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Quercetin belongs to the chemical group. Positive effects of quercetin on the human body

Many people are interested in what is quercetin? This substance belongs to the group of vitamins P and is considered an aglycone of flavonoid plant glycosides, including rutin. In this material we will talk about this substance and the drug based on it.

So what is quercetin?

Vitamin P in its natural form is a plant flavonoid. According to experts, it has beneficial properties due to its special molecular structure. This is a powerful antioxidant that helps to successfully eliminate free radicals that damage cell membranes and DNA, and also cause cell death. Quercetin promotes longevity, maintaining the body in good shape, endurance, and strong immunity. According to experts, vitamin P is one of the most beneficial substances for the human body. But the most important advantage is that the most common products contain it. Let's figure out which foods contain quercetin.

In vegetables, green and black tea, fruits, buckwheat, onions, legumes, lingonberries, raspberries, leafy green vegetables, apples, cranberries, nuts, olive oil, tomatoes, blueberries, red wine.

What effect does it have on the body?

Flavonoids, including quercetin, act on the principle of antioxidants, that is, they have an inhibitory effect on oxidative processes that occur during the aging process. In addition, the substance has an antihistamine effect and is used as a remedy to relieve food allergies, as well as asthma and skin rashes. The substance helps release histamine from immune cells and stabilize it, which relieves allergic symptoms (eliminates cough, lacrimation, runny nose, hives, swelling). Quercetin reduces oxidative reactions, which has a positive effect on the cardiovascular system. People who consume foods containing flavonoids are much less likely to suffer from heart pathologies, including in old age.

The impossibility of free blood flow in the vessels is the main factor that causes heart attacks and strokes. Therefore, eating flavonoids is a good prevention of such diseases. Quercetin lowers the amount of “bad” cholesterol, which helps control blood pressure. In addition, this substance helps reduce pain in arthritis, prostatitis and infections of the genitourinary system. Based on the results of some studies, experts have concluded that vitamin P can reduce the risk of cancer cells.

It was found that flavonoids have a detrimental effect on malignant neoplasms. However, this fact was confirmed only by experiments on laboratory animals. In this regard, it can be recommended to include as many fruits and vegetables in your diet as possible for prevention purposes. If it is impossible to obtain a sufficient amount of a substance naturally, or if any pathologies occur, the doctor may prescribe medications that contain this substance. Such drugs include the drug "Quercetin". What is it?

Pharmacology

The drug has capillary stabilizing, radioprotective, regenerative and cardioprotective effects. In addition, there is an active antioxidant, pro-osteoclast, antispasmodic, anti-inflammatory, anti-sclerotic and diuretic effect. In pharmaceutical production, “Quercetin” is obtained by hydrolysis of rutin isolated from buckwheat or Japanese sophora. This drug is often used in the diet of bodybuilders, as it significantly increases performance and makes it possible to recover faster after training. This is confirmed by the instructions for the Quercetin product.

Composition and release form

The drug is produced in the form of tablets, capsules or granules, as well as in the form of a powder for diluting a solution. The active ingredient is quercetin, in addition to it, auxiliary components: glucose monohydrate, apple pectin, sugar.

Properties of the drug

According to the instructions for use, “Quercetin” reduces capillary permeability due to its stabilizing properties. The product exhibits membrane-stabilizing and antioxidant effects on blood vessels. The main active ingredient prevents hypooxygenase metabolism of arachidonic acid, which leads to the suppression of serotonin, leukotrienes, and other causative agents of inflammatory processes. Actually, it is this process that determines the anti-inflammatory effect of the drug.

The regenerative properties of the drug promote accelerated healing of erosions and wounds. "Quercetin" potentiates bone tissue remodeling and has a pronounced immunomodulatory effect. The cardioprotective effect of the drug is due to an increase in the energy balance of cardiomyocytes due to improved blood circulation and antioxidant effects. In addition, the drug helps normalize blood pressure, release insulin, inhibits thromboxane synthesis and increases platelet aggregation. Absorption occurs in the small intestine.

Indications for use of Quercetin

The drug is recommended for use in patients over 12 years of age for conditions related to the prevention and treatment of purulent inflammatory diseases, radiation injuries, erosions and ulcers of the oral mucosa, and periodontal disease. The indication for the use of the drug is the complex treatment of the following diseases: vertebral, pain and menopausal syndromes, neuroreflex manifestations of spinal osteochondrosis, neurocirculatory dystonia, chronic glomerulonephritis. In addition, the drug is considered an effective remedy in the treatment of diseases of the epigastric organs, as a prevention of ulcerative-erosive conditions that can be provoked by the use of NSAIDs. Taking Quercetin is indicated for the following diseases: neurocirculatory dystonia, functional angina pectoris II-III stage, coronary heart disease, bronchial asthma, chronic fatigue syndrome, chronic prostatitis, gout, cataracts.

Directions for use and dosage

The drug "Quercetin" is prescribed by a doctor. General recommendations are as follows: 1 g 2 to 5 times a day. The duration of treatment and dose are adjusted by the doctor according to the severity of the disease. The maximum therapeutic course is up to 6 weeks. Adolescents with a history of neurocirculatory dystonia are prescribed 2 g twice a day for a month.

The instructions allow the drug to be used topically and orally.

For topical use, two grams of granules are dissolved in 10 ml of water until a homogeneous thick mass is formed, and for oral use, one gram of granules must be dissolved in 100 ml of water.

For erosive and ulcerative lesions of the oral mucosa or periodontal disease, it is recommended to make one local application of the drug every day, which is first applied to a sterile napkin.

For complex treatment of purulent-inflammatory lesions of soft tissues, the drug is prescribed locally and orally in the indicated dosage: two gel applications per day, one gram of granules twice a day orally.

In order to prevent and treat local manifestations of radiation sickness, local and internal use of the product is recommended. Applications are made on damaged areas up to three times a day. Take one gram of granules orally up to four times. Persons who live in radiation-contaminated areas are prescribed one gram of granules orally twice a day.

If you need to cure coronary disease, chronic glomerulonephritis, neuroreflex symptoms of vertebral osteochondrosis, as well as to prevent ulcer formation when using anti-inflammatory non-steroidal medications, take one gram of granules orally 3 times a day.

When treating neurocirculatory dystonia, two grams of granules are prescribed orally 2 times a day for a month. For complex treatment of vertebralgia or menopausal syndrome, one gram of granules is prescribed 3 times a day.

Contraindications

Quercetin tablets are prohibited for use in case of individual intolerance to the components of the drug, children under 12 years of age, pregnancy and breastfeeding.

Side effects

Allergic manifestations, expressed in the form of skin rash and itching, are possible as adverse reactions. In this case, you should stop taking the medicine and seek advice from a medical institution.

Drug interactions

Ascorbic acid, when taken together, enhances the effect of Quercetin. We explained what this is. This drug significantly enhances the anti-inflammatory effect of non-steroidal drugs.

Storage conditions and shelf life

The medicine is stored in a dry, dark place out of the reach of children. It must be used within two years from the date of issue.

It should be recalled that “Quercetin” is more of a food supplement, so you cannot deprive yourself of medical care; this product can and should be used only in combination with medications prescribed by your doctor.

General information

Quercetin is a widely distributed substance in nature, found in plants and fruits. Belongs to the group of vitamins P. Since the 1980s, scientists have been studying its effectiveness in various branches of medicine (including in the prevention of diseases of the cardiovascular system, Alzheimer's disease and others).

Physico-chemical properties

Metabolism

Main sources

Quercetin has an antioxidant effect, reducing peroxide stress.

In addition, it has an anti-inflammatory effect.

Based on clinical data, it has been established that quercetin is able to reduce blood pressure in people in a state of prehypertension.

Consumption standards

Quercetin is not a substance required for consumption. However, it is recommended to get flavonoids, including quercetin:

150–250 mg/day for children 7–18 years old,

250 mg/day for adults.

Symptoms of deficiency

Not known.

Indications for use

There are reasons to use quercetin under conditions of increased oxidative stress. In addition, quercetin may complement anti-inflammatory therapy.

The use of quercetin for prehypertension may reduce blood pressure.

Safety

Safe. The effect of long-term use of high doses has not been assessed.

Features of reception and interaction

Not known.

General information

Physico-chemical properties

Quercetin is a flavonoid, 3,3",4",5,7 is a pentahydroxyflavone. It is a lemon-yellow crystal, slightly soluble in water, alcohols and ethers, highly soluble in acetic acid and alkalis. An alcohol solution of quercetin has a very bitter taste. T. pl. = 314 °C, melts with decomposition. In nature it is present mainly in the form of glycosides.

Metabolism

Quercetin is absorbed in the small intestine by passive diffusion. It is better absorbed in the form of a glycoside - about half the dose. In the cells of the intestines, liver and kidneys it undergoes active biotransformation through methylation, sulfonation and glucuronidation.

Main sources

Quercetin is found in plants and fruits that are predominantly red and crimson in color: onions (especially red), apples, peppers, garlic, red grapes, citrus fruits, dark cherries, lingonberries, tomatoes, broccoli, raspberries, blueberries, cranberries, rowan, sea buckthorn, nuts, cauliflower and cabbage. The quercetin content is also high in green tea, some types of honey (eucalyptus, tea tree), red wine, and olive oil. In the Northern European diet, quercetin makes up up to 70% of the total flavonols entering the body, that is, about 17 mg/day.

Functions

Quercetin has an antioxidant effect, reducing peroxide stress. In addition, it has an anti-inflammatory effect. Based on clinical data, it has been established that quercetin is able to reduce blood pressure in individuals in a state of prehypertension.

Consumption standards

Quercetin is not a substance required for consumption. However, it is recommended to receive flavonoids, including quercetin: 150–250 mg/day for children 7–18 years old, 250 mg/day for adults.

Symptoms of deficiency- are not known.

Indications for use

There are reasons to use quercetin under conditions of increased oxidative stress. In addition, quercetin may complement anti-inflammatory therapy. The use of quercetin for prehypertension may reduce blood pressure.

Safe. The effect of long-term use of high doses has not been assessed. Features of reception and interaction are not known.

Quercetin- a widespread substance contained in plants of predominantly red, crimson color: onions (especially red; the content is higher in the outer shells), peppers, garlic, golden mustache, red grapes, tea, citrus fruits, dark cherries, apples, blueberries, black and green tea, red wine, green leafy vegetables, legumes, lingonberries, tomatoes, broccoli, tops, raspberries, blueberries, cranberries, chokeberries, rowan berries, sea buckthorn, crowberry, prickly pear fruits, some types of honey (eucalyptus, tea tree), nuts, cauliflower and cabbage, red wine, olive oil... Scientific research into quercetin has been conducted over the past 30 years, with recent work confirming that the compound is 400 times more powerful than vitamin E in eliminating the potential heart threat from cholesterol.

Quercetin is an antioxidant that helps us fight aging, a “building material” that strengthens the walls of our cells, and a powerful anti-inflammatory substance. This substance is especially useful for capillaries - small vessels that nourish all our organs. Very often, with various diseases, the walls of the capillaries begin to collapse. And then our organs, deprived of nutrients and oxygen, become ill. If we normalize capillary blood circulation, then many health problems will disappear on their own.

Quercetin belongs to the vitamin preparations of group P. It is used for the prevention and treatment of cerebrovascular disorders; diseases of the heart and blood vessels. This first-class “cleaner” of blood vessels improves blood flow, reliably protects microvessels and cell membranes from free radicals that destroy the body. It perfectly relieves headaches associated with cerebral vascular spasms, improving the general psycho-emotional state; restores vigor and activity. Quercetin protects cell membranes, inhibits the aging process of skin cells, myocardium and cornea. It is an inhibitor of the enzyme aldoreductase, which converts blood glucose into sorbitol. Quercetin has a positive effect on reducing the accumulation of sorbitol in the lens, thereby slowing down the formation of cataracts. A sufficient level of daily intake of quercetin is of important preventive value for diseases and vision disorders.

Quercetin strengthens the immune system by accelerating the production of natural detoxification enzymes. Due to its natural anti-inflammatory properties, quercetin may be useful in treating inflammatory diseases such as arthritis and asthma, and protecting the stomach from the development of peptic ulcers and gastric disorders. Quercetin is also used to relieve allergy symptoms.
Finnish scientists have found that men with higher levels of quercetin in their bodies are 60% less likely to develop lung cancer and 20% less likely to develop diabetes or heart failure. Scientists from Cornell University, one of the largest in the United States, believe that quercetin, by protecting brain cells, helps fight Alzheimer's disease.

(eng. Quercetin) is an active substance belonging to bioflavonoids - plant compounds that play a very important role in maintaining health and protecting the body from many diseases. , together with substances such as rutin, hesperidin and luteolin, is part of vitamin P.

Quercetin: content in products

In nature quercetin It is found quite often, but the largest amount is found in plants and fruits that are red or purple in color. Among them, the richest sources of this flavonoid are the following foods:

buckwheat,
red onion (especially its peel),
red wine,
dark apples,
dark cherries,
red grapes,
tomatoes,
cowberry,
cranberry,
raspberry,
beans,
nuts,
rowan, especially chokeberry,

Besides, quercetin It is found in large quantities in some green leafy vegetables - broccoli, cauliflower and cabbage.

Quercetin: beneficial properties

It has a wide range of beneficial properties for the human body, therefore it is widely used for medical purposes:

Quercetin: norms and rules of use

It is not a vital substance, but to maintain the health of the body, doctors still recommend consuming flavonoids, and quercetin including in the following dosages:

250 mg per day for adults,
from 150 to 250 mg for children over 7 years of age.

Obtained from food, even in large quantities, is not capable of causing any harm to the human body. However, its increased doses (over 4 g per day), taken in the form of tablets or aqueous solutions, can accumulate in tissues and negatively affect the condition and function of the kidneys. This is why taking supplements containing quercetin, is not recommended for people suffering from kidney disease, pregnant and lactating women.

Quercetin: interactions

Being an antioxidant, quercetin actively interacts with other antioxidants, and primarily with. Thanks to the synergism of these two substances, their beneficial effects on the body are significantly increased. Besides, quercetin prevents oxidation and destruction in the body.

Better assimilation of the quercetin and the enzyme enhances its beneficial effect.

Quercetin: buy, price

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Name: Quercetin

Name: Quercetin (Quercetinum)

Indications for use:
The drug is used in adults and children over 12 years of age for the prevention and treatment of local radiation injuries after x-ray and gamma radiation therapy; treatment of periodontal disease, erosive and ulcerative diseases of the oral mucosa; purulent-inflammatory diseases of soft tissues; in the complex treatment of menopausal, vertebral pain syndrome; neuroreflex manifestations of spinal osteochondrosis; chronic glomerulonephritis; to prevent erosive and ulcerative lesions of the upper parts of the digestive canal caused by taking non-steroidal anti-inflammatory drugs. The drug is used for neurocirculatory dystonia, coronary heart disease, angina pectoris II - III FC.

Pharmacological action:
Capillary stabilizing, cardio- and radioprotective, regenerative, also pro-osteoclast agent, which has antioxidant, anti-inflammatory, antispasmodic, antiulcerogenic, diuretic, antisclerotic properties.

Quercetin method of application and dosage:
For topical use, 2 g of Quercetin granules are dissolved in 10 ml of hot water (or 1 g in 5 ml) and stirred to form a gel. For periodontal disease and erosive and ulcerative diseases of the oral mucosa, one application of gel is made every day, which is first applied to sterile napkins.
For patients living in areas contaminated with radionuclides, Quercetin is prescribed orally for adults and children over 12 years of age, 1 g (1/2 teaspoon) 2 times a day. It is recommended to take quercetin 30 minutes before meals, after adding 1/2 cup of water to the granules. The duration of the course of treatment is determined by the doctor.
In the complex therapy of purulent-inflammatory diseases of soft tissues, Quercetin is prescribed to adults and children over 12 years of age topically and orally in the same doses: topically - 2 g of Quercetin granules per 10 ml of hot water (or 1 g in 5 ml), orally - 1 g (1/2 teaspoon) per 1/2 glass of water, 2 times a day.
For the prevention and treatment of local lesions during radiation sickness, the product is prescribed locally and orally. Gel applications to damaged parts of the body are carried out 2-3 times a day.
Orally, adults and children over 12 years of age are prescribed 1 g 3 to 4 times a day. To do this, add 1/2 teaspoon of Quercetin granules (1 g) to 1/2 glass of water, infuse and take 30 minutes before meals. The course of treatment is determined by the doctor. For adult patients with neuroreflex manifestations of spinal osteochondrosis, chronic glomerulonephritis, coronary heart disease, menopause, vertebral pain syndrome, also to prevent the ulcerogenic effect of non-steroidal anti-inflammatory drugs, the product is prescribed at a dose of 3 g per day. When used together with non-steroidal anti-inflammatory drugs, it can be used in a dose of 6 g (3 times a day, 2 g) to prevent the manifestations of gastric ulcers.
Adolescents who suffer from neurocirculatory dystonia are prescribed 2.0 g of Quercetin granules twice a day for a month.

Quercetin contraindications:
Allergy to product components.

Quercetin side effects:
Increased individual sensitivity (rash, itching) is possible.
If any unusual reactions are detected, you should stop using the product and consult a doctor for advice.

Pregnancy:
Although Quercetin is a practically non-toxic product, it is not advisable to use it during pregnancy, especially in the first trimester of pregnancy; It is also not recommended to take the product during lactation.

Overdose:
With long-term use, manifestations of hypersensitivity to the product in the form of allergic reactions are possible, which requires symptomatic therapy.

Use with other medications:
When Quercetin is combined with ascorbic acid products, an increase in effects is observed.
When the product is combined with non-steroidal anti-inflammatory drugs, the anti-inflammatory effect is enhanced subsequently.

Release form:
Granules in bags of 2 g.

Storage conditions:
Store out of reach of children, in a dry, dark place at a temperature not exceeding 25 °C.
Shelf life. 2 years.
The drug cannot be used after the expiration date indicated on the package has expired.
Rules for dispensing from pharmacies - without a prescription.

Quercetin composition:
Active ingredient: quercetin;
100 g of granules contain 4 g of quercetin;
excipients: apple pectin, glucose, sugar.

Additionally:
If the signs of the disease do not begin to disappear, or your health condition worsens, or undesirable effects appear, you should stop taking the product and consult a doctor regarding further use of the product. There are no data from clinical trials in children under 12 years of age.

Attention!
Before using the medication "Quercetin" You should consult your doctor.
The instructions are provided for informational purposes only. Quercetin».

Instructions

for medical use

medicine

Quercetin

Trade name

Quercetin

International nonproprietary name

Dosage form

Granules 2 g

Compound

1 g of granules contains

active substance - quercetin (based on 100% dry matter) 0.04 g,

excipients: apple pectin, glucose monohydrate, sugar.

Description

Yellow granules with a greenish tint.

PharmacotherapeuticYesgroup

Angioprotectors. Drugs that reduce capillary permeability. Other drugs that reduce capillary permeability.

Code ATX С05С Х

Pharmacological properties

Pharmacokinetics

The drug is well absorbed. Other pharmacokinetic parameters have not been studied.

Pharmacodynamics

The flavonoid quercetin is a non-carbohydrate biologically active component of many plant flavonoid glycosides, including rutin, and belongs to vitamin preparations of group P. Due to capillary-stabilizing properties associated with antioxidant, membrane-stabilizing effects, the drug reduces capillary permeability. Quercetin has an anti-inflammatory effect as a result of blocking the lipoxygenase pathway of arachidonic acid metabolism, reduces the synthesis of leukotrienes, serotonin and other inflammatory mediators.

Quercetin exhibits an antiulcer effect associated with the use of anti-inflammatory drugs, and also has radioprotective activity (after X-ray and gamma irradiation).

The cardioprotective properties of Quercetin are due to an increase in the energy supply of cardiomyocytes due to its antioxidant effect and improved blood circulation.

The reparative properties of Quercetin are manifested in accelerated wound healing. The drug can influence the processes of bone tissue remodeling; it exhibits persistent immunomodulatory activity.

Diuretic, antispasmodic, and antisclerotic properties have also been experimentally determined. Quercetin is able to normalize blood pressure and stimulate the release of insulin, accelerate platelet aggregation, and inhibit thromboxane synthesis.

Quercetin also binds to estrogen receptors. Due to estrogen-like properties (effect on proline hydroxylase, inhibition of tumor necrosis factor and synthesis of interleukins), the drug has pro-osteoclast effects.

Indications for use

Prevention of erosive and ulcerative lesions of the upper digestive canal caused by taking non-steroidal anti-inflammatory drugs

as part of combination therapy

Local radiation injuries after x-ray and gamma irradiation therapy, as well as for their prevention

Erosive and ulcerative diseases of the oral mucosa, periodontal disease

Purulent-inflammatory diseases of soft tissues

Menopausal syndrome

Vertebral pain syndrome

Neuroreflex manifestations of osteochondrosis

Chronic glomerulonephritis

Neurocirculatory dystonia

Coronary heart disease and angina pectoris of II-III functional class

Directions for use and doses

Quercetin is used for topical and internal use. Prescribed for adults.

For local use: 2 g of Quercetin granules are dissolved in 10 ml of water at a temperature of 45-50 ºС until a homogeneous viscous mass (gel) is formed.

For internal use: 1 g (1/2 teaspoon) of Quetsetin granules is dissolved in 100 ml of warm water.

At periodontal disease and erosive and ulcerative diseases of the oral mucosa One application of gel is made daily, which is first applied to a sterile napkin.

In complex therapy of purulent-inflammatory diseases of soft tissues Quercetin is prescribed locally and orally in the same doses: locally - gel applications of 2 g of Quercetin granules 2 times a day, orally - 1 g (1/2 teaspoon) of granules 2 times a day.

For prevention and treatment of local lesions due to radiation sickness the drug is prescribed locally and orally. Gel applications are applied to damaged areas of the body 2 - 3 times a day. 1 g is prescribed orally 3-4 times a day 30 minutes before meals. For patients living in areas contaminated with radionuclides, Quercetin is prescribed orally 1 g (1/2 teaspoon) granules 2 times a day 30 minutes before meals.

In complex treatment neuroreflex manifestations of spinal osteochondrosis, chronic glomerulonephritis, coronary heart disease, and also to prevent ulcerogenic effects of non-steroidal anti-inflammatory drugs the drug is prescribed orally in a dose of 1 g per dose 3 times a day. When used simultaneously with non-steroidal anti-inflammatory drugs, adults can take Quercetin orally at a dose of 2 g per dose 3 times a day.

At neurocirculatory dystonia The drug is prescribed orally, 2 g of Quercetin granules twice a day for a month.

In complex treatment climacteric, vertebral pain syndrome include taking Quercetin granules 1 g 3 times a day. The treatment period is 6 months.

Side effects

Allergic reactions (rash, itchy skin, angioedema)

Dry mouth, nausea

Headache, tingling sensation in fingers

Moderate hypotension.

Contraindications

Hypersensitivity to quercetin, drugs with P-vitamin activity and/or other components of the drug

Severe arterial hypotension

Pregnancy and lactation

Children and teenagers up to 18 years of age.

Drug interactions

When using Quercetin together:

With ascorbic acid preparations, a summation of effects is observed;

With non-steroidal anti-inflammatory drugs, the anti-inflammatory effect of the latter is enhanced;

With organic nitrates, quercetin can cause arterial hypotension;

With fibrinolytics, quercetin leads to an increase in the effectiveness of thrombolytic therapy;

With digoxin, the maximum serum concentration and the total area under the concentration-time curve of digoxin increase;

With cyclosporine, the bioavailability and concentration in the blood of cyclosporine increases;

With paclitaxel, the metabolism of the latter is affected;

With verapamil, the bioavailability of the latter increases;

With tamoxifen, bioavailability increases, metabolism and excretion of the latter decreases.

Special instructions

With prolonged use, manifestations of hypersensitivity to the drug in the form of allergic reactions are possible.

Since the drug contains sucrose and glucose, patients with hereditary fructose intolerance, glucose-galactose malabsorption syndrome, and sucrose-isomaltose malabsorption syndrome should not use the drug.

Use in pediatrics

There is no experience of clinical use of the drug in children and adolescents under 18 years of age.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

There is no data on the effect of the drug on the patient’s ability to drive a vehicle or operate potentially dangerous machinery.

Overdose

Symptoms: rash, itchy skin.

Treatment: drug withdrawal; carrying out desensitizing therapy.

Release form and packaging