is absolutely powerless against diseases caused by treponema, anaerobic or streptococcal bacteria.

The active substance framycetin, penetrating deep into the cellular tissue of pathogenic microorganisms, reduces the synthesis of the protein they produce. As a result of this, pathogenic cells are destroyed and die, and the disease disappears without a trace.

Indications and contraindications for use

The drug has a narrow area of action and can be used in therapeutic treatment How independent remedy, and in combination with other medications. So, “Isofra” is effective for sinusitis (reviews keep saying this), as well as rhinitis, where the nasal mucosa suffers from infection. Good result was noticed with nasopharyngitis and other complicated forms of the runny nose. Isofra has a good effect for sinusitis. Reviews say that in this case you need to carefully read the instructions for the drug, which emphasize that the drug can be used only in the absence of all kinds of deformations in the nasal septum. The medicine is also used for such advanced forms of sinusitis as frontal sinusitis and ethmoiditis.

The spray is used for the prevention and treatment of postoperative inflammatory processes when the body's immunity is weakened. There is a special celebration here positive effect a drug that is not comparable to any other medicine.

In any case, self-prescription of this drug should be completely excluded, especially when treating baby runny nose. Reviews about Isofra confirm this aspect. For children, Komarovsky recommends using more gentle treatment methods and only in in rare cases resort to antibiotics of a similar nature.

Isofra nasal drops, reviews of which are not always positive, are prohibited from use:

with high sensitivity to antibiotics of the aminoglycoside group, including framycetin;
during pregnancy;
during breastfeeding;
under the age of 2.5 years;
with renal failure.

During pregnancy, the drug can disrupt embryonic development fetus, and it easily penetrates into breast milk, which negatively affects the child’s condition.

There is a small probability of suppression of the microflora of the nasal mucosa with the subsequent development of dysbiosis, which causes particular caution when using antibiotics, especially in childhood.

Spray "Isofra": instructions for use

Reviews about the drug say that its use must be supervised by a doctor, since this medicine is an antibiotic. Experts recommend using the spray for about a week, but no more than 10 days. If the patient’s condition has not improved during this time, another drug should be prescribed or the diagnosis of the current illness should be rechecked.

To use the drug, spray the spray into each nostril once. Adults should irrigate their nose with Isofra 5-6 times during the day. Reviews recommend that for children aged 2.5 to 15 years, the proportion should be halved, that is, used no more than three times a day, one spray into the nose.

During the procedure, the bottle is kept in an upright position to avoid getting the product into the eyes, ears or other area of the face. The head should be tilted slightly. Next, insert the tip of the dispenser into the nostril and press. The nasal cavity must first be cleared of crusts, mucus and thoroughly rinsed. Only in this case can the maximum effect be achieved.

Do not use Isofra for rinsing the nasal cavity for sinusitis, and also do not use medicinal product together with antifungal agents, as they reduce the effect of the antibiotic. If there is no result within three days, then you need to contact a specialist to review the already prescribed treatment.

Side effects

Due to the fact that Isofra drops (reviews about them are mostly positive) are used locally, the drug does not affect the entire body. Side effects when using it, it is practically not observed, only in some cases an allergic reaction to the antibiotic may occur. An overdose, if the instructions for use are followed, is completely excluded, since the drug is poorly absorbed in the nasal cavity and sinuses.

Special instructions for use

Before using Isofra spray to treat sinusitis, you need to undergo special examination see a doctor and undergo the appropriate tests. It would be a good idea to check the body’s reaction to the antibiotic in advance. In the absence of contraindications and provided the drug is prescribed by a doctor, you can safely use it in the treatment of runny nose in both children and adults.

It is worth strictly regulating the use of the drug "Isofra" and not using it often, since there is a possibility of the emergence of strains of microorganisms on which this drug cannot act.

The drug should be stored in a dark place, out of reach of children, at room temperature not exceeding 25°C. Expiry date within which to use this remedy, is three years.

"Isofra": reviews

For children, the instructions allow the use of the product from 2.5 years. The drug should be used strictly as prescribed by a doctor. This medicine saved many children from a persistent runny nose, when thick green snot flowed for several weeks. Even the most persistent rhinitis goes away two days after starting to use Isofra spray (reviews).

For children, Komarovsky recommends using other drugs, although he sees nothing wrong with using this particular spray. According to the doctor, the drug does not apply to systemic antibiotics and is not addictive. Komarovsky himself never prescribes this spray, as he considers the drug insufficiently effective and poorly studied.

Some people find the bottle impractical and very awkward to hold in an upright position. They also note a non-functional dispenser for the drug “Isofra” - reviews for children say that the stream flows unevenly from it.

There are parents who used Isofra spray to treat runny noses in children, but it did not bring any results. Negative reviews are usually associated with the use of the drug without a doctor’s prescription. In this case, it was used to treat allergic sinusitis or rhinitis. There have been cases when even the doctor’s recommendations did not help the medicine cope with the disease.

Adults note how effective Isofra is for sinusitis; reviews repeatedly confirm this. On a positive note It is also true that when treated with such a drug, you don’t have to take antibiotics or do injections, since the spray itself copes with harmful bacteria. Full recovery occurs already on the fifth day of using the drug.

Dr. Komarovsky is a practicing pediatrician, and few parents have not heard of him. It has its own children's clinic, and free time conducts research on infectious childhood diseases.

The pediatrician also paid attention to the topic of runny nose in children. According to him, there are no children who would not encounter this disease. He advises not to treat a runny nose, but to relieve the symptoms. In his opinion, snot is nothing more than the body’s reaction to pathogenic viruses, and along with the mucus that the nose generously produces, those bacteria that successfully fight infection are also released.

When the nasal sinuses are treated, pathogenic microbes freely penetrate into the body, provoking a more serious course of the disease. Therefore, Komarovsky advises keeping the child’s nasal mucosa moist in case of a runny nose. In addition, it is recommended to ensure that the temperature in the nursery is no higher than 21 ° C, and the air humidity varies within 75%.

Based on his many years of experience working with children, the doctor gives the following recommendations for diseases of the upper respiratory tract:

Humidify the air in the room where the child sleeps.
Every 2-3 hours, irrigate your nose with saline solution or a composition consisting of sea salt, dissolved in 250 ml of water.
Use the drug “Ectericide” to treat a runny nose, which has emollient and antiseptic properties.
For children under 3 years of age, the doctor recommends lubricating the nose with oil enriched vitamin complexes A and E.
It is impossible to treat a runny nose in children vasoconstrictor drugs, for example, “Naphthyzin”, “Xelen” and others. They alleviate the patient's condition only temporarily and can cause swelling of the nasopharynx.

Decide on the use of a particular drug in treatment certain disease only a doctor should. You should always remember that there is no harmless drugs even for topical use. Isofra spray may be useful only in the prescribed dose and subject to a certain period of treatment. You should never self-medicate, as the consequences similar actions often sad.

Structural formula

Russian name

Latin name of the substance Framycetin

Framycetinum ( genus. Framycetini)

Chemical name

(2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R ,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-( Hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol

Gross formula

C23H46N6O13

Pharmacological group of the substance Framycetin

Nosological classification (ICD-10)

CAS Code

119-04-0

Characteristics of the substance Framycetin

Antibiotic for local use from the group of aminoglycosides.

Pharmacology

Pharmacological action- antibacterial, bactericidal.

Damages the cytoplasmic membrane, disrupts the flow of metabolites inside the cell and causes rapid death of microorganisms.

Active against gram-positive microorganisms - Staphylococcus spp.(resistant to penicillins and other antibiotics), some strains Streptococcus spp., gram-negative bacteria Pseudomonas aeruginosa, Klebsiella spp., Enterobacter spp., Salmonella spp.Shigella spp. Proteus spp., causing the development of infectious and inflammatory processes in the upper respiratory tract. Resistant to framycetin Treponema spp., some strains Streptococcus spp., anaerobic microorganisms.

At local application systemic absorption is low.

Use of the substance Framycetin

Infectious and inflammatory diseases of the upper respiratory tract and ENT organs, incl. rhinitis, nasopharyngitis, sinusitis; prevention and treatment of postoperative infections.

Contraindications

Hypersensitivity (including to other aminoglycosides), pregnancy and breastfeeding (adequate safety studies have not been conducted).

Side effects of the substance Framycetin

Skin allergic reactions, superinfection (when used for more than 10 days).

Routes of administration

Intranasally.

Precautions for the substance Framycetin

With long-term (more than 10 days) therapy, dysbiosis and the emergence of resistant strains are possible. Should not be used to rinse the paranasal sinuses. Lack of improvement within 7-10 days requires a change in treatment.