Reviews of dicynon during menstruation and how to take the drug. Dicinon tablets: what are they for, how to use, what are the contraindications, instructions for Dicinon tablet

Dicynone tablets– instructions for use – take orally, during or after meals, with water.
Dicinone injection solution in ampoules (injections)– instructions for use

1. Administer intravenously, slowly.
2. Administer intramuscularly, before heating the solution to a temperature of 30-35 °C.
3. Locally – apply a napkin moistened with the solution to the area of ​​capillary bleeding.

Dicinon instructions for use for menstrual and uterine bleeding

During menstruation, Dicinon is prescribed:

1. In tablets - in order to reduce intense discharge, 1-2 tablets 2-3 times a day.
2. In solution for injection - for severe bleeding, starting dose is 1-2 ampoules, followed by injections of 1-2 ampoules every 4-6 hours.

1. To prevent chronic hemorrhage - 2 tablets 3 times a day. The course should begin 5 days before the end of the menstrual cycle, duration – 10 days.
2. For the treatment of acute uterine bleeding - intramuscularly or intravenously, an introductory dose of 2 ampoules, then 1-2 ampoules every 4-6 hours until the bleeding is eliminated.

Dicinone during pregnancy - instructions for use

During early pregnancy, Dicynon is prescribed if there is no danger to the embryo, only in tablets. In the 2nd and third trimesters it is used:

1. To eliminate minor bleeding.
2. When elements of the placenta are detached.
3. To combat nasal hemorrhages.

Dicynone dosage

The dose of the drug depends on the pathology and indications

1. Treatment of chronic hemorrhages – 1-2 tablets 2-3 times a day.
2. Before surgery - 1-2 tablets (0.25 - 0.5 g), or 1-2 ampoules an hour before the start. In case of severe blood loss, repeated administration is possible.
3. Treatment of acute hemorrhages – 3-4 ampoules or 3-4 tablets 2-3 times a day.
4. For the destruction of retinal vessels in diabetes - 1-2 tablets 3 times a day.
5. For children, the dose is halved.

Composition and release form

Dicynone Tablets

1. Active ingredient – ​​ethamsylate, 0.25 g.
2. Additional substances - anhydrous citric acid, starch, povidone K25, magnesium stearate, milk sugar.

Dicynone Solution for injection

1. Active ingredient: ethamsylate 0.125 g per ml, 0.25 g per ampoule.
2. Additional substances – water for injection, sodium disulfite, sodium bicarbonate.

Packaging and price

Pills– 10 white tablets in a paper blister, 10 blisters per package. Price – 32 UAH / 87 RUR. for 10 tablets.
Solution for injection– transparent glass ampoules, 2 ml each, 10 pieces per blister, 5 blisters per package. Price – 35 UAH / 94 rubles. for 10 ampoules.

Vitamin K preparations

Pharmacological properties

Etamsylate is a powerful hemostatic agent, improving the contact between endothelium and platelets. It reduces capillary permeability and the synthesis of substances that destroy blood clots and dilate blood vessels. As a result, platelets adhere better to the vascular wall at the site of disruption, significantly reducing blood loss.

Digestibility

After administration, the tablets are completely absorbed in the small intestine. The maximum level of the active substance in the blood is observed after 3.5-4 hours. Over 90% of the drug is bound to plasma proteins.

When administered parenterally, the pharmacological effect appears within 5-30 minutes, depending on the route of administration. The maximum level in the blood is observed after 40-60 minutes. 85-90% of the drug is bound to plasma proteins.

Etamsylate enters the bloodstream of the fetus; there is no data on its excretion in milk. The half-life in the blood is 1.5-2 hours. One day after use, 75% of the drug is excreted in the urine in its pure form.

Overdose

There are no known cases of overdose with Dicinone.

Dicynon indications for use

Taking Dicinon is indicated in the following cases:
• Prevention and treatment of bleeding during surgical interventions.
• Fighting bleeding from small vessels in diseases of the kidneys, uterus, damage to the nose, and pathological menstruation.
• To prevent perivintrocular bleeding in premature infants.
• For diabetes-related hemorrhages in the structures of the eye.

Dicinone contraindications

Taking Dicinon is contraindicated for:
• Individual intolerance to the components of the drug.
• Severe porphyria.
• Reduced blood clotting time.
• Tendency to form blood clots.
• Osteosarcoma.

Dicynone side effects

Taking Dicinon can cause the following side effects:
Nervous system
• Migraine.
• Disorders of the vestibular apparatus.
• Hypersensitivity of the skin of the feet.
Digestive system
• Vomit.
• Unpleasant sensations in the stomach area.
• Heartburn.
Other systems
• Skin rash.
• Drop in blood pressure.
• Facial redness.

Special instructions

1. Dicynone is ineffective if there is a lack of platelets in the blood.
2. If a weekly course of taking Dicinon does not reduce pathological discharge during menstruation, you should consult a doctor for re-diagnosis.
3. Use caution when used in patients with unstable blood pressure.
4. It is forbidden to use Dicynon if the solution is reddish in color.
5. In the absence of symptoms, side effects do not affect the reaction rate.

Interaction

1. Do not mix in the same container with other medications, with the exception of solutions for intravenous administration.
2. When used simultaneously with aminocaproic acid, the hemostatic effect of Dicinone is enhanced.
3. Concomitant use with Tranxam is prohibited.
4. Dicynone may reduce the biological effectiveness of thiamine.
5. After adding the drug to an isotonic salt solution, it must be used up immediately.
6. Dicynone and alcohol are incompatible - simultaneous use increases the risk of blood clots.

Terms of sale

Prescription sales.

Storage conditions and shelf life

Store in a dark place at a temperature of 15-25 ° C. Shelf life 3 years from the date of production.

Dicinon reviews for menstruation and bleeding

The majority of women surveyed noted the high effectiveness of Dicinon for combating heavy flows during menstruation and uterine bleeding. Side effects were rare and manifested mainly as skin rash.

Doctors note the powerful hemostatic effect of Dicinon in the prevention and treatment of post-traumatic and post-operative bleeding. Occasionally there is a short drop in blood pressure due to intravenous use.

Kalorizator 2020 - Vitamins, instructions for medications, proper nutrition. All information is for informational purposes only. Be sure to consult a doctor during treatment.

The action of the drug is based on the ability of ethamsylate to create thromboplastin. Dicinone in ampoules is used, according to the instructions for use, for bleeding and hemorrhage.

This is what genuine dicinone looks like in ampoules. Instructions for use must be included in the package

In addition to the main ingredient, the medication contains water, sodium disulfite and bicarbonate. The solution is colorless and transparent.

The drug promotes the formation of mucopolysaccharides, which protect protein fibers from damage and normalize capillary permeability. Dicynone removes excess fluid located in the bloodstream of the vessel, increases the strength of capillaries, provokes the creation of platelets in the hematopoietic bone marrow, prolongs their existence and enhances activity.

The advantage of Dicinon is that it does not constrict blood vessels, does not increase coagulation and does not provoke the formation of blood clots.

After 15 minutes after injection into the vein, the effect of the medicine appears. The peak effect is noticeable an hour after the injection. The total duration of action lasts no more than 6 hours.

In a situation where the medication is injected into the muscle, the effect becomes noticeable four hours after the injection.

Dicinone is perfectly absorbed in the body and is equally distributed throughout the organs and tissues. Practically does not react with proteins and enzymes contained in the blood. The medication is quickly eliminated from the body with urine and bile.

Indications for use of the drug Dicynon in ampoules

The medication is used for the prevention and treatment of cerebral hemorrhages during stroke, trauma, capillary bleeding, as well as in:

• gynecology;
• obstetrics;
• dentistry;
• urology;
• ophthalmology;
• otorhinolaryngology.

The medication is prescribed for damage to internal organs and hemorrhages in them: spleen, kidneys or liver; for bleeding caused by qualitative inferiority of platelets or a decrease in the number of formed elements in the blood; with slow blood clotting; with microangiopathy caused by diabetes; with hemorrhagic diathesis or vasculitis.

Dicinone in ampoules is used, according to the instructions and recommendations of doctors, in urology and gynecology for uterine dysfunction, menorrhagia, in women with intrauterine devices, metrorrhagia, endometriosis, hematuria, stopping bleeding after abortions and for hemorrhages inside the skull in newborns.

In dentistry, the medication is used for severe bleeding gums and during dental procedures and operations. In otorhinolaryngology - with epistaxis. In ophthalmology, the medicine is used to prevent hemophthalmos and secondary hemorrhages in the retina, as well as to reduce blood loss during ophthalmic surgical interventions.

Dicynone is also used for bleeding caused by Vergolf's disease.

Dicinone acts as an angioprotector for varicose syndromes, hepatitis, liver cirrhosis, radiation and chemotherapy, retinopathy, atherosclerosis, nephritis, angiopathy, toxic effects on blood vessels during viral and microbial infections.

Who should not use Dicinon: contraindications

Injections are effective if you use the drug Dicynon in ampoules. But the instructions for use prohibit the use of the medication if there is a history of:

• asthma;
• vascular thrombosis;
• thromboembolism;
• acute form of porphyria;
• intolerance or hypersensitivity to any components of the drug;
• tumors (both in children and adults).

Dicynone cannot be used for leukemia, osteogenic sarcoma and glucose-lactose deficiency.

Use of Dicinon during pregnancy and lactation

You should avoid injections during pregnancy. Use may only be prescribed if the intended benefit to the mother outweighs the risks to the embryo.

During pregnancy, the medication is used to combat brown and spotting discharge, detachment of the placenta and the outer membrane of the embryo.

In a situation where the use of the medication is prescribed during breastfeeding, the administration of Dicynon is possible, but subject to cessation of lactation. This is due to the fact that the drug substance, passing through all barriers, enters breast milk, and with it into the baby’s body.

How to use Dicinon

Injections of the drug are made into a muscle or vein (only in medical institutions), also into the space surrounding the eyeball and behind the eyeball.

The solution is also applied locally - a sterile cotton swab or napkin soaked in Dicynone is applied to the wound or into the oral cavity (for dental procedures).

Instructions for use for adults

Adults are administered no more than 20 mg of the drug per 1 kg of body weight. This dose is divided into 4 times, injections are carried out intravenously or intramuscularly. On the recommendation of a specialist, the dosage can be increased to 750 mg of medication per day.

Instructions for use for children

Children are prescribed Dicynon in ampoules with caution. Instructions for use for children suggest administration of no more than 10 mg (total) per unit of mass. There should be 4 injections in one day.

But usually the dosage for a child is calculated individually by the doctor.

For intracranial bleeding in newborn infants, drug therapy should begin no later than 2 hours after birth. Injections are given every 6 hours for four days.

Instructions for use for uterine bleeding

To prevent bleeding from the uterus, 250 mg of medication is injected into the body every 7 hours. The entire therapy lasts no more than ten days.

Dicinone helps fight abnormal bleeding, irregular menstruation, very heavy discharge and metrorrhagia.

Exceeding the dosage for gynecological diseases provokes the cessation of menstruation and disruption of the entire menstrual cycle. The question of prescribing the drug for strong or prolonged discharge is decided exclusively by the doctor. Using the drug, you can delay the onset of menstrual flow for no more than 2 weeks.

But in this case, it is necessary to be careful when prescribing the drug, because after drug therapy, the entire cycle may shift or there is a risk of hormonal disorders.

When using a medication to stop uterine bleeding, it is more than possible that some side effects may occur. For example, heartburn, dizziness, numbness of the limbs and others.

To consolidate the achieved effect, you need to take a second course of Dicinon before the next menstruation.

Instructions for use in surgery

In surgery, the drug is used to prevent bleeding in the intestines, lungs and other internal organs; when removing tumor tumors.

To reduce blood loss during surgical interventions, Dicynon is administered in ampoules. Instructions for use in surgery suggest administration of the drug 60 minutes before surgery in the amount of two ampoules (500 mg). Then repeated injections can be carried out during the operation and after its completion every 5 hours to stop bleeding and to prevent postoperative bleeding.

It is necessary to pay attention to the fact that Dicinone, mixed with a solution of sodium chloride, must be introduced into the body immediately.

Dicinone in ampoules: side effects and complications

Before starting therapy with Dicynon, you should pay attention to the fact that the medication can cause side effects. Often, rashes and hyperemia may appear on the skin, and headaches and dizziness may appear on the nervous system. Problems with the digestive system may occur:

• heartburn;
• nausea;
• vomit;
• heaviness;
• pain syndromes.

In addition, Dicynon has a serious effect on the cardiovascular, lymphatic and circulatory systems. The effect is manifested in a decrease in blood pressure, the occurrence of thromboembolism, thrombocytopenia, neutropenia, and agranulocytosis.

Effects on the immune system are very rare. But it can manifest itself in the form of allergic reactions, itching, swelling and redness.

Side effects may include fever and asthenia. Also, sometimes redness and itching appear at the injection site.

Special instructions for the use of the drug Dicinon

Dicynon solution in ampoules is intended for use only in clinics and other medical institutions.

The use of the drug is possible in individual doses, calculated for the patient personally by the doctor.

Caution should be exercised when prescribing the drug to patients who have suffered thrombosis and bleeding caused by taking anticoagulants. You should stop using the medication if you are intolerant or excessively sensitive to etamsylate.

If hemorrhagic complications are observed due to anticoagulant therapy, then antidotes must be used.

The drug can be taken prophylactically. For these purposes, it is either injected into a vein or taken orally.

Dicinone is not compatible with other medications in the same container, but it can be prescribed together with other medications of different action groups.

The drug must be stored in a dark, cool place with an air temperature of no more than 25°C.

The instructions for use state that the total period of use of Dicinone in ampoules should not be more than ten days. For diseases of the circulatory system and lesions of the blood vessels, the course of use of the drug should be no more than 2 weeks.

If there is a need to carry out Dicinon therapy for longer than the recommended period, then the total dosage should be gradually reduced.

Currently, medicine has made great strides forward. Medicines have been created that stop even severe bleeding, for example, Dicynon in ampoules. By using the drug according to the instructions, you can only bring benefits to the body.

Videos: Dicyonon what it is and how to use it

Dicynon in ampoules. Instructions for use, reviews, indications:

What is dicynon:

Dosage form:  pills Compound:

1 tablet contains:

active substance: etamsylate 250.0 mg;

excipients: anhydrous citric acid 12.5 mg, corn starch 65.0 mg, povidone K25 10.0 mg, magnesium stearate 2.0 mg, lactose 60.5 mg.

Description: Round, biconvex tablets, white or almost white. Pharmacotherapeutic group:hemostatic agent ATX:  

B.02.B.X.01 Etamsylate

Pharmacodynamics:

Etamsylate is a hemostatic, antihemorrhagic and angioprotective agent, normalizes the permeability of the vascular wall, improves microcirculation. Stimulates the formation of platelets and their release from the bone marrow. Increases platelet adhesion, stabilizes capillary walls, thus reducing their permeability, inhibits the synthesis of prostaglandins, causing platelet disaggregation, vasodilation and increased capillary permeability, which reduces bleeding time and reduces blood loss. Increases the rate of formation of the primary thrombus and enhances its retraction, has virtually no effect on the concentration of fibrinogen in the blood plasma and prothrombin time. With repeated use, thrombus formation increases.

Etamsylate has virtually no effect on the composition of peripheral blood, its proteins and lipoproteins. The erythrocyte sedimentation rate may decrease slightly.

Reduces fluid leakage and diapedesis of blood cells from the vascular bed, improves microcirculation. Does not have a vasoconstrictor effect.

Possessing antihyaluronidase activity and stabilizing ascorbic acid, it prevents the destruction and promotes the formation of mucopolysaccharides with high molecular weight in the capillary wall, increases the resistance of capillaries, reduces their “fragility,” and normalizes permeability in pathological processes. This angioprotective effect is manifested in the treatment of various diseases associated with primary and secondary disorders of the microcirculation process. Pharmacokinetics:

After oral administration, the drug is quickly and almost completely absorbed. The maximum plasma concentration after use of 500 mg is reached after 4 hours and is 15 mcg/ml.

Almost completely penetrates the placental barrier. It is unknown whether it passes into breast milk. About 95% of ethamsylate is bound to plasma proteins.

Etamsylate is slightly metabolized.

The half-life after oral administration is approximately 3.7 hours. About 72% of the drug is excreted unchanged by the kidneys within 24 hours.

Clinical studies on the use of ethamsylate in patients with impaired liver and/or kidney function have not been conducted.

Indications:

Prevention and treatment of capillary bleeding of various etiologies:

Before and after surgical interventions on all well-vascularized tissues in dental, otorhinolaryngological, gynecological, obstetric, urological, ophthalmological practice, plastic and reconstructive surgery;

Hematuria, metrorrhagia, primary menorrhagia, menorrhagia in women with intrauterine contraceptives (in the absence of organic pathology), nosebleeds, bleeding gums, vomiting blood, melena.

Contraindications:

Hypersensitivity to the components of the drug;

Acute porphyria;

Hemoblastosis in children (lymphoblastic and myeloblastic leukemia, osteosarcoma);

Thromboembolism, thrombosis;

Rare hereditary forms of lactose intolerance, lactase deficiency or glucose/galactose malabsorption (because the composition contains lactose);

Children under 3 years of age (for this dosage form).

With caution:

History of thrombosis, thromboembolism;

Bleeding due to an overdose of anticoagulants;

Impaired liver and kidney function (no clinical experience with use).

Pregnancy and lactation:

There are no clinical data regarding the possibility of using Dicinon in pregnant women. The use of Dicynon during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

There are no data regarding the excretion of ethamsylate into breast milk. Therefore, when using the drug during lactation, the issue of stopping breastfeeding should be decided.

Directions for use and dosage:

Inside.

The optimal daily dose of ethamsylate for adults is10-20 mg/kg body weight per day, divided into 3-4 doses. In most cases, a single dose is 250-500 mg (1-2 tablets); if necessary, a single dose can be increased to 750 mg (3 tablets).

Adults and teenagers(over 12 years old, weighing more than 40 kg)

In the preoperative period250-500 mg (1-2 tablets) 1 hour before surgery.

In the postoperative period 250-500 mg (1-2 tablets) every 4-6 hours until the risk of bleeding disappears.

To stop bleeding 500 mg (2 tablets) every 8-12 hours (1000-1500 mg per day) with food or a small amount of water.

In the treatment of metro- and menorrhagia 500 mg (2 tablets) 3 times a day (1500 mg per day) for 5-10 days.

Children from 3 to 12 years old

Half dose for adults.

Side effects:

According to the World Health Organization (WHO), adverse effects are classified according to their frequency of development as follows: often (>1/100,<1/10), нечасто (>1/1000, <1/100), редко (>1/10000, <1/1000) и очень редко (<1/10000), включая отдельные сообщения.

From the digestive system

often: nausea, diarrhea, discomfort in the epigastric region.

From the skin and subcutaneous tissues

often: skin rash;

frequency unknown: facial skin hyperemia.

From the nervous system

often: headache;

frequency unknown: dizziness, paresthesia of the lower extremities.

From the cardiovascular system

very rarely: thromboembolism;

frequency unknown: pronounced decrease in blood pressure.

From the blood and lymphatic system

very rarely: agranulocytosis, neutropenia, thrombocytopenia.

From the musculoskeletal system

rarely: arthralgia.

From the immune system

very rarely: allergic reactions.

Others

often: asthenia; very rarely: fever.

Side effects that occur during treatment are usually reversible when the drug is discontinued.

If skin reactions or fever develop, discontinue therapy and inform your doctor, as this may be a manifestation of a hypersensitivity reaction.

Overdose:

To date, no cases of overdose have been described.

If an overdose occurs, symptomatic therapy must be started.

Interaction:

There is still no data on the interaction of etamsylate with other drugs.

A combination with aminocaproic acid and menadione sodium bisulfite is possible.

Special instructions:

Before starting treatment, other causes of bleeding should be excluded.

The drug is not effective in patients with thrombocytopenia.

For hemorrhagic complications associated with overdose anticoagulants, it is recommended to use specific antidotes. The use of the drug Dicinon in patients with impaired blood coagulation system parameters is possible, but it must be supplemented by the administration of drugs that eliminate the identified deficiency or defect of blood coagulation factors.

In this article you can read the instructions for use of the drug Dicynone. Feedback from site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Dicynon in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Dicynone in the presence of existing structural analogues. Use for the treatment and prevention of bleeding during operations, menstruation, miscarriages in adults, children, as well as during pregnancy and lactation.

Dicynone- hemostatic drug. The drug increases the formation of high molecular weight mucopolysaccharides in the walls of capillaries and increases the stability of capillaries, normalizes their permeability during pathological processes, and improves microcirculation. It has a hemostatic effect, which is due to the activation of thromboplastin formation at the site of damage to small vessels. The drug stimulates the formation of blood coagulation factor 3 and normalizes platelet adhesion. The drug does not affect prothrombin time, does not have hypercoagulable properties and does not contribute to the formation of blood clots.

After intravenous administration, the drug begins to act within 5-15 minutes; the maximum effect is observed after 1 hour, the duration of action is 4-6 hours.

Pharmacokinetics

After oral administration, the drug is quickly and almost completely absorbed. Etamsylate (the active ingredient of the drug Dicynon) penetrates the placental barrier and is excreted in breast milk. About 72% of the administered dose is excreted unchanged by the kidneys during the first 24 hours.

Indications

Prevention and treatment of capillary bleeding of various etiologies:

• during and after surgical operations on all well-vascularized tissues in otorhinolaryngology, gynecology, obstetrics, urology, dentistry, ophthalmology and plastic surgery;
• hematuria, metrorrhagia, primary menorrhagia, menorrhagia in women with intrauterine contraceptives, nosebleeds, bleeding gums;
• diabetic microangiopathy (hemorrhagic diabetic retinopathy, repeated retinal hemorrhages, hemophthalmos);
• intracranial hemorrhages in newborns and premature infants.

Release forms

Tablets 250 mg.

Solution for intravenous and intramuscular administration (injections in injection ampoules) 125 mg/ml.

Instructions for use and dosage

Pills

The optimal daily dose for adults is 10-20 mg/kg body weight, divided into 3-4 doses. In most cases, a single dose is 250-500 mg 3-4 times a day. In exceptional cases, the single dose can be increased to 750 mg 3-4 times a day.

For menorrhagia, 750-1000 mg per day is prescribed, starting from the 5th day of the expected menstruation until the 5th day of the next menstrual cycle.

In the postoperative period, the drug is prescribed in a single dose of 250-500 mg every 6 hours until the risk of bleeding disappears.

Children are prescribed a daily dose of 10-15 mg/kg in 3-4 doses.

Ampoules

The optimal daily dose for adults is 10-20 mg/kg, divided into 3-4 intramuscular or intravenous (slow) injections.

For adults undergoing surgical interventions, a prophylactic dose of 250-500 mg is administered intravenously or intramuscularly 1 hour before surgery. During surgery, 250-500 mg is administered intravenously; this dose can be repeated again. After surgery, 250-500 mg is administered every 6 hours until the risk of bleeding disappears.

For children, the daily dose is 10-15 mg/kg body weight, divided into 3-4 administrations.

In neonatology: Dicinone is administered intramuscularly or intravenously (slowly) at a dose of 12.5 mg/kg (0.1 ml = 12.5 mg). Treatment should begin within the first 2 hours after birth.

If Dicynon is mixed with saline, it should be administered immediately.

Side effect

• headache;
• dizziness;
• paresthesia of the lower extremities;
• nausea;
• heartburn;
• heaviness in the epigastric region;
• allergic reactions;
• facial skin hyperemia;
• decrease in systolic blood pressure.

Contraindications

• acute porphyria;
• hemoblastosis in children (lymphoblastic and myeloblastic leukemia, osteosarcoma);
• thrombosis;
• thromboembolism;
• hypersensitivity to the components of the drug and sodium sulfite;
• hypersensitivity to sodium sulfite (solution for intravenous and intramuscular administration).

Use during pregnancy and breastfeeding

Use during pregnancy is possible only in cases where the potential benefit of therapy for the mother outweighs the possible risk to the fetus.

If it is necessary to prescribe the drug during lactation, the issue of stopping breastfeeding should be decided.

Special instructions

Before starting treatment, other causes of bleeding should be excluded.

1 tablet of Dicynon contains 60.5 mg of lactose (the maximum daily dose of lactose should not exceed 5 g). The drug should not be prescribed to patients with congenital glucose intolerance, lapp lactase deficiency (lactase deficiency in some peoples of the North) or glucose-galactose malabsorption syndrome.

If the solution for intramuscular and intravenous administration becomes stained, it should not be used.

The solution for intramuscular and intravenous administration is intended only for use in hospitals and clinics.

The solution for IM and IV injections can be used topically: a sterile swab or gauze pad is soaked in the solution and applied to the wound (for example, skin graft, tooth extraction).

Impact on the ability to drive vehicles and operate machinery

No special precautions required.

Drug interactions

Administration of a dose of 10 mg/kg body weight 1 hour before the administration of dextrans prevents their antiplatelet effect. Administration of Dicynone after administration of dextrans does not have a hemostatic effect.

A combination with aminocaproic acid and menadione sodium bisulfite is possible.

Pharmaceutical interactions

Pharmaceutically incompatible (in one syringe) with other drugs.

Incompatible with sodium bicarbonate injection and sodium lactate solution.

Analogues of the drug Ditsinon

Structural analogues of the active substance:

• Etamsylate;
• Etamzilat-Verein;
• Etamzilat-Eskom;
• Etamzilate solution for injection 12.5%.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Dicinone is a homeostatic agent that prevents, reduces, and also stops bleeding.

Active ingredient

Etamsylate.

Release form and composition

Indications for use

It is used for secondary bleeding that occurs against the background of thrombocytopathy (qualitative inferiority of platelets), as well as thrombocytopenia (decreased number of platelets in the blood); with parenchymal (caused by damage to the lungs, spleen, kidneys and liver) and capillary (caused by damage to the smallest vessels) bleeding; with hematuria (blood in the urine); hypocoagulation (slow blood clotting) and intracranial hemorrhage.

Indicated for nosebleeds that occur due to high blood pressure; diabetic microangiopathy (damage to capillaries due to diabetes), hemorrhagic vasculitis (multiple microthrombosis and inflammation of the walls of microvessels) and hemorrhagic diathesis (tendency of the blood system to increased bleeding).

Used during menstruation to prevent heavy blood loss.

Contraindications

Contraindicated in cases of thrombosis, hypersensitivity to etamsylate, acute porphyria (increased levels of porphyrins in the blood), as well as thromboembolism, that is, blockage of a blood vessel by a blood clot.

It is prescribed with extreme caution for bleeding resulting from an overdose of drugs that reduce blood clotting.

Instructions for use Dicinon (method and dosage)

Pills

The daily dose of tablets for adults is 10-20 mg/kg body weight, divided into 3-4 doses. A single dose is 250-500 mg 3-4 times/day. In exceptional cases, the single dose can be increased to 750 mg 3-4 times a day.

• For menorrhagia, 750-1000 mg/day is prescribed, starting from the 5th day of the expected menstruation until the 5th day of the next menstrual cycle.
• In the postoperative period, the drug is prescribed in a single dose of 250-500 mg every 6 hours until the risk of bleeding disappears.
• Children are prescribed a daily dose of 10-15 mg/kg in 3-4 doses.

Solution

Dicynone solution for IM and IV injections: the daily dose for adults is 10-20 mg/kg, divided into 3-4 IM or IV (slow) injections.

• For adults undergoing surgical interventions, a prophylactic dose of 250-500 mg is administered intravenously or intramuscularly 1 hour before surgery. During surgery, 250-500 mg is administered intravenously; this dose can be repeated again. After surgery, 250-500 mg is administered every 6 hours until the risk of bleeding disappears.
• For children, the daily dose is 10-15 mg/kg body weight, divided into 3-4 administrations.

Side effects

The use of the drug Dicinon in some cases can cause the following side effects: heaviness in the epigastric region (upper abdominal wall), heartburn, overflow of blood vessels in the face, headache, dizziness, numbness in the legs, allergic reactions, decreased blood pressure.

Overdose

No information available.

Analogs

Analogs by ATX code: Etamzilat.

Do not decide to change the drug on your own; consult your doctor.

Pharmacological action

The use of the drug helps to increase the formation of a large mass of mucopolysaccharides, which protect protein fibers from damage in the walls of capillaries. In addition, the drug allows you to normalize capillary permeability, increase their stability, and also improve microcirculation.

It has no effect on increasing blood clotting, does not contribute to the formation of blood clots and provides vasoconstriction. The effect of the drug is observed after one to two hours after oral administration and after 5-15 minutes after injection. The duration of the therapeutic effect is on average 4-6 hours.

Special instructions

• Before starting treatment, it is necessary to exclude other causes of bleeding.
• Please note that 1 tablet of Dicynone contains 60.5 mg of lactose. Therefore, the drug should not be prescribed to patients with congenital glucose intolerance, lapp lactase deficiency or glucose-galactose malabsorption syndrome.
• Do not use the solution for intramuscular and intravenous administration if it is colored.
• The solution is used only in inpatient settings and in clinics. It is permissible to use only locally.
• Does not affect the ability to drive vehicles.

During pregnancy and breastfeeding

Used only if the benefit to the mother outweighs the potential risk to the fetus. It is recommended to stop breastfeeding while using the drug.

In childhood

Prescribed according to indications in a dosage adjusted to the patient’s age.

In old age

No information available.

Drug interactions

• Administration of a dose of 10 mg/kg body weight 1 hour before the administration of dextrans prevents their antiplatelet effect. Administration of Dicynone after administration of dextrans does not have a hemostatic effect.
• Can be combined with aminocaproic acid and menadione sodium bisulfite.
• Dicynone solution is pharmaceutically incompatible (in the same syringe) with other drugs.
• Incompatible with sodium bicarbonate injection and sodium lactate solution.