Actovegin: ointment for topical use.

Actovegin ointment is used as medicinal substance to eliminate trophic processes in the human body. The drug can be used to cure various diseases, including the organs of vision.

Actovegin ointment is available in tubes ranging from 20 to 100 grams. They are packed in cardboard boxes, which also contains instructions for use. Main active ingredient- hemoderivative from the blood of calves. One hundred grams of the product contains about 5 milliliters. It also contains auxiliary components:

• propyl parahydroxybenzoate - this substance can be found in plants or certain types insects, can have a strong antimicrobial effect and inhibit the growth of bacteria or fungi;
• methyl parahydroxybenzoate - helps prevent the development of bacteria and can have a disinfecting effect, the substance is not dangerous to humans and is independently eliminated from the body;
• peptides and amino acids - belong to physiological compounds and are not dangerous to the body.
• cetyl alcohol - protects the code from microbes and ultraviolet radiation;
• paraffin - has a dermatoprotective effect, protects the skin, softens it and makes the healing process faster;
• water.

This ointment has no analogues or contraindications for use. The product can have a beneficial effect on the body and accelerate metabolic processes in it.

Despite the fact that the drug does not have negative influence, it is recommended to start using it only after consulting a doctor.

The substance belongs to such drugs that can affect the body by cellular level. The ointment can activate transport function, resulting in an accumulation of oxygen and glucose in the tissues. Therefore, metabolism accelerates and the ability of cells to regenerate increases.

Action

The ointment is an antihypoxane. When the metabolic process is disrupted or increased energy consumption occurs, the substance stimulates and brings all functions back to normal. The ointment is well absorbed by cells.

Usually the product is used topically for external use. After use positive effect can be noticed within 10-15 minutes. It can work for 2-3 hours.

So, let's figure out why the ointment is prescribed. It has the following effect:

• heals wounds;
• improves tissue trophism;
• improves recovery processes;
• increases the flow of oxygen to tissues;
• stops bleeding;
• relieves inflammation;
• enhances the body's potential;
• improves the sensitivity of nerve endings.

Thanks to these features, the drug can be used to treat hypoxia or ischemia, when there is a lack of glucose or oxygen in the body’s tissues.

Indications for use

Often consumers do not know exactly what the drug helps with. The instructions for using the ointment state that it is used when and to eliminate:

• ulcers and wounds;
• bedsores;
• burns;
• skin grafting;
• eye damage;
• disruption of metabolic processes;
• insufficient blood circulation;
• venous insufficiency;
• hemorrhoids.

Based on these features, we can say that it is used in many medical profiles, and not just for eye treatment. It could be:

• ophthalmology;
• dentistry;
• phlebology;
• proctology;
• dermatology.

Instructions

The instructions for use for the ointment say that it should be used as follows:

1. The course of treatment is at least 12 days.
2. You need to apply the ointment at least 2 times a day.

• For ulcers and wounds of the skin and mucous membranes: use Actovegin 5%, apply in a thin layer.
• Bedsores and their prevention: rub into the right places.
• To prevent the appearance of radiation injuries: apply a thin layer of 5% ointment immediately after radiation therapy; this should be done in between procedures.

If desired effect does not occur after applying the ointment, you should consult a specialist.

Contraindications

The medicine is used to treat many diseases.

Children are also allowed to use it, but only a doctor can prescribe it after full examination and taking into account all risks. Application is carried out only locally. In some cases, children this remedy poorly tolerated, just like during pregnancy.

Side effects

Typically, patients who have used the substance note its effectiveness. In some cases, the product may have a negative effect on the body. The whole point is that the substance contains elements of animal origin, which can cause allergies.

Most common negative impacts are as follows:

• rash;
• rush of blood to the head;
• increase in temperature;
• increased sweat production.

If such symptoms appear, then the use of the medicine should be discontinued. You must also remember that during initial use of the product it may cause minor painful sensations, but this should not be a reason to cancel the use of the substance. This pain is usually caused by regeneration processes. These sensations go away on their own.

Rash is a possible side effect

Contraindications

The description of the ointment says that it cannot be used for:

• pulmonary edema;
• diabetes;
• sensitivity to components;
• oliguria;
• disorders in the respiratory system.

The ointment is prescribed with caution during pregnancy and children.

Currently, scientists have not yet figured out how the substance interacts with other drugs. There were no cases of overdose either. After using the product, you can drive a car, as it does not reduce reaction or impair the clarity of vision.

Analogs

The ointment also has cheaper analogues that are similar in action. You cannot prescribe one of these remedies yourself; only a doctor can do this:

• - makes the skin healing process faster.
• Algofin - prescribed for skin lesions caused by radiation, abscesses and fistulas.

Which analogues are best to choose, including during pregnancy, is determined only by a doctor. Experts often prefer Solcoseryl.

Price

One of the most frequently asked questions for patients - how much the medicine costs. This ointment is quite cheap, the cost does not exceed 150 rubles. Prices in pharmacies may vary, but most often do not exceed 200 rubles.

The price of substitutes is also quite reasonable. So, Solcoseryl costs about 250 rubles per package.

Actovegin is a hemoderivative drug that stimulates tissue metabolic processes, activates trophism, and improves regenerative functions.

Composition, release form

Actovegin is a sterile solution for injection; gel 20% for external use.

Solution for injection

One milliliter of sterile solution contains:

• Main active substances: hemoderivat, deproteinized, isolated from the blood of calves - 40 mg, sodium chloride - 26.8 mg.
• Additional component: water.

Package. Dark glass ampoules of 5 or 10 ml (5 pcs.). Cardboard box with instructions.

Gel

One gram of gel contains:

• Main active substance: hemoderivat isolated from the blood of calves, deproteinized – 8 mg.
• Additional components: sodium carmellose, calcium lactate, propylene glycol, propyl parahydroxybenzoate, methyl parahydroxybenzoate, water.

Package. Aluminum tubes of 20, 30, 50, 100 g.

Pharmacological action

Actovegin is a hemoderivative isolated from the blood of calves by dialysis and ultrafiltration. At the same time, Actovegin is an antihypoxant that can have a positive effect on the transport and utilization of glucose. It stimulates oxygen consumption (which helps stabilize plasma membranes during ischemia, as well as reducing the formation of lactates). Its antihypoxic effect occurs 30 minutes after injection, reaching its maximum possible after three hours.

Indications for use

Application in ophthalmology:

• Actovegin injections are prescribed to normalize increased intraocular pressure, the growth of which causes heaviness and pain in the eyes. Similar condition leads to blurry, unclear vision, which quickly returns to normal after administration.
• Actovegin gel is recommended for injuries of the cornea or sclera; ulcers and burns of the cornea of various origins, with keratitis (including those arising after corneal transplantation), with radiation injuries, changes in the corneal epithelium inherent in users contact lenses(for prevention purposes, among other things).

Directions for use and doses

Actovegin solution is used intra-arterially, intravenously (including infusion), intramuscularly; gel - externally. Administration of the drug may be potentially dangerous due to the occurrence of anaphylactic reactions, therefore, its use is possible only after a sensitivity test (up to 2 ml IM).

The initial injection dose of Actovegin is 10 - 20 ml/day, it is prescribed intravenously or intra-arterially, depending on the severity of the condition; then the dose is reduced to 5 ml intravenously or intramuscularly.

For infusion administration To the main solution (200-300 ml of 5% dextrose / 0.9% sodium chloride), you need to add 10-20 ml of Actovegin solution. The injection is carried out at a rate of up to 2 ml/min.

Actovegin gel is applied daily several times in a thin layer to the affected areas. Cleansing the ulcer surface requires pre-treatment, when the gel is applied in a thick layer to the wound and covered with a compress. On a very wet surface, gauze bandage change at least once a day.

Contraindications

• Individual hypersensitivity.
• Heart failure (decompensated);
• Pulmonary edema;
• Oliguria, anuria, fluid retention;

Actovegin should be prescribed with caution in case of hyperchloremia and hypernatremia.

Side effects

Allergic reactions (including hyperthermia, rash, skin flushing), up to the development of anaphylactic shock.

Overdose

No data available.

Interaction with other tools

Unknown.

Storage conditions and special instructions

Intramuscular injections of the drug provide a dosage limit of 5 ml. The introduction should be done slowly.

It is prohibited to use an opaque solution of Actovegin or a solution containing undissolved inclusions.
You should not wear contact lenses during treatment.
Opened ampoules with solution cannot be stored.
Shake the bottle vigorously before use.
Actovegin is stored in a dark place at room temperature.

Shelf life - 5 years.

Analogues of Actovegin

An analogue of Actovegin for use in ophthalmology is the drug Solcoseryl.

Drug price

Actovegin price in Russian pharmacies: gel - 150 rubles, solution for injection - 600 rubles.

Reviews about the drug Actovegin

If you are an ophthalmologist who has used the drug in your practice, a patient or a relative of a person who has used the drug Actovegin, we will be grateful if you leave your feedback about this medicine.

Actovegin (eye gel): instructions for use, reviews and analogues, prices in pharmacies

"Actovegin" is a drug that activates metabolism in tissues, stimulates regeneration processes and improves trophism. Available in the form of a solution for injection, solution for infusion, film-coated tablets, as well as in the form of ointment and gel.

In ophthalmology, eye gel is used. It is used for burns, corneal ulcers of various origins and for the treatment and prevention of radiation damage to the cornea.

Release form and composition

The drug is available in five gram tubes, packaged in cardboard boxes, instructions are included. Actovegin eye gel is a homogeneous, transparent mass, colorless or slightly yellowish.

Its active substance is deproteinized hemoderivative from calf blood (dry mass) (eight milligrams). Auxiliary components include carboxymethylcellulose, sorbitol, lactic acid, thiomersal.

Pharmacological action

This drug helps to activate metabolism in tissues, improves trophism and stimulates regeneration processes. In ophthalmology it is used topically.

"Actovegin" activates cell metabolism by increasing the transport rate and further accumulation of oxygen and glucose, enhancing intracellular utilization.

As a result, there is an increase in the energy resources of the cell, especially under conditions of ischemia and hypoxia.

Pharmacokinetics

It is impossible to study the pharmacokinetic characteristics (absorption, distribution, excretion) of a drug, since it consists of physiological components that are usually present in the human body.

Yes today no decrease in indicator was detected pharmacological activity active substance in patients with altered pharmacokinetics (including renal and liver failure, age-related metabolic changes).

Indications for use

Actovegin eye gel is used:

• to eliminate corneal ulcers of various origins;
• for the treatment of corneal burns (lime, alkali, acid);
• for the purpose of prevention and treatment of radiation injuries of the cornea;
• for defects of the corneal epithelium in patients using contact lenses;
• for the prevention of lesions during the selection of contact lenses in patients with atrophic and dystrophic processes in the cornea (including age-related atrophic keratitis).

Dosage and method of administration

The drug is intended exclusively for local application. One or two drops of gel are squeezed directly from the tube into the affected eye.

The frequency of application is from one to three times per day. The duration of treatment is determined by the indications.

Side effects

Side effects of the eye gel include the development of reactions allergic type, which are observed quite rarely.

Contraindications

Contraindications to the use of this drug include hypersensitivity to one or more of its components.

Use during pregnancy and lactation

The use of the drug "Actovegin" during lactation and pregnancy is allowed only if indicated.

Overdose

There are no reports of cases of overdose with eye ointment.

Interaction with drugs of other pharmacological groups

To date, no significant interactions of the drug with drugs of other pharmacological groups have been established.

Special instructions

The use of the drug can be combined with the use of other forms of Actovegin.

Terms and conditions of storage

The drug must be stored at a temperature of eighteen to twenty-five degrees Celsius. Its shelf life is three years. After the package is opened, the eye gel can be used for no more than four weeks.

Actovegin eye gel 20% is a drug that stimulates the regeneration of eyeball tissue. Ophthalmologists at the Yusupov Hospital prescribe the drug after a complete examination of the patient. Doctors take into account the presence of indications, contraindications, possible side effects and the ratio of benefit to risk of complications.

The main active ingredient of Actovegin 20% eye gel is purified calf blood extract. This natural preparation, which has high profile security. When applying Actovegin gel to eyeball medical staff strictly follows the instructions.

Release form and pharmacological action

Actovegin 20% eye gel is available in 5 gram tubes, which are packaged in cardboard packs. Instructions for use are included. Actovegin eye gel is a transparent, homogeneous mass, slightly yellowish or colorless. The drug contains 8 mg active substance– calf blood extract purified from proteins. Auxiliary components include:

• Carboxymethylcellulose;
• Sorbitol;
• Lactic acid;
• Thiomersal.

Actovegin activates metabolic processes in the tissues of the eyeball, improves nutrition and stimulates regeneration processes. In ophthalmology it is used topically. "Actovegin" activates cell metabolism by increasing the transport and further accumulation of glucose and oxygen, enhancing intracellular utilization. It increases the energy resources of the cell in conditions of insufficient oxygen supply due to impaired blood supply to the eye.

Indications for use of Actovegin eye gel

20% eye gel "Actovegin" is used in ophthalmology if available next indications:

• Corneal ulcers of various origins;
• Burns of the cornea with acid, alkali, lime;
• Radiation injuries corneas;
• Corneal epithelial defects in patients who use contact lenses.

The drug is used to prevent lesions during the selection of contact lenses in patients with atrophic and dystrophic processes in the cornea.

Directions for use, side effects, contraindications

The drug is intended exclusively for topical use. 1-2 drops of gel are squeezed out of the tube into the affected eye. The procedure is performed 1-3 times a day. The frequency of use is from one to three times a day. The duration of treatment is determined by the indications.

During treatment with eye gel, wearing soft contact lenses is not recommended. When using contact lenses, they should be removed before using the gel and not installed earlier than 15 minutes after instillation of the drug. Before performing the procedure, the nurse thoroughly washes her hands with soap and treats antiseptic solution and puts on sterile gloves. The patient sits comfortably in a chair and tilts his head back.

Having opened the tube, the nurse opens it with one hand palpebral fissure, the second one instills 2-3 drops of the contents of the tube. When using the gel, do not touch the tip of the tube to your eye. The tube must be closed after each use.

When using Actovegin eye gel, problems rarely occur. allergic reactions. Patients may experience itching, pain, lacrimation, burning of the conjunctiva, and scleral injection.

In this case, ophthalmologists discontinue the drug and carry out antiallergic therapy. Actovegin 20% eye gel is not prescribed for individual hypersensitivity back to main active substance or auxiliary components of the drug. The question of the feasibility and safety of using Actovegin eye gel during pregnancy is decided by ophthalmologists individually.

Actovegin eye gel is compatible with other medicines, which are used locally in the treatment of the organ of vision. At complex treatment nurses apply the drug to the eyeball 30 minutes after instillation of another drug. Tubes with 20% Actovegin eye gel are stored in the refrigerator. The shelf life of the drug is 3 years. Dispensed with a doctor's prescription.

Get advice from an ophthalmologist by making an appointment.

References

• ICD-10 ( International classification diseases)
• Yusupov Hospital
• The British Journal of Ophthalmology, August 1923. British masters of ophthalmology series - George Critchett
• Astakhov Yu.S., Tultseva S.M., Umnikova T.S. Modern methods of treating retinal vein thrombosis // Congress of Ophthalmologists of Russia, 8th. – M.: 2005. – 372 p.
• Gavrilova N.A. Pathogenetic mechanisms of development of diabetic retinopathy, diagnosis early stages, prognosis and prevention of development, differentiated approach to treatment: Abstract of thesis. dis…. Doctor of Medical Sciences – M., 2004. – 47 p.

Prices for services *

Service	Price
Primary appointment (examination, consultation) with an ophthalmologist	Price: 3,600 rubles
Repeated appointment (examination, consultation) with an ophthalmologist	Price: 2,900 rubles
Selection of glasses	Price: 1,960 rubles
Biomicroscopy of the eye	Price: 2,580 rubles
Gonioscopy	Price: 1,600 rubles
Computer perimetry	Price: 2,580 rubles
Examination of the periphery of the fundus with a three-mirror Goldmann lens	Price: 1,550 rubles
Measuring the strabismus angle	Price: 1,140 rubles
Scotometry (Amsler-Marinchev test)	Price: 1,240 rubles
Exophthalmometry	Price: 1,140 rubles
OPHTHALMOLOGICAL CHECKUP	Price: 8,750 rubles

*The information on the site is for informational purposes only. All materials and prices posted on the site are not public offer, determined by the provisions of Art. 437 Civil Code of the Russian Federation. For accurate information, please contact the clinic staff or visit our clinic. List of services provided paid services indicated in the price list of the Yusupov Hospital.