Tranexam use during pregnancy. How to take Tranexam at different stages of pregnancy? Doses for using the medicine in tablet form

There are many reasons that can cause uterine bleeding in women. The modern drug Tranexam is often used in treatment - an effective remedy that allows you to cope with new bleeding or heavy periods in the shortest possible time.

Description of the drug Tranexam

The drug Tranexam is often used to treat uterine bleeding. It is used in therapy to reduce and restore the volume of menstruation, to stop bleeding and reduce the risk of miscarriage against the background of bleeding.

The main active ingredient of this medicine is tranexamic acid. It is able to influence fibrinolysin, a substance contained in the blood that prevents it from clotting.

An increased content of fibrinolysin provokes intense and prolonged bleeding. This occurs when platelets are unable to sufficiently produce plasmin, a component that ensures normal blood clotting. Tranexam is able to convert fibrinolysin into plasmin, thereby helping to stop the increased secretion of bloody biological fluid.

Pharmacological effect of the drug on the human body:

• local and systemic hemostatic (hemostatic);
• anti-inflammatory;
• antihistamine (anti-allergic);
• anti-infective;
• antitumor;
• analgesic (pain reliever).

Release forms and composition of the drug

The drug has two forms of release: tablets and solution for intravenous administration.

The tableted product consists of convex white tablets covered with a water-soluble film. The solution is a clear liquid, colorless or with a slight light brown tint.

• active substance: tranexamic acid in the amount of 250 or 500 mg;
• auxiliary components:
  • core: cellulose, hyprolose, talc, silicon dioxide, sodium carboxymethyl starch and calcium stearate;
  • shell: titanium dioxide, talc, macrogol, hypromellose.

The composition of the solution for injection in an amount of 1 liter:

• tranexamic acid in a volume of 50 g;
• excipient - distilled water up to 1 liter.

Uterine bleeding, in the treatment of which Tranexam helps

Uterine bleeding can be caused by various conditions or pathologies. They are conventionally divided into 2 categories:

1. The result of systematic disorders in different organs or systems.
2. Dysfunctions associated with changes in the functioning of the reproductive organs.

There are many reasons for such uterine bleeding. Among them:

1. Extragenital (not related to diseases of the genitourinary system):
   1. Liver diseases such as cirrhosis and liver failure.
   2. Diseases of the cardiovascular system, such as atherosclerosis, hypertension.
   3. Infections:
      • flu;
      • measles;
      • sepsis;
      • typhoid fever.
   4. Functional decrease in thyroid function.
   5. Blood diseases:
      • hemophilia;
      • hemorrhagic vasculitis;
      • low levels of vitamins C and K in the body.
2. Causes associated with pregnancy due to genital diseases:
   1. Pregnancy occurring with disturbances in the early stages:
      • uterine;
      • ectopic.
   2. In the later stages:
      • scars on the uterus;
      • placental abruption;
      • destruction of cervical tissue;
      • placenta previa.
   3. Generic reasons:
      • cervical ruptures;
      • delayed separation of placenta;
      • injuries of the birth canal and genital organs;
      • low location of the placenta;
      • placenta defects.
   4. Postpartum pathologies:
      • weak uterine tone;
      • delayed release of placenta;
      • endometriosis.
3. Genital disorders not related to pregnancy:
   1. Bleeding in different age periods associated with pathologies in the functions of the hypothalamic-pituitary-ovarian-adrenal system (depending on the presence or absence of ovulation, this is the so-called dysfunction):
      • juvenile, relating to the period of development of the genital organs and maturation (from 10 to 18 years);
        

        If uterine bleeding manifests itself before the age of 9–10 years, then this may be the consequences of the occurrence of “false” puberty of the child against the background of the development and growth of ovarian tumors.

      • reproductive (puberty);
      • menopausal, directly dependent on menopause (after 45 years).
   2. Tumors on the internal genital organs, including fibroids.
   3. Ruptures of the ovary or cysts on it.
   4. Uterine injuries.
   5. Inflammatory and infectious diseases of the reproductive organs:
      • cervical erosion;
      • endometritis;
      • vaginitis and vaginosis;
      • cervicitis;
      • endocervicosis.

Such bleeding can be caused by an additional number of factors:

• chronic illnesses;
• emotional and mental overexcitation;
• prolonged stress;
• physical overload;
• heredity;
• hypovitaminosis;
• mental trauma;
• endocrine diseases;
• complications after childbirth or abortion.

In addition to the above indications, the basis for prescribing Tranexam, at the discretion of the attending physician, may be allergic reactions, blood diseases and surgical interventions.

The risk of developing uterine bleeding is assessed by determining PCT in a blood test:

Uterine bleeding - video

Contraindications

There are a number of contraindications to the use of Tranexam:

• hypersensitivity to the components of the drug;
• subarachnoid hemorrhages (spontaneous effusions of blood into the cavity between the meninges, the result of a rupture or traumatic brain injury);
• thrombosis of various origins:
  • cerebral vessels;
  • myocardial infarction;
  • thrombophlebitis;
• color vision impairment;
• renal failure;
• hematuria of the urinary tract (high content of red blood cells in the urine);
• thrombohemorrhagic complications.

• penicillins;
• tetracyclines;
• drugs for the treatment of hypertension;
• other hemostatic agents (hemostatic drugs).

Use of Tranexam during pregnancy and lactation

Tranexam is widely used in gynecology as a remedy that can prevent the threat of miscarriage. It is prescribed by a doctor after a thorough examination of the pregnant woman, since in the presence of certain health problems, for example, in the case of thrombosis, the use of this drug is prohibited.

During lactation, the medication is taken exclusively for health reasons, since Tranexam carries a potential risk for the child. At the same time, it is recommended to stop breastfeeding for the duration of treatment and switch the baby to formula.

Possible side effects

When using Tranexam in tablets, especially if the prescribed dosage is violated, the following side effects may occur:

• nausea and vomiting;
• heartburn;
• unstable stool, possible diarrhea;
• skin itching;
• rashes on the body;
• weakness of the whole body (lethargy);
• dizziness;
• drowsiness;
• decreased appetite;
• color vision impairment;
• thrombus formation.

A solution for infusion (intravenous and intramuscular administration) can cause the following undesirable effects:

• allergies in the form of:
  • rashes;
  • hives;
  • skin itching;
• dyspeptic reactions (disruption of the normal function of the gastrointestinal tract, difficult and/or painful digestion):
  • anorexia;
  • diarrhea;
  • nausea;
• tachycardia;
• pain in the chest area;
• hypotension;
• blurred vision;
• dizziness.

Instructions for use of tablets and solution

Tranexam tablets are taken orally (by mouth) 3-4 times a day. Dosages and duration of treatment are determined by the doctor in accordance with the diagnosed disease. Usually the course duration is no more than two weeks. Therapy is carried out under the supervision of medical staff; independent use is prohibited.

The solution for infusion is administered dropwise or in a stream. The dose is calculated by a specialist. Sometimes a one-time use is enough. The maximum duration of treatment is three days.

Tranexam's analogs

There are structural and pharmacological analogues of this drug. Those medications that are based on the same active ingredient have similar effects and contraindications to Tranexam:

• Exacyl;
• Troxaminate;
• Traxara;
• Cyclocapron.

What can replace the medicine - table

Drug name	Release form	Active ingredient	Contraindications for use	Use during pregnancy	Average cost
Dicynone	solution for intravenous/intramuscular administration; pills.	ethamsylate	thrombosis; thromboembolism.	with caution in the 1st trimester	tablets 100 pcs. - 400 rubles; injections 5 ampoules - 200 rubles.
Ambien	solution for intravenous administration; powder-substance.	aminomethylbenzoic acid	thrombosis; renal dysfunction; pregnancy; blood clotting disorder; hypersensitivity to the components of the drug ischemia of the heart and brain.	forbidden	injections 5 ampoules - 2,000 rubles
Vikasol	pills; injection solution.	menadione sodium bisulfite	thromboembolism; violation of the outflow of bile; liver failure.	forbidden	tablets 20 pcs. - 15–25 rubles; injections in ampoules 10 pcs. - 80 rubles.
Vilate	substance for preparing a solution	blood clotting factor VIII; von Willebrand factor.	hypersensitivity to the components of the drug	allowed	packaging - 15,000 rubles
Methylergobrevin	solution for intravenous and intramuscular administration	methylergometrine maleate	hypertension; hypersensitivity to the components of the drug; sepsis; vascular diseases.	forbidden	5 ampoules - 250 rubles

Tranexam is most often used during pregnancy. Because the drug is aimed at eliminating the risk of miscarriage. Available in 2 forms - tablets and solution for drip or jet injection. During pregnancy, a tablet drug is most often prescribed, but another option is also possible.

Composition and properties

"Tranexam" refers to a fibrinolysin inhibitor, which prevents and stops bleeding. Thanks to tranexamic acid, silicon dioxide, microcrystalline cellulose and sodium glycolate, which is part of the drug, the following effect occurs:

1. The drug helps suppress kinins and some peptides, thereby eliminating allergic reactions and inflammatory processes. Therefore, Tranexam has anti-inflammatory, antiallergic, and antitumor properties.
2. The blood thickens and the process of non-coagulation accelerates, which is especially important during bleeding.
3. The uterine tone decreases, due to which there is a risk of miscarriage.
4. If the drug is taken for a long time, it has an analgesic effect, that is, a pain reliever.

"Tranexam" is prescribed to pregnant women in the following cases:

• bleeding:
• nagging pain in the lower abdomen;
• premature aging of the placenta;
• peeling of the fertilized egg;
• tendency to allergies;
• inflammatory processes;
• if you have previously had miscarriages;
• suspicion of miscarriage.

The drug is prescribed to prevent heavy bleeding after labor. And also with heavy or painful menstruation.

The effect of tranexamic acid on the body of a pregnant woman

The main active ingredient of the drug "Tranexam" is tranexamic acid. It is obtained from the amino acid lysine synthetically.

The peculiarity of the substance is that there is no metabolization, due to which the acid is completely eliminated from the body through the kidneys through urine. It does not penetrate the fetal placenta, therefore it is a completely safe product.

"Tranexam" is used in medicine not only during pregnancy, but also in other cases. For example, with any bleeding, heavy menstruation.

Quite often, with minor hemorrhages, a uterine hematoma forms. That is, a certain amount of blood accumulates in a certain area of ​​a given organ, which is subsequently transformed into a neoplasm. And this leads to serious consequences. Hematomas form when a woman has a blood fluid clotting disorder. "Tranexam" promotes the resorption of these hematomas, as the blood structure is restored.

Possible contraindications and side effects

In some cases there are adverse reactions:

• nausea and vomiting;
• heartburn and weakness;
• temporary deterioration in visual acuity;
• dizziness and rapid heartbeat;
• pain in the sternum;
• thrombosis;
• allergies - skin rashes accompanied by itching and burning.

Contraindications:

1. It is strictly forbidden to use the drug for varicose veins, thrombophlebitis and thrombosis.
2. Intolerance to one of the components of Tranexam.
3. Subarachnoid bleeding.
4. Pathological disorders of the functionality of the renal system.
5. Poor blood circulation in the brain.
6. Breastfeeding, as the active substances easily penetrate into milk.
7. Increased content of red blood cells in the urine, that is, hematuria.
8. The drug is not prescribed intravenously in cases where a blood transfusion was performed.
9. It is prohibited to use Tranexam together with drugs containing penicillin and tetracycline.
10. Tranexamic acid is incompatible with other hemostatic agents and drugs intended to lower blood pressure.

How and how much you can take Tranexam during pregnancy - dosage

Each human body has individual characteristics. Pregnancy also progresses differently. But the risk of miscarriage in the first trimester exists for almost every woman. There are many reasons for this. However, the drug "Tranexam" is considered universal, as it is used in all cases.

Most often the tablet form is prescribed. In this case, the tablets are taken three or four times a day, 1 or 2 units, depending on the purpose. You should take the tablets immediately after eating. The duration of treatment varies depending on the indication. So, a woman can use the drug for 1 week or several. There are no restrictions on the course of administration, since Tranexam is not addictive.

If the doctor prescribes an injection solution, then its dosage depends on the purpose of therapy:

1. In case of bleeding from the uterus and hematoma, the drug is administered by drip through a dropper 2-3 times a day, 1,000-1,500 mg.
2. If bleeding is detected in the first months of pregnancy, then the dosage is from 250 to 500 mg. The drug is administered four times a day.
3. If an allergic reaction or inflammatory processes are noted, then Tranexam is prescribed twice a day, 1,000-1,500 mg. It is enough to drip 2 times.
4. For generalized fibrinolysis, an IV is initially placed, and then a tablet form of the drug is prescribed.

The decision to prescribe the dosage of the drug "Tranexam" is made at the individual level. It depends on the course of the disease and pregnancy, the characteristics of the body, the level of blood loss, etc.

Application at various times

On first trimester tranexamic acid is prescribed in the following cases:

• inflammatory processes;
• tumor neoplasms;
• spotting and bleeding;
• threat of miscarriage;
• allergy to any allergen;
• pharyngitis;
• tonsillitis;
• hemophilia;
• leukemia;
• liver pathologies;
• angioedema;
• intoxication.

Second trimester:

• pain in the lower abdomen of a pulling and aching nature;
• spotting, blood loss;
• risk of losing a child.

Third trimester:

• stomach ache;
• threat of premature birth;
• bleeding and spotting.

What is better to take: Dicinon or Tranexam during pregnancy?

The drug "Ditsinon" refers to an analogue of the drug "Tranexam". However, they have a slight difference. Firstly, there is cost. For example, “Tranexam” (10 tablets) has a price of 230-260 rubles, and “Ditsinon” for the same amount is 40-50.

Secondly, the effectiveness of the second is significantly different from tranexamic acid, because Tranexam is such a strong drug that it is often used as a first aid remedy. That is, it can stop bleeding instantly.

Thirdly, the side effects of Dicynon are less pronounced. But both types of drugs are produced in tablet form and in injection form. It is up to the doctor to decide what to choose specifically for you.

Pros and cons of admission

Benefits and taking the drug "Tranexam":

• instant healing effect;
• safety for the mother and unborn child;
• relatively low cost of the drug;
• Possibility to use for a long time - no addiction;
• in some cases the duration of the course is only a few days;
• comprehensive effect on the body;
• can be bought at any pharmacy.

Flaws:

• it is necessary to strictly adhere to dosages;
• there are a number of contraindications;
• sometimes adverse reactions occur.

To summarize, it should be noted that Tranexam is a fairly effective and safe remedy that will help not only stop bleeding, but also get rid of many other problems. It has many analogues, but only a doctor should select it.

Termination of pregnancy (detachment of the ovum) is the most serious pathology that can occur during pregnancy. Most often this happens in the early stages, when a woman’s body produces insufficient progesterone.

Doctors believe that the main causes of this pathology are excessive nervous tension, chronic stress, poor diet, alcohol consumption and smoking.

The most dangerous period in terms of maintaining pregnancy is considered to be from 4 to 8-12 weeks. The first sign of the onset of abruption is bloody discharge, which can be insignificant (literally a few drops) and quite abundant, turning into uterine bleeding. To stop it, the woman is prescribed hemostatic drugs, one of which is Tranexam.

The main active ingredient is tranexamic acid. It has anti-inflammatory and hemostatic effects. With long-term use, a moderate analgesic effect is observed, so the drug helps not only stop bleeding, but also eliminate nagging pain in the lower abdomen and lower back.

This property of tranexamic acid allows the use of Tranexam for painful and heavy menstruation (menorrhagia) and for the prevention of heavy postpartum bleeding.

The drug is available in three dosage forms:

• white, convex film-coated tablets (250 mg and 500 mg);
• intravenous solution (50 g of tranexamic acid in 1 liter of the drug);
• injection solution.

In case of severe bleeding, Tranexam is used in the form of a solution. After the attack has stopped, the woman is prescribed further Tranexam in tablet form to maintain the therapeutic effect and prevent new bleeding.

Important! The active ingredient of the drug exhibits moderate antiallergic properties, so Tranexam can be included in combination therapy for women prone to allergies.

Can I take it during pregnancy?

Tranexam is considered a safe drug for use during pregnancy, but no formal studies have been conducted on this topic. Tests on animals did not reveal any negative effects on the fetus, but it was found that the active substance is able to penetrate the placental barrier and accumulate in the tissues and organs of the fetus.

Most often, the drug is prescribed to expectant mothers in the first trimester, since it is during this period that the risk of spontaneous abortion is highest. To avoid negative consequences, it is important to adhere to the following recommendations from experts:

• do not use Tranexam without a doctor’s prescription, since there is no reliable data on the effect of the drug’s components on the course of pregnancy and fetal development;
• Before use, consult an ophthalmologist (for women with impaired color vision and pathologies of the fundus, the use of the medicine is not recommended);
• If side effects occur or your health deteriorates during treatment, report this to the gynecologist managing the pregnancy or the specialist who made the prescription.

Important! Despite the lack of data on the safety of use during pregnancy, doctors prescribe Tranexam, considering it one of the most effective and efficient drugs.

Many years of experience in use confirms good tolerability and the absence of embryotoxic effects, so in most cases the drug becomes the drug of choice when there is a threat of miscarriage.

Tranexam for bleeding and other diseases

The main indication for the use of Tranexam during pregnancy is the appearance of spotting, bleeding, and hematomas. Severe bleeding is dangerous not only for the fetus, but also for the woman’s life, so in such cases, increased doses of tranexamic acid are prescribed, which are administered through a dropper.

The drug can also be prescribed for chronic diseases of the upper respiratory tract and oropharynx. The decrease in immunity that occurs during pregnancy can contribute to the exacerbation of chronic pathologies, therefore Tranexam is often included in the combination treatment of the following diseases:

• angina;
• tonsillitis;
• pharyngitis;
• laryngitis.

The use of the medicine is effective for stomatitis and ulcerative lesions of the oral mucosa. The product stops the inflammatory process and provides an analgesic effect, eliminating discomfort when eating.

"Tranexam" does not have antibacterial, antiviral or antifungal effects, therefore it can only be used as an adjuvant and does not replace the main treatment.

Another indication for the use of the drug during pregnancy is hereditary allergic reactions and diseases, for example:

• hives;
• rash of toxic origin;
• dermatitis;
• eczema;
• Quincke's edema.

Sometimes Tranexam is prescribed to prevent allergies when using potent drugs (if there is a need for their use).

Instructions for use and dosage: how much to drink

"Tranexam" is safe for expectant mothers, but only if the instructions are followed, so before use you need to familiarize yourself with the dosage and administration regimen.

Pills

The tablets are taken orally at any time of the day, regardless of meals. For bleeding, the dosage is calculated individually, taking into account the severity of the pathology and the severity of the main symptoms. The standard diagram looks like this:

• single dosage - 250-500 mg;
• amount of use per day - 3-4 times;
• Duration of treatment - 7 days.

For allergies and other diseases accompanied by inflammatory processes, the dosage is increased to 1000-1500 mg. The drug should be taken 2-3 times a day. The duration of treatment depends on the severity of symptoms and can range from 3 to 9 days.

Droppers and injections

A drip solution is prescribed for severe bleeding that cannot be stopped with oral forms of the drug. The dosage is usually from 10 to 15 mg per kilogram of a woman’s weight, but in some cases individual adjustment of the dosage regimen may be required.

The drug is infused by drop or stream method at a rate of 1 ml/min every 6-8 hours until bleeding stops completely. After the attack has stopped, the patient is prescribed further Tranexam in tablet form.

Contraindications and side effects

The only absolute contraindication to the use of Tranexam in expectant mothers is subarachnoid bleeding (bleeding into the space between the meninges). A limitation for use is also intolerance and hypersensitivity to the components of the drug.

As relative contraindications, the instructions indicate:

• myocardial infarction;
• formation of blood clots in the vessels of the brain;
• impaired visual acuity or fundus pathology;
• blood in the urinary tract;
• insufficiency of kidney function;
• thrombosis with inflammation of the venous walls (thrombophlebitis).

For the listed diseases, Tranexam should be taken with extreme caution and under constant medical supervision. Usually a woman is admitted to a maternity hospital hospital for safekeeping.

The drug is usually well tolerated, but in some cases, adverse reactions may occur, which include:

• headache;
• vomiting and nausea;
• decreased visual acuity;
• allergies (urticaria, eczema) - mainly when using the drug in solution form;
• heartburn;
• weakness and drowsiness;
• dizziness (in rare cases, loss of consciousness);
• pain behind the sternum and in the chest area;
• tachycardia.

Important! The use of Tranexam increases the likelihood of thrombosis and thromboembolism, but doctors believe that the risk of developing these pathologies is minimal. This information is confirmed by the official instructions.

What to replace: safe analogues

Replacing Tranexam for medical reasons is very rarely required, since the medicine is well tolerated and does not cause negative consequences for the course of pregnancy and fetal development.

If necessary, the drug can be replaced with drugs with a similar composition or similar pharmacological action. Tranexam analogues approved for pregnant women include:

• "Tranexamic acid";
• "Exacil";
• "Aerus";
• "Troxaminate";
• "Ingitril."

It is necessary to select an analogue together with the attending physician, since even with the same active ingredient, different adverse reactions may occur, which the doctor takes into account when prescribing treatment for a particular patient.

Tranexam is an effective drug that, when used correctly, rarely causes side effects and complications. It can be used during pregnancy only as prescribed by a doctor and after examination by an ophthalmologist, as vision deterioration and color perception may be impaired.

Almost half of women during pregnancy have to deal with such a serious complication as the threat of miscarriage. Such a threat can arise at any time, and if before the 28th week we are talking about a miscarriage, then over the next 10 weeks there is a threat of premature birth. To relieve the threat, Tranexam may be prescribed during pregnancy.

Pregnancy is a happy time for most women, but also very worrying. Various unfavorable factors can lead to spontaneous interruption. For treatment, a woman may be prescribed Tranexam intravenously or in tablet form. Let's figure out how effective this drug is and how the instructions recommend taking it.

When do risks increase?

Nowadays, the threat of spontaneous abortion is one of the most common problems that pregnant women have to face. About half of expectant mothers have to face this diagnosis.

The reasons for the threat of interruption may be different, these are:

• presence of chronic diseases;
• acute viral or bacterial infection;
• stress;
• high physical activity;
• bad environment, etc.

Advice! The threat of miscarriage especially often occurs in pregnant women aged 35+, so the age of the expectant mother can also be considered a provoking factor.

What to do if such a diagnosis is made? Don't panic! Modern medicine has great capabilities and, in most cases, pregnancy can be saved.

But you shouldn’t take your condition lightly. If you experience nagging pain in the lower abdomen or unusual discharge, you should urgently consult a gynecologist. And if there is bleeding, you should immediately call an ambulance.

Description

Forms

There are two versions of the drug on sale:

• solutions for intravenous administration;
• pills.

In any form, the main active ingredient is tranexamic acid. One tablet contains 500 mg of the active substance, one ampoule contains 250 mg.

When can it be appointed?

Using this medicine can stop bleeding and prevent miscarriage. Main indications for taking Tranexam:

• frequent or constant pain in the abdomen of a cramping or pulling nature;
• discharge mixed with blood;
• as a prophylaxis for patients who have experienced repeated miscarriages.

Advice! The instructions for the drug indicate that the drug is able to penetrate the placental barrier, but it cannot negatively affect the development of the fetus.

The drug can be used at any time. Moreover, in the early stages it is used most often, since at this time there is a greater risk of miscarriage.

Dosage

Of course, expectant mothers are interested to know how many days they will have to take the drug and what the dosage should be. The instructions for use offer different treatment regimens for various diseases. Standard schemes:

• for early bleeding, tablets can be prescribed; the instructions recommend drinking 1 tablet three or four times a day for 7 days. During this time, bleeding should stop;

Advice! If after 7 days of taking the discharge and nagging pain have not stopped, you should consult a doctor. He will decide how long he will need to continue taking the pills or decide whether to change the drug.

• for profuse uterine bleeding, you need to take 2-3 tablets four times a day for 3-4 days;
• in case of bleeding in a pregnant woman due to angiohemophilia, it is necessary to take 2-3 tablets four times a day for 5-10 days;
• for allergies and inflammatory processes, you need to drink 2-3 tablets two to three times a day for 3-10 days;

• for generalized fibrinolysis (breakdown of blood clots), at the first stage, intravenous droppers with Tranexam are prescribed every 6 hours, then you can switch to tablets;
• for local fibrinolysis, it is necessary to administer the drug intravenously twice a day;
• if there is a risk of bleeding, Tranexam can be prescribed intravenously. The doctor decides how much of the drug to administer; the dose is determined depending on the patient’s weight.

When is it prohibited to use?

The instructions for use provide a list of contraindications for the use of Tranexam, these are:

• individual intolerance;
• vein diseases (varicose veins);
• tendency to thrombosis;
• kidney dysfunction;
• disturbances in the blood supply to the brain.

It is prohibited to administer the drug intravenously if the patient has previously received a blood transfusion. But such patients can take pills. The drug should not be taken in combination with tetracycline antibiotics, as the combination of these drugs can cause the formation of blood clots.

Treatment with Tranexam during breastfeeding is not allowed, as the active substance passes into milk.

Side effects

Taking Tranexam rarely causes negative side reactions, however, they are not excluded. Possible appearance:

• nausea and heartburn;
• dizziness, weakness;
• tachycardia;
• skin allergic reactions.

So, Tranexam is most often prescribed during pregnancy to relieve the threat of miscarriage. The drug is safe for the fetus, so it can be used for treatment at any time, including in the first trimester. The doctor determines how long the treatment will last and what the dose of the drug should be depending on the patient’s health condition.

Currently, one of the most common diagnoses according to statistics is the threat of miscarriage. This conclusion is heard every day by hundreds of women who are carrying a child. Often for this reason, doctors prescribe Tranexam during pregnancy.

Drug instructions reviews
charging discomfort pulls
power in listening position

Fortunately, medicine has come a long way, and our doctors know how to combat this danger. Tranexam tablets are an excellent help.

Indications for prescribing the drug

As a rule, interruption occurs when the expectant mother begins to bleed. Tranexam during pregnancy makes the blood thicker and also enhances its clotting. Simply put, this drug stops bleeding and prevents miscarriage.

The drug is prescribed when bleeding occurs

Tranexam is prescribed for:

• the appearance of nagging pain in the lower abdomen;
• blood discharge from the vagina, and the sooner you start taking it, the better;
• previously diagnosed miscarriages or a diagnosis of “habitual miscarriage”, then the drug can be prescribed from the very beginning of pregnancy as a means of prevention;
• inflammatory processes;
• allergic reactions.

This drug freely penetrates the placenta, but does not have a negative effect on the fetus.

Moreover, tranexam is prescribed in the early stages of pregnancy, except in cases where a woman has problems with blood clotting that were observed even before conception.

Let's consider the most common reasons for prescribing this drug by trimester.

Trimester	Reason for appointment	Contraindications
First	inflammatory processes, tumors; stomatitis, pharyngitis, tonsillitis; allergic reactions caused by medications and toxins; bleeding – existing or possible with a high degree of probability; leukemia, hemophilia; hereditary angioedema; liver diseases.	Presence of subarachnoid bleeding. Kidney disorders. Thrombosis of blood vessels of the head. Deep vein thrombophlebitis.
Second	threat of miscarriage;
Third	threat of miscarriage; constant nagging pain in the lower abdomen and lower back.

Instructions for use of the medicine

According to the instructions for use, tranexam during pregnancy is a drug that reduces the fibrinolytic activity of the blood. It has a local and systemic hemostatic effect during bleeding caused by increased fibrinolysis (platelet pathology), as well as an anti-inflammatory, anti-allergic, anti-infective, anti-tumor effect due to the suppression of the development of kinins and other active peptides involved in allergic and inflammatory processes.

It is mandatory to read the instructions

Let's consider the dosage of tranexam during pregnancy.

Pills:

• tranexam for hematoma during pregnancy - 1000-1500 mg 2-3 times a day;
• profuse uterine bleeding - 1000-1500 mg 3-4 times a day, duration of administration - 3-4 days;
• bleeding due to von Willebrand disease - 1000-1500 mg 3-4 times a day, duration of therapy - 3-10 days;
• nosebleeds – 1000 mg 3 times a day;
• tranexam in the early stages to stop bleeding - 250-500 mg 3-4 times a day until bleeding stops completely; according to reviews, the course duration is about 7 days;
• hereditary angioedema – 1000-1500 mg 2-3 times a day;
• symptoms of allergic reactions, inflammatory processes - 1000-1500 mg 2-3 times a day;
• generalized fibrinolysis - a tranex drip is prescribed during pregnancy, followed by switching to tablets of 1000 mg 2-3 times a day.

Solution for injection:

• according to the instructions for tranexam during pregnancy with generalized fibrinolysis, 15 mg/kg is prescribed every 6 hours;
• local fibrinolysis - administration of the drug 250-500 mg 2 times a day;
• how to take the drug if there is an increased risk of bleeding - the doctor prescribes it individually, as a rule, the dose is 10-11 mg/kg.

As a rule, tranexam is well tolerated during pregnancy. The following side effects may sometimes occur:

• heartburn;
• nausea;
• vomit;
• general weakness;
• dizziness;
• visual impairment;
• rapid heartbeat;
• development of thrombosis;
• pain in the chest;
• allergic reactions: rash, itching, urticaria.

Contraindications.

1. Varicose veins.
2. Individual intolerance to the components of the drug.
3. Thrombosis.
4. Subarachnoid bleeding.
5. Kidney disorders.
6. Poor blood supply to the brain, even if it was observed before conception.
7. The drug should not be administered intravenously if the woman has had a transfusion of blood or its components.
8. Deep vein thrombophlebitis.
9. This drug should not be taken concomitantly with tetracyclines or diazepone. This can lead to active blood clot formation.
10. During breastfeeding, the drug poses a threat to the baby, because it is excreted in breast milk.

You need to listen to other women's reviews

Pros and cons of this tool

Let's consider the main advantages and disadvantages of the drug, according to reviews from women.

Women's opinion

Let's look at a few reviews from women who have experienced the effects of tranexam during pregnancy.

Margarita Tsvetaeva:

I planned my pregnancy for a long time, but it didn’t work out for a long time. She underwent a course of treatment from a doctor and became pregnant a year later. Happiness knew no bounds. However, I was not happy for long, because already in the 5th week strong nagging pains in the lower abdomen appeared, and the next day bloody discharge also appeared. I was very scared and immediately ran to the doctor. They examined me and said that there was a risk of miscarriage. First, the gynecologist prescribed Tranexam and told me how much to drink. If it doesn’t help, she promised to give me a referral to a hospital. I started taking it according to the prescription. Imagine my surprise when already on the second day all the symptoms disappeared. I calmed down, but finished the whole course to the end. I am very glad that you can take the drug during pregnancy, especially since the price of this drug is affordable.

Veronica Zagorelskaya:

I am familiar with this drug firsthand, since during my first pregnancy I took it for sudden bleeding. The effect was immediate, so when the gynecologist told me that to prevent a second pregnancy I needed to drink it for another week, I did not resist. She started taking it without hesitation, although there were no obvious indications for it. However, this time I began to feel very bad: a feeling of nausea appeared, I even vomited a couple of times in the morning, I wanted to sleep all the time. I was very worried and went to the gynecologist to check if everything was fine. The doctor examined me and said that this was a normal reaction of the body (adverse), nothing to worry about and I could continue the course. However, every day I felt worse and worse, so I did not finish the course. As soon as I stopped taking the pills, my condition improved, but nagging pain in the lower abdomen already appeared. A friend recommended another drug - diet, supposedly without such side effects. To be honest, I didn’t know what was better to take during pregnancy: dicynon or tranexam, but I didn’t experiment. I went to the doctor again. I was told to be sure to complete the course I started, otherwise there could be negative consequences. Through force, I finished the pills and forgot about all the negative aspects. But now my opinion about this drug is ambiguous.

Sabina Romanova:

At the 12th week of pregnancy, I was diagnosed with an inflammatory process, which was accompanied by bloody vaginal discharge. The gynecologist prescribed many different medications, including these pills. I got used to trusting my doctor, as she helped me overcome many diseases. That is why I did not even read the instructions for use, but immediately started taking it. Complex therapy helped me quickly cope with the disease. I don’t know what role this drug played, but the result is obvious.