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Does caffeine need to be diluted with novocaine? What happens if you inject caffeine intravenously? Use in neonatology

Mechanism of action on adipose tissue and skin

The way caffeine works is based on its ability to block the action of phosphodiesterase. As a result of enzyme suppression, cyclic adenosine monophosphate accumulates inside the cells of the body, which in turn leads to the activation of the processes of breakdown of glycogens and fats, metabolism in tissues and organs. In addition, caffeine promotes the loss of body fat by reducing tubular reabsorption of electrolytes.

The alkaloid has a tonic effect on the skin of the face and body. Due to its high lipid content, caffeine helps restore the water balance of the skin and accelerates regeneration processes. It normalizes the functioning of the sebaceous glands and produces a warming effect. After using caffeine, the color improves and the skin texture is evened out.

What aesthetic problems does caffeine solve?

The main indications for the use of the drug are local obesity, cellulite and the presence of a “double chin”. In addition, caffeine-containing compounds are used to treat baldness. In this case, the alkaloid, being a local irritant, promotes hair growth.

In cosmetology, procedures with caffeine allow:

  • Improve microcirculation in blood and lymphatic vessels.
  • Increase muscle tone, make the skin more toned and smooth.
  • Restore the water-lipid balance of the skin.
  • Reduce the appearance of pores on the face.
  • Remove excess fluid from the body, get rid of swelling.
  • Eliminate orange peel.
  • Lose weight due to body fat.

Contraindications to the use of the drug

  • Atherosclerosis.
  • Insomnia.
  • Severe hypertension.
  • Individual intolerance.
  • Increased excitability.
  • Old age.

Ways to use caffeine

Caffeine is often present in anti-cellulite creams and anti-aging serums. The concentrated drug is used in ultrasound and microcurrent therapy. Caffeine sodium benzoate in ampoules can be used for sessions (including home ones) of bipolar iontophoresis. The duration of this procedure is 10 minutes. This time is enough for the alkaloid to penetrate the skin to a depth of 0.5 cm under the influence of a small direct current.

In mesotherapy, caffeine is used both in pure form and as a composition. Since the alkaloid stimulates the sympathetic nervous system and increases blood pressure, it should not be used in large doses. For patients not prone to hypertension, up to 5 ml of caffeine can be administered during one session. For everyone else - no more than 2 ml. To obtain a meso-cocktail, caffeine is added to procaine, a mild pain reliever that relaxes the smooth muscles of blood vessels and connective tissue. In addition, this composition penetrates cell membranes better. Other components of cocktails, in addition to caffeine, may include ginkgo biloba and artichoke extracts, organic silicon, and L-carnitine.

Injection of caffeine-containing compounds is carried out either using the nappage technique or the papular technique. In the first case, a series of frequent injections of 0.02 ml is performed. In the area of ​​the face, neck and décolleté, the depth of needle insertion does not exceed 0.5 mm. If the purpose of a cosmetic procedure is to correct the figure or eliminate cellulite, deep nappage is performed. In order for the active substances to penetrate into the subcutaneous fatty tissue, injections are made to a depth of 10 mm. With the papular technique, the cosmetologist injects the drug so that “nodules” form in the dermis. The purpose of the manipulation is to improve the deposition of substances, thereby prolonging their therapeutic effect. The technique is used in the area of ​​the cheekbones, forehead, and lower jaw.

Carry out cosmetic procedures with drugs. containing caffeine, you can do it at home. To do this, use a special device -. With microneedling therapy, caffeine can be either a stand-alone product or a component of a cocktail. To carry out one procedure, you need to take 1–2 ml of the composition on the face, and 6 ml on the body. All necessary ingredients are collected and mixed using a syringe. Next, the skin is cleaned and disinfected. The drug is applied dropwise to the surface of the desired area by squeezing it out of a syringe. Then they pass the roller over the skin 4–6 times in each direction.

You can get acquainted with the prices and choose a meso cocktail in the section:

The modern rhythm of life requires a person to be completely involved in its whirlpool, which is why so many people desperately lack rest. How to overcome the resulting drowsiness? A cup of aromatic coffee often helps to disperse drowsiness and get into active mode. But this method does not always work. Therefore, many people choose an alternative - a drug called “Caffeine”. The instructions for use characterize it as a psychostimulant drug, the effectiveness of which is associated with the alkaloid it contains, produced from tea leaves (2% caffeine), coffee beans (1-2 percent) and cola nuts.

“Caffeine sodium benzoate,” which can be found in pharmacies, is a synthetic drug derived from these compounds.

Pharmacological properties (application)

A methylxanthine derivative, caffeine, has a psychostimulating and analeptic effect on the body. Its main property is the ability to improve motor activity, stimulate positive reflexes and various excitation processes occurring in the cerebral cortex. Thanks to this effect on the body, mental and physical activity increases, drowsiness disappears, and the feeling of fatigue decreases.

Caffeine can also increase blood pressure, but this occurs more often in states of shock or collapse. In small doses, caffeine provides a stimulating effect; in large doses, depression of the nervous system often occurs. What other effects does caffeine have? Instructions for use warn about increased and deepening of breathing when taking the drug, narrowing of blood vessels in the brain and a decrease in oxygen pressure in it. In cases of arterial hypotension, caffeine often normalizes blood pressure. The alkaloid has an antispasmodic effect on smooth muscles and a stimulating effect on striated muscles. Under the influence of caffeine, the secretory activity of the stomach increases and the basal metabolism increases (increased glycogenolysis, accelerated lipolysis). A moderate diuretic effect is also a consequence of caffeine consumption.

"Caffeine": indications for use

The drug is prescribed for diseases accompanied by a depressed state of the central nervous system, for disorders of the cardiovascular and respiratory systems (including poisoning with drugs, alcohol and toxins as a result of an infectious process), asphyxia, asthenia, enuresis (including in children), migraine, to relieve spasms of cerebral vessels. In ophthalmology, caffeine is used after eye surgery to reduce tone and retinal detachment.

This medicine is also indicated for decreased mental and physical performance, drowsiness, and to restore the optimal level of activity. A steady trend in recent years has been the use of this drug as a catalyst for the process of losing weight. In this case, the obligatory conditions are strict adherence to the dosage, doctor’s recommendations and physical activity. In cosmetology, the mixture of “Caffeine-sodium benzoate” and “Capsicam” has proven itself to be an effective anti-cellulite wrap.

Release form

“Caffeine sodium benzonate” (containing up to 40% caffeine) is available in the form of injection solution, tablets and powder (capsules).

Directions for use and dosage

How to take Caffeine correctly? Tablets, the instructions for use of which advise their use orally no more than 2-3 times a day, are prescribed for adults in a single dose of 100-200 mg (no more than 0.4 g) and a daily dose of no more than one gram, for children - according to 25-100 mg. Caffeine ampoules (1 ml) are intended for subcutaneous and subconjunctival administration.

Children are injected subcutaneously with a ten percent caffeine solution of 0.25-1 ml. In ophthalmology, a 10% caffeine solution in ampoules is also used: no more than 0.3 ml of the drug is dripped under the conjunctiva once a day. The dosage and duration of treatment are prescribed by the doctor and depend on the patient’s condition, as well as the nature of the disease. Caffeine sodium benzoate should not be taken before bed.

Contraindications

The instructions for use of the psychostimulant "Caffeine Benzoate" do not recommend prescribing it to people with arterial hypertension, increased excitability, sleep disorders (insomnia), those suffering from atherosclerosis, tachycardia, epilepsy, convulsions, increased intraocular pressure (glaucoma). The drug is also contraindicated for children under 12 years of age and elderly people. and should not be applied to affected areas of the skin.

Side effects

When taking a drug containing caffeine, the instructions for use advise paying attention to possible negative reactions of the body: from the central nervous system - anxiety, agitation, tremor, headache, restlessness, convulsions, dizziness, increased muscle tone, increased reflexes, insomnia, tachypnea . If the drug is abruptly discontinued, lethargy, drowsiness, fatigue, and increased inhibition of the central nervous system reaction may occur.

From the cardiovascular system, arrhythmia, tachycardia, and increased blood pressure are possible. From the gastrointestinal tract - nausea, exacerbation of peptic ulcers, vomiting, colic. With prolonged use, addiction and dependence on the drug is possible due to the formation of new adenosine receptors in the brain cells.

Overdose

What symptoms can excess caffeine cause? Instructions for use warn in such cases about increased severity of side effects: anxiety, confusion, mental and motor agitation, tremors or muscle twitching, epileptic seizures; dehydration, tachycardia, arrhythmia, headache, ringing in the ears, hyperthermia, frequent urination, nausea and vomiting.

The same conditions can occur after taking 300-600 mg (4 cups) of coffee per day, especially if combined with taking Caffeine Sodium Benzoate tablets.

Special instructions

During pregnancy and while breastfeeding, caffeine is taken only in cases of extreme necessity and under the supervision of a doctor! Abuse of the drug and drink threatens possible spontaneous abortion, slowing of intrauterine development, inhibition or disturbances in skeletal development, and arrhythmia in the fetus. During the lactation period, caffeine penetrates into breast milk and, accumulating, threatens insomnia in the baby and its hyperactivity.

"Caffeine": instructions for use, price, storage conditions and expiration date

The drug must be stored away from children, out of their reach, at temperatures up to 25 degrees, for no more than 5 years.

The cost of “Caffeine-sodium benzoate” tablets (6 pieces) in pharmacies today is approximately 32-40 rubles, a package of 10 ampoules (1 ml) of 20% solution is sold for 40-64 rubles.

Analogues

In addition to tablets produced in blisters of 6 or 10 pieces, as well as a solution for injection in ampoules, in pharmacies you can find drugs with various combinations of substances, which include caffeine. What other medications containing caffeine are listed in the instructions for use of medications? Expert reviews call the following analogues: “Askofen” (40 mg) and “Coficil Plus” (50 mg of the substance in question), “Migrenol” and “Solpadeine Fast” - 65 mg each, “Aquacitramon” (45 mg), as well as “Citramon” "and regular "Solpadeine" - 30 mg each. Among the drinks containing this common psychostimulant, reviews on forums mention coffee, tea, hot chocolate and soda (cola). The weight loss product Liquid Chestnut, which contains guaranine (an analogue of caffeine and theine), has a double concentration of caffeine.

Name:

Caffeine sodium benzoate (Coneinum natrii-benzoas)

Pharmacological
action:

Psychostimulant and analeptic agent, a methylxanthine derivative.
Competitively blocks central and peripheral A1 and A2 adenosine receptors.
Inhibits the activity of PDE in the central nervous system, heart, smooth muscle organs, skeletal muscles, adipose tissue, promotes the accumulation of cAMP and cGMP in them (this effect is observed when used only in high doses).
Stimulates the centers of the medulla oblongata (respiratory and vasomotor), as well as the n.vagus center, has a direct stimulating effect on the cerebral cortex.
In high doses facilitates interneuronal conduction in the spinal cord, enhancing spinal reflexes.
Increases mental and physical performance, stimulates mental activity, motor activity, shortens reaction time, temporarily reduces fatigue and drowsiness.
In small doses the stimulating effect predominates, and in large doses the effect of depression of the nervous system predominates.
Speeds up and deepens breathing.
Usually it has a positive ino-, chrono-, bathmo- and dromotropic effect (since the effect on the cardiovascular system consists of a direct stimulating effect on the myocardium and a simultaneous stimulating effect on the n.vagus centers, the resulting effect depends on the predominance of one or another action).

Stimulates the vasomotor center and has a direct relaxing effect on the vascular wall, which leads to dilation of the vessels of the heart, skeletal muscles and kidneys, while the tone of the cerebral arteries increases (causes a narrowing of the blood vessels in the brain, which is accompanied by a decrease in cerebral blood flow and oxygen pressure in the brain).
Blood pressure changes under the influence of vascular and cardiac mechanisms of caffeine's influence: with normal initial blood pressure, caffeine does not change or slightly increases it; with arterial hypotension, it normalizes it.
It has an antispasmodic effect on smooth muscles (including a bronchodilator effect), and a stimulating effect on striated muscles.
Increases secretory activity of the stomach.
It has a moderate diuretic effect, which is due to a decrease in the reabsorption of sodium and water ions in the proximal and distal renal tubules, as well as dilation of renal vessels and increased filtration in the renal glomeruli.
Reduces platelet aggregation and histamine release from mast cells.
Increases basal metabolism: increases glycogenolysis, increases lipolysis.

Indications for
application:

Infectious and other diseases accompanied by depression of the central nervous system and cardiovascular system (acute heart failure);
- respiratory depression;
- asphyxia;
- poisoning with drugs and other poisons that depress the central nervous system;
- asthenic syndrome;
- spasms of cerebral vessels;
- to increase mental and physical performance, eliminate drowsiness;
- used in children for enuresis.

Directions for use:

Inside And PC.
Doses are set individually, frequency of administration is no more than 2–3 times a day.
A single dose for adults is usually 1 ml of 10 or 20% solution; children are prescribed (depending on age) 0.25–0.1 ml of 10% solution.
Higher doses for adults for parenteral use: single - 0.4 g, daily - 1 g; when taken orally: single dose - 0.5 g, daily - 1.5 g.
It can be used as mono- or as part of combination therapy.

Side effects:

From the side of the central nervous system: sleep disturbance, agitation, anxiety; With prolonged use, addiction is possible.
From the cardiovascular system: tachycardia, increased blood pressure, arrhythmias.
From the digestive system: nausea, vomiting.

Contraindications:

Increased excitability;
- insomnia;
- severe hypertension;
- atherosclerosis;
- organic diseases of the cardiovascular system;
- old age;
- glaucoma;
- for the treatment of increased fatigue and drowsiness - children under 12 years of age.
With caution during pregnancy and lactation.

Interaction with
other medicinal
by other means:

With simultaneous use, the effect of sleeping pills and anesthetics is reduced.
With simultaneous use, it is possible to enhance the effect of analgesics-antipyretics, salicylamide, naproxen.
With the simultaneous use of estrogens (hormonal contraceptives, HRT agents) possible increase in intensity and duration of caffeine action due to inhibition of the CYP1A2 isoenzyme by estrogen.
When administered concomitantly with adenosine, caffeine reduces the increased heart rate and blood pressure changes caused by adenosine infusion; reduces vasodilation caused by the action of adenosine.
With simultaneous use, it is possible to increase the bioavailability, absorption rate and plasma concentration of acetylsalicylic acid.

With simultaneous use of mexiletine reduces caffeine clearance and increases its plasma concentrations, apparently due to the inhibition of caffeine metabolism in the liver by mexiletine.
Methoxsalen reduces the excretion of caffeine from the body with a possible increase in its effect and the development of toxic effects.
Due to the induction of microsomal liver enzymes under the influence of phenytoin during its simultaneous use Metabolism and elimination of caffeine are accelerated.
Fluconazole and terbinafine cause a moderate increase in the concentration of caffeine in the blood plasma, ketoconazole - less pronounced.
The most pronounced increase in AUC and decrease in clearance are observed with simultaneous use of caffeine with enoxacin, ciprofloxacin, pipemidic acid; less pronounced changes - with pefloxacin, norfloxacin, fleroxacin.
When used simultaneously, caffeine accelerates the absorption of ergotamine.

Pregnancy:

Given the slow elimination of caffeine from the fetus, its use during pregnancy is possible only after assessing the benefit/risk ratio for the mother and fetus.
Excessive caffeine consumption during pregnancy can lead to spontaneous abortions, slowing of intrauterine development of the fetus, and arrhythmias in the fetus; There may be disturbances in skeletal development when using large doses and a slowdown in skeletal development when using lower doses.
Caffeine and its metabolites pass into mother's milk in small quantities, but accumulate in infants and can cause hyperactivity and insomnia.
If it is necessary to use it during lactation, the benefit/risk ratio for the mother and child should be assessed.

Overdose:

Symptoms: gastralgia, agitation, anxiety, agitation, restlessness, confusion, delirium, dehydration, tachycardia, arrhythmia, hyperthermia, frequent urination, headache, increased tactile or pain sensitivity, tremor or muscle twitching; nausea and vomiting, sometimes with blood; ringing in the ears, epileptic seizures (in case of acute overdose - tonic-clonic).
Caffeine in doses of more than 300 mg/day (including against the background of coffee abuse - more than 4 cups of natural coffee, 150 ml each) can cause anxiety, tremor, headache, confusion, extrasystole.
In newborns (including premature infants), at a plasma caffeine concentration of 50 mg/ml, toxic effects are possible: anxiety, tachypnea, tachycardia, tremor, painful, bloated abdomen or vomiting, increased Moro reflex, and at higher concentrations - convulsions.
Treatment: gastric lavage if caffeine was taken in the last 4 hours at a dose of more than 15 mg/kg and there was no vomiting caused by caffeine; taking activated carbon, laxatives; for hemorrhagic gastritis - administration of antacid drugs and gastric lavage with an ice-cold 0.9% NaCl solution; maintaining pulmonary ventilation and oxygenation; for epileptic seizures - intravenous diazepam, phenobarbital or phenytoin; maintaining fluid and salt balance.
Hemodialysis, in newborns, if necessary, exchange blood transfusion.

Composition and release form of the drug

1 ml - ampoules (10) - cardboard packs.
2 ml - ampoules (10) - cardboard packs.

Pharmacological action

Psychostimulant and analeptic drug, a derivative of methylxanthine. Competitively blocks central and peripheral A1 and A2 adenosine receptors. Inhibits the activity of PDE in the central nervous system, heart, smooth muscle organs, skeletal muscles, adipose tissue, promotes the accumulation of cAMP and cGMP in them (this effect is observed when used only in high doses). Stimulates the centers of the medulla oblongata (respiratory and vasomotor), as well as the n.vagus center, has a direct stimulating effect on the cerebral cortex. In high doses, it facilitates interneuronal conduction in the spinal cord, enhancing spinal reflexes.

Increases mental and physical performance, stimulates mental activity, motor activity, shortens reaction time, temporarily reduces fatigue and drowsiness. In small doses the stimulating effect predominates, and in large doses the effect of depression of the nervous system predominates.

Speeds up and deepens breathing. Usually it has a positive ino-, chrono-, bathmo- and dromotropic effect (since the effect on the cardiovascular system consists of a direct stimulating effect on the myocardium and a simultaneous stimulating effect on the n.vagus centers, the resulting effect depends on the predominance of one or another action). Stimulates the vasomotor center and has a direct relaxing effect on the vascular wall, which leads to dilation of the vessels of the heart, skeletal muscles and kidneys, while the tone of the cerebral arteries increases (causes a narrowing of the blood vessels of the brain, which is accompanied by a decrease in cerebral blood flow and oxygen pressure in the brain).

Blood pressure changes under the influence of vascular and cardiac mechanisms of caffeine's influence: with normal initial blood pressure, caffeine does not change or slightly increases it; with arterial hypotension, it normalizes it.

It has an antispasmodic effect on smooth muscles (including a bronchodilator effect), and a stimulating effect on striated muscles.

Increases the secretory activity of the stomach.

It has a moderate diuretic effect, which is due to a decrease in the reabsorption of sodium and water ions in the proximal and distal renal tubules, as well as dilation of renal vessels and increased filtration in the renal glomeruli.

Reduces platelet aggregation and histamine release from mast cells.

Increases basal metabolism: increases glycogenolysis, increases lipolysis.

Indications

Diseases accompanied by depression of the central nervous system, functions of the cardiovascular and respiratory systems (including opioid poisoning, infectious diseases), cerebral vascular spasms, decreased mental and physical performance, drowsiness.

Contraindications

Arterial hypertension, organic diseases of the cardiovascular system (including severe), glaucoma, increased excitability, sleep disorders, old age.

Dosage

Administered subcutaneously or taken orally. Adults - 100-200 mg 2-3 times/day; children - 25-100 mg 2-3 times/day.

Side effects

From the side of the central nervous system: sleep disturbance, agitation, anxiety; With prolonged use, addiction is possible.

From the cardiovascular system: tachycardia, increased blood pressure, .

From the digestive system: nausea, vomiting.

Drug interactions

With simultaneous use, the effect of sleeping pills and anesthetics is reduced.

With simultaneous use, it is possible to enhance the effect of analgesics-antipyretics, salicylamide, naproxen.

With the simultaneous use of estrogens (hormonal contraceptives, drugs for HRT), it is possible to increase the intensity and duration of action of caffeine due to inhibition of the CYP1A2 isoenzyme by estrogens.

When administered concomitantly with adenosine, caffeine reduces the increased heart rate and blood pressure changes caused by adenosine infusion; reduces vasodilation caused by the action of adenosine.

With simultaneous use, it is possible to increase bioavailability, absorption rate and plasma concentration.

With simultaneous use, mexiletine reduces the clearance of caffeine and increases its plasma concentrations, apparently due to mexiletine inhibition of caffeine metabolism in the liver.

Methoxsalen reduces the excretion of caffeine from the body with a possible increase in its effect and the development of toxic effects.

Due to the induction of microsomal liver enzymes under the influence of phenytoin, its simultaneous use accelerates the metabolism and excretion of caffeine.

Fluconazole and terbinafine cause a moderate increase in the concentration of caffeine in the blood plasma, less pronounced.

The most pronounced increase in AUC and decrease in clearance are observed with simultaneous use of caffeine with enoxacin, ciprofloxacin, pipemidic acid; less pronounced changes - with pefloxacin, norfloxacin, fleroxacin.

When used simultaneously, caffeine accelerates the absorption of ergotamine.

Special instructions

It can be used as mono- or as part of combination therapy.

Caffeine is a drug that has a stimulating effect on the nervous system. Available in the form of tablets and solution for subconjunctival and subcutaneous administration.

Pharmacological action of Caffeine

Caffeine Sodium Benzoate is a psychostimulant drug, the active component of which in all forms of release is caffeine.

Caffeine has a stimulating effect on the cerebral cortex, stimulates the work of the vasomotor and respiratory centers of the medulla oblongata, and stimulates reflex activity. Caffeine Sodium Benzoate ensures interneuronal conduction of the spinal cord, increases motor activity and mental activity, prevents drowsiness and helps overcome symptoms of fatigue.

When using small doses of the drug, stimulation of the functions of the nervous system is noted. The use of Caffeine Sodium Benzoate in large doses leads to inhibition of the functions of the central nervous system.

The active component of the drug affects the cardiac and vascular mechanisms of the body, which leads to changes in blood pressure: due to caffeine, low or slightly increased normal pressure occurs.

Caffeine in ampoules and tablets can increase a person’s physical and mental performance, has an antispasmodic effect on smooth muscles and a stimulating effect on striated muscles. The drug increases diuresis and gastric secretory activity, and also reduces platelet aggregation and the release of histamine from mast cells.

Thanks to Caffeine, the body's basal metabolism increases: glycolysis increases and lipolysis increases.

The use of caffeine by older people slows down the onset of sleep, significantly reduces its duration and increases the frequency of night awakenings.

In premature infants, when using Caffeine Sodium Benzoate, there is an elimination of periodic breathing, a decrease in the partial pressure of carbon dioxide, and an increase in the volume of ventilation without changes in heart rate.

A mixture of Caffeine and Capsicam is effectively used in cosmetology.

Indications for use of Caffeine

In ampoules and tablets, Caffeine is prescribed for decreased mental and physical performance, for headaches of vascular origin, migraines, and infectious diseases.

It is recommended to take Caffeine Sodium Benzoate for moderate arterial hypotension, drowsiness, enuresis, respiratory depression in newborns resulting from asphyxia, poisoning with opioid analgesics, hypnotic drugs, carbon monoxide.

In surgical practice, the drug is used to restore the required level of pulmonary ventilation.

Caffeine is used in ophthalmology for decreased tone after surgery on the organs of vision, as well as for retinal detachment.

In cosmetology practice, a mixture of Caffeine and Capsicam is effectively used for wrapping procedures.

Directions for use and dosage

Caffeine tablets for adults are prescribed 50-100 mg 2-3 times a day, regardless of meals. The dose of the drug for children is 30-75 mg 2-3 times a day.

Caffeine in ampoules is intended for subcutaneous administration. The permissible single dose of the drug is 100-200 mg, the maximum daily dose is 600 mg. For children over 12 years of age, it is recommended to administer 25-100 mg of solution 2-3 times a day.

In ophthalmology, Caffeine Sodium Benzoate is also used in ampoules - the solution is injected into the area under the conjunctiva, 0.3 ml once a day. The frequency of drug administration is prescribed and adjusted by the attending physician and depends on intraocular pressure and the depth of the anterior ocular chamber.

To prepare an anti-cellulite mixture for wrapping, mix 4 ampoules of Caffeine, Capsicam ointment (the size of 2 peas) and baby cream (4 peas). The resulting substance should be applied to problem areas and covered with cling film. You need to keep the application for 3 hours. It is not recommended to take food or any liquids during and for two hours after the wrap. The course is equal to 10 procedures.

Side effects of Caffeine

Both solution and Caffeine tablets can cause the following undesirable effects:

  • feeling of restlessness, anxiety and agitation;
  • muscle tension;
  • increased fatigue;
  • insomnia;
  • rapid heartbeat;
  • headaches;
  • tremor;
  • tachypnea;
  • epileptic seizures.

Also, the body may experience tachycardia, arrhythmia, high blood pressure, and nasal congestion.

Caffeine affects peptic ulcers, causing them to worsen.

With prolonged use of tablets and solution in ampoules, caffeine is addictive and addictive.

When wrapping with a mixture of Caffeine and Capsicam, a hot burning sensation may occur in the area of ​​the procedure.

Contraindications for use

Caffeine is not prescribed for diseases of the cardiovascular system, anxiety disorders, tachycardia, arterial hypertension, ventricular extrasystole, as well as for acute sleep disorders.

The drug is contraindicated in children under 12 years of age, elderly people with epilepsy, glaucoma, seizures, as well as women during pregnancy and lactation.

The anti-cellulite mixture of Caffeine and Capsicam should not be applied to the affected areas of the skin.

Overdose

In case of an overdose of Caffeine Sodium Benzoate, acute states of anxiety, tremors, restlessness, headaches, cardiac extrasystoles, and confusion may occur.

Additional information

During therapy, it should be taken into account that the drug enhances the effect of sleeping pills and narcotics, aspirin, paracetamol and other non-narcotic analgesics.

With the simultaneous use of caffeine with drugs that contain mexiletine, there is a deterioration in the process of removing caffeine from the body. The simultaneous use of this medication with nicotine increases and accelerates its elimination.

Caffeine in all forms must be stored in a dark, cool place out of the reach of children. The shelf life of the drug is 60 months.