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Thiamine bromide instructions for use. Thiamine

Thiamine

Compound

4-methyl-5-b-oxyethyl-N-(2-methyl-4-amino-5-methyl-pyrimidyl)-thiazolium bromide hydrobromide (or hydrochloride).
Thiamine bromide is a white or white powder with a slightly yellowish tint. The drug has a faint characteristic odor of yeast. Easily soluble in water. The solution (pH 2.7 - 3.6) is sterilized at +100 "C for 30 minutes.

Pharmacological action

It has a positive effect on the conduction of nerve excitation in synapses (at the sites where nerve excitation is transmitted). Has moderate ganglion-blocking properties. With a reduced content of thiamine in food, a person develops hypovitaminosis Bi (reduced intake of vitamin Bi into the body), and then vitamin deficiency Bi (lack of intake of vitamin Bi into the body) - Beri-Beri disease.

Indications for use

Hypovitaminosis and vitamin deficiency in various forms of neuritis (nerve inflammation). Radiculitis, neuralgia (pain spreading along the nerve). Peripheral paresis (decreased strength and/or range of movements) and paralysis (lack of voluntary movements due to impaired nervous regulation of muscles) of various origins. Meniere's disease (a disease of the inner ear characterized by recurrent dizziness, nausea, and vomiting). Korsakov's psychosis (chronic alcoholism, characterized by memory disorder, disease of the peripheral nervous system, social personality disorders). Poliomyelitis (an acute infectious disease characterized by impaired movement) and encephalomyelitis (combined inflammation of the brain and spinal cord). Wernicke's disease (a cerebrovascular disease manifested by mental disorders, motor coordination disorder, and visual impairment). Peptic ulcer of the stomach and duodenum. Atony (loss of tone) of the intestines. Myocardial dystrophy (a disease of the heart muscle associated with a violation of its nutrition). Disturbances of coronary (through the vessels of the heart) blood circulation in patients with angina pectoris. Thyrotoxicosis (thyroid disease). Endarteritis (inflammation of the inner lining of the arteries). Neurogenic dermatoses (skin diseases due to changes in the activity of the nervous system). Herpes zoster (a viral disease of the central and peripheral nervous system with the appearance of rash blisters along the sensory nerves). Psoriasis. Eczema. Poisoning (carbon disulfide, tetraethylene lead, mercury, methyl alcohol, arsenic, etc.).

Directions for use

For medicinal purposes, thiamine chloride and thiamine bromide are used orally (after meals) and parenterally (bypassing the gastrointestinal tract).
Oral doses of thiamine chloride for adults are 0.01 g (10 mg) 1-3 (up to 5) times a day. Children under 3 years of age are prescribed 0.005 g (5 mg) every other day; 3-8 years - 0.005 g 3 times a day every other day; over 8 years old - 0.01 g 1-3 times a day. The course of treatment is usually 30 days.
Thiamine bromide, due to its higher relative molecular weight (435.2), is used in slightly larger doses than thiamine chloride (relative molecular weight 337.27); 0.001 g (1 mg) of thiamine chloride corresponds in activity to 0.00129 g (1.29 mg) of thiamine bromide.
If absorption in the intestine is impaired and if it is necessary to quickly create high concentrations of vitamin Bi in the blood, thiamine chloride or thiamine bromide is administered parenterally. Typically, adults are administered intramuscularly with 0.025-0.05 g of thiamine chloride (1 ml of 2.5% or 5% solution) or 0.03-0.06 g of thiamine bromide (1 ml of 3% or 6% solution) 1 time per day daily; children are administered 0.0125 g (0.5 ml of a 2.5% solution) of thiamine chloride or 0.015 g (0.5 ml of a 3% solution) of thiamine bromide. The course of treatment is 10-30 injections.
The daily requirement for vitamin Bi is about 2 mg for an adult; With heavy physical work, the need for the vitamin increases slightly. Daily doses for children: from 6 months of age. up to 1 year - 0.5 mg; from 1 year to 1.5 years - 0.8 mg; from 1.5 to 2 years - 0.9 mg; from 3 to 4 years - 1.1 mg; from 5 to 6 years - 1.2 mg; from 7 to 10 years - 1.4 mg; from 11 to 13 years - 1.7 mg; for boys 14-17 years old - 1.9 mg; for girls 14-17 years old - 1.7 mg.

Side effects

In some cases, especially with parenteral administration, allergic reactions and even anaphylactic (allergic) shock are possible.

Contraindications

History of allergic diseases (previous).

Release form

Available in the form of thiamine bromide: powder 1 g; dragees 0.002 g in a package of 50 g; tablets with a score of 0.0129 g in a package of 50 pieces; ampoules of 1 ml in packs of 10 pieces of 3% and 6% solution and thiamine chloride: ampoules of 1 ml in packs of 50 pieces of 2.5% and 5% solution.

Storage conditions

In a place protected from light. Attention!
Description of the drug " Thiamine"on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Vitamin B t (Vitaminum B,) Thiamine*

PHARMACOLOGICAL ACTION

Thiamine is phosphorylated to form thiamine pyrophosphate, which mediates the many effects of thiamine. After oral administration, it is absorbed mainly in the duodenum and small intestine. Quickly and completely absorbed by intramuscular injection. Distributed throughout all tissues. Approximately 1 mg is metabolized daily. The daily requirement for vitamin B1 for adult men is from 1.2 to 2.1 mg; for elderly people - 1.2-1.4 mg; for women - 1.1-1.5 mg with the addition of 0.4 mg for pregnant women and 0.6 mg for lactating women; for children, depending on age, 0.3-1.5 mg. In the form of thiamine pyrosphate, as a coenzyme of numerous decarboxylases, it is involved in the metabolism of pyruvate, alpha-ketoglutarate and plays an important role in carbohydrate metabolism. Protects cell membranes from the toxic effects of peroxidation products.

INDICATIONS FOR USE

Hypovitaminosis and vitamin B1 deficiency (including in patients on tube feeding, on hemodialysis, suffering from malabsorption syndrome). Reduced intake of vitamin into the body - impaired absorption in the intestines, fasting; chronic alcoholism; severe liver dysfunction; thyrotoxicosis. Increased need for vitamin - pregnancy, lactation, period of intensive growth. Neuritis, radiculitis, neuralgia, peripheral paresis or paralysis, intestinal atony, myocardial dystrophy, dermatoses, lichen, psoriasis, eczema, intoxication.

CONTRAINDICATIONS

Hypersensitivity.

SIDE EFFECTS

Allergic reactions - Quincke's edema, urticaria, itching.

INTERACTION

Weakens the effect of depolarizing muscle relaxants (ditilin, etc.). Pyridoxine inhibits the conversion of thiamine to cyanocobalamin and increases allergization. Pharmaceutically incompatible (in one syringe) with penicillin, streptomycin, nicotinic acid.

METHOD OF APPLICATION AND DOSES

Orally (after meals) and parenterally. The oral dose for adults is 10 mg 1-3 (up to 5) times a day. Children under 3 years of age are prescribed 5 mg every other day; 3-3 years - 5 mg 3 times a day every other day; over 3 years - 10 mg 1-3 times a day. The course of treatment is 30 days. Parenteral administration is recommended to start with small doses (no more than 0.5 ml of a 5% or 6% solution), and only if well tolerated, higher doses are administered. Children - 0.0125 g of thiamine chloride (0.5 ml of 2.5% solution) or 0.015 g of thiamine bromide (0.5 ml of 3% solution). IM for adults - 0.02-0.05 g of thiamine chloride (1 ml of 2.5% or 5% solution) or 0.03-0.06 g of thiamine bromide (1 ml of 3% or 6% solution) 1 once a day, daily, course - 10-30 injections.

RELEASE FORM

Table 0.00258; 0.0129; 0.0645

R-r d/in. 3%; 6% 1 and 2 ml

Medicine thiamine popularly known as vitamin B1(in old medical reference books it is also called anervin).

Thiamine is one of the most important chemical compounds for the body. However, its lack is by no means uncommon.

By the beginning of the twenty-first century, it was discovered that there are four forms of thiamine in the human body, the most common being thiamine diphosphate.

Properties of vitamin B1

Thiamine in its original form is translucent crystals, soluble in water and insoluble in alcohol solutions, but destroyed when heated.

Strongly expressed does not smell of vitamin B1.

Thiamine in the human body is stored mainly in muscles. It was also found in organs such as the heart, liver, brain and kidneys, but in much lower concentrations. Vitamin B1 does not accumulate in the body and is not capable of performing a toxic function.

Chemical formula vitamin B1: C₁₂H₁₇N₄OS+

Structural formula showing the structure of vitamin B1:

The role of vitamin B1 in the body

Thiamine is indispensable for the normal functioning of the nervous and endocrine systems, which are directly related to the aging process. A proper diet and consumption of thiamine in sufficient quantities and in an easily digestible form can hide a person’s true age, slowing down the natural aging process from the inside.

If you pay attention to the long chemical formula of thiamine, you can find in it the Latin letter N, denoting nitrogen. Nitrogen is necessary for building protein in the body; its deficiency has a detrimental effect on muscle strength and health.

Thiamine - “vitamin of optimism”

A sufficient amount of thiamine in the body helps to keep oneself in good shape, look at the world optimistically, and prevents the development of manic-depressive states.

Panic attacks, annoying fears, increased nervousness, depression and the depersonalization that often accompanies it are much more likely to bypass a person who consumes enough thiamine.

Interesting fact about vitamin B1. Research at Princeton (USA), at the Center for Brain Biology, has revealed a direct relationship between stress resistance, nervous system health and adequate intake of vitamin B1.

Thiamine also contributes to the normal functioning of the gastrointestinal tract and improves appetite.

History of the discovery of thiamine

Thiamine was first discussed after the discovery of beriberi disease in Asia, which is caused by a lack of vitamin B1 in the body.

Beriberi disease

Beri Beri, leg swelling

Thiamine deficiency has a detrimental effect on muscle health and strength, with the legs usually being the first to suffer.

heaviness, weakness in legs are the first symptoms of vitamin deficiency, or beriberi disease.

In the modern world, severe forms of vitamin deficiency are extremely rare.

The bulk of cases are recorded in Asia, where part of the population eats mainly a few types of rice containing too little or no thiamine.

The symptoms of beriberi are many times exaggerated consequences of a lack of thiamine in the body.

Patients are characterized by increased nervous excitability and lethargy (beriberi is translated from one of the eastern languages as “ I can't, I can't"), unsteady gait or muscle paralysis caused by their general weakness, loss of appetite and, as a result, weight loss.

Main symptoms:

loss of appetite;
nausea and vomiting;
pain in the legs while walking;
insomnia;
increased nervous excitability;
decreased mental and physical performance;
decreased pain sensitivity in the feet.

Happens dry beriberi, the result of which can be severe damage to the middle parts of the brain. Wet beriberi entails disruption of the heart and blood vessels. Children's beriberi is somewhat different in symptoms from the course of this type of vitamin deficiency in adults.

The disease can develop acutely or gradually. In the acute form, pain in the legs when walking, numbness in the feet (and sometimes in the hands) and weakness occur sharply within twenty-four or forty-eight hours. With a long-term lack of thiamine, chronic beriberi develops.

Another name for beriberi disease is polyneuritis. Today, it more often affects chronic alcoholics, since alcohol greatly interferes with the absorption of vitamin B1.

Polyneuritis is treated with vitamin injections and a special fortified diet aimed at eliminating thiamine deficiency in the body. They also take special medications that support the gastrointestinal tract and digestive system, which also suffer from a lack of thiamine.

How does vitamin B1 help in different situations?

Children most in need of thiamine are during periods of intensive growth and children of primary school age who are adapting to new physical and intellectual stress.

The vitamin is also important for people over fifty years of age due to its ability to slow down natural aging processes in the body.

According to statistics, about forty percent of young people between the ages of twenty-five and thirty are deficient in thiamine.

Thiamine and alcohol use

Alcoholic drinks greatly interfere with the absorption of vitamin B1. It is not without reason that people at risk of vitamin deficiency are identified as chronic alcoholics. In addition, alcohol also contributes to the occurrence of cancer of the oral cavity, larynx and esophagus.

Attention. Mixing B vitamins and alcohol will not have a harmful effect on the body and will not cause a severe hangover or rapid intoxication. It’s just that the beneficial substances are almost not absorbed by the body.

Sometimes you can hear the opinion that taking a “shock” dose of B vitamins before an alcoholic party will help you quickly sober up and relieve fumes and hangovers.

This is only partly true.

Indeed, vitamins B1, B6 and vitamin C are used to get people out of binge drinking, with alcohol intoxication, and B1 generally “specializes” in a quick sobering effect.

However, it should be borne in mind that taking a large dose of vitamins together can cause overdoses and side effects such as loss of orientation in space, dizziness, rashes and other skin irritations.

Vitamin B6, taken in the dosage indicated in the instructions twelve and four hours before an alcoholic party, can significantly relieve future hangovers. Multivitamin complexes will not be effective as preventive measures of this kind.

For alcohol intoxication

In case of an overdose of alcohol, the body expends enormous energy to fight the poisoning. B vitamins, which do not accumulate in the body anyway, are urgently used to break down alcohol and help the stomach fight the aggressive alcohol environment.

With long-term heavy drinking, a lack of vitamins in the body first develops.

The best way to deliver vitamins to the body is to inject them directly into the blood (this way they will begin to act faster). In conjunction with thiamine, it is recommended to use B6 (stimulates liver activity) and C. These same vitamins are also found in most anti-hangover drugs. In addition to them, tonic and analgesic substances are added to such medicines.

Thiamine is found in fermented milk products - kefir, yogurt

Save from fumes and relieve hangover in the absence of special medications, fermented milk and energy drinks will help - the latter usually contain a “loading dose” of vitamin B1. Tea can also help, but drinking special sports drink is not recommended - its composition is difficult to predict.

For heart disease

Everyone is used to thinking that for the normal functioning of the heart, only potassium and magnesium are needed, but this is not an entirely true statement.

Calcium, phosphorus, selenium, vitamins C, A, E, P, F, B1 and B6 are also important to ensure normal functioning of the heart muscle.

First, thiamine helps maintain normal nervous system, which a priori has a beneficial effect on the heart.

Secondly, it promotes stimulation of heart contractions.

Thiamine is introduced into the body during myocardial infarction, and it also has the ability to preserve vitamin C in the body.

people over thirty-five years of age;
children and adolescents;
people with vascular pathologies;
athletes;
people who have suffered severe cardiovascular diseases in the past.

HIV

Thiamine is one of the most popular vitamins prescribed to HIV-infected people. The drug is really capable of having a beneficial effect on patients with severely weakened immune systems and significantly making their life easier, and possibly prolonging it.

Vitamin B1 helps improve the body's resistance for viral infections. It is necessary for the optimal use of carbohydrates, preventing the development of feverish conditions.

For oncology

In cancer diseases, immunotherapy plays a special role.

The main vitamin for cancer patients is vitamin E, as it reduces the activity of cancer cells. Vitamins of groups A and C are also used for treatment - these are good antioxidants.

B vitamins support the heart and promote cell regeneration.

Vitamin B1 Cancer patients are prescribed for disorders of protein synthesis or protein metabolism.

For hair

B vitamins restore and nourish hair along the entire length.

The lack of the same thiamine leads to brittle and dry hair, so especially in the autumn-winter period it is recommended to pay special attention to your hair.

For facial skin

Thiamine is used to treat a number of skin conditions, especially those caused by stress.

Psoriasis, eczema, dermatitis - it is rare that a drug against them does not contain thiamine. Thiamine is also actively used in anti-aging cosmetics due to its ability to slow down the aging process.

Thiamine bromide, chloride and hydrochloride - what are these vitamins?

Thiamine bromide, thiamine chloride and thiamine hydrochloride are drugs that compensate for the deficiency of vitamin B1. All three drugs are water-soluble thiamine salts with the same effect.

Thiamine bromide

Indications for use:

polio, various encephalitis and other diseases caused by inflammation;
damage to the central nervous system, trauma, autonomic neuroses and headaches;
heart disease accompanied by tachycardia;
stomach and duodenal ulcers;
deterioration of tissue healing ability;
eating disorders;
skin rashes caused by stress;
intoxication with mercury and arsenic.

Thiamine chloride

Indications for use:

presence of liver diseases;
peripheral paralysis;
radiculitis;
myocardial dystrophy;
skin rashes caused by stress.

Thiamine hydrochloride

Indications for use:

treatment of burns;
prolonged fever;
peripheral paralysis;
chronic liver damage;
violation of coronary circulation;
various types of intoxication;
metabolic disorders;
disorders in the gastrointestinal tract.

What products contain

Thiamine is produced by plants and microorganisms; humans and animals are not able to produce it on their own. As a result, the main source of vitamin B1 for humans is plant foods.

Legumes contain a lot of thiamine

Soybeans, beans, peas and spinach contain the most thiamine, carrots and potato tubers contain slightly less. It is also found in fermented milk products - kefir, yoghurt.

Fermented milk products, being products of obvious animal origin, from a logical point of view should not contain thiamine. After all, animals do not know how to produce it, therefore, in the same kefir there is nowhere for it to come from - it cannot be in the original milk.

But it is produced by microorganisms responsible for the fermentation process. It is microorganisms that transform milk into kefir, and they also saturate kefir with thiamine.

Compatibility of vitamins B1 B6 B12

If drugs are administered by injection, they cannot be mixed in the same syringe.

B6 and B12 the first is destroyed by cobalt salts contained in the second.

With simultaneous administration of drugs B1 and B12 part of the second will oxidize. Simultaneous injection of drugs B1 and B6 practically negates the healing properties of both of them.

Not all vitamins are compatible with each other or with other medications. Taking several dietary supplements at the same time can have not only positive, but also negative effects.

However, some vitamins and microelements perfectly complement each other, enhancing their healing properties.

For example, a one-time intake of vitamins B6, K, B9 and B2 will have an extremely beneficial effect on the patient’s health.

ATTENTION

Useful video

This video talks about B vitamins, their dosage, manifestations of deficiency and compatibility:

Grand total

Vitamins and microelements are extremely important for the body. It is recommended to take a course of vitamins two to three times a year. However, first you need to determine the compatibility of the drugs.

Prescriptions of any medications, and especially their complex, must be made by a qualified physician.

Thiamine is one of the most versatile vitamins. It has a beneficial effect on the structure and growth of hair, and on the condition of facial skin. It supports the normal functioning of the gastrointestinal tract, promotes the absorption of proteins and carbohydrates, and helps the body fight viruses and intoxications (including alcohol).

Domestic veterinary drugs

THIAMIN BROMIDE. Thiamini bromide. THIAMIN CHLORIDE. Thiaminichloridum.

Properties. Thiamine bromide is a white or slightly yellowish powder. Thiamine chloride is a crystalline powder. These drugs have a weak specific odor (yeast) and are highly soluble in water; stable in acidic solutions and easily destroyed in alkaline and neutral environments.

Release form. Thiamine bromide is produced in the form of powder, tablets, dragees; 3 or 6% solutions in ampoules of 1 ml; thiamine chloride - in powders, tablets, 1; 2.5 and 5% solutions in ampoules of 1 ml.

Store in a hermetically sealed container, protected from light.

Thiamine bromide and chloride are included in various preparations, including multivitamins.

Action and application. Vitamin B1 plays an important role in the functioning of the body. It affects protein, carbohydrate and fat metabolism. Vitamin B1 takes part in metabolism, as it is part of the prosthetic group of the enzyme carboxylase, which catalyzes the dehydrogenation of pyruvic acid, improves the use of glucose, nitrogenous substances, nucleotides, ATP, stimulates the processes of transamination, carboxylation and decarboxylation, magnesium and iodine metabolism. When phosphorylated, vitamin B1 is converted into cocarboxylase, enhances and prolongs the effect of adrenaline, and is involved in the utilization of hormones (corticosteroids and estrogens). Normalizes the activity of the central and peripheral nervous system (prevents the development of polyneuritis), the reticuloendothelial system, improves digestion, stimulates growth and development. With a lack of vitamin B1 in the body of animals, B1-avitaminosis and B1-hypovitaminosis develop, which leads to the accumulation of pyruvic and lactic acids, cessation of acetylcholine synthesis, and incomplete oxidation of glucose. In this case, the function of the central and peripheral nervous and cardiovascular systems is disrupted. Vitamin B1 has a positive effect on the secretory-motor function of the gastrointestinal tract and some endocrine glands.

Thiamine prevents and cures a severe form of vitamin deficiency in humans - Beriberi - and polyneuritis in animals.

Prescribed for the treatment and prevention of hypo- and avitaminosis B 1 in diseases of the central and peripheral nervous system, polyneuritis of various origins, to increase the secretion and digestive activity of gastric juice, with atony of the stomach and intestines, liver diseases, spasms of peripheral vessels, dermatoses of neurogenic origin, with neurotoxic dyspepsia of piglets, treatment with antibiotics (tetracycline, chloramphenicol, neomycin sulfate), for various infectious diseases, to improve the growth and development of animals and poultry. Vitamin B1 is administered orally and parenterally. It is usually well tolerated by animals. However, subcutaneous injections can sometimes cause various allergic reactions.

From the body of animals, thiamine is usually excreted in the urine, and in birds - in the egg. Chickens hatched from the eggs of chickens whose diet did not receive enough vitamin B die from polyneuritis.

Doses under the skin or intramuscularly thiamine bromide (or chloride): calves 50-100 mg, piglets 10-20 mg, chickens 1-2 mg. Inside: piglets 25-40 mg; chickens 3-4 mg; minks 5-10 mg.

Instead of vitamin B preparations, you can use food rich in it, especially greens, cereal bran, yeast, grass flour, sprouted grains, sunflower cake, milk, cottage cheese, skim milk, meat and fish meal, etc.

Thiamine: instructions for use and reviews

Latin name: Thiamine

ATX code: A11DA01

Active ingredient: thiamine*

Manufacturer: Dalkhimfarm (Russia), Ozon LLC (Russia), Microgen NPO FSUE (NPO Virion) (Russia), Novosibkhimpharm (Russia)

Updating the description and photo: 12.08.2019

Thiamine is vitamin B1.

Release form and composition

Dosage form - solution for intramuscular (IM) administration: liquid with a transparent structure, slightly colored or colorless, with a characteristic faint odor (in ampoules: 1 ml or 2 ml - in a cardboard pack of 10 pcs.; in a contour cell or plastic packaging 5 or 10 pcs., in a cardboard pack 1 or 2 packs; 1 ml - in a cardboard tray 5 pcs., in a cardboard pack 1 or 2 trays).

1 ml of solution contains:

active ingredient: thiamine hydrochloride – 25 mg or 50 mg;
excipients: unithiol (sodium dimercaptopropanesulfonate monohydrate), water for injection.

Pharmacological properties

Pharmacodynamics

Thiamine - vitamin B1 - is a water-soluble vitamin. It is a coenzyme of enzymes responsible for the regulation of protein and carbohydrate metabolism. Thiamine is characterized by a moderate ganglion-blocking effect and ensures the conduction of nerve impulses at synapses. It also has an antioxidant effect and increases the protection of cell membranes from the toxic effects of peroxidation products.

Pharmacokinetics

When taken orally on an empty stomach, Thiamine is almost completely absorbed from the gastrointestinal tract. Before absorption, it is released from its bound state thanks to digestive enzymes. 15 minutes after administration, vitamin B1 is determined in the blood plasma, and after 30 minutes - in other tissues. In the blood, its concentration remains relatively low, and predominantly free thiamine is found in plasma, and its phosphorus esters are found in leukocytes and erythrocytes.

The substance is distributed throughout all tissues: more than 50% of the administered amount is contained in striated muscles, approximately 40% in internal organs. There is a relative predominance of thiamine concentrations in the liver, skeletal muscles, nervous tissue and myocardium, which is likely due to increased consumption of the compound by these structures.

Vitamin B1 is metabolized in the liver through phosphorylation, forming thiamine diphosphate (cocarboxylase), which has coenzyme activity and plays an important role in the participation of thiamine in fat and carbohydrate metabolism. The drug is excreted through the intestines and kidneys.

Indications for use

According to the instructions, Thiamine is indicated for vitamin B1 deficiency and hypovitaminosis, as well as as part of complex therapy for the following diseases:

radiculitis, neuritis, neuralgia;
paralysis, peripheral paresis;
decreased secretory and motor functions of the stomach;
peptic ulcer of the stomach and duodenum;
atonic constipation;
intestinal atony;
anorexia;
violation of coronary circulation;
myocardial dystrophy;
diabetes mellitus;
dermatoses (psoriasis, eczema, lichen planus, neurodermatitis), accompanied by neurotrophic changes and metabolic disorders.

Contraindications

Individual intolerance to the drug.

It should be used with caution in Wernicke encephalopathy, in women during the premenopausal period and after menopause.

Instructions for use of Thiamine: method and dosage

Thiamine solution in ampoules is intended for deep intramuscular administration.

Therapy should be started with low doses (up to 0.5 ml of a 5% solution), then if well tolerated, the dose is increased.

adults: 25–50 mg;
children: 12.5 mg (0.5 ml of 2.5% solution).

Frequency of use – 1 time per day, duration of treatment – 10–30 days.

Side effects

With the use of vitamin B 1, increased sweating, the development of tachycardia, allergic reactions in the form of skin itching, urticaria, Quincke's edema, and anaphylactic shock are possible; sometimes – a feeling of pain at the injection site.

Overdose

Cases of overdose of Thiamine solution when administered in high doses have not been described. If necessary, symptomatic treatment is prescribed.

Special instructions

When using high doses of the drug, it is possible to distort the results of the spectrophotometric method for determining theophylline in blood serum, laboratory tests of urine using the Ehrlich reagent for urobilinogen.

An anaphylactic reaction often develops in patients after intravenous administration of high doses.

Dextrose for Wernicke's encephalopathy should be taken before the administration of Thiamine.

Use during pregnancy and lactation

The use of the drug during pregnancy and breastfeeding is acceptable.

Drug interactions

With the simultaneous parenteral use of Thiamine with pyridoxine (vitamin B 6), the process of converting thiamine hydrochloride into a biologically active form is hampered; with cyanocobalamin (vitamin B 12), the risk of an allergic effect of the drug increases, so these combinations are not recommended.

The drug should not be mixed in the same syringe with benzylpenicillin or streptomycin (this causes the destruction of antibiotics), solutions containing sulfites (thiamine hydrochloride completely disintegrates), nicotinic acid (due to the destruction of thiamine).

When combined with phentolamine, suxamethonium iodide, propranolol, hypnotics, sympatholytics (reserpine), their pharmacological activity decreases.

Vitamin B 1 is unstable in neutral and alkaline solutions.