Lopedium is a potent antidiarrheal drug. Antidiarrheal drug Loperamide Lopedium - “Say NO to diarrhea! And to constipation - YES! (instructions for use, side effects)"
D I think everyone can remember a case in their life (and more than one) when an intestinal disorder in the form of diarrhea took you by surprise. Usually this happens before some important exciting moment (wedding, long-awaited trip, meeting, exam, and so on). In my own way, I call it nervous diarrhea (as I get it due to excessive anxiety). In this case, Lopedium (Loperamide) helps me out, by drinking which I can be 100% sure that my diarrhea will go away.
ABOUT taking a pill can solve the problem frequent visits toilet in a maximum of half an hour, and you can forget about diarrhea.
IN This would be fine, of course, but there is one minus that I can’t help but mention. You forget about diarrhea, but you also forget about the need to go to the toilet for “big” errands for the next two days. Not always, but still this happens often after Lopedium. Along with constipation, bloating also occurs. Not a very pleasant feeling. This is one minus that I found in Lopedium.
N but in fact there are 10 tablets in a package. Some of the tablets are missing from the photo, as they are in the bag just in case)
P The antidiarrheal drug Lopedium is available in the form of tablets and capsules. The instructions for using Lopedium for these two types are the same, the only difference is in the composition of the excipients.
TO The capsule and tablet are small and can be swallowed without experiencing discomfort in the throat.
P Before use, pay attention to contraindications to avoid harming yourself:
Increased sensitivity to the components of the drug;
I trimester of pregnancy;
Lactation period;
Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
Children under 6 years of age;
As monotherapy for dysentery and other gastrointestinal infections;
Bacterial enterocolitis;
Ulcerative colitis in the acute stage;
Diarrhea due to acute pseudomembranous enterocolitis;
Intestinal obstruction
WITH caution the drug should be used in patients with liver failure.
P during pregnancy , as already mentioned, the use of the drug Lopedium is contraindicated only in the first trimester. However, before using it in the second and third trimester, you should consult your doctor, since the risk of negative effects on the fetus cannot be ruled out.
WITH method of application : The tablet (or capsule) should not be chewed, it must be swallowed and washed down with half a glass of water. Lopedioem can only be taken by children over 6 years of age, strictly according to the instructions.
T Since the drug causes side effects in me, it is possible that, depending on the characteristics of the body, other symptoms may appear.
P Side effects of Lopedium :
P The drug may cause dizziness, drowsiness and fatigue, so you should not drive immediately after taking it. Drivers should take it with caution when driving.
C ena Lopedium very attractive indeed. I bought it for 27.30 rubles.
E Another well-known cure for diarrhea.
Mezim - help your digestion
Ceftriaxone - antibiotic wide range actions
My use of Chamomile for colds and more.
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Conclusion:
P I recommend taking Lopedium for diarrhea. It does its job very well. There is no difference in the effect of capsules and tablets, so you can buy both depending on your preferences (some people cannot swallow capsules, in which case tablets are perfect).
M maybe side effect in the form of constipation and bloating. For this reason, it should not be abused. If you have the opportunity and you don’t have to go anywhere, I still advise you to go on a diet that day without taking pills.
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Antidiarrheal symptomatic drug.Drug: LOPEDIUM
Active substance: loperamide
ATX code: A07DA03
KFG: Antidiarrheal symptomatic drug
Reg. number: P No. 015863/01
Registration date: 07.26.04
Owner reg. cert.: HEXAL AG (Germany)
DOSAGE FORM, COMPOSITION AND PACKAGING
? Capsules hard gelatin, with body gray and a dark green cap; the contents of the capsules are white homogeneous powder.
Excipients: lactose monohydrate, corn starch, talc, magnesium stearate.
? Pills white or almost white, round, convex on one side and with a score on the other, the surface is beveled towards the score.
Excipients: lactose monohydrate, calcium hydrogen phosphate dihydrate, corn starch, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate.
10 pcs. - blisters (1) - cardboard packs.
10 pcs. - blisters (2) - cardboard packs.
10 pcs. - blisters (3) - cardboard packs.
10 pcs. - blisters (5) - cardboard packs.
The description of the drug is based on the officially approved instructions for use.
PHARMACOLOGICAL ACTION
Antidiarrheal symptomatic drug.
By binding to opioid receptors in the intestinal wall, loperamide reduces tone and motility smooth muscle intestines. Slows down peristalsis and increases the transit time of intestinal contents. Increases tone anal sphincter. Helps retain feces and reduce the urge to defecate.
The action occurs quickly and lasts for 4-6 hours.
PHARMACOKINETICS
Suction
Absorption of loperamide - 40%. The time to reach Cmax is 2.5 hours.
Distribution
Plasma protein binding - 97%. Does not penetrate the BBB.
Metabolism
Almost completely metabolized in the liver by conjugation.
Removal
It is excreted primarily in bile and urine. T 1/2 is 9-14 hours.
INDICATIONS
Symptomatic treatment of acute and chronic diarrhea allergic, emotional, medicinal and radiation origin;
Diarrhea when changing diet, quality composition food, malabsorption and metabolism;
As an adjuvant for diarrhea of infectious origin;
Regulation of bowel movements in patients with ileostomy.
DOSING REGIME
The drug should be taken orally, tablets and capsules should be swallowed without chewing, with 100 ml of water.
For adults at acute and chronic diarrhea prescribed initially 4 mg, then 2 mg after each act of defecation in case of loose stool. Maximum daily dose- 16 mg.
Children over 6 years old Prescribe 2 mg after each bowel movement in case of loose stools. The maximum daily dose is 6 mg.
After normalization of stool or in the absence of stool for more than 12 hours, treatment should be discontinued.
SIDE EFFECTS
From the outside digestive system: dry mouth, nausea, vomiting, stomach pain, intestinal colic, constipation; very rarely - intestinal obstruction.
From the side of the central nervous system: drowsiness or insomnia, dizziness, headache.
Allergic reactions: skin rash.
CONTRAINDICATIONS
Diverticulosis;
Intestinal obstruction;
Ulcerative colitis in the acute stage;
Diarrhea due to acute pseudomembranous enterocolitis;
Monotherapy for dysentery and other gastrointestinal infections;
I trimester of pregnancy;
Lactation period;
Children under 6 years of age;
Hypersensitivity to the components of the drug.
WITH caution the drug should be used in patients with liver failure.
SPECIAL INSTRUCTIONS
If there is no effect after 2 days of using Lopedium, it is necessary to clarify the diagnosis and exclude infectious genesis diarrhea.
If constipation or bloating develops during treatment, the drug should be discontinued.
In patients with impaired liver function, careful monitoring of signs is necessary toxic damage CNS.
During the treatment period, it is necessary to replenish the loss of fluid and electrolytes.
Each Lopedium tablet or capsule corresponds to 0.01 XE.
Impact on the ability to drive vehicles and operate machinery
If drowsiness or dizziness occurs, you should refrain from driving vehicles and working with machinery.
OVERDOSE
Symptoms: stupor, loss of coordination, drowsiness, miosis, muscle hypertonicity, respiratory depression, intestinal obstruction.
Treatment: symptomatic - activated carbon, gastric lavage, mechanical ventilation. Medical observation of the patient is necessary for at least 48 hours. The antidote is naloxone. Because loperamide has a longer duration of action than naloxone, it is possible reintroduction the last one.
DRUG INTERACTIONS
Clinically significant interactions of loperamide with other medicines not installed.
CONDITIONS OF VACATION FROM PHARMACIES
The drug is approved for use as an over-the-counter product.
CONDITIONS AND DURATION OF STORAGE
The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 5 years.
1 tablet contains: Loperamide hydrochloride 2 mg. Excipients: Lactose, calcium hydrogen phosphate, corn starch, sodium starch glycolate, colloidal silicon anhydride, magnesium stearate.
1 capsule contains: Loperamide hydrochloride 2 mg. Excipients: Lactose, corn starch, talc, magnesium stearate.
Description
White or almost white round tablets, convex on one side, with a score on the other side, the surface of the tablet is beveled towards the score.
Solid gelatin capsules filled with white homogeneous powder. Bottom part capsules are gray, the top one is dark green.
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Pharmacological action
The drug affects the contraction of the muscles of the intestinal wall, slows down the passage of intestinal contents by inhibiting peristalsis. Increases the tone of the anal sphincter, promotes fecal retention and reduces the frequency of the urge to defecate.
Pharmacokinetics
Due to its high affinity for the intestinal wall and high degree biotransformation during the first passage through the liver, practically does not enter the systemic circulation. Metabolized in the liver. Excreted in bile and feces. The half-life is 9-14 hours (average 11).
The average duration of action is 4-6 hours.
Indications for use
Symptomatic treatment of acute and chronic diarrhea of various origins(allergic, emotional medicinal, radiation; with changes in diet and quality composition of food, with metabolic and absorption disorders; as an adjuvant for diarrhea of infectious origin).
Regulation of bowel movements in patients with ileostomy.
Contraindications
Hypersensitivity to the drug
Diverticulosis
Diarrhea accompanied high fever and bloody stool
Intestinal obstruction
Antibiotic-associated diarrhea caused by Closrtidium difficile, acute pseudomembranous colitis (idiopathic antibiotic-associated diarrhea is not a contraindication to loperamide)
Ulcerative colitis in the acute stage
As monotherapy for dysentery and other gastrointestinal infections
Pregnancy (1st trimester)
Lactation period.
The drug is contraindicated for children under 2 years of age. For children from 2 to 8 years old, loperamide is prescribed in other dosage forms (syrup, solution)
Prescribe with caution in case of liver failure.
Pregnancy and lactation
There is insufficient data on use in pregnant women. However, the drug is contraindicated for use in the 1st trimester of pregnancy and lactation. Use in the 2nd and 3rd trimester is possible if the expected benefit to the mother outweighs the potential risk to the fetus.
Directions for use and doses
Inside, swallow tablets and capsules without chewing with 100 ml of water. For adults with acute and chronic diarrhea, 4 mg is initially prescribed, then 2 mg after each bowel movement in case of loose stools. The maximum daily dose is 16 mg. Children over 8 years of age are prescribed 2 mg after each bowel movement in case of loose stools. The maximum daily dose is 6 mg.
Children from 2 to 8 years old are prescribed 0.04 mg/kg per day in other dosage forms (syrup, solution)
After normalization of stool or if there is no stool for more than 12 hours, treatment should be discontinued.
If diarrhea persists for more than 48 hours while taking the drug, it is necessary to clarify the diagnosis.
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Side effect
Headache, arthralgia, dry mouth, allergic reactions(skin rash), drowsiness or insomnia, dizziness, intestinal colic, nausea, vomiting, constipation. Extremely rare - intestinal obstruction.
Overdose
Central nervous system depression (stupor, loss of coordination, miosis, drowsiness, muscle hypertonicity, respiratory depression), intestinal obstruction.
The antidote is naloxone. Given the short duration of action of naloxone, repeated administration of the latter is possible.
Symptomatic treatment - gastric lavage, activated carbon, mechanical ventilation. Medical supervision is required for at least 48 hours.
Interaction with other drugs
At simultaneous administration loperamide with verapamil, quinidine, ritonavir (HIV protein kinase inhibitors), ketoconazole, cases of respiratory depression may occur
3D images
Compound
| Capsules | 1 caps. |
| active substance: | |
| loperamide hydrochloride | 2 mg |
| excipients: lactose monohydrate - 127 mg; corn starch - 40 mg; talc - 9 mg; magnesium stearate – 2 mg | |
| hard gelatin shell | |
| frame: gelatin - 28.33 mg; iron (III) oxide black (E172) - 0.12 mg; titanium dioxide - 0.35 mg | |
| cap: gelatin - 18.68 mg; iron (III) oxide yellow (E172) - 0.23 mg; blue dye (E131) - 0.03 mg; iron (III) oxide black (E172) - 0.068 mg; titanium dioxide (E171) - 0.192 mg |
Description of the dosage form
Capsules: hard gelatin, the contents of the capsules are white homogeneous powder. The capsule body is gray, the cap is dark green.
Pills: white or almost white round, convex on one side, on the other side of the score, the surface of the tablet is beveled towards the score.
Pharmacological action
Pharmacological action- antidiarrheal, obstipating.Pharmacodynamics
By binding to opioid receptors of the intestinal wall, it suppresses the release of acetylcholine and PG, thereby reducing the tone and motility of intestinal smooth muscles. Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter. Helps retain feces and reduce the urge to defecate, reduces the frequency of bowel movements. The action occurs quickly and lasts 4-6 hours.
Pharmacokinetics
Loperamide undergoes first-pass metabolism, causing low bioavailability of the drug when orally. Tmax - 3-5 hours. Loperamide in trace amounts penetrates the BBB, which does not have a clinically significant effect. 1/3 of loperamide is excreted from the body unchanged, the rest is excreted in the form of metabolites by the intestines. Less than 2% of the active substance is excreted unchanged through the kidneys. T 1/2 - 7-15 hours.
Indications for the drug Lopedium ®
symptomatic treatment acute and chronic diarrhea of various origins (including allergic, emotional, radiation; with changes in diet and quality of food, metabolic and absorption disorders; medicinal, with the exception of antibiotic-associated diarrhea);
regulation of stool in patients with ileostomy.
Contraindications
hypersensitivity to loperamide and/or any of the components of the drug;
lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
acute dysentery;
bacterial enterocolitis caused by Salmonella, Shigella And Campylobacter;
acute pseudomembranous enterocolitis (diarrhea due to the use of antibiotics);
ulcerative colitis in the acute stage;
intestinal obstruction (including in cases where suppression of intestinal motility should be avoided due to the risk of developing severe consequences such as megacolon or toxic megacolon);
pregnancy (first trimester);
lactation period;
children under 6 years of age.
With caution: liver failure.
Use during pregnancy and breastfeeding
The use of the drug in the first trimester of pregnancy is contraindicated. Before using the drug during pregnancy (II and III trimesters) and lactation, you should consult your doctor. Despite the absence of indications of teratogenic or embryotoxic effects, the drug can be prescribed during pregnancy only if the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
Drug in small quantities stands out in breast milk Therefore, the use of the drug during lactation is contraindicated.
Side effects
According to WHO unwanted reactions classified according to their frequency of occurrence as follows: very common (≥1/10); often (≥1/100,<1/10); нечасто (≥1/1000, <1/100); редко (≥1/10000, <1/1000) и очень редко (<1/10000); частота неизвестна — по имеющимся данным установить частоту возникновения не представлялось возможным.
From the immune system: rarely - hypersensitivity, anaphylactic shock.
From the nervous system: often - headache, dizziness; infrequently - drowsiness; rarely - loss of consciousness, stupor, depressed level of consciousness, hypertension, loss of coordination.
From the senses: rarely - miosis.
From the digestive system: often - constipation, flatulence, nausea; uncommon - pain or discomfort in the abdomen, dry mouth, vomiting, indigestion, dyspepsia; rarely - intestinal obstruction, megacolon, glossalgia, bloating.
From the urinary system: rarely - urinary retention.
For the skin and subcutaneous tissues: infrequently - skin rashes; rarely - bullous rash (including erythema multiforme, toxic epidermal necrolysis and Stevens-Johnson syndrome), angioedema, urticaria, itching.
Other: rarely - fatigue.
Interaction
When taking loperamide and inhibitors of P-glycoprotein, CYP3A4 or CYP2C8(quinidine, ritonavir, itraconazole, gemfibrozil, ketoconazole) the plasma level of loperamide may increase.
When taking loperamide and desmopressin for oral administration simultaneously, the plasma level of the latter may increase.
Drugs with similar pharmacological properties may enhance the effect of loperamide; drugs that enhance the transit of food through the gastrointestinal tract weaken its effect.
Directions for use and doses
Inside. Swallow tablets and capsules without chewing with 100 ml of water.
Acute diarrhea
Adults:
Children from 6 to 18 years old: initially prescribed 1 capsule/table. (2 mg) per day, then 1 capsule/table. (2 mg) after each bowel movement in case of loose stools.
Chronic diarrhea
Adults: initially prescribed 2 capsules/table. (4 mg) per day, then 1 capsule/table. (2 mg) after each bowel movement in case of loose stools.
Children from 6 to 18 years old: initially prescribed 1 capsule/table. (2 mg) per day, then 1 capsule/table. (2 mg) after each bowel movement in case of loose stools. This dose is then individually adjusted so that the stool frequency is 1-2 times a day, which is usually achieved with a maintenance dose of 1 to 6 capsules/tablet. per day.
The maximum daily dose for acute and chronic diarrhea for adults is 16 mg (8 caps/tablet). In children, the maximum daily dose is calculated based on body weight (3 capsules/tablet per 20 kg) up to 8 capsules/tablet. per day.
Elderly patients and renal failure. No dose adjustment is required.
After normalization or in the absence of stool for more than 12 hours, treatment should be stopped.
The duration of treatment is 2 days. If symptoms persist for more than 24 hours, you should immediately consult a doctor.
Long-term use of the drug is possible only under the supervision of a doctor.
Overdose
Symptoms: CNS depression (stupor, loss of coordination, drowsiness, miosis, muscle hypertonicity, respiratory depression), urinary retention, intestinal obstruction.
Treatment: antidote - naloxone; Given that the duration of action of loperamide is longer than that of naloxone, repeated administration of the latter is possible. Medical observation is required for at least 48 hours.
Special instructions
Lopedium ® is used for the symptomatic treatment of diarrhea. If the cause of the disease is established, targeted therapy should be carried out.
Patients suffering from diarrhea, especially children, may experience hypovolemia and decreased electrolyte levels. In such cases, replacement of electrolyte loss and rehydration are essential.
If there is no improvement in acute diarrhea after using the drug for 48 hours, you should consult a doctor.
If bloating develops during the treatment of diarrhea in patients with AIDS, the drug should be discontinued immediately. In very rare cases, patients diagnosed with AIDS who suffer from infectious colitis may experience constipation with the risk of toxic megacolon.
Lopedium ® should be used with caution in case of liver failure to avoid toxic damage to the central nervous system.
If constipation, bloating or intestinal obstruction develops during treatment, the drug should be discontinued.
Instructions for patients with diabetes mellitus: each capsule/tablet corresponds to 0.01 XE.
Impact on the ability to drive vehicles and operate machinery. During treatment with Lopedium ®, caution must be exercised. When using the drug, you may experience a feeling of fatigue, dizziness, and drowsiness.
Release form
Capsules, 2 mg. In blister packs made of PVC/aluminum foil or polypropylene/aluminum foil, 10 pcs. 1, 2, 3 or 5 bl. in a cardboard box.
Tablets, 2 mg. In blister packs made of PVC/aluminum foil or propylene/aluminum foil, 10 pcs. 1, 2, 3 or 5 bl. in a cardboard box.
Manufacturer
Marketing authorization holder: Sandoz d.d. Verovškova 57, 1000, Ljubljana, Slovenia.
Manufactured by Salutas Pharma GmbH. Otto-von-Guericke Alee 1, 39179 Barleben, Germany.
Lopedium is an effective antidiarrheal drug that belongs to the group of peripheral opioid receptor agonists. The main active substance is loperamide. The drug inhibits peristalsis, increases sphincter tone and makes the process of passing feces longer. Reduces the number of urges to defecate and the acts themselves. It is used to treat acute and chronic forms of diarrhea (emptying the intestines with liquid feces) of various origins, including infectious and allergic in nature. The medicine is also prescribed to patients with ileostomy to normalize stool. It acts very quickly and retains the effect for up to 6 hours.1. Pharmacological action
A drug that has an antidiarrheal effect. Reduces the tone and motor activity of the smooth muscles of the intestinal wall, slows down the natural fluctuations of the digestive system and increases the tone of the anal sphincter. The use of Lopedium helps to retain feces and reduce the urge to go to the toilet.2. indications for use
- acute and chronic course of allergic, medicinal, radiation or emotional origin;
- Diarrhea of infectious origin (as an additional drug);
- caused by various nutritional disorders;
- Regulation of bowel movements in patients with ileostomy.
3. Method of application
Recommended dosage of Lopedium for:- pediatric patients over six years of age: 2 mg of the drug after each occurrence of loose stools;
- adult patients: 4 mg of the drug (initial dosage), then 2 mg of the drug after each case of loose stool.
- After diarrhea stops or if there is no stool for 12 hours, use should be discontinued;
- If there is no therapeutic effect during use, it is necessary to clarify the origin of diarrhea;
- If constipation or bloating develops, treatment should be discontinued;
- During treatment, you should take increased amounts of fluid.
4. Side effects
- Central nervous system: sleep disturbances, headaches, dizziness;
- Hypersensitivity reactions: skin rashes;
- Digestive system: pain in the stomach, nausea, colicky abdominal pain, intestinal obstruction, dry mouth, vomiting, constipation.
5. Contraindications
6. During pregnancy and lactation
Use of Lopedium in the first trimester of pregnancy strictly contraindicated.The use of Lopedium during breastfeeding is possible only after stopping it for the entire duration of Lopedium use.
7. Interaction with other drugs
No negative drug interactions have been described with Lopedium.8. Overdose
- Central nervous system: impaired coordination of movements, constriction of the pupil, respiratory depression, stupor, drowsiness, increased muscle tone;
- Digestive system: intestinal obstruction.
9. Release form
Capsules, 2 mg - 10, 20, 30 or 50 pcs.Tablets, 2 mg - 10, 20, 30 or 50 pcs.
10. Storage conditions
Lopedium should be stored in a dry place.11. Composition
1 tablet:
- Excipients: lactose monohydrate, calcium hydrogen phosphate dihydrate, corn starch, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate.
1 capsule:
- loperamide hydrochloride - 2 mg;
- Excipients: lactose monohydrate, corn starch, talc, magnesium stearate.
12. Conditions for dispensing from pharmacies
The drug is available without a prescription.Found a mistake? Select it and press Ctrl + Enter
* Instructions for medical use of the drug Lopedium are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, YOU MUST CONSULT WITH A SPECIALIST
